S. Ismail, N. E. Abdel-Azim, D. Habib, Mariam Zaky, M. Saleh, A. Abbas
Objective: to investigate the prevalence and possible risk factors that may cause FSD in Upper Egypt women and to study their attitude towards their sexual dysfunction. Study design: a cross sectional hospital based study setting: Assiut University Hospital, Assiut, Egypt Materials and methods: We included consecutive healthy sexually active Egyptian women aged between 18 and 55 years who had visited the hospital for routine check-up, women accompanying other patients and non medical female hospital staff. We used the Arabic version of the Female Sexual Function Index (Ar-FSFI) in the interview to evaluate the sexual functions or problems during the last month. The cut-off score used to indicate sexual dysfunction was 28.1. Results: a total of 583 healthy sexually active married females were approached, of whom 500 (85.8%) accepted to participate in the study. About 339 women (67.8%) had sexual dysfunction. The total mean FSFI score for women with sexual dysfunction was 16.73±7.50 compared to 31.31±1.43 for women without sexual dysfunction (p<0.001). FSD was significantly more common in older (p=0.000), less educated women (p=0.000), house wives (p=0.000) and women who live in rural communities (p=0.009). Logistic regression using the risk factors for the presence of FSD was performed. Age, residence, level of education, menopause, number of children, duration of marriage and the use of contraception were statistically significant risk factors that may predict the presence of FSD in participating women. Conclusions: The reported high prevalence of FSD indicates that sexual dysfunction is an important public health problem in Upper Egypt that has not been investigated. It highlights the need to establish sexual disorders clinics in our environment and to improve physicians’ awareness and competency in FSD. INTRODUCTION Female sexual dysfunction (FSD) is a common health concern. It is manifested by difficulties getting aroused, lubricated, or having an orgasm despite adequate stimulation[1, 2]. According to the published epidemiological studies, the prevalence of FSD is ranging from 19% to 63%, and increases up to 93% in certain age groups[38]. However, it remains a taboo subject in many countries including Egypt[9, 10]. Cultural and religious values, poor sexual education, and feelings of embarrassment reduce women's chances of getting help[11]. Female sexual function may be affected by several interpersonal, psychological, physiological, medical, social, and cultural factors[3]. Studies have shown that FSD might have a negative impact on women's sense of well
{"title":"Prevalence, Risk Factors and Women's Attitude towards Female Sexual Dysfunction in Upper Egypt: Hospital based study","authors":"S. Ismail, N. E. Abdel-Azim, D. Habib, Mariam Zaky, M. Saleh, A. Abbas","doi":"10.21608/HA.2017.4546","DOIUrl":"https://doi.org/10.21608/HA.2017.4546","url":null,"abstract":"Objective: to investigate the prevalence and possible risk factors that may cause FSD in Upper Egypt women and to study their attitude towards their sexual dysfunction. Study design: a cross sectional hospital based study setting: Assiut University Hospital, Assiut, Egypt Materials and methods: We included consecutive healthy sexually active Egyptian women aged between 18 and 55 years who had visited the hospital for routine check-up, women accompanying other patients and non medical female hospital staff. We used the Arabic version of the Female Sexual Function Index (Ar-FSFI) in the interview to evaluate the sexual functions or problems during the last month. The cut-off score used to indicate sexual dysfunction was 28.1. Results: a total of 583 healthy sexually active married females were approached, of whom 500 (85.8%) accepted to participate in the study. About 339 women (67.8%) had sexual dysfunction. The total mean FSFI score for women with sexual dysfunction was 16.73±7.50 compared to 31.31±1.43 for women without sexual dysfunction (p<0.001). FSD was significantly more common in older (p=0.000), less educated women (p=0.000), house wives (p=0.000) and women who live in rural communities (p=0.009). Logistic regression using the risk factors for the presence of FSD was performed. Age, residence, level of education, menopause, number of children, duration of marriage and the use of contraception were statistically significant risk factors that may predict the presence of FSD in participating women. Conclusions: The reported high prevalence of FSD indicates that sexual dysfunction is an important public health problem in Upper Egypt that has not been investigated. It highlights the need to establish sexual disorders clinics in our environment and to improve physicians’ awareness and competency in FSD. INTRODUCTION Female sexual dysfunction (FSD) is a common health concern. It is manifested by difficulties getting aroused, lubricated, or having an orgasm despite adequate stimulation[1, 2]. According to the published epidemiological studies, the prevalence of FSD is ranging from 19% to 63%, and increases up to 93% in certain age groups[38]. However, it remains a taboo subject in many countries including Egypt[9, 10]. Cultural and religious values, poor sexual education, and feelings of embarrassment reduce women's chances of getting help[11]. Female sexual function may be affected by several interpersonal, psychological, physiological, medical, social, and cultural factors[3]. Studies have shown that FSD might have a negative impact on women's sense of well","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"53 1","pages":"143-153"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83395785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-01DOI: 10.21608/ha.2017.904.1001
