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MicroRNA-181b-5p/HEY2 axis is involved in the progress of deep venous thrombosis via mediating vascular endothelial injury. MicroRNA-181b-5p/HEY2轴通过介导血管内皮损伤参与深静脉血栓形成的进展。
IF 2 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1080/16078454.2024.2423438
Dawei Zhang, Cheng Cheng, Meiying Yang, Xiuyin Zhang, Xinming Yu, Min Wang

Objectives: Deep-venous thrombosis (DVT) refers to abnormal blood clotting in the deep vein cavity, and post-thrombotic syndrome (PTS) is the most frequent complication. The study explored the impact of microRNA 181b-5p on DVT progression based on human umbilical vein endothelial cells (HUVECs).

Methods: Levels of miR-181b-5p were examined in 150 cases with acute lower extremity DVT. ROC curve and K-M plot were drawn for clinical value assessment. The role of miR-181b-5p in HUVECs viability, migration, apoptosis, inflammatory response and adhesion factors' release was investigated. Target gene of miR-181b-5p was predicted, and its role in cell function was explored.

Results: Low-expressed miR-181b-5p showed favorable diagnostic performance in differentiating DVT with the AUC of 0.948. Patients with low miR-181b-5p had a high incidence of PTS. miR-181b-5p overexpression promoted HUVECs' viability and migration, while inhibiting cell apoptosis and release of inflammatory and adhesion cytokines. As the target gene of miR-181b-5p, HEY2 overexpression reversed the role of miR-181b-5p in HUVECs.

Conclusion: MiR-181b-5p serves as a potential biomarker for DVT diagnosis and PTS development. Overexpression of this miRNA targeted HEY2 to alleviate endothelial cell damage.

目的:深静脉血栓(DVT)是指深静脉腔内异常凝血,血栓后综合征(PTS)是最常见的并发症。本研究以人脐静脉内皮细胞(HUVECs)为研究对象,探讨了microRNA 181b-5p对DVT进展的影响:方法:研究了150例急性下肢深静脉血栓患者的miR-181b-5p水平。绘制 ROC 曲线和 K-M 图以评估临床价值。研究了 miR-181b-5p 在 HUVECs 存活、迁移、凋亡、炎症反应和粘附因子释放中的作用。预测了 miR-181b-5p 的靶基因,并探讨了其在细胞功能中的作用:结果:低表达 miR-181b-5p 在鉴别深静脉血栓的诊断中表现良好,AUC 为 0.948。miR-181b-5p过表达可促进HUVECs的活力和迁移,同时抑制细胞凋亡和炎症及粘附细胞因子的释放。作为 miR-181b-5p 的靶基因,HEY2 的过表达逆转了 miR-181b-5p 在 HUVECs 中的作用:结论:miR-181b-5p 是深静脉血栓诊断和创伤后应激反应发展的潜在生物标志物。结论:MiR-181b-5p 是诊断深静脉血栓和 PTS 发展的潜在生物标志物,过表达该 miRNA 可靶向 HEY2 减轻内皮细胞损伤。
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引用次数: 0
Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells. 活化的Tim-3/Galectin-9通过负向调节CD4 T细胞参与了多发性骨髓瘤的发展。
IF 1.9 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2023-12-18 DOI: 10.1080/16078454.2023.2288481
Rui Zhang, Shuang Chen, Tingting Luo, Sha Guo, Jianhua Qu

The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, the regulation of Tim-3/Galectin-9 on CD4 T cell subsets in multiple myeloma (MM) remains unclear. The aim of this study was to investigate the relationship between the regulation of CD4 T cell subsets by the Tim-3/Galectin-9 pathway and clinical prognostic indicators in MM. Tim-3/Galectin-9 were detected by flow cytometry, PCR and ELISA in 60 MM patients and 40 healthy controls, and its correlation with clinical prognostic parameters was analyzed. The expressions of Tim-3 on CD4 T cells, Galectin-9 mRNA in PBMC and level of Galectin-9 protein in serum were significantly elevated in MM patients, especially those with poor prognostic indicators. In MM patients, Tim-3 was highly expressed on the surfaces of Th1, Th2, and Th17 cells, but lowly expressed on Treg. Moreover, level of cytokine IFN-γ in serum was negatively correlated with Tim-3+Th1 cell and Galectin-9mRNA, Galectin-9 protein level. In addition, cell culture experiments showed that the anti-tumor effect and the ability to secrete IFN-γ were restored by blocking the Tim-3/Galectin-9 pathway. In MM patients, Tim-3/Galectin-9 is elevated and associated with disease progression, by inhibiting the cytotoxic function of Th1, and also promoting Th2 and Th17 to be involved in immune escape of MM. Therefore, Tim-3/Galectin-9 may serve as a new immunotherapeutic target for MM patients.

