Alexander N. Larin , Anastasia A. Borovleva , Oleg P. Demidov , Elena K. Avakyan , Alexander A. Zubenko , Diana Yu. Pobedinskaya , Artem P. Ermolenko , Stepan E. Kolosov , Ivan V. Borovlev
Direct oxidative SNH alkylamination of 3‐, 5‐, 6‐, 7‐, 8‐nitroquinolines and 5‐nitroisoquinoline in an aqueous solution of an aliphatic amines gives rise to the corresponding alkylamino and dialkylamino derivatives of these nitrohetarenes. The nitro group solely dictates the regioselectivity of reactions. The antibacterial activity of some of them has been studied.
{"title":"Selective SNH Alkylamination of 3(5,6,7,8)‐Nitroquinoline and 5‐Nitroisoquinoline in an Aqueous Medium","authors":"Alexander N. Larin , Anastasia A. Borovleva , Oleg P. Demidov , Elena K. Avakyan , Alexander A. Zubenko , Diana Yu. Pobedinskaya , Artem P. Ermolenko , Stepan E. Kolosov , Ivan V. Borovlev","doi":"10.1002/ajoc.202400490","DOIUrl":"10.1002/ajoc.202400490","url":null,"abstract":"<div><div>Direct oxidative S<sub>N</sub><sup>H</sup> alkylamination of 3‐, 5‐, 6‐, 7‐, 8‐nitroquinolines and 5‐nitroisoquinoline in an aqueous solution of an aliphatic amines gives rise to the corresponding alkylamino and dialkylamino derivatives of these nitrohetarenes. The nitro group solely dictates the regioselectivity of reactions. The antibacterial activity of some of them has been studied.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":"Article e202400490"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kuan‐Te Liu , Yu‐Lin Hung , Kai‐Wun Jhang , Hung‐Chi Chen , Hung‐Li Li , Prof. Chien‐Wei Chiang
Indoles are critically important heterocyclic building blocks with broad applications in pharmaceuticals, fragrances, agrochemicals, pigments, and materials. Recent advancements have highlighted bis‐indole derivatives and oligomerized indoles as promising scaffolds for anticancer compounds and materials in organic semiconductors. Despite the challenges in forming C−C bonds in indoles, we developed a novel method combining electrochemical and cobalt complex dual catalysis to achieve regioselective C3−C3/C2−C3 coupling. Using 1‐methylindole as a model substrate, we optimized reaction conditions to achieve a 90 % yield of the tetramerized product. The method proved effective for various substituted indoles, with satisfactory yields for 6‐position substituents and poorer results for 5‐position due to steric hindrance, as confirmed by DFT calculations. The proposed mechanism involves initial C3−C3 coupling facilitated by cobalt catalysis, followed by C2−C3 coupling under electrochemical conditions, providing an efficient and environmentally benign strategy for synthesizing complex indole derivatives.
{"title":"Electrochemical/Cobalt Dual Catalysis for Regioselective Tetramerization of Indoles","authors":"Kuan‐Te Liu , Yu‐Lin Hung , Kai‐Wun Jhang , Hung‐Chi Chen , Hung‐Li Li , Prof. Chien‐Wei Chiang","doi":"10.1002/ajoc.202400526","DOIUrl":"10.1002/ajoc.202400526","url":null,"abstract":"<div><div>Indoles are critically important heterocyclic building blocks with broad applications in pharmaceuticals, fragrances, agrochemicals, pigments, and materials. Recent advancements have highlighted bis‐indole derivatives and oligomerized indoles as promising scaffolds for anticancer compounds and materials in organic semiconductors. Despite the challenges in forming C−C bonds in indoles, we developed a novel method combining electrochemical and cobalt complex dual catalysis to achieve regioselective C3−C3/C2−C3 coupling. Using 1‐methylindole as a model substrate, we optimized reaction conditions to achieve a 90 % yield of the tetramerized product. The method proved effective for various substituted indoles, with satisfactory yields for 6‐position substituents and poorer results for 5‐position due to steric hindrance, as confirmed by DFT calculations. The proposed mechanism involves initial C3−C3 coupling facilitated by cobalt catalysis, followed by C2−C3 coupling under electrochemical conditions, providing an efficient and environmentally benign strategy for synthesizing complex indole derivatives.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":"Article e202400526"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Jian Zhang , Yuxi Song , Prof. Dr. Zhenfeng Zhang , Prof. Dr. Wanbin Zhang
Asymmetric hydrogenation of enol ethers has emerged as a valuable and environmentally friendly method for the preparation of optically active cyclic and acyclic ethers, some of which have demonstrated substantial potential for application in the synthesis of valuable compounds and total synthesis of natural products. Over the past few decades, significant attention has been devoted to the use of transition‐metal catalysts, particularly those containing chiral phosphine‐phosphine, phosphine‐amine, or carbene ligands, in the hydrogenation of unfunctionalized enol ethers. In parallel, frustrated Lewis pair catalysts have also been successfully applied in this transformation, enabling the efficient production of various chiral ethers. This review highlights the momentum and most notable advances in enantioselective hydrogenation of unfunctionalized enol ethers (with only alkyl and aryl substituents on the vinyl group). Owing to ubiquitous industrial interest, the utility in the synthesis of chiral ethers and related derivatives is included.
