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Analysis of the Responses to Covid-19 in Australia, New Zealand, and Indonesia: the tale of the three Island States 分析澳大利亚、新西兰和印度尼西亚应对Covid-19的措施:三个岛国的故事
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.21.15.825
Qiuli Chen
Objective: At the end of 2019, a new pneumonia disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first spreading in Wuhan, China, and has continued to spread throughout the world. On March 11, 2020, the World Health Organization declared it was a pandemic. Many countries are aware of the risks of the novel coronavirus and have adopted different measures to contain the spread of the virus. However, the spread of the virus and its impact is variable across countries including Australia, New Zealand, and Indonesia. This paper aims to compare and contrast the epidemics in Australia, New Zealand, and Indonesia, then identify the containment strategies in these countries in order to facilitate cross-country learning. Methods: We conducted a mixed-methods study to understand the epidemic and explain the variability of the epidemic in these three Island States. Results: We have found that Australia and New Zealand have implemented public health measures, including good governance of the epidemics, communication, social distancing and personal hygiene measures, and provided sufficient medical services. On the contrary, these measures are either non-existent or implemented inadequately in Indonesia. Conclusions and implications for public health: We argue that the implementation of these public health measures and provision of medical services are all necessary to control the COVID-19 epidemics in Indonesia and other countries.
目的:2019年底,一种由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的新型肺炎疾病首次在中国武汉蔓延,并继续在全球蔓延。2020年3月11日,世界卫生组织宣布这是一场大流行。许多国家都意识到新型冠状病毒的风险,并采取了不同的措施来遏制病毒的传播。然而,病毒的传播及其影响在澳大利亚、新西兰和印度尼西亚等国家有所不同。本文旨在比较和对比澳大利亚、新西兰和印度尼西亚的流行病,然后确定这些国家的遏制战略,以便于跨国学习。方法:我们进行了一项混合方法研究,以了解这一流行病并解释这三个岛屿国家流行病的变异性。结果:我们发现澳大利亚和新西兰实施了公共卫生措施,包括对流行病的良好治理、沟通、保持社交距离和个人卫生措施,并提供了充足的医疗服务。相反,这些措施在印度尼西亚要么不存在,要么执行得不充分。结论和对公共卫生的影响:我们认为,实施这些公共卫生措施和提供医疗服务对于控制印度尼西亚和其他国家的COVID-19流行病都是必要的。
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引用次数: 0
Burden of Diarrheal Disease among under Five Children in Ethiopia, 2000-2016: Findings from the Global Health Estimates 2016 2000-2016年埃塞俄比亚五岁以下儿童腹泻病负担:2016年全球卫生估计的调查结果
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.1.801
Yibeltal Mesfin, Muche Argaw
Introduction: Globally diarrhea among under five children remains one of the high burden diseases particularly in developing countries. Ethiopia is one of the sub-Saharan countries highly under five mortality due to diarrhea. Ethiopia has made remarkable progress in reducing child mortality over the last two decades. However, the under-5 mortality and morbidity rate related to diarrhea still magnificently a burden. Objective: This study aimed to assess the burden of diarrheal for under five children in terms of death and Disability-Adjusted Life Years lost (DALY) between 2000 and 2016. Patients and methods: The research used data from Global Health Estimate 2016; that originally collected the information through vital registration, verbal autopsy, surveys, reports, published scientific articles, Global Burden of Disease study (GBD 2016) and modeling. The magnitude of Diarrheal disease death was estimated 14,894 under five children in 2016. Death from diarrheal disease has also contributed to 38.4% (14894/38777) of deaths from infectious and parasitic diseases and 7.96% (14894/187,065) of the total death reported by the same year. Meanwhile, YLD, YLL and DALYs for under five children were 61,709 and 1408.4 thousand respectively in 2016. Themagnitudeof deaths due to diarrheal disease was declined by 76.7% from the2000’s record of 49,021 deaths within 16 years. In 2016, Mortality due to Diarrheal disease was highest among males. Of the 14,894 diarrheal disease related mortalities, more than 1405 deaths were among males. Conclusion: Even if the burden of diarrhea for under five mortality is sharply declining in Ethiopia; but, it still remained one of the public health problems and second leading cause of morbidity. Therefore, strengthening hand washing practice and accessing prevention program is important to eliminate death within the target period.