H. Sabry, Ahmed H. Hamed, J. Sabry, Osama H. Abdel-Salama
Introduction: Endothelial dysfunction is a central etiologic factor in the development of atherosclerosis and systemic vascular disease, which includes erectile dysfunction. YKL-40 has been suggested to be a new marker of inflammation, atherosclerosis, and endothelial dysfunction. Aim: To estimate serum levels of YKL40, as a new serum marker of endothelial dysfunction, in patients with arteriogenic erectile dysfunction. Patients and Methods: Hundred subjects including 50 with arteriogenic erectile dysfunction and 50 healthy as a control group were enrolled to the study. Serum YKL-40 levels were measured in patients and controls using ELISA technique. Results: Serum YKL-40 levels was significantly elevated in arteriogenic ED patients compared with controls. Positive significant correlations were found between serum levels of YKL40 and patients’ age (r=0.588, p=0.001), duration of erectile dysfunction (r=0.673, p=0.001), BMI (r=0.598, p=0.001). The patients with hypertension had significantly elevated YKL-40 levels than those who were normotensive (164.88 ± 191.73 Vs 60.22 ± 26.44, respectively). Conclusion: Serum levels of YKL-40 are elevated in arteriogenic ED patients denoting that endothelial dysfunction play a role in the pathogenesis of arteriogenic ED and YKL-40 as a novel marker of endothelial dysfunction could be a marker of arteriogenic erectile dysfunction.
导读:内皮功能障碍是动脉粥样硬化和系统性血管疾病(包括勃起功能障碍)发展的中心病因。YKL-40已被认为是炎症、动脉粥样硬化和内皮功能障碍的新标志物。目的:评价血管源性勃起功能障碍患者血清内皮功能障碍标志物YKL40的水平。患者与方法:纳入100例受试者，其中50例为动脉源性勃起功能障碍患者，50例为健康对照组。采用ELISA技术检测患者和对照组血清YKL-40水平。结果:与对照组相比，动脉性ED患者血清YKL-40水平明显升高。血清YKL40水平与患者年龄(r=0.588, p=0.001)、勃起功能障碍持续时间(r=0.673, p=0.001)、BMI (r=0.598, p=0.001)呈正相关。高血压患者YKL-40水平明显高于正常组(分别为164.88±191.73 Vs 60.22±26.44)。结论:动脉性ED患者血清YKL-40水平升高，提示血管内皮功能障碍参与了动脉性ED的发病机制，YKL-40作为一种新的血管内皮功能障碍标志物可作为动脉性勃起功能障碍的标志物。
{"title":"YKL-40: An Emerging Biomarker of Endothelial Dysfunction in Arteriogenic Erectile Dysfunction","authors":"H. Sabry, Ahmed H. Hamed, J. Sabry, Osama H. Abdel-Salama","doi":"10.21608/ha.2017.904.1001","DOIUrl":"https://doi.org/10.21608/ha.2017.904.1001","url":null,"abstract":"Introduction: Endothelial dysfunction is a central etiologic factor in the development of atherosclerosis and systemic vascular disease, which includes erectile dysfunction. YKL-40 has been suggested to be a new marker of inflammation, atherosclerosis, and endothelial dysfunction. Aim: To estimate serum levels of YKL40, as a new serum marker of endothelial dysfunction, in patients with arteriogenic erectile dysfunction. Patients and Methods: Hundred subjects including 50 with arteriogenic erectile dysfunction and 50 healthy as a control group were enrolled to the study. Serum YKL-40 levels were measured in patients and controls using ELISA technique. Results: Serum YKL-40 levels was significantly elevated in arteriogenic ED patients compared with controls. Positive significant correlations were found between serum levels of YKL40 and patients’ age (r=0.588, p=0.001), duration of erectile dysfunction (r=0.673, p=0.001), BMI (r=0.598, p=0.001). The patients with hypertension had significantly elevated YKL-40 levels than those who were normotensive (164.88 ± 191.73 Vs 60.22 ± 26.44, respectively). Conclusion: Serum levels of YKL-40 are elevated in arteriogenic ED patients denoting that endothelial dysfunction play a role in the pathogenesis of arteriogenic ED and YKL-40 as a novel marker of endothelial dysfunction could be a marker of arteriogenic erectile dysfunction.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"34 1","pages":"98-104"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88047730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-01DOI: 10.21608/HA.2017.1571.1013
T. Tawfik, M. Aref, S. G. Din, Mohamed Abd El Mawgood, A. Khattab
Introduction: several studies demonstrated the potential role of serum leptin in patients with premature ejaculation. Aim: we aimed in this study to evaluate the correlation between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation and healthy controls. Patients and Methods: this study was carried out on 80 consecutive patients and controls. Body mass index was measured in the patients and the controls. Serum leptin was measured in both groups at the end of the study. Additionally, the patients and the controls were asked to measure intra vaginal ejaculation latency time (IELT) by stop watch handled by their wives for 2 successive months. Results: our prospective analysis revealed a highly significant association between body mass index and serum leptin and intra-vaginal ejaculation latency time among the cases (p-value < 0.001, <0.001 respectively). Additionally, body mass index (BMI) did reveal significant association with intra-vaginal ejaculation latency time (p-value=0.014) only, without any association with serum leptin (p-value = 0.391) among the controls. Discussion: the current study demonstrated a statistically significant association between BMI and serum leptin and IELT in the patients with lifelong premature ejaculation. Additionally, the results revealed a statistically significant association between BMI and IELT in the controls without any association with the serum leptin. Conclusion: the current study highlights the role of both body mass index and serum leptin as potential risk factors in patients with lifelong premature ejaculation. Eventually, future studies are required to duplicate this interesting association between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation.
