Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i2.51337
Amit Das, A. Ferdausi, Xianmin Chang, Meriel Jones
Since the ancient times, Amaryllidaceae genus Narcissus has been reported for the production of biologically important alkaloids, many of which are used as therapeutic tools for human diseases. Among them, galanthamine (Gal) has received a considerable attention for its acetylcholinesterase inhibitory activity for the treatment of early to mid-stage Alzheimer’s diseases. In this study, gas chromatography-mass spectrophotometry was used to determine the galanthamine content along with the detection of other biologically important alkaloids in dormant bulb and basal plate of two cultivated varieties of Narcissus pseudonarcissus , Carlton and Andrew’s Choice. The amount of galanthamine was higher in Carlton bulb (860 µg Gal/g) and basal plate (1254 µg Gal/g) than Andrew’s Choice bulb (674 µg Gal/g) and basal plate (1051 µg Gal/g). Non-dormant Carlton bulb was used as control, which represented the galanthamine content of 1117 µg Gal/g. Besides galanthamine, other biologically important alkaloids were detected in Carlton such as lycoramine, lycorine, lycorenine, crinamine, and pancracine; while tazettine, oxoassoanine, lycorine, and o -methyl-macronine were detected in Andrew’s Choice. Findings of this study suggest that both Narcissus cultivars could be the important sources for the isolation of naturally occurring bioactive alkaloids for their commercial availability and could be potentially used in pharmaceuticals.
{"title":"Biologically active Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton and Andrew’s Choice dormant bulbs","authors":"Amit Das, A. Ferdausi, Xianmin Chang, Meriel Jones","doi":"10.56042/ijnpr.v13i2.51337","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i2.51337","url":null,"abstract":"Since the ancient times, Amaryllidaceae genus Narcissus has been reported for the production of biologically important alkaloids, many of which are used as therapeutic tools for human diseases. Among them, galanthamine (Gal) has received a considerable attention for its acetylcholinesterase inhibitory activity for the treatment of early to mid-stage Alzheimer’s diseases. In this study, gas chromatography-mass spectrophotometry was used to determine the galanthamine content along with the detection of other biologically important alkaloids in dormant bulb and basal plate of two cultivated varieties of Narcissus pseudonarcissus , Carlton and Andrew’s Choice. The amount of galanthamine was higher in Carlton bulb (860 µg Gal/g) and basal plate (1254 µg Gal/g) than Andrew’s Choice bulb (674 µg Gal/g) and basal plate (1051 µg Gal/g). Non-dormant Carlton bulb was used as control, which represented the galanthamine content of 1117 µg Gal/g. Besides galanthamine, other biologically important alkaloids were detected in Carlton such as lycoramine, lycorine, lycorenine, crinamine, and pancracine; while tazettine, oxoassoanine, lycorine, and o -methyl-macronine were detected in Andrew’s Choice. Findings of this study suggest that both Narcissus cultivars could be the important sources for the isolation of naturally occurring bioactive alkaloids for their commercial availability and could be potentially used in pharmaceuticals.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i4.45637
{"title":"Optimization of carrageenan production from Persian Gulf algae Laurencia obtusa: Purification and rheological characterization","authors":"","doi":"10.56042/ijnpr.v13i4.45637","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i4.45637","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i4.60111
{"title":"GC-MS analysis and qualitative phytochemical screening of Aristolochia assamica, a newly discovered rare medicinal plant species of India","authors":"","doi":"10.56042/ijnpr.v13i4.60111","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i4.60111","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i3.58263
{"title":"Dactylorhiza hatagirea (D. Doon) Soo, an important medicinal herb of the Himalaya and urgent need for its conservation- A review","authors":"","doi":"10.56042/ijnpr.v13i3.58263","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i3.58263","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i1.35508
{"title":"Gynocardia odorata R. Br., a poisonous plant made edible by the Khasi tribe of Meghalaya using traditional knowledge","authors":"","doi":"10.56042/ijnpr.v13i1.35508","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i1.35508","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70703758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v12i4.35764
{"title":"Sedative and hypnotic activity of the leaves of Bijapura (Citrus medica L.)","authors":"","doi":"10.56042/ijnpr.v12i4.35764","DOIUrl":"https://doi.org/10.56042/ijnpr.v12i4.35764","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70703923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v12i4.33328