{"title":"Advances in Asymmetric Hydrogenation of Unfunctionalized Enol Ethers","authors":"Dr. Jian Zhang , Yuxi Song , Prof. Dr. Zhenfeng Zhang , Prof. Dr. Wanbin Zhang","doi":"10.1002/ajoc.202400584","DOIUrl":"10.1002/ajoc.202400584","url":null,"abstract":"<div><div>Asymmetric hydrogenation of enol ethers has emerged as a valuable and environmentally friendly method for the preparation of optically active cyclic and acyclic ethers, some of which have demonstrated substantial potential for application in the synthesis of valuable compounds and total synthesis of natural products. Over the past few decades, significant attention has been devoted to the use of transition‐metal catalysts, particularly those containing chiral phosphine‐phosphine, phosphine‐amine, or carbene ligands, in the hydrogenation of unfunctionalized enol ethers. In parallel, frustrated Lewis pair catalysts have also been successfully applied in this transformation, enabling the efficient production of various chiral ethers. This review highlights the momentum and most notable advances in enantioselective hydrogenation of unfunctionalized enol ethers (with only alkyl and aryl substituents on the vinyl group). Owing to ubiquitous industrial interest, the utility in the synthesis of chiral ethers and related derivatives is included.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 2","pages":"Article e202400584"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The development towards C(sp3)-H functionalization of arylmethylamines has been the main attraction for synthetic organic chemists.In article number e202400427 by Vikas D. Kadu, the synthetic approaches from C-H/C-N bond functionalization of arylmethylamines/amines as a new emerging substrate are described in detail towards the synthesis of substituted benzothiazoles with insights into substrate scope and the reaction mechanistic pathway for the formation of final targeted products.
{"title":"Front Cover: Recent Advances for Synthesis of Benzothiazoles from Arylmethylamines (Asian J. Org. Chem. 1/2025)","authors":"Vikas D. Kadu","doi":"10.1002/ajoc.202580101","DOIUrl":"https://doi.org/10.1002/ajoc.202580101","url":null,"abstract":"<p>The development towards C(sp<sup>3</sup>)-<i>H</i> functionalization of arylmethylamines has been the main attraction for synthetic organic chemists.In article number e202400427 by Vikas D. Kadu, the synthetic approaches from C-H/C-N bond functionalization of arylmethylamines/amines as a new emerging substrate are described in detail towards the synthesis of substituted benzothiazoles with insights into substrate scope and the reaction mechanistic pathway for the formation of final targeted products.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajoc.202580101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143116122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aryl‐tethered o‐carboranes have attracted attention as a platform for obtaining functional solid‐state luminescent materials with stimuli‐responsiveness. To extend the versatility and applicability for advanced sensing technologies, it is essential to establish new mechanisms for regulating solid‐state luminescent properties. In this study, we demonstrate the regulation of solid‐state luminescent properties of the modified o‐carborane through photo‐induced electron transfer. We synthesized the triad based on o‐carborane modified with pyrene as a luminophore from intermolecular charge transfer and diethylaniline as a quencher. In the pristine solid state, significant emission was hardly observed due to emission quenching through photo‐induced electron transfer, while intense emission was recovered by acid vapor fuming for protonation at the diethylaniline moiety. Moreover, we confirmed that reversible changes underwent by amine vapor fuming. These results mean that solid‐state luminescent properties of o‐carborane can be controlled by the commodity photochemical process according to the molecular design.
