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Aesculus indica: An ethnomedicinal, phytochemical, and pharmacological review 七叶神:民族医药、植物化学和药理学综述
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i2.4203
Som K. Madhvi, J. Iqbal, M. Younis, Himachal Pradesh. In, Himachal Pradesh
Aesculus indica , commonly known as Indian horse chestnut, is an indigenous tree of the family Sapindaceae, distributed in Nepal, India, Pakistan, and Afghanistan. As an ethnomedicine, its seeds are used to cure jaundice, chest diseases, stomach and joint pain, roots for leucorrhea, and bark for fever and anaemia. The phytochemicals of class phenolic, triterpenoid, glycoside, saponin, and fatty acid have been identified from their different parts and various biological activities such as antioxidant, anti-diabetic, hypocholesterolemic, hypoglycaemic, anti-nociceptive, anti-inflammatory, neuro-depressive, spasmolytic, immunomodulatory, anticancer, enzyme inhibitory, antimicrobial and insecticidal have been reported, which reflected its medicinal importance. However, most biological activities are on the extracts or fractions and need more in-depth study. Therefore, further research is required on the isolation, identification, and characterization of active phytochemicals from the extracts with their mechanism of pharmacological action and detailed toxicological evaluation. In this review, we aim to provide all information regarding traditional uses, morphology, phytochemistry, pharmacology, and toxicity of A. indica and address the research gaps; therefore, will provide a source of information to the researchers for further studies.
七叶树(Aesculus indica),俗称印度七叶树,是一种本土树种,分布在尼泊尔、印度、巴基斯坦和阿富汗。作为一种民族药,它的种子用于治疗黄疸,胸部疾病,胃和关节疼痛,根用于白带,树皮用于发烧和贫血。从不同部位鉴定出酚类、三萜类、糖苷类、皂苷类、脂肪酸类等植物化学物质,并报道了其抗氧化、降糖尿病、降胆固醇、降血糖、抗伤害、抗炎、神经抑制、解痉、免疫调节、抗癌、抑酶、抗菌、杀虫等多种生物活性,反映了其药用价值。然而,大多数生物活性都在提取物或馏分上,需要更深入的研究。因此,从提取物中分离、鉴定和表征活性植物化学物质,并对其药理作用机制和详细的毒理学评价进行进一步的研究。在本文中,我们旨在提供有关印楝的传统用途、形态、植物化学、药理和毒性的所有信息,并弥补研究空白;因此,将为研究人员的进一步研究提供信息来源。
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引用次数: 0
Evaluation of anti-anxiety effects of the hydromethanolic extract of Boerhaavia diffusa L. roots in mice exposed to unpredictable chronic mild stress 白花草根氢甲醇提取物对慢性轻度应激小鼠抗焦虑作用的评价
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i2.4209
M. Kumari, Prasanti Sharma, Neelima Sharma
Stress and anxiety are common psychiatric manifestations seen because of modern-day living especially expressed during demanding situations. Boerhaavia diffusa is an important medicinal plant widely used in the northeastern part of India. This study aimed to investigate the antioxidant and anti-anxiety activities of the hydro-methanolic extract of B. diffusa roots. The antioxidant property of the hydromethanolic extract of B.diffusa was determined by in vitro antioxidant assays such as DPPH scavenging activity. The cytotoxicity of the extract was investigated using SH-SY5Y cell lines and the anxiolytic activity was evaluated using the elevated plus maze test and open field tests. The results imply that the hydromethanolic extract of B. diffusa showed excellent antioxidant activity. The extract did not show any significant toxic effect on SH-SY5Y cells. The hydro-methanolic extract of B. diffusa also demonstrated significant anxiolytic activity at 100 and 200 mg/kg doses. Thus, it can be concluded that the hydromethanolic extract of B. diffusa possesses anxiolytic activity and antioxidant properties, proving its therapeutic usefulness in the treatment of anxiety disorders.
