Pub Date : 2021-04-01DOI: 10.21608/ha.2021.53910.1074
I. Younis, M. Ibrahim, R. Ashraf, O. Salam
Background: Aging has a powerful impact on the quality of life in general and probably on sexual functioning. Aim: This study aimed to evaluate the impact of aging on various aspects of female sexuality.Patients and Methods: One hundred and fifty women aged 60 years or older were included in this study. They were all married and free from diseases interfering with sexual activity. The tool used was a self-report questionnaire that included 29 items designed by the investigators. The privacy and anonymity of participants were ensured.Results: Coital frequency decreased with aging; 64.3% of women aged 70–74 years reported no coitus compared with 16.7% of women aged 60–64 years. The frequency of spontaneous sexual desire also decreased with aging; 40% of women aged 70–74 years reported that spontaneous sexual desire has become rare or almost never occurs compared with14.7% of women aged 60–64 years. With aging, lubrication became difficult; 60% of women aged 70–74 years find difficulty in lubrication in more than 50% of sexual encounters compared with25% of women aged 65–69 years and 26.7% of women aged 60–64 years. Dyspareunia and anorgasmia were reported by 100% of women aged 70–74 years.Conclusion: All aspects related to sexual activity declined with aging. Dyspareunia and inability to orgasm are the main complaints in older women.
{"title":"Life may not begin after 60 : Sexuality in women after the age of 60","authors":"I. Younis, M. Ibrahim, R. Ashraf, O. Salam","doi":"10.21608/ha.2021.53910.1074","DOIUrl":"https://doi.org/10.21608/ha.2021.53910.1074","url":null,"abstract":"Background: Aging has a powerful impact on the quality of life in general and probably on sexual functioning. \u0000Aim: This study aimed to evaluate the impact of aging on various aspects of female sexuality.Patients and Methods: One hundred and fifty women aged 60 years or older were included in this study. They were all married and free from diseases interfering with sexual activity. The tool used was a self-report questionnaire that included 29 items designed by the investigators. The privacy and anonymity of participants were ensured.Results: Coital frequency decreased with aging; 64.3% of women aged 70–74 years reported no coitus compared with 16.7% of women aged 60–64 years. The frequency of spontaneous sexual desire also decreased with aging; 40% of women aged 70–74 years reported that spontaneous sexual desire has become rare or almost never occurs compared with14.7% of women aged 60–64 years. With aging, lubrication became difficult; 60% of women aged 70–74 years find difficulty in lubrication in more than 50% of sexual encounters compared with25% of women aged 65–69 years and 26.7% of women aged 60–64 years. Dyspareunia and anorgasmia were reported by 100% of women aged 70–74 years.Conclusion: All aspects related to sexual activity declined with aging. Dyspareunia and inability to orgasm are the main complaints in older women.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74983983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.21608/ha.2021.79815.1076
A. Abdel-latif, dalia elnilly, nouran abo khedr, Walid Alamiri
Background: Interleukin-17 (IL-17) is a proinflammatory cytokine that is involved in the pathogenesis of several autoimmune and inflammatory diseases. Inflammation of the testis and male-reproductive tracts may lead to male infertility. Objective: To assess seminal plasma IL-17 in infertile male patients and to evaluate its relation to the different seminal parameters. Patients and Methods: Fifty male patients with primary infertility were included in addition to 20 age-matched healthy fertile males as controls. The semen was analyzed half an hour after the ejaculation according to the WHO criteria, including sperm count, morphology, motility, viability, and leukocytecount. Seminal plasma levels of IL-17 were measured using the ELISA technique. Results: The mean seminal plasma level of IL-17 was significantly higher in infertile patients (2.42±2.43ng/l) than in controls (0.28±0.66ng/l). Also, the mean seminal plasma IL-17 level was significantly higher in patients with abnormal progressive sperm motility (4.0±2.73ng/l) than patients with normal progressive sperm motility (2.07±2.26ng/l). Conclusion: IL-17 may play an important role in the pathogenesis of male infertility associated with inflammation and infection of the testis and male genital tracts and it could be a good therapeutic target in those cases, but further studies are needed to determine the exact pathogenic role of IL-17 in male infertility.
