Radical cascade cyclization reactions are widely employed in the synthesis of functionalized heterocycles due to their numerous advantages. This review carefully compiles and analyzes recent advancements in the construction of 2‐functionalized thioflavones through radical cascade cyclization reactions, emphasizing their potential and versatility in generating a range of valuable thioflavone products. These strategies enable the efficient synthesis of diverse 2‐functionalized thioflavones via heat‐ or light‐promoted reactions using methylthiolated alkynones as the acceptor substrate. In this review, we aim to provide a thorough overview of the state‐of‐the‐art approaches by exploring the mechanisms and scope of these reactions, while serving as a vital reference for future research and industrial applications in thioflavones synthesis.
{"title":"Recent Applications of Radical Cascade Cyclization in the Synthesis of 2‐Functionalized Thioflavones","authors":"Jia‐Nan Chen , Yanli Yin , Fan‐Lin Zeng , Teck‐Peng Loh","doi":"10.1002/ajoc.70182","DOIUrl":"10.1002/ajoc.70182","url":null,"abstract":"<div><div>Radical cascade cyclization reactions are widely employed in the synthesis of functionalized heterocycles due to their numerous advantages. This review carefully compiles and analyzes recent advancements in the construction of 2‐functionalized thioflavones through radical cascade cyclization reactions, emphasizing their potential and versatility in generating a range of valuable thioflavone products. These strategies enable the efficient synthesis of diverse 2‐functionalized thioflavones via heat‐ or light‐promoted reactions using methylthiolated alkynones as the acceptor substrate. In this review, we aim to provide a thorough overview of the state‐of‐the‐art approaches by exploring the mechanisms and scope of these reactions, while serving as a vital reference for future research and industrial applications in thioflavones synthesis.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e70182"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A metal‐free strategy for the preparation of trifluoromethyl‐substituted tetrazoles via KI/TBHP‐mediated oxidative annulation of readily available trifluoroacetimidohydrazides (TFAIHs) and nitromethane has been disclosed. In this transformation, CH3NO2 is applied as both the inexpensive nitrogen synthon and reaction solvent, providing a straightforward access to a library of functionalized tetrazoles in moderate to good yields. Two plausible reaction pathways have been proposed on the basis of the preliminary mechanistic observations. The reaction could be scaled up to a 5 mmol scale and be applied to synthesize the key skeleton of GR205771, which is an orally active antiemetic NK1 receptor antagonist.
{"title":"Synthesis of Trifluoromethyl‐Substituted Tetrazoles via KI/TBHP‐Mediated Oxidative Annulation of Trifluoroacetimidohydrazides and Nitromethane","authors":"Jian Chen , Zijian Wang , Zhengkai Chen","doi":"10.1002/ajoc.70204","DOIUrl":"10.1002/ajoc.70204","url":null,"abstract":"<div><div>A metal‐free strategy for the preparation of trifluoromethyl‐substituted tetrazoles via KI/TBHP‐mediated oxidative annulation of readily available trifluoroacetimidohydrazides (TFAIHs) and nitromethane has been disclosed. In this transformation, CH<sub>3</sub>NO<sub>2</sub> is applied as both the inexpensive nitrogen synthon and reaction solvent, providing a straightforward access to a library of functionalized tetrazoles in moderate to good yields. Two plausible reaction pathways have been proposed on the basis of the preliminary mechanistic observations. The reaction could be scaled up to a 5 mmol scale and be applied to synthesize the key skeleton of GR205771, which is an orally active antiemetic NK<sub>1</sub> receptor antagonist.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e70204"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaoai Liu , Songyi Gao , Chao Peng , Yu Xiong , Ye Guo , Ming Lang , Shiyong Peng
Herein, we have developed a catalytic (6 + 1) annulation of diazooxindoles with hexahydropyrimidines under rhodium or copper catalysis. This strategy offers a general and efficient method for constructing pharmacologically relevant 1,4‐diazepane‐spirooxindole frameworks in moderate to excellent yields. Diverse synthetic transformations of the obtained products have also been achieved to obtain more complex and even drug‐like spirooxindoles, demonstrating the broad synthetic utility of this approach.
