Hormones and Behavior最新文献_第9页

Hormonal lockdown: How mole-rat societies enforce infertility in helpers 荷尔蒙锁定：鼹鼠社会如何强制帮助者不孕。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-01 DOI: 10.1016/j.yhbeh.2025.105836

A.K. Janse van Vuuren , T. Süess , Kyle Finn , N. Hagenah , A. Ganswindt , D.W. Hart , N.C. Bennett

Reproductive suppression is a defining feature of cooperative breeding, yet the hormonal mechanisms regulating infertility in non-breeding individuals remain poorly understood. This study examines associations between circulating prolactin (PRL) and faecal metabolites of androgens (fAM), glucocorticoids (fGCM), and progesterone (fPM) in relation to socially induced infertility in two closely related cooperatively breeding mole-rat subspecies: the highveld (Cryptomys hottentotus pretoriae) and Natal mole-rat (C. hottentotus natalensis). Our results reveal a fundamental dichotomy in reproductive suppression strategies. Highveld mole-rats exhibited seasonally elevated circulating PRL in non-breeders during the dry season, coinciding with reduced pituitary responsiveness to exogenous gonadotropin-releasing hormone (GnRH) and lower gonadal steroid metabolites. These associations are consistent with PRL involvement in physiological suppression of the hypothalamic-pituitary-gonadal (HPG) axis, but causality cannot currently be inferred. In stark contrast, Natal mole-rats showed relatively low and stable PRL levels across reproductive groups and seasons, with breeders exhibiting higher androgen and progesterone metabolites compared to non-breeders, a pattern consistent with behavioural suppression through incest avoidance, aggression or social dominance. These findings highlight the adaptive flexibility of cooperatively breeding systems and provide new insights into the hormonal architecture of reproductive suppression. Although the present findings do not establish causality, they delineate key hormonal and behavioural pathways that warrant future investigation.

生殖抑制是合作繁殖的一个决定性特征，然而调节非繁殖个体不育的激素机制仍然知之甚少。本研究在两个密切相关的合作繁殖的鼹鼠亚种：高原（Cryptomys hottentotus pretoriae）和出生鼹鼠（C. hottentotus natalensis）中，研究了循环催乳素（PRL）和雄激素（fAM）、糖皮质激素（fGCM）和孕酮（fPM）的粪便代谢产物与社会诱导不孕之间的关系。我们的研究结果揭示了生殖抑制策略的基本二分法。旱季时，高原鼹鼠的循环PRL呈季节性升高，这与垂体对外源性促性腺激素释放激素（GnRH）的反应性降低和性腺类固醇代谢物降低相一致。这些关联与PRL参与下丘脑-垂体-性腺（HPG）轴的生理抑制是一致的，但目前还不能推断出因果关系。与此形成鲜明对比的是，在繁殖组和繁殖季节，纳塔尔鼹鼠的PRL水平相对较低且稳定，繁殖组的雄性激素和孕激素代谢产物高于非繁殖组，这种模式与通过避免乱伦、攻击或社会支配来抑制行为相一致。这些发现突出了合作繁殖系统的适应性灵活性，并为生殖抑制的激素结构提供了新的见解。虽然目前的发现没有建立因果关系，但它们描绘了关键的激素和行为途径，值得未来的研究。

{"title":"Hormonal lockdown: How mole-rat societies enforce infertility in helpers","authors":"A.K. Janse van Vuuren , T. Süess , Kyle Finn , N. Hagenah , A. Ganswindt , D.W. Hart , N.C. Bennett","doi":"10.1016/j.yhbeh.2025.105836","DOIUrl":"10.1016/j.yhbeh.2025.105836","url":null,"abstract":"<div><div>Reproductive suppression is a defining feature of cooperative breeding, yet the hormonal mechanisms regulating infertility in non-breeding individuals remain poorly understood. This study examines associations between circulating prolactin (PRL) and faecal metabolites of androgens (fAM), glucocorticoids (fGCM), and progesterone (fPM) in relation to socially induced infertility in two closely related cooperatively breeding mole-rat subspecies: the highveld (<em>Cryptomys hottentotus pretoriae</em>) and Natal mole-rat (<em>C. hottentotus natalensis</em>). Our results reveal a fundamental dichotomy in reproductive suppression strategies. Highveld mole-rats exhibited seasonally elevated circulating PRL in non-breeders during the dry season, coinciding with reduced pituitary responsiveness to exogenous gonadotropin-releasing hormone (GnRH) and lower gonadal steroid metabolites. These associations are consistent with PRL involvement in physiological suppression of the hypothalamic-pituitary-gonadal (HPG) axis, but causality cannot currently be inferred. In stark contrast, Natal mole-rats showed relatively low and stable PRL levels across reproductive groups and seasons, with breeders exhibiting higher androgen and progesterone metabolites compared to non-breeders, a pattern consistent with behavioural suppression through incest avoidance, aggression or social dominance. These findings highlight the adaptive flexibility of cooperatively breeding systems and provide new insights into the hormonal architecture of reproductive suppression. Although the present findings do not establish causality, they delineate key hormonal and behavioural pathways that warrant future investigation.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"176 ","pages":"Article 105836"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tectal CRF receptors modulate the behavioral response of Xenopus laevis to live prey but not visual prey cues. 皮层CRF受体调节非洲爪蟾对活体猎物的行为反应，而不是视觉猎物线索。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI: 10.1016/j.yhbeh.2025.105801

Breanna N Harris, Christine M Prater, Ryann Lockwood, Allison Kennedy, M Ghufran Murtuza, James A Carr

