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Identification of the novel HLA-A*02:01:189 allele 新型 HLA-A*02:01:189 等位基因的鉴定。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-27 DOI: 10.1111/tan.15651
Maria Troiano, Antonio Giuseppe Bianculli, Andrea Di Luzio, Rita Maria Pinto, Marco Andreani

HLA-A*02:01:189 differs from HLA-A*02:01:01:01 by one nucleotide substitution in Exon 3, codon 101 TGC > TGT.

HLA-A*02:01:189与HLA-A*02:01:01:01的区别在于外显子3中一个核苷酸的替换，密码子101 TGC > TGT。
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引用次数: 0
Characterisation of the novel HLA-DQB1*06:02:62 allele using short- and long-read sequencing technologies 利用短线程和长线程测序技术确定新型 HLA-DQB1*06:02:62 等位基因的特征。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-27 DOI: 10.1111/tan.15663
Victoria Oliveira, Jonathan Pinto, Romulo Vianna, Luís Cristóvão Porto, Danielle Secco

The novel HLA-DQB1*06:02:62 allele, first described in an individual from Brazil.

新型 HLA-DQB1*06:02:62 等位基因，首次出现在巴西的一个人身上。
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引用次数: 0
Identification of the novel HLA-B*51:360 allele in a Chinese individual 在一名中国人身上发现新型 HLA-B*51:360 等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-27 DOI: 10.1111/tan.15660
Lina Dong, Qi Li, Fang Wang, Wei Zhang, Faming Zhu

HLA-B*51:360 differs from HLA-B*51:01:01:01 by a single nucleotide substitution at position 955 G > A in exon 5.

HLA-B*51:360与HLA-B*51:01:01:01的区别在于外显子5的955位G > A的单核苷酸替换。
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引用次数: 0
The novel HLA-A*24:618 allele identified in Ecuadorian individual from New York City 在纽约市的厄瓜多尔人中发现新型 HLA-A*24:618 等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-27 DOI: 10.1111/tan.15662
Claire Zheng, Vasudha Eravelli, Malgorzata Kosierb, Jasmine Ge, S. Yoon Choo
{"title":"The novel HLA-A*24:618 allele identified in Ecuadorian individual from New York City","authors":"Claire Zheng,&nbsp;Vasudha Eravelli,&nbsp;Malgorzata Kosierb,&nbsp;Jasmine Ge,&nbsp;S. Yoon Choo","doi":"10.1111/tan.15662","DOIUrl":"10.1111/tan.15662","url":null,"abstract":"","PeriodicalId":13172,"journal":{"name":"HLA","volume":null,"pages":null},"PeriodicalIF":5.9,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The novel non-classical HLA-G*01:55 identified in a Chinese individual 在一名中国人身上发现的新型非典型 HLA-G*01:55。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-22 DOI: 10.1111/tan.15657
Zhan-Rou Quan, Jie Liu, Bing-Na Yang, Jia-Min Song, Hong-Yan Zou

The non-classical HLA-G*01:55 allele differs from G*01:01:12 at one position in exon 4.

非典型 HLA-G*01:55 等位基因在外显子 4 的一个位置上与 G*01:01:12 不同。
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引用次数: 0
Introduction of the donor centre virtual crossmatch in Eurotransplant 在欧洲移植中引入供体中心虚拟交叉配型。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-22 DOI: 10.1111/tan.15653
Sebastiaan Heidt, Cynthia S. M. Kramer, Geert W. Haasnoot, Alexander H. Schmidt, Yvonne M. Zoet, Frans H. J. Claas, Serge Vogelaar

On 24 January 2023, Eurotransplant has introduced the virtual crossmatch for kidney and pancreas allocation as a better alternative for the physical Complement Dependent Cytotoxicity (CDC) crossmatches at the donor centre, which were associated with a longer cold ischaemia time and false positive reactions. For the time being, the physical CDC crossmatch at the recipient centre will remain in place as the final histocompatibility check. While Eurotransplant is certainly not the first organ allocation organisation to introduce virtual crossmatching, several novel aspects have been introduced, such as calculation of the virtual panel reactive antibody (vPRA) on 11 loci at the second-field level in addition to the serological broad and split level, electronic HLA typing data transmission using Histoimmunogenetics Markup Language (HML) file format, and the actual virtual crossmatch based on ambiguous, second-field HLA typing of the donor on all 11 loci. This short communication will focus on these novel aspects of the virtual crossmatch in Eurotransplant.

