Hormones and Behavior最新文献_第8页

Editorial: The most common mistake involving the use of correlations 社论：最常见的错误涉及相关性的使用。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-11-01 DOI: 10.1016/j.yhbeh.2025.105848

Cheryl M. McCormick , Justin M. Carré

引用次数: 0

Glucocorticoid correlation between barn owl (Tyto alba) breeding partners and its association with reproductive success 仓鸮（Tyto alba）交配伙伴间糖皮质激素的相关性及其与繁殖成功率的关系。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-22 DOI: 10.1016/j.yhbeh.2025.105842

Paul Béziers , Lukas Jenni , Alexandre Roulin , Bettina Almasi

In biparental species, reproductive success is influenced by the quality of the parents, the care each provides, environmental factors, and the cooperation between parents in sharing reproductive tasks. Hormones like corticosterone, which modulate physiological and behavioural functions associated with reproductive success, likely play a critical role in reproductive success through hormonal compatibility between breeding partners. Here, we investigate how similarity or dissimilarity in corticosterone levels between barn owl (Tyto alba) breeding partners are related to reproductive success. Using data from 2004 to 2018, we analyzed baseline and stress-induced corticosterone to explore correlations between partners' corticosterone levels and their association with key fitness parameters including clutch size, offspring number, and rearing success. We found that while partners' corticosterone levels do not predict clutch size, they are a significant predictor of offspring number and rearing success. Pairs with dissimilar baseline and stress-induced corticosterone produced more fledglings than pairs with similar corticosterone levels. To evaluate the potential advantage or disadvantage of growing up in large broods, we further examined the effect of brood size on offspring quality and survival. Nestlings from smaller broods had better body condition than those from larger broods, and individuals with better condition were more likely to survive their first year. These findings suggest that barn owl reproductive success is influenced by the combined corticosterone profiles of both parents and indicate a potential trade-off between offspring quantity and quality. This study highlights the importance of considering both parents' hormonal profiles when evaluating corticosterone's role in reproduction among biparental species.

在双亲本物种中，繁殖成功受亲本的质量、各自提供的照顾、环境因素以及亲本之间在分担繁殖任务方面的合作的影响。激素，如皮质酮，调节与繁殖成功相关的生理和行为功能，可能通过繁殖伴侣之间的激素兼容性在繁殖成功中发挥关键作用。在这里，我们研究了仓鸮（Tyto alba）繁殖伴侣之间皮质酮水平的相似性或差异性如何与繁殖成功相关。利用2004年至2018年的数据，我们分析了基线和应激诱导的皮质酮水平，以探索伴侣皮质酮水平与关键适应度参数（包括产仔数量、后代数量和饲养成功率）之间的相关性。我们发现，虽然伴侣的皮质酮水平不能预测窝卵数量，但它们是后代数量和饲养成功的重要预测因素。基线和应激诱导的皮质酮水平不同的配对比皮质酮水平相似的配对产生更多的雏鸟。为了评估在大种群中生长的潜在优势或劣势，我们进一步研究了种群数量对后代质量和存活率的影响。小窝的雏鸟身体状况比大窝的雏鸟好，身体状况好的雏鸟更有可能在第一年存活下来。这些发现表明，仓鸮的繁殖成功受到父母双方皮质酮组合的影响，并表明后代数量和质量之间存在潜在的权衡关系。这项研究强调了在评估皮质酮在双亲本物种繁殖中的作用时，考虑双亲激素谱的重要性。

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引用次数: 0

Emotion recognition largely unaffected by combined oral contraceptive transitions or their androgenicity 情绪识别很大程度上不受联合口服避孕药过渡或其雄激素性的影响

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-20 DOI: 10.1016/j.yhbeh.2025.105843

Ann-Christin S. Kimmig , Lieve Thecla van Egmond , Birgit Derntl

Oral contraceptive (OC) intake has been linked to reduced emotion recognition, particularly for negative emotions, though cross-sectional findings are inconclusive. Differences in the androgenicity of OC formulations may partly explain these inconsistencies. This study examined the association of OC initiation or discontinuation on facial emotion recognition in women.

A total of 133 healthy young women completed the Vienna Emotion Recognition Test (VERT-K), which measures accuracy and response time of recognition of basic emotional expressions. Most participants (n = 115) completed the test twice and five groups were analyzed based on hormonal states: early follicular, peri-ovulatory, and active OC intake (control groups measured during the same hormonal phase twice), as well as OC discontinuation and initiation (before and after OC status transition).