{"title":"Study of the Role of Body Mass Index and Serum Leptin as Potential Risk Factors in Patients with Lifelong Premature Ejaculation","authors":"T. Tawfik, M. Aref, S. G. Din, Mohamed Abd El Mawgood, A. Khattab","doi":"10.21608/HA.2017.1571.1013","DOIUrl":"https://doi.org/10.21608/HA.2017.1571.1013","url":null,"abstract":"Introduction: several studies demonstrated the potential role of serum leptin in patients with premature ejaculation. Aim: we aimed in this study to evaluate the correlation between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation and healthy controls. Patients and Methods: this study was carried out on 80 consecutive patients and controls. Body mass index was measured in the patients and the controls. Serum leptin was measured in both groups at the end of the study. Additionally, the patients and the controls were asked to measure intra vaginal ejaculation latency time (IELT) by stop watch handled by their wives for 2 successive months. Results: our prospective analysis revealed a highly significant association between body mass index and serum leptin and intra-vaginal ejaculation latency time among the cases (p-value < 0.001, <0.001 respectively). Additionally, body mass index (BMI) did reveal significant association with intra-vaginal ejaculation latency time (p-value=0.014) only, without any association with serum leptin (p-value = 0.391) among the controls. Discussion: the current study demonstrated a statistically significant association between BMI and serum leptin and IELT in the patients with lifelong premature ejaculation. Additionally, the results revealed a statistically significant association between BMI and IELT in the controls without any association with the serum leptin. Conclusion: the current study highlights the role of both body mass index and serum leptin as potential risk factors in patients with lifelong premature ejaculation. Eventually, future studies are required to duplicate this interesting association between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"33 2 1","pages":"105-110"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72986261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-09-01DOI: 10.21608/HA.2017.1201.1008
A. Kandil, E. Galal, Amina M. Shawqy
Background : Female Sexual Dysfunction (FSD) is a disturbance or dysfunction in the process of desire, arousal or orgasm which can be a symptom of a biological condition, a psychological problem or an interpersonal issue or a combination of these factors. Female Sexual Dysfunction is a multi-causal and a multi-dimensional medical problem that adversely affects physical health & emotional wellbeing. Also impaired sexual function has damaging effects on the self esteem, sense of wholeness and interpersonal relationships of women. It is often emotionally distressing and might lead to familial discord and divorce, and reproduction is also affected. Sildenafil is selective type 5 phosphodiesterase (PDE5) inhibitors , taken orally and effective for men with erectile dysfunction. Previous studies suggested that sildenafil, which acts by inhibiting cyclic GMP specific PDE5, may improve the sexual health of women affected by sexual difficulties such as arousal disorders and may indirectly improve other aspects of sexual life. Sildenafil was effective and well tolerated in post menopausal women with sexual arousal disorder without concomitant hypoactive sexual desire disorder or contributory emotional relationship or historical abuse issues. Objective: This study aims to evaluate the effect of sildenafil citrate on female sexual dysfunction. Subjects and Methods: The study was conducted in Dermatology,Venereology, and Andrology department, Faculty of Medicine, Zagazig University Hospitals during the period from April 2015 to August 2016. Twenty six married female patients were included in this study. Patients were divided into two groups. Group 1 contains thirteen patients took 50mg sildenafil on demand and group 2 contains thirteen patients took placebo. Results: There was no significant differences between the studied groups regarding the demographic data, and FSFI scors. There was significant differences between pre and post treatment of sexual dysfunction scors regarding group І. There was no significant differences in post treatment results between the two studied groups as regard sexual dysfunction except in orgasm and pain. Conclusions: Sildenafil citrate may be effective in women who couldn’t achieve orgasm and decrease pain in patients with dysparunia.