{"title":"Design for a Solid‐State Luminescent Sensor Through Photo‐Induced Electron Transfer Based on Pyrene‐Modified o‐Carborane","authors":"Shunsuke Nishiyama , Junki Ochi , Kazuo Tanaka","doi":"10.1002/ajoc.202400513","DOIUrl":"10.1002/ajoc.202400513","url":null,"abstract":"<div><div>Aryl‐tethered <em>o</em>‐carboranes have attracted attention as a platform for obtaining functional solid‐state luminescent materials with stimuli‐responsiveness. To extend the versatility and applicability for advanced sensing technologies, it is essential to establish new mechanisms for regulating solid‐state luminescent properties. In this study, we demonstrate the regulation of solid‐state luminescent properties of the modified <em>o</em>‐carborane through photo‐induced electron transfer. We synthesized the triad based on <em>o</em>‐carborane modified with pyrene as a luminophore from intermolecular charge transfer and diethylaniline as a quencher. In the pristine solid state, significant emission was hardly observed due to emission quenching through photo‐induced electron transfer, while intense emission was recovered by acid vapor fuming for protonation at the diethylaniline moiety. Moreover, we confirmed that reversible changes underwent by amine vapor fuming. These results mean that solid‐state luminescent properties of <em>o</em>‐carborane can be controlled by the commodity photochemical process according to the molecular design.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":"Article e202400513"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed Mohideen Mohamed Haneef , Prof. Fazlurrahman Nawaz Khan
This study presents a sustainable chemical approach for the tandem synthesis of Piriqualone a sedative and anxiolytic drug and its analogues using a green protocol. The research investigates the ability of deep eutectic solvents (DESs) to act as catalysts as well as solvent in a tandem reaction involving transition metal‐free dehydrogenation and sp3 C−H bond functionalization, leading to the formation of styryl‐heterocyclic compounds (7a–p). These styryl derivatives were thoroughly characterized through spectral analysis and photophysical property evaluation. The relationship between chemical structure and AIE properties was particularly examined for compound 7n. Additionally, the experimental findings were corroborated by density functional theory (DFT) calculations. The structures of compounds 7j, 7p and 7fa were further validated through single crystal X‐ray diffraction (XRD) analysis.
{"title":"Tandem Synthesis of Piriqualone and Analogues Using Deep Eutectic Solvents: Photophysical and Theoretical Insights","authors":"Mohamed Mohideen Mohamed Haneef , Prof. Fazlurrahman Nawaz Khan","doi":"10.1002/ajoc.202400487","DOIUrl":"10.1002/ajoc.202400487","url":null,"abstract":"<div><div>This study presents a sustainable chemical approach for the tandem synthesis of Piriqualone a sedative and anxiolytic drug and its analogues using a green protocol. The research investigates the ability of deep eutectic solvents (DESs) to act as catalysts as well as solvent in a tandem reaction involving transition metal‐free dehydrogenation and <em>sp</em><sup><em>3</em></sup> C−H bond functionalization, leading to the formation of styryl‐heterocyclic compounds (7a–p). These styryl derivatives were thoroughly characterized through spectral analysis and photophysical property evaluation. The relationship between chemical structure and AIE properties was particularly examined for compound 7n. Additionally, the experimental findings were corroborated by density functional theory (DFT) calculations. The structures of compounds 7j, 7p and 7fa were further validated through single crystal X‐ray diffraction (XRD) analysis.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":"Article e202400487"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chen‐Yi Li , Yao Wang , Dan Hu , Bin Zhang , Heng Yin , Yu‐Long Li
A base promoted [3+2] cycloaddition of benzothiazolium salts with isoindigos has been developed, and a series of novel N, S‐polyheterocyclic 3, 3′ bispirooxindoles with four contiguous cycles and two spiro quaternary stereocenters have been successfully and effectively prepared in good to excellent yields (up to 99 %) under mild conditions.
{"title":"A Base Promoted [3+2] Cycloaddition of Benzothiazolium Salts with Isoindigos to Synthesis N, S‐polyheterocyclic 3, 3′ Bispirooxindoles","authors":"Chen‐Yi Li , Yao Wang , Dan Hu , Bin Zhang , Heng Yin , Yu‐Long Li","doi":"10.1002/ajoc.202400478","DOIUrl":"10.1002/ajoc.202400478","url":null,"abstract":"<div><div>A base promoted [3+2] cycloaddition of benzothiazolium salts with isoindigos has been developed, and a series of novel N, S‐polyheterocyclic 3, 3′ bispirooxindoles with four contiguous cycles and two spiro quaternary stereocenters have been successfully and effectively prepared in good to excellent yields (up to 99 %) under mild conditions.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":"Article e202400478"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sundararajan Suresh , Pari Keerthana , Fazlurrahman Nawaz Khan
An efficient and environmentally friendly one‐pot sequential synthesis of functionalized nordazepam and a benzimidazoquinazoline analogue is reported, utilizing cobalt as the metal catalyst. The reaction proceeds via either the α‐alkenylation or dehydrogenative sp3 C−H functionalization pathway. This transformation includes mild reaction conditions, operational simplicity, and good functional group tolerance. Additionally, this method is suitable for the gram‐scale synthesis of functionalized nordazepam and benzimidazoquinazoline compounds. Furthermore, the synthetic utility, photophysical properties and real‐life application of the synthesized derivatives were explored.
