Pub Date : 2014-07-04DOI: 10.4172/2090-5025.1000078
Jonathan Y. Chen, Liangfeng Sun, J. VincentEdwards
The present work reports an initial engineering approach for fabricating lysozyme-bound regenerated cellulose fiber and film. Glycine-esterified cotton was dissolved in an ionic liquid solvent 1–Butyl–3–methylimidazolium Chloride (BMIMCl) in which lysozyme was activated and covalently attached to cotton cellulose through an enzymatic conjugation between its carboxyl groups and glycine cellulose’s amino groups. The resulting solution was extruded for fiber/film formation in a water bath. After performing a bicinchoninic acid (BCA) protein assay, quantity of attached lysozyme to cellulose fiber/film was evaluated. The study exhibited that a synthesis of lysozyme conjugation on cellulose in BMIMCl could be completed in a control manor, resulting in a cellulose solution suitable for fiber/film production. It was also found that lysozyme could be successfully immobilized onto the cellulose fiber and film regenerated from solution spinning with a reasonable amount ranging from 197.6 to 343.7 μg/mL.mg.
{"title":"Regenerated Cellulose Fiber and Film Immobilized with Lysozyme","authors":"Jonathan Y. Chen, Liangfeng Sun, J. VincentEdwards","doi":"10.4172/2090-5025.1000078","DOIUrl":"https://doi.org/10.4172/2090-5025.1000078","url":null,"abstract":"The present work reports an initial engineering approach for fabricating lysozyme-bound regenerated cellulose fiber and film. Glycine-esterified cotton was dissolved in an ionic liquid solvent 1–Butyl–3–methylimidazolium Chloride (BMIMCl) in which lysozyme was activated and covalently attached to cotton cellulose through an enzymatic conjugation between its carboxyl groups and glycine cellulose’s amino groups. The resulting solution was extruded for fiber/film formation in a water bath. After performing a bicinchoninic acid (BCA) protein assay, quantity of attached lysozyme to cellulose fiber/film was evaluated. The study exhibited that a synthesis of lysozyme conjugation on cellulose in BMIMCl could be completed in a control manor, resulting in a cellulose solution suitable for fiber/film production. It was also found that lysozyme could be successfully immobilized onto the cellulose fiber and film regenerated from solution spinning with a reasonable amount ranging from 197.6 to 343.7 μg/mL.mg.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134118798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-25DOI: 10.4172/2090-5025.1000E106
M. Mozafari
Bioceramics have revolutionized the field of medicine by giving us the hope of generating engineered human tissues. During the past years, there have been great advances in bioceramics, glasses and glassceramics, and recently emphasis has shifted towards the use of this class of biomaterials especially for bone and dental tissue engineering. On this front, with the advent of advanced bioceramics, it has been speculated that the search for ideal combination of different methods and materials could result in significant advances in different areas of medicine over future years. Undoubtedly, this class of biomaterials needs further advancement and a lot of critical questions have yet to be answered. This note shortly reviews the groundbreaking work that has been performed in the field of bioceramics.
{"title":"Bioceramics in the Realm of History","authors":"M. Mozafari","doi":"10.4172/2090-5025.1000E106","DOIUrl":"https://doi.org/10.4172/2090-5025.1000E106","url":null,"abstract":"Bioceramics have revolutionized the field of medicine by giving us the hope of generating engineered human tissues. During the past years, there have been great advances in bioceramics, glasses and glassceramics, and recently emphasis has shifted towards the use of this class of biomaterials especially for bone and dental tissue engineering. On this front, with the advent of advanced bioceramics, it has been speculated that the search for ideal combination of different methods and materials could result in significant advances in different areas of medicine over future years. Undoubtedly, this class of biomaterials needs further advancement and a lot of critical questions have yet to be answered. This note shortly reviews the groundbreaking work that has been performed in the field of bioceramics.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115485384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-06-10DOI: 10.4172/2090-5025.1000E105
Yiquan Wu
Electrohydrodynamic atomization phenomena has increasingly attracted the attention of researchers who are interested in pursuing this promising technique to prepare microor nanometer architectures such as fibers and encapsulated particles with a controllable microstructure. There are two main techniques in the electrohydrodynamic atomization processing: electrospraying and electrospinning. Electrospraying can create particles by applying a uniform electrohydrodynamic force to break up liquids into fine jets, and is an emerging method for the rapid and high throughput production of nano-meso scale particles of controlled morphology for controlled release during drug delivery. The morphology and size of electrosprayed polymer nanoparticles is strongly influenced by a host of variables that include processing parameters and the material properties of the solution such as polymer composition, molecular weight, the solvent used for polymer dissolution, and the presence and concentration of other cosolutes. In a typical electrospinning process, the precursor solution is held at the end of the nozzle in the form of a droplet by its surface tension. As is the case with electrospraying, a voltage applied to the nozzle results in the formation of a Taylor cone, from which a jet of the precursor solution will erupt. Although the jet in a Taylor-cone mode is stable near to the tip of the nozzle, it undergoes a fluid instability stage that leads to accelerated solidification of the jet and a thinning of the fibers as the jet approaches the collector [1-4] (Figures 1 and 2).
