Pub Date : 2013-10-03DOI: 10.4172/2090-5025.1000067
E. Kramer, M. Zilm, M. Wei
Hydroxyapatite (HA) is a widely studied biomaterial for bone grafting and tissue engineering applications. The crystal structure of HA lends itself to a wide variety of substitutions, which allows for tailoring of material properties. Iron is of interest in ion substitution in HA due to its magnetic properties. The synthesis and characterization of iron-substituted hydroxyapatite (FeHA) have been widely studied, but there is a lack of studies on the sintering behaviors of FeHA materials compared to pure HA. Studying the sintering behavior of a substituted apatite provides information regarding how the substitution affects material characteristics such as stability and bulk mechanical properties, thereby providing insight into which applications are appropriate for the substituted material. In this study both pure HA and FeHA were synthesized, pressed into pellets, and then sintered at temperatures ranging from 900- 1300°C and 600-1100°C, respectively. The study thoroughly examined the comparative sintering behaviors of the two materials using density measurements, mechanical testing, X-ray diffraction, and electron microscopy. It was found that FeHA is considerably less thermally stable than pure HA, with decomposition beginning around 1200°C for pure HA samples, while at 700°C for the FeHA. The FeHA also had a much lower mechanical strength than that of the pure HA. An in vitro cell culture study was conducted by immersing FeHA powder in cell culture media, with HA powder at equivalent doses as a control, verified that FeHA is a biocompatible material. Although the FeHA would be unsuitable for bulk applications, it is a potential material for a variety of biomedical applications including drug delivery, cancer hyperthermia, and bone tissue engineering composites.
{"title":"A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite","authors":"E. Kramer, M. Zilm, M. Wei","doi":"10.4172/2090-5025.1000067","DOIUrl":"https://doi.org/10.4172/2090-5025.1000067","url":null,"abstract":"Hydroxyapatite (HA) is a widely studied biomaterial for bone grafting and tissue engineering applications. The crystal structure of HA lends itself to a wide variety of substitutions, which allows for tailoring of material properties. Iron is of interest in ion substitution in HA due to its magnetic properties. The synthesis and characterization of iron-substituted hydroxyapatite (FeHA) have been widely studied, but there is a lack of studies on the sintering behaviors of FeHA materials compared to pure HA. Studying the sintering behavior of a substituted apatite provides information regarding how the substitution affects material characteristics such as stability and bulk mechanical properties, thereby providing insight into which applications are appropriate for the substituted material. In this study both pure HA and FeHA were synthesized, pressed into pellets, and then sintered at temperatures ranging from 900- 1300°C and 600-1100°C, respectively. The study thoroughly examined the comparative sintering behaviors of the two materials using density measurements, mechanical testing, X-ray diffraction, and electron microscopy. It was found that FeHA is considerably less thermally stable than pure HA, with decomposition beginning around 1200°C for pure HA samples, while at 700°C for the FeHA. The FeHA also had a much lower mechanical strength than that of the pure HA. An in vitro cell culture study was conducted by immersing FeHA powder in cell culture media, with HA powder at equivalent doses as a control, verified that FeHA is a biocompatible material. Although the FeHA would be unsuitable for bulk applications, it is a potential material for a variety of biomedical applications including drug delivery, cancer hyperthermia, and bone tissue engineering composites.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129315719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-09-10DOI: 10.4172/2090-5025.S1-009
M. Mabrouk, A. Mostafa, H. Oudadesse, A. Mahmoud, A. Gaafar, MI El-Gohary
Composite scaffolds of Polyvinyl Alcohol (PVA) and/or quaternary bioactive glass (46S6 system) containing 5, 10 and 20 wt % ciprofloxacin were prepared by lyophilisation technique. The porosity of the prepared scaffolds was measured by liquid displacement, Hg-porosimeter and SEM. The structure and the nature of chemical bonds between atoms were examined by XRD and FTIR. They confirmed the incorporation of ciprofloxacin into the scaffolds. Biodegradation rate and drug release behaviour were conducted in Phosphate Buffer Saline (PBS) at pH 7.4. A porous scaffold has been obtained with porosity up to 85%. By increasing the glass contents and drug concentration in the prepared scaffold the porosity and the degradation rate decrease however, the compressive strength was enhanced. A sustained drug release pattern was observed from the optimized scaffold with a quasi-Fickian diffusion mechanism and it was able to deliver the drug in a prolonged release pattern which offers a distinguish treatment for osteomylitis as well as local antibacterial effect.