Tradeoffs between feeding and defensive behaviors are critical for survival, but their physiological underpinnings are not well known. Here, we investigate how a satiety peptide, corticotropin-releasing factor (CRF), acts within a novel location, the visual system (the optic tectum, OT), to modulate multisensory prey detection and the microstructure of feeding behavior. The OT has CRF-producing interneurons and CRF receptors, threat exposure increases OT CRF concentrations, and that CRF acts on receptors in the OT to decrease feeding behavior. We hypothesized that CRF in the OT may impact visual, lateral line, and/or multiple sensory processing to alter feeding. We predicted that OT CRF decreases responses to 1) a purely visual prey cue and 2) a live, multisensory prey item. We microinjected one of four doses of CRF bilaterally into the tecta of newly metamorphosed Xenopus laevis. We then exposed frogs to visual prey cues and then to live, multi-sensory prey (worms). We repeated the behavioral assays after 72 h to determine if any effects were long-lasting. Overall, frogs robustly responded to live and visual prey cues. CRF did not alter behavioral responses to the visual prey cues but did decrease select prey-capture behaviors and increase select avoidance-like behaviors following exposure to live prey. Our results suggest visual processing is not the primary sensory modality impacted by tectal CRF. These data provide a novel (i.e., extrahypothalamic) location for satiety peptide action and link neuroendocrine responses to ecological context of feed/flee tradeoffs.

觅食和防御行为之间的权衡对生存至关重要，但其生理基础尚不清楚。在这里，我们研究了一种饱腹肽，促肾上腺皮质激素释放因子（CRF）如何在一个新的位置，视觉系统（视神经顶盖，OT）中起作用，以调节多感官猎物探测和摄食行为的微观结构。OT具有产生CRF的中间神经元和CRF受体，威胁暴露增加OT的CRF浓度，并且CRF作用于OT中的受体以减少摄食行为。我们假设外耳部的CRF可能影响视觉、侧线和/或多重感觉处理，从而改变进食。我们预测，OT CRF会降低对1)纯视觉猎物线索和2)活的、多感官猎物项目的反应。我们将四剂CRF中的一剂微注射到新变形的非洲爪蟾的双侧内侧。然后，我们让青蛙接触到视觉猎物线索，然后是活的、多感官的猎物（蠕虫）。我们在72小时后重复行为测试，以确定是否有任何影响是持久的。总的来说，青蛙对活生生的和视觉上的猎物线索反应强烈。CRF没有改变对视觉猎物线索的行为反应，但减少了选择捕获猎物的行为，增加了选择回避的行为。我们的研究结果表明，视觉处理并不是受颅顶CRF影响的主要感觉方式。这些数据为饱腹肽作用提供了一个新的（即下丘脑外）定位，并将神经内分泌反应与饲料/逃跑权衡的生态背景联系起来。

{"title":"Tectal CRF receptors modulate the behavioral response of Xenopus laevis to live prey but not visual prey cues.","authors":"Breanna N Harris, Christine M Prater, Ryann Lockwood, Allison Kennedy, M Ghufran Murtuza, James A Carr","doi":"10.1016/j.yhbeh.2025.105801","DOIUrl":"10.1016/j.yhbeh.2025.105801","url":null,"abstract":"<p><p>Tradeoffs between feeding and defensive behaviors are critical for survival, but their physiological underpinnings are not well known. Here, we investigate how a satiety peptide, corticotropin-releasing factor (CRF), acts within a novel location, the visual system (the optic tectum, OT), to modulate multisensory prey detection and the microstructure of feeding behavior. The OT has CRF-producing interneurons and CRF receptors, threat exposure increases OT CRF concentrations, and that CRF acts on receptors in the OT to decrease feeding behavior. We hypothesized that CRF in the OT may impact visual, lateral line, and/or multiple sensory processing to alter feeding. We predicted that OT CRF decreases responses to 1) a purely visual prey cue and 2) a live, multisensory prey item. We microinjected one of four doses of CRF bilaterally into the tecta of newly metamorphosed Xenopus laevis. We then exposed frogs to visual prey cues and then to live, multi-sensory prey (worms). We repeated the behavioral assays after 72 h to determine if any effects were long-lasting. Overall, frogs robustly responded to live and visual prey cues. CRF did not alter behavioral responses to the visual prey cues but did decrease select prey-capture behaviors and increase select avoidance-like behaviors following exposure to live prey. Our results suggest visual processing is not the primary sensory modality impacted by tectal CRF. These data provide a novel (i.e., extrahypothalamic) location for satiety peptide action and link neuroendocrine responses to ecological context of feed/flee tradeoffs.</p>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"105801"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy modulates responses to male odors in house mice. 怀孕调节家鼠对雄性气味的反应。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1016/j.yhbeh.2025.105802

Caitlin H Miller, Tess M Reichard, Jay Yang, Brandon Carlson-Clarke, Caleb C Vogt, Melissa R Warden, Michael J Sheehan

Pregnancy induces widespread physiological and behavioral changes, yet its impact on social decision-making remains poorly understood. Here, we show that reproductive status modulates female responses to male odors in house mice, revealing striking status-specific behavioral patterns. Estrous females displayed attraction to novel male odors, consistent with a motivation to mate. In contrast, pregnant females exhibited strong aversion - an anticipatory shift likely aimed at avoiding future infanticidal males. This status-dependent approach-avoidance response was recapitulated to the male urinary pheromone darcin, highlighting its robustness as a male signal. These findings suggest that reproductive status modulates odor-driven decision-making, balancing mating opportunities with offspring protection. This shift is likely mediated by hormonal fluctuations such as rising progesterone and estrogen, that act on neural circuits involved in olfaction, threat detection, and social motivation. Behavioral responses were further shaped by the richness and context of social odors, supporting combinatorial processing of urinary pheromones. This aligns with mechanisms such as stud odor imprinting and self-referential matching for inbreeding avoidance. Overall, our results point to anticipatory behavioral adaptations during pregnancy that prepare females for the challenges of motherhood.

