Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.090
Pratik Shah, Sweety Saigal, S. N. Naik, Shrinivas N. Gadappa, Swati Kochar, Lakshmikantha G Lakshmikantha, Ravindra S. Pukale, Kishma Vinod
AntiD is a recombinant anti-D immunoglobulin approved as an immunoprophylaxis treatment in Rh-negative mothers carrying an Rh-positive fetus. This study was conducted to assess the safety and tolerability of AntiD in clinical settings. This was a prospective, multicenter, phase IV, post-marketing safety study of AntiD. The study was conducted at 29 hospitals in India as per regulatory requirements. Three hundred eligible Rh-negative women were administered a single intramuscular dose of either 150 mcg or 300 mcg AntiD within 72 hours of a sensitizing event as per the approved indication. Safety and tolerability were evaluated based on the assessment of adverse events (AEs) and serious adverse events (SAEs) reported during the study.Out of the 300 participants enrolled, 290 completed the study procedures. A total of 54 AEs and 34 treatment-emergent adverse events (TEAEs) were reported by 47 (15.7%) and 30 (10.0%) participants, respectively. Most reported TEAEs were mild, unrelated to the study drug, and were completely resolved during the study. Except for two participants with clinically significant hematological and urinalysis findings consistent with their underlying medical conditions, none of the participants exhibited abnormal clinical or laboratory parameters. Based on the assessment of the different safety parameters, AntiD administered at a dose of either 150 mcg or 300 mcg did not raise any new or significant safety concerns. The current study demonstrated that AntiD is well-tolerated and safe to use for anti-D prophylaxis as per product label indications for the prevention of Rh-isoimmunization in a clinical setting.
{"title":"Post-marketing safety evaluation of recombinant anti-rho (D) immunoglobulin for the prevention of maternal rh-isoimmunization: A prospective, multi-centre, phase IV study","authors":"Pratik Shah, Sweety Saigal, S. N. Naik, Shrinivas N. Gadappa, Swati Kochar, Lakshmikantha G Lakshmikantha, Ravindra S. Pukale, Kishma Vinod","doi":"10.18231/j.ijogr.2023.090","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.090","url":null,"abstract":"AntiD is a recombinant anti-D immunoglobulin approved as an immunoprophylaxis treatment in Rh-negative mothers carrying an Rh-positive fetus. This study was conducted to assess the safety and tolerability of AntiD in clinical settings. This was a prospective, multicenter, phase IV, post-marketing safety study of AntiD. The study was conducted at 29 hospitals in India as per regulatory requirements. Three hundred eligible Rh-negative women were administered a single intramuscular dose of either 150 mcg or 300 mcg AntiD within 72 hours of a sensitizing event as per the approved indication. Safety and tolerability were evaluated based on the assessment of adverse events (AEs) and serious adverse events (SAEs) reported during the study.Out of the 300 participants enrolled, 290 completed the study procedures. A total of 54 AEs and 34 treatment-emergent adverse events (TEAEs) were reported by 47 (15.7%) and 30 (10.0%) participants, respectively. Most reported TEAEs were mild, unrelated to the study drug, and were completely resolved during the study. Except for two participants with clinically significant hematological and urinalysis findings consistent with their underlying medical conditions, none of the participants exhibited abnormal clinical or laboratory parameters. Based on the assessment of the different safety parameters, AntiD administered at a dose of either 150 mcg or 300 mcg did not raise any new or significant safety concerns. The current study demonstrated that AntiD is well-tolerated and safe to use for anti-D prophylaxis as per product label indications for the prevention of Rh-isoimmunization in a clinical setting.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"20 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139270998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The baby is delivered via incisions made in the mother's abdomen and uterus during a Caesarean delivery, sometimes known as a C-section. Whether medically necessary or elective, caesarean sections have increased sharply in recent decades all throughout the world, exceeding the WHO-recommended 10-15% rate. Every effort should be taken to give cesarean sections to women in need rather than aiming to achieve a target rate, according to a 2015 WHO statement. Therefore, we must investigate the strategies that can improve CD's maternal and neonatal health condition. This study compares the outcomes for the mother and the newborn in the vacuum-assisted CD and manual CD groups.: A progressive study was conducted at Lucknow's Green cross Hospital between June 2012 and April 2018. 500 pregnant ladies took part in this study as participants. This research was approved by the institutional human ethical committee. 250 caesarean sections were performed as part of this cohort study, each with vacuum assistance utilizing a soft cup vacuum extractor on the fetal scalp and manual removal of the skull as usual with fundal compression as support. Due to the absence of uterine activity and amniotic fluid, all of the patients underwent preplanned caesarean sections. The study's findings showed that manual extraction Caesarean birth is inferior to vacuum-assisted Caesarean delivery. Additionally, it was noted that Vacuum Assisted Caesarean Delivery resulted in less uterine incision extension, estimated blood loss, and maternal discomfort. : There was no difference between Vacuum and Manual Extraction caesarean deliveries in terms of Apgar Score, the requirement for infant resuscitation, or admission to the NICU.
