Seema Guragain, Sandip Kumar Mandal, Suman Gnawali, S. Panday, Nitu Sharma, G. D. Adhikari, Ajay Kumar Yadav
Introduction: Ultrasonography (USG) is one of the modality of choice for detection of breast lesions due to its advantage over radiation exposure, differentiation between solid tumor and cyst filled with fluid, especially for imaging of young age females. The aim of the study is to find out the prevalence of breast cancer among the patients undergoing scanning of USG and estimate its sensitivity, specificity and accuracy to detect breast lesion in comparison with histopathology. Materials and Methods: A descriptive cross-sectional study was conducted from 15th April to 10th September, 2022. A sample size of 426 was taken in convenience sampling method. Collected data were entered and analyzed on SPSS 25.0. Sensitivity, specificity and accuracy of USG to detect breast lesion in comparison to histopathology findings. Results: Among 426 patients sample coming from OPD, breast cancer was seen in 53 (12.44%) patients. Among 426, 418 were female and 8 were male patients. Age ranged from 13-75 years. The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of USG to detect breast lesion are 94%, 100%, 94.23%, 100% and 97% respectively. Conclusion: The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of USG to detect breast lesion is quite high. USG is highly recommended in examination of breast lesions.
{"title":"Breast carcinoma among patients undergoing breast ultrasonography in a tertiary care center: A descriptive cross-sectional study","authors":"Seema Guragain, Sandip Kumar Mandal, Suman Gnawali, S. Panday, Nitu Sharma, G. D. Adhikari, Ajay Kumar Yadav","doi":"10.3126/njc.v7i1.60028","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60028","url":null,"abstract":"Introduction: Ultrasonography (USG) is one of the modality of choice for detection of breast lesions due to its advantage over radiation exposure, differentiation between solid tumor and cyst filled with fluid, especially for imaging of young age females. The aim of the study is to find out the prevalence of breast cancer among the patients undergoing scanning of USG and estimate its sensitivity, specificity and accuracy to detect breast lesion in comparison with histopathology. Materials and Methods: A descriptive cross-sectional study was conducted from 15th April to 10th September, 2022. A sample size of 426 was taken in convenience sampling method. Collected data were entered and analyzed on SPSS 25.0. Sensitivity, specificity and accuracy of USG to detect breast lesion in comparison to histopathology findings. Results: Among 426 patients sample coming from OPD, breast cancer was seen in 53 (12.44%) patients. Among 426, 418 were female and 8 were male patients. Age ranged from 13-75 years. The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of USG to detect breast lesion are 94%, 100%, 94.23%, 100% and 97% respectively. Conclusion: The sensitivity, specificity, negative predictive value, positive predictive value and accuracy of USG to detect breast lesion is quite high. USG is highly recommended in examination of breast lesions.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139220733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manju Pandey, Bijay Chandra Acharya, H. Subedi, S. Gurung, Bibek Kandel, G. D. Adhikari, Binuma Shrestha
Correspondence Dr Manju Pandey , Gynecology Oncology Unit, Dept. of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal. Email: drmanju921@gmail.com Introduction: Ovarian cancer is the most lethal gynecological malignancy diagnosed at late stage in most of the cases. Management includes primary debulking surgery with a target of no gross residual disease or ≤ 1cm residual disease followed by paclitaxel and carboplatin-based chemotherapy. Neoadjuvant chemotherapy of at least 3 cycles followed by interval debulking surgery is an alternative option in selected cases of advanced disease. Material and Method: A prospective study was carried out at B.P. Koirala Memorial Cancer Hospital, Bharatpur, Chitwan from the period 1st November 2022 to 31st August 2023 (10 months). Patients diagnosed with advanced ovarian cancer based on clinical and CECT findings and confirmed with cytology or FNAC or biopsy undergoing Interval Debulking Surgery after 3 cycles of NACT (paclitaxel and carboplatin) were included. The role of NACT in terms of response according to RECIST criteria, regression of CA125 value, rate of complete or optimal cytoreduction, and postoperative complications were analyzed. Results: A total of 40 cases fulfilling the inclusion criteria were enrolled. Most patients 14(35%) were between 51-60 years with a mean age of 51.45 ± 11.46 SD years. Abdominal pain and/or distension were the most common presenting symptoms. The majority 32 (84.2%) of cases were given NACT based on CT scan findings of advanced disease. Confirmation of malignancy was done by positive USG-guided FNAC from ovarian mass in most cases 23 (57.5%), followed by positive ascitic fluid cytology in 8 (20%) patients. The median CA125 value before and after NACT were 844 U/ml and 27.89 U/ml respectively. After NACT, CA125 was normalized in 24 (60%) patients. Most patients 30 (75%) had complete cytoreduction during IDS; while 7 (17.5%) patients had optimal cytoreduction, and 3 (7.5%) had suboptimal cytoreduction. The median duration of surgery was 147.5 minutes, and the median blood loss was 287.5 ml. The postoperative period was uneventful in most cases. Conclusions: NACT followed by interval debulking surgery is an effective alternative in selected cases of advanced ovarian cancer as the complete and optimal cytoreduction rate is higher with fewer postoperative complications.