Generalized linear mixed models revealed no significant changes in emotion recognition linked to OC initiation or discontinuation. Women in the early follicular phase and those discontinuing OCs were less accurate in recognizing neutral expressions compared to continuous OC users. Cross-sectional analysis showed no significant differences in emotion recognition between androgenic and antiandrogenic OC users. Exploratory correlation analyses suggest that changes in synthetic hormone levels may relate to emotion recognition performance, particularly improved anger recognition following OC discontinuation.

This first repeated-session study investigating OC status transitions could not replicate cross-sectional findings of impaired emotion recognition with OC use. However, given the importance of emotion recognition for social functioning and mental health, better powered longitudinal studies are essential to clarify mixed results and further investigate the potential associations between OCs and emotional processing.

口服避孕药（OC）的摄入与情绪识别能力下降有关，尤其是对负面情绪的识别，尽管横断面研究结果尚无定论。在雄激素性的OC配方的差异可能部分解释这些不一致。本研究考察了女性面部情绪识别开始或停止的关系。共有133名健康的年轻女性完成了维也纳情绪识别测试（VERT-K），该测试测量了识别基本情绪表达的准确性和反应时间。大多数参与者（n = 115）完成了两次测试，并根据激素状态对五组进行了分析：卵泡早期、排卵期和活性OC摄入（对照组在同一激素阶段测量两次），以及OC停止和开始（OC状态转换前后）。广义线性混合模型显示，与OC开始或停止相关的情绪识别没有显着变化。处于卵泡早期和停止使用卵泡激素的女性在识别中性表达方面的准确性低于持续使用卵泡激素的女性。横断面分析显示，雄激素和抗雄激素OC使用者在情绪识别方面没有显著差异。探索性相关分析表明，合成激素水平的变化可能与情绪识别表现有关，特别是在停用OC后，愤怒识别能力的提高。这是第一个调查OC状态转变的重复研究，不能重复使用OC时情绪识别受损的横断面研究结果。然而，鉴于情绪识别对社会功能和心理健康的重要性，更好的纵向研究对于澄清混合结果和进一步调查强迫症和情绪处理之间的潜在联系至关重要。

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引用次数: 0

Juvenile hormone and maternal egg care in the European earwig (part II): Precocene exposure reduces post-oviposition egg care behaviours 欧洲蠼螋的幼崽激素和母卵护理（第二部分）：早熟暴露减少产卵后的卵护理行为。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-15 DOI: 10.1016/j.yhbeh.2025.105839

Laura Pasquier, Violette Wallart, Louis Audebert, Séverine Devers, Joël Meunier , Charlotte Lécureuil

Parental care is a critical behaviour that enhances offspring survival and development across the animal kingdom. In insects, several studies have suggested that juvenile hormone (JH), a key regulator of their development and reproduction, also plays an important role in the regulation of parental care. However, recent findings in the European earwig Forficula auricularia challenge this view. In this study, we experimentally manipulated JH levels in 496 post-oviposition earwig females by exposing them to JHIII, two JH agonists (Methoprene, Pyriproxyfen), or a JH-production inhibitor (Precocene I). We then quantified the effects of these treatments on three key maternal care behaviours: egg gathering, egg guarding, and egg grooming. Consistent with a positive role of JH in promoting maternal care, we found that inhibiting JH synthesis via Precocene I led to a reduction in all three forms of maternal care. In contrast, supplementation with JHIII or exposure to JH agonists had no detectable effect on these care behaviours. The observed effects of Precocene I were specific to maternal care, as we found no effect on non-care behaviours (self-grooming, general activity), female body mass, egg development time, or nymph weight at hatching. These effects were also likely to result from changes in maternal JH titres, as our molecular analyses confirmed that Precocene I reduced the expression of two key genes involved in the JH pathway, JHAMT and Kr-h1, while exposure to JHIII and JH agonists had no effect on gene expression. Together, these results provide both experimental and molecular evidence that JH plays a positive role in regulating maternal care after oviposition in the European earwig. More generally, our findings open new avenues for understanding the hormonal basis and evolutionary diversification of parental care strategies in insects.