怀孕引起广泛的生理和行为变化，但其对社会决策的影响仍然知之甚少。在这里，我们展示了生殖状态调节雌性对雄性气味的反应，揭示了惊人的状态特定行为模式。发情的雌性对雄性的新奇气味表现出吸引力，这与交配的动机是一致的。相比之下，怀孕的雌性表现出强烈的厌恶——一种预期的转变，可能是为了避免未来的杀婴雄性。这种状态依赖的方法-回避反应被概括为男性尿信息素darcin，突出了其作为男性信号的稳健性。这些发现表明，生殖状态调节气味驱动的决策，平衡交配机会和后代保护。这种转变可能是由激素波动介导的，比如黄体酮和雌激素的上升，它们作用于涉及嗅觉、威胁检测和社会动机的神经回路。社会气味的丰富性和背景进一步塑造了行为反应，支持尿信息素的组合处理。这与种马气味印记和自我参照匹配等机制一致，以避免近亲繁殖。总的来说，我们的研究结果表明，怀孕期间的预期行为适应使女性为母亲的挑战做好了准备。

{"title":"Pregnancy modulates responses to male odors in house mice.","authors":"Caitlin H Miller, Tess M Reichard, Jay Yang, Brandon Carlson-Clarke, Caleb C Vogt, Melissa R Warden, Michael J Sheehan","doi":"10.1016/j.yhbeh.2025.105802","DOIUrl":"10.1016/j.yhbeh.2025.105802","url":null,"abstract":"<p><p>Pregnancy induces widespread physiological and behavioral changes, yet its impact on social decision-making remains poorly understood. Here, we show that reproductive status modulates female responses to male odors in house mice, revealing striking status-specific behavioral patterns. Estrous females displayed attraction to novel male odors, consistent with a motivation to mate. In contrast, pregnant females exhibited strong aversion - an anticipatory shift likely aimed at avoiding future infanticidal males. This status-dependent approach-avoidance response was recapitulated to the male urinary pheromone darcin, highlighting its robustness as a male signal. These findings suggest that reproductive status modulates odor-driven decision-making, balancing mating opportunities with offspring protection. This shift is likely mediated by hormonal fluctuations such as rising progesterone and estrogen, that act on neural circuits involved in olfaction, threat detection, and social motivation. Behavioral responses were further shaped by the richness and context of social odors, supporting combinatorial processing of urinary pheromones. This aligns with mechanisms such as stud odor imprinting and self-referential matching for inbreeding avoidance. Overall, our results point to anticipatory behavioral adaptations during pregnancy that prepare females for the challenges of motherhood.</p>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"105802"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stranger-directed consolation-like behavior in mice in a test of social decision making 在一项社会决策测试中，老鼠在陌生人指导下的安慰行为。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-30 DOI: 10.1016/j.yhbeh.2025.105831

Sarah A. Blumenthal , Henry W. Kietzman , Karinne E. Cobb , Shannon L. Gourley

In the past decade, investigations into the neurobiology of empathy have been propelled by evidence that rodents are capable of more complex and nuanced social behaviors than previously believed. Several teams have reported that rodents will direct allogrooming and other consolation-like behaviors towards distressed conspecifics, including in situations in which consolation-like behavior was not the explicit focus of a given study. As a case in point, we unexpectedly found in a test of decision making incentivized by social experience that mice display consolation-like allogrooming towards distressed strangers. This observation was somewhat surprising because consolation-like behavior in rodents is often believed to be reserved for familiar conspecifics. Here in this brief report, we reveal that the allogrooming and close social proximity with a distressed stranger that we previously reported was accompanied by elevated sniffing and autogrooming in close proximity to the conspecific – a social contagion-like behavior. Also, these behaviors were not obviously attributable to general hyper-activity. We then describe the conditions in which this constellation of stranger-directed consolation-related behavior was observed, should this information support new research concerning stranger-directed consolation-like behavior.

在过去的十年里，有证据表明，啮齿动物能够比以前认为的更复杂、更微妙的社会行为，这推动了对移情神经生物学的研究。几个研究小组报告说，啮齿动物会对痛苦的同种动物进行同种梳理和其他类似安慰的行为，包括在类似安慰的行为不是特定研究的明确重点的情况下。作为一个恰当的例子，我们意外地发现，在一项由社会经验激励的决策测试中，老鼠对痛苦的陌生人表现出安慰性的修饰。这一观察结果有些令人惊讶，因为啮齿动物的安慰行为通常被认为是为熟悉的同类保留的。在这篇简短的报告中，我们揭示了我们之前报道的与一个痛苦的陌生人的异体梳理和近距离社交，伴随着更高的嗅探和近距离自我梳理——一种类似社会传染的行为。此外，这些行为不能明显归因于一般的过度活跃。然后，我们描述了观察到陌生人指导的安慰相关行为的条件，这些信息是否支持关于陌生人指导的安慰类行为的新研究。

{"title":"Stranger-directed consolation-like behavior in mice in a test of social decision making","authors":"Sarah A. Blumenthal , Henry W. Kietzman , Karinne E. Cobb , Shannon L. Gourley","doi":"10.1016/j.yhbeh.2025.105831","DOIUrl":"10.1016/j.yhbeh.2025.105831","url":null,"abstract":"<div><div>In the past decade, investigations into the neurobiology of empathy have been propelled by evidence that rodents are capable of more complex and nuanced social behaviors than previously believed. Several teams have reported that rodents will direct allogrooming and other consolation-like behaviors towards distressed conspecifics, including in situations in which consolation-like behavior was not the explicit focus of a given study. As a case in point, we unexpectedly found in a test of decision making incentivized by social experience that mice display consolation-like allogrooming towards distressed strangers. This observation was somewhat surprising because consolation-like behavior in rodents is often believed to be reserved for familiar conspecifics. Here in this brief report, we reveal that the allogrooming and close social proximity with a distressed stranger that we previously reported was accompanied by elevated sniffing and autogrooming in close proximity to the conspecific – a social contagion-like behavior. Also, these behaviors were not obviously attributable to general hyper-activity. We then describe the conditions in which this constellation of stranger-directed consolation-related behavior was observed, should this information support new research concerning stranger-directed consolation-like behavior.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"176 ","pages":"Article 105831"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining androgen and estrogen profiles during pubertal development in autistic and neurotypical girls 在自闭症和神经正常女孩的青春期发育过程中检查雄激素和雌激素谱。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-29 DOI: 10.1016/j.yhbeh.2025.105837