T细胞上的Tim-3与其配体Galectin-9之间的相互作用对细胞免疫反应起着负向调节作用。然而,Tim-3/Galectin-9对多发性骨髓瘤(MM)CD4 T细胞亚群的调控作用仍不清楚。本研究旨在探讨Tim-3/Galectin-9通路对CD4 T细胞亚群的调控与多发性骨髓瘤临床预后指标之间的关系。通过流式细胞术、PCR和ELISA检测了60名MM患者和40名健康对照者的Tim-3/Galectin-9,并分析了其与临床预后指标的相关性。在 MM 患者中,尤其是预后指标较差的患者,CD4 T 细胞中 Tim-3 的表达、PBMC 中 Galectin-9 mRNA 的表达以及血清中 Galectin-9 蛋白的水平均显著升高。在 MM 患者中,Th1、Th2 和 Th17 细胞表面高表达 Tim-3,而 Treg 细胞表面低表达 Tim-3。此外,血清中细胞因子IFN-γ的水平与Tim-3+Th1细胞和Galectin-9mRNA、Galectin-9蛋白水平呈负相关。此外,细胞培养实验表明,阻断Tim-3/Galectin-9通路可恢复抗肿瘤作用和分泌IFN-γ的能力。在 MM 患者中,Tim-3/Galectin-9 通过抑制 Th1 的细胞毒性功能,促进 Th2 和 Th17 参与 MM 的免疫逃逸,从而升高并与疾病进展相关。因此,Tim-3/Galectin-9 可作为 MM 患者新的免疫治疗靶点。
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引用次数: 0
Effective treatment with Gilteritinib-based regimens for FLT3-mutant extramedullary relapse in acute promyelocytic leukemia. 以吉替替尼为基础的方案有效治疗急性早幼粒细胞白血病的FLT3突变髓外复发。
IF 1.9 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2023-12-14 DOI: 10.1080/16078454.2023.2293496
Chun-Xiao Hou, Yu Chen, Shan-Hao Liu, Yi-Zhi Jiang, Dong-Ping Huang, Su-Ning Chen

Objective: Extramedullary relapse (EMR) is rare in acute promyelocytic leukemia (APL) and, there is a lack of information on its management. Current practices for EMR in APL are always to adopt strategies from other subtypes of Acute lymphoblastic leukemia (ALL) and Acute myeloid leukemia (AML). Gilteritinib, a highly selective FLT3 inhibitor, has demonstrated a remarkable effect on EMR in FLT3-mutant AML. Therefore, it is worthwhile exploring if FLT3 mutation can be a therapeutic target and assessing the efficacy of Gilteritinib on FLT3-mutant EMR in APL.

Methods: We described three cases of FLT3-mutant EMR in APL, comprising two isolated EMR cases and one systemic relapse. The patients underwent treatment with Gilteritinib-based regimens based on FLT3 mutation.

Results: All three patients achieved complete regression of EMR, and no signs of tumor lysis syndrome during Gilteritinib-based therapy, only patient 1 showed mild granulocytopenia. They all maintained molecular complete remission (mCR) during the follow-up period.

Conclusions: The Gilteritinib-based regimen shows a high and sustained therapeutic effect with minimal adverse effects, and provides a valuable experience for further evaluation in EMR APL patients.