在整个动物王国中，亲代抚育是提高后代生存和发展的关键行为。在昆虫中，一些研究表明，幼体激素（JH）是昆虫发育和繁殖的关键调节因子，在调节亲代抚育方面也起着重要作用。然而，最近在欧洲耳蜈蚣Forficula auricaria上的发现挑战了这一观点。在这项研究中，我们通过实验控制496只产卵后雌地鼠的JH水平，方法是将它们暴露于JHIII、两种JH激动剂（甲氧丁烯、吡丙醚）或一种JH产生抑制剂（Precocene I）。然后，我们量化了这些处理对三种关键母性护理行为的影响：收集卵子、保护卵子和梳理卵子。与JH在促进孕产妇保健方面的积极作用一致，我们发现通过I型早熟抑制JH合成导致所有三种形式的孕产妇保健减少。相比之下，补充JHIII或暴露于JH激动剂对这些护理行为没有可检测到的影响。观察到的1型早熟症的影响是针对母亲护理的，因为我们发现对非护理行为（自我梳理，一般活动），雌性体重，卵发育时间或孵化时若虫体重没有影响。这些影响也可能是由母体JH滴度的变化引起的，因为我们的分子分析证实，Precocene I降低了JH途径中涉及的两个关键基因JHAMT和k -h1的表达，而暴露于JHIII和JH激动剂对基因表达没有影响。总之，这些结果提供了实验和分子证据，证明JH在调节欧洲蠼螋产卵后的母体护理中起积极作用。更广泛地说，我们的发现为理解昆虫亲代抚育策略的激素基础和进化多样化开辟了新的途径。

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引用次数: 0

Acoustic correlates of physiological stress in a wild primate 野生灵长类动物生理应激的声学相关性。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-15 DOI: 10.1016/j.yhbeh.2025.105840

Ariadna Rangel-Negrín , Jacob C. Dunn , Alejandro Coyohua-Fuentes , David Roberto Chavira-Ramírez , Pedro A.D. Dias

Vocalizations potentially encode information about physiological states, yet there is little direct evidence linking vocal parameters to physiological stress in non-humans, including primates. We investigated whether male mantled howler monkey (Alouatta palliata) loud calls reflect physiological stress by analyzing the relationships between the acoustic parameters of loud calls and fecal glucocorticoid metabolite (fGCM) concentrations. Howler monkeys produce loud calls primarily in the context of intergroup competition, which has the potential to elicit physiological stress responses. We expected that elevated fGCM would be associated with loud call acoustics through changes in laryngeal tension (increasing fundamental frequency and vocal perturbations), respiratory control (affecting call duration and temporal patterning), and vocal tract configuration (modifying spectral properties). We analyzed 93 high-quality loud calls and assayed 242 fecal samples collected over a 10-year period from 23 adult males across seven groups in Los Tuxtlas (Mexico). We calculated 26 loud call acoustic measurements including spectral, temporal, and non-linear variables. Mixed-effects modeling revealed that acoustic features collectively explained 71 % of the variation in fGCM. Loud calls produced at higher fGCM were characterized by increased pitch, greater pitch instability, altered vocal tract resonances, increased voice roughness, and reduced tonal clarity. Among these features, changes in pitch showed the strongest association with fGCM. These findings establish a link between stress physiology and vocal production in howler monkeys, suggesting that internal physiological states manifest in acoustic signals that could convey information about caller condition.

发声可能编码有关生理状态的信息，但在包括灵长类动物在内的非人类中，几乎没有直接证据表明发声参数与生理压力有关。通过分析雄性毛吼猴（Alouatta palliata）叫声的声学参数与粪便糖皮质激素代谢物（fGCM）浓度之间的关系，研究毛吼猴叫声是否反映了生理应激。吼猴主要在群体间竞争的背景下发出响亮的叫声，这有可能引发生理应激反应。我们预计fGCM升高将通过喉部张力（增加基频和声音扰动）、呼吸控制（影响呼叫持续时间和时间模式）和声道结构（改变频谱特性）的变化与大声呼叫声学有关。我们分析了93种高质量的大声叫声，并分析了10年间从墨西哥洛斯图克斯特拉斯7个群体的23名成年男性中收集的242份粪便样本。我们计算了26个大声呼叫声学测量，包括光谱、时间和非线性变量。混合效应模型显示，声学特征共同解释了71%的fGCM变异。高fGCM产生的大声叫声的特征是音调增加，音调不稳定，声道共振改变，声音粗糙度增加，音调清晰度降低。在这些特征中，音高的变化与fGCM的关联最强。这些发现建立了吼猴应激生理和声音产生之间的联系，表明内部生理状态表现在声音信号中，可以传递有关呼叫者状况的信息。