{"title":"Electrohydrodynamic Atomization Processing Biologically Nanostructured Materials","authors":"Yiquan Wu","doi":"10.4172/2090-5025.1000E105","DOIUrl":"https://doi.org/10.4172/2090-5025.1000E105","url":null,"abstract":"Electrohydrodynamic atomization phenomena has increasingly attracted the attention of researchers who are interested in pursuing this promising technique to prepare microor nanometer architectures such as fibers and encapsulated particles with a controllable microstructure. There are two main techniques in the electrohydrodynamic atomization processing: electrospraying and electrospinning. Electrospraying can create particles by applying a uniform electrohydrodynamic force to break up liquids into fine jets, and is an emerging method for the rapid and high throughput production of nano-meso scale particles of controlled morphology for controlled release during drug delivery. The morphology and size of electrosprayed polymer nanoparticles is strongly influenced by a host of variables that include processing parameters and the material properties of the solution such as polymer composition, molecular weight, the solvent used for polymer dissolution, and the presence and concentration of other cosolutes. In a typical electrospinning process, the precursor solution is held at the end of the nozzle in the form of a droplet by its surface tension. As is the case with electrospraying, a voltage applied to the nozzle results in the formation of a Taylor cone, from which a jet of the precursor solution will erupt. Although the jet in a Taylor-cone mode is stable near to the tip of the nozzle, it undergoes a fluid instability stage that leads to accelerated solidification of the jet and a thinning of the fibers as the jet approaches the collector [1-4] (Figures 1 and 2).","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124716777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-09DOI: 10.4172/2090-5025.1000E104
O. Gunduz, Faik Nuzhet Oktarc
Oguzhan Gunduz1,2* and Faik Nuzhet Oktarc2,3 1Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Goztepe Campus, Istanbul, 34722, Turkey 2Centre for Nanotechnology & Biomaterials Applied and Research At Marmara University, Goztepe Campus, Kadikoy, Istanbul, 34722, Turkey 3Department of Bioengineering, Faculty of Engineering, Marmara University, Goztepe Campus, Istanbul, 34722, Turkey *Corresponding author: Oguzhan Gunduz, Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Goztepe Campus, Istanbul, 34722, Turkey, Tel: 0 216 347 76 81 E-mail: oguzhan@marmara.edu.tr
{"title":"Preparation of Scaffolds and New Biomaterials for Health Care Industries","authors":"O. Gunduz, Faik Nuzhet Oktarc","doi":"10.4172/2090-5025.1000E104","DOIUrl":"https://doi.org/10.4172/2090-5025.1000E104","url":null,"abstract":"Oguzhan Gunduz1,2* and Faik Nuzhet Oktarc2,3 1Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Goztepe Campus, Istanbul, 34722, Turkey 2Centre for Nanotechnology & Biomaterials Applied and Research At Marmara University, Goztepe Campus, Kadikoy, Istanbul, 34722, Turkey 3Department of Bioengineering, Faculty of Engineering, Marmara University, Goztepe Campus, Istanbul, 34722, Turkey *Corresponding author: Oguzhan Gunduz, Department of Metallurgy and Material Engineering, Faculty of Technology, Marmara University, Goztepe Campus, Istanbul, 34722, Turkey, Tel: 0 216 347 76 81 E-mail: oguzhan@marmara.edu.tr","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124857902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-03-07DOI: 10.4172/2090-5025.1000E103
K. Ishikawa
Ceramics is the only biomaterials that up-regulate cells’ differentiation process. For example, apatite ceramics up-regulate differentiation of bone-related and connective tissue related cells. As a result, apatite and its related bioceramics hashave been used in clinics, especially for the regeneration and reconstruction of bone tissue defects. Despite the long history of apatite ceramics use, detailed mechanism of the up-regulation of osteoblasts by apatite ceramics has not been clarified up to date. This unfortunate current situation may arise, at least in part, to the usefulness of apatite ceramics for clinical use. Clinical application studies have been focused more attention rather than science of apatite. Although progress of apatite science is strongly awaited, application study of apatite seems to be accelerated due to the need of apatite ceramics in regenerative medicine.
