Pub Date : 2023-09-01DOI: 10.56042/ijeb.v61i09.3784
{"title":"Hepatoprotective activity of Trianthema portulacastrum against lipopolysaccharide/ D-galactosamine- induced hepatotoxicity in mice","authors":"","doi":"10.56042/ijeb.v61i09.3784","DOIUrl":"https://doi.org/10.56042/ijeb.v61i09.3784","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47800955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.56042/ijeb.v61i09.3872
{"title":"Development of recombinant sialidase (NanH) protein-based Indirect-ELISA for epidemiological survey of anti-Pasteurella multocida antibodies in bovines","authors":"","doi":"10.56042/ijeb.v61i09.3872","DOIUrl":"https://doi.org/10.56042/ijeb.v61i09.3872","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42575378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.56042/ijeb.v61i09.1547
{"title":"The Effect of KATP Openers and Blockers on AKT and mTOR mRNA Levels in the Hippocampus and Cortex of Rats with Penicillin-Induced Epilepsy","authors":"","doi":"10.56042/ijeb.v61i09.1547","DOIUrl":"https://doi.org/10.56042/ijeb.v61i09.1547","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47296420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.56042/ijeb.v61i09.5115
{"title":"Determination of lithium toxicity by apoptosis and different biomarkers on Carassius auratus (Linn.) tissues","authors":"","doi":"10.56042/ijeb.v61i09.5115","DOIUrl":"https://doi.org/10.56042/ijeb.v61i09.5115","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44921030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.56042/ijeb.v61i09.5188
{"title":"Correlation between musculoskeletal ultrasound signs of gouty arthritis and disease activity","authors":"","doi":"10.56042/ijeb.v61i09.5188","DOIUrl":"https://doi.org/10.56042/ijeb.v61i09.5188","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48125480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.56042/ijeb.v61i09.3875
{"title":"Downregulation of Wnt/β-catenin self-renewal pathway in cervical cancer cells by polyphenolic compounds","authors":"","doi":"10.56042/ijeb.v61i09.3875","DOIUrl":"https://doi.org/10.56042/ijeb.v61i09.3875","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48046717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-31DOI: 10.56042/ijeb.v61i08.3878
Limin Yin, Chaohong Shi, Zhong-xiang Zhang, Wensheng Wang, Ming Li
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors, and effective therapeutic interventions for PDAC are limited. While Corynoxine (Cory) and its isomer Cory B have been identified as autophagy inducers in neuronal cells, it remains unclear whether they exert a therapeutic effect on PDAC. Here, we performed cell counting kit-8 (CCK8), colony formation, 5-Ethynyl-2′-deoxyuridine (EDU) staining, TUNEL, and flow cytometry assays to evaluate the effects of Cory on PDAC. Western blotting was conducted to analyze the protein expression levels. We showed that Cory and Cory B enhanced cell growth arrest and pro-apoptotic effects of gemcitabine (Gem) on Gem-resistant Panc-1 cells. Mechanistic studies revealed that increased production of reactive oxygen species (ROS) and p38 activation were closely associated with Cory and Cory B-induced cell death. Pretreatment with ROS scavenger N-acetylcysteine blocked Cory and Cory B-induced cell death. Moreover, p38 inhibitor SB203580 prevented cell death induced by Cory and Cory B. Overall, Cory and Cory B increase the sensitivity of Gem-resistant Panc-1 cells to Gem through the activation of ROS-dependent p38 signaling pathway. Our results indicate that Cory and Cory B might be potential approaches for PDAC therapy.