2023 年 1 月 24 日，欧洲移植中心在肾脏和胰腺分配中引入了虚拟交叉配型，以更好地替代在供体中心进行的补体依赖性细胞毒性（CDC）交叉配型，后者与较长的冷缺血时间和假阳性反应有关。目前，受体中心的物理 CDC 交叉配型仍将作为最后的组织相容性检查。虽然欧洲器官移植中心肯定不是第一个引入虚拟交叉配型的器官分配机构，但它已经引入了几个新的方面，例如，除了血清学广域和分割水平外，还在第二领域水平上计算 11 个位点的虚拟面板反应抗体 (vPRA)，使用组织免疫遗传学标记语言 (HML) 文件格式进行电子 HLA 分型数据传输，以及根据供体在所有 11 个位点上的模棱两可的第二领域 HLA 分型进行实际虚拟交叉配型。这篇短文将重点介绍欧洲移植中虚拟交叉配型的这些新颖之处。
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引用次数: 0
The novel HLA-DPB1*04:02:01:44 allele identified in a volunteer bone marrow donor 在一名志愿骨髓捐献者身上发现的新型 HLA-DPB1*04:02:01:44 等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-22 DOI: 10.1111/tan.15659
Ekaterina Khamaganova, Evgeny Leonov, Irina Pavlova, Albert J. E. French, Sebastian J. F. Hopper

Nucleotide substitution in the intron 2 of HLA-DPB1*04:02:01:01 results in a novel allele, HLA-DPB1*04:02:01:44.

HLA-DPB1*04:02:01:01内含子2中的核苷酸替换产生了一个新的等位基因--HLA-DPB1*04:02:01:44。
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引用次数: 0
Identification of four novel KIR alleles in haematopoietic stem cell donors of Indian origin 在印度裔造血干细胞捐献者中鉴定出四种新型 KIR 等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-20 DOI: 10.1111/tan.15648
Disha Agarwal, Gaurav Sharma, Alka Khadwal, Pankaj Malhotra

Four novel KIR alleles KIR3DL1*0010120, KIR3DS1*01315, KIR3DL3*0020703 and KIR2DL4*0010310 identified using next-generation sequencing.

利用新一代测序技术鉴定出四种新型 KIR 等位基因 KIR3DL1*0010120、KIR3DS1*01315、KIR3DL3*0020703 和 KIR2DL4*0010310。
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引用次数: 0
The full-length genomic sequence of the HLA-G*01:19 allele HLA-G*01:19 等位基因的全长基因组序列。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-16 DOI: 10.1111/tan.15654
Song Wei Yuan, LiXin Li, Wei Tian

Full genomic sequence shows HLA-G*01:19 differs from HLA-G*01:04:01:01 only at position 99 in exon 2.

全基因组序列显示，HLA-G*01:19 与 HLA-G*01:04:01:01 仅在外显子 2 的第 99 位不同。
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引用次数: 0
The novel HLA-A*02:1146 allele, identified by Sanger dideoxy nucleotide sequencing in a Chinese individual 通过桑格双脱氧核苷酸测序在一名中国人身上发现的新型 HLA-A*02:1146 等位基因。
IF 5.9 4区 医学 Q2 CELL BIOLOGY
HLA
Pub Date : 2024-08-16 DOI: 10.1111/tan.15576
Ying Xu, Ya-ping Xie, Lin An, Ye-mo Li, Peng-fei Shi

HLA-A*02:1146 differs from HLA-A*02:01:01:01 by one nucleotide in exon 1.

HLA-A*02:1146 与 HLA-A*02:01:01:01 在外显子 1 中有一个核苷酸不同。
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引用次数: 0
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