Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.2213
{"title":"Association of FokI polymorphism of vitamin D receptor gene with vitamin D and parathyroid hormone levels in stage IV-V chronic kidney disease patients","authors":"","doi":"10.56042/ijeb.v61i07.2213","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.2213","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41843779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.2211
{"title":"Transcriptional reprogramming under vancomycin pressure in Staphylococcus aureus","authors":"","doi":"10.56042/ijeb.v61i07.2211","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.2211","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46477374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.3117
{"title":"Effect of exogenous pulmonary surfactant on infectious pneumonia, serum procalcitonin, high-sensitivity C-reactive protein and interleukin-6 in neonates","authors":"","doi":"10.56042/ijeb.v61i07.3117","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.3117","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48099745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.2826
{"title":"Machine Learning to Predict Etiology for Infectious Diseases of Classic Fever of Unknown Origin in Adults","authors":"","doi":"10.56042/ijeb.v61i07.2826","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.2826","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43309507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.2323
{"title":"Association of immune status with haematology and inflammatory markers in treatment naïve HIV positive patients from a tertiary health care institute e HIV Positive Patients from a Tertiary Health Care Institute","authors":"","doi":"10.56042/ijeb.v61i07.2323","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.2323","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49222641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.2212
{"title":"Hypermethylation and reduced expression of lipoprotein metabolism genes ABCG1, LIPC and PLTP in Obese and Diabetic subjects: Potential risk factors for Coronary artery disease","authors":"","doi":"10.56042/ijeb.v61i07.2212","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.2212","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45309606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-28DOI: 10.56042/ijeb.v61i07.2215
{"title":"Clinical features and biochemical parameters influencing mortality in COVID-19 patients — Retrospective study from Telangana, India","authors":"","doi":"10.56042/ijeb.v61i07.2215","DOIUrl":"https://doi.org/10.56042/ijeb.v61i07.2215","url":null,"abstract":"","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46139791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.56042/ijeb.v61i06.1931
Ay ş egül Yildiz, Süleyman Emre, Ayd ı n Him
Glucagon-like peptide-1 receptors are widely expressed in the brain and its association with nitric oxide is suggestive of its role in epilepsy. In this study, we investigated the effects of exenatide, a glucagon-like peptide-1 receptor agonist, on the epileptiform activity induced by penicillin injection. The study used 72 male Wistar albino rats in 9 groups. All groups except the last group which received only exenatide, received intracortical penicillin injection to induce epileptiform activity. Exenatide was intraperitoneally injected in II-IV groups, at doses of 50, 100, 200 μ g/kg, respectively. Sodium nitroprusside (SNP) and N ω -nitro-L-arginine methyl ester (L-NAME) were injected to the V-VIII groups either alone or with exenatide. Electrocorticography was recorded for 3 h. While administration of 200 μ g/kg exenatide reduced the frequency of epileptiform activity, 50 and 100 μ g/kg doses of exenatide were not effective. When the effective dose of exenatide and the SNP were injected together the spike frequency decreased significantly. When the effective dose of exenatide was given with L-NAME spike frequency significantly decreased only between 90 and 110 min. There was no statistically significant difference in terms of latency and amplitude between the experimental groups. Exenatide had an anticonvulsant effect in penicillin-induced acute epilepsy model which is possibly via nitric oxide and include another pathway since its effect was partially blocked by L-NAME and potentiated by SNP.