目的:髓外复发(EMR)在急性早幼粒细胞白血病(APL)中非常罕见,目前缺乏有关其治疗的信息。目前治疗急性早幼粒细胞白血病髓外复发的方法总是采用急性淋巴细胞白血病(ALL)和急性髓细胞白血病(AML)其他亚型的策略。Gilteritinib 是一种高选择性 FLT3 抑制剂,对 FLT3 突变 AML 的 EMR 有显著效果。因此,值得探讨FLT3突变是否可以作为治疗靶点,并评估吉尔替尼对APL中FLT3突变EMR的疗效:我们描述了三例APL中的FLT3突变EMR,包括两例孤立EMR和一例全身复发。这些患者接受了基于FLT3突变的吉特替尼治疗方案:结果:三例患者均实现了EMR的完全缓解,且在吉特替尼治疗期间未出现肿瘤溶解综合征,只有患者1出现了轻度粒细胞减少。他们在随访期间均保持了分子完全缓解(mCR):基于吉尔替尼的方案显示出较高的持续治疗效果,且不良反应极少,为进一步评估EMR APL患者提供了宝贵的经验。
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引用次数: 0
Prevalence of hemoglobinopathies among Malayali tribes of Jawadhu hills, Tiruvannamalai district, Tamil Nadu, India: a community-based cross-sectional study. 印度泰米尔纳德邦 Tiruvannamalai 区 Jawadhu 山马拉雅族部落中血红蛋白病的患病率:一项基于社区的横断面研究。
IF 1.9 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-05-14 DOI: 10.1080/16078454.2024.2350320
Balasubramanian Ganesh, Thangarasu Rajakumar, Subhendu Kumar Acharya, Shanmugasundaram Devika, Venkatachalam Ramachandran, Jayaram Yuvaraj, Anita Nadkarni, Shanmugam Rajasubramaniam, Harpreet Kaur

Background: Hemoglobin (Hb), a red pigment of red blood cells (RBCs), carries oxygen from the lungs to different organs of the body and transports carbon dioxide back to the lungs. Any fault present in the Hb structure leads to undesirable functional effects of the RBCs, such as sickle cell anemia (SCA), thalassemia, etc. Hemoglobinopathies affect around 7% of people in both developed and developing countries globally. The aim of the present study was to determine the prevalence and carrier frequencies of hemoglobinopathies including SCA, thalassemia, and other abnormal Hb variants among Malayali tribes in the Jawadhu hills of Tiruvannamalai district, Tamil Nadu, India.

Methods: A community-based cross-sectional study was carried out among 443 Malayali tribes inhabiting the Jawadhu hills of Tiruvannamalai district from July 2022 to September 2022. The RBC indices were analyzed using an automated 5-part hematology analyzer (Mindray, BC-5150) and hemoglobin fractions were done using the HPLC system (Bio-Rad, D-10) following standard protocols.

Findings: A total of 443 participants were screened, out of whom 14.67% had an abnormal Hb fraction, 83.30% were identified as normal, and 2.03% were borderline. Notably, the study revealed a prevalence of 0.68% for the α-thalassemia trait and 13.99% for the β-thalassemia trait.

Interpretation: Haemoglobinopathies, specifically the β-thalassemia trait, were most prevalent among the Malayali tribal population of Tamil Nadu residing in the Jawadhu hills of Tiruvannamalai district. Hence, we need special attention for creating awareness, increasing hemoglobinopathies screening programs, and improving the importance of tribal health conditions by the government and non-governmental organizations (NGOs) for the betterment of the ethnic tribes.