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引用次数: 0

The role of paternal hair testosterone and cortisol levels in father-child bonding across the perinatal period in first-time fathers 父亲毛发睾酮和皮质醇水平在首次为人父的围产期亲子关系中的作用。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-15 DOI: 10.1016/j.yhbeh.2025.105838

Isabel Jaramillo , Jonathan Mamo-Wilhelmy , Luisa Bergunde , Marlene Karl , Kerstin Weidner , Susan Garthus-Niegel , Susann Steudte-Schmiedgen

Background

Previous research has linked short-term measures of the steroid hormones testosterone and cortisol to differences in parenting behavior in fathers. However, little research has focused on father-child bonding, the emotional dimension of the father-child relationship.

Objective

This study aims to investigate the associations of long-term testosterone and cortisol levels with father-child bonding during the postpartum period. In addition, we examined the change in cumulative testosterone levels during the transition to fatherhood.

Methods

As part of the prospective cohort study DREAM_HAIR, (expectant) fathers provided hair samples during their partners' pregnancy and at 8 weeks postpartum to quantify their long-term integrated testosterone and cortisol levels in the scalp-near 2 cm hair segment. Father-child bonding was assessed using the Postpartum Bonding Questionnaire at 8 weeks and 14 months postpartum.

Results

In the current sample of highly educated fathers with relatively low bonding difficulties, regression analyses, controlling for depressive symptoms, revealed no significant associations between postpartum hair testosterone, the change in hair testosterone from pregnancy to 8 weeks postpartum, and postpartum hair cortisol with father-child bonding. Further, we found no interaction between hair cortisol and testosterone or the change in hair testosterone from pregnancy to 8 weeks postpartum on father-child bonding.

Conclusion

The results indicate that long-term postpartum testosterone, its change from pregnancy to 8 weeks postpartum, and long-term postpartum cortisol are not associated with self-reported father-child bonding. Further research is needed to examine the differences of short and long-term steroids in relation to father-child bonding in heterogeneous samples. Additionally, conceptual research is necessary to examine the differences to mother-child bonding and to caregiving behavior.

背景：先前的研究将短期测量类固醇激素睾丸激素和皮质醇与父亲养育行为的差异联系起来。然而，很少有研究关注父子关系，父子关系的情感维度。目的：探讨产后长期睾酮和皮质醇水平与亲子关系的关系。此外，我们还检查了在转变为父亲期间累积睾酮水平的变化。方法：作为前瞻性队列研究DREAMHAIR的一部分，（准）父亲在其伴侣怀孕期间和产后8周提供头发样本，以量化其头皮近2厘米头发段的长期综合睾酮和皮质醇水平。分别于产后8周和14个月采用产后关系问卷对父子关系进行评估。结果：在目前受教育程度较高、亲子关系困难程度较低的父亲样本中，在控制抑郁症状的情况下，通过回归分析发现，产后毛发睾酮、妊娠至产后8周毛发睾酮变化、产后毛发皮质醇与亲子关系的关系均不显著。此外，我们发现头发皮质醇和睾酮之间没有相互作用，从怀孕到产后8周，头发睾酮的变化对父子关系没有影响。结论：长期产后睾酮及其从妊娠至产后8周的变化，以及长期产后皮质醇与自述亲子关系无关。需要进一步的研究来检查短期和长期类固醇在异质样本中与父子关系的差异。此外，有必要进行概念研究，以检验母子关系和照顾行为的差异。

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引用次数: 0

Juvenile hormone and maternal egg care in the European earwig (part I): Manipulation of JH, agonist, and precocene fails to induce the onset of egg care 欧洲蠼螋的幼崽激素和母性卵子护理（第一部分）：JH、激动剂和早熟的操作未能诱导卵子护理的开始。

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-14 DOI: 10.1016/j.yhbeh.2025.105841

Laura Pasquier, Violette Wallart, Séverine Devers, Joël Meunier , Charlotte Lécureuil