Blythe A. Corbett , Rachel Calvosa , Jaclyn Tamaroff , Rachael A. Muscatello , Trey McGonigle , Simon Vandekar

Background

Puberty is a normative albeit complex developmental period marked by significant changes in hormonal, physical, and socioemotional functioning. Research has theorized an important role for sex hormones in the etiology and profile of autism spectrum disorder (ASD), especially during developmental periods including puberty. Differences in pubertal onset in autistic compared to neurotypical girls have been reported. Aims examined female participants based on diagnostic (autistic, neurotypical) and hormonal expression (dehydroepiandrosterone (DHEA-S), estradiol, testosterone) in the context of development (puberty, age). Hypotheses included: Hyp 1: autistic compared to neurotypical girls would demonstrate earlier pubertal onset. Hyp 2: DHEA-S and estradiol would be higher in older, more physically mature girls. Hyp 3: Testosterone would be stable.

Methods

Participants included females between 6-to-12 years with ASD (N = 112) or typical development (TD, N = 96). Morning salivary samples were collected for hormone assays. Nonlinear least squares and ordinary linear regression models were used.

Results

Autistic girls did not show significant evidence of earlier pubertal onset in pubertal stage (p = 0.692). There were no observed diagnostic differences in hormone changes through the pubertal or age range (p = 0.8367, p = 0.0694, p = 0.6812, p = 0.8418, p = 0.7358, & p = 0.1438) sampled. All hormones showed significant changes with puberty and age (p < 0.001).

Conclusions

The study examined profiles of females based on diagnostic group and hormonal expression in the context of development. Although group differences were not observed in this cross-sectional study, hormonal differences may emerge as girls progress through puberty. It is vital to track and support autistic girls through this time of change and vulnerability.

背景：青春期是一个规范而复杂的发育时期，以激素、身体和社会情感功能的显著变化为特征。从理论上讲，性激素在自闭症谱系障碍（ASD）的病因和特征中起着重要作用，特别是在包括青春期在内的发育时期。孤独症女孩与神经正常女孩在青春期发病的差异已经有报道。目的是根据诊断（自闭症，神经正常）和激素表达（脱氢表雄酮（DHEA-S），雌二醇，睾酮）在发育（青春期，年龄）背景下对女性参与者进行检查。假设包括：假说1：与正常的女孩相比，自闭症女孩会表现出更早的青春期开始。Hyp 2: DHEA-S和雌二醇在年龄更大、身体更成熟的女孩中会更高。假说3：睾酮会很稳定。方法：参与者包括6- 12岁患有ASD （N = 112）或典型发育（TD, N = 96）的女性。早上采集唾液样本进行激素检测。采用非线性最小二乘法和普通线性回归模型。结果：孤独症女孩在发育期无显著性早熟迹象（p = 0.692）。在不同年龄段和不同年龄阶段，激素变化的诊断差异无统计学意义（p = 0.8367, p = 0.0694, p = 0.6812, p = 0.8418, p = 0.7358, p = 0.1438）。所有激素均随青春期和年龄发生显著变化(p)。结论：本研究基于诊断组和发育背景下激素表达检查了女性的概况。虽然在这项横断面研究中没有观察到组间差异，但随着女孩进入青春期，激素差异可能会出现。跟踪和支持自闭症女孩度过这一变化和脆弱的时期至关重要。

{"title":"Examining androgen and estrogen profiles during pubertal development in autistic and neurotypical girls","authors":"Blythe A. Corbett , Rachel Calvosa , Jaclyn Tamaroff , Rachael A. Muscatello , Trey McGonigle , Simon Vandekar","doi":"10.1016/j.yhbeh.2025.105837","DOIUrl":"10.1016/j.yhbeh.2025.105837","url":null,"abstract":"<div><h3>Background</h3><div>Puberty is a normative albeit complex developmental period marked by significant changes in hormonal, physical, and socioemotional functioning. Research has theorized an important role for sex hormones in the etiology and profile of autism spectrum disorder (ASD), especially during developmental periods including puberty. Differences in pubertal onset in autistic compared to neurotypical girls have been reported. Aims examined female participants based on diagnostic (autistic, neurotypical) and hormonal expression (dehydroepiandrosterone (DHEA-S), estradiol, testosterone) in the context of development (puberty, age). Hypotheses included: Hyp 1: autistic compared to neurotypical girls would demonstrate earlier pubertal onset. Hyp 2: DHEA-S and estradiol would be higher in older, more physically mature girls. Hyp 3: Testosterone would be stable.</div></div><div><h3>Methods</h3><div>Participants included females between 6-to-12 years with ASD (<em>N</em> = 112) or typical development (TD, <em>N</em> = 96). Morning salivary samples were collected for hormone assays. Nonlinear least squares and ordinary linear regression models were used.</div></div><div><h3>Results</h3><div>Autistic girls did not show significant evidence of earlier pubertal onset in pubertal stage (<em>p</em> = 0.692). There were no observed diagnostic differences in hormone changes through the pubertal or age range (<em>p</em> = 0.8367, <em>p</em> = 0.0694, <em>p</em> = 0.6812, <em>p</em> = 0.8418, <em>p</em> = 0.7358, & <em>p</em> = 0.1438) sampled. All hormones showed significant changes with puberty and age (<em>p</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>The study examined profiles of females based on diagnostic group and hormonal expression in the context of development. Although group differences were not observed in this cross-sectional study, hormonal differences may emerge as girls progress through puberty. It is vital to track and support autistic girls through this time of change and vulnerability.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"176 ","pages":"Article 105837"},"PeriodicalIF":2.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Within-litter variation in maternal care is a key contributor to individual differences in offspring behavior and monoamine neurochemistry in female Long–Evans rats 母性照顾的窝内差异是雌性Long-Evans大鼠后代行为和单胺神经化学个体差异的关键因素