导言:全球五岁以下儿童腹泻仍然是高负担疾病之一,特别是在发展中国家。埃塞俄比亚是撒哈拉以南五岁以下儿童腹泻死亡率很高的国家之一。过去二十年来,埃塞俄比亚在降低儿童死亡率方面取得了显著进展。然而,与腹泻有关的5岁以下儿童死亡率和发病率仍然是一个巨大的负担。目的:本研究旨在评估2000年至2016年间5岁以下儿童的腹泻负担,包括死亡和残疾调整生命年损失(DALY)。患者和方法:该研究使用了2016年全球卫生估计的数据;最初通过生命登记、尸检、调查、报告、发表的科学文章、全球疾病负担研究(GBD 2016)和建模收集信息。2016年,腹泻病死亡人数估计为14894名5岁以下儿童。腹泻病死亡也占传染病和寄生虫病死亡的38.4%(14894/38777),占同年报告的总死亡人数的7.96%(14894/187,065)。与此同时,2016年5岁以下儿童的YLD、YLL和DALYs分别为61,709和14.84万。与2000年16年内49021人死亡的记录相比,腹泻病死亡人数下降了76.7%。2016年,腹泻病的死亡率在男性中最高。在14,894例与腹泻有关的死亡中,超过1405例死亡是男性。结论:即使埃塞俄比亚五岁以下儿童的腹泻死亡率正在急剧下降;但是,它仍然是公共卫生问题之一,也是发病率的第二大原因。因此,加强洗手习惯和参与预防规划对于在目标期内消除死亡至关重要。
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引用次数: 2
Case Report: Acute Bilateral Sacroiliitisdue to the Use of Oral Isotretinoin 病例报告:口服异维甲酸引起的急性双侧骶髂炎
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.1.787
Gustavo Junho Toledo, Mateus Gomes Polo, A. Basso
Isotretinoin is a retinoid indicated for the treatment of acne and has been associated with several effects, including muscularskeletal symptoms such as arthritis, arthralgia and myalgia. The development of sacroiliitis is a rare side effect and a small number of cases have been described in the literature. The pacient M.G.P., 17 years old, male, was diagnosed with sacroiliitis after having started using isotretinoin, he presented serology negative for HLA-B27 and did not have any other infectious predispositions for the development of sacroiliitis. From the second week of interruption of isotretinoin use the symptomatology was significantly reduced.