背景:血红蛋白(Hb)是红细胞(RBC)中的一种红色色素,可将氧气从肺部运送到身体的不同器官,并将二氧化碳运送回肺部。血红蛋白结构中的任何缺陷都会导致红细胞产生不良的功能影响,如镰状细胞性贫血(SCA)、地中海贫血症等。在全球发达国家和发展中国家,约有 7% 的人患有血红蛋白病。本研究旨在确定血红蛋白病(包括镰状细胞性贫血、地中海贫血和其他异常 Hb 变异)在印度泰米尔纳德邦蒂鲁凡纳马莱地区 Jawadhu 山的马拉雅部落中的流行率和携带者频率:从 2022 年 7 月到 2022 年 9 月,对居住在蒂鲁凡纳马莱地区 Jawadhu 山的 443 个马拉雅族部落进行了社区横断面研究。根据标准方案,使用全自动 5 部分血液分析仪(Mindray, BC-5150)分析红细胞指数,并使用高效液相色谱系统(Bio-Rad, D-10)进行血红蛋白分馏:共筛查了 443 名参与者,其中 14.67% 的人血红蛋白分数异常,83.30% 的人血红蛋白分数正常,2.03% 的人血红蛋白分数处于边缘状态。值得注意的是,研究显示α地中海贫血特质的发病率为 0.68%,β地中海贫血特质的发病率为 13.99%:血红蛋白病,尤其是β-地中海贫血症,在居住在提鲁凡纳马莱地区贾瓦杜山的泰米尔纳德邦马拉雅部落人口中最为普遍。因此,我们需要政府和非政府组织(NGOs)特别关注提高认识,增加血红蛋白病筛查项目,提高对部落健康状况的重视程度,以改善少数民族部落的状况。
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引用次数: 0
Attitude towards blood donation and its associated factors, types of blood donation, willingness, and feeling towards blood donation among potential blood donors in Ethiopia: systematic review and meta-analysis, observational study. 埃塞俄比亚潜在献血者的献血态度及其相关因素、献血类型、献血意愿和献血感受:系统回顾和荟萃分析观察研究。
IF 1.9 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-05-17 DOI: 10.1080/16078454.2024.2355600
Addisu Getie, Adam Wondmieneh, Melaku Bimerew

Introduction: Blood donation is crucial for certain populations, such as pregnant mothers, anemic patients, traumatized patients, and individuals undergoing surgery. The imbalance between the number of blood donors and the demand for blood in Ethiopia is a serious public health concern. Having a favorable attitude towards blood donation could aid in correcting this imbalance. Therefore, this study aimed to assess the proportion of favorable attitudes, types of blood donation, willingness, and feelings towards blood donation in Ethiopia.

Methods: Several databases were searched to retrieve the available articles. Heterogeneity and publication bias were assessed using the Galbraith plot with Cochrane I2 statistics and funnel plot with Egger's test, respectively. Subgroup analysis was done to identify the cause of the substantial heterogeneity.

Result: The pooled prevalence of favorable attitudes about blood donation was 65.28% (60.10-70.47). A higher prevalence was reported among studies conducted after 2020, in Northern Ethiopia and among health care professionals: 72.66%, 68.45%, and 69.41%, respectively. The percentages of people who had good feelings, willing to donate, and encouraged others to donate are 83.99%, 74.23%, and 77.96%, respectively. Conversely, 42.84% of participants believe that risk will happen following donation. There was an association between knowledge and attitude towards blood donation (AOR = 1.76; 95% CI: 1.48-2.99).

Conclusion: The findings of this study may imply the preparation of a blood donation campaign that helps the community. Concerned bodies from governmental and non-governmental organizations may arrange and design community education, which may increase the number of voluntary donors.