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-25 DOI: 10.1016/j.yhbeh.2025.105821

Quintin A. Whitman , Amirreza Mirzaei , Samantha C. Lauby , Diptendu Chatterjee , Alison Fleming , Patrick O. McGowan

The care that a mother rat provides is essential for the ability of her pups to survive and thrive. Maternal care naturally varies between litters, including among animals with close genetic relatedness. There are also significant differences in behavior even among offspring reared together. Our lab and others have documented stable, naturally occurring individual differences in maternal care received by individual pups within the litter that persist throughout at least the first ten days of postnatal life. In this study, we hypothesized that within-litter variation in maternal care received constitutes a significant source of variation in offspring behavior and neurochemistry in Long-Evans rats. We analyzed measures related to maternal care behavior, offspring anxiety-like and social behaviors, and neurotransmitter levels in specific brain regions after the offspring became mothers themselves. For statistical modeling, we used the coefficient of variation (CV) to standardize and directly compare between- and within-litter variation across a range of behavioral and neurophysiological outcomes. Several variables analyzed showed greater within-litter CVs than between-litter CVs, especially for offspring behavior and levels of the monoamines dopamine, serotonin, and their primary metabolites DOPAC (3,4-dihydroxyphenylacetic acid) and 5-HIAA (5-hydroxyindoleacetic acid) in the nucleus accumbens, ventral tegmental area, medial preoptic area, hippocampus, and prefrontal cortex. Our findings suggest that within-litter variation in maternal care plays a prominent role in behavioral and physiological outcomes. This study provides a methodological advance by demonstrating that within-litter variability often exceeds between-litter variability across maternal, behavioral, and neurochemical domains, challenging a key assumption in experimental designs using littermate controls.

母鼠提供的照顾对幼鼠的生存和茁壮成长至关重要。母性照顾在不同胎仔之间自然是不同的，包括在遗传亲缘关系密切的动物之间。即使在共同抚养的后代中，行为也存在显著差异。我们的实验室和其他实验室已经记录了稳定的、自然发生的个体差异，这些差异至少在出生后的头十天内持续存在。在本研究中，我们假设，在龙伊文斯大鼠的后代行为和神经化学变异中，母性照顾的窝内变化是一个重要的来源。我们分析了与母亲照顾行为、后代焦虑和社交行为以及后代成为母亲后特定大脑区域的神经递质水平相关的测量。对于统计建模，我们使用变异系数（CV）来标准化和直接比较一系列行为和神经生理结果的凋落物之间和凋落物内的变异。分析的几个变量表明，窝内CVs大于窝间CVs，特别是后代行为和单胺类多巴胺、血清素及其主要代谢物DOPAC（3,4-二羟基苯基乙酸）和5-HIAA（5-羟基吲哚乙酸）在伏隔核、腹侧被盖区、内侧视前区、海马和前额皮质中的水平。我们的研究结果表明，产妇护理的窝内变化在行为和生理结果中起着重要作用。本研究提供了一个方法上的进步，通过证明在母系、行为和神经化学领域，窝内变异性往往超过窝间变异性，挑战了使用窝友控制的实验设计中的一个关键假设。

{"title":"Within-litter variation in maternal care is a key contributor to individual differences in offspring behavior and monoamine neurochemistry in female Long–Evans rats","authors":"Quintin A. Whitman , Amirreza Mirzaei , Samantha C. Lauby , Diptendu Chatterjee , Alison Fleming , Patrick O. McGowan","doi":"10.1016/j.yhbeh.2025.105821","DOIUrl":"10.1016/j.yhbeh.2025.105821","url":null,"abstract":"<div><div>The care that a mother rat provides is essential for the ability of her pups to survive and thrive. Maternal care naturally varies between litters, including among animals with close genetic relatedness. There are also significant differences in behavior even among offspring reared together. Our lab and others have documented stable, naturally occurring individual differences in maternal care received by individual pups within the litter that persist throughout at least the first ten days of postnatal life. In this study, we hypothesized that within-litter variation in maternal care received constitutes a significant source of variation in offspring behavior and neurochemistry in Long-Evans rats. We analyzed measures related to maternal care behavior, offspring anxiety-like and social behaviors, and neurotransmitter levels in specific brain regions after the offspring became mothers themselves. For statistical modeling, we used the coefficient of variation (CV) to standardize and directly compare between- and within-litter variation across a range of behavioral and neurophysiological outcomes. Several variables analyzed showed greater within-litter CVs than between-litter CVs, especially for offspring behavior and levels of the monoamines dopamine, serotonin, and their primary metabolites DOPAC (3,4-dihydroxyphenylacetic acid) and 5-HIAA (5-hydroxyindoleacetic acid) in the nucleus accumbens, ventral tegmental area, medial preoptic area, hippocampus, and prefrontal cortex. Our findings suggest that within-litter variation in maternal care plays a prominent role in behavioral and physiological outcomes. This study provides a methodological advance by demonstrating that within-litter variability often exceeds between-litter variability across maternal, behavioral, and neurochemical domains, challenging a key assumption in experimental designs using littermate controls.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"176 ","pages":"Article 105821"},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal contraceptives modulate resilience to psychiatric and neurodegenerative disease 激素避孕药调节对精神和神经退行性疾病的恢复力