{"title":"Evaluation of seminal plasma interleukin 17 in infertile males","authors":"A. Abdel-latif, dalia elnilly, nouran abo khedr, Walid Alamiri","doi":"10.21608/ha.2021.79815.1076","DOIUrl":"https://doi.org/10.21608/ha.2021.79815.1076","url":null,"abstract":"Background: Interleukin-17 (IL-17) is a proinflammatory cytokine that is involved in the pathogenesis of several autoimmune and inflammatory diseases. Inflammation of the testis and male-reproductive tracts may lead to male infertility. Objective: To assess seminal plasma IL-17 in infertile male patients and to evaluate its relation to the different seminal parameters. Patients and Methods: Fifty male patients with primary infertility were included in addition to 20 age-matched healthy fertile males as controls. The semen was analyzed half an hour after the ejaculation according to the WHO criteria, including sperm count, morphology, motility, viability, and leukocytecount. Seminal plasma levels of IL-17 were measured using the ELISA technique. Results: The mean seminal plasma level of IL-17 was significantly higher in infertile patients (2.42±2.43ng/l) than in controls (0.28±0.66ng/l). Also, the mean seminal plasma IL-17 level was significantly higher in patients with abnormal progressive sperm motility (4.0±2.73ng/l) than patients with normal progressive sperm motility (2.07±2.26ng/l). Conclusion: IL-17 may play an important role in the pathogenesis of male infertility associated with inflammation and infection of the testis and male genital tracts and it could be a good therapeutic target in those cases, but further studies are needed to determine the exact pathogenic role of IL-17 in male infertility.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81292509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.21608/ha.2021.88836.1078
I. Younis, Hend Abdalla, Ghada M Shams
Background: Since antiquity, people were looking for specific foods in order to improve their sexual performance. Although food may have an obvious effect on sexuality in both men and women, its effect on female sexual function is usually underestimated. Objective: The current study aimed to evaluate the impact of food on various aspects of sexuality in women. Patients and Methods: This cross-sectional study was carried out on 300 married women aged 20–50+ years having a regular sexual relation and eating different types of foods. We used a self-report questionnaire designed by the investigators. The questionnaire consisted of 21 questions that covered different aspects of female sexuality and its relation to food. Results: Most of the participants (63%) were in the age group of 30–39 years. The commonest coital frequency was —two to three times per week, which was suitable for 45.7% of the studied women. On the other hand, spontaneous desire was reported by 43% of women to occur —two to three times per week. Among our sample, 50.3% were exposed to female genital mutilation/cutting. Regarding sexual satisfaction, 47.3% reported being moderately satisfied and 38.3% were very satisfied and almost one-third of women (32.3%) can reach orgasm in more than half the times of sexual encounters. Among participants, 85% consider that the positive effects of food were increasing libido, increasing orgasm (11%), and prolonging the time of lubrication (4%). On the other hand, oils were found to decrease libido (31.8%) and have a negative effect on orgasm (36.4), while white meat was the commonest food to decrease lubrication (50%). Seafood was the most common type of food that improved husband’s sexual activity (78%) followed by nuts (25.3%). Conclusion: Our women sample believes that some kinds of food can positively or negatively affect their sexuality as well as sexual performance of their husbands.