N. Verma
Advances in analytical methods and bioassay development have helped to push forward the research in natural products. Their high chemical diversity and the effects of evolutionary pressure to create biologically active molecules could be attributed to success in drug discovery. Despite the availability of modern analytical instrumentation techniques, metabolic profiling covers the identification of a selected group of metabolites. The phytochemical analysis is commonly performed using standard techniques such as thin-layer chromatography, high-performance thin-layer chromatography, high-performance liquid chromatography, gas chromatography and more recently mass spectrometry and nuclear magnetic resonance spectrometry. Two-dimensional J -resolved Nuclear Magnetic Resonance (NMR) spectra and multivariate data analysis techniques were applied to avoid low resolution and overlapping signals hampering the identification of the individual components of botanicals. On-targeted metabolomic analysis via the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) was utilised to localise compounds belonging to various chemical classes ( i.e . oxygenated fatty acids, flavonols, phenolic acids, and sinapoyl choline derivatives). Rotation planar chromatography over-pressured layer chromatography and electro planar chromatography are the other innovations. Parallel and serially coupled layers open up new avenues for the analysis of a large number of samples for high-throughput screening and very complex matrices in a natural product. Analytical strategies with applications to natural extracts and novel methods that have strong potential, regardless of how often they are used are discussed with respect to their potential applications challenges and future trends.
{"title":"Advances and trends in analytical techniques in natural product research: Challenges and future perspective","authors":"N. Verma","doi":"10.56042/ijnpr.v12i4.33328","DOIUrl":"https://doi.org/10.56042/ijnpr.v12i4.33328","url":null,"abstract":"Advances in analytical methods and bioassay development have helped to push forward the research in natural products. Their high chemical diversity and the effects of evolutionary pressure to create biologically active molecules could be attributed to success in drug discovery. Despite the availability of modern analytical instrumentation techniques, metabolic profiling covers the identification of a selected group of metabolites. The phytochemical analysis is commonly performed using standard techniques such as thin-layer chromatography, high-performance thin-layer chromatography, high-performance liquid chromatography, gas chromatography and more recently mass spectrometry and nuclear magnetic resonance spectrometry. Two-dimensional J -resolved Nuclear Magnetic Resonance (NMR) spectra and multivariate data analysis techniques were applied to avoid low resolution and overlapping signals hampering the identification of the individual components of botanicals. On-targeted metabolomic analysis via the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) was utilised to localise compounds belonging to various chemical classes ( i.e . oxygenated fatty acids, flavonols, phenolic acids, and sinapoyl choline derivatives). Rotation planar chromatography over-pressured layer chromatography and electro planar chromatography are the other innovations. Parallel and serially coupled layers open up new avenues for the analysis of a large number of samples for high-throughput screening and very complex matrices in a natural product. Analytical strategies with applications to natural extracts and novel methods that have strong potential, regardless of how often they are used are discussed with respect to their potential applications challenges and future trends.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v12i4.33755
{"title":"Mosquito larvicidal and antimicrobial activities of synthesized silver nanoparticles (AgNP) using mature fruit extract of Cestrum diurnum L.","authors":"","doi":"10.56042/ijnpr.v12i4.33755","DOIUrl":"https://doi.org/10.56042/ijnpr.v12i4.33755","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i1.52557
{"title":"Chemical composition and antimicrobial properties of the rhizome essential oil of Cyperus articulatus L. grown in Karnataka, India","authors":"","doi":"10.56042/ijnpr.v13i1.52557","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i1.52557","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.56042/ijnpr.v13i3.37833
{"title":"Antioxidant, anti-inflammatory, thrombolytic, and cytotoxic activities of Gynura nepalensis DC. and isolation of its steroid constituents","authors":"","doi":"10.56042/ijnpr.v13i3.37833","DOIUrl":"https://doi.org/10.56042/ijnpr.v13i3.37833","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：