{"title":"Evaluation of the Sildenafil Effect on Female Sexual Dysfunction","authors":"A. Kandil, E. Galal, Amina M. Shawqy","doi":"10.21608/HA.2017.1201.1008","DOIUrl":"https://doi.org/10.21608/HA.2017.1201.1008","url":null,"abstract":"Background : Female Sexual Dysfunction (FSD) is a disturbance or dysfunction in the process of desire, arousal or orgasm which can be a symptom of a biological condition, a psychological problem or an interpersonal issue or a combination of these factors. Female Sexual Dysfunction is a multi-causal and a multi-dimensional medical problem that adversely affects physical health & emotional wellbeing. Also impaired sexual function has damaging effects on the self esteem, sense of wholeness and interpersonal relationships of women. It is often emotionally distressing and might lead to familial discord and divorce, and reproduction is also affected. Sildenafil is selective type 5 phosphodiesterase (PDE5) inhibitors , taken orally and effective for men with erectile dysfunction. Previous studies suggested that sildenafil, which acts by inhibiting cyclic GMP specific PDE5, may improve the sexual health of women affected by sexual difficulties such as arousal disorders and may indirectly improve other aspects of sexual life. Sildenafil was effective and well tolerated in post menopausal women with sexual arousal disorder without concomitant hypoactive sexual desire disorder or contributory emotional relationship or historical abuse issues. Objective: This study aims to evaluate the effect of sildenafil citrate on female sexual dysfunction. Subjects and Methods: The study was conducted in Dermatology,Venereology, and Andrology department, Faculty of Medicine, Zagazig University Hospitals during the period from April 2015 to August 2016. Twenty six married female patients were included in this study. Patients were divided into two groups. Group 1 contains thirteen patients took 50mg sildenafil on demand and group 2 contains thirteen patients took placebo. Results: There was no significant differences between the studied groups regarding the demographic data, and FSFI scors. There was significant differences between pre and post treatment of sexual dysfunction scors regarding group І. There was no significant differences in post treatment results between the two studied groups as regard sexual dysfunction except in orgasm and pain. Conclusions: Sildenafil citrate may be effective in women who couldn’t achieve orgasm and decrease pain in patients with dysparunia.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"12 1","pages":"84-91"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74152002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To evaluate evaluation of the erectile function and mood changes in male patients with Hansen’s disease (HD). Methods: this study was conducted on fForty males (40) confirmed patients with Hansen's disease were enrolled in this research., theAll patients were subjected to the underwent the following: full Hhistory taking, International index of erectile function (IIEF-5), Beck anxiety scale and Beck depression scale. Results: About 77.5% of our patients had erectile dysfunction, and 87.5% of patients showed anxiety disorders. while While 52.5% of patients showed depressive disorders and, 27.5% of patients had abnormal free testosterone levels. There was A high negative significant correlation revealed between IIEF-5 score and deformity grading, but with there was no significant association between duration or type of leprosy and psychiatric disorders. The results showed significant negative correlation between IIEF-5 and Beck depression inventory. But no statistical significant difference regarding free testosterone level (p-value=0.109) was found between erectile dysfunction (ED) group and non ED group. Conclusion: Erectile dysfunction, anxiety and depression are very common in among patients with Hansen's disease. and sSuch problems are related to level of deformity not to type or duration of disease and not related to testosterone level. This finding could be of key importance for the clinical practice because it could modify the current management of patients with Hansen's disease.