{"title":"Synthesis of Novel 1,4‐Diazepane‐Spirooxindole Frameworks via Catalytic (6 + 1) Annulation of Diazooxindoles with Hexahydropyrimidines","authors":"Xiaoai Liu , Songyi Gao , Chao Peng , Yu Xiong , Ye Guo , Ming Lang , Shiyong Peng","doi":"10.1002/ajoc.202500587","DOIUrl":"10.1002/ajoc.202500587","url":null,"abstract":"<div><div>Herein, we have developed a catalytic (6 + 1) annulation of diazooxindoles with hexahydropyrimidines under rhodium or copper catalysis. This strategy offers a general and efficient method for constructing pharmacologically relevant 1,4‐diazepane‐spirooxindole frameworks in moderate to excellent yields. Diverse synthetic transformations of the obtained products have also been achieved to obtain more complex and even drug‐like spirooxindoles, demonstrating the broad synthetic utility of this approach.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e00587"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Assoc. Prof. Junjiao Wang , Xiujuan Zhao , Yinzhu Wang , Yang Li , Kaijian Zhu , Na Wang , Prof. Danfeng Huang , Assoc. Prof. Ke‐Hu Wang , Prof. Yulai Hu
A novel method for synthesizing fully substituted 2‐trifluoromethylthiazoles is reported, achieving yields up to 94% via trifluoroacetic acid (TFA)‐mediated intermolecular cyclization of α‐mercapto ketones with trifluoromethyl N‐acylhydrazones under mild, open‐flask conditions. This reaction involves cleavage of the N–N bond in the acylhydrazone moiety, and efficiently constructs dual carbon‐heteroatom bonds of C─N and C─S in one step. The protocol features broad substrate scope, operational simplicity, and scalability, as demonstrated by a gram‐scale synthesis.
{"title":"Trifluoroacetic Acid‐Mediated Cyclization of α‐Mercapto Ketones with Trifluoromethyl N‐Acylhydrazones for the Synthesis of 2‐Trifluoromethylthiazole Derivatives","authors":"Assoc. Prof. Junjiao Wang , Xiujuan Zhao , Yinzhu Wang , Yang Li , Kaijian Zhu , Na Wang , Prof. Danfeng Huang , Assoc. Prof. Ke‐Hu Wang , Prof. Yulai Hu","doi":"10.1002/ajoc.70213","DOIUrl":"10.1002/ajoc.70213","url":null,"abstract":"<div><div>A novel method for synthesizing fully substituted 2‐trifluoromethylthiazoles is reported, achieving yields up to 94% via trifluoroacetic acid (TFA)‐mediated intermolecular cyclization of α‐mercapto ketones with trifluoromethyl <em>N</em>‐acylhydrazones under mild, open‐flask conditions. This reaction involves cleavage of the N–N bond in the acylhydrazone moiety, and efficiently constructs dual carbon‐heteroatom bonds of C─N and C─S in one step. The protocol features broad substrate scope, operational simplicity, and scalability, as demonstrated by a gram‐scale synthesis.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e70213"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yong Qiang Wan , Shi Lin Zhang , Yang‐Yang Zhang , Zeng Yuan Li , Xinyi Shi , Prof. John F. Gallagher , Prof. Jun Li , Prof. Pavle Mocilac
In our quest for novel An/Ln separating ligands, we have synthesized a heterocyclic precursor based on phenanthroline and identified it as 10‐azidotetrazolo[1,5‐a][1,10] phenanthroline. This asymmetric heterocyclic azide has been synthesized in four reaction steps in good yield and is well characterized via experimental methods. Thermal analysis shows that this compound is reasonably stable as an azide. The heterocycle shows fluorescent properties with a distinctive red shift of the emissions and excitation peaks. A single‐crystal XRD study shows that the molecule is planar and exhibits total molecular disorder with molecules in the crystal structure present in a major:minor conformation ratio of 0.91:0.09 and related by a 180° flip. In addition, quantum‐theoretical investigation suggests that such a product with one fused tetrazolo ring is the most stable one out of other alternatives. This molecule presents a relatively rare case of azido‐tetrazole tautomerism in 1.10‐phenanthroline.
