Heart rhythm最新文献

{"title":"Innovative approach to conduction system pacing: Real-time ECG imaging guidance for precise left bundle branch area pacemaker lead placement","authors":"Ivan Eltsov MD, PhD ,&nbsp;Ingrid Overeinder MD ,&nbsp;Luigi Pannone MD, PhD ,&nbsp;Alvise Del Monte MD ,&nbsp;Neal Duong MSc ,&nbsp;Kayla Molina MSc ,&nbsp;Domenico Della Rocca MD, PhD ,&nbsp;Gezim Bala MD, PhD ,&nbsp;Giacomo Talevi MSc ,&nbsp;Erwin Stroker MD, PhD ,&nbsp;Juan Sieira MD, PhD ,&nbsp;Ali Gharaviri PhD ,&nbsp;Andrea Sarkozy MD, PhD ,&nbsp;Gian-Battista Chierchia MD, PhD ,&nbsp;Paul Iaizzo PhD, FHRS ,&nbsp;Mark La Meir MD, PhD ,&nbsp;Alexandre Almorad MD ,&nbsp;Carlo de Asmundis MD, PhD, FHRS","doi":"10.1016/j.hrthm.2025.11.048","DOIUrl":"10.1016/j.hrthm.2025.11.048","url":null,"abstract":"<div><h3>Background</h3><div>Left bundle branch area pacing is currently the procedure of choice for various indications including atrioventricular block and is considered a physiological modality of pacing compared with right ventricular apex pacing especially in young adults.</div></div><div><h3>Objectives</h3><div>This study aimed to increase the precision of left bundle branch area pacing (LBBAP) lead placement by developing a novel implantation technique using electrocardiographic imaging (ECGI).</div></div><div><h3>Methods</h3><div>This is a single-center prospective study. 10 consecutive patients who underwent an LBBAP device implantation under real-time ECGI guidance have been included in the study. Lead positioning was initially performed using fluoroscopy and a pacemaker analyzer only; then electrocardiographic (ECG) and ECGI analyses were performed in real time during the implantation at each lead position before and after fixation. ECG and ECGI parameters were measured as previously described. A directional activation map has been created for each attempt before lead fixation to ensure the final position. Correlation analysis between 12-lead ECG and ECGI values has been performed to analyze redundancy.</div></div><div><h3>Results</h3><div>LBBAP implantation was successful in all patients. ECGI has been shown to be a fast and visual way to assess interventricular activation at every stage of conduction system pacing lead implantation. Inferoposterior sheath positions are associated with long total ventricular activation time using ECGI and higher interventricular dyssynchrony than anterosuperior septal sheath positions. All procedures were performed with only 1 screwing attempt. Screwing depth is mostly characterized by total ventricular activation time and left ventricular activation time using ECGI reduction during the screwing process. Previously described discordance between classic ECG parameters and ECGI analysis was confirmed, and redundancy of certain parameters was confirmed. Correlation analysis confirmed the importance of ECGI measurement of right ventricular activation in general and total activation time and left ventricular activation time for patients with an intrinsic QRS duration of &gt;130 ms.</div></div><div><h3>Conclusion</h3><div>ECGI can bring significant value to conduction system device implantation. ECGI allows direct visualization of every procedural step, and its values confirm correct lead positioning and physiological ventricular activation. This might be very helpful in clinical practice by reducing the number of fixation attempts and proper activation assessment during the implantation, especially for patients with difficult cardiac and noncardiac anatomy.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages e453-e462"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simplified method of lead snaring to facilitate a tandem approach for long-dwelling transvenous lead extractions","authors":"Ato Howard MD,&nbsp;Krishna Kancharla MD,&nbsp;Konstantinos N. Aronis MD, PhD,&nbsp;Aditya Bhonsale MD, PhD,&nbsp;Andrew H. Voigt MD, FHRS,&nbsp;Mehak Dhande MD,&nbsp;Sandeep K. Jain MD, FHRS,&nbsp;Mark Estes MD, FHRS,&nbsp;Samir F. Saba MD, FHRS,&nbsp;Alaa A. Shalaby MD, MSc, FHRS","doi":"10.1016/j.hrthm.2025.12.030","DOIUrl":"10.1016/j.hrthm.2025.12.030","url":null,"abstract":"<div><h3>Background</h3><div>Increasingly, transvenous lead extractions (TLEs) have become more complex.