异维甲酸是一种类维甲酸,用于治疗痤疮,并与多种效果有关,包括肌肉骨骼症状,如关节炎、关节痛和肌痛。骶髂炎的发展是一种罕见的副作用,少数病例已在文献中描述。患者m.g.p., 17岁,男性,在开始使用异维a酸后被诊断为骶髂炎,他的HLA-B27血清学呈阴性,并且没有任何其他导致骶髂炎的感染性易感性。从中断异维甲酸使用的第二周起,症状明显减轻。
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引用次数: 0
The Interconnection between Masks and Oral Health 口罩与口腔健康的关系
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.1.794
E. Itodo
In healthy individuals, the immune system processes pathogens with a natural immune response that is mild and non-lethal [1];however in diseased tissues like the gum disease (Periodontitis), the immune system is compromised- which overreact to affect other organs and tissues During the Spanish flu pandemic in 1918-1919, common people, not just medical professionals were mandated to wear gauze face mask to limit the spread of the disease, and non-compliance led to tines, public ridicule and sometimes jail time [3] The oral cavity supports about 700 bacterial which are involved in the differentiation and maturation of immune cells, maintenance of the immune system and balance between pro-inflammatory and anti-inflammatory processes in the immune cells which are basically Neutrophils, T cells, B cells, monocytes, macrophages dendritic cells
在健康个体中,免疫系统以一种温和的、非致命性的自然免疫反应处理病原体[1];然而,在牙龈疾病(牙周炎)等病变组织中,免疫系统受到损害——反应过度影响其他器官和组织。在1918-1919年的西班牙流感大流行期间,不仅仅是医疗专业人员,普通民众都被要求戴上纱布口罩,以限制疾病的传播,不遵守这一规定导致了多次死亡。[3]口腔中大约有700种细菌,这些细菌参与免疫细胞的分化和成熟,维持免疫系统以及免疫细胞的促炎和抗炎过程的平衡,这些免疫细胞主要是中性粒细胞、T细胞、B细胞、单核细胞、巨噬细胞、树突状细胞
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引用次数: 0
Epidemiology of Community Acquired Pneumonia in Ethiopia: a Review Article 埃塞俄比亚社区获得性肺炎流行病学综述
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.1.799
Temesgen Aferu
Community acquired pneumonia is among the major reasons of hospital visit and mortality in Ethiopia, especially in children younger than five and the implication of this infection on health and economy of the country is concerning. Against this back ground, the objective of this work was to systematically review issues related to the epidemiology of community acquired pneumonia in Ethiopia. A review and identification of literatures published between 2000 and 2015 was carried out. Search engines like Google, Google scholar and Pub Med were used to access relevant materials online. Accordingly, 47 articles, reports and other documents identified of which 39 (34 articles and 5 reports) were included in the review. The literatures addressed various issues/problems related to the epidemiology of community acquired pneumonia. This infection continued to be one of the leading causes of hospital admissions and death in Ethiopia, especially in children less than five years of age. Services being delivered at the facility and community level to overcome the challenges of this infection are showing encouraging results and hence need to be sustained.
在埃塞俄比亚,社区获得性肺炎是住院和死亡的主要原因之一,特别是在五岁以下儿童中,这种感染对该国的健康和经济的影响令人担忧。在此背景下,这项工作的目的是系统地审查与埃塞俄比亚社区获得性肺炎流行病学有关的问题。对2000年至2015年间发表的文献进行了回顾和鉴定。使用Google、Google scholar和Pub Med等搜索引擎在线获取相关资料。因此,审查中列入了47条、报告和其他文件,其中39条(34条和5份报告)。文献讨论了与社区获得性肺炎流行病学相关的各种问题。这种感染仍然是埃塞俄比亚住院和死亡的主要原因之一,特别是在五岁以下儿童中。在设施和社区一级为克服这种感染的挑战而提供的服务正在显示出令人鼓舞的结果,因此需要持续下去。
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引用次数: 1
Alternate Method of Scoring Euroqol Five-Dimensional Sca Euroqol五维Sca评分的替代方法
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.21.15.847
S. Chakrabartty
Objectives: A simple method of numerical scoring of value-sets emerging from EuroQol five-dimensional questionnaires is proposed satisfying desired properties including meaningful comparison of patients and group of patients across time and space. Methods: Data driven weights are assigned to different levels of different dimensions and continuous scores (Y)corresponding to a health state are obtained as weighted sum. Y-scores are further transformed by linear transformations to P-scores ∈ [1,100] following Normal distribution. Illustration of the proposed method of scoring health states and its properties are given with a hypothetical data Results: The method helps in assessment of health profile, progress/deterioration with time, classifying and ranking of a group of patients, meaningful comparisons and application of statistical techniques in parametric set up along with computation of treatment effectiveness, reliability avoiding unidimensionality assumption. The method may work best for sample of patients suffering from same disease Conclusions: The approach makes no assumption about distributions of dimension/ level scores. The proposed simple measures will help the researchers and practitioners to make meaningful analysis and draw meaningful conclusions. The proposed scoring method is applicable for EQ-5D-5L, EQ-5D-3L and EQ-5D-Y. Future studies suggested on psychometric properties of the proposed scoring system.
