The HLA-C*01:274 allele differs from HLA-C*01:02:01:01 by one nucleotide substitution in codon 240 in exon 4.
The HLA-C*01:274 allele differs from HLA-C*01:02:01:01 by one nucleotide substitution in codon 240 in exon 4.
HLA-DQA1*03:75 differs from HLA-DQA1*03:02:01:01 by a single non-synonymous nucleotide substitution in exon 2.
Sequence confirmations of 175 HLA class I and II alleles in the IPD-IMGT/HLA Database.
HLA-DRB3*02:209 is identical to HLA-DRB3*02:02:01:01 except for a single nucleotide substitution in exon 4.
The novel allele HLA-B*51:413 differs from HLA-B*51:92:02 by one nucleotide substitution in exon 3.
The novel HLA-A*33:01:21 allele, first described in a potential bone marrow donor from Brazil.
Pollock, NR, Farias, TDJ, Kichula, KM, et al. The 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes. HLA. 2024; 103(6):e15568. doi:10.1111/tan.15568
In the article, the Abstract section was inadvertently removed. The Abstract should read:
Abstract
A fundamental endeavor of the International Histocompatibility and Immunogenetics Workshop (IHIW) was assembling a collection of DNA samples homozygous through the MHC genomic region. This collection proved invaluable for assay development in the histocompatibility and immunogenetics field, for generating the human reference genome, and furthered our understanding of MHC diversity. Defined by their HLA-A, -B, -C and -DRB1 alleles, the combined frequency of the haplotypes from these individuals is ~20% in Europe. Thus, a significant proportion of MHC haplotypes, both common and rare throughout the world, and including many associated with disease, are not yet represented. In this workshop component, we are collecting the next generation of MHC-homozygous samples, to expand, diversify and modernize this critical community resource that has been foundational to the field. We asked laboratories worldwide to identify samples homozygous through all HLA class I and/or HLA class II genes, or through whole-genome SNP genotyping or sequencing, to have extensive homozygosity tracts within the MHC region. The focus is non-Europeans or those having HLA haplotypes less common in Europeans. Through this effort, we have obtained samples from 537 individuals representing 294 distinct haplotypes, as determined by their HLA class I and II alleles, and an additional 50 haplotypes distinct in HLA class I or II alleles. Although we have expanded the diversity, many populations remain underrepresented, particularly from Africa, and we encourage further participation. The data will serve as a resource for investigators seeking to characterise variation across the MHC genomic region for disease and population studies.
The abstract has been added to the online version.
We apologize for this error.
The novel HLA-B*27:276 allele differs from HLA-B*27:05:02:05 by one nucleotide substitution in exon 1.
HLA-DQA1*05:112 differs from HLA-DQA1*05:05:01:01 by one nucleotide substitution in codon −7 in exon 1.
HLA-DRB1*04:379N differs from HLA-DRB1*04:01:01:01 by one nucleotide substitution in codon 4 in exon 1.
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：