Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.834
Jinlei Ye, Shilei Wang, Shuo Liu, Ying Chen, S. Shen, Qiping Zheng, Zhi-lei Cui, Lichun Sun
Nasopharyngeal carcinoma (NPC) is a complex epithelial malignancy caused by both internal and environmental factors. Among them, Epstein–Barr virus (EBV) is a definitive etiological factor. The current therapeutic regimen for NPC is far from ideal and recurrence is commonly seen in patients after conventional radio and/or chemotherapy. We have thereby set out to develop new treatments for this deadly disease. Having analyzed a number of nasopharyngeal tissue and cell samples, we found that the level of somatostatin receptors (SSTRs) was positively correlated with EBV infection. Further, SSTR2 is the dominant SSTR isoform expressed in the EBV-positive (EBV (+)) NPC cells, a potential target for precise delivery of therapeutic agents. Cytotoxic effects of small molecule drugs including ansamitocin P-3 (AP-3), camptothecin and colchicine were subsequently evaluated in NPC cells. We found that AP-3 exhibits its strong anti-NPC activities with the IC50 values being 0.07 nM in EBV (+) NPC C666-1 cells and 0.09 nM in EBV (-) NPC CNE2 cells. In the xenograft animal model, AP-3 further shows inhibitory effects on NPC growth. These findings indicated that AP-3’s activity is not related to EBV in NPC cells. Thus, we proposed that SSTR2- specific delivery of AP-3 via linking AP-3 to somatostatin is likely a viable option to treat the EBV (+) NPC patients.
{"title":"The Therapeutic Possibility of EBV-Positive Nasopharyngeal Carcinoma through Targeting Somatostatin Receptors","authors":"Jinlei Ye, Shilei Wang, Shuo Liu, Ying Chen, S. Shen, Qiping Zheng, Zhi-lei Cui, Lichun Sun","doi":"10.36648/1791-809X.21.15.834","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.834","url":null,"abstract":"Nasopharyngeal carcinoma (NPC) is a complex epithelial malignancy caused by both internal and environmental factors. Among them, Epstein–Barr virus (EBV) is a definitive etiological factor. The current therapeutic regimen for NPC is far from ideal and recurrence is commonly seen in patients after conventional radio and/or chemotherapy. We have thereby set out to develop new treatments for this deadly disease. Having analyzed a number of nasopharyngeal tissue and cell samples, we found that the level of somatostatin receptors (SSTRs) was positively correlated with EBV infection. Further, SSTR2 is the dominant SSTR isoform expressed in the EBV-positive (EBV (+)) NPC cells, a potential target for precise delivery of therapeutic agents. Cytotoxic effects of small molecule drugs including ansamitocin P-3 (AP-3), camptothecin and colchicine were subsequently evaluated in NPC cells. We found that AP-3 exhibits its strong anti-NPC activities with the IC50 values being 0.07 nM in EBV (+) NPC C666-1 cells and 0.09 nM in EBV (-) NPC CNE2 cells. In the xenograft animal model, AP-3 further shows inhibitory effects on NPC growth. These findings indicated that AP-3’s activity is not related to EBV in NPC cells. Thus, we proposed that SSTR2- specific delivery of AP-3 via linking AP-3 to somatostatin is likely a viable option to treat the EBV (+) NPC patients.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76224569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.846
Matheus Santos de Sousa Fern, es, G. Santos
Aerobic training has been considered as a good strategy to improve physical conditioning, body composition and health promotion. The present study sought to analyze the influence of fasting aerobic training on the body composition of trained people. For this, a bibliographic review of the literature was carried out based on the survey of theoretical references already analyzed and published by written means such as books, theses and monographs and electronic bases such as Scielo and PubMed, seeking a clear analysis of the results requested in the body composition of individuals trained to apply fasting aerobics. In this work, it is possible to understand how fast aerobic training can influence body composition and be an alternative to reduce adipose tissue.
