Pub Date : 2023-01-01DOI: 10.21608/ha.2022.171318.1092
Shady Z Said, A. Awwad, Mohamed Konsowa, A. Motawi
{"title":"Characteristics and management of testicular torsion patients presented to a tertiary care hospital: A prospective cohort study","authors":"Shady Z Said, A. Awwad, Mohamed Konsowa, A. Motawi","doi":"10.21608/ha.2022.171318.1092","DOIUrl":"https://doi.org/10.21608/ha.2022.171318.1092","url":null,"abstract":"","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86038943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/ha.2022.176513.1095
A. Moussa, O. Shaeer, Yasser K. Saleh, D. Sayed, Mohamed Farag
{"title":"Assessment of ejaculatory function in men undergoing malleable penile prosthesis implant surgery","authors":"A. Moussa, O. Shaeer, Yasser K. Saleh, D. Sayed, Mohamed Farag","doi":"10.21608/ha.2022.176513.1095","DOIUrl":"https://doi.org/10.21608/ha.2022.176513.1095","url":null,"abstract":"","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"131 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73519307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/ha.2022.173398.1093
Shabieb Abdelbaky, Khaled Elgamal, M. El-Tabey, Aly Afefy
{"title":"Evaluation of sexual function following bipolar vaporization versus monopolar transurethral resection of the prostate","authors":"Shabieb Abdelbaky, Khaled Elgamal, M. El-Tabey, Aly Afefy","doi":"10.21608/ha.2022.173398.1093","DOIUrl":"https://doi.org/10.21608/ha.2022.173398.1093","url":null,"abstract":"","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76637265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.21608/ha.2022.176979.1096
A. Moussa, M. Amer, Hosam H. Awad, H. Saleh, M. Abdelfatah
{"title":"Comparative study between transverse and longitudinal incisions in microTESE in nonobstructive azoospermic patients","authors":"A. Moussa, M. Amer, Hosam H. Awad, H. Saleh, M. Abdelfatah","doi":"10.21608/ha.2022.176979.1096","DOIUrl":"https://doi.org/10.21608/ha.2022.176979.1096","url":null,"abstract":"","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87090798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ha.2021.111926.1083
Rashad M. Mostafa, Hoda Y. Abdallah, H. Eissa, D. Ibrahim, S. Ibrahim, H. Saad
Background: MicroRNAs (miRNAs) play essential roles in human spermatogenesis, but little is known about seminal plasma miRNAs in infertile men. Aim: To assess miRNA-34b, miRNA-181a, and miRNA-429 expression profiles in seminal plasma of patients with nonobstructive azoospermia (NOA) and to correlate these expression profiles with their clinical, laboratory, and histopathological features. Patients and Methods: This was a prospective case–control study which included two groups: 50 males with NOA and 50 healthy fertile males who attended the Andrology Outpatient Clinic, the Genetics Unit, and a private IVF Center. Semen analysis and assessment of the three miRNAs expression profiles in seminal plasma were done by real-time PCR for both groups. Hormonal profile assessment (follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin), testicular sperm extraction, and histopathology were done for the patients’ group. Results: In this study, there were statistically significant upregulations of both miRNA-429 and miRNA-181a in the patients’ group compared with controls (P<0.001), which was not the case for miRNA34b (P=0.259). There were statistically significant relationships between the three miRNAs, testicular sperm extraction results, and histopathological patterns (P<0.05).There were significant positive correlations between miRNA34b, miRNA-429, and follicle-stimulating hormone(r=0.466, P=0.001; r=0.375, P=0.009, respectively) and significant negative correlations between miRNA34b, miRNA-181a, and Johnsen’s score (r=-0.287, P=0.048; r=-0.351, P=0.015, respectively). There was statistically significant negative correlation between miRNA-429 and testosterone (r=-0.330, P=0.022). Conclusion: The expression levels of miRNA 181aandmiRNA-429 only were upregulated in NOA patients compared with controls. Thus, they may represent useful noninvasive biomarkers for NOA.
