{"title":"Issue Information","authors":"","doi":"10.1111/soc4.12812","DOIUrl":"https://doi.org/10.1111/soc4.12812","url":null,"abstract":"No abstract is available for this article.","PeriodicalId":13030,"journal":{"name":"Human Psychopharmacology: Clinical and Experimental","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48542790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Issue Information","authors":"","doi":"10.1111/odi.13906","DOIUrl":"https://doi.org/10.1111/odi.13906","url":null,"abstract":"No abstract is available for this article.","PeriodicalId":13030,"journal":{"name":"Human Psychopharmacology: Clinical and Experimental","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43135879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The coronavirus disease 2019 (COVID-19) is spreading around the world. The COVID-19 vaccines may improve concerns about the pandemic. However, the roles of inactivated vaccines in older patients (aged ≥60 years) with infection of Delta variant were less studied.
Methods: We classified the older patients with infection of Delta variant into three groups based on the vaccination status: no vaccination (group A, n = 113), one dose of vaccination (group B, n = 46), and two doses of vaccination (group C, n = 22). Two inactivated COVID-19 vaccines (BBIBP-CorV or CoronaVac) were evaluated in this study. The demographic data, laboratory parameters, and clinical severity were recorded.
Results: A total of 181 older patients with infection of Delta variant were enrolled. 111 (61.3%) patients had one or more co-morbidities. The days of "turn negative" and hospital stay in Group C were lower than those in the other groups (P < 0.05). The incidences of multiple organ dysfunction syndrome (MODS), septic shock, acute respiratory distress syndrome (ARDS), acute kidney injury, and cardiac injury in Group A were higher than those in the other groups (P < 0.05). The MV-free days and ICU-free days during 28 days in Group A were also lower than those in the other groups (P < 0.05). In patients with co-morbidities, vaccinated cases had lower incidences of MODS (P = 0.015), septic shock (P = 0.015), and ARDS (P = 0.008).
Conclusions: The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant.
{"title":"The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China.","authors":"Xiao-Chun Song, Xue-Hui Zhou, Jing-Hui Cheng, Wen-Hao Zhang, Xiao Shen, Huan Xu, Shuai Nie, Ji-Lai Xiao, Fang Sun, Chang Shu, Jiu-Dong Chen, Yan Tang, Xiang Wang, Xin-Pei Sun, Jia-Kui Sun, Ping Feng, Qian-Kun Shi","doi":"10.18632/aging.204085","DOIUrl":"10.18632/aging.204085","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) is spreading around the world. The COVID-19 vaccines may improve concerns about the pandemic. However, the roles of inactivated vaccines in older patients (aged ≥60 years) with infection of Delta variant were less studied.</p><p><strong>Methods: </strong>We classified the older patients with infection of Delta variant into three groups based on the vaccination status: no vaccination (group A, <i>n</i> = 113), one dose of vaccination (group B, <i>n</i> = 46), and two doses of vaccination (group C, <i>n</i> = 22). Two inactivated COVID-19 vaccines (BBIBP-CorV or CoronaVac) were evaluated in this study. The demographic data, laboratory parameters, and clinical severity were recorded.</p><p><strong>Results: </strong>A total of 181 older patients with infection of Delta variant were enrolled. 111 (61.3%) patients had one or more co-morbidities. The days of \"turn negative\" and hospital stay in Group C were lower than those in the other groups (<i>P</i> < 0.05). The incidences of multiple organ dysfunction syndrome (MODS), septic shock, acute respiratory distress syndrome (ARDS), acute kidney injury, and cardiac injury in Group A were higher than those in the other groups (<i>P</i> < 0.05). The MV-free days and ICU-free days during 28 days in Group A were also lower than those in the other groups (<i>P</i> < 0.05). In patients with co-morbidities, vaccinated cases had lower incidences of MODS (<i>P</i> = 0.015), septic shock (<i>P</i> = 0.015), and ARDS (<i>P</i> = 0.008).</p><p><strong>Conclusions: </strong>The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant.</p>","PeriodicalId":13030,"journal":{"name":"Human Psychopharmacology: Clinical and Experimental","volume":"10 1","pages":"4211-4219"},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72796849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}