{"title":"The Influence of Aerobic Fasting on the Body Composition of Trained Individuals: a Mini Review","authors":"Matheus Santos de Sousa Fern, es, G. Santos","doi":"10.36648/1791-809X.21.15.846","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.846","url":null,"abstract":"Aerobic training has been considered as a good strategy to improve physical conditioning, body composition and health promotion. The present study sought to analyze the influence of fasting aerobic training on the body composition of trained people. For this, a bibliographic review of the literature was carried out based on the survey of theoretical references already analyzed and published by written means such as books, theses and monographs and electronic bases such as Scielo and PubMed, seeking a clear analysis of the results requested in the body composition of individuals trained to apply fasting aerobics. In this work, it is possible to understand how fast aerobic training can influence body composition and be an alternative to reduce adipose tissue.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86180348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.3.820
Nikos Tsoukalis-Chaikalis, S. Demsia, D. Chaniotis, F. Chaniotis
The COVID-19 (SARS-CoV-2) pandemic constitutes a major health crisis affecting numerous nations, with over 82,994,220 cases and 1,810,360 confirmed deaths reported to date. Such widespread outbreaks are associated with adverse mental health consequences. Hence, it is important to understand the extent and impact of these challenges. In this study, we conducted a Systematic Mapping Study for collecting, cataloguing, and classifying research activities that explore the phycological impact of COVID-19, including anxiety, depression, and stress which seem to be common psychological reactions to the COVID-19 pandemic. Two key research areas were explored as part of our literature review: a) observational studies, reporting on mental health symptoms in particular populations, and b) commentaries and review articles, addressing the psychological impact of COVID-19 on the general population, the healthcare workers, and the high-risk populations. There is the need for a more systematic research approach which could consider associated factors and confounders, such as demographics, sociocultural and health outcomes.
{"title":"Systematic Mapping Study of The Covid-19 Psychological Impact","authors":"Nikos Tsoukalis-Chaikalis, S. Demsia, D. Chaniotis, F. Chaniotis","doi":"10.36648/1791-809X.15.3.820","DOIUrl":"https://doi.org/10.36648/1791-809X.15.3.820","url":null,"abstract":"The COVID-19 (SARS-CoV-2) pandemic constitutes a major health crisis affecting numerous nations, with over 82,994,220 cases and 1,810,360 confirmed deaths reported to date. Such widespread outbreaks are associated with adverse mental health consequences. Hence, it is important to understand the extent and impact of these challenges. In this study, we conducted a Systematic Mapping Study for collecting, cataloguing, and classifying research activities that explore the phycological impact of COVID-19, including anxiety, depression, and stress which seem to be common psychological reactions to the COVID-19 pandemic. Two key research areas were explored as part of our literature review: a) observational studies, reporting on mental health symptoms in particular populations, and b) commentaries and review articles, addressing the psychological impact of COVID-19 on the general population, the healthcare workers, and the high-risk populations. There is the need for a more systematic research approach which could consider associated factors and confounders, such as demographics, sociocultural and health outcomes.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"2017 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86785690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Body Dysmorphic Syndrome (CDS) is a clinical entity that consists of an agonizing concern for imaginary or slight defects in appearance, this is commonly considered as an obsessive-compulsive spectrum disorder, based on the similarities it has with this condition. Clinically, it is underdiagnosed because many patients are shy about showing their secondary problem, since most of the time it derives from the altered perception of the skin, hair or nose. However, the disorder can point to various aspects of the patient's appearance throughout his life, it arises if one believes himself to be ugly, deformed or unattractive in the presence of no or minimal culturally acceptable physical deformity and is related to strong feelings of shame accompanied by repetitive behaviors such as checking in the mirror, camouflage of "defects", among others. The World Health Organization (WHO) has considered this disorder as one of the ten most disabling diseases, since the person can avoid social or personal contact. For this reason, CDS is currently considered one of the potentially fatal diseases due to abuse of surgical (cosmetic) procedures and the high rate of suicide attempts with 80% in patients with CDS generate suicidal ideation, but 50% run it.