{"title":"Fabrication, Characterization and Drug Release of Ciprofloxacin Loaded Porous Polyvinyl Alcohol/Bioactive Glass Scaffold for Controlled DrugDelivery","authors":"M. Mabrouk, A. Mostafa, H. Oudadesse, A. Mahmoud, A. Gaafar, MI El-Gohary","doi":"10.4172/2090-5025.S1-009","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-009","url":null,"abstract":"Composite scaffolds of Polyvinyl Alcohol (PVA) and/or quaternary bioactive glass (46S6 system) containing 5, 10 and 20 wt % ciprofloxacin were prepared by lyophilisation technique. The porosity of the prepared scaffolds was measured by liquid displacement, Hg-porosimeter and SEM. The structure and the nature of chemical bonds between atoms were examined by XRD and FTIR. They confirmed the incorporation of ciprofloxacin into the scaffolds. Biodegradation rate and drug release behaviour were conducted in Phosphate Buffer Saline (PBS) at pH 7.4. A porous scaffold has been obtained with porosity up to 85%. By increasing the glass contents and drug concentration in the prepared scaffold the porosity and the degradation rate decrease however, the compressive strength was enhanced. A sustained drug release pattern was observed from the optimized scaffold with a quasi-Fickian diffusion mechanism and it was able to deliver the drug in a prolonged release pattern which offers a distinguish treatment for osteomylitis as well as local antibacterial effect.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130079079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-09-09DOI: 10.4172/2090-5025.S1-011
T. Toyama, S. Kameda, N. Nishimiya
The composition of Hydroxyapatite (HAp) is expressed by the formula Ca10(PO4)6(OH)2. Many reports have been published on the synthesis of HAp in which Ca ions are substituted by various cations (e.g., Sr, Ba). On the other hand, studies on the synthesis of sulfate-ion-substituted hydroxyapatite (SAp) have rarely been conducted. The present study investigated the conditions for the synthesis of SAp from amorphous calcium phosphate (ACP, Ca3(PO4)2• nH2O) as the starting material, which can readily incorporate various ions into its structure. Sodium sulfate (Na2SO4) was added to ACP, and then, the mixture was hydrothermally processed at 220°C for 3 h. SAp obtained under these conditions had a Ca-deficient-type HAp structure. The SO4/PO4 molar ratio in SAp increased with increasing amounts of added Na2SO4, reaching a maximum value of 0.5, meaning that 1/3 of the PO4 3– ions contained in HAp were substituted by SO4 2– ions.
{"title":"Synthesis of Sulfate-ion-substituted Hydroxyapatite from Amorphous Calcium Phosphate","authors":"T. Toyama, S. Kameda, N. Nishimiya","doi":"10.4172/2090-5025.S1-011","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-011","url":null,"abstract":"The composition of Hydroxyapatite (HAp) is expressed by the formula Ca10(PO4)6(OH)2. Many reports have been published on the synthesis of HAp in which Ca ions are substituted by various cations (e.g., Sr, Ba). On the other hand, studies on the synthesis of sulfate-ion-substituted hydroxyapatite (SAp) have rarely been conducted. The present study investigated the conditions for the synthesis of SAp from amorphous calcium phosphate (ACP, Ca3(PO4)2• nH2O) as the starting material, which can readily incorporate various ions into its structure. Sodium sulfate (Na2SO4) was added to ACP, and then, the mixture was hydrothermally processed at 220°C for 3 h. SAp obtained under these conditions had a Ca-deficient-type HAp structure. The SO4/PO4 molar ratio in SAp increased with increasing amounts of added Na2SO4, reaching a maximum value of 0.5, meaning that 1/3 of the PO4 3– ions contained in HAp were substituted by SO4 2– ions.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114574600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-09-06DOI: 10.4172/2090-5025.s1-010
Tomohiro Uchino, Kana Ichikawa, Rina Mashima, K. Tamura
Some titanium containing apatite (TMA) ceramics prepared by wet synthesis was superior to Hydroxyapatite (HAp) ceramics of mechanical property and cutting performance. In this study, we investigated chemical reaction of TMA in a body environment. Each TMA or commercial Hydroxyapatite powder (HAp) was formed to circular pellets by uniaxial pressing. The specimens were heated in muffle furnace by conventional sintering process. Some TMA specimens were dispensed by alkali and heat treatment. After the treatments, the specimens were soaked in simulated body fluid (SBF: Kokubo’s solution) at pH 7.25 at 37.0°C up to 7 days. Before and after soaking in SBF, the surfaces of the samples were characterized by XRD, SEM, and ICP. After soaking in SBF for 7days, some particles were precipitated on the surface of HAp ceramics and TMA ceramics with alkali and heat treatment. Ti-containing in the crystal structure of HAp affected apatite formation in the body environment.