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-22 DOI: 10.1016/j.yhbeh.2025.105823

Kristen M. Schuh, Leah M. Conrad, Natalie C. Tronson

Hormonal contraceptives (HCs) are one of the most widely used classes of drug worldwide and are a critical part of women's health. Beyond their primary use for birth control, HCs exert many health benefits, including treatment of menstrual-related symptoms and reduced risk of certain types of cancers. Here, we focus on the role of HCs in promoting resilience to depression and Alzheimer's disease. Although risks for depression with HC use have been widely stated, HCs only increase risk for up to 10 % of users, and conversely improve mood and protect against depression for many others. Emerging evidence also suggests that HC use protects against age-related cognitive decline and Alzheimer's disease, even decades after HC use. We propose that these effects are due to modulatory effects of HCs on stress-related signaling and neuroimmune function. In this paper, we discuss how HCs interact with stress responsivity, neuroimmune signaling, and other individual differences to promote resilience or susceptibility to psychiatric and neurological disorders.

激素避孕药是世界上使用最广泛的药物之一，是妇女健康的重要组成部分。除了主要用于节育之外，hc还具有许多健康益处，包括治疗月经相关症状和降低某些类型癌症的风险。在这里，我们关注hc在促进抑郁症和阿尔茨海默病的恢复能力中的作用。虽然使用大麻有抑郁症的风险已经被广泛指出，但大麻只增加了高达10%的使用者的风险，相反，对许多其他人来说，大麻可以改善情绪，防止抑郁。新出现的证据还表明，使用HC可以防止与年龄相关的认知能力下降和阿尔茨海默病，即使在使用HC几十年后也是如此。我们认为这些影响是由于hc对应激相关信号和神经免疫功能的调节作用。在本文中，我们讨论了hc如何与应激反应、神经免疫信号和其他个体差异相互作用，以促进对精神和神经疾病的恢复力或易感性。

引用次数: 0

Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking 中枢甲状腺激素受体- β：对酒精的敏感性和调节饮酒的作用。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-18 DOI: 10.1016/j.yhbeh.2025.105822

Michael C. Johnson , Michelle A. Nipper , Kelly M. Abshire , Jessica E. Rehmann , Jonathan A. Zweig , Theresa N. Vu , Mandee A. Bell , Tapasree Banerji , Thomas S. Scanlan , Andrey E. Ryabinin , Deena M. Walker

Clinical and preclinical evidence indicate that both peripheral and central elements of the hypothalamic-pituitary-thyroid (HPT) axis are dysregulated in alcohol use disorder, and that thyroid hormone system dysregulation is associated alcohol craving and co-morbid mood and depression-related disorders. Yet, no study has investigated if central nervous system (CNS) thyroid hormone receptors, primary targets of thyroid hormone and major regulators of the HPT axis are involved in alcohol consumption. We utilized a 24-h access two-bottle choice (2BC) voluntary ethanol (EtOH) drinking paradigm to assess if the expression of CNS thyroid hormone receptors is sensitive to voluntary alcohol consumption in C57BL/6 J mice. We found that thyroid hormone receptor-beta (Thrb/THRβ) mRNA expression was significantly reduced in the paraventricular nucleus of the hypothalamus of EtOH drinking mice compared to water controls. In addition, EtOH drinking mice exhibited peripheral elevation of serum triiodothyronine. Next, we utilized the CNS selective THRβ agonist, Sob-AM2, to determine if central activation of THRβ would influence voluntary alcohol drinking in mice in the same EtOH 2BC drinking paradigm. We found that repeated treatment with Sob-AM2 significantly reduced daily EtOH intake and preference, while in conjunction increasing water intake. In summary, we found that hypothalamic Thrb expression is sensitive to voluntary alcohol drinking, and that CNS THRβ activity regulates alcohol consumption in mice. Taken together, our results highlight an important role of central thyroid hormone receptor signalling in alcohol drinking and indicate therapeutic potential of CNS selective thyromimetics in treatment of alcohol use disorder.

临床和临床前证据表明，下丘脑-垂体-甲状腺（HPT）轴的外周和中枢元素在酒精使用障碍中都是失调的，甲状腺激素系统失调与酒精渴望和共病的情绪和抑郁相关障碍有关。然而，没有研究调查中枢神经系统（CNS）甲状腺激素受体、甲状腺激素的主要靶点和HPT轴的主要调节因子是否与饮酒有关。我们利用24小时进入两瓶选择（2BC）自愿饮酒（EtOH）范式来评估C57BL/6 J小鼠CNS甲状腺激素受体的表达是否对自愿饮酒敏感。我们发现，与水对照组相比，饮用EtOH小鼠下丘脑室旁核中甲状腺激素受体- β (Thrb/THRβ) mRNA表达显著降低。此外，饮用EtOH小鼠外周血血清三碘甲状腺原氨酸升高。接下来，我们利用中枢神经系统选择性THRβ激动剂Sob-AM2来确定在相同的EtOH 2BC饮酒模式下，中枢激活THRβ是否会影响小鼠的自愿饮酒。我们发现反复使用Sob-AM2显著降低每日EtOH摄入量和偏好，同时增加水摄入量。总之，我们发现下丘脑Thrb表达对自愿饮酒敏感，中枢神经系统THRβ活性调节小鼠的酒精消耗。综上所述，我们的研究结果强调了中枢甲状腺激素受体信号在饮酒中的重要作用，并表明中枢神经系统选择性拟甲状腺药物治疗酒精使用障碍的治疗潜力。