{"title":"Role of Neoadjuvant Chemotherapy on Advanced Epithelial Ovarian Cancer","authors":"Manju Pandey, Bijay Chandra Acharya, H. Subedi, S. Gurung, Bibek Kandel, G. D. Adhikari, Binuma Shrestha","doi":"10.3126/njc.v7i1.60282","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60282","url":null,"abstract":"Correspondence Dr Manju Pandey , Gynecology Oncology Unit, Dept. of Surgical Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal. Email: drmanju921@gmail.com Introduction: Ovarian cancer is the most lethal gynecological malignancy diagnosed at late stage in most of the cases. Management includes primary debulking surgery with a target of no gross residual disease or ≤ 1cm residual disease followed by paclitaxel and carboplatin-based chemotherapy. Neoadjuvant chemotherapy of at least 3 cycles followed by interval debulking surgery is an alternative option in selected cases of advanced disease. Material and Method: A prospective study was carried out at B.P. Koirala Memorial Cancer Hospital, Bharatpur, Chitwan from the period 1st November 2022 to 31st August 2023 (10 months). Patients diagnosed with advanced ovarian cancer based on clinical and CECT findings and confirmed with cytology or FNAC or biopsy undergoing Interval Debulking Surgery after 3 cycles of NACT (paclitaxel and carboplatin) were included. The role of NACT in terms of response according to RECIST criteria, regression of CA125 value, rate of complete or optimal cytoreduction, and postoperative complications were analyzed. Results: A total of 40 cases fulfilling the inclusion criteria were enrolled. Most patients 14(35%) were between 51-60 years with a mean age of 51.45 ± 11.46 SD years. Abdominal pain and/or distension were the most common presenting symptoms. The majority 32 (84.2%) of cases were given NACT based on CT scan findings of advanced disease. Confirmation of malignancy was done by positive USG-guided FNAC from ovarian mass in most cases 23 (57.5%), followed by positive ascitic fluid cytology in 8 (20%) patients. The median CA125 value before and after NACT were 844 U/ml and 27.89 U/ml respectively. After NACT, CA125 was normalized in 24 (60%) patients. Most patients 30 (75%) had complete cytoreduction during IDS; while 7 (17.5%) patients had optimal cytoreduction, and 3 (7.5%) had suboptimal cytoreduction. The median duration of surgery was 147.5 minutes, and the median blood loss was 287.5 ml. The postoperative period was uneventful in most cases. Conclusions: NACT followed by interval debulking surgery is an effective alternative in selected cases of advanced ovarian cancer as the complete and optimal cytoreduction rate is higher with fewer postoperative complications.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139225964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Esophageal anastomotic leakage (AL) remains a frequent and feared postoperative complication, associated with high mortality and impaired quality of life. The aim of this study was to assess AL rates after esophagectomy with anastomosis at neck for esophageal and gastroesophageal junction cancer (GEJ), and compare the impact of AL on oncological outcome. Methods: Patients with squamous cell carcinoma and adenocarcinoma of esophagus/ gastroesophageal junction who underwent surgery between 2001-2018 were analyzed for cervical anastomotic leak. Results: 419 patients underwent esophagectomy with anastomosis placed at neck during 2001-2018. AL rate was 16%. AL was not found to be associated with anastomotic technique, surgical approach and technique, organ of conduit and route of conduit. A subgroup of patients (n=93) who had undergone neoadjuvant chemoradiation followed by surgery had AL of 30% vs 12% in rest of the treatment modality group (p<0.001). Median survival was 26 months and 34 months in patients with AL and without AL, respectively (p=0.03). AL was managed successfully in all patients. Conclusion: Cervical AL after esophagectomy for cancer of esophagus and GEJ can be treated successfully without major complications.