{"title":"Vacuum-assisted caesarean delivery assessment of maternal & fetal outcome","authors":"Manisha Agarwal, Sweekrati Solanki, Sumedha Sachau","doi":"10.18231/j.ijogr.2023.080","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.080","url":null,"abstract":": The baby is delivered via incisions made in the mother's abdomen and uterus during a Caesarean delivery, sometimes known as a C-section. Whether medically necessary or elective, caesarean sections have increased sharply in recent decades all throughout the world, exceeding the WHO-recommended 10-15% rate. Every effort should be taken to give cesarean sections to women in need rather than aiming to achieve a target rate, according to a 2015 WHO statement. Therefore, we must investigate the strategies that can improve CD's maternal and neonatal health condition. This study compares the outcomes for the mother and the newborn in the vacuum-assisted CD and manual CD groups.: A progressive study was conducted at Lucknow's Green cross Hospital between June 2012 and April 2018. 500 pregnant ladies took part in this study as participants. This research was approved by the institutional human ethical committee. 250 caesarean sections were performed as part of this cohort study, each with vacuum assistance utilizing a soft cup vacuum extractor on the fetal scalp and manual removal of the skull as usual with fundal compression as support. Due to the absence of uterine activity and amniotic fluid, all of the patients underwent preplanned caesarean sections. The study's findings showed that manual extraction Caesarean birth is inferior to vacuum-assisted Caesarean delivery. Additionally, it was noted that Vacuum Assisted Caesarean Delivery resulted in less uterine incision extension, estimated blood loss, and maternal discomfort. : There was no difference between Vacuum and Manual Extraction caesarean deliveries in terms of Apgar Score, the requirement for infant resuscitation, or admission to the NICU.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"AES-5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139273813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.095
U. Merchant, Ashwini Neelesh Desai, Gayatri Rao
Endometriosis is very common in reproductive age group. Since it is an estrogen dependent problem it is generally believed that it denotes “active ovarian function” and is “healed” after menopause. Most commonly endometrial tissue is found in ovaries resulting in the formation of chocolate cysts but it can also be found in extrapelvic sites. In this case report we will discuss endometriosis after menopause. Pulmonary endometriosis is a rare form of thoracic endometriosis. We describe a case of a 54-year-old woman with surgical menopause with recurrent episodes of haemoptysis, chest pain and dyspnea. Her Chest CT revealed multiple small pulmonary nodules. Biopsy from left lung lesion suggested endometriosis.