压力和焦虑是常见的精神病学表现,因为现代生活尤其是在苛刻的情况下表现出来。白花布尔哈维亚是印度东北部广泛使用的重要药用植物。本研究旨在研究白花根水甲醇提取物的抗氧化和抗焦虑活性。通过体外抗氧化实验(如清除DPPH)测定白花莲氢甲醇提取物的抗氧化性能。采用SH-SY5Y细胞株研究其细胞毒性,采用升高+迷宫试验和野外试验评价其抗焦虑活性。结果表明,白花草氢甲醇提取物具有良好的抗氧化活性。提取物对SH-SY5Y细胞无明显毒性作用。白花草水甲醇提取物在100和200 mg/kg剂量下也表现出显著的抗焦虑活性。综上所述,白花草氢甲醇提取物具有抗焦虑和抗氧化活性,证明了白花草对焦虑症的治疗作用。
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引用次数: 0
An investigation on antioxidant and anti-arthritic activity of Rheum nobile Hook.f. & Thomson from Sikkim Himalayan region 大黄抗氧化及抗关节炎活性的研究。,汤姆森来自锡金喜马拉雅地区
Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i3.4786
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引用次数: 0
Study of drug-like characteristics of bioactive compounds identified from Dicranella pseudosubulata Müll. Hal. ex Gangulee 伪下颚地鼠属生物活性化合物类药物特性的研究。哈尔Gangulee交货
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i1.1125
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引用次数: 0
Impact of geographical location on the polyphenolic content of Nigella sativa seed extract and the relative anti-inflammatory and antioxidant potential thereof: A comparative study 地理位置对黑草籽提取物多酚含量及其抗炎、抗氧化作用的影响比较研究
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i1.1132
Singhal Rini, Verma Shweta, Singh Vijender, Bajaj Sakshi
The herb Nigella sativa belonging to the family Ranunculaceae is a well-investigated plant that has a wide range of pharmacological effects. The study aimed to evaluate and compare the antioxidant and anti-inflammatory potential as well as phytochemical screening in terms of total phenolic and flavonoid content of N. sativa seeds collected from various locations in India to establish the impact of geographical location on phytoconstituents of the seeds. The total phenolic and flavonoid content in methanolic extracts were evaluated using the Folin-ciocalteu reagent and AlCl 3 colourimetric method respectively. The antioxidant activities of the extracts were evaluated using the DPPH method, while the anti-inflammatory activity of the extracts was determined in vitro using the bovine serum albumin denaturation assay. The extract of the seed from Vizag had the highest concentration of polyphenols, followed by those from Madhya Pradesh and Punjab. The study confirmed variations in the quantity of the phytoconstituents of N. sativa seeds of different geographical origins and their consequential impact on the antioxidant and anti-inflammatory activity indicating that the geographical location exerts a vital effect on the same.
黑穗草属毛茛科,是一种被广泛研究的具有广泛药理作用的植物。本研究旨在评价和比较在印度不同地点采集的N. sativa种子的抗氧化和抗炎潜力,并根据总酚和总黄酮含量进行植物化学筛选,以确定地理位置对种子植物成分的影响。采用Folin-ciocalteu试剂和AlCl - 3比色法分别测定甲醇提取物中总酚和总黄酮的含量。采用DPPH法评价提取物的抗氧化活性,体外用牛血清白蛋白变性法测定提取物的抗炎活性。来自Vizag的种子提取物的多酚含量最高,其次是来自中央邦和旁遮普的种子提取物。本研究证实了不同产地蚕豆种子中植物成分含量的差异及其对抗氧化和抗炎活性的影响,表明地理位置对其抗氧化和抗炎活性有重要影响。
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引用次数: 0
Characterisation and identification of phenolic compounds from Asparagus laricinus and Senecio asperulus 芦笋和芦笋中酚类化合物的表征与鉴定
Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i3.5405
Nature has been a good supply of medicinal agents for thousands of years, and more than 50% of modern drugs are derived from natural sources such as plants. Asparagus laricinus and Senecio asperulus have been used in traditional remedies to treat inflammation-related disorders and cancer. This study aimed to determine the chemical composition of A. laricinus and S. asperulus crude extracts using Liquid chromatography-mass spectrometry (LC-MS/MS) based untargeted analysis. The LC-MS-based untargeted analysis showed the phytochemical profile of A. laricinus cladodes and S. asperulus roots, of which twenty-nine phytochemicals from different chemical classes were annotated, including organic acids, phenolic acids, flavonoids, and other unknown compounds. Both these plants are used as traditional medicines, and their pharmacological benefits are due to their phytochemical profile and high phenolic content.