{"title":"Ceramics that Up-regulate Cells Differentiation Process","authors":"K. Ishikawa","doi":"10.4172/2090-5025.1000E103","DOIUrl":"https://doi.org/10.4172/2090-5025.1000E103","url":null,"abstract":"Ceramics is the only biomaterials that up-regulate cells’ differentiation process. For example, apatite ceramics up-regulate differentiation of bone-related and connective tissue related cells. As a result, apatite and its related bioceramics hashave been used in clinics, especially for the regeneration and reconstruction of bone tissue defects. Despite the long history of apatite ceramics use, detailed mechanism of the up-regulation of osteoblasts by apatite ceramics has not been clarified up to date. This unfortunate current situation may arise, at least in part, to the usefulness of apatite ceramics for clinical use. Clinical application studies have been focused more attention rather than science of apatite. Although progress of apatite science is strongly awaited, application study of apatite seems to be accelerated due to the need of apatite ceramics in regenerative medicine.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125780496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-02-05DOI: 10.4172/2090-5025.1000074
Johanna Unosson, H. Engqvist
Compared to cortical bone and polymeric bone cements, the mechanical properties of calcium phosphate cements are generally poor. This has resulted in them being used in non-load bearing clinical applications. The aim of this study was to investigate the possibility of producing a brushite cement with mechanical properties closer to those of cortical bone (i.e., >100 MPa in compression), i.e. with a potential to be used in load bearing applications. With a compressive strength of 74.4 (± 10.7) MPa, maximum at 91.8 MPa, the cement presented herein is comparable with the non degradable polymeric counterparts and the strongest hydroxyapatite cements, and is close in strength of cortical bone. Furthermore, it has a high injectability (>90%) and a setting time of approximately 17 minutes. A cement comprising these properties has great potential of changing the future clinical indications for calcium phosphate cements, and could potentially reduce the use of non-degradable polymeric cements.
{"title":"Development of a Resorbable Calcium Phosphate Cement with Load Bearing Capacity","authors":"Johanna Unosson, H. Engqvist","doi":"10.4172/2090-5025.1000074","DOIUrl":"https://doi.org/10.4172/2090-5025.1000074","url":null,"abstract":"Compared to cortical bone and polymeric bone cements, the mechanical properties of calcium phosphate cements are generally poor. This has resulted in them being used in non-load bearing clinical applications. The aim of this study was to investigate the possibility of producing a brushite cement with mechanical properties closer to those of cortical bone (i.e., >100 MPa in compression), i.e. with a potential to be used in load bearing applications. With a compressive strength of 74.4 (± 10.7) MPa, maximum at 91.8 MPa, the cement presented herein is comparable with the non degradable polymeric counterparts and the strongest hydroxyapatite cements, and is close in strength of cortical bone. Furthermore, it has a high injectability (>90%) and a setting time of approximately 17 minutes. A cement comprising these properties has great potential of changing the future clinical indications for calcium phosphate cements, and could potentially reduce the use of non-degradable polymeric cements.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114231213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-23DOI: 10.4172/2090-5025.1000073
A. Saito, E. Saito, Y. Ueda, Y. Shibukawa, Yoshiyuki Honma, Tomomi Takahashi, M. Kimura, Y. Kuboki, Hiroshi ka
Background: The pore characteristics of bone graft materials play an important role in bone regeneration. Previous studies have reported that a pore size of 100 ~ 400 μm effectively induces vascular invasion and cell population within the materials. Many graft materials used recently have macropore (200 ~ 600 μm) or micropore (0.1 ~ 1 μm) structures. We devised a bone material with a tunnel pipe structure and pore size of 300 μm. The present study evaluated periodontal healing following implantation of this new bone graft material in furcation class III defects. Methods: Thirty mandibular premolar teeth of five beagles were used. After class III furcation defects were surgically created, each furcation was randomly treated with: 1) β-TCP with a tunnel pipe structure (tunnel group) (n=10); 2) Granular β-TCP (granular group) (n=10); and 3) No implant material (control group) (n=10). The dogs were sacrificed 8 weeks post-surgery and healing was evaluated histologically. Results: In the tunnel group, down growth of junctional epithelium was significantly less than that in the other two groups (P <0.01) and bone formation and blood capillary invasion were observed in the inner part of pores of the implanted material in the furcation. However, little bone formation was observed between the granules in the granular group. Conclusion: β- TCP with a tunnel pipe structure and pore size of 300 μm promotes bone regeneration and new cementum formation in class III furcation defects.