导言:献血对某些人群至关重要,如孕妇、贫血患者、创伤患者和手术患者。在埃塞俄比亚,献血者人数与血液需求之间的不平衡是一个严重的公共卫生问题。对献血持积极态度有助于纠正这种失衡。因此,本研究旨在评估埃塞俄比亚人对献血的良好态度比例、献血类型、献血意愿和献血感受:搜索了多个数据库以检索可用文章。分别使用 Galbraith 图与 Cochrane I2 统计量和漏斗图与 Egger 检验来评估异质性和发表偏倚。还进行了分组分析,以确定造成大量异质性的原因:结果:对献血持赞成态度的总体流行率为 65.28%(60.10-70.47)。在 2020 年之后进行的研究中,埃塞俄比亚北部和医疗保健专业人员中的流行率较高:分别为 72.66%、68.45% 和 69.41%。有好感、愿意捐赠和鼓励他人捐赠的比例分别为 83.99%、74.23% 和 77.96%。相反,42.84% 的参与者认为捐赠后会有风险。献血知识与献血态度之间存在关联(AOR = 1.76;95% CI:1.48-2.99):本研究的结果可能意味着需要准备一场有助于社区的献血活动。政府和非政府组织的相关机构可安排和设计社区教育,从而增加自愿献血者的人数。
{"title":"Attitude towards blood donation and its associated factors, types of blood donation, willingness, and feeling towards blood donation among potential blood donors in Ethiopia: systematic review and meta-analysis, observational study.","authors":"Addisu Getie, Adam Wondmieneh, Melaku Bimerew","doi":"10.1080/16078454.2024.2355600","DOIUrl":"https://doi.org/10.1080/16078454.2024.2355600","url":null,"abstract":"<p><strong>Introduction: </strong>Blood donation is crucial for certain populations, such as pregnant mothers, anemic patients, traumatized patients, and individuals undergoing surgery. The imbalance between the number of blood donors and the demand for blood in Ethiopia is a serious public health concern. Having a favorable attitude towards blood donation could aid in correcting this imbalance. Therefore, this study aimed to assess the proportion of favorable attitudes, types of blood donation, willingness, and feelings towards blood donation in Ethiopia.</p><p><strong>Methods: </strong>Several databases were searched to retrieve the available articles. Heterogeneity and publication bias were assessed using the Galbraith plot with Cochrane I<sup>2</sup> statistics and funnel plot with Egger's test, respectively. Subgroup analysis was done to identify the cause of the substantial heterogeneity.</p><p><strong>Result: </strong>The pooled prevalence of favorable attitudes about blood donation was 65.28% (60.10-70.47). A higher prevalence was reported among studies conducted after 2020, in Northern Ethiopia and among health care professionals: 72.66%, 68.45%, and 69.41%, respectively. The percentages of people who had good feelings, willing to donate, and encouraged others to donate are 83.99%, 74.23%, and 77.96%, respectively. Conversely, 42.84% of participants believe that risk will happen following donation. There was an association between knowledge and attitude towards blood donation (AOR = 1.76; 95% CI: 1.48-2.99).</p><p><strong>Conclusion: </strong>The findings of this study may imply the preparation of a blood donation campaign that helps the community. Concerned bodies from governmental and non-governmental organizations may arrange and design community education, which may increase the number of voluntary donors.</p>","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"29 1","pages":"2355600"},"PeriodicalIF":1.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of BACH1 in multiple myeloma. BACH1 在多发性骨髓瘤中的作用
IF 2 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-05-20 DOI: 10.1080/16078454.2024.2352687
Yan Chen, Zhiyong Zeng, Junmin Chen

Objective: Examine Bach1 protein expression in bone marrow biopsy specimens obtained from newly diagnosed multiple myeloma (NDMM) and iron deficiency anemia (IDA) patients. Conduct a thorough analysis to explore the potential connection between Bach1 and the onset as well as treatment response of NDMM.

Methods: This study investigated Bach1 expression in bone marrow biopsy tissues from NDMM and IDA patients. Immunohistochemical staining and Image-pro Plus software were utilized for quantitatively obtaining the expression level of Bach1 protein. Arrange Bach1 expression levels from high to low, and use its median expression level as the threshold. Samples with Bach1 expression level above the median are categorized as the high-expression group, while those below the median are categorized as the low-expression group. Under this grouping, a detailed discussion was conducted to explore relationship of the Bach1 expression level with the patients' gender, ISS stage, and survival rate based on the Bortezomib (Btz) therapy.

Results: Our experiment indicates that the expression level of Bach1 in NDMM patients is significantly higher than in IDA patients. Furthermore, we discovered that patients in the high-expression group exhibit better prognosis compared to those in the low-expression group after Btz-treatment. Bioinformatics analysis further confirms this conclusion.

Conclusion: By categorizing Bach1 expression level as high and low, our study offers a unique perspective on understanding the relationship between Bach1 and NDMM.