{"title":"Dysmorphic Syndrome or Body DysmorphicDisorder: A Major Underdiagnosed MentalHealth Problem","authors":"Wendy Sanchez Cañate, Lazaro Valdelamar Gale, Katerine Perez Mejia, Tatiana Rodriguez Jimenez, Francesc Salgado, Heliana Padilla Santos, Nelson Villalba Ordosgoitia","doi":"10.36648/1791-809X.15.842","DOIUrl":"https://doi.org/10.36648/1791-809X.15.842","url":null,"abstract":"The Body Dysmorphic Syndrome (CDS) is a clinical entity that consists of an agonizing concern for imaginary or slight defects in appearance, this is commonly considered as an obsessive-compulsive spectrum disorder, based on the similarities it has with this condition. Clinically, it is underdiagnosed because many patients are shy about showing their secondary problem, since most of the time it derives from the altered perception of the skin, hair or nose. However, the disorder can point to various aspects of the patient's appearance throughout his life, it arises if one believes himself to be ugly, deformed or unattractive in the presence of no or minimal culturally acceptable physical deformity and is related to strong feelings of shame accompanied by repetitive behaviors such as checking in the mirror, camouflage of \"defects\", among others. The World Health Organization (WHO) has considered this disorder as one of the ten most disabling diseases, since the person can avoid social or personal contact. For this reason, CDS is currently considered one of the potentially fatal diseases due to abuse of surgical (cosmetic) procedures and the high rate of suicide attempts with 80% in patients with CDS generate suicidal ideation, but 50% run it.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84737091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.S3.003
Tegan Zacchaeus Victor Ijaja John Mosugu
The COVID-19 pandemic is affecting lives and exposing weaknesses in health systems across the globe. The importance of health governance in delivering proper and effective services worldwide cannot be overemphasized. It has become apparent that the old ways - vertical and centralized methods of governance - of leadership are not the most effective during the COVID-19 pandemic. As such, there is a need for newer and more innovative methods - collective action and adaptation to change - of ensuring that healthcare can be delivered effectively amid the ongoing chaos and ambiguity. NGOs have also successfully mitigated the effects of the pandemic by introducing/ incorporating healthy behaviors into public messages (washing of hands and social distancing), spearheading advocacy efforts, and serving as the link between the local communities and bilateral/multilateral donors. These coordinated efforts have helped in reducing the spread of virus which has led to lower morbidity rates. Furthermore, Africa has been able to escape the heavy impact of the pandemic due to its adherence to isolation measures coupled with preventive guidelines, public mandates, and bans on domestic/international travel. This paper seeks to explore why effective health governance is important during the pandemic, the roles of NGOs, and lessons learnt thus far.
{"title":"Mitigating the Effects of Covid-19 Through Global Health Governance","authors":"Tegan Zacchaeus Victor Ijaja John Mosugu","doi":"10.36648/1791-809X.21.S3.003","DOIUrl":"https://doi.org/10.36648/1791-809X.21.S3.003","url":null,"abstract":"The COVID-19 pandemic is affecting lives and exposing weaknesses in health systems across the globe. The importance of health governance in delivering proper and effective services worldwide cannot be overemphasized. It has become apparent that the old ways - vertical and centralized methods of governance - of leadership are not the most effective during the COVID-19 pandemic. As such, there is a need for newer and more innovative methods - collective action and adaptation to change - of ensuring that healthcare can be delivered effectively amid the ongoing chaos and ambiguity. NGOs have also successfully mitigated the effects of the pandemic by introducing/ incorporating healthy behaviors into public messages (washing of hands and social distancing), spearheading advocacy efforts, and serving as the link between the local communities and bilateral/multilateral donors. These coordinated efforts have helped in reducing the spread of virus which has led to lower morbidity rates. Furthermore, Africa has been able to escape the heavy impact of the pandemic due to its adherence to isolation measures coupled with preventive guidelines, public mandates, and bans on domestic/international travel. This paper seeks to explore why effective health governance is important during the pandemic, the roles of NGOs, and lessons learnt thus far.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"1 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72866211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.832
Chalachew Yenew