{"title":"Effect of Tunnel Structure of β-TCP on Periodontal Repair in Class III Furcation Defects in Dogs","authors":"A. Saito, E. Saito, Y. Ueda, Y. Shibukawa, Yoshiyuki Honma, Tomomi Takahashi, M. Kimura, Y. Kuboki, Hiroshi ka","doi":"10.4172/2090-5025.1000073","DOIUrl":"https://doi.org/10.4172/2090-5025.1000073","url":null,"abstract":"Background: The pore characteristics of bone graft materials play an important role in bone regeneration. Previous studies have reported that a pore size of 100 ~ 400 μm effectively induces vascular invasion and cell population within the materials. Many graft materials used recently have macropore (200 ~ 600 μm) or micropore (0.1 ~ 1 μm) structures. We devised a bone material with a tunnel pipe structure and pore size of 300 μm. The present study evaluated periodontal healing following implantation of this new bone graft material in furcation class III defects. Methods: Thirty mandibular premolar teeth of five beagles were used. After class III furcation defects were surgically created, each furcation was randomly treated with: 1) β-TCP with a tunnel pipe structure (tunnel group) (n=10); 2) Granular β-TCP (granular group) (n=10); and 3) No implant material (control group) (n=10). The dogs were sacrificed 8 weeks post-surgery and healing was evaluated histologically. Results: In the tunnel group, down growth of junctional epithelium was significantly less than that in the other two groups (P <0.01) and bone formation and blood capillary invasion were observed in the inner part of pores of the implanted material in the furcation. However, little bone formation was observed between the granules in the granular group. Conclusion: β- TCP with a tunnel pipe structure and pore size of 300 μm promotes bone regeneration and new cementum formation in class III furcation defects.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125226339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-11-16DOI: 10.4172/2090-5025.1000070
J. Åberg, Johanna Unosson, H. Engqvist
Premixed calcium phosphate cements (pCPC), where glycerol is used instead of water as mixing liquid, present better handling characteristics than water-based cements. However, the setting mechanisms of pCPC have not been described thoroughly. The aim of this paper is to increase the understanding of the setting mechanism of pCPC. The investigated cement starts to set when glycerol is exchanged with water via diffusion of glycerol out to the surrounding body fluid and water into the material. To better understand the water-glycerol exchange a method was developed where the setting depth of the cement was measured over time. Thermo gravimetric analysis (TGA) was used to determine the liquid exchange rate during setting. To study the influence of temperature on the crystalline end product, pCPC and water-mixed calcium phosphate cement (wCPC) were set at different temperatures and analyzed with X-ray diffraction (XRD). The setting depth measurements showed that the set layer of the pCPC grew with a speed proportional to t0.51 at 37°C. TGA results furthermore showed that less than 10% of the glycerol remained after 16 hours. Setting of pCPC at different temperatures showed that mainly brushite was formed at 5°C, a mixture of brushite and monetite at 21°C and mainly monetite at 37°C. It furthermore showed that brushite was the main phase after setting of wCPC, but some monetite was present in these cements. The study presents a new method for evaluation of pCPC that increases the understanding of their setting mechanism. Furthermore, the XRD results indicate that storage at 5°C could improve the shelf life of acidic pCPC.