目的研究新诊断的多发性骨髓瘤(NDMM)和缺铁性贫血(IDA)患者骨髓活检标本中Bach1蛋白的表达。进行全面分析,探讨 Bach1 与 NDMM 发病及治疗反应之间的潜在联系:本研究调查了 Bach1 在 NDMM 和 IDA 患者骨髓活检组织中的表达情况。采用免疫组化染色和Image-pro Plus软件定量检测Bach1蛋白的表达水平。将 Bach1 的表达水平从高到低排列,并以其表达水平的中位数作为阈值。将 Bach1 表达水平高于中位数的样本归为高表达组,低于中位数的样本归为低表达组。在此分组基础上,详细讨论了 Bach1 表达水平与患者性别、ISS 分期和硼替佐米(Btz)疗法存活率的关系:实验结果表明,Bach1在NDMM患者中的表达水平明显高于IDA患者。此外,我们还发现,在接受硼替佐米(Btz)治疗后,高表达组患者的预后优于低表达组患者。生物信息学分析进一步证实了这一结论:通过将 Bach1 的表达水平分为高表达和低表达,我们的研究为理解 Bach1 与 NDMM 之间的关系提供了一个独特的视角。
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引用次数: 0
Metabolomics-based study on the significance of differential metabolite binding IgG isoforms in Hemolytic disease of newborn. 基于代谢组学的新生儿溶血病中不同代谢物结合IgG同工酶的意义研究
IF 1.9 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-06-03 DOI: 10.1080/16078454.2024.2360339
Shipeng Zhang, Sijin Li, Xuan Meng, Jia Chen, Yan Tang, Xiaobin Li

Background: Hemolytic disease of the newborn (HDN) is a common condition that can have a severe impact on the health of newborns due to the hemolytic reactions it triggers. Although numerous studies have focused on understanding the pathogenesis of HDN, there are still many unanswered questions.

Methods: In this retrospective study, serum samples were collected from 15 healthy newborns and 8 infants diagnosed with hemolytic disease. The relationship between different metabolites and various IgG subtypes in Healthy, HDN and BLI groups was studied by biochemical technique and enzyme-linked immunosorbent assay (ELISA). Metabolomics analysis was conducted to identify the differential metabolites associated with HDN. Subsequently, Pearson's correlation analysis was used to determine the relation of these differential metabolites with IgG isoforms. The relationship between the metabolites and IgG subtypes was observed after treatment.

Results: The study results revealed that infants with hemolytic disease exhibited abnormal elevations in TBA, IgG1, IgG2a, IgG2b, IgG3, and IgG4 levels when compared to healthy newborns. Additionally, differences in metabolite contents were also observed. N, N-DIMETHYLARGININE showed negative correlations with TBA, IgG1, IgG2a, IgG2b, IgG3, and IgG4, while 2-HYDROXYBUTYRATE, AMINOISOBUTANOATE, Inosine, and ALLYL ISOTHIOCYANATE exhibited positive correlations with TBA, IgG1, IgG2a, IgG2b, IgG3, and IgG4. Through metabolomics-based research, we have discovered associations between differential metabolites and different IgG isoforms during the onset of HDN.

Conclusion: These findings suggest that changes in metabolite and IgG isoform levels are linked to HDN. Understanding the involvement of IgG isoforms and metabolites can provide valuable guidance for the diagnosis and treatment of HDN.