{"title":"De novo thoracic endometriosis in a menopausal women","authors":"U. Merchant, Ashwini Neelesh Desai, Gayatri Rao","doi":"10.18231/j.ijogr.2023.095","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.095","url":null,"abstract":"Endometriosis is very common in reproductive age group. Since it is an estrogen dependent problem it is generally believed that it denotes “active ovarian function” and is “healed” after menopause. Most commonly endometrial tissue is found in ovaries resulting in the formation of chocolate cysts but it can also be found in extrapelvic sites. In this case report we will discuss endometriosis after menopause. Pulmonary endometriosis is a rare form of thoracic endometriosis. We describe a case of a 54-year-old woman with surgical menopause with recurrent episodes of haemoptysis, chest pain and dyspnea. Her Chest CT revealed multiple small pulmonary nodules. Biopsy from left lung lesion suggested endometriosis.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139270908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.077
Khizer Hussain Afroze M, Lakshmiprabha Subhash R
To determine whether the antenatal assessment of CSA of umbilical cord variables is different in PIH compared with healthy pregnant women by using ultrasonography and to assess its relationship with gestational age.This study was conducted in the Department of Radio-diagnosis, Sri Siddhartha Medical College, among 600 (300 normal &300 PIH) pregnant women who underwent a routine prenatal gestational sonogram ranging from 28 to 39 weeks of age.There was a significant difference observed between two groups in all umbilical cord variables except umbilical artery area. Mean ± S.D of the CSA of the umbilical cord variables for each gestational age were studied in normal and PIH women.We found that the mean value of UCA and WJA was increased till 36 weeks then it decline sharply in the normal group whereas in PIH group, the mean value of UCA increases till 36 weeks then it attain plateau and the mean value of WJA increases even after 36 weeks. Our study was first of its kind to document the CSA of UC variables and their growth pattern according to gestation age, which can be used as an informational basis for both normal and PIH pregnant women.
{"title":"Umbilical cord variables in relation to gestational age by using ultrasonography in normal pregnancy and PIH women","authors":"Khizer Hussain Afroze M, Lakshmiprabha Subhash R","doi":"10.18231/j.ijogr.2023.077","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.077","url":null,"abstract":"To determine whether the antenatal assessment of CSA of umbilical cord variables is different in PIH compared with healthy pregnant women by using ultrasonography and to assess its relationship with gestational age.This study was conducted in the Department of Radio-diagnosis, Sri Siddhartha Medical College, among 600 (300 normal &300 PIH) pregnant women who underwent a routine prenatal gestational sonogram ranging from 28 to 39 weeks of age.There was a significant difference observed between two groups in all umbilical cord variables except umbilical artery area. Mean ± S.D of the CSA of the umbilical cord variables for each gestational age were studied in normal and PIH women.We found that the mean value of UCA and WJA was increased till 36 weeks then it decline sharply in the normal group whereas in PIH group, the mean value of UCA increases till 36 weeks then it attain plateau and the mean value of WJA increases even after 36 weeks. Our study was first of its kind to document the CSA of UC variables and their growth pattern according to gestation age, which can be used as an informational basis for both normal and PIH pregnant women.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"36 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139272497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.087
Eppalla Sravani, Janaki Vellanki
: Comparative study of Dydrogesterone versus oral sustained release micronized hydroxy-progesterone for support of luteal phase.: A randomized controlled trial, performed from March 2022 to April 2023. 200 women between 18–40 years of age attending infertility OPD at Gandhi hospital were enrolled in this study. Subjects were randomized and were given either oral dydrogesterone or oral sustained release micronized hydroxy-progesterone. Statistical analysis was done accordingly.In the present study, oral dydrogesterone was demonstrated to be superior than sustained release micronized hydroxy-progesterone, with UPT positive rates being 83% and 30% respectively. Dydrogesterone given orally was tolerated well with similar safety profile to sustained release micronized hydroxy-progesterone.Our study results depicted the use of dydrogesterone to be effective when compared to oral sustained release micronized hydroxy-progesterone in terms of luteal phase support. Dydrogesterone is hailed to be superior in regards of positive pregnancy rates in the current study.