{"title":"Central thyroid hormone receptor-beta: Sensitivity to alcohol and a role in regulating alcohol drinking","authors":"Michael C. Johnson , Michelle A. Nipper , Kelly M. Abshire , Jessica E. Rehmann , Jonathan A. Zweig , Theresa N. Vu , Mandee A. Bell , Tapasree Banerji , Thomas S. Scanlan , Andrey E. Ryabinin , Deena M. Walker","doi":"10.1016/j.yhbeh.2025.105822","DOIUrl":"10.1016/j.yhbeh.2025.105822","url":null,"abstract":"<div><div>Clinical and preclinical evidence indicate that both peripheral and central elements of the hypothalamic-pituitary-thyroid (HPT) axis are dysregulated in alcohol use disorder, and that thyroid hormone system dysregulation is associated alcohol craving and co-morbid mood and depression-related disorders. Yet, no study has investigated if central nervous system (CNS) thyroid hormone receptors, primary targets of thyroid hormone and major regulators of the HPT axis are involved in alcohol consumption. We utilized a 24-h access two-bottle choice (2BC) voluntary ethanol (EtOH) drinking paradigm to assess if the expression of CNS thyroid hormone receptors is sensitive to voluntary alcohol consumption in C57BL/6 J mice. We found that thyroid hormone receptor-beta (<em>Thrb</em>/THRβ) mRNA expression was significantly reduced in the paraventricular nucleus of the hypothalamus of EtOH drinking mice compared to water controls. In addition, EtOH drinking mice exhibited peripheral elevation of serum triiodothyronine. Next, we utilized the CNS selective THRβ agonist, Sob-AM2, to determine if central activation of THRβ would influence voluntary alcohol drinking in mice in the same EtOH 2BC drinking paradigm. We found that repeated treatment with Sob-AM2 significantly reduced daily EtOH intake and preference, while in conjunction increasing water intake. In summary, we found that hypothalamic <em>Thrb</em> expression is sensitive to voluntary alcohol drinking, and that CNS THRβ activity regulates alcohol consumption in mice. Taken together, our results highlight an important role of central thyroid hormone receptor signalling in alcohol drinking and indicate therapeutic potential of CNS selective thyromimetics in treatment of alcohol use disorder.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"176 ","pages":"Article 105822"},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and experimental study of micro/nanoplastic-induced endocrine disruption in rodents: Potential links to autism spectrum disorder 微/纳米塑料诱导的啮齿动物内分泌干扰的系统综述和实验研究：与自闭症谱系障碍的潜在联系

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-15 DOI: 10.1016/j.yhbeh.2025.105818

Lucas F. Fowler , T. Nadine Burry , Alexandre S. Maekawa , Lindsay S. Cahill

Recent research shows that microplastic (diameter < 5 mm) and nanoplastic (diameter < 1 μm) exposures can have endocrine-disrupting effects and lead to autism spectrum disorder (ASD)-like behaviours in rodent models. We combine both a (i) systematic literature review and (ii) experimental study to synthesize the potential mechanisms underlying the link between micro−/nanoplastic (MNP) exposure and ASD, focusing on endocrine disruption and articles utilizing rodent models. First, we identify and discuss trends in the literature, outline research gaps, and suggest future directions. Most articles measured gonadal hormones in male adult rodents and consistently reported decreased testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with MNP exposure. Females were understudied, with no trends emerging in exposure-induced hormone disruption. Second, we present experimental data demonstrating direct effects of maternal polystyrene NP exposure on neuroendocrine systems and inflammatory markers in the fetal brain. Cytokines, interleukin-2 (IL-2) and interleukin-6 (IL-6), and triiodothyronine (T3) were significantly altered in the fetal brain following prenatal exposure to NPs, and thyroxine (T4) and T were significantly suppressed in female NP-exposed fetuses but not in males. Together, these findings demonstrate that MNP exposure during adulthood and early development affect multiple endocrine systems, including those implicated in autism spectrum disorder, in a sex-dependent manner. We synthesize how such results are important to motivate exposure studies in animals and humans and future regulatory guidelines on MNPs.

最近的研究表明，在啮齿动物模型中，微塑料（直径5毫米）和纳米塑料（直径1 μm）暴露会产生内分泌干扰效应，并导致自闭症谱系障碍（ASD）样行为。我们结合了(i)系统的文献综述和（ii）实验研究，综合了微/纳米塑料（MNP）暴露与ASD之间联系的潜在机制，重点是内分泌干扰和利用啮齿动物模型的文章。首先，我们识别和讨论文献中的趋势，概述研究差距，并建议未来的方向。大多数文章测量了雄性成年啮齿动物的性腺激素，并一致报告了MNP暴露后睾酮(T)、黄体生成素（LH）和卵泡刺激素（FSH）的下降。对女性进行了充分的研究，没有发现暴露引起的激素紊乱的趋势。其次，我们提供的实验数据表明母体聚苯乙烯NP暴露对胎儿大脑神经内分泌系统和炎症标志物的直接影响。产前暴露于np后，胎儿脑内细胞因子、白细胞介素-2 （IL-2）、白细胞介素-6 （IL-6）和三碘甲状腺原氨酸（T3）显著改变，女性暴露于np的胎儿甲状腺素（T4）和T显著抑制，而男性暴露于np的胎儿则无显著抑制。总之，这些发现表明，在成年期和发育早期接触MNP会以性别依赖的方式影响多种内分泌系统，包括与自闭症谱系障碍有关的内分泌系统。我们综合了这些结果对激励动物和人类暴露研究以及未来MNPs监管指南的重要性。