{"title":"Evaluation of Erectile Function and Mood Changes among Male Patients with Hansen's disease","authors":"A. Moussa, Hany H. Dessoki, G. Ahmed, M. Farag","doi":"10.21608/HA.2017.3956","DOIUrl":"https://doi.org/10.21608/HA.2017.3956","url":null,"abstract":"Purpose: To evaluate evaluation of the erectile function and mood changes in male patients with Hansen’s disease (HD). Methods: this study was conducted on fForty males (40) confirmed patients with Hansen's disease were enrolled in this research., theAll patients were subjected to the underwent the following: full Hhistory taking, International index of erectile function (IIEF-5), Beck anxiety scale and Beck depression scale. Results: About 77.5% of our patients had erectile dysfunction, and 87.5% of patients showed anxiety disorders. while While 52.5% of patients showed depressive disorders and, 27.5% of patients had abnormal free testosterone levels. There was A high negative significant correlation revealed between IIEF-5 score and deformity grading, but with there was no significant association between duration or type of leprosy and psychiatric disorders. The results showed significant negative correlation between IIEF-5 and Beck depression inventory. But no statistical significant difference regarding free testosterone level (p-value=0.109) was found between erectile dysfunction (ED) group and non ED group. Conclusion: Erectile dysfunction, anxiety and depression are very common in among patients with Hansen's disease. and sSuch problems are related to level of deformity not to type or duration of disease and not related to testosterone level. This finding could be of key importance for the clinical practice because it could modify the current management of patients with Hansen's disease.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"24 1","pages":"92-97"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80821031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Abdel-Razek, E. Elsobky, Y. Moustafa, Moustafa A. Elsaied, Shreif Refaat
ABSTRACT Purpose: To estimate the frequency and types of both chromosomal abnormalities and Azoospermia Factor (AZF) microdeletions among patients with non-obstructive azoospermia (NOA) and severe oligozoospermia (SOZ) with sperm count less than 5 million/ml. Methods: Karyotyping was performed for all 1127 patients, whereas AZF microdeletions assay was done for 811 patients including 653 NOA and 158 SOZ by multiplex polymerase chain reaction (PCR). All patients were subjected to clinical examination, scrotal duplex ultrasound and hormonal evaluations. Results: The frequency of chromosomal abnormalities was 14.4%, higher in NOA than SOZ men (22.6% versus 3.7%). Numerical chromosomal abnormalities were higher than structural type (11.8% versus 2.4%). Klinefelter syndrome (KS) represented 11.2% of the total chromosomal and 94.1% of sex chromosomal abnormalities. AZF microdeletions were higher in NOA than SOZ (6.1% versus 3.16%). AZFc microdeletions represented the most frequent finding: 31/45 (68.9%), followed by AZFbc: 7/45(15.6%), AZFb: 4/45 (8.8%) and AZFa: 3/45 (6.7%). All patients with AZFa (3), AZFb (4) and AZFbc (7) deletions were NOA, while 26/31(83.87%) with isolated AZFc deletion were NOA and 5/31(16.13%) were SOZ. Conclusion: In according to the results shown, we emphasize the importance of karyotyping and AZF microdeletions analysis in such groups. Counseling for such patients before ARTs is warranted to decrease the risk of transmitting genetic abnormalities to off spring.
【摘要】目的:评估精子数量小于500万/ml的非阻塞性无精子症(NOA)和严重少精子症(SOZ)患者染色体异常和无精子症因子(AZF)微缺失的频率和类型。方法:对1127例患者进行核型分析，对811例患者进行AZF微缺失检测，其中NOA患者653例，SOZ患者158例。所有患者均接受临床检查、阴囊双工超声及激素评估。结果:NOA组染色体异常发生率为14.4%，高于SOZ组(22.6%比3.7%)。数值型染色体异常高于结构型(11.8%比2.4%)。Klinefelter综合征(KS)占总染色体的11.2%，占性染色体异常的94.1%。NOA组AZF微缺失高于SOZ组(6.1% vs . 3.16%)。AZFc微缺失最多，为31/45(68.9%)，其次是AZFbc: 7/45(15.6%)、AZFb: 4/45(8.8%)和AZFa: 3/45(6.7%)。AZFa(3)、AZFb(4)和AZFbc(7)缺失的患者均为NOA，而AZFc缺失的26/31(83.87%)为NOA, 5/31(16.13%)为SOZ。结论:根据上述结果，我们强调对这类人群进行核型分析和AZF微缺失分析的重要性。在进行抗逆转录病毒治疗之前，对这些患者进行咨询是有必要的，以减少遗传异常传给后代的风险。