{"title":"Apatite Formation on Titanium Containing Apatite","authors":"Tomohiro Uchino, Kana Ichikawa, Rina Mashima, K. Tamura","doi":"10.4172/2090-5025.s1-010","DOIUrl":"https://doi.org/10.4172/2090-5025.s1-010","url":null,"abstract":"Some titanium containing apatite (TMA) ceramics prepared by wet synthesis was superior to Hydroxyapatite (HAp) ceramics of mechanical property and cutting performance. In this study, we investigated chemical reaction of TMA in a body environment. Each TMA or commercial Hydroxyapatite powder (HAp) was formed to circular pellets by uniaxial pressing. The specimens were heated in muffle furnace by conventional sintering process. Some TMA specimens were dispensed by alkali and heat treatment. After the treatments, the specimens were soaked in simulated body fluid (SBF: Kokubo’s solution) at pH 7.25 at 37.0°C up to 7 days. Before and after soaking in SBF, the surfaces of the samples were characterized by XRD, SEM, and ICP. After soaking in SBF for 7days, some particles were precipitated on the surface of HAp ceramics and TMA ceramics with alkali and heat treatment. Ti-containing in the crystal structure of HAp affected apatite formation in the body environment.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130185747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-27DOI: 10.4172/2090-5025.S1-012
S. Stevanovic, P. Chavanne, O. Braissant, U. Pieles, P. Gruner, R. Schumacher
Tailor made bioceramic scaffolds in combination with the corresponding surface chemistry and biology is of great importance for a successful implantation and rapid osseo-integration. The present study investigates the fabrication of Hydroxyapatite (HA) scaffolds with defined macro porosity by means of powder based 3D-printing. In order to mime natural bone with its elastic collagen structure, the 3D-printed ceramic structures were post-treated by polymeric infiltration. Compressive Strength analysis (CS) confirmed the positive impact of an elastomeric phase on mechanical properties. 3D-printed HA scaffolds in combination with polymer result in biodegradable scaffolds with promising mechanical properties for potential use in regenerative medicine.
{"title":"Improvement of Mechanical Properties of 3d Printed Hydroxyapatite Scaffolds by Polymeric Infiltration","authors":"S. Stevanovic, P. Chavanne, O. Braissant, U. Pieles, P. Gruner, R. Schumacher","doi":"10.4172/2090-5025.S1-012","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-012","url":null,"abstract":"Tailor made bioceramic scaffolds in combination with the corresponding surface chemistry and biology is of great importance for a successful implantation and rapid osseo-integration. The present study investigates the fabrication of Hydroxyapatite (HA) scaffolds with defined macro porosity by means of powder based 3D-printing. In order to mime natural bone with its elastic collagen structure, the 3D-printed ceramic structures were post-treated by polymeric infiltration. Compressive Strength analysis (CS) confirmed the positive impact of an elastomeric phase on mechanical properties. 3D-printed HA scaffolds in combination with polymer result in biodegradable scaffolds with promising mechanical properties for potential use in regenerative medicine.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127974194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-27DOI: 10.4172/2090-5025.S1-013
E. Wers, L. Bunetel, H. Oudadesse, B. Lefeuvre, A. Lucas-Girot, A. Mostafa, P. Pellen
Bioactive glasses, doped with traces of copper (Cu) and zinc (Zn) were synthesized by fusion method. Cu and Zn present interesting functions for the biological metabolism through their antibacterial, anti-inflammatory and antifungal properties. Several physical methods were employed to characterize the bioactive glasses before and after immersion in a Simulated Body Fluid (SBF). The “in vitro” experiments showed that after soaking in SBF, the behavior of bioactive doped glasses are different compared to pure glass 46S6. Obtained results show that glass matrix undergoes some changes after 15 days of immersion. The non toxic character of doped glasses was confirmed after 24 hours of incubation. The kinetic of release of Cu and Zn was carried out. It highlights that Cu is more released than Zn. By SEM, the morphology of hydroxyapatite obtained with Zn-doped glass show a better crystallization compared to Cu-doped glass.