{"title":"Marvel drug for infertility!!","authors":"Eppalla Sravani, Janaki Vellanki","doi":"10.18231/j.ijogr.2023.087","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.087","url":null,"abstract":": Comparative study of Dydrogesterone versus oral sustained release micronized hydroxy-progesterone for support of luteal phase.: A randomized controlled trial, performed from March 2022 to April 2023. 200 women between 18–40 years of age attending infertility OPD at Gandhi hospital were enrolled in this study. Subjects were randomized and were given either oral dydrogesterone or oral sustained release micronized hydroxy-progesterone. Statistical analysis was done accordingly.In the present study, oral dydrogesterone was demonstrated to be superior than sustained release micronized hydroxy-progesterone, with UPT positive rates being 83% and 30% respectively. Dydrogesterone given orally was tolerated well with similar safety profile to sustained release micronized hydroxy-progesterone.Our study results depicted the use of dydrogesterone to be effective when compared to oral sustained release micronized hydroxy-progesterone in terms of luteal phase support. Dydrogesterone is hailed to be superior in regards of positive pregnancy rates in the current study.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"10 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139271542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.074
R. Mondal, Mouli Nandi, Priyadarshi Mandal
Loss of normal ovarian function before the age of 40 characterizes primary ovarian insufficiency (POI), sometimes called premature ovarian failure or early menopause. Many women all around the globe deal with this serious reproductive health issue. The purpose of this study is to provide a broad perspective on how to identify and treat primary ovarian insufficiency. Clinical symptoms, hormone profiles, and ovarian imaging all play a role in making a diagnosis of POI. Genetic predisposition, autoimmune disease, and medical intervention are all possible origins. Counseling and treatment techniques for afflicted women can only be used when a timely and correct diagnosis has been made. Hormone replacement treatment (HRT) for symptom alleviation, avoidance of long-term consequences including osteoporosis and cardiovascular disease, and preservation of fertility are all part of the management of postmenopausal irritability (POI). To reduce the severity of menopausal symptoms and safeguard bone health, oestrogen replacement treatment is needed. HRT selection should be patient-specific, taking into account factors like as age, co-morbidities, and individual preferences. If a young woman is diagnosed with POI and she wants to have children in the future, she and her doctor should talk about fertility preservation strategies such oocyte or ovarian tissue cryopreservation. The latest treatments and possible revolutionary methods to POI management are also discussed in this overview. Stem cell therapy, ovarian tissue transplantation, and hormone manipulation are all examples of such unproven methods. While these treatments are still in their infancy, they show promise for the future of POI management. In conclusion, this review article gives a comprehensive, up-to-date explanation of how primary ovarian insufficiency is diagnosed and treated. Early detection, proper counselling, and individualised treatment plans are emphasised for afflicted females. The reproductive and overall health results of these people may be improved with a deeper knowledge of the processes producing POI and the development of more effective medicines.