{"title":"Antiepileptic effects of exenatide in penicillin induced acute epilepsy model in rats","authors":"Ay ş egül Yildiz, Süleyman Emre, Ayd ı n Him","doi":"10.56042/ijeb.v61i06.1931","DOIUrl":"https://doi.org/10.56042/ijeb.v61i06.1931","url":null,"abstract":"Glucagon-like peptide-1 receptors are widely expressed in the brain and its association with nitric oxide is suggestive of its role in epilepsy. In this study, we investigated the effects of exenatide, a glucagon-like peptide-1 receptor agonist, on the epileptiform activity induced by penicillin injection. The study used 72 male Wistar albino rats in 9 groups. All groups except the last group which received only exenatide, received intracortical penicillin injection to induce epileptiform activity. Exenatide was intraperitoneally injected in II-IV groups, at doses of 50, 100, 200 μ g/kg, respectively. Sodium nitroprusside (SNP) and N ω -nitro-L-arginine methyl ester (L-NAME) were injected to the V-VIII groups either alone or with exenatide. Electrocorticography was recorded for 3 h. While administration of 200 μ g/kg exenatide reduced the frequency of epileptiform activity, 50 and 100 μ g/kg doses of exenatide were not effective. When the effective dose of exenatide and the SNP were injected together the spike frequency decreased significantly. When the effective dose of exenatide was given with L-NAME spike frequency significantly decreased only between 90 and 110 min. There was no statistically significant difference in terms of latency and amplitude between the experimental groups. Exenatide had an anticonvulsant effect in penicillin-induced acute epilepsy model which is possibly via nitric oxide and include another pathway since its effect was partially blocked by L-NAME and potentiated by SNP.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41887199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.56042/ijeb.v61i06.1929
Deniz Ercetin, M. Sapmaz-Metin, R. D. Topuz
Ovarian activity has a complex physiology and is related to oocyte quality in women. This study investigates the effects of ovarian activity with chronic stress (CS) on behavioural parameters, estrous cycles, and ovarian follicular development in rats. Here, we examined the ovarian microenvironment against exposure to stress and to elucidate the stress-related ovarian molecular mechanisms. Twenty female Sprague-Dawley rats were divided into the control and the CS groups. The estrous cycle phases were detected by vaginal smear. Rats in the CS group were immobilized 1 h/day for 8 weeks. At the end of the experiment, all animals were subjected to behavioral tests in their metestrus phase and sacrificed on the other day (diestrus phase). The ovaries were harvested for histological analysis, blood samples were taken to measure cortisol levels. The immunoreactivities of ovarian IGF-1, AMH and Bcl-2 proteins were evaluated by immunohistochemistry. Here, we have studied CS-induced prolonged estrous cycles. We showed a lower number of developing follicles but the higher number of atretic follicles in the CS group’s ovaries. The dominant structure of ovarian histology was large interstitial glands. CS caused decreases in ovarian Bcl-2, IGF-1 and AMH immunoreactivities which have roles in follicular development. Also, anxiety was detected in CS-exposed animals. Our results showed that chronic restrainer stress can be a serious endocrine disrupter by reducing ovarian paracrine
{"title":"Effect of chronic physiological stress on rat oocyte reserve: Role of IGF-1, AMH and Bcl-2","authors":"Deniz Ercetin, M. Sapmaz-Metin, R. D. Topuz","doi":"10.56042/ijeb.v61i06.1929","DOIUrl":"https://doi.org/10.56042/ijeb.v61i06.1929","url":null,"abstract":"Ovarian activity has a complex physiology and is related to oocyte quality in women. This study investigates the effects of ovarian activity with chronic stress (CS) on behavioural parameters, estrous cycles, and ovarian follicular development in rats. Here, we examined the ovarian microenvironment against exposure to stress and to elucidate the stress-related ovarian molecular mechanisms. Twenty female Sprague-Dawley rats were divided into the control and the CS groups. The estrous cycle phases were detected by vaginal smear. Rats in the CS group were immobilized 1 h/day for 8 weeks. At the end of the experiment, all animals were subjected to behavioral tests in their metestrus phase and sacrificed on the other day (diestrus phase). The ovaries were harvested for histological analysis, blood samples were taken to measure cortisol levels. The immunoreactivities of ovarian IGF-1, AMH and Bcl-2 proteins were evaluated by immunohistochemistry. Here, we have studied CS-induced prolonged estrous cycles. We showed a lower number of developing follicles but the higher number of atretic follicles in the CS group’s ovaries. The dominant structure of ovarian histology was large interstitial glands. CS caused decreases in ovarian Bcl-2, IGF-1 and AMH immunoreactivities which have roles in follicular development. Also, anxiety was detected in CS-exposed animals. Our results showed that chronic restrainer stress can be a serious endocrine disrupter by reducing ovarian paracrine","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49136911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：