{"title":"Assessment of expression profiles of three microRNAs and their clinical, laboratory, and histopathological correlations in non-obstructive azoospermia : A controlled study","authors":"Rashad M. Mostafa, Hoda Y. Abdallah, H. Eissa, D. Ibrahim, S. Ibrahim, H. Saad","doi":"10.21608/ha.2021.111926.1083","DOIUrl":"https://doi.org/10.21608/ha.2021.111926.1083","url":null,"abstract":"Background: MicroRNAs (miRNAs) play essential roles in human spermatogenesis, but little is known about seminal plasma miRNAs in infertile men. Aim: To assess miRNA-34b, miRNA-181a, and miRNA-429 expression profiles in seminal plasma of patients with nonobstructive azoospermia (NOA) and to correlate these expression profiles with their clinical, laboratory, and histopathological features. Patients and Methods: This was a prospective case–control study which included two groups: 50 males with NOA and 50 healthy fertile males who attended the Andrology Outpatient Clinic, the Genetics Unit, and a private IVF Center. Semen analysis and assessment of the three miRNAs expression profiles in seminal plasma were done by real-time PCR for both groups. Hormonal profile assessment (follicle-stimulating hormone, luteinizing hormone, testosterone, and prolactin), testicular sperm extraction, and histopathology were done for the patients’ group. Results: In this study, there were statistically significant upregulations of both miRNA-429 and miRNA-181a in the patients’ group compared with controls (P<0.001), which was not the case for miRNA34b (P=0.259). There were statistically significant relationships between the three miRNAs, testicular sperm extraction results, and histopathological patterns (P<0.05).There were significant positive correlations between miRNA34b, miRNA-429, and follicle-stimulating hormone(r=0.466, P=0.001; r=0.375, P=0.009, respectively) and significant negative correlations between miRNA34b, miRNA-181a, and Johnsen’s score (r=-0.287, P=0.048; r=-0.351, P=0.015, respectively). There was statistically significant negative correlation between miRNA-429 and testosterone (r=-0.330, P=0.022). Conclusion: The expression levels of miRNA 181aandmiRNA-429 only were upregulated in NOA patients compared with controls. Thus, they may represent useful noninvasive biomarkers for NOA.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87730997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ha.2022.140442.1087
Nesreen M. Aboraia, Talal Abdel Raheem, Eslam Elsawah, A. Younis
Background: Erectile dysfunction (ED) is considered the prime sexual dysfunction attracting public attention among men all over the world. It ranges from partial decrease in penile rigidity to a complete erectile failure. To overcome this issue, sex-enhancing medications have become popular among men. Aim: The main objective of this work was to determine the prevalence, demographics, and sexual features of sex-enhancing medications users among Egyptians. Patients and Methods: A total of 1916 adult males were included in the present study. This cross-sectional study was conducted between August 2020 and July 2021. Participants were invited to fill a self-structured questionnaire through ‘Google Forms.’ The form included three main sections for sociodemographic data; sexual activity, and sex-enhancing medication history and brief sexual functioning inventory score analysis (BSFI). Results: Our finding showed that 48.4% of the subjects used sex-enhancement drugs. After completing the BSFI score variables, the results revealed that there was a highly statistically significant difference for the total BSFI score between sex-enhancement drug users and nonusers (23.4±5.7 and 21.02±4.5, respectively), with less than 0.001. Regarding the drugs used, the majority (67.9%) used sildenafil. Strengths and limitations: In the Egyptian society, talking about sex problems concerns most males and they get ashamed when talking about it. Sex-enhancement drugs are being circulated in Egypt in a nonmedical way. Conclusion: Urban residency, marriage, high education, job, low-to-middle socioeconomic status, smoking, drinking alcohol, and having chronic hypertension and/or diabetes mellitus were identified as features of sex-enhancing pharmaceutical users, with impairment of sexual function among them.