背景：食管吻合口漏（AL）仍是一种常见且令人担忧的术后并发症，与高死亡率和生活质量下降有关。本研究旨在评估食管癌和胃食管交界处癌（GEJ）颈部吻合食管切除术后的 AL 发生率，并比较 AL 对肿瘤预后的影响。方法分析2001-2018年间接受手术的食管/胃食管交界处鳞状细胞癌和腺癌患者的颈部吻合口漏情况。结果2001-2018年间，419名患者接受了食管切除术，并在颈部放置了吻合器。AL率为16%。未发现 AL 与吻合技术、手术方法和技术、导管器官和导管路径有关。接受新辅助化疗后再手术的亚组患者（93人）的AL率为30%，而其他治疗方式组的AL率为12%（P<0.001）。有AL和无AL患者的中位生存期分别为26个月和34个月（P=0.03）。所有患者均成功控制了 AL。结论食管癌和胃食管癌食管切除术后的宫颈 AL 可成功治愈，且无重大并发症。
{"title":"Anastomotic leak after esophagectomy","authors":"Binay Thakur, Ming Yang, Nikesh Bhandari, Zhenpin Sun, Shashank Shrestha, Ashish Kharel, Deewash Neupane, Asha Thapa","doi":"10.3126/njc.v7i1.59993","DOIUrl":"https://doi.org/10.3126/njc.v7i1.59993","url":null,"abstract":"Background: Esophageal anastomotic leakage (AL) remains a frequent and feared postoperative complication, associated with high mortality and impaired quality of life. The aim of this study was to assess AL rates after esophagectomy with anastomosis at neck for esophageal and gastroesophageal junction cancer (GEJ), and compare the impact of AL on oncological outcome. Methods: Patients with squamous cell carcinoma and adenocarcinoma of esophagus/ gastroesophageal junction who underwent surgery between 2001-2018 were analyzed for cervical anastomotic leak. Results: 419 patients underwent esophagectomy with anastomosis placed at neck during 2001-2018. AL rate was 16%. AL was not found to be associated with anastomotic technique, surgical approach and technique, organ of conduit and route of conduit. A subgroup of patients (n=93) who had undergone neoadjuvant chemoradiation followed by surgery had AL of 30% vs 12% in rest of the treatment modality group (p<0.001). Median survival was 26 months and 34 months in patients with AL and without AL, respectively (p=0.03). AL was managed successfully in all patients. Conclusion: Cervical AL after esophagectomy for cancer of esophagus and GEJ can be treated successfully without major complications.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"4 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139222622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anatomic variations of hepatic arteries are observed in 12-49% cases. But replaced right and left hepatic arteries are extremely rare (0.8%). We report a 61 years old male patient with the diagnosis of gastric cancer. He underwent distal subtotal gastrectomy with D2 lymphadenectomy. Intraoperatively, both right and left hepatic arteries were replaced and were arising from superior mesenteric artery and aorta, respectively.
{"title":"Aberrent hepatic arteries, a rare anatomic variant: case report","authors":"Rajendra Dhakal, Binay Thakir, Shashank Shrestha, Ashish Kharel, Pankaj Shah, Bibhay Hari Koirala, Shiva Kandel, Deewash Neupane","doi":"10.3126/njc.v7i1.59995","DOIUrl":"https://doi.org/10.3126/njc.v7i1.59995","url":null,"abstract":"Anatomic variations of hepatic arteries are observed in 12-49% cases. But replaced right and left hepatic arteries are extremely rare (0.8%). We report a 61 years old male patient with the diagnosis of gastric cancer. He underwent distal subtotal gastrectomy with D2 lymphadenectomy. Intraoperatively, both right and left hepatic arteries were replaced and were arising from superior mesenteric artery and aorta, respectively.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139222762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Thoracoscopy is a useful procedure for evaluation and diagnosis of pleural effusion and other thoracic disorders. Our study aimed to evaluate the scope and use of thoracoscopic biopsy for the evaluation of thoracic disorders and report on the outcomes of this technique. Methods: Patients undergoing thoracoscopic biopsy procedure from March 2022