背景:新生儿溶血病(HDN新生儿溶血病(HDN)是一种常见疾病,由于其引发的溶血反应会严重影响新生儿的健康。尽管许多研究都致力于了解 HDN 的发病机理,但仍有许多问题尚待解答:在这项回顾性研究中,采集了 15 名健康新生儿和 8 名确诊为溶血性疾病的婴儿的血清样本。通过生化技术和酶联免疫吸附试验(ELISA)研究了健康组、HDN 组和 BLI 组不同代谢物与各种 IgG 亚型之间的关系。代谢组学分析旨在确定与 HDN 相关的不同代谢物。随后,利用皮尔逊相关分析确定了这些差异代谢物与 IgG 同工酶的关系。治疗后观察代谢物与 IgG 亚型之间的关系:研究结果表明,与健康新生儿相比,溶血病婴儿的 TBA、IgG1、IgG2a、IgG2b、IgG3 和 IgG4 水平异常升高。此外,还观察到代谢物含量的差异。N,N-二甲基乙炔与 TBA、IgG1、IgG2a、IgG2b、IgG3 和 IgG4 呈负相关,而 2-羟基丁酸、氨异丁酸、肌苷和 ALLYL 异硫氰酸与 TBA、IgG1、IgG2a、IgG2b、IgG3 和 IgG4 呈正相关。通过基于代谢组学的研究,我们发现了在 HDN 发病期间不同代谢物与不同 IgG 同工酶之间的关联:这些发现表明,代谢物和 IgG 同工酶水平的变化与 HDN 有关。了解 IgG 同工酶和代谢物的参与可为 HDN 的诊断和治疗提供有价值的指导。
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引用次数: 0
Non-invasive hemoglobin screening device: a promising digital method for reducing anemia prevalence through routine screening and timely intervention. 无创血红蛋白筛查设备:通过常规筛查和及时干预降低贫血患病率的前景看好的数字方法。
IF 1.9 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-06-12 DOI: 10.1080/16078454.2024.2365078
Partha Pratim Das Mahapatra, Chaitali Roy, Komal Agarwal, Sonal Deep Sharma, Sudip Roy Chowdhury, Sandeep Sharma, Harshavardhan Rajagopal, Dayanidhi Meher

Background: Several non-invasive technologies are nowadays available in the market which claim to determine the hemoglobin levels instantly without the requirement of the blood sample. But no study has shown the significance of such non-invasive devices on a routine basis for determining their impact on anemia reduction programs. This study is conducted to determine the impact of regular hemoglobin screening on the women population to determine its potential in reducing anemia, using a digitalized non-invasive device.

Method: A cross-sectional study was conducted on 203 women of reproductive age group, residing in the Moradabad district. Repetitive readings were taken after a time interval of a minimum of 1 month for determining the impact of regular screening. The entire data collection process was carried out using the EzeCheck mobile app.

Results: It was observed that the prevalence of anemia was reduced upon the second time screening and was accepted by the women population. Repetitive testing has a significant impact on reducing anemia prevalence. Also, the simplified non-invasive technology for estimating the hemoglobin values, makes the user more comfortable to take the test.

Conclusion: Non-invasive devices should be used regularly to keep track of hemoglobin levels which will help in the effective treatment of anemia. The mobile app-based testing could help to easily evaluate the reports of the patients from any remote location with instant result interpretation and health assistance.

背景:如今,市场上出现了几种无创技术,它们声称无需血液样本即可即时测定血红蛋白水平。但是,还没有研究表明这种非侵入性设备在常规基础上对确定其对减少贫血计划的影响有多大意义。本研究旨在确定定期血红蛋白筛查对妇女人群的影响,以确定其使用数字化无创设备减少贫血的潜力:方法:对居住在莫拉达巴德地区的 203 名育龄妇女进行了横断面研究。为确定定期筛查的影响,至少间隔一个月后重复读数。整个数据收集过程使用 EzeCheck 移动应用程序进行:结果:据观察,第二次筛查后贫血患病率有所下降,并得到了妇女群体的认可。重复检测对降低贫血患病率有显著影响。此外,估算血红蛋白值的简化无创技术也让用户更愿意接受测试:结论:应定期使用无创设备来跟踪血红蛋白水平,这将有助于有效治疗贫血。基于移动应用程序的测试有助于从任何远程地点轻松评估患者的报告,并提供即时结果解释和健康援助。
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引用次数: 0
Patient-centric care in primary immune thrombocytopenia (ITP): shared decision-making and assessment of health-related quality of life. 以患者为中心的原发性免疫性血小板减少症(ITP)护理:共同决策和健康相关生活质量评估。
IF 2 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-07-08 DOI: 10.1080/16078454.2024.2375177
Hillary Maitland, Catherine Lambert, Waleed Ghanima

ABSTRACTImmune thrombocytopenia (ITP), an autoimmune disease characterized by low platelet counts and increased bleeding risk, can impair health-related quality of life (HRQoL), impacting patients' daily lives and mental health. A number of patient-reported outcome (PRO) measures (both generic and specific to ITP) can be used to understand the impact of ITP on HRQoL and generate evidence to guide disease management. As well-developed PRO tools could help in HRQoL assessment, their optimization could help to solidify a patient-centric approach to ITP management. Shared decision-making is a collaborative process between a patient and their healthcare professional in making decisions about care. Treatment decisions based on this shared process between physician and patient are recommended by clinical guidelines. The goal of this narrative review is to discuss treatment decisions with regards to patient-centric ITP management, with a focus on the impact of PRO measures and the process of shared decision-making in practice.