Background: River is one of a freshwater ecosystem that plays an important role in people's living, aquatic and terrestrial living organisms, and agricultural production. Compared to other ecosystems, rivers support a disproportionately large number of plant and animal species. However, excessive human activities have busted the original ecological balance by polluting the river ecosystem. As a result, partial or total affected the structure and functions of the river ecosystem. This review aimed to investigate the major ecological restoration methods of the polluted river ecosystem. Methods: We have adopted the procedures from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The required data were collected via a literature search of MEDLINE/PubMed, Google Scholar, Science Direct, EMBASE, HINARI, and Cochrane Library from the 9th of September, 2019 to the 5th of March, 2020 using combined terms. Articles were included in our review; only if it assessed empirically and comparison and contrast between two or more different restoration methods. This review; it is mainly included published research articles, national reports, and annual reports and excluded opinion essays. Results: Commonly used methods for restoration of polluted rivers around the globe could be categorized depending on the physical, chemical, and biological characteristics of the river. Restoration methods such as channel hydromorphic, aeration, watershed action, riparian, In-stream hydromorphic, and In-stream or wetland creation restoration account for 16%, 19%, 12%, 22%, 17% and 14% of river ecosystem restoration efficiency respectively. From the restoration methods: riparian, artificial aeration and In-stream or wetland creation are preferred for restoration of chemical characteristics. For the restoration of physical characteristics; watershed action and channel hydromorphic are preferred. While for the restoration of biological characteristics; in-stream hydromorphic is the preferred one. Conclusion: Contaminated Rivers can be restored by using different restoration methods. The selection of the preferred restoration methods depends on the physical, chemical, and biological characteristics of the river.
{"title":"Key Restoration Methods of a Polluted RiverEcosystem: A Systematic Review","authors":"Chalachew Yenew","doi":"10.36648/1791-809X.21.15.832","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.832","url":null,"abstract":"Background: River is one of a freshwater ecosystem that plays an important role in people's living, aquatic and terrestrial living organisms, and agricultural production. Compared to other ecosystems, rivers support a disproportionately large number of plant and animal species. However, excessive human activities have busted the original ecological balance by polluting the river ecosystem. As a result, partial or total affected the structure and functions of the river ecosystem. This review aimed to investigate the major ecological restoration methods of the polluted river ecosystem. Methods: We have adopted the procedures from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The required data were collected via a literature search of MEDLINE/PubMed, Google Scholar, Science Direct, EMBASE, HINARI, and Cochrane Library from the 9th of September, 2019 to the 5th of March, 2020 using combined terms. Articles were included in our review; only if it assessed empirically and comparison and contrast between two or more different restoration methods. This review; it is mainly included published research articles, national reports, and annual reports and excluded opinion essays. Results: Commonly used methods for restoration of polluted rivers around the globe could be categorized depending on the physical, chemical, and biological characteristics of the river. Restoration methods such as channel hydromorphic, aeration, watershed action, riparian, In-stream hydromorphic, and In-stream or wetland creation restoration account for 16%, 19%, 12%, 22%, 17% and 14% of river ecosystem restoration efficiency respectively. From the restoration methods: riparian, artificial aeration and In-stream or wetland creation are preferred for restoration of chemical characteristics. For the restoration of physical characteristics; watershed action and channel hydromorphic are preferred. While for the restoration of biological characteristics; in-stream hydromorphic is the preferred one. Conclusion: Contaminated Rivers can be restored by using different restoration methods. The selection of the preferred restoration methods depends on the physical, chemical, and biological characteristics of the river.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84867410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.21.15.833
R. Popovian, Wayne Winegarden
While originally a clinical tool, prior authorization policies administered by pharmacy benefit managers (PBM) and insurers of biopharmaceuticals are now primarily designed to manage costs. Prior authorization requirements are associated with reduced drug spending (the financial benefit), but they also impose administrative costs on providers, insurance plans, and employer-sponsored plans. Prior authorizations also worsen patient adherence to their prescribed medicines, which is associated with increases in overall healthcare spending. This analysis develops a model utilizing published estimates to quantify the costs created by prior authorizations compared to the financial benefits as measured by the reduced drug spending. Based on our analysis, healthcare costs associated with prior authorizations exceed the benefits of reduced drug spending increasing total healthcare spending by $1.9 billion per year. While additional research evaluating the net benefit from prior authorization policies is necessary, our analysis indicates that prior authorization policies as an administrative tool cannot be justified based on their net financial impact on the healthcare sector.