{"title":"Users under the influence of sex-enhancing medications: prevalence, demographics, and sexual features","authors":"Nesreen M. Aboraia, Talal Abdel Raheem, Eslam Elsawah, A. Younis","doi":"10.21608/ha.2022.140442.1087","DOIUrl":"https://doi.org/10.21608/ha.2022.140442.1087","url":null,"abstract":"Background: Erectile dysfunction (ED) is considered the prime sexual dysfunction attracting public attention among men all over the world. It ranges from partial decrease in penile rigidity to a complete erectile failure. To overcome this issue, sex-enhancing medications have become popular among men. Aim: The main objective of this work was to determine the prevalence, demographics, and sexual features of sex-enhancing medications users among Egyptians. Patients and Methods: A total of 1916 adult males were included in the present study. This cross-sectional study was conducted between August 2020 and July 2021. Participants were invited to fill a self-structured questionnaire through ‘Google Forms.’ The form included three main sections for sociodemographic data; sexual activity, and sex-enhancing medication history and brief sexual functioning inventory score analysis (BSFI). Results: Our finding showed that 48.4% of the subjects used sex-enhancement drugs. After completing the BSFI score variables, the results revealed that there was a highly statistically significant difference for the total BSFI score between sex-enhancement drug users and nonusers (23.4±5.7 and 21.02±4.5, respectively), with less than 0.001. Regarding the drugs used, the majority (67.9%) used sildenafil. Strengths and limitations: In the Egyptian society, talking about sex problems concerns most males and they get ashamed when talking about it. Sex-enhancement drugs are being circulated in Egypt in a nonmedical way. Conclusion: Urban residency, marriage, high education, job, low-to-middle socioeconomic status, smoking, drinking alcohol, and having chronic hypertension and/or diabetes mellitus were identified as features of sex-enhancing pharmaceutical users, with impairment of sexual function among them.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"211 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80665185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/ha.2022.135466.1086
Emad el din Kamal, Azza Hassan, Amal Hosni, Aya Y Badran
{"title":"Seminal clusterin level as a predictor for spermatogenesis before testicular sperm extraction","authors":"Emad el din Kamal, Azza Hassan, Amal Hosni, Aya Y Badran","doi":"10.21608/ha.2022.135466.1086","DOIUrl":"https://doi.org/10.21608/ha.2022.135466.1086","url":null,"abstract":"","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86731479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-16DOI: 10.21608/ha.2021.111879.1082
Rashad M. Mostafa, N. Soliman, Nourhan S. Mohamed, H. Saad
Background: Antisperm antibody (ASA) is defined as an immunoglobulin with antibody activity against a sperm antigen that plays a role in fertility. It has been hypothesized that hepatitis C virus (HCV) infection of lymphocytes is the cause for the increased autoimmune phenomena and autoantibody production reported in association with HCV. The development of ASA has been previously reported in cases with human papilloma virus (HPV), where infertile males with HPV in semen showed higher ASA percentages compared with infertile males with no HPV in semen. Aim: To investigate the influence of HCV infection on the development of ASAs in diagnosed HCV male patients. Patients and Methods: The study included two groups: group one included 25 patients who were infected with HCV, and group two included 25 healthy controls. Semen analyses by CASA were performedand serum and semen samples were taken for all patients to detect ASA by enzyme-linked immunosorbent assay. Results: In the patient group, 28% were positive for ASA in semen versus 4% in the control group with a statistically significant difference between the two groups ( P =0.049). ASA levels in serum were positive in 36% of patients versus 12% in the control group with a statistically significant difference between the two groups ( P =0.047). There were significant negative correlations between progressive motility, agglutination, and the level of patient’s ASA in both serum (r= ‒ 0.635, P <0.001, r= ‒ 0.749, P <0.001, respectively) and semen (r= ‒ 0.764, P =0.001; r= ‒ 1, P <0.001, respectively). Conclusion: The coincidence of ASA in males with hepatitis C infection diseases was significantly higher than healthy controls.