{"title":"Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive Glasses","authors":"E. Wers, L. Bunetel, H. Oudadesse, B. Lefeuvre, A. Lucas-Girot, A. Mostafa, P. Pellen","doi":"10.4172/2090-5025.S1-013","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-013","url":null,"abstract":"Bioactive glasses, doped with traces of copper (Cu) and zinc (Zn) were synthesized by fusion method. Cu and Zn present interesting functions for the biological metabolism through their antibacterial, anti-inflammatory and antifungal properties. Several physical methods were employed to characterize the bioactive glasses before and after immersion in a Simulated Body Fluid (SBF). The “in vitro” experiments showed that after soaking in SBF, the behavior of bioactive doped glasses are different compared to pure glass 46S6. Obtained results show that glass matrix undergoes some changes after 15 days of immersion. The non toxic character of doped glasses was confirmed after 24 hours of incubation. The kinetic of release of Cu and Zn was carried out. It highlights that Cu is more released than Zn. By SEM, the morphology of hydroxyapatite obtained with Zn-doped glass show a better crystallization compared to Cu-doped glass.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129049632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-23DOI: 10.4172/2090-5025.S1-007
N. Kato, E. Yamamoto, Arata Isai, H. Nishikawa, M. Kusunoki, K. Yoshikawa, S. Hontsu
Novel dentin tubule sealing technique using ultrathin Amorphous Calcium Phosphate (ACP) freestanding sheet was developed. The sheets were prepared by pulsed laser deposition technique and separated from quarts substrate by dissolving photoresist as sacrifice layer. Sheets were pasted on dentin of extracted human teeth by using calcium phosphate aqueous solution. The sheets kept wetted by artificial saliva for a few days. After drying specimens, the bonding strength between the sheets and dentin were evaluated by quasi-tensile tests. The bonding strengths between the film and dentin were enough to seal dentin tubules. After tensile test, the specimens were embedded in epoxy resin and polished for investigation of bonding boundary nature. The presence of a few microns thick bonding layer between the film and dentin was shown clearly by cross-sectional electron microgram. These results suggest that the dentin tubules may be sealed by calcium phosphate sheet without organic materials.
{"title":"Ultrathin Amorphous Calcium Phosphate Freestanding Sheet for Dentin Tubule Sealing","authors":"N. Kato, E. Yamamoto, Arata Isai, H. Nishikawa, M. Kusunoki, K. Yoshikawa, S. Hontsu","doi":"10.4172/2090-5025.S1-007","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-007","url":null,"abstract":"Novel dentin tubule sealing technique using ultrathin Amorphous Calcium Phosphate (ACP) freestanding sheet was developed. The sheets were prepared by pulsed laser deposition technique and separated from quarts substrate by dissolving photoresist as sacrifice layer. Sheets were pasted on dentin of extracted human teeth by using calcium phosphate aqueous solution. The sheets kept wetted by artificial saliva for a few days. After drying specimens, the bonding strength between the sheets and dentin were evaluated by quasi-tensile tests. The bonding strengths between the film and dentin were enough to seal dentin tubules. After tensile test, the specimens were embedded in epoxy resin and polished for investigation of bonding boundary nature. The presence of a few microns thick bonding layer between the film and dentin was shown clearly by cross-sectional electron microgram. These results suggest that the dentin tubules may be sealed by calcium phosphate sheet without organic materials.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125847375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-23DOI: 10.4172/2090-5025.S1-005
F. Imrie, J. Skakle, I. Gibson
The pro-angiogenic potential of copper ions could increase the viability of bone forming cells within a bone substitute scaffold, and so hasten healing, by stimulating infiltration of blood vessels into the scaffold. Copper-doped hydroxyapatite with x = 0, 0.5, 0.75 and 1 in the nominal formula Ca10(PO4)6CuxOyHz was prepared by solid state synthesis. Lattice parameters increased as x was increased, consistent with formation of Cu-O species on hydroxyl sites. In FT-IR spectra, the OH stretch (3572 cm-1) and the OH libration (631 cm-1) decreased in intensity as x was increased, and a band at 771-778 cm-1 was assignable to a Cu-O stretch, characteristic of Cu+ bands between 3140 and 3450 cm-1 related to copper-disturbed OH stretching vibrations. In UV visible spectra, bands between 400 and 800 nm were assignable to d-d transitions of Cu2+. Therefore we propose that Cu is present in these materials both as Cu+ and Cu2+.