{"title":"Can food influence female sexual functions? Views of a sample of married Egyptian women","authors":"I. Younis, Hend Abdalla, Ghada M Shams","doi":"10.21608/ha.2021.88836.1078","DOIUrl":"https://doi.org/10.21608/ha.2021.88836.1078","url":null,"abstract":"Background: Since antiquity, people were looking for specific foods in order to improve their sexual performance. Although food may have an obvious effect on sexuality in both men and women, its effect on female sexual function is usually underestimated. Objective: The current study aimed to evaluate the impact of food on various aspects of sexuality in women. Patients and Methods: This cross-sectional study was carried out on 300 married women aged 20–50+ years having a regular sexual relation and eating different types of foods. We used a self-report questionnaire designed by the investigators. The questionnaire consisted of 21 questions that covered different aspects of female sexuality and its relation to food. Results: Most of the participants (63%) were in the age group of 30–39 years. The commonest coital frequency was —two to three times per week, which was suitable for 45.7% of the studied women. On the other hand, spontaneous desire was reported by 43% of women to occur —two to three times per week. Among our sample, 50.3% were exposed to female genital mutilation/cutting. Regarding sexual satisfaction, 47.3% reported being moderately satisfied and 38.3% were very satisfied and almost one-third of women (32.3%) can reach orgasm in more than half the times of sexual encounters. Among participants, 85% consider that the positive effects of food were increasing libido, increasing orgasm (11%), and prolonging the time of lubrication (4%). On the other hand, oils were found to decrease libido (31.8%) and have a negative effect on orgasm (36.4), while white meat was the commonest food to decrease lubrication (50%). Seafood was the most common type of food that improved husband’s sexual activity (78%) followed by nuts (25.3%). Conclusion: Our women sample believes that some kinds of food can positively or negatively affect their sexuality as well as sexual performance of their husbands.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81339765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.21608/HA.2020.37010.1066
M. Eyada, Rashad M. Mostafa, S. Mahgoub, M. Azab
Background: Acne vulgaris (AV) is a common dermatological problem that affects males and females in the adolescent period and early adulthood. Isotretinoin is the treatment of choice for moderate to severe cases of AV, as it provides complete cure with minimal scarring. Males receiving isotretinoin are always concerned about its adverse effects, especially on their fertility potential. Objective: To study the effect of systemic isotretinoin on semen parameters and sperm ultrastructure of male patients treated for AV. Patients and Methods: This study was carried out on 40 male patients with resistant AV presented to the Dermatology Clinic, Suez Canal University Hospital. A total cumulative dose of 120 mg/kg of systemic isotretinoin was given to all patients over a period of 6 months. Computer-assisted semen analysis and sperm ultrastructure assay using transmission electron microscopy were done for all patients before and after the course of treatment. Results: After the course of systemic isotretinoin, a statistically significant increase in sperm concentration (million/ml), progressive sperm motility %, and morphologically normal sperms % was observed. By transmission electron microscopy, all sperm ultrastructural parameters and sperm structure dimensions were not significantly changed after isotretinoin use. Conclusion: Systemic isotretinoin in AV is a safe modality of treatment with no harmful adverse effects on semen parameters, sperm morphology, or sperm ultrastructure after 6 months of use.