背景:抗精子抗体(ASA)是一种具有抗精子抗原抗体活性的免疫球蛋白，在生育中起作用。据推测，丙型肝炎病毒(HCV)感染淋巴细胞是HCV相关的自身免疫现象和自身抗体产生增加的原因。ASA的发展在人类乳头瘤病毒(HPV)病例中已有报道，其中精液中含有HPV的不育男性比精液中没有HPV的不育男性显示出更高的ASA百分比。目的:探讨HCV感染对HCV男性患者asa发展的影响。患者和方法:研究分为两组:第一组25例HCV感染患者，第二组25例健康对照。采用CASA对所有患者进行精液分析，并采集血清和精液样本，采用酶联免疫吸附法检测ASA。结果:患者组精液ASA阳性率为28%，对照组为4%，两组差异有统计学意义(P =0.049)。36%的患者血清中ASA水平呈阳性，对照组为12%，两组差异有统计学意义(P =0.047)。血清(r= - 0.635, P <0.001, r= - 0.749, P <0.001)和精液(r= - 0.764, P =0.001)进展性运动、凝集与患者ASA水平呈显著负相关;r= - 1, P <0.001)。结论:男性丙型肝炎患者ASA符合率明显高于健康对照组。
{"title":"Assessment of Antisperm Antibodies in Patients with Hepatitis C Virus Infection : A controlled study","authors":"Rashad M. Mostafa, N. Soliman, Nourhan S. Mohamed, H. Saad","doi":"10.21608/ha.2021.111879.1082","DOIUrl":"https://doi.org/10.21608/ha.2021.111879.1082","url":null,"abstract":"Background: Antisperm antibody (ASA) is defined as an immunoglobulin with antibody activity against a sperm antigen that plays a role in fertility. It has been hypothesized that hepatitis C virus (HCV) infection of lymphocytes is the cause for the increased autoimmune phenomena and autoantibody production reported in association with HCV. The development of ASA has been previously reported in cases with human papilloma virus (HPV), where infertile males with HPV in semen showed higher ASA percentages compared with infertile males with no HPV in semen. Aim: To investigate the influence of HCV infection on the development of ASAs in diagnosed HCV male patients. Patients and Methods: The study included two groups: group one included 25 patients who were infected with HCV, and group two included 25 healthy controls. Semen analyses by CASA were performedand serum and semen samples were taken for all patients to detect ASA by enzyme-linked immunosorbent assay. Results: In the patient group, 28% were positive for ASA in semen versus 4% in the control group with a statistically significant difference between the two groups ( P =0.049). ASA levels in serum were positive in 36% of patients versus 12% in the control group with a statistically significant difference between the two groups ( P =0.047). There were significant negative correlations between progressive motility, agglutination, and the level of patient’s ASA in both serum (r= ‒ 0.635, P <0.001, r= ‒ 0.749, P <0.001, respectively) and semen (r= ‒ 0.764, P =0.001; r= ‒ 1, P <0.001, respectively). Conclusion: The coincidence of ASA in males with hepatitis C infection diseases was significantly higher than healthy controls.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"181 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76469187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.21608/HA.2020.50021.1073
I. Younis, M. Ibrahim, Fatima-Alzahraa A Abdel-Munem
Background: Many people have sexual dysfunctions for the simple reason that they believe in certain fallacies and mythical ideas. Aim: To assess the opinion of female doctors compared with nonmedical women regarding sexual myths. Patients and Methods: Participants included 822 married women divided into two groups: a medical group including 432 (52.6%) female doctors (not working in the field of sexual medicine) and a nonmedical group including 390 (47.4%) women. The tool was a self-report questionnaire to assess opinions about eight sexual myths in addition to demographic data. Results: Most nonmedical women believed in seven of the eight myths, whereas most female doctors believed in only two myths. Age of women, their residence, and their educational level were determining factors in believing sexual myths. Conclusion: Nonmedical women are more liable to believe in sexual myths. The need to spread proper sexual knowledge via sexual education is a dire need.