40 岁前丧失正常卵巢功能是原发性卵巢功能不全（POI）的特征，有时也称为卵巢早衰或更年期提前。全球许多妇女都面临着这一严重的生殖健康问题。本研究的目的是为如何识别和治疗原发性卵巢功能不全提供一个广阔的视角。临床症状、激素水平和卵巢造影在诊断原发性卵巢功能不全中都起着重要作用。遗传易感性、自身免疫性疾病和医疗干预都是可能的起源。只有及时做出正确诊断，才能为患病妇女提供咨询和治疗技术。激素替代疗法（HRT）可减轻症状，避免骨质疏松症和心血管疾病等长期后果，并可保留生育能力，这些都是绝经后烦躁症（POI）治疗方法的一部分。为了减轻更年期症状的严重程度并保护骨骼健康，需要进行雌激素替代治疗。雌激素替代疗法的选择应根据患者的具体情况而定，并考虑到年龄、并发症和个人偏好等因素。如果一名年轻女性被诊断出患有 POI，并且她希望将来有孩子，那么她和她的医生就应该讨论生育力保存策略，如卵母细胞或卵巢组织冷冻保存。本概述还将讨论 POI 治疗的最新疗法和可能的革命性方法。干细胞疗法、卵巢组织移植和激素操作都是未经证实的方法。虽然这些疗法仍处于起步阶段，但它们为 POI 治疗的未来带来了希望。总之，这篇综述文章对如何诊断和治疗原发性卵巢功能不全进行了全面、最新的解释。文章强调了对患病女性的早期检测、适当咨询和个性化治疗方案。随着对原发性卵巢功能不全产生过程的深入了解和更有效药物的开发，这些患者的生殖和整体健康状况可能会得到改善。
{"title":"Primary ovarian insufficiency- An overview: Part 2 diagnosis and management","authors":"R. Mondal, Mouli Nandi, Priyadarshi Mandal","doi":"10.18231/j.ijogr.2023.074","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.074","url":null,"abstract":"Loss of normal ovarian function before the age of 40 characterizes primary ovarian insufficiency (POI), sometimes called premature ovarian failure or early menopause. Many women all around the globe deal with this serious reproductive health issue. The purpose of this study is to provide a broad perspective on how to identify and treat primary ovarian insufficiency. Clinical symptoms, hormone profiles, and ovarian imaging all play a role in making a diagnosis of POI. Genetic predisposition, autoimmune disease, and medical intervention are all possible origins. Counseling and treatment techniques for afflicted women can only be used when a timely and correct diagnosis has been made. Hormone replacement treatment (HRT) for symptom alleviation, avoidance of long-term consequences including osteoporosis and cardiovascular disease, and preservation of fertility are all part of the management of postmenopausal irritability (POI). To reduce the severity of menopausal symptoms and safeguard bone health, oestrogen replacement treatment is needed. HRT selection should be patient-specific, taking into account factors like as age, co-morbidities, and individual preferences. If a young woman is diagnosed with POI and she wants to have children in the future, she and her doctor should talk about fertility preservation strategies such oocyte or ovarian tissue cryopreservation. The latest treatments and possible revolutionary methods to POI management are also discussed in this overview. Stem cell therapy, ovarian tissue transplantation, and hormone manipulation are all examples of such unproven methods. While these treatments are still in their infancy, they show promise for the future of POI management. In conclusion, this review article gives a comprehensive, up-to-date explanation of how primary ovarian insufficiency is diagnosed and treated. Early detection, proper counselling, and individualised treatment plans are emphasised for afflicted females. The reproductive and overall health results of these people may be improved with a deeper knowledge of the processes producing POI and the development of more effective medicines.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"95 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139273103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.076
Porkodi Rabindran, Tamilarasi S, Kanimozhi K, H. T. Lalthanthuami
: Menstrual cups are a better alternative for menstrual hygiene but usage among girls and women is limited due to lack of popularity. The purpose of this study is to assess the usage of menstrual cup and its determinants among young women in health profession.: This is a cross-sectional analytical study designed to collect data among 370 young women who fulfilled the selection criteria using a cluster sampling method. The objectives of the study were assessed with a self-administered questionnaire. The data were analyzed using descriptive (frequency, percentage, mean, and standard deviation) and inferential statistics (chi-square). All statistical analysis was carried out at a 5% level of significance.: Among 370 young women only 29 (7.8%) use a menstrual cup, nearly 90% of them use it because it is comfortable, non-allergic, convenient during travel, and enables free movement. Only 8 (2.2%) have used it earlier but not presently, about 75% of them stopped because of difficulty in insertion. While 333 (90%) of young women have never used a menstrual cup, about 70% presumed menstrual cup insertion would be difficult and uncomfortable. : Young women despite being in the health profession and knowing about menstrual cups do not use them. This highlights the need for efforts to promote awareness regarding the availability and utilization of menstrual cups to empower girls and women in maintaining menstrual hygiene.