{"title":"An Estimate of the Net Benefits from Prior Authorization Policies in the U.S.","authors":"R. Popovian, Wayne Winegarden","doi":"10.36648/1791-809X.21.15.833","DOIUrl":"https://doi.org/10.36648/1791-809X.21.15.833","url":null,"abstract":"While originally a clinical tool, prior authorization policies administered by pharmacy benefit managers (PBM) and insurers of biopharmaceuticals are now primarily designed to manage costs. Prior authorization requirements are associated with reduced drug spending (the financial benefit), but they also impose administrative costs on providers, insurance plans, and employer-sponsored plans. Prior authorizations also worsen patient adherence to their prescribed medicines, which is associated with increases in overall healthcare spending. This analysis develops a model utilizing published estimates to quantify the costs created by prior authorizations compared to the financial benefits as measured by the reduced drug spending. Based on our analysis, healthcare costs associated with prior authorizations exceed the benefits of reduced drug spending increasing total healthcare spending by $1.9 billion per year. While additional research evaluating the net benefit from prior authorization policies is necessary, our analysis indicates that prior authorization policies as an administrative tool cannot be justified based on their net financial impact on the healthcare sector.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80196036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.1.856
Jesús Monter Pére
Introduction: Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy due to an autoimmune process, which is triggered in most cases by a viral or bacterial infection, its incidence is 1.75/100,000 inhabitants worldwide. It is a very rare pathology and even less frequent are the cases in young women, so we carry out a review of its epidemiology, clinical manifestations, diagnostic criteria and management. Objective: In this work the case of a young adult woman with GBS is presented. Description of the case: This is a 22-year-old female patient, who was admitted for 10 days at the ESE Hospital La Divina Misericordia with a picture of approximately 1 hour of evolution consisting of dysphagia, odynophagia, asthenia, episodes of dizziness, adynamia, accompanied by a decrease in muscle strength in the upper limbs, also associated with loss of tongue sensitivity. Conclusions: GBS in young women is a rare variant. In most reports the course of the episodes is unpredictable.
{"title":"Guillain Barre vs. Miastenia Gravis as an AtypicalPresentation of SARS COV 2 By Molecular Mimic:Purpose of a Case","authors":"Jesús Monter Pére","doi":"10.36648/1791-809X.15.1.856","DOIUrl":"https://doi.org/10.36648/1791-809X.15.1.856","url":null,"abstract":"Introduction: Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy due to an autoimmune process, which is triggered in most cases by a viral or bacterial infection, its incidence is 1.75/100,000 inhabitants worldwide. It is a very rare pathology and even less frequent are the cases in young women, so we carry out a review of its epidemiology, clinical manifestations, diagnostic criteria and management. Objective: In this work the case of a young adult woman with GBS is presented. Description of the case: This is a 22-year-old female patient, who was admitted for 10 days at the ESE Hospital La Divina Misericordia with a picture of approximately 1 hour of evolution consisting of dysphagia, odynophagia, asthenia, episodes of dizziness, adynamia, accompanied by a decrease in muscle strength in the upper limbs, also associated with loss of tongue sensitivity. Conclusions: GBS in young women is a rare variant. In most reports the course of the episodes is unpredictable.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89053420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.1.785
Abulgasem Etraim, Hanan Eljabu, I. Elfortia, A. Andisha
A second trimester cervical ectopic pregnancy is a rare kind of ectopic pregnancy and is associated with a high maternal mortality rate. Early diagnosis and management of an ectopic pregnancy is considered as a principal factor to decrease the maternal mortality rate as well as to preserve the fertility of the patient. A 36 year old patient G1P0, 24 weeks with an attack of per-vaginal bleeding and abdominal pain, was diagnosed as a case of an invetable abortion. After termination of the pregnancy, intractable and uncontrolled bleeding was noticed, so a decision of lapratomy was taken and a diagnosis of cervical ectopic pregnancy was confirmed and managed with a total abdominal hysterectomy. It is recommended that staff in the obstetric and gynaecology departments should have training in the use of technology (Ultra-Sound Scan) and its application in order to eliminate possible complications.