</div></div><div><h3>Objective</h3><div>This study aimed to describe a novel technique for femoral snaring using commercially available equipment and study the application of this technique for a tandem approach in TLE cases with long-dwelling leads compared with conventional TLE.</div></div><div><h3>Methods</h3><div>We include 59 patients with long-dwelling transvenous leads who underwent powered sheath TLE with either upfront femoral snaring (n = 25) or conventional approach (n = 34). Our femoral snaring technique uses a grasping device within telescoped sheaths creating a rail for powered sheath advancement and lead dissection. Clinical and procedural data were obtained via manual electronic medical record review.</div></div><div><h3>Results</h3><div>Among our study cohort, 74.6% were men, the mean age was 66.1 ± 16.8 years, 57.6% were pacemaker dependent, 72.9% underwent TLE for infection, and the mean dwell time was 15.0 ± 4.7 years. The mean number of cardiac implantable electronic device leads and implantable cardioverter-defibrillator coils was 2.3 ± 1.0 and 1.8 ± 0.8, respectively. Compared with controls, intervention patients were older (72.5 ± 11.4 years vs 61.4 ± 18.6 years; <em>P</em> &lt; .01) and more likely to have ischemic cardiomyopathy (52.0% vs 29.4%; <em>P</em> = .04), lower left ventricular ejection fraction (41.8% ± 15.7% vs 49.8% ± 11.8%; <em>P</em> = .02), hypertension (84.0% vs 61.8%; <em>P</em> = .03), diabetes (76.0% vs 14.7%; <em>P</em> &lt; .01), and right-sided leads (28.0% vs 2.9%; <em>P</em> &lt; .01). No significant differences were observed in procedure or fluoroscopy times with a signal of lower complication rate among the intervention group. The only procedural mortality occurred in the control group.</div></div><div><h3>Conclusion</h3><div>We describe a novel upfront tandem TLE technique using commercially available items applied to long-dwelling leads. This technique was safe and effective compared with contemporary controls.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages e420-e427"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewer Thanks","authors":"","doi":"10.1016/S1547-5271(26)00071-8","DOIUrl":"10.1016/S1547-5271(26)00071-8","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages 507-511"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147413238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPV4 inhibition suppresses myocardial ischemia-reperfusion arrhythmia of mice by alleviating calcium handling abnormalities","authors":"Shuaitao Yang MD ,&nbsp;Jiu Pu MD ,&nbsp;Jinfang Yu MD ,&nbsp;Haixiong Wang MD, PhD, FHRS ,&nbsp;Yuwei Wu MD ,&nbsp;Yang Lu MD, PhD ,&nbsp;Ning Zhao MD, PhD ,&nbsp;Qiongfeng Wu MD, PhD ,&nbsp;Qian Dong MD, PhD ,&nbsp;Yimei Du MD, PhD","doi":"10.1016/j.hrthm.2025.04.006","DOIUrl":"10.1016/j.hrthm.2025.04.006","url":null,"abstract":"<div><h3>Background</h3><div><span>Transient receptor potential vanilloid 4 (TRPV4), a calcium (Ca</span>²⁺<span>) permeable channel, is upregulated during myocardial ischemia-reperfusion (IR). Although TRPV4 inhibition has cardioprotective effects, its impact on arrhythmogenesis remains unclear.</span></div></div><div><h3>Objective</h3><div><span>This study aimed to evaluate the antiarrhythmic effects of TRPV4 inhibition, using the TRPV4 antagonist GSK2193874 (GSK219) and TRPV4 knockout (TRPV4</span>^−/−<span>) mice, after IR.</span></div></div><div><h3>Methods</h3><div><span>Surface electrocardiogram and optical mapping recordings were performed during 15 minutes of global ischemia and 10 minutes of reperfusion in Langendorff perfused mouse hearts. Ca</span>²⁺<span><span> sparks were detected by confocal microscopy<span>, and protein expression was analyzed by </span></span>Western blot.