{"title":"A systematic review and experimental study of micro/nanoplastic-induced endocrine disruption in rodents: Potential links to autism spectrum disorder","authors":"Lucas F. Fowler , T. Nadine Burry , Alexandre S. Maekawa , Lindsay S. Cahill","doi":"10.1016/j.yhbeh.2025.105818","DOIUrl":"10.1016/j.yhbeh.2025.105818","url":null,"abstract":"<div><div>Recent research shows that microplastic (diameter < 5 mm) and nanoplastic (diameter < 1 μm) exposures can have endocrine-disrupting effects and lead to autism spectrum disorder (ASD)-like behaviours in rodent models. We combine both a (i) systematic literature review and (ii) experimental study to synthesize the potential mechanisms underlying the link between micro−/nanoplastic (MNP) exposure and ASD, focusing on endocrine disruption and articles utilizing rodent models. First, we identify and discuss trends in the literature, outline research gaps, and suggest future directions. Most articles measured gonadal hormones in male adult rodents and consistently reported decreased testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) with MNP exposure. Females were understudied, with no trends emerging in exposure-induced hormone disruption. Second, we present experimental data demonstrating direct effects of maternal polystyrene NP exposure on neuroendocrine systems and inflammatory markers in the fetal brain. Cytokines, interleukin-2 (IL-2) and interleukin-6 (IL-6), and triiodothyronine (T3) were significantly altered in the fetal brain following prenatal exposure to NPs, and thyroxine (T4) and T were significantly suppressed in female NP-exposed fetuses but not in males. Together, these findings demonstrate that MNP exposure during adulthood and early development affect multiple endocrine systems, including those implicated in autism spectrum disorder, in a sex-dependent manner. We synthesize how such results are important to motivate exposure studies in animals and humans and future regulatory guidelines on MNPs.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105818"},"PeriodicalIF":2.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans 人际感觉运动同步中的催产素动力学：人类对照实验

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-09-13 DOI: 10.1016/j.yhbeh.2025.105817

Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina

Interpersonal sensorimotor synchronisation is the coordination of movement between individuals that underlies successful interpersonal communication. Previous research has indicated the potential involvement of oxytocin (OXT) in the process of synchronisation.

We conducted 2 randomised controlled experiments to test the effect of synchronisation on salivary OXT concentrations. In Experiment 1, 90 volunteers (65 women) performed either synchronous or asynchronous a 5-min hand gesture task with an unfamiliar partner. In Experiment 2, 67 familiar dyads of volunteers (47 female dyads) performed the same task. Salivary OXT concentrations were measured before and after the gesture task (Experiment 1) or before, after and 10 min after the gesture task (Experiment 2). Saliva samples were analysed using the ELISA method to estimate OXT concentrations.

In Experiment 1, we found no significant differences between salivary OXT levels at baseline and after the 5-min task in either synchronous or asynchronous conditions. We also found no evidence for increased liking of a stranger after sensorimotor synchrony. In Experiment 2, the asynchronous condition led to a decrease in OXT levels over time, whereas synchronous interactions led to stable OXT levels over time. The effect of condition on OXT was not moderated by closeness or attachment style. The results are discussed in relation to research methodology used to study interpersonal synchrony.

人际感觉运动同步是个体之间运动的协调，是成功人际沟通的基础。先前的研究表明，催产素（OXT）可能参与了同步过程。我们进行了2个随机对照实验来测试同步对唾液OXT浓度的影响。在实验1中，90名志愿者（65名女性）与一个不熟悉的伙伴一起进行了5分钟的同步或非同步手势任务。在实验2中，67对熟悉的志愿者（47对女性）执行同样的任务。在手势任务之前和之后（实验1）或手势任务之前，之后和之后10分钟（实验2）测量唾液OXT浓度。使用ELISA法分析唾液样本以估计OXT浓度。在实验1中，我们发现在同步或异步条件下，基线和5分钟任务后的唾液OXT水平没有显著差异。我们也没有发现在感觉运动同步后对陌生人的好感会增加的证据。在实验2中，异步条件导致OXT水平随着时间的推移而下降，而同步交互导致OXT水平随着时间的推移而稳定。亲密程度和依恋类型不影响条件对应激反应的影响。研究结果与研究人际同步性的研究方法有关。

{"title":"Oxytocin dynamics in interpersonal sensorimotor synchrony: Controlled experiments in humans","authors":"Elina Tsigeman , Larisa Mararitsa , Yana Gorina , Ailar Avliyakulyeva , Ekaterina Kindyakova , Olessia Koltsova , Olga Lopatina","doi":"10.1016/j.yhbeh.2025.105817","DOIUrl":"10.1016/j.yhbeh.2025.105817","url":null,"abstract":"<div><div>Interpersonal sensorimotor synchronisation is the coordination of movement between individuals that underlies successful interpersonal communication. Previous research has indicated the potential involvement of oxytocin (OXT) in the process of synchronisation.</div><div>We conducted 2 randomised controlled experiments to test the effect of synchronisation on salivary OXT concentrations. In Experiment 1, 90 volunteers (65 women) performed either synchronous or asynchronous a 5-min hand gesture task with an unfamiliar partner. In Experiment 2, 67 familiar dyads of volunteers (47 female dyads) performed the same task. Salivary OXT concentrations were measured before and after the gesture task (Experiment 1) or before, after and 10 min after the gesture task (Experiment 2). Saliva samples were analysed using the ELISA method to estimate OXT concentrations.</div><div>In Experiment 1, we found no significant differences between salivary OXT levels at baseline and after the 5-min task in either synchronous or asynchronous conditions. We also found no evidence for increased liking of a stranger after sensorimotor synchrony. In Experiment 2, the asynchronous condition led to a decrease in OXT levels over time, whereas synchronous interactions led to stable OXT levels over time. The effect of condition on OXT was not moderated by closeness or attachment style. The results are discussed in relation to research methodology used to study interpersonal synchrony.</div></div>","PeriodicalId":13001,"journal":{"name":"Hormones and Behavior","volume":"175 ","pages":"Article 105817"},"PeriodicalIF":2.4,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0