{"title":"Assess the usage pattern of menstrual cups and its determinants among young health professionals at a tertiary hospital in Puducherry","authors":"Porkodi Rabindran, Tamilarasi S, Kanimozhi K, H. T. Lalthanthuami","doi":"10.18231/j.ijogr.2023.076","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.076","url":null,"abstract":": Menstrual cups are a better alternative for menstrual hygiene but usage among girls and women is limited due to lack of popularity. The purpose of this study is to assess the usage of menstrual cup and its determinants among young women in health profession.: This is a cross-sectional analytical study designed to collect data among 370 young women who fulfilled the selection criteria using a cluster sampling method. The objectives of the study were assessed with a self-administered questionnaire. The data were analyzed using descriptive (frequency, percentage, mean, and standard deviation) and inferential statistics (chi-square). All statistical analysis was carried out at a 5% level of significance.: Among 370 young women only 29 (7.8%) use a menstrual cup, nearly 90% of them use it because it is comfortable, non-allergic, convenient during travel, and enables free movement. Only 8 (2.2%) have used it earlier but not presently, about 75% of them stopped because of difficulty in insertion. While 333 (90%) of young women have never used a menstrual cup, about 70% presumed menstrual cup insertion would be difficult and uncomfortable. : Young women despite being in the health profession and knowing about menstrual cups do not use them. This highlights the need for efforts to promote awareness regarding the availability and utilization of menstrual cups to empower girls and women in maintaining menstrual hygiene.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"37 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139275875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.092
Manish R Pandya, Nehal Manish Pandya, Varsha Narayanan, Kishan S Adroja, Vaishvi C Patel
This observational study aimed at evaluating the effects of Ovamystic in groups of women with menstrual irregularities in Polycystic Ovary Syndrome (PCOS), treated at Mahavir Hospital and Manish IVF Center Surendranagar, Gujarat. : The study involved 126 normal weight or overweight PCOS patients aged 18 to 30 years, with menstrual irregularity and anovulation > 12 months. Patients were administered orally chewable tablets of Ovamystic (myo-inositol 1100mg + D-chiro-inositol 27.6mg + alpha-lactalbumin 50mg + chromium picolinate 400mcg + vitamin D2 400IU) twice daily for 6 months. The primary outcome was measured in terms of certain parameters like changes in body mass index (BMI), change in ovarian volume, and change in frequency and duration of menstrual cycle (M-SCORE). Alpha-lactalbumin is effective in increasing myo-inositol intestinal absorption, which is very useful in reducing the therapeutic failure of myo-inositol in some patients (inositol resistant subjects).: Recovery was general, and its relevance was higher when the starting point was further away from the normal range. The most important results with Ovamystic were obtained in correcting the menstrual irregularity, and also decreasing ovarian volume and BMI. No significant adverse effects were detected in this group of patients, and Ovamystic had good tolerability and compliance. This observational study demonstrated that Ovamystic improves important parameters in PCOS patients characterized by different metabolic profiles like BMI, menstrual irregularities, and ovarian volume.