</span></div></div><div><h3>Results</h3><div><span>GSK219 or TRPV4 deletion significantly decreased the incidence and duration of ventricular tachycardia during reperfusion. TRPV4 inhibition shortened Ca</span>²⁺<span> transient (CaT) recovery, suppressed CaT alternans, and decreased Ca</span>²⁺<span><span> leak without affecting IR-induced prolongation of action potential duration (APD) and APD alternations. Activation of TRPV4 by GSK101790A (GSK101) increased </span>arrhythmia susceptibility and Ca</span>²⁺ leak. Moreover, GSK101 prolonged CaT recovery and promoted CaT alternans, which were greatly avoided by pretreatment with Ca²⁺<span><span>/calmodulin-dependent protein kinase II (CaMKII) inhibitor. Interestingly, IR or GSK101 markedly increased the phosphorylation of </span>CaMKII<span><span>, ryanodine receptors, and </span>phospholamban, which was significantly blocked by TRPV4 inhibition.</span></span></div></div><div><h3>Conclusion</h3><div><span>TRPV4 inhibition exerts antiarrhythmic effects after IR by modulating CaMKII-dependent Ca</span>²⁺ handling abnormalities, reducing CaT alternans and Ca²⁺ leak, without affecting APD.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages 730-740"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure hospitalization from recurrent atrial fibrillation is uncommon after catheter ablation in patients with heart failure with reduced ejection fraction","authors":"Kenneth K. Cho MBBS, MPhil ,&nbsp;Sandeep Prabhu MBBS, PhD ,&nbsp;Louise Segan MBBS ,&nbsp;Jeremy B. William MBBS ,&nbsp;Rose F. Crowley MBBS ,&nbsp;Nicholas D’Elia MBBS ,&nbsp;David Chieng MBBS, PhD ,&nbsp;Hariharan Sugumar MBBS, PhD ,&nbsp;Liang-Han Ling MBBS, PhD ,&nbsp;Aleksandr Voskoboinik MBBS, PhD ,&nbsp;Joseph B. Morton MBBS, PhD ,&nbsp;Geoffrey Lee MBChD, PhD ,&nbsp;Alex J. McLellan MBBS, PhD ,&nbsp;Justin Lineham MD ,&nbsp;Matthew Morton MD ,&nbsp;Sonia Azzopardi RN ,&nbsp;Annie Curtin RN ,&nbsp;Michael W. Lim MBBS ,&nbsp;Youlin Koh MBBS ,&nbsp;Michael Wong MBBS, PhD ,&nbsp;Peter M. Kistler MBBS, PhD, FHRS","doi":"10.1016/j.hrthm.2025.06.004","DOIUrl":"10.1016/j.hrthm.2025.06.004","url":null,"abstract":"<div><h3>Background</h3><div>Heart failure with reduced ejection fraction (HFrEF) in the presence of atrial fibrillation (AF) is common, with concerns that AF recurrence will precipitate acute decompensation. However, the impact of AF recurrence after catheter ablation on heart failure is not well understood.</div></div><div><h3>Objective</h3><div>We sought to examine the clinical outcomes and hospitalization patterns in patients with AF HFrEF after catheter ablation.</div></div><div><h3>Methods</h3><div>This multicenter study reports the readmission outcomes for patients with AF and HFrEF (left ventricular ejection fraction [LVEF] ≤40%) after catheter ablation.</div></div><div><h3>Results</h3><div>A total of 231 patients (60.5 ± 11.1 years, 37 female patients, mean LVEF 30.7% ± 7.1%, persistent AF 87.9%) with AF and HFrEF underwent catheter ablation. At 3-year follow-up, recurrent AF occurred in 120 (51.9%) and complete left ventricular systolic recovery (LVEF ≥50%) in 125 patients (54%). There were 366 hospitalizations among 123 patients: 240 cardiac and 126 noncardiac. Arrhythmia-related hospitalizations occurred in 179: 151 recurrent atrial arrhythmia without heart failure, 4 AF with heart failure, 3 supraventricular tachycardia, and 21 ventricular arrhythmia. Other cardiac hospitalizations (61) included heart failure without AF recurrence (24), cardiac device insertions (24), ischemic heart disease (8), pericarditis (3), and cardiac valvular surgery (2). On univariable analysis, the absence of LVEF recovery after ablation (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.11–12.55; <em>P</em> = .03), persistent AF vs paroxysmal AF recurrence (OR, 1.76; 95% CI, 1.21–27.72; <em>P</em> = .03), ischemic cardiomyopathy (OR, 3.62; 95% CI, 1.16–11.30; <em>P</em> = .02), and furosemide use (OR, 4.96; 95% CI, 1.55–15.91; <em>P</em> &lt; .01) were associated with future heart failure hospitalization.