几千年来,大自然一直是药物的良好来源,50%以上的现代药物来自植物等天然来源。芦笋和芦笋已被用于治疗炎症相关疾病和癌症的传统疗法。本研究采用液相色谱-质谱(LC-MS/MS)非靶向分析方法对松香和曲霉粗提物进行化学成分分析。基于lc - ms的非靶向分析显示了松香枝和曲霉根的植物化学图谱,其中标注了29种不同化学类的植物化学物质,包括有机酸、酚酸、黄酮类化合物和其他未知化合物。这两种植物都被用作传统药物,它们的药理益处是由于它们的植物化学特征和高酚含量。
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引用次数: 0
Investigation of antidiabetic effect of Ferula assa-foetida oleo gum resin and its essential oil on ovariectomised diabetic rats 阿魏油胶树脂及其精油对去卵巢糖尿病大鼠的降糖作用研究
Q4 Agricultural and Biological Sciences Pub Date : 2023-01-01 DOI: 10.56042/ijnpr.v14i3.4627
The aim of the present study was to evaluate the hypoglycemic activity of asafoetida and essential oil of asafoetida (EOA) in ovariectomised (OVX) diabetic rats. Twenty-four female rats were divided into four groups consisting of 6 rats in each group. OVX Control, OVX diabetic, OVX diabetic and asafoetida (25 mg/kg), OVX diabetic and EOA 25 μL/kg. Fasting Blood glucose, lipid profiles and liver indices were measured, and liver and kidney histopathology was investigated. Urine volume, urea, creatinine, and microalbumin were measured. The neuropathic damage was assessed by the hot plate method. The results showed that only in the asafoetida group the blood sugar, ALT and AST levels decreased significantly. Consumption of food, water, and body weight also decreased in the asafoetida grouponly. Also, regarding histology, relative improvement was observed in kidney and liver tissue in the asafoetida group. A significant decrease in urine volume and improvement in creatinine, urea and microalbumin concentrations, as well as improvement in hot plate test response time, were observed in both treatment groups. It can be concluded that asafoetida is effective in treating diabetes, but its essential oil has no effective activity on diabetes mellitus.
本研究的目的是评价荷叶花和荷叶花精油(EOA)对去卵巢(OVX)糖尿病大鼠的降糖活性。雌性大鼠24只,分为4组,每组6只。OVX对照、OVX糖尿病、OVX糖尿病加牛油果(25 mg/kg)、OVX糖尿病加EOA 25 μL/kg。测定空腹血糖、血脂及肝脏指标,观察肝肾组织病理学。测量尿量、尿素、肌酐和微量白蛋白。热板法评估神经病变损伤。结果显示,只有芦笋组血糖、谷丙转氨酶和谷丙转氨酶水平显著降低。食物、水和体重的消耗也仅在无尾豆科动物组有所下降。此外,在组织学方面,在肾和肝组织中观察到相对改善。在两个治疗组中,尿量显著减少,肌酐、尿素和微量白蛋白浓度显著改善,热板试验反应时间显著改善。由此可见,牛油果对糖尿病有治疗作用,但其挥发油对糖尿病无治疗作用。
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引用次数: 0
Structural Identification of Chemical Constituents Isolated from Root Extracts of Jurinea Dolomiaea Boiss (Astraceae) by Chromatographic and Spectroscopic Methods 天竺葵根提取物化学成分的色谱和光谱结构鉴定
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2022-11-10 DOI: 10.30799/jnpr.108.22080201
Bhat Mushtaq Ahmad, Ahmad Khan Fairooz, C. Harish, Saifuddin Quazi
Phytochemical screening of the extracts has shown the presence of steroids, flavonoids, saponins, glycosides, tannins, phenolic compounds, fixed oils, and fats in Jurinea dolomiaea root extracts. The presence of lupeol has been reported previously by us using high-performance thin-layer chromatography and high-performance liquid chromatography. Present research studies encompasses identification of chemical constituents in Jurinea dolomiaea roots of methanol extracts by hyphenated technique such as gas chromatography-mass spectroscopy (MS) which when coupled gives a clear insight of constituents. The components were identified by matching mass spectra with MS libraries. There were 5 different compounds analyzed from Jurinea dolomiaea roots. The identified components are (2,4-ditert-butylphenyl)-5-hydroxypentanoate, 2‑ethylhexylheptadecyl sulphite, 6-methyltridecane, (9E, 12E)-9,12-Octadecadienoyl chloride, Linoleic acid chloride, linoleoyl chloride, Lup-20 (29)-en-3-ol Lup‑20(29)‑en‑3β‑ol Lup‑20(29)‑en‑3α‑ol Lupeol, (3α)‑isomer Lupeol, (3β,18β,19β)‑isomer, in Jurinea dolomiaea root extracts.