目的:提出一种简单的数值评分方法,对EuroQol五维问卷中出现的值集进行评分,以满足患者和患者群体跨时间和空间的有意义的比较。方法:将数据驱动的权重赋给不同维度的不同层次,得到健康状态对应的连续得分(Y)作为加权和。y分数进一步通过线性变换变换为p分数∈[1100],服从正态分布。结果:该方法有助于评估健康状况,随时间的进展/恶化,对一组患者进行分类和排名,有意义的比较,并在参数设置和治疗效果计算中应用统计技术,可靠性避免了单维假设。结论:该方法没有对维度/水平评分的分布作任何假设。提出的简单措施将有助于研究者和从业者进行有意义的分析,得出有意义的结论。本文提出的评分方法适用于EQ-5D-5L、EQ-5D-3L和EQ-5D-Y。未来的研究建议对所提出的评分系统的心理测量特性。
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引用次数: 1
Designing a Multi-Epitope Vaccine against Human Cytomegalovirus: an Immunoinformatics Approach 设计抗人巨细胞病毒多表位疫苗:免疫信息学方法
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.3.816
Imran Hossain
“Cytomegalovirus (CMV) is identified as the most frequent inborn viral contagion in people and an important matter of morbidity and destruction in immunocompromised owners”. Cytomegalovirus is a typical herpes virus. Also distinguished as HCMV or human herpesvirus 5 (HHV-5). Once tainted, the human body holds the virus for life. CMV settles from person to person over body liquids, like blood, saliva, urine, semen and breast milk. “The Centers for Disease Control and Prevention organization” (CDC) predicted that around 50% of grown-ups in the United States have incurred the virus by forty years old. It afflicts men and women fairly, at any life and notwithstanding of ethnicity. Fever, wetness, tiredness, restlessness, sore throat, enlarged glands, muscle strain, low desire and loss of weight are the obvious indications. But recurring and fundamental CMV have more dangerous symptoms and critical conditions like as jaundice, fever, pneumonia, cold, spots under the surface body, Purple color surface stains, a blemish, or all, developed liver, kidney, large spleen, low birth weight, breakdowns etc. Notwithstanding these debilitating maladies, no prescription to prevent them improvement or treatment is open till now. That’s why we proposed to express a multi-epitope vaccine upon CMV by employing an Immuno bioinformatics road. For this desire, we practised the Human CMV spike protein to ascertain the dominant. After study of the specification of these epitopes we selected only six epitopes to create the desire vaccine against the human Cytomegalovirus. All features of a perfect vaccine was present of our designed vaccine such as non-toxin, non-allergenic and highly soluble etc. Moreover, our created vaccine showed the excellent score in all physiochemical and in lifetimein the host cell.