</div></div><div><h3>Conclusion</h3><div>After catheter ablation, it is uncommon for patients with AF and HFrEF to present with recurrent AF <em>and</em> heart failure, but more commonly present with heart failure <em>without</em> AF or AF <em>without</em> heart failure.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages e384-e391"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden death and asymptomatic arrhythmia in chronic lymphocytic leukemia patients treated with ibrutinib","authors":"Emily Tomasulo DO ,&nbsp;Andy Itsara MD ,&nbsp;Mark Haigney MD, FHRS ,&nbsp;Douglas R. Rosing MD ,&nbsp;Inhye E. Ahn MD ,&nbsp;Cody Peer PhD ,&nbsp;Beth A. Kozel MD, PhD ,&nbsp;Teresa Luperchio PhD ,&nbsp;Grace Ge BS ,&nbsp;William D. Figg PharmD ,&nbsp;Adrian Wiestner MD, PhD ,&nbsp;Clare Sun MD","doi":"10.1016/j.hrthm.2025.10.014","DOIUrl":"10.1016/j.hrthm.2025.10.014","url":null,"abstract":"<div><h3>Background</h3><div>Ibrutinib (IBR) is a first-in-class Bruton’s tyrosine kinase inhibitor (BTKi) approved in multiple hematologic conditions for indefinite use until disease progression or toxicity. Hypertension and atrial fibrillation are well-recognized cardiac complications of BTKi; more recently, heart failure, additional arrhythmias, and sudden cardiac death (SCD) have been attributed to IBR. Next-generation covalent BTKi are also associated with cardiovascular complications, including SCD, albeit to a lesser degree.</div></div><div><h3>Objective</h3><div>The incidence and clinical features of patients experiencing SCD and asymptomatic arrhythmias on IBR remain ill defined. We aimed to characterize the incidence of SCD and asymptomatic arrhythmias on IBR.</div></div><div><h3>Methods</h3><div>We report (1) a retrospective cohort analysis of 131 patients with a median of 66.5 months on IBR using available cardiac testing, genetic sequencing, and autopsy review and (2) a cross-sectional cardiac analysis of 21 asymptomatic patients on IBR including ambulatory electrocardiogram, stress tests, and transthoracic echocardiograms.</div></div><div><h3>Results</h3><div>The incidence of SCD in patients on IBR (n = 5) was 801 per 100,000 patient-years, approximately 2–4× higher than the general population. All patients with SCD on IBR had at least 1 cardiac risk factor. Autopsies conducted in 3 of 5 patients with SCD did not reveal acute pathologic processes, but did demonstrate evolving cardiac pathology. Cardiovascular testing in asymptomatic patients on IBR revealed previously unknown clinically significant arrhythmias in 4 patients (19%), leading to precautionary IBR discontinuation in 2 patients.</div></div><div><h3>Conclusion</h3><div>IBR increases the risk of SCD among patients with cardiac risk factors. Stress and ambulatory electrocardiogram on IBR identified asymptomatic arrhythmias altering clinical management in 19% of patients. These data highlight the need for risk-mitigation strategies for patients starting or receiving IBR, possibly extending to other BTKis.