{"title":"The Frequency of Chromosomal Abnormalities and Y Chromosome Microdeletions in Infertile Non-Obstructive Azoospermic and Severe Oligozoospermic Males","authors":"M. Abdel-Razek, E. Elsobky, Y. Moustafa, Moustafa A. Elsaied, Shreif Refaat","doi":"10.21608/HA.2017.3916","DOIUrl":"https://doi.org/10.21608/HA.2017.3916","url":null,"abstract":"ABSTRACT Purpose: To estimate the frequency and types of both chromosomal abnormalities and Azoospermia Factor (AZF) microdeletions among patients with non-obstructive azoospermia (NOA) and severe oligozoospermia (SOZ) with sperm count less than 5 million/ml. Methods: Karyotyping was performed for all 1127 patients, whereas AZF microdeletions assay was done for 811 patients including 653 NOA and 158 SOZ by multiplex polymerase chain reaction (PCR). All patients were subjected to clinical examination, scrotal duplex ultrasound and hormonal evaluations. Results: The frequency of chromosomal abnormalities was 14.4%, higher in NOA than SOZ men (22.6% versus 3.7%). Numerical chromosomal abnormalities were higher than structural type (11.8% versus 2.4%). Klinefelter syndrome (KS) represented 11.2% of the total chromosomal and 94.1% of sex chromosomal abnormalities. AZF microdeletions were higher in NOA than SOZ (6.1% versus 3.16%). AZFc microdeletions represented the most frequent finding: 31/45 (68.9%), followed by AZFbc: 7/45(15.6%), AZFb: 4/45 (8.8%) and AZFa: 3/45 (6.7%). All patients with AZFa (3), AZFb (4) and AZFbc (7) deletions were NOA, while 26/31(83.87%) with isolated AZFc deletion were NOA and 5/31(16.13%) were SOZ. Conclusion: In according to the results shown, we emphasize the importance of karyotyping and AZF microdeletions analysis in such groups. Counseling for such patients before ARTs is warranted to decrease the risk of transmitting genetic abnormalities to off spring.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"27 1","pages":"36-48"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82277630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Abdel-Razek, E. Elsobky, Y. Moustafa, Moustafa A. Elsaied, Shreif Refaat
Purpose: The current study was conducted to obtain information about how a sample of Egyptian women and their husbands look at their own breasts, other women's breasts, and the sexual function of breast during intercourse. Method: Self-report questionnaire, designed by the investigators. It included 303 married women with an age range of 18-48 years. Aim: It aimed to obtain information about demography, characters of participants own breast as well as other women's breasts and also the views of their husbands.Results: The most common shape was "Full on top breast" with reddish brown areolas. The commonest bra size was medium. Most participants thought that large breasts are uncomfortable and only (11.55%) of them would like to have a breast augmentation surgery. "Full on top & bottom" breast shape was the preferred shape. Most participants said that breast size does affect female attractiveness. A majority of responders said that their husbands were satisfied with the size and shape of their breasts. Participants would like their husbands to stimulate their breasts during coitus orally and manually. The ability to reach orgasm by breast stimulation only during coitus was reported by (15.51%) of participants.Conclusion: The significance of female breasts as a sexual organ must be emphasized especially to the male partner. Some women can reach orgasm by the mere stimulation of their breasts. The study outlined the importance of oral and manual stimulation of breast during foreplay.