{"title":"Effect of systemic isotretinoin on semen parameters and sperm ultrastructure in male patients treated for acne vulgaris : An electron microscope study","authors":"M. Eyada, Rashad M. Mostafa, S. Mahgoub, M. Azab","doi":"10.21608/HA.2020.37010.1066","DOIUrl":"https://doi.org/10.21608/HA.2020.37010.1066","url":null,"abstract":"Background: Acne vulgaris (AV) is a common dermatological problem that affects males and females in the adolescent period and early adulthood. Isotretinoin is the treatment of choice for moderate to severe cases of AV, as it provides complete cure with minimal scarring. Males receiving isotretinoin are always concerned about its adverse effects, especially on their fertility potential. Objective: To study the effect of systemic isotretinoin on semen parameters and sperm ultrastructure of male patients treated for AV. Patients and Methods: This study was carried out on 40 male patients with resistant AV presented to the Dermatology Clinic, Suez Canal University Hospital. A total cumulative dose of 120 mg/kg of systemic isotretinoin was given to all patients over a period of 6 months. Computer-assisted semen analysis and sperm ultrastructure assay using transmission electron microscopy were done for all patients before and after the course of treatment. Results: After the course of systemic isotretinoin, a statistically significant increase in sperm concentration (million/ml), progressive sperm motility %, and morphologically normal sperms % was observed. By transmission electron microscopy, all sperm ultrastructural parameters and sperm structure dimensions were not significantly changed after isotretinoin use. Conclusion: Systemic isotretinoin in AV is a safe modality of treatment with no harmful adverse effects on semen parameters, sperm morphology, or sperm ultrastructure after 6 months of use.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"4 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76256539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.21608/HA.2020.42280.1068
Hesham A. Nada, M. Elshabrawy, E. Hassan, M. Azab
Background: Anogenital warts are growths caused by human papilloma virus infection, which causes significant psychosocial morbidity. Intralesional immunotherapy is a promising treatment that is able to stimulate a delayed-type hypersensitivity reaction to different antigens as well as wart tissue. This treatment is suggested to increase CD4 T helper 1 lymphocyte activity to destroy human papilloma virus. Objective: To measure the level of serum soluble CD4 (sCD4) in patients with anogenital after intralesional tuberculin purified protein derivative (PPD) injection. Patients and Methods: This study was carried out as a pre–post interventional study on 49 patients with anogenital warts presented to the dermatology clinic and the andrology clinic, Suez Canal University Hospital. Each patient was injected 10U (0.2ml) of PPD intralesionally in the largest or mother wart with 2-week interval till complete cure or six injections, whichever was closer. Serum sCD4 was measured before and after injection using sandwich ELISA technique. Results: Complete clinical wart recovery was obtained in 26 (53%) patients and mostly was after the sixth session (60.4%) of injection. Mean level of serum sCD4 was significantly higher after than before PPD injection (18.47±10.4 vs. 44.48±20.67ng/ml, respectively). Serum sCD4 levels were significantly correlated to clinical response rates, as the higher the level of serum sCD4, the more the wart recovery. Conclusion: Intralesional PPD injection is a promising effective modality in the treatment of anogenital warts. CD4 cells may have a role in anogenital wart eradication by PPD injection and significantly related to clinical response rates.
{"title":"Evaluation of soluble CD4 serum levels in patients with anogenital warts treated with intralesional tuberculin injection","authors":"Hesham A. Nada, M. Elshabrawy, E. Hassan, M. Azab","doi":"10.21608/HA.2020.42280.1068","DOIUrl":"https://doi.org/10.21608/HA.2020.42280.1068","url":null,"abstract":"Background: Anogenital warts are growths caused by human papilloma virus infection, which causes significant psychosocial morbidity. Intralesional immunotherapy is a promising treatment that is able to stimulate a delayed-type hypersensitivity reaction to different antigens as well as wart tissue. This treatment is suggested to increase CD4 T helper 1 lymphocyte activity to destroy human papilloma virus. Objective: To measure the level of serum soluble CD4 (sCD4) in patients with anogenital after intralesional tuberculin purified protein derivative (PPD) injection. Patients and Methods: This study was carried out as a pre–post interventional study on 49 patients with anogenital warts presented to the dermatology clinic and the andrology clinic, Suez Canal University Hospital. Each patient was injected 10U (0.2ml) of PPD intralesionally in the largest or mother wart with 2-week interval till complete cure or six injections, whichever was closer. Serum sCD4 was measured before and after injection using sandwich ELISA technique. Results: Complete clinical wart recovery was obtained in 26 (53%) patients and mostly was after the sixth session (60.4%) of injection. Mean level of serum sCD4 was significantly higher after than before PPD injection (18.47±10.4 vs. 44.48±20.67ng/ml, respectively). Serum sCD4 levels were significantly correlated to clinical response rates, as the higher the level of serum sCD4, the more the wart recovery. Conclusion: Intralesional PPD injection is a promising effective modality in the treatment of anogenital warts. CD4 cells may have a role in anogenital wart eradication by PPD injection and significantly related to clinical response rates.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"404 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91141540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.21608/ha.2020.24179.1055