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages 766-773"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of prolonged waiting list times for ablation of atrial fibrillation on arrhythmia recurrence after ablation","authors":"Jonathan P. Ariyaratnam MB BChir, PhD ,&nbsp;Gregory Horsfall MD ,&nbsp;Scott A. Gall MBBS ,&nbsp;Gavin S. Chu MB BChir, PhD ,&nbsp;Aruna V. Arujuna MBChB, MD(Res) ,&nbsp;Shajil Chalil MBBS","doi":"10.1016/j.hrthm.2025.10.057","DOIUrl":"10.1016/j.hrthm.2025.10.057","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages e492-e494"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and heart failure risk in atrial fibrillation: Prospective evidence from UK Biobank","authors":"Le Li MD ,&nbsp;Sheng Su MD ,&nbsp;Lingmin Wu MD ,&nbsp;Zhicheng Hu MD ,&nbsp;Limin Liu MD ,&nbsp;Likun Zhou MD ,&nbsp;Xi Peng MD ,&nbsp;Mengtong Xu MD ,&nbsp;Tao Zhang MD ,&nbsp;Yulong Xiong MD ,&nbsp;Zhenhao Zhang MD ,&nbsp;Lihui Zheng MD ,&nbsp;Ligang Ding MD ,&nbsp;Yan Yao MD, FHRS","doi":"10.1016/j.hrthm.2025.11.014","DOIUrl":"10.1016/j.hrthm.2025.11.014","url":null,"abstract":"<div><h3>Background</h3><div>Although atrial fibrillation (AF) raises heart failure (HF) risk and inflammation is associated with cardiovascular disease, the role of inflammation in linking AF to HF remains unclear.</div></div><div><h3>Objective</h3><div>This study aimed to assess whether systemic inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), elevates HF risk in patients with AF.</div></div><div><h3>Methods</h3><div>This prospective study included 32,502 AF participants from the UK Biobank without baseline HF, significant mitral valve disease, or inflammatory conditions. Hs-CRP was analyzed both as quartiles and using a clinical cutoff value of ≥2 mg/dL. The association with incident HF was evaluated using Cox models and Fine-Gray regression. Sensitivity analyses included sequential exclusion of comorbidities and early events, as well as propensity score matching.</div></div><div><h3>Results</h3><div>Over a median follow-up of 13.3 years, 6805 incident HF cases were documented. The cumulative incidence of HF increased significantly across hs-CRP quartiles, from 16.5% (1386 of 8419) in quartile 1 to 26.9% (2096 of 7786) in quartile 4 (log-rank <em>P</em> &lt; .001). In fully adjusted models, quartile 4 had 61% higher HF risk than quartile 1 (hazard ratio [HR] 1.61; 95% confidence interval [CI] 1.51–1.73). Elevated hs-CRP (≥2 mg/dL) (HR 1.39; 95% CI 1.33–1.46) and per-standard-deviation increase (HR 1.12; 95% CI 1.10–1.15) were consistently associated with higher HF risk. These findings remained robust across all sensitivity analyses, subgroup comparisons, propensity score matching cohorts, and competing risk models.</div></div><div><h3>Conclusion</h3><div>Elevated hs-CRP is an independent predictor of increased HF risk in patients with AF, supporting its potential role in improving HF risk stratification.</div></div>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages e339-e347"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First clinical experience using a pentaspline pulse field ablation catheter with integrated electroanatomic 3-dimensional mapping for pulmonary vein isolation","authors":"Gianfranco Mitacchione PhD, MD ,&nbsp;Claudio Tondo PhD, MD ,&nbsp;Antonio Dello Russo PhD, MD ,&nbsp;Maurizio Malacrida MSc ,&nbsp;Stefano Bianchi MD ,&nbsp;Saverio Iacopino MD ,&nbsp;Luca Rossi MD ,&nbsp;Gianmarco Arabia MD ,&nbsp;Marco Schiavone PhD, MD ,&nbsp;Francesco Solimene MD ,&nbsp;Michela Casella PhD, MD ,&nbsp;Gianluca Zingarini MD ,&nbsp;Maurizio Russo MD ,&nbsp;Mario Volpicelli MD ,&nbsp;Ruggero Maggio MD ,&nbsp;Vittoria Velcich MSc ,&nbsp;Raimondo Calvanese MD ,&nbsp;Roberto Rordorf MD ,&nbsp;Andrea Di Cori MD ,&nbsp;Fabrizio Tundo MD ,&nbsp;Antonio Curnis MD","doi":"10.1016/j.hrthm.2025.11.023","DOIUrl":"10.1016/j.hrthm.2025.11.023","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Pages e489-e491"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145540180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to— DNA methylation and the potential role of extracellular vesicles in epilepsy-associated atrial fibrillation","authors":"Zequn Zheng PhD ,&nbsp;Yanbin Chen MMSc ,&nbsp;Xuerui Tan MD, PhD","doi":"10.1016/j.hrthm.2025.11.051","DOIUrl":"10.1016/j.hrthm.2025.11.051","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"23 3","pages":"Page e508"},"PeriodicalIF":5.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}