{"title":"Cobalt‐Catalyzed Synthesis of Functionalized Nordazepams and Benzimidazoquinazolines and Their Photophysical Properties","authors":"Sundararajan Suresh , Pari Keerthana , Fazlurrahman Nawaz Khan","doi":"10.1002/ajoc.202400455","DOIUrl":"10.1002/ajoc.202400455","url":null,"abstract":"<div><div>An efficient and environmentally friendly one‐pot sequential synthesis of functionalized nordazepam and a benzimidazoquinazoline analogue is reported, utilizing cobalt as the metal catalyst. The reaction proceeds <em>via</em> either the <em>α</em>‐alkenylation or dehydrogenative <em>sp</em><sup><em>3</em></sup> C−H functionalization pathway. This transformation includes mild reaction conditions, operational simplicity, and good functional group tolerance. Additionally, this method is suitable for the gram‐scale synthesis of functionalized nordazepam and benzimidazoquinazoline compounds. Furthermore, the synthetic utility, photophysical properties and real‐life application of the synthesized derivatives were explored.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":"Article e202400455"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rh(III)‐catalyzed spiro‐annulation of sulfoximines with maleimides leads to the diastereoselective synthesis of spirocyclic‐1,2‐benzisothiazole heterocycles is disclosed here. This strategy rapidly assembles five‐membered sulfur‐nitrogen‐containing spirocyclic molecules in one‐step. Moreover, the method is scalable and exhibits favourable diastereoselectivity, moderate functional group tolerance, and excellent site‐selectivity.
{"title":"Synthesis of Spirocyclic‐1,2‐Benzisothiazoles by Rh(III)‐Catalyzed [4+1] Annulation of Sulfoximines with Maleimides","authors":"Anil Kumar , Sudharshan Nagabhushana Reddy , Vinayak Hanchate , Kandikere Ramaiah Prabhu","doi":"10.1002/ajoc.202400537","DOIUrl":"10.1002/ajoc.202400537","url":null,"abstract":"<div><div>Rh(III)‐catalyzed spiro‐annulation of sulfoximines with maleimides leads to the diastereoselective synthesis of spirocyclic‐1,2‐benzisothiazole heterocycles is disclosed here. This strategy rapidly assembles five‐membered sulfur‐nitrogen‐containing spirocyclic molecules in one‐step. Moreover, the method is scalable and exhibits favourable diastereoselectivity, moderate functional group tolerance, and excellent site‐selectivity.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":"Article e202400537"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Yeonghun Song , Junekyoung Lee , Seonghun Kim , Prof. Dr. Seunghee Lee , Prof. Dr. Sanghee Kim
Despite the potential of non‐classical glucocorticoid response element (GRE)‐selective glucocorticoid receptor (GR) modulators in biomedical sciences, progress has not yet been made. In this study, we discovered a first‐in‐class chemical modulator that selectively suppresses the transcriptional activity of the GR in a gene with a non‐classical GRE, but not with classical GREs. The orexigenic agouti‐related peptide (Agrp)‐gene with a non‐classical GRE was chosen for this study. Similarity‐implemented virtual screening and rational modification of the structure of the initial hit compounds led to the identification of a pentacyclic natural triterpenoid, Zj7 (2‐O‐trans‐p‐coumaroylalphitolic acid). With this compound, we recently reported the verification of the orexigenic function and mechanism of action of GR in AgRP neurons. Herein, we describe the detailed discovery process leading to the identification of Zj7 and propose its molecular mode of action using molecular dynamics simulation.
{"title":"Discovery and MD Simulation of a Triterpenoid Zj7 as GR Modulator Targeting Non‐Classical GRE with Potent Anti‐Obesity Activity","authors":"Dr. Yeonghun Song , Junekyoung Lee , Seonghun Kim , Prof. Dr. Seunghee Lee , Prof. Dr. Sanghee Kim","doi":"10.1002/ajoc.202400540","DOIUrl":"10.1002/ajoc.202400540","url":null,"abstract":"<div><div>Despite the potential of non‐classical glucocorticoid response element (GRE)‐selective glucocorticoid receptor (GR) modulators in biomedical sciences, progress has not yet been made. In this study, we discovered a first‐in‐class chemical modulator that selectively suppresses the transcriptional activity of the GR in a gene with a non‐classical GRE, but not with classical GREs. The orexigenic agouti‐related peptide (<em>Agrp</em>)‐gene with a non‐classical GRE was chosen for this study. Similarity‐implemented virtual screening and rational modification of the structure of the initial hit compounds led to the identification of a pentacyclic natural triterpenoid, Zj7 (2‐<em>O‐trans‐p</em>‐coumaroylalphitolic acid). With this compound, we recently reported the verification of the orexigenic function and mechanism of action of GR in AgRP neurons. Herein, we describe the detailed discovery process leading to the identification of Zj7 and propose its molecular mode of action using molecular dynamics simulation.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 1","pages":"Article e202400540"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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