植物化学筛选表明,白云木根提取物中存在类固醇、类黄酮、皂苷、糖苷、单宁、酚类化合物、固定油和脂肪。我们以前用高效薄层色谱法和高效液相色谱法报道过芦皮醇的存在。目前的研究包括通过气相色谱-质谱(MS)等联用技术鉴定白云木甲醇提取物根中的化学成分,当联用时可以清楚地了解成分。通过质谱与质谱库的匹配,鉴定组分。从白云木根中分析了5种不同的化合物。经鉴定的成分为(2,4-二叔丁基苯基)-5-羟基戊酸酯、2-乙基己基七烷基亚硫酸盐、6-甲基三烷、(9E, 12E)-9,12-十八烷基二烯二烯酰氯、亚油酸氯化物、亚油酰氯、Lup-20 (29)-en-3-醇Lup-20 (29)-en-3- β -醇Lup-20 (29)-en-3- α -醇Lupeol、(3α)异构体Lupeol、(3α)异构体Lupeol、(3β,18β,19β)异构体。
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引用次数: 1
Quantitative Phytochemical Screening and In-vitro Antioxidant Activities of Jatropha gossypifolia L. Leaf Extracts Aiming Antimicrobial and Therapeutical Applications 麻疯树叶提取物的体外抗氧化活性及其抗菌和治疗应用研究
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2022-05-30 DOI: 10.30799/jnpr.106.22080102
Honoré Dezoumbe Donhai, Bayoï James Ronald, Darmand Roger Djoulde, Etoa François Xavier
Total phenolic (polyphenols, flavonoids, and condensed tannins) contents and antioxidant property (DPPH, ABTS, FRAP) were evaluated in hexane (HE), acetone (AC), ethanol (ET), 70% (v/v) ethanol/water (EW), and powder extracts of Jatropha gossypifolia leaves using spectrophotometric methods. The lowest and highest contents of polyphenols (10.27 ± 0.36 and 21.23 ± 0.95 mg GAE/g), flavonoids (4.83 ±0.42 and 12.53 ±0.58 mg QE/g), and condensed tannins (3.03 ± 0.18 and 7.13 ± 0.12 mg CE/g) were recorded in powder and EW, respectively. EW exhibited the highest scavenging activities displayed by the lowest IC50 values (0.23±0.01 mg/mL DPPH and 0.2±0.03 mg/mL ABTS). Moreover, it recorded the highest reducing power (92.85±1.25 mg AAE/g), followed by HE (72.73±1.99 mg AAE/g) and AC (41.84±0.47 mg AAE/g). Relevant correlations were found between the polyphenols, flavonoids, condensed tannins and reducing antioxidant power (r = 0.986, p < 0.01; r = 0.958, p < 0.01; r =0.950, p < 0.05; respectively). Based on their phytochemical and antioxidant properties, PCA classified the five extracts into three distinct clusters. The results of this study indicate that EW contains powerful bioactive molecules with noteworthy antiradical and electron donating properties. Therefore, it may be a promising candidate in the search for natural compounds with therapeutic and food/crop preservative applications.
采用分光光度法测定了麻桐叶的己烷(HE)、丙酮(AC)、乙醇(ET)、70% (v/v)乙醇/水(EW)和粉末提取物中总酚(多酚、类黄酮和缩合单宁)含量和抗氧化性能(DPPH、ABTS、FRAP)。黄酮类化合物(4.83±0.42和12.53±0.58 mg QE/g)和缩合单宁(3.03±0.18和7.13±0.12 mg CE/g)含量最低,分别为10.27±0.36和21.23±0.95 mg GAE/g。EW的IC50值最低(DPPH为0.23±0.01 mg/mL, ABTS为0.2±0.03 mg/mL),清除活性最高。其还原力最高(92.85±1.25 mg AAE/g),其次为HE(72.73±1.99 mg AAE/g)和AC(41.84±0.47 mg AAE/g)。多酚类、黄酮类、缩合单宁与还原性抗氧化能力呈显著相关(r = 0.986, p < 0.01;R = 0.958, p < 0.01;R =0.950, p < 0.05;分别)。根据其植物化学和抗氧化特性,PCA将五种提取物分为三个不同的簇。本研究结果表明,EW含有强大的生物活性分子,具有显著的抗自由基和供电子特性。因此,在寻找具有治疗和食品/作物防腐剂应用的天然化合物方面,它可能是一个有希望的候选者。
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引用次数: 0
Effects of Solvent Extracted Bioactive Compounds from the Bark, Roots and Leaves of Croton jatrophoides on Tomato Wilt Disease (Fusarium. oxysporum f. sp. lycopersici) 麻疯豆皮、根、叶溶剂提取活性物质对番茄枯萎病的防治作用。番茄尖孢菌
IF 0.8 Q4 Agricultural and Biological Sciences Pub Date : 2022-02-23 DOI: 10.30799/jnpr.103.22080101
Kinyoda Alexander B.A.M, Mghalu Joseph Mwafaida, Guyo Paul Mwashimba, Muti Simon Mbuvi