{"title":"10‐Azidotetrazolo[1,5‐a][1,10] Phenanthroline: A Case of Azido‐tetrazole Behavior in 1,10‐Phenanthroline with Unusual Molecular Structure","authors":"Yong Qiang Wan , Shi Lin Zhang , Yang‐Yang Zhang , Zeng Yuan Li , Xinyi Shi , Prof. John F. Gallagher , Prof. Jun Li , Prof. Pavle Mocilac","doi":"10.1002/ajoc.202500592","DOIUrl":"10.1002/ajoc.202500592","url":null,"abstract":"<div><div>In our quest for novel An/Ln separating ligands, we have synthesized a heterocyclic precursor based on phenanthroline and identified it as 10‐azidotetrazolo[1,5‐a][1,10] phenanthroline. This asymmetric heterocyclic azide has been synthesized in four reaction steps in good yield and is well characterized via experimental methods. Thermal analysis shows that this compound is reasonably stable as an azide. The heterocycle shows fluorescent properties with a distinctive red shift of the emissions and excitation peaks. A single‐crystal XRD study shows that the molecule is planar and exhibits total molecular disorder with molecules in the crystal structure present in a major:minor conformation ratio of 0.91:0.09 and related by a 180° flip. In addition, quantum‐theoretical investigation suggests that such a product with one fused tetrazolo ring is the most stable one out of other alternatives. This molecule presents a relatively rare case of azido‐tetrazole tautomerism in 1.10‐phenanthroline.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e00592"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiayi Luo , Shengbiao Yang , Bing Han , Yanshuo Liu , Jincheng Li , Ran Wang , Baochuan Guan , Chunhao Yuan
4‐Alkyl coumarins and 2‐alkyl quinolines exhibit significant biological activities. Connecting these two molecular frameworks via an alkyl chain represents a promising strategy for developing novel bioactive compounds. However, research in this area remains relatively limited. Recently, a Pd(0) π‐Lewis base‐catalyzed C─C coupling strategy has emerged as an efficient method for coupling such molecules. In this study, we report a palladium‐catalyzed cascade reaction involving intramolecular cyclization and intermolecular Michael addition between allenyl benzoxazinones and 3‐aroylcoumarins. The process initiates with the Pd‐mediated formation of η2‐Pd complexes from allenyl benzoxazinones, which subsequently undergo C─C coupling with 3‐aroylcoumarins, enabling efficient access to a diverse series of 4‐(quinolin‐2‐ylmethyl)coumarin derivatives.
{"title":"Palladium‐Catalyzed Cascade Intramolecular Cyclization/Intermolecular Michael Addition Reaction of Allenyl Benzoxazinones with 3‐Aroylcoumarins","authors":"Jiayi Luo , Shengbiao Yang , Bing Han , Yanshuo Liu , Jincheng Li , Ran Wang , Baochuan Guan , Chunhao Yuan","doi":"10.1002/ajoc.70202","DOIUrl":"10.1002/ajoc.70202","url":null,"abstract":"<div><div>4‐Alkyl coumarins and 2‐alkyl quinolines exhibit significant biological activities. Connecting these two molecular frameworks via an alkyl chain represents a promising strategy for developing novel bioactive compounds. However, research in this area remains relatively limited. Recently, a Pd(0) π‐Lewis base‐catalyzed C─C coupling strategy has emerged as an efficient method for coupling such molecules. In this study, we report a palladium‐catalyzed cascade reaction involving intramolecular cyclization and intermolecular Michael addition between allenyl benzoxazinones and 3‐aroylcoumarins. The process initiates with the Pd‐mediated formation of η<sup>2</sup>‐Pd complexes from allenyl benzoxazinones, which subsequently undergo C─C coupling with 3‐aroylcoumarins, enabling efficient access to a diverse series of 4‐(quinolin‐2‐ylmethyl)coumarin derivatives.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e70202"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ester synthesis has traditionally depended on expensive metal catalysts and harsh reaction conditions. Despite the widespread use of these methods, challenges remain in the efficient synthesis of substituted esters. Here, we present a new metal‐free esterification method, in which hydroxylamine‐O‐sulfonic acid (HOSA) reacts with aldehydes in the presence of alcohols to produce alkyl alkanoates or benzoates. The reaction proceeds via in situ generation of nitrile and imidate intermediates. This method affords esters of aliphatic, aromatic, polycyclic, and heteroaromatic aldehydes in good to excellent yields and tolerates a variety of functional groups