E. Kamal, Ahmed M Abdelmageed, Doaa A. Mahdy, T. Rageh, Aya Y Badran
Background: Stroke is one of the major causes of permanent disability and mortality in the aging population worldwide. Reduced libido, and poor erection and ejaculation are among common poststroke sexual dysfunctions, which is due to multiple factors, including both organic and psychosocial factors.Objective: We designed the study in order to detect the presence of erectile dysfunction (ED) among male patients with stroke using the International Index of Erectile Function (IIEF-5) and correlate the site of the lesion with the degree of ED. Also, we evaluated the serum total testosterone and prolactin levels among those patients and correlated their levels with the degree of ED using IIEF-5.Patients and Methods: Eighty male patients with ischemic cerebrovascular stroke were included in the study. The patients were diagnosed and divided according to the brain site lesion of cerebrovascular stroke into seven groups. The stroke patients completed the IIEF-5. Serum testosterone and prolactin levels were obtained and compared.Results: The mean age of the patients was 55.35±3.68 years. ED was detected in 53 patients representing 66.3% with variable degrees of severity (22.5% mild, 6.3% mild to moderate, 7.5% moderate, and 30.0% severe), while 27 (33.8%) patients had no ED. The mean testosterone level was lower than normal in basal ganglion affection and multiple areas affection only, while the mean prolactin level was higher than normal in all groups.Conclusion: ED is a common problem that may follow cerebrovascular stroke. We do recommend that counseling by a trained professional should be made part of stroke rehabilitation
{"title":"Stroke-related erectile dysfunction: Impact of the cerebrovascular stroke site on the degree of erectile dysfunction, total testosterone and prolactin levels","authors":"E. Kamal, Ahmed M Abdelmageed, Doaa A. Mahdy, T. Rageh, Aya Y Badran","doi":"10.21608/ha.2020.24179.1055","DOIUrl":"https://doi.org/10.21608/ha.2020.24179.1055","url":null,"abstract":"Background: Stroke is one of the major causes of permanent disability and mortality in the aging population worldwide. Reduced libido, and poor erection and ejaculation are among common poststroke sexual dysfunctions, which is due to multiple factors, including both organic and psychosocial factors.Objective: We designed the study in order to detect the presence of erectile dysfunction (ED) among male patients with stroke using the International Index of Erectile Function (IIEF-5) and correlate the site of the lesion with the degree of ED. Also, we evaluated the serum total testosterone and prolactin levels among those patients and correlated their levels with the degree of ED using IIEF-5.Patients and Methods: Eighty male patients with ischemic cerebrovascular stroke were included in the study. The patients were diagnosed and divided according to the brain site lesion of cerebrovascular stroke into seven groups. The stroke patients completed the IIEF-5. Serum testosterone and prolactin levels were obtained and compared.Results: The mean age of the patients was 55.35±3.68 years. ED was detected in 53 patients representing 66.3% with variable degrees of severity (22.5% mild, 6.3% mild to moderate, 7.5% moderate, and 30.0% severe), while 27 (33.8%) patients had no ED. The mean testosterone level was lower than normal in basal ganglion affection and multiple areas affection only, while the mean prolactin level was higher than normal in all groups.Conclusion: ED is a common problem that may follow cerebrovascular stroke. We do recommend that counseling by a trained professional should be made part of stroke rehabilitation","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"15 1","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86582460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.21608/ha.2020.24779.1056
S. A. El-Rahman, A. Zeid, M. Awady
Background: Although, sexual function is important in married couples’ relationship, little is known about the intersexual relationship especially after delivery.Objective: This is a cross-sectional study which aimed to assess and compare the impact of mode of delivery on sexual function of married couples and explore their sexual relationship after delivery.Patients and Methods: This is a cross-sectional study which enrolled 400 couples during the postpartum period and were equally divided according to the mode of delivery into two groups: group I (200) included women who had a cesarean section and group II (200) had women who had vaginal delivery (VD) and their husbands. Each group was equally subdivided according to the number of deliveries (multiparous=100 and nulliparous=100).Sexual functions of men and women were assessed according to the female sexual function index and international index of erectile function15 questionnaires, respectively. Results: Couples in the cesarean section group showed better sexual functions than in the VD group with a correlation between international index of erectile function and female sexual function index domains.Conclusion: VD, episiotomy, and multipara negatively affect female and male sexual domains.