{"title":"Setting Mechanisms of an Acidic Premixed Calcium Phosphate Cement","authors":"J. Åberg, Johanna Unosson, H. Engqvist","doi":"10.4172/2090-5025.1000070","DOIUrl":"https://doi.org/10.4172/2090-5025.1000070","url":null,"abstract":"Premixed calcium phosphate cements (pCPC), where glycerol is used instead of water as mixing liquid, present better handling characteristics than water-based cements. However, the setting mechanisms of pCPC have not been described thoroughly. The aim of this paper is to increase the understanding of the setting mechanism of pCPC. The investigated cement starts to set when glycerol is exchanged with water via diffusion of glycerol out to the surrounding body fluid and water into the material. To better understand the water-glycerol exchange a method was developed where the setting depth of the cement was measured over time. Thermo gravimetric analysis (TGA) was used to determine the liquid exchange rate during setting. To study the influence of temperature on the crystalline end product, pCPC and water-mixed calcium phosphate cement (wCPC) were set at different temperatures and analyzed with X-ray diffraction (XRD). The setting depth measurements showed that the set layer of the pCPC grew with a speed proportional to t0.51 at 37°C. TGA results furthermore showed that less than 10% of the glycerol remained after 16 hours. Setting of pCPC at different temperatures showed that mainly brushite was formed at 5°C, a mixture of brushite and monetite at 21°C and mainly monetite at 37°C. It furthermore showed that brushite was the main phase after setting of wCPC, but some monetite was present in these cements. The study presents a new method for evaluation of pCPC that increases the understanding of their setting mechanism. Furthermore, the XRD results indicate that storage at 5°C could improve the shelf life of acidic pCPC.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123894129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-10-24DOI: 10.4172/2090-5025.S1-015
M. Tafu, T. Masutani, Y. Takemura, T. Toshima, T. Chohji
DCPD, dicalcium phosphate dihydrate (CaHPO4•2H2O) reacts with fluoride ion in an aqueous solution, and forms fluorapatite (FAp, Ca10(PO4)6F2). In previous study, we have found that DCPD does not react with fluoride ion directly, but show few hours of induction period by reaction with fluoride. In this study, effect of hydroxyapatite (HA, Ca10(PO4)6(OH)2) on the reactivity of DCPD with fluoride ion was investigated. By mixing HA with DCPD, it was appeared that the induction period of the reaction was shortened. Morphology of the obtained FAp was similar to HA paricles. We carried on coating of HA on the DCPD particle by soaking DCPD in simulated body fluid (SBF, Kokubo Solution). By coating HA on DCPD particles, particle morphology of the obtained FAp was consistency to the DCPD particles. These results suggest that the shape and particle size of FAp after reaction of DCPD is controllable by DCPD particle as template, and coating with HA.
{"title":"Effect of Hydroxyapatite on Reaction of Dicalcium Phosphate Dihydrate DCPD) and Fluoride Ion","authors":"M. Tafu, T. Masutani, Y. Takemura, T. Toshima, T. Chohji","doi":"10.4172/2090-5025.S1-015","DOIUrl":"https://doi.org/10.4172/2090-5025.S1-015","url":null,"abstract":"DCPD, dicalcium phosphate dihydrate (CaHPO4•2H2O) reacts with fluoride ion in an aqueous solution, and forms fluorapatite (FAp, Ca10(PO4)6F2). In previous study, we have found that DCPD does not react with fluoride ion directly, but show few hours of induction period by reaction with fluoride. In this study, effect of hydroxyapatite (HA, Ca10(PO4)6(OH)2) on the reactivity of DCPD with fluoride ion was investigated. By mixing HA with DCPD, it was appeared that the induction period of the reaction was shortened. Morphology of the obtained FAp was similar to HA paricles. We carried on coating of HA on the DCPD particle by soaking DCPD in simulated body fluid (SBF, Kokubo Solution). By coating HA on DCPD particles, particle morphology of the obtained FAp was consistency to the DCPD particles. These results suggest that the shape and particle size of FAp after reaction of DCPD is controllable by DCPD particle as template, and coating with HA.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134644735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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