摘要免疫性血小板减少症(ITP)是一种以血小板计数低和出血风险增加为特征的自身免疫性疾病,会损害与健康相关的生活质量(HRQoL),影响患者的日常生活和心理健康。一些患者报告的结果(PRO)测量方法(包括通用的和针对 ITP 的)可用于了解 ITP 对 HRQoL 的影响,并为指导疾病管理提供证据。由于完善的PRO工具有助于进行HRQoL评估,因此对其进行优化有助于巩固以患者为中心的ITP管理方法。共同决策是患者与医护人员在做出治疗决定时的一个合作过程。临床指南推荐在医患双方共同决策的基础上做出治疗决定。本综述旨在讨论以患者为中心的 ITP 管理方面的治疗决策,重点关注 PRO 测量和共同决策过程在实践中的影响。
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引用次数: 0
Role of metabolites in mediating the effect of triacylglycerol on aplastic anemia. 代谢物在调节三酰甘油对再生障碍性贫血的影响中的作用
IF 2 4区 医学 Q3 HEMATOLOGY Pub Date : 2024-12-01 Epub Date: 2024-07-17 DOI: 10.1080/16078454.2024.2379178
Jingkui Zhu, Wen Li

Background: Observational studies have found a link between lipid metabolism disorders and aplastic anemia (AA). However, due to confounding variables and reverse causation, it is difficult to conclude such a causal link. The precise mechanism and potential implications of lipid metabolism disorder in AA remain unclear, necessitating further studies in this area.

Method: This study aimed to examine the causal relationship between 38 different subtypes of triacylglycerols and AA using two-sample Mendelian randomization (MR). Additionally, two-step MR analyses were conducted to investigate the mediating effects of vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio.

Results: MR analysis showed that triacylglycerol (53:3) levels were positively associated with the risk of AA [inverse variance weighting (IVW): odds ratio (OR) = 1.131,95% confidence interval (CI):1.029-1.243, P = 0.011; Bayesian weighted MR (BWMR): OR = 1.137,95% CI:1.031-1.254, P = 0.010]. Triacylglycerol (53:3) level showed no inverse causality with AA (IVW:P = 0.834; BWMR:P = 0.349). Mediation analyses showed that increasing the vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio can decrease the risk of AA.

Conclusion: This study revealed the association between vitamin A to oleoyl-linoleoyl-glycerol (18:1-18:2) ratio, triacylglycerol (53:3) levels and AA, and indicated that lowering triacylglycerol (53:3) levels can reduce the risk of AA.

背景:观察性研究发现,脂质代谢紊乱与再生障碍性贫血(AA)之间存在联系。然而,由于混杂变量和反向因果关系,很难得出这种因果关系的结论。脂质代谢紊乱在再生障碍性贫血中的确切机制和潜在影响仍不清楚,因此有必要在这一领域开展进一步研究:本研究旨在使用双样本孟德尔随机法(MR)研究 38 种不同亚型的三酰甘油与 AA 之间的因果关系。此外,还进行了两步 MR 分析,以研究维生素 A 与油酰基-亚油酰基甘油(18:1-18:2)比率的中介效应:或 = 1.137,95% 置信区间:1.031-1.254,P = 0.010]。三酰甘油(53:3)水平与 AA 没有反向因果关系(IVW:P = 0.834;BWMR:P = 0.349)。中介分析表明,提高维生素 A 与油酰基-亚油酰基甘油(18:1-18:2)的比率可降低 AA 风险:本研究揭示了维生素 A 与油酰基-亚油酰基-甘油(18:1-18:2)比率、三酰甘油(53:3)水平与 AA 之间的关系,并指出降低三酰甘油(53:3)水平可降低 AA 风险。
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Hematology
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