Parental care is a crucial behaviour in animals. Yet the mechanisms regulating its initiation remain poorly understood, particularly in insects. Juvenile hormone (JH) is widely recognized as a key hormonal regulator in insects that influences a broad diversity of physiological and behavioural traits, including parental care after oviposition. However, its role in triggering the onset of egg care remains unexplored. To address this, we experimentally manipulated JH levels in 194 pre-ovipositing European earwig females and tested whether they initiated care towards foreign eggs. Contrary to our predictions, topical application or injection of JH, methoprene (a JH analogue), precocene (a JH production inhibitor) or acetone (control) at varying doses failed to induce egg care or to prevent egg cannibalism. This rejection of foreign eggs was not due to experimental stress, as positive control females that had previously laid eggs cared for new foreign eggs, even after acetone exposure. These results demonstrate that neither the presence or absence of JH nor the mere presence of eggs is sufficient to induce maternal care in pre-ovipositing females. Instead, our findings suggest that additional signals beyond JH modulation and/or alternative hormonal pathways may be critical for initiating care behaviours in earwigs. Overall, this study advances our understanding of the complex regulatory mechanisms underlying parental care and the multifaceted role of JH in insect behaviour.

亲代抚育是动物的一项重要行为。然而，调控其启动的机制仍然知之甚少，特别是在昆虫中。幼虫激素（JH）被广泛认为是昆虫体内一种关键的激素调节因子，影响多种生理和行为特征，包括产卵后的亲代抚育。然而，它在触发卵子护理开始中的作用仍未被探索。为了解决这个问题，我们通过实验控制了194只产卵前的欧洲蠼螋雌性的JH水平，并测试了它们是否对外来卵产生了照顾。与我们的预测相反，局部应用或注射不同剂量的JH、methoprene（一种JH类似物）、preocene（一种JH生产抑制剂）或丙酮（对照）未能诱导卵子护理或防止卵子同类相食。这种对外来卵子的排斥不是由于实验压力，因为之前产卵的阳性对照雌性即使在接触丙酮后也会照顾新的外来卵子。这些结果表明，无论是存在或不存在JH还是仅仅存在卵子都不足以诱导产卵前雌性的母性护理。相反，我们的研究结果表明，除了JH调节和/或替代激素途径之外的其他信号可能对启动蠼螋的护理行为至关重要。总的来说，这项研究促进了我们对亲代抚育的复杂调节机制和JH在昆虫行为中的多方面作用的理解。

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引用次数: 0

Adjustment of paternal care in response to experimental variation in extra-pair mating opportunity in male zebra finches 雄性斑胸草雀对配对外交配机会的实验变化对父权照顾的调整

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-11 DOI: 10.1016/j.yhbeh.2025.105834

Navina D. Liebermann-Lilie , Benedikt Schniedermeyer , Anabel Kröhnert , Sepand Riyahi , Sylvia Kaiser , Tim Schmoll , Peter Korsten

Extra-pair paternity is prevalent in socially monogamous bird species with biparental care. Male extra-pair matings may coincide with paternal care provisioned to within-pair offspring. This may lead to a trade-off between obtaining additional fertilizations and securing offspring growth and survival through paternal care. In this pre-registered study, we manipulated the social environment of zebra finches to investigate how males trade off extra-pair mating versus providing paternal care. We compared paternal care provision between a social environment where two pairs bred together in a cage—resulting in an opportunity for extra-pair mating (Double-pair group)—to one with single breeding pairs (Single-pair group). We additionally measured plasma testosterone and corticosterone to identify hormonal correlates of male behavioral responses. To further increase the opportunity for extra-pair mating for the focal males from the Double-pair group we removed the male of the non-focal pair during chick rearing by the focal males. Contrary to our predictions, Double-pair males incubated more than Single-pair males. While we found substantial extra-pair paternity in the Double-pair group after removal of the non-focal males, male brood provisioning, chick growth and survival, and testosterone levels were not affected by the experimental increase in male extra-pair mating opportunity. Corticosterone levels were higher in Single-pair males between the first and replacement clutch. Refuting common assumptions, our findings provide no experimental evidence for a trade-off between extra-pair mating and paternal care. Males were able to pursue extra-pair fertilizations while they simultaneously secured the growth and survival of their within-pair offspring.