{"title":"Characters and Significance of Female Breasts in Relation to Female Sexuailty","authors":"M. Abdel-Razek, E. Elsobky, Y. Moustafa, Moustafa A. Elsaied, Shreif Refaat","doi":"10.21608/HA.2017.3918","DOIUrl":"https://doi.org/10.21608/HA.2017.3918","url":null,"abstract":"Purpose: The current study was conducted to obtain information about how a sample of Egyptian women and their husbands look at their own breasts, other women's breasts, and the sexual function of breast during intercourse. Method: Self-report questionnaire, designed by the investigators. It included 303 married women with an age range of 18-48 years. Aim: It aimed to obtain information about demography, characters of participants own breast as well as other women's breasts and also the views of their husbands.Results: The most common shape was \"Full on top breast\" with reddish brown areolas. The commonest bra size was medium. Most participants thought that large breasts are uncomfortable and only (11.55%) of them would like to have a breast augmentation surgery. \"Full on top & bottom\" breast shape was the preferred shape. Most participants said that breast size does affect female attractiveness. A majority of responders said that their husbands were satisfied with the size and shape of their breasts. Participants would like their husbands to stimulate their breasts during coitus orally and manually. The ability to reach orgasm by breast stimulation only during coitus was reported by (15.51%) of participants.Conclusion: The significance of female breasts as a sexual organ must be emphasized especially to the male partner. Some women can reach orgasm by the mere stimulation of their breasts. The study outlined the importance of oral and manual stimulation of breast during foreplay.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"04 1","pages":"50-57"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80129314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-01DOI: 10.21608/HA.2017.1228.1007
I. Younis, Alliaa E. Daifulla, S. A. Raouf
it can be used as an indicator of fertility and can be used as method of family planning. In unmarried persons it can be an indicator about the risk of having a sexually transmissible infection. Coital frequency varies in different cultures and socioeconomic standards. The current study was carried out to bridge the knowledge gap about coital frequency in a group of Egyptian married women. Factors affecting this frequency will be also looked for.Patients and Methods: The Participants of this cross-sectional study were 306 married women attending the outpatient clinic of Benha University Hospital (for reasons other than sexual councelling). A self-report questionnaire designed by the investigators was used.Results: The most common coital frequency was 2-3 times/week (64.05%). This frequency was suitable for 78.43% of participants. Husband's desire was the most important determinant of coital frequency (89.87%). The most common cause of low coital frequency was unavailability of husband (56.86%). Problems within the family (57.19%) or with the husband (82.03%) negatively affect coital frequency. Coital frequency declines with aging and long duration of marriage.Conclusion: The most common coital frequency was 2-3 times / week followed by once/ month. Advance in age and long duration of marriage were associated with a low coital frequency. Other factors affecting coital frequency were husband's unavailability , husband's ill health, husband's sexual desire, presence or absence of problems with husband or within the family.
{"title":"Coital Frequency in a Sample of Egyptian Women","authors":"I. Younis, Alliaa E. Daifulla, S. A. Raouf","doi":"10.21608/HA.2017.1228.1007","DOIUrl":"https://doi.org/10.21608/HA.2017.1228.1007","url":null,"abstract":"it can be used as an indicator of fertility and can be used as method of family planning. In unmarried persons it can be an indicator about the risk of having a sexually transmissible infection. Coital frequency varies in different cultures and socioeconomic standards. The current study was carried out to bridge the knowledge gap about coital frequency in a group of Egyptian married women. Factors affecting this frequency will be also looked for.Patients and Methods: The Participants of this cross-sectional study were 306 married women attending the outpatient clinic of Benha University Hospital (for reasons other than sexual councelling). A self-report questionnaire designed by the investigators was used.Results: The most common coital frequency was 2-3 times/week (64.05%). This frequency was suitable for 78.43% of participants. Husband's desire was the most important determinant of coital frequency (89.87%). The most common cause of low coital frequency was unavailability of husband (56.86%). Problems within the family (57.19%) or with the husband (82.03%) negatively affect coital frequency. Coital frequency declines with aging and long duration of marriage.Conclusion: The most common coital frequency was 2-3 times / week followed by once/ month. Advance in age and long duration of marriage were associated with a low coital frequency. Other factors affecting coital frequency were husband's unavailability , husband's ill health, husband's sexual desire, presence or absence of problems with husband or within the family.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"200 1","pages":"73-83"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77212946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with genital warts (GWs), worried about the indefinite timeline and perspectives of recovery, they were often depressed and had low self-esteem. The patients’ self-image as well as their social lives were affected by the stigmatization caused by the disease. Patients found it difficult to detach themselves from their GWs because of the repeated treatments and the negative effects on their sex lives[1, 2]. Female sexual dysfunction (FSD) is defined as disorders of sexual desire, arousal, orgasm, and sexual pain, which lead to personal distress[3]. The patients suffering from GWs described themselves as ‘impure, repulsive and sexually unattractive’ and seriously questioned how others might find them attractive when they did not even like themselves. Problems often arose in existing relationships because of worries about the source of the infection or a lack of sexual desire4.Their libido is low, their sexual initiative is reduced, and pleasure is often lost during intercourse because of awareness of the warts and fear of transmitting the disease[5].