{"title":"Metal‐Free Direct Esterification of Aldehydes Using Hydroxylamine‐O‐Sulfonic Acid","authors":"Ashirwad Divedi , Jawahar L. Jat","doi":"10.1002/ajoc.202500602","DOIUrl":"10.1002/ajoc.202500602","url":null,"abstract":"<div><div>Ester synthesis has traditionally depended on expensive metal catalysts and harsh reaction conditions. Despite the widespread use of these methods, challenges remain in the efficient synthesis of substituted esters. Here, we present a new metal‐free esterification method, in which hydroxylamine‐<em>O</em>‐sulfonic acid (HOSA) reacts with aldehydes in the presence of alcohols to produce alkyl alkanoates or benzoates. The reaction proceeds via in situ generation of nitrile and imidate intermediates. This method affords esters of aliphatic, aromatic, polycyclic, and heteroaromatic aldehydes in good to excellent yields and tolerates a variety of functional groups</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e00602"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The direct synthesis of propylene carbonate (PC) from propylene oxide (PO) and carbon dioxide (CO2) without the use of solvents was investigated utilizing bimetallic Fe─Cu/SBA‐15 catalysts. The Fe─Cu/SBA‐15 catalyst was prepared using the sol–gel method and was thoroughly characterized for understanding the nanostructure, morphology, and chemical composition. The catalytic performance was assessed under mild reaction conditions, specifically at atmospheric CO2 pressure, using PO as the substrate. Key reaction parameters, including temperature, catalyst dosage, and reaction time, were systematically optimized. Among the catalysts tested, 5 Fe─Cu/SBA‐15 exhibited superior activity, achieving an impressive PO conversion of 87% and PC selectivity of 95% under optimized conditions. The addition of tetrabutylammonium bromide (TBAB) as a co‐catalyst is necessary for obtaining maximum product yields. Further, the synergistic interaction between Fe and Cu was investigated, revealing that both metal species serve as active sites in catalysis. This bimetallic mesoporous material shows high recyclability for the PC synthesis, suggesting a wider scope of this work.
{"title":"Efficient Synthesis of Propylene Carbonate over Bimetallic Fe─Cu/SBA‐15 Catalyst from CO2 and Propylene Oxide","authors":"Akash Mandal , Neelanjana Ghosh , Bhabani Malakar , Dileep Kumar , Vipin Amoli , Asim Bhaumik , Biswajit Chowdhury","doi":"10.1002/ajoc.202500432","DOIUrl":"10.1002/ajoc.202500432","url":null,"abstract":"<div><div>The direct synthesis of propylene carbonate (PC) from propylene oxide (PO) and carbon dioxide (CO<sub>2</sub>) without the use of solvents was investigated utilizing bimetallic Fe─Cu/SBA‐15 catalysts. The Fe─Cu/SBA‐15 catalyst was prepared using the sol–gel method and was thoroughly characterized for understanding the nanostructure, morphology, and chemical composition. The catalytic performance was assessed under mild reaction conditions, specifically at atmospheric CO<sub>2</sub> pressure, using PO as the substrate. Key reaction parameters, including temperature, catalyst dosage, and reaction time, were systematically optimized. Among the catalysts tested, 5 Fe─Cu/SBA‐15 exhibited superior activity, achieving an impressive PO conversion of 87% and PC selectivity of 95% under optimized conditions. The addition of tetrabutylammonium bromide (TBAB) as a co‐catalyst is necessary for obtaining maximum product yields. Further, the synergistic interaction between Fe and Cu was investigated, revealing that both metal species serve as active sites in catalysis. This bimetallic mesoporous material shows high recyclability for the PC synthesis, suggesting a wider scope of this work.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e00432"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaman Lv , Wenyan Zhou , Prof. Ziyang Zhang , Dr. Lizhong Wang , Prof.Dr. Jiaming Liu , Cunde Wang
An [3 + 3] annulation of 2‐aminochromen‐4‐ones with substituted benzylidene Meldrum's acids has been developed. This reaction included a sequential intermolecular Michael addition/intramolecular nucleophilic addition/ring opening of Meldrum's acid/ removal of acetone/decarboxylation sequence, which possessed excellent step in a single operation for direct generating to substituted chromeno[2,3‐b]pyridinones from readily available substrates.