{"title":"Preparation of Copper-Doped Hydroxyapatite with Varying x in the Composition Ca10(PO4)6CuxOyHz","authors":"F. Imrie, J. Skakle, I. Gibson","doi":"10.4172/2090-5025.S1-005","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-005","url":null,"abstract":"The pro-angiogenic potential of copper ions could increase the viability of bone forming cells within a bone substitute scaffold, and so hasten healing, by stimulating infiltration of blood vessels into the scaffold. Copper-doped hydroxyapatite with x = 0, 0.5, 0.75 and 1 in the nominal formula Ca10(PO4)6CuxOyHz was prepared by solid state synthesis. Lattice parameters increased as x was increased, consistent with formation of Cu-O species on hydroxyl sites. In FT-IR spectra, the OH stretch (3572 cm-1) and the OH libration (631 cm-1) decreased in intensity as x was increased, and a band at 771-778 cm-1 was assignable to a Cu-O stretch, characteristic of Cu+ bands between 3140 and 3450 cm-1 related to copper-disturbed OH stretching vibrations. In UV visible spectra, bands between 400 and 800 nm were assignable to d-d transitions of Cu2+. Therefore we propose that Cu is present in these materials both as Cu+ and Cu2+.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121870236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-23DOI: 10.4172/2090-5025.S1-008
Tsutomu Nishigaki, H. Nishikawa, M. Kusunoki, S. Hontsu
In order to measure the piezoelectric properties of the Hydroxyapatite (HAp) films, we have fabricated Cu/HAp/Ti or Cu/HAp/Pt structure. At first, a 1.5 m thick HAp was deposited on a Ti or Pt substrate using the KrF Pulsed Laser Deposition (PLD) method. After the HAp deposition, the HAp film was crystallized by post-annealing in nitrogen gas atmosphere and cooled slowly in an electric furnace. Then, a Cu top electrode sheet was attached on HAp film. Finally, one end of the Cu/HAp/Ti or Cu/HAp/Pt structure was clamped to compose a vibrating cantilever beam. Piezoelectric coefficients were estimated by output voltage responses of HAp films measured by a operational amplifier circuit when the Cu/HAp/Ti or Cu/HAp/Pt beam was excited by a mini-shaker at the first natural frequency of the beam. The results showed the piezoelectricity of the artificially synthesized HAp films.
{"title":"Measurement of Piezoelectric Properties of Pulsed Laser Deposited Hydroxyapatite Thin Films on Platinum or Titanium Substrate","authors":"Tsutomu Nishigaki, H. Nishikawa, M. Kusunoki, S. Hontsu","doi":"10.4172/2090-5025.S1-008","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-008","url":null,"abstract":"In order to measure the piezoelectric properties of the Hydroxyapatite (HAp) films, we have fabricated Cu/HAp/Ti or Cu/HAp/Pt structure. At first, a 1.5 m thick HAp was deposited on a Ti or Pt substrate using the KrF Pulsed Laser Deposition (PLD) method. After the HAp deposition, the HAp film was crystallized by post-annealing in nitrogen gas atmosphere and cooled slowly in an electric furnace. Then, a Cu top electrode sheet was attached on HAp film. Finally, one end of the Cu/HAp/Ti or Cu/HAp/Pt structure was clamped to compose a vibrating cantilever beam. Piezoelectric coefficients were estimated by output voltage responses of HAp films measured by a operational amplifier circuit when the Cu/HAp/Ti or Cu/HAp/Pt beam was excited by a mini-shaker at the first natural frequency of the beam. The results showed the piezoelectricity of the artificially synthesized HAp films.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132941989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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