在双亲本照顾的一夫一妻制鸟类中，额外的父系关系很普遍。雄性的配偶外交配可能与雄性对配偶内后代的照顾相一致。这可能导致在获得额外受精和通过父系照顾确保后代生长和生存之间的权衡。在这项预先登记的研究中，我们操纵了斑胸草雀的社会环境，研究雄性斑胸草雀如何权衡额外配对交配与提供父亲照顾。我们比较了两种社会环境中的父系抚育，一种是两对在笼子里一起繁殖，从而有机会进行额外的交配（双对组），另一种是单对繁殖（单对组）。我们还测量了血浆睾酮和皮质酮，以确定男性行为反应的激素相关性。为了进一步增加双对组中焦点雄的额外配对机会，我们在焦点雄饲养雏鸟期间将非焦点雄移除了。与我们的预测相反，双配对的雄性比单配对的雄性孵化更多。虽然我们在双对组中发现了大量的额外配对父权，但雄性的产卵量、小鸡的生长和存活以及睾丸激素水平并没有受到雄性额外配对交配机会的影响。在第一窝和替换窝之间，单对雄鼠的皮质酮水平较高。与通常的假设相反，我们的研究结果没有提供实验证据来证明额外配对交配和父亲照顾之间的权衡。雄性能够追求额外的配对受精，同时确保其配对内后代的生长和生存。

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引用次数: 0

Endocrine and behavioral responses to ecological and social challenges in wild Geoffroy's spider monkeys 野生Geoffroy蜘蛛猴对生态和社会挑战的内分泌和行为反应

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-10 DOI: 10.1016/j.yhbeh.2025.105824

Juliane Damm , Pedro A.D. Dias , Ariadna Rangel-Negrín , Colleen M. Schaffner , Fabrizio Dell'Anna , Filippo Aureli

To maintain homeostasis during external and internal challenges, vertebrates activate allostatic systems, such as the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, animals can use behavioral responses to address such challenges, which may result in the reduction of allostatic processes. We assessed whether HPA activation is influenced by subgroup formation patterns during ecological and social challenges. We selected Geoffroy's spider monkeys (Ateles geoffroyi) as study subjects, because they are characterized by a high degree of fission-fusion dynamics. We expected spider monkeys to address challenges by being in smaller subgroups when food availability is lower, in larger subgroups when perceived predation risk is higher, and either in larger subgroups or in proximity of more individuals when the likelihood of between-group encounters is higher. For 20 months, we collected behavioral data and fecal samples from 30 wild adult and subadult spider monkeys at the Otoch Ma'ax Yetel Kooh reserve in the Yucatán peninsula, Mexico, and assessed food availability in their home range. In support of our predictions, fecal glucocorticoid metabolite (fGCM) concentrations were negatively associated with food availability, and they were lower when in smaller subgroups than in larger subgroups during low food availability. Fecal GCM concentrations were positively associated with alarm call rates and were lower when in larger subgroups than when in smaller subgroups during high perceived predation risk. We found no evidence for an association between fGCM concentrations and the likelihood of between-group encounters. Overall, subgroup formation patterns interact with HPA activity to successfully address ecological challenges in wild Geoffroy's spider monkeys. Our study highlights the importance of assessing ecological challenges and behavioral responses when interpreting HPA activation in the wild.

为了在外部和内部挑战中保持体内平衡，脊椎动物激活适应系统，如下丘脑-垂体-肾上腺（HPA）轴。此外，动物可以使用行为反应来应对这些挑战，这可能导致适应过程的减少。我们评估了在生态和社会挑战中HPA的激活是否受到亚群形成模式的影响。我们选择杰弗里的蜘蛛猴（Ateles geoffroyi）作为研究对象，因为它们具有高度的裂变融合动力学特征。我们期望蜘蛛猴在食物供应不足时，能在较小的亚群中应对挑战；当感知到被捕食的风险较高时，能在较大的亚群中应对挑战；当群体间相遇的可能性较高时，能在较大的亚群中应对挑战；在20个月的时间里，我们在墨西哥Yucatán半岛的Otoch Ma'ax Yetel Kooh保护区收集了30只野生成年和亚成年蜘蛛猴的行为数据和粪便样本，并评估了它们家乡范围内的食物供应情况。为了支持我们的预测，粪便糖皮质激素代谢物（fGCM）浓度与食物可得性呈负相关，在食物可得性低的情况下，较小亚组的粪便糖皮质激素代谢物浓度低于较大亚组。粪便GCM浓度与报警率呈正相关，并且在高感知捕食风险时，较大亚组中的浓度低于较小亚组中的浓度。我们没有发现fGCM浓度与组间接触可能性之间存在关联的证据。总的来说，亚群形成模式与HPA活动相互作用，成功地解决了野生Geoffroy蜘蛛猴的生态挑战。我们的研究强调了在解释野生HPA激活时评估生态挑战和行为反应的重要性。