Fusarium wilt of tomatoes, caused by Fusarium oxysporum, is a major and most prevalent soil borne disease in tomato plants both in the field and green house. The economic impact of this disease cannot be underestimated. All recommended control strategies have proved to be ineffective in controlling the pathogen. Studies have shown that Croton jatrophoides has medicinal activity against the phytopathogens. This study was conducted to evaluate the efficacy of extracts from Croton jatrophoides to suppress Fusarium oxysporum. Specific objectives were to extract bioactive compounds from C. jatrophoides for use against F. oxysporum; to determine the minimum inhibition concentration of crude extract that could elucidate response against F. oxysporum; to test in-vitro the efficacy and levels of bioactive compounds extracted using selected solvents from bark, the leaves and the root; to determine interaction effects between the treatments and the crude extracts. The experiment involved the isolation of bioactive crude extracts from the roots, bark and leaves of Croton jatrophoides plant using three solvents, namely hexane (non-polar), ethyl acetate (moderately polar) and methanol (highly polar). The isolated crude extracts from each solvent were concentrated using rotary evaporator, then purified using micro-filters. These extracts were then used for testing their antifungal activity in Potatoes Dextrose Agar (PDA) petri-plates containing Fusarium oxysporum inoculum. The results indicated that the quantity of the solvent required for exhaustive extraction of bioactive compounds from the ground material was at 180 mL. The minimum inhibition concentration that elucidated response against F. oxysporum was found to be 50.0 mg/mL. Non-polar solvents such as hexane and ethyl acetate were found to have the highest abilities in extracting bioactive compounds from C. jatropoides materials since most of these compounds that had antifungal activity were non-polar. Hexane derived extracts had the highest significant efficacy in control of Fusarioum oxysporum, comparable to Rindomil, a positive control. Dimethyl sulfoxide (DMSO) had the least effect on Fusarioum oxysporum. In the absence of hexane, ethyl acetate was the second most suited solvent for extraction of bioactive compounds from C. jatrophoides. Methanol had the least abilities in extraction of bioactive compounds from C. jatrophoides. There were interaction effects between the parts of the plants from which bioactive compounds were derived and the type of solvents used.
番茄枯萎病(Fusarium wilt)是由尖孢镰刀菌(Fusarium oxysporum)引起的番茄土传病害,是番茄田间和温室最常见的土传病害。这种疾病的经济影响不容低估。所有推荐的控制策略在控制病原菌方面都被证明是无效的。研究表明,麻疯豆具有抗植物病原菌的药用活性。研究了麻疯豆提取物对尖孢镰刀菌的抑菌效果。目的:从麻疯树中提取抗尖孢镰刀菌的活性物质;确定粗提物对尖孢镰刀菌的最低抑菌浓度;在体外测试使用选定的溶剂从树皮、叶子和根中提取的生物活性化合物的功效和水平;测定各处理与粗提物的交互作用。本实验采用正己烷(非极性)、乙酸乙酯(中极性)和甲醇(高极性)三种溶剂分离麻疯巴豆根、树皮和叶片的生物活性粗提物。从每种溶剂中分离得到的粗提物用旋转蒸发器浓缩,然后用微过滤器纯化。然后用这些提取物在含尖孢镰刀菌接种的马铃薯葡萄糖琼脂(PDA)培养皿中检测其抗真菌活性。结果表明,从地底物质中提取活性物质所需的溶剂量为180 mL,对尖孢镰刀菌有抑制作用的最低浓度为50.0 mg/mL。正己烷和乙酸乙酯等非极性溶剂对麻风麻属植物活性物质的提取能力最高,因为这些具有抗真菌活性的物质大多是非极性的。己烷提取物对尖孢镰刀菌的防治效果最高,与阳性对照林多密相当。二甲亚砜(DMSO)对尖孢镰刀菌的抑制作用最小。在不含己烷的情况下,乙酸乙酯是第二适合提取麻疯树生物活性物质的溶剂。甲醇对麻疯树中活性物质的提取能力最差。提取生物活性化合物的植物部位与使用的溶剂类型之间存在相互作用。
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引用次数: 1
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Indian Journal of Natural Products and Resources
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