Heart rhythm最新文献

Background: Early recurrence of atrial tachyarrhythmias (ERAT) is common after pulmonary vein isolation (PVI) and is traditionally attributed to transient post-procedural inflammation. With the introduction of pulsed-field ablation (PFA), the incidence and prognostic significance of ERAT compared with thermal ablation remains unknown.

Objective: To compare the incidence of ERAT during the blanking period in patients undergoing PFA versus radiofrequency (RF) ablation for atrial fibrillation (AF).

Methods: We prospectively enrolled patients undergoing first-time PVI between 2022 and 2025 at our institution. Propensity score matching was performed to address baseline imbalances and group size differences between RF and PFA PVI. The incidence of ERAT and its association with 9-month arrhythmia recurrence, defined as late recurrence of atrial tachyarrhythmias (LRAT), were analyzed.

Results: A total of 962 patients were included (420 RF, 542 PFA). Patients with ERAT were more likely to be older, have persistent AF, higher CHA₂DS₂-VASc scores, larger atria, reduced ejection fraction, and no prior antiarrhythmic drug use. After multivariable adjustment, PFA was independently associated with a lower risk of ERAT compared with RF (hazard ratio [HR] 0.61; 95% confidence interval [CI] 0.42-0.88). ERAT was strongly associated with LRAT, with a three to four-fold higher risk of atrial arrhythmias at 9 months (early ERAT: HR 3.78, p < 0.001; late ERAT: HR 4.10, p = 0.001), regardless of ablation modality.

Conclusion: PFA is associated with a significantly lower risk of ERAT compared with RF ablation. The occurrence of ERAT, irrespective of energy source, predicts a substantially higher risk of LRAT.

Background: The autonomic effects of pulsed-field ablation (PFA) remain incompletely defined. Prior work has relied on heart rate variability (HRV), which cannot differentiate sympathetic from vagal activity. We employed deceleration/acceleration capacity (DC/AC)-valid vagal/sympathetic activity measures-to evaluate autonomic changes before and after PFA for paroxysmal atrial fibrillation (PAF).

Objective: The study aimed to characterize peri-PFA changes in DC/AC in PAF patients.

Methods: This prospective study included 45 consecutive patients with PAF who experienced PFA. DC/AC and HRV were performed at baseline, immediately after ablation, and at 3-month follow-up. The relationship between HRV and DC/AC was assessed by Pearson correlation. Receiver operating characteristic analyses the predictive value of DC/AC for AF recurrence. Kaplan-Meier analysis assessed freedom from AF recurrence over 12 months in relation to autonomic indices.

Results: Pulmonary vein isolation (PVI) was successful in all patients; 91.1% exhibited intraprocedural vagal responses. DC and |AC| decreased immediately after PFA and partially recovered at 3 months (overall P<0.05 for both). Most HRV parameters had weak correlations with DC/AC (Pearson r=0.08-0.67). At 12-month, the drug-free atrial tachycardia-free rate was 75.56%. Pre-ablation DC/AC (AUC 0.63/0.64) and changes in DC/AC (AUC 0.68/0.67) were able to predict AF recurrence. Patients with lower pre-ablation |AC| and smaller ΔDC/ΔAC had significantly higher AF recurrence rates (log-rank p<0.05).

Conclusions: Our evaluation via DC/AC revealed significant alterations in autonomic activity following PFA. Furthermore, DC/AC and their trajectories demonstrated moderate predictive value for AF recurrence, underscoring the need to reconsider the impact of PFA on cardiac autonomic innervation.

Background: Antitachycardia pacing (ATP) can prevent defibrillator shocks and associated adverse outcomes. Opportunities to enhance ATP performance exist, particularly for rapid monomorphic ventricular tachycardia (MVT). Intrinsic ATP (iATP) is the first closed-loop algorithm that designs and auto-adjusts ATP therapy in real-time.

Objective: Evaluate iATP performance in a large, real-world cohort.