{"title":"Cs2CO3‐Mediated [3 + 3] Cyclization of 2‐Amino‐4H‐chromen‐4‐ones and Benzylidene Meldrum's Acids: Access to Chromeno[2,3‐b]pyridinones","authors":"Jiaman Lv , Wenyan Zhou , Prof. Ziyang Zhang , Dr. Lizhong Wang , Prof.Dr. Jiaming Liu , Cunde Wang","doi":"10.1002/ajoc.70205","DOIUrl":"10.1002/ajoc.70205","url":null,"abstract":"<div><div>An [3 + 3] annulation of 2‐aminochromen‐4‐ones with substituted benzylidene Meldrum's acids has been developed. This reaction included a sequential intermolecular Michael addition/intramolecular nucleophilic addition/ring opening of Meldrum's acid/ removal of acetone/decarboxylation sequence, which possessed excellent step in a single operation for direct generating to substituted chromeno[2,3‐<em>b</em>]pyridinones from readily available substrates.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e70205"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammadreza Shokouhimehr , Dokyoon Kim , M. Toufiq Reza
The demand for novel nanostructured catalysts to expedite organic transformations, including amination, Suzuki reactions, oxidation, and reduction, has been growing significantly for practical purposes in recent decades. The variability of core@shell nanostructured catalysts (CSNCs) has enabled the development of their novel implementations in sustainable and lucrative organic transformations. This perspective article delineates current advancements in the synthetic methodologies of specific CSNCs and their catalytic efficacy in selected organic reactions, such as amination, reduction, oxidation, Suzuki cross‐coupling, etc. Discussions explore the approaches and illustrations for the recyclable CSNCs, including their benefits and shortcomings, sustainability, and the effectiveness of the stated catalysts in the specified organic transformations. In addition, advancements in synergistic interactions between the cores and shells in CSNCs and sustainable systems using magnetic components for recycling techniques strove to enhance catalytic efficiency and provide cost‐effective catalysts for specific transformations.
{"title":"Core@shell Nanostructured Catalysts: Implementation in Organic Transformations","authors":"Mohammadreza Shokouhimehr , Dokyoon Kim , M. Toufiq Reza","doi":"10.1002/ajoc.202500529","DOIUrl":"10.1002/ajoc.202500529","url":null,"abstract":"<div><div>The demand for novel nanostructured catalysts to expedite organic transformations, including amination, Suzuki reactions, oxidation, and reduction, has been growing significantly for practical purposes in recent decades. The variability of core@shell nanostructured catalysts (CSNCs) has enabled the development of their novel implementations in sustainable and lucrative organic transformations. This perspective article delineates current advancements in the synthetic methodologies of specific CSNCs and their catalytic efficacy in selected organic reactions, such as amination, reduction, oxidation, Suzuki cross‐coupling, etc. Discussions explore the approaches and illustrations for the recyclable CSNCs, including their benefits and shortcomings, sustainability, and the effectiveness of the stated catalysts in the specified organic transformations. In addition, advancements in synergistic interactions between the cores and shells in CSNCs and sustainable systems using magnetic components for recycling techniques strove to enhance catalytic efficiency and provide cost‐effective catalysts for specific transformations.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 11","pages":"Article e00529"},"PeriodicalIF":2.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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