巨细胞病毒(CMV)被认为是人类中最常见的先天性病毒传染病,也是免疫功能低下者发病和破坏的重要因素。巨细胞病毒是典型的疱疹病毒。也被区分为HCMV或人类疱疹病毒5 (HHV-5)。一旦被感染,人体就会终生携带病毒。巨细胞病毒通过血液、唾液、尿液、精液和母乳等体液在人与人之间传播。美国疾病控制与预防中心(CDC)预测,美国约有50%的成年人在40岁之前感染了这种病毒。它公平地折磨着男人和女人,不分种族,不分生命。发烧、潮湿、疲倦、不安、喉咙痛、腺体肿大、肌肉劳损、性欲低下和体重减轻是明显的症状。但复发性和基础性巨细胞病毒有更危险的症状和严重的情况,如黄疸,发烧,肺炎,感冒,体表下的斑点,紫色表面斑点,瑕疵,或全部,肝,肾,大脾,低出生体重,崩溃等。尽管有这些使人衰弱的疾病,但到目前为止还没有预防或治疗这些疾病的处方。因此,我们提出利用免疫生物信息学方法在巨细胞病毒上表达多表位疫苗。为此,我们对人类巨细胞病毒刺突蛋白进行了实验,以确定其显性。通过对这些抗原表位的研究,我们只选择了6个抗原表位来制备抗人巨细胞病毒的疫苗。所设计的疫苗具有无毒、无致敏性、高溶性等完美疫苗的特点。此外,我们制备的疫苗在宿主细胞内的各项理化指标和寿命指标均表现出优异的成绩。
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引用次数: 0
Potential Health Effects due to Exposure of Criteria Air Pollutants 接触标准空气污染物对健康的潜在影响
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.21.15.851
P. Chaitanya, E. Upadhyay, Singh Dd, Singh
Air pollution causes serious health impacts because one-third of deaths occur due to exposure to air pollutants. The pollutant has both acute and chronic effects which go deep into the organ systems and deposit into tissues and causes long-term and short-term effects on the human body. The present review will develop an understanding of the current state of knowledge for potential health effects concerning the dose-response relationship between exposure to criteria air pollutants and health risk assessment. High-quality scientific research papers were drawn with consideration of experimental design, conduct, and reported for analyzing the exposures to criteria air pollutants via inhalation which imitates the expected route of exposure to humans. The majority of evidence refers to effects on the respiratory system, cardiovascular, inflammatory, and blood-affecting diseases. The critical assessment investigated the effects on vulnerable subjects and stimulated diseases which are classified as physiological and psychological diseases and their effects.
空气污染对健康造成严重影响,因为三分之一的死亡是由于接触空气污染物造成的。污染物具有急性和慢性两种作用,可深入人体器官系统,沉积于组织中,对人体产生长期和短期的影响。本次审查将使人们了解接触标准空气污染物与健康风险评估之间的剂量-反应关系方面潜在健康影响的知识现状。高质量的科学研究论文是在考虑实验设计、实施和报告的情况下,通过吸入模拟人类暴露的预期途径来分析标准空气污染物的暴露。大多数证据是指对呼吸系统、心血管、炎症和影响血液的疾病的影响。关键评价研究了对易感对象的影响和被刺激的生理和心理疾病及其影响。
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引用次数: 0
Effects of Disinfection on Orthodontic Plaster Models 消毒对正畸石膏模型的影响
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.2.808
N. Beleva
Background and aims: The purpose of this study was to evaluate the effects of disinfection and different brands of alginate impression material on the accuracy of orthodontic stone models. Materials and methods: Six different alginate impression materials and four different disinfectants were included in the study. A total of 168 impressions were taken and divided into 24 groups. Fifty-six impressions taken with extended pour-type alginates were kept in sealed plastic bags for four days and then poured. One hundred and twelve impressions were poured immediately after the disinfection process. A 3-D laser scanner was used for dimensional measurements on the vestibule surface area, while the mesial–distal width of the right upper molar was measured with screen caliper software. Results: This study showed that the contraction of models varied significantly depending on the alginate material and disinfectant. Evaluation of the upper first molar showed that molar contraction varied between 1.2 and 3.2% in dimension. According to molar data, the best accuracy was obtained from Blueprint-Zeta, while the worst was obtained from the Hydrogum Ext Pour–NaOCl alginate– disinfectant combination. Two-way ANOVA of data from the vestibule surface area showed significant results for all pairwise comparisons of alginate and disinfectant materials and their interactions. According to the results of the two-way ANOVA, the best accuracy was obtained from Hydrogum and Blueprint alginates with Unident disinfectant. The worst accuracy was obtained from Hydrogum Ext Pour alginate with Zeta disinfectant. Conclusions: The dimensions of stone models produced from disinfectant-treated alginate impression materials demonstrate various degrees of contraction.