{"title":"Delayed Diagnosis and Managementof Second Trimester Cervical EctopicPregnancy - Case Report","authors":"Abulgasem Etraim, Hanan Eljabu, I. Elfortia, A. Andisha","doi":"10.36648/1791-809X.15.1.785","DOIUrl":"https://doi.org/10.36648/1791-809X.15.1.785","url":null,"abstract":"A second trimester cervical ectopic pregnancy is a rare kind of ectopic pregnancy and is associated with a high maternal mortality rate. Early diagnosis and management of an ectopic pregnancy is considered as a principal factor to decrease the maternal mortality rate as well as to preserve the fertility of the patient. A 36 year old patient G1P0, 24 weeks with an attack of per-vaginal bleeding and abdominal pain, was diagnosed as a case of an invetable abortion. After termination of the pregnancy, intractable and uncontrolled bleeding was noticed, so a decision of lapratomy was taken and a diagnosis of cervical ectopic pregnancy was confirmed and managed with a total abdominal hysterectomy. It is recommended that staff in the obstetric and gynaecology departments should have training in the use of technology (Ultra-Sound Scan) and its application in order to eliminate possible complications.","PeriodicalId":12868,"journal":{"name":"Health science journal","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77454068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.36648/1791-809X.15.3.817
Anoop Kv, K. Devadas, Jijo Varghese
Transient elastography (TEE) is a method used for estimating liver fibrosis by measuring the liver stiffness (LSM). Aim of this study was to investigate whether TEE fibrosis scores and liver biopsy fibrosis scores are comparable. It was a Cross sectional study of patients undergoing liver biopsy because of high TEE with persistent transaminitis/normal TEE with persistent transaminitis/high TEE with normal transaminases. TEE fibrosis score of study population was compared to liver biopsy fibrosis scores, which is considered as gold standard, and patients with discordance of more than one fibrosis stage was analyzed with above mentioned variables which can affect TEE. Characteristics of the discordant population was analysed. After applying spearmanˊs correlation it was found that albumin, Total bilirubin and INR had a strong correlation with TEE values. Multiple regression analysis showed albumin and SGOT were independent predictors of Liver stiffness measurement. The discordant population was again analysed after classifying it into two groups i.e F 0-2 (minimal fibrosis) and F 3 (significant fibrosis based on biopsy). After analysis it was found that in F 0-2 group there were certain variables like SGPT, Albumin and INR which had strong correlation with TEE values. Total bilirubin and platelets had moderate correlation with TEE values. After analysing F3 group, age had strong positive correlation with TEE values. TEE was found to be better in detecting liver stiffness than liver biopsy in clinically suspected cirrhosis in this study.
瞬态弹性成像(TEE)是一种通过测量肝脏硬度(LSM)来评估肝纤维化的方法。本研究的目的是探讨TEE纤维化评分和肝活检纤维化评分是否具有可比性。这是一项横断面研究，患者接受肝活检，因为高TEE与持续性转氨炎/正常TEE与持续性转氨炎/高TEE与正常转氨酶。将研究人群TEE纤维化评分与肝活检纤维化评分进行比较，并将肝活检纤维化评分作为金标准，对多个纤维化分期不一致的患者采用上述影响TEE的变量进行分析。分析了不和谐种群的特征。应用spearman - x - s相关性发现，白蛋白、总胆红素和INR与TEE值有较强的相关性。多元回归分析显示，白蛋白和SGOT是肝硬度测量的独立预测因子。将不一致人群分为两组，即f0 -2(最小纤维化)和f3(基于活检的显著纤维化)，再次进行分析。经分析发现，f0 -2组有SGPT、Albumin、INR等变量与TEE值有较强的相关性。总胆红素和血小板与TEE值有中度相关性。经F3组分析，年龄与TEE值呈正相关。本研究发现TEE对临床疑似肝硬化患者的肝硬度检测优于肝活检。
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