{"title":"Effect of mode of delivery on couples’ sexual relationship during the postpartum period","authors":"S. A. El-Rahman, A. Zeid, M. Awady","doi":"10.21608/ha.2020.24779.1056","DOIUrl":"https://doi.org/10.21608/ha.2020.24779.1056","url":null,"abstract":"Background: Although, sexual function is important in married couples’ relationship, little is known about the intersexual relationship especially after delivery.Objective: This is a cross-sectional study which aimed to assess and compare the impact of mode of delivery on sexual function of married couples and explore their sexual relationship after delivery.Patients and Methods: This is a cross-sectional study which enrolled 400 couples during the postpartum period and were equally divided according to the mode of delivery into two groups: group I (200) included women who had a cesarean section and group II (200) had women who had vaginal delivery (VD) and their husbands. Each group was equally subdivided according to the number of deliveries (multiparous=100 and nulliparous=100).Sexual functions of men and women were assessed according to the female sexual function index and international index of erectile function15 questionnaires, respectively. Results: Couples in the cesarean section group showed better sexual functions than in the VD group with a correlation between international index of erectile function and female sexual function index domains.Conclusion: VD, episiotomy, and multipara negatively affect female and male sexual domains.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"64 1","pages":"92-98"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.21608/ha.2019.11345.1040
T. Mostafa
Introduction: Introduction of the oral phosphodiesterase isoenzyme-5 inhibitors (PDE5-Is) has revolutionized sexual medicine by affording effective treatment for erectile dysfunction. PDE5 hydrolyses cyclic GMP specifically to 5′-GMP. Since its launching, PDE5-Is have stimulated scientific interest for their impending benefits in various implications for the welfare of the human beings. Aim: To highlight the possible potential implications of PDE5-Is in women.Participants and methods: A systematic review was carried out till June 2017 based on a search of concerned articles in Medline, medical subject heading databases, Scopus, The Cochrane Library, Embase, and CINAHL databases without language restriction. Keywords used to assess that outcome and concerned associations were PDE5 inhibitors, sildenafil, tadalafil, vardenafil, avanafil, women, and females.Main outcome measures: Different implications for PDE5-Is in women.Results: Oral PDE5-Is have beneficial medical implications in women. Sexual implications include female sexual dysfunction, female sexual arousal disorder, antidepressant-associated sexual dysfunction, and affected relationship. Gynecological implications include endometrial thickness, abortion, preeclampsia, fetal growth restriction, clitoral engorgement, primary dysmenorrhea, uterine blood flow, oligohydramnios, poor ovarian response, ovarian ischemia/reperfusion, and uterine contractility. Urological implications include overactive bladder and interstitial cystitis, whereas dermatological implications include systemic sclerosis and cellulite. In addition, PDE5-Is proved to be beneficial in pulmonary arterial hypertension, coronary dysfunction, esophageal motility, and some metabolic effects.Conclusion: Oral PDE5-Is are an eye-catching therapeutic class of agents with beneficial effects for women, which could be potentially applied after well-designed clinical trials.