{"title":"Corynoxine and corynoxine B enhance the antitumor activity of gemcitabine in Panc-1 cells via ROS-p38 signaling pathway","authors":"Limin Yin, Chaohong Shi, Zhong-xiang Zhang, Wensheng Wang, Ming Li","doi":"10.56042/ijeb.v61i08.3878","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.3878","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors, and effective therapeutic interventions for PDAC are limited. While Corynoxine (Cory) and its isomer Cory B have been identified as autophagy inducers in neuronal cells, it remains unclear whether they exert a therapeutic effect on PDAC. Here, we performed cell counting kit-8 (CCK8), colony formation, 5-Ethynyl-2′-deoxyuridine (EDU) staining, TUNEL, and flow cytometry assays to evaluate the effects of Cory on PDAC. Western blotting was conducted to analyze the protein expression levels. We showed that Cory and Cory B enhanced cell growth arrest and pro-apoptotic effects of gemcitabine (Gem) on Gem-resistant Panc-1 cells. Mechanistic studies revealed that increased production of reactive oxygen species (ROS) and p38 activation were closely associated with Cory and Cory B-induced cell death. Pretreatment with ROS scavenger N-acetylcysteine blocked Cory and Cory B-induced cell death. Moreover, p38 inhibitor SB203580 prevented cell death induced by Cory and Cory B. Overall, Cory and Cory B increase the sensitivity of Gem-resistant Panc-1 cells to Gem through the activation of ROS-dependent p38 signaling pathway. Our results indicate that Cory and Cory B might be potential approaches for PDAC therapy.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46626385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-31DOI: 10.56042/ijeb.v61i08.4375
{"title":"Outcomes of wuhan, alpha, delta, omicron and other variants in severe acute respiratory syndrome coronavirus-2","authors":"","doi":"10.56042/ijeb.v61i08.4375","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4375","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45456670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-31DOI: 10.56042/ijeb.v61i08.4373
Keke Wu, Yun Luo, J. Qin, Xiaxia Xu
Sepsis is one of the primary causes of mortality in the world. When the sepsis develops into acute organ dysfunction it is considered severe. Severe sepsis increases the economic burden by means of potential treatment for inflammatory responses and multiple organ failure. Several factors, including age, inappropriate use of antibiotics, comorbidities, multiple organ dysfunction, and site of infection, are considered to increase mortality risk in severe septic patients. This systematic review analyses various factors influencing mortality in ICU-hospitalized patients with severe sepsis. A systematic search for relevant articles up to September 2022 was carried out on 6 electronic databases, including Scopus, MEDLINE, PubMed, ScienceDirect, Embase and Google Scholar. Of 1078 articles, only nine studies were reviewed after meeting the inclusion criteria. Meta-analysis of three studies reveal significantly more fatality in older patients than the younger (OR; 2.28: 1.65, 3.15: 95% CI: I 2 = 11%, P <0.00001). The number of organ failure also significantly influences the mortality with the mortality rate being higher for patients with ≥4 organ failures (OR; 0.19: 0.11, 0.30: 95% CI: I 2 = 93%: P <0.00001). The mortality rates for hospital-acquired, community-acquired and ICU-acquired infections were 0.41 (95% CI; 0.18, 0.69), 0.40 (95% CI; 0.20, 0.63), and 0.42 (95% CI; 0.44, 0.53), respectively. Gender shows no significant difference on mortality rates (OR; 1.05: 0.95, 1.16: 95% CI: I 2 = 27%: p = 0.35). Age, the number of organ failures, and the acquisition sites seem to significantly influence the mortality, while gender has an insignificant influence on the mortality of ICU-admitted severe septic patients.
{"title":"Factors influencing mortality in ICU hospitalized patients with severe sepsis: A systematic review and meta-analysis","authors":"Keke Wu, Yun Luo, J. Qin, Xiaxia Xu","doi":"10.56042/ijeb.v61i08.4373","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4373","url":null,"abstract":"Sepsis is one of the primary causes of mortality in the world. When the sepsis develops into acute organ dysfunction it is considered severe. Severe sepsis increases the economic burden by means of potential treatment for inflammatory responses and multiple organ failure. Several factors, including age, inappropriate use of antibiotics, comorbidities, multiple organ dysfunction, and site of infection, are considered to increase mortality risk in severe septic patients. This systematic review analyses various factors influencing mortality in ICU-hospitalized patients with severe sepsis. A systematic search for relevant articles up to September 2022 was carried out on 6 electronic databases, including Scopus, MEDLINE, PubMed, ScienceDirect, Embase and Google Scholar. Of 1078 articles, only nine studies were reviewed after meeting the inclusion criteria. Meta-analysis of three studies reveal significantly more fatality in older patients than the younger (OR; 2.28: 1.65, 3.15: 95% CI: I 2 = 11%, P <0.00001). The number of organ failure also significantly influences the mortality with the mortality rate being higher for patients with ≥4 organ failures (OR; 0.19: 0.11, 0.30: 95% CI: I 2 = 93%: P <0.00001). The mortality rates for hospital-acquired, community-acquired and ICU-acquired infections were 0.41 (95% CI; 0.18, 0.69), 0.40 (95% CI; 0.20, 0.63), and 0.42 (95% CI; 0.44, 0.53), respectively. Gender shows no significant difference on mortality rates (OR; 1.05: 0.95, 1.16: 95% CI: I 2 = 27%: p = 0.35). Age, the number of organ failures, and the acquisition sites seem to significantly influence the mortality, while gender has an insignificant influence on the mortality of ICU-admitted severe septic patients.