Methods: This global, prospective, observational study enrolled patients with an iATP-enabled ICD or CRT-D device. The primary objective, to demonstrate iATP could effectively terminate >60% of MVT episodes in the fast VT (FVT) zone, was analyzed using generalized estimating equations (GEE) method. Additional analyses included overall effectiveness and rate of MVT acceleration resulting in shock. A post-hoc analysis used GEE models to compare iATP data to standard ATP from a retrospective cohort.

Results: In total, 1875 enrolled patients were followed a total of 3200 patient-years yielding 2575 iATP-treated MVT episodes. Of 265 iATP-treated episodes in the FVT zone (73 patients), the GEE-estimated success rate was 89.7% (95% confidence interval (CI): 83.6-93.7%), exceeding the primary objective. The GEE-estimated rate of iATP-associated MVT acceleration resulting in shock was 2.3%. Compared to standard ATP, iATP almost doubled the odds of VT termination (adjusted odds ratio [aOR]= 1.87, 95% CI: 1.32-2.66; P=0.0005) and halved the odds of acceleration resulting in shock (aOR= 0.43, 95% CI: 0.25-0.74; P=0.0026).

Conclusion: In routine practice, iATP was highly effective and safe across all VT rates. Although exploratory, iATP had overall superior termination rates and lower chance of acceleration resulting in shock compared to standard ATP.

Atrial electrical remodeling spans molecular, electrical, and structural alterations that shorten refractoriness, facilitate reentry, and ultimately create the atrial substrate underlying atrial fibrillation. These changes include ion-channel dysfunction, calcium-handling abnormalities, oxidative injury, and deranged proteostasis that are tightly intertwined with atrial fibrosis and cardiomyopathy. High-density mapping and advanced imaging now allow in-vivo staging of this substrate: left atrial low-voltage areas and functional conduction phenomena identify regions of fibrosis and conduction slowing that are associated with post-ablation recurrence, although the benefit of LVA-targeted substrate ablation remains uncertain. Building on this pathophysiological framework, this review integrates experimental and clinical evidence to guide decision-making in atrial fibrillation therapy, emphasizing early rhythm-control strategies and careful substrate characterization in sinus rhythm. Pulmonary vein isolation is presented as the cornerstone of ablation, while adjunctive substrate-oriented strategies - including low-voltage modification, hybrid surgical-catheter approaches, and vein-of-Marshall-based techniques - are discussed as investigational options for selected high-risk patients. Finally, the review contrasts PV-dependent and non-PV-dependent forms of atrial fibrillation and appraises emerging AI-guided electrogram interpretation within a mechanism-driven framework for personalized management of atrial electrical remodeling.

Background: Variants in the LMNA gene, responsible for laminopathies, are associated with severe cardiovascular outcomes, including arrhythmias and heart failure (HF). However, the differential prognostic impact of missense vs nonmissense variants remains unclear.

Objective: The primary end point of this systematic review and meta-analysis was to compare the cardiovascular outcome defined as combined malignant ventricular arrhythmias (MVAs) and HF among patients with missense vs nonmissense variants in the LMNA gene. Secondary outcomes included a comparison of MVAs and HF-related events analyzed separately.

Methods: A systematic search of PubMed, Ovid MEDLINE, and Cochrane Library was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Meta-analyses were performed using fixed or random effects models, depending on heterogeneity. PROSPERO identifier: CRD42024584721.

Results: 12 studies comprising 1818 participants were included. Of these, 969 had missense variants, and 849 had nonmissense variants. The nonmissense group showed a significantly higher rate of cardiovascular events (30.5% vs 21.3%; odds ratio [OR] 2.22; P < .001). MVAs were more frequent in nonmissense carriers (25.5% vs 18.9%; OR 2.37; P < .001). Although limited by the small number of studies (n = 5) and single-study bias, the incidence of HF-related severe events seemed similar between the groups (18.2% vs 23.9%; OR 0.956; P = .801).

Conclusion: Nonmissense LMNA variants are associated with worse cardiovascular outcomes, particularly arrhythmic events, whereas HF-related events seem comparable between nonmissense and missense variants.