{"title":"PDE -5 inhibitors’ implications in women: Are they of help?","authors":"T. Mostafa","doi":"10.21608/ha.2019.11345.1040","DOIUrl":"https://doi.org/10.21608/ha.2019.11345.1040","url":null,"abstract":"Introduction: Introduction of the oral phosphodiesterase isoenzyme-5 inhibitors (PDE5-Is) has revolutionized sexual medicine by affording effective treatment for erectile dysfunction. PDE5 hydrolyses cyclic GMP specifically to 5′-GMP. Since its launching, PDE5-Is have stimulated scientific interest for their impending benefits in various implications for the welfare of the human beings. Aim: To highlight the possible potential implications of PDE5-Is in women.Participants and methods: A systematic review was carried out till June 2017 based on a search of concerned articles in Medline, medical subject heading databases, Scopus, The Cochrane Library, Embase, and CINAHL databases without language restriction. Keywords used to assess that outcome and concerned associations were PDE5 inhibitors, sildenafil, tadalafil, vardenafil, avanafil, women, and females.Main outcome measures: Different implications for PDE5-Is in women.Results: Oral PDE5-Is have beneficial medical implications in women. Sexual implications include female sexual dysfunction, female sexual arousal disorder, antidepressant-associated sexual dysfunction, and affected relationship. Gynecological implications include endometrial thickness, abortion, preeclampsia, fetal growth restriction, clitoral engorgement, primary dysmenorrhea, uterine blood flow, oligohydramnios, poor ovarian response, ovarian ischemia/reperfusion, and uterine contractility. Urological implications include overactive bladder and interstitial cystitis, whereas dermatological implications include systemic sclerosis and cellulite. In addition, PDE5-Is proved to be beneficial in pulmonary arterial hypertension, coronary dysfunction, esophageal motility, and some metabolic effects.Conclusion: Oral PDE5-Is are an eye-catching therapeutic class of agents with beneficial effects for women, which could be potentially applied after well-designed clinical trials.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"44 1","pages":"91-104"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86820350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.21608/ha.2020.26554.1058
N. Agamia, Abeer S. El Hadidy, A. Abd, A. El-Atawy, Ali F. El-Areny
Background: Erectile dysfunction (ED) has been reported to occur as an early manifestation of atherosclerosis. Fetuin-A and YKL-40, (N-termianl amino acid: tyrosine (Y), lysine (K), leucine (L) and its molecular mass 40 kDs) which are glycoproteins secreted by many cells, significantly participate in formation of vascular tissue in healthy and diseased states.Objective: This study aimed at assessment of serum fetuin-A and YKL-40 levels and the carotid intima-media thickness (CIMT) in patients with mild-moderate as well as moderate ED in comparison with control group.Patients and Methods: A total of 90 patients with ED (grade mild-moderate) and 30 healthy participants who attend the outpatient clinic of the Andrology Department, Alexandria Main University Hospital, were included in the study. Enzyme-linked immunosorbent assay was used for measuring both serum fetuin-A and serum YKL-40, and high-resolution B-mode ultrasound was used to measure the CIMT. Results: Statistically significant low fetuin-A and high YKL-40 serum levels as well as a significant increase in CIMT were detected in patients with ED compared with controls. In addition, the ED severity showed a negative and positive correlation to fetuin-A and YKL-40 serum levels, respectively, but there was no correlation to CIMT. Conclusion: fetuin-A and YKL-40 may be used as a predictor for cardiovascular risks in patients with mild to moderate ED.