{"title":"Observational study of usage of a combination of inositols with alpha-lactalbumin (Ovamystic) in the treatment of menstrual irregularity in PCOS","authors":"Manish R Pandya, Nehal Manish Pandya, Varsha Narayanan, Kishan S Adroja, Vaishvi C Patel","doi":"10.18231/j.ijogr.2023.092","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.092","url":null,"abstract":"This observational study aimed at evaluating the effects of Ovamystic in groups of women with menstrual irregularities in Polycystic Ovary Syndrome (PCOS), treated at Mahavir Hospital and Manish IVF Center Surendranagar, Gujarat. : The study involved 126 normal weight or overweight PCOS patients aged 18 to 30 years, with menstrual irregularity and anovulation > 12 months. Patients were administered orally chewable tablets of Ovamystic (myo-inositol 1100mg + D-chiro-inositol 27.6mg + alpha-lactalbumin 50mg + chromium picolinate 400mcg + vitamin D2 400IU) twice daily for 6 months. The primary outcome was measured in terms of certain parameters like changes in body mass index (BMI), change in ovarian volume, and change in frequency and duration of menstrual cycle (M-SCORE). Alpha-lactalbumin is effective in increasing myo-inositol intestinal absorption, which is very useful in reducing the therapeutic failure of myo-inositol in some patients (inositol resistant subjects).: Recovery was general, and its relevance was higher when the starting point was further away from the normal range. The most important results with Ovamystic were obtained in correcting the menstrual irregularity, and also decreasing ovarian volume and BMI. No significant adverse effects were detected in this group of patients, and Ovamystic had good tolerability and compliance. This observational study demonstrated that Ovamystic improves important parameters in PCOS patients characterized by different metabolic profiles like BMI, menstrual irregularities, and ovarian volume.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"BME-26 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139275911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-15DOI: 10.18231/j.ijogr.2023.079
Aparajita Phukan Baruah
: Effective menstrual hygiene is vital to the health, wellbeing, dignity, empowerment, mobility and productivity of girls and women. The inadequate knowledge and improper practice of menstrual hygiene among various age group of girls and women may affect their reproductive health.A descriptive study was carried out with the objectives to assess the knowledge and practice on menstrual hygiene and to assess the significant association between selected Demographic variables with knowledge and practice among the girl students of Balika Vidya Mandir School, Digboi, Tinsukia, Assam. The study was conducted in Balika Vidya Mandir School, Digboi, Tinsukia, Assam, among 60 girl students selected by simple random sampling technique. A self structured questionnaire and a checklist was used to assess the knowledge and practice on menstrual hygiene. Both descriptive and inferential statistics were used to find out the result of the study.Findings related to knowledge revealed that majority 82% (49) girl students had moderately adequate knowledge, 10% (6) had inadequate knowledge and only 8% (5) had adequate knowledge on menstrual hygiene.Findings related to practice revealed that majority 75% (45) girl students had moderately adequate practice, 17% (10) had inadequate practice and only 8% (5) had adequate practice on menstrual hygiene. Findings related to association between knowledge and selected demographic variables revealed that there is significant association between knowledge and age of girl students and family income. Findings related to association between knowledge and selected demographic variables revealed that there is significant association between practice and family income and religion. From the study findings it can be inferred that knowledge and practice of girl students of the school have moderately adequate. Therefore more emphasis should be given on providing knowledge regarding menstrual hygiene among the girl students.
{"title":"Knowledge and practice on menstrual hygiene among girl students of Balika Vidya Mandir School, Digboi, Tinsukia, Assam","authors":"Aparajita Phukan Baruah","doi":"10.18231/j.ijogr.2023.079","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.079","url":null,"abstract":": Effective menstrual hygiene is vital to the health, wellbeing, dignity, empowerment, mobility and productivity of girls and women. The inadequate knowledge and improper practice of menstrual hygiene among various age group of girls and women may affect their reproductive health.A descriptive study was carried out with the objectives to assess the knowledge and practice on menstrual hygiene and to assess the significant association between selected Demographic variables with knowledge and practice among the girl students of Balika Vidya Mandir School, Digboi, Tinsukia, Assam. The study was conducted in Balika Vidya Mandir School, Digboi, Tinsukia, Assam, among 60 girl students selected by