{"title":"Believe it or not: Views of a sample of Egyptian women about sexual myths","authors":"I. Younis, M. Ibrahim, Fatima-Alzahraa A Abdel-Munem","doi":"10.21608/HA.2020.50021.1073","DOIUrl":"https://doi.org/10.21608/HA.2020.50021.1073","url":null,"abstract":"Background: Many people have sexual dysfunctions for the simple reason that they believe in certain fallacies and mythical ideas. Aim: To assess the opinion of female doctors compared with nonmedical women regarding sexual myths. Patients and Methods: Participants included 822 married women divided into two groups: a medical group including 432 (52.6%) female doctors (not working in the field of sexual medicine) and a nonmedical group including 390 (47.4%) women. The tool was a self-report questionnaire to assess opinions about eight sexual myths in addition to demographic data. Results: Most nonmedical women believed in seven of the eight myths, whereas most female doctors believed in only two myths. Age of women, their residence, and their educational level were determining factors in believing sexual myths. Conclusion: Nonmedical women are more liable to believe in sexual myths. The need to spread proper sexual knowledge via sexual education is a dire need.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"68 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.21608/HA.2020.29700.1061
E. Kamal, Aya Y Badran, W. Khalifa, A. Mahgoob, Mohammed Abukrisha, Reham Abdel Gaber
Background: Diabetes mellitus (DM) is a well-known metabolic disorder affecting a large population worldwide. Both types of DM could have detrimental effects on semen parameters as well as the hormonal profile of the affected males. Objective: On designing the current study, we sought to evaluate the effect of long-term control of DM by measuring glycosylated hemoglobin (HbA1c) level and detect its possible correlation with semen parameters and hormonal profile of male patients with DM. Patients and Methods: A prospective case–control study was conducted on 60 males with DM and 40 matched controls. All participants were subjected to conventional semen analysis and measurement of free and total testosterone, follicle-stimulating hormone, luteinizing hormone, and prolactin levels by enzyme-linked immunosorbent assay technique. Measurement of HbA1c level was made for all participants. Results: A significant negative correlation was found between HbA1c and free testosterone levels, whereas a significant positive correlation between HbA1c and prolactin levels in patients with DM. No significant correlation was reported between HbA1c and semen parameters in patients with DM. Conclusion: Patients with DM have significantly lower semen parameters and reproductive hormone levels than matched healthy controls which might impair their fecundity and reproductive capacity. We do recommend that all males with abnormal semen analysis should undergo screening for DM.
{"title":"Semen parameters in Egyptian diabetic patients and its correlation with glycosylated hemoglobin level: A case - control study","authors":"E. Kamal, Aya Y Badran, W. Khalifa, A. Mahgoob, Mohammed Abukrisha, Reham Abdel Gaber","doi":"10.21608/HA.2020.29700.1061","DOIUrl":"https://doi.org/10.21608/HA.2020.29700.1061","url":null,"abstract":"Background: Diabetes mellitus (DM) is a well-known metabolic disorder affecting a large population worldwide. Both types of DM could have detrimental effects on semen parameters as well as the hormonal profile of the affected males. Objective: On designing the current study, we sought to evaluate the effect of long-term control of DM by measuring glycosylated hemoglobin (HbA1c) level and detect its possible correlation with semen parameters and hormonal profile of male patients with DM. Patients and Methods: A prospective case–control study was conducted on 60 males with DM and 40 matched controls. All participants were subjected to conventional semen analysis and measurement of free and total testosterone, follicle-stimulating hormone, luteinizing hormone, and prolactin levels by enzyme-linked immunosorbent assay technique. Measurement of HbA1c level was made for all participants. Results: A significant negative correlation was found between HbA1c and free testosterone levels, whereas a significant positive correlation between HbA1c and prolactin levels in patients with DM. No significant correlation was reported between HbA1c and semen parameters in patients with DM. Conclusion: Patients with DM have significantly lower semen parameters and reproductive hormone levels than matched healthy controls which might impair their fecundity and reproductive capacity. We do recommend that all males with abnormal semen analysis should undergo screening for DM.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"22 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75986745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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