背景与目的:本研究的目的是评估消毒和不同品牌藻酸盐印模材料对正畸石模型准确性的影响。材料与方法:采用6种不同的藻酸盐印模材料和4种不同的消毒剂进行研究。共有168个印象被分成24组。56个用加长式海藻酸盐拍摄的印痕在密封塑料袋中保存4天,然后倒入。在消毒过程后立即倒入112个印痕。使用三维激光扫描仪对前庭表面积进行尺寸测量,使用屏幕卡尺软件测量右上磨牙的中、远端宽度。结果:本研究表明,模型的收缩随藻酸盐材料和消毒剂的不同而有显著差异。对上颌第一磨牙的评估显示磨牙收缩尺寸在1.2 - 3.2%之间。根据摩尔数据,Blueprint-Zeta法测定的准确度最好,而Hydrogum Ext - pur - naocl海藻酸盐-消毒剂组合测定的准确度最差。来自前厅表面积数据的双向方差分析显示,海藻酸盐和消毒剂材料及其相互作用的所有两两比较都有显著结果。双向方差分析结果表明,Unident消毒液对水胶和蓝本海藻酸盐的去除率最高。Zeta消毒剂对海藻酸氢胶的准确度最差。结论:用经过消毒处理的藻酸盐印模材料制作的石材模型尺寸表现出不同程度的收缩。
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引用次数: 0
Adverse Maternal Outcomes of Advanced Maternal Age Pregnancy in Northwest Ethiopia 2020: Comparative Cross Sectional Study 埃塞俄比亚西北部2020年高龄妊娠的不良孕产妇结局:比较横断面研究
Pub Date : 2021-01-01 DOI: 10.36648/1791-809X.15.2.809
Temesgen Getaneh, A. Negesse, Getenet Dessie, Melaku Desta, Moges Agazhe
Objective: advanced maternal age is a substantial risk for different adverse maternal outcomes, responsible for maternal morbidity and mortality. Despite these adverse maternal outcomes of advanced maternal age pregnancy, the research focus given to maternal outcomes of these populations is limited specifically, no study was done in the study area. Therefore, this comparative cross-sectional study was conducted in Awi Zone public hospitals, Northwest Ethiopia to compare adverse maternal outcomes among adult and advanced maternal aged pregnancy. Systematic random sampling was employed to select 447 women. Data were analyzed using SPSS version 25. Result: The odds of gestational diabetic melitus (AOR=4.36, 95% CI: 1.18, 6.14), severe preeclampsia (AOR=2.42, 95% CI: 1.30, 4.50), antepartum hemorrhage (AOR=3.10, 95% CI: 1.47, 6.54) and cesarean delivery (AOR=3.07, 95% CI: 1.52, 6.19) were significantly higher among advanced aged women. Women at advanced aged had a higher risk of adverse maternal outcomes when compared to adult aged women. Therefore, counseling to have child in adult aged period, provision of quality family planning and perinatal care should be addressed.
目的:高龄产妇是各种不良产妇结局的重大风险因素,是造成产妇发病率和死亡率的原因。尽管高龄妊娠有这些不良的产妇结局,但对这些人群的产妇结局的研究重点是有限的,没有在研究领域进行研究。因此,本比较横断面研究在埃塞俄比亚西北部的Awi区公立医院进行,以比较成人和高龄妊娠产妇的不良产妇结局。采用系统随机抽样的方法,抽取447名女性。数据分析采用SPSS version 25。结果:高龄妇女发生妊娠期糖尿病(AOR=4.36, 95% CI: 1.18, 6.14)、重度子痫前期(AOR=2.42, 95% CI: 1.30, 4.50)、产前出血(AOR=3.10, 95% CI: 1.47, 6.54)、剖宫产(AOR=3.07, 95% CI: 1.52, 6.19)的几率显著高于高龄妇女。与成年妇女相比,高龄妇女发生不良孕产结局的风险更高。因此,在成年期生育的咨询,提供优质的计划生育和围产期护理应得到重视。
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引用次数: 0
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