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48183793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-31DOI: 10.56042/ijeb.v61i08.4376
Yajun Zhang, Tiansheng Yin, Yang Liu, Jiajun Xiao
Gastric cancer (also called stomach cancer) is the 5 th most common cancer the human population suffer from, particularly in East Asia. For effective prevention, it is important to find biomarkers for early-stage diagnosis and prognosis. Further, finding the risk factors that are associated with undifferentiated early gastric cancer is the utmost required. Here, we explored the clinicopathological characteristics of undifferentiated early gastric cancer (EGC) in the elderly, and the risk factors for lymph node metastasis. A total of 187 elderly patients with undifferentiated EGC were selected as subjects, whose clinical data were analyzed retrospectively. They were divided into lymph node metastasis and non-lymph node metastasis groups, and the risk factors for lymph node metastasis were analyzed by univariate and multivariate logistic regression analyses. A nomogram model was established to predict the risk of lymph node metastasis, and then validated. Lymph node metastasis was detected in 32 (17.11%) of the 187 cases. Univariate analysis showed that tumor diameter, depth of invasion, vascular tumor thrombus and local ulcer affected lymph node metastasis ( P <0.05). Multivariate logistic regression analysis revealed that tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer were independent risk factors ( P <0.05). The nomogram model was constructed based on the independent risk factors, and its concordance index and area under the receiver operating characteristic curve were 0.756 (95%CI: 0.684-0.830) and 0.758 (95%CI: 0.701-0.815), respectively. Calibration curve and model calibration curve suggested that the predicted probability of the model was consistent with the actual one, indicating high accuracy. Lymph node metastasis of the elderly with undifferentiated EGC is affected by many factors, among which tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer are independent risk factors.
{"title":"Utility of risk prediction nomogram for lymph node metastasis in the elderly with undifferentiated early gastric cancer","authors":"Yajun Zhang, Tiansheng Yin, Yang Liu, Jiajun Xiao","doi":"10.56042/ijeb.v61i08.4376","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4376","url":null,"abstract":"Gastric cancer (also called stomach cancer) is the 5 th most common cancer the human population suffer from, particularly in East Asia. For effective prevention, it is important to find biomarkers for early-stage diagnosis and prognosis. Further, finding the risk factors that are associated with undifferentiated early gastric cancer is the utmost required. Here, we explored the clinicopathological characteristics of undifferentiated early gastric cancer (EGC) in the elderly, and the risk factors for lymph node metastasis. A total of 187 elderly patients with undifferentiated EGC were selected as subjects, whose clinical data were analyzed retrospectively. They were divided into lymph node metastasis and non-lymph node metastasis groups, and the risk factors for lymph node metastasis were analyzed by univariate and multivariate logistic regression analyses. A nomogram model was established to predict the risk of lymph node metastasis, and then validated. Lymph node metastasis was detected in 32 (17.11%) of the 187 cases. Univariate analysis showed that tumor diameter, depth of invasion, vascular tumor thrombus and local ulcer affected lymph node metastasis ( P <0.05). Multivariate logistic regression analysis revealed that tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer were independent risk factors ( P <0.05). The nomogram model was constructed based on the independent risk factors, and its concordance index and area under the receiver operating characteristic curve were 0.756 (95%CI: 0.684-0.830) and 0.758 (95%CI: 0.701-0.815), respectively. Calibration curve and model calibration curve suggested that the predicted probability of the model was consistent with the actual one, indicating high accuracy. Lymph node metastasis of the elderly with undifferentiated EGC is affected by many factors, among which tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer are independent risk factors.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44634707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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