{"title":"Fetuin-A and YKL-40 serum levels and carotid intima-media thickness: Could they be good predictors for mild to moderate erectile dysfunction?","authors":"N. Agamia, Abeer S. El Hadidy, A. Abd, A. El-Atawy, Ali F. El-Areny","doi":"10.21608/ha.2020.26554.1058","DOIUrl":"https://doi.org/10.21608/ha.2020.26554.1058","url":null,"abstract":"Background: Erectile dysfunction (ED) has been reported to occur as an early manifestation of atherosclerosis. Fetuin-A and YKL-40, (N-termianl amino acid: tyrosine (Y), lysine (K), leucine (L) and its molecular mass 40 kDs) which are glycoproteins secreted by many cells, significantly participate in formation of vascular tissue in healthy and diseased states.Objective: This study aimed at assessment of serum fetuin-A and YKL-40 levels and the carotid intima-media thickness (CIMT) in patients with mild-moderate as well as moderate ED in comparison with control group.Patients and Methods: A total of 90 patients with ED (grade mild-moderate) and 30 healthy participants who attend the outpatient clinic of the Andrology Department, Alexandria Main University Hospital, were included in the study. Enzyme-linked immunosorbent assay was used for measuring both serum fetuin-A and serum YKL-40, and high-resolution B-mode ultrasound was used to measure the CIMT. Results: Statistically significant low fetuin-A and high YKL-40 serum levels as well as a significant increase in CIMT were detected in patients with ED compared with controls. In addition, the ED severity showed a negative and positive correlation to fetuin-A and YKL-40 serum levels, respectively, but there was no correlation to CIMT. Conclusion: fetuin-A and YKL-40 may be used as a predictor for cardiovascular risks in patients with mild to moderate ED.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"23 1","pages":"99-107"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82141411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.21608/ha.2019.4844.1033
Kamal Abd El-Hafez, E. Fawzy, E. Kamal, S. Hassan, M. Zakaraia, R. Shehata
ABSTRACT Purpose: To evaluate the effect of chronic hepatitis B infection on semen parameters and reproductive hormones in Egyptians. Patients and methods: In this study, 104 males were included. They were classified into two groups: 73 patients with chronic hepatitis B without liver cirrhosis (group 1) and 31 healthy volunteers (group 2). Semen samples were analyzed using a computer-aided semen analyzer. Serum levels of follicle-stimulating hormone, luteinizing hormone, total testosterone, free testosterone, estradiol, prolactin, and sex hormone-binding globulin were measured by enzyme-linked immunosorbent assay. PCR was also evaluated. Liver condition was evaluated by liver function tests and abdominal sonography. Results: Semen parameters were affected in patients. There was a significant negative correlation between semen parameters (sperm count, motility, and morphology) and level of viremia. Moreover, a significant negative correlation was detected between level of viremia and serum levels of free testosterone and follicle-stimulating hormone. However, a positive correlation was noted between level of viremia and serum levels of prolactin and estradiol. Conclusion: Hepatitis B virus may have profound implications on male fertility potential.
{"title":"Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males","authors":"Kamal Abd El-Hafez, E. Fawzy, E. Kamal, S. Hassan, M. Zakaraia, R. Shehata","doi":"10.21608/ha.2019.4844.1033","DOIUrl":"https://doi.org/10.21608/ha.2019.4844.1033","url":null,"abstract":"ABSTRACT Purpose: To evaluate the effect of chronic hepatitis B infection on semen parameters and reproductive hormones in Egyptians. Patients and methods: In this study, 104 males were included. They were classified into two groups: 73 patients with chronic hepatitis B without liver cirrhosis (group 1) and 31 healthy volunteers (group 2). Semen samples were analyzed using a computer-aided semen analyzer. Serum levels of follicle-stimulating hormone, luteinizing hormone, total testosterone, free testosterone, estradiol, prolactin, and sex hormone-binding globulin were measured by enzyme-linked immunosorbent assay. PCR was also evaluated. Liver condition was evaluated by liver function tests and abdominal sonography. Results: Semen parameters were affected in patients. There was a significant negative correlation between semen parameters (sperm count, motility, and morphology) and level of viremia. Moreover, a significant negative correlation was detected between level of viremia and serum levels of free testosterone and follicle-stimulating hormone. However, a positive correlation was noted between level of viremia and serum levels of prolactin and estradiol. Conclusion: Hepatitis B virus may have profound implications on male fertility potential.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"119 1","pages":"106-109"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77460280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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