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引用次数: 0

Chronic social isolation, crowding, and instability distinctly impact reproductive function in adult female Wistar rats 长期的社会隔离、拥挤和不稳定明显影响成年雌性Wistar大鼠的生殖功能

IF 2.4 3区医学 Q2 BEHAVIORAL SCIENCES

Hormones and Behavior

Pub Date : 2025-10-10 DOI: 10.1016/j.yhbeh.2025.105835

Marilou Poitras , Adèle Labonté , Aliya F. Qureshi , Cassandra Blackburn , Zoé M.I. Gracovetsky , Rutaaba Fasih , Hélène Plamondon

Social stressors represent highly relevant stress models which remain understudied in females. Concordantly, little is known of the impact of different types of social stress on female reproductive functioning, despite close interactions between the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis. This study provides a comprehensive assessment of reproductive functioning in female rats following exposure to three social stress paradigms. 112 regularly cycling adult female Wistar rats were exposed to 21 days of isolation, crowding, social instability, control housing (daily cage changes) or regular housing. Rats were then euthanized (in proestrus or diestrus) or underwent paced-mating and fertility assessments. Estrous cyclicity, uterine horn weight, hypothalamic expression of kisspeptin (Kiss1), gonadotropin-inhibitory hormone (GnIH), estrogen receptors alpha (ERα), and glucocorticoid receptors (GR), serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P4), and corticosterone (CORT), as well as ovarian follicle counts were assessed. Findings show isolation to increase hopping behaviors, decrease early follicle counts, uterine weight, and GnIH, as well as increase FSH levels. In crowded rats, expression of GnIH and ERα were reduced, paralleled by fewer days spent in proestrus and increased hopping behaviors. Following instability, rats presented decreased estrous cyclicity, reduced uterine weight, and diminished ovarian reserve, despite minimal changes at the hypothalamic level. Paced mating exposure increased CORT in all groups except instability and crowding. Overall, social stressors presented distinct consequences on reproduction, highlighting their relevance as stress models and the importance of gaining a better understanding of social stress-induced reproductive dysfunction in females.

社会压力源代表高度相关的压力模型，在女性中仍未得到充分研究。同样，尽管下丘脑-垂体-肾上腺（HPA）轴和下丘脑-垂体-性腺（HPG）轴之间存在密切的相互作用，但人们对不同类型的社会压力对女性生殖功能的影响知之甚少。本研究对三种社会应激模式对雌性大鼠生殖功能的影响进行了全面评估。将112只定期循环的成年雌性Wistar大鼠暴露于21天的隔离、拥挤、社会不稳定、控制住房（每日更换笼子）或常规住房中。然后对大鼠实施安乐死（在发情前期或发情后期）或进行节奏交配和生育评估。评估发情周期、子宫角重量、下丘脑接吻素（Kiss1）、促性腺激素抑制激素（GnIH）、雌激素受体α (ERα)和糖皮质激素受体（GR）的表达、血清黄体生成素（LH）、促卵泡激素（FSH）、雌二醇（E2）、黄体酮（P4）、皮质酮（CORT）以及卵巢卵泡计数。研究结果表明，分离可增加跳跃行为，降低早期卵泡计数，子宫重量和GnIH，并增加FSH水平。在拥挤的大鼠中，GnIH和ERα的表达减少，与发情天数减少和跳跃行为增加有关。不稳定后，大鼠表现为发情周期下降，子宫重量减少，卵巢储备减少，尽管下丘脑水平变化很小。除不稳定和拥挤外，有节奏的交配暴露增加了所有组的CORT。总的来说，社会压力源对生殖产生了不同的影响，突出了它们作为压力模型的相关性，以及更好地理解社会压力诱导的女性生殖功能障碍的重要性。

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