患有生殖器疣(GWs)的患者，担心不确定的康复时间和前景，他们经常感到沮丧和自卑。患者的自我形象和社会生活都受到疾病引起的污名化的影响。由于反复治疗和对性生活的负面影响，患者很难从GWs中脱离出来[1,2]。女性性功能障碍(Female sexual dysfunction, FSD)被定义为性欲、性唤起、性高潮和性疼痛紊乱，导致个人痛苦[3]。患有GWs的患者将自己描述为“不纯洁、令人反感、在性方面没有吸引力”，并严重质疑，当他们甚至不喜欢自己的时候，别人怎么会觉得他们有吸引力。由于担心感染源或缺乏性欲，在现有的关系中经常出现问题。他们的性欲低下，性主动性降低，由于意识到疣和害怕传播疾病，在性交过程中往往失去快感[5]。
{"title":"Effect of Genital Warts on Female Sexual Function and Quality of Life: An Egyptian Study","authors":"F. El-Esawy, H. Ahmed","doi":"10.21608/HA.2017.3919","DOIUrl":"https://doi.org/10.21608/HA.2017.3919","url":null,"abstract":"Patients with genital warts (GWs), worried about the indefinite timeline and perspectives of recovery, they were often depressed and had low self-esteem. The patients’ self-image as well as their social lives were affected by the stigmatization caused by the disease. Patients found it difficult to detach themselves from their GWs because of the repeated treatments and the negative effects on their sex lives[1, 2]. Female sexual dysfunction (FSD) is defined as disorders of sexual desire, arousal, orgasm, and sexual pain, which lead to personal distress[3]. The patients suffering from GWs described themselves as ‘impure, repulsive and sexually unattractive’ and seriously questioned how others might find them attractive when they did not even like themselves. Problems often arose in existing relationships because of worries about the source of the infection or a lack of sexual desire4.Their libido is low, their sexual initiative is reduced, and pleasure is often lost during intercourse because of awareness of the warts and fear of transmitting the disease[5].","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"5 1","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82459963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-01DOI: 10.21608/HA.2017.1172.1005
S. Hewedy, GhadaS. Hassan, Rana M. Abo El Enein, M. Saad
Background: Cigarette smoking is the largest preventable risk factor for morbidity and mortality in developed countries. It negatively affects male reproduction and fertility. Sperm DNA damage is one of the possible incriminating causes of diminishing fertility potential in smokers as there was a strong evidence of a link between oxidative DNA damage and the chronic complications of smoking. This has potential implications for their reproductive health, particularly given the association between sperm DNA damage and infertility, miscarriage in pregnancies fathered by these men, childhood disease. Aim: The aim of this work was to assess the integrity of sperm DNA in infertile smoker patients. Patients and methods: Sperm DNA damage was assessed using flow-cytometry in 30 infertile smoker male patients and 1 5-age matched healthy non-smoker fertile males as a control group. Results: There was an increase in the DNA fragmentation index (DFI) in smokers when compared with controls. There was a significant positive correlation between DFI with the age of patients, smoking index and duration of smoking. A significant positive correlation between DFI and sperm morphology (abnormal forms %) was found. On the other hand, there was a negative correlation between the DFI and other seminal parameters including semen volume (ml), sperm count (millions/ml) and sperm motility (active progressive%, first hour). Conclusion: This study suggested that smoking can cause sperm DNA damage that affects the quality of the ejaculated spermatozoa and their fertility potential and pregnancy outcome.
{"title":"Sperm DNA Damage In Smokers","authors":"S. Hewedy, GhadaS. Hassan, Rana M. Abo El Enein, M. Saad","doi":"10.21608/HA.2017.1172.1005","DOIUrl":"https://doi.org/10.21608/HA.2017.1172.1005","url":null,"abstract":"Background: Cigarette smoking is the largest preventable risk factor for morbidity and mortality in developed countries. It negatively affects male reproduction and fertility. Sperm DNA damage is one of the possible incriminating causes of diminishing fertility potential in smokers as there was a strong evidence of a link between oxidative DNA damage and the chronic complications of smoking. This has potential implications for their reproductive health, particularly given the association between sperm DNA damage and infertility, miscarriage in pregnancies fathered by these men, childhood disease. Aim: The aim of this work was to assess the integrity of sperm DNA in infertile smoker patients. Patients and methods: Sperm DNA damage was assessed using flow-cytometry in 30 infertile smoker male patients and 1 5-age matched healthy non-smoker fertile males as a control group. Results: There was an increase in the DNA fragmentation index (DFI) in smokers when compared with controls. There was a significant positive correlation between DFI with the age of patients, smoking index and duration of smoking. A significant positive correlation between DFI and sperm morphology (abnormal forms %) was found. On the other hand, there was a negative correlation between the DFI and other seminal parameters including semen volume (ml), sperm count (millions/ml) and sperm motility (active progressive%, first hour). Conclusion: This study suggested that smoking can cause sperm DNA damage that affects the quality of the ejaculated spermatozoa and their fertility potential and pregnancy outcome.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"42 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91175931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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