simple random sampling technique. A self structured questionnaire and a checklist was used to assess the knowledge and practice on menstrual hygiene. Both descriptive and inferential statistics were used to find out the result of the study.Findings related to knowledge revealed that majority 82% (49) girl students had moderately adequate knowledge, 10% (6) had inadequate knowledge and only 8% (5) had adequate knowledge on menstrual hygiene.Findings related to practice revealed that majority 75% (45) girl students had moderately adequate practice, 17% (10) had inadequate practice and only 8% (5) had adequate practice on menstrual hygiene. Findings related to association between knowledge and selected demographic variables revealed that there is significant association between knowledge and age of girl students and family income. Findings related to association between knowledge and selected demographic variables revealed that there is significant association between practice and family income and religion. From the study findings it can be inferred that knowledge and practice of girl students of the school have moderately adequate. Therefore more emphasis should be given on providing knowledge regarding menstrual hygiene among the girl students.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139273012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: To assess the role of extended first trimester screening (EFTS) in early detection and management of preeclampsia.: A total of 501 parturients (aged 18-49 years; GA 11-13 weeks) underwent ETFS quadruple test that included age, sonographic data (CRL, Nuchal Tube (NT), ductus venosus PI) and biochemical tests (b-hCG, Alpha-fetoprotein, PLGF and PAPP-A for Trisomy 21, 18 and 13) levels. All the women were followed up for preeclampsia. Role of independent as well as combined ETFS predictors was assessed for prediction of preeclampsia employing independent samples ‘t’- and Fisher exact tests. ROC analysis was performed for continuous predictors significantly associated with preeclampsia risk. Results have been depicted in terms of sensitivity, specificity, positive and negative predictive values of different ETFS risk predictors.Meanage of women was 28.07±4.77 years. Quadruple test was negative in 422 (84.2%). It was positive for Down’s syndrome/T21 in 23 (4.6%), T21 with increased PLGF in 8 (1.6%) and increased PLGF only in 48 (9.6%) cases. A total of 14 (2.8%) women developed preeclampsia. Older age, T21 risk, PLGF risk and any quadruple test abnormality were significantly associated with preeclampsia (p<0.05). On ROC analysis, the area under the curve value of age for prediction of preeclampsia was 0.940. Among different EFTS risks, age had maximum sensitivity (100%) and specificity (88.3%). Overall quadruple test was 71.4% sensitive and 85.8% specific in prediction of preeclampsia.: EFTS was a useful strategy for reducing the burden of preeclampsia.
{"title":"Role of extended first trimester screening (EFTS) in screening of aneuploidy and prediction of pre-eclampsia","authors":"Anima Anjani, Gunjan Rai, Gargi Vikas Sharma, Shivani Rajouraya, Sunil Kumar Chaudhary","doi":"10.18231/j.ijogr.2023.085","DOIUrl":"https://doi.org/10.18231/j.ijogr.2023.085","url":null,"abstract":": To assess the role of extended first trimester screening (EFTS) in early detection and management of preeclampsia.: A total of 501 parturients (aged 18-49 years; GA 11-13 weeks) underwent ETFS quadruple test that included age, sonographic data (CRL, Nuchal Tube (NT), ductus venosus PI) and biochemical tests (b-hCG, Alpha-fetoprotein, PLGF and PAPP-A for Trisomy 21, 18 and 13) levels. All the women were followed up for preeclampsia. Role of independent as well as combined ETFS predictors was assessed for prediction of preeclampsia employing independent samples ‘t’- and Fisher exact tests. ROC analysis was performed for continuous predictors significantly associated with preeclampsia risk. Results have been depicted in terms of sensitivity, specificity, positive and negative predictive values of different ETFS risk predictors.Meanage of women was 28.07±4.77 years. Quadruple test was negative in 422 (84.2%). It was positive for Down’s syndrome/T21 in 23 (4.6%), T21 with increased PLGF in 8 (1.6%) and increased PLGF only in 48 (9.6%) cases. A total of 14 (2.8%) women developed preeclampsia. Older age, T21 risk, PLGF risk and any quadruple test abnormality were significantly associated with preeclampsia (p<0.05). On ROC analysis, the area under the curve value of age for prediction of preeclampsia was 0.940. Among different EFTS risks, age had maximum sensitivity (100%) and specificity (88.3%). Overall quadruple test was 71.4% sensitive and 85.8% specific in prediction of preeclampsia.: EFTS was a useful strategy for reducing the burden of preeclampsia.","PeriodicalId":13288,"journal":{"name":"Indian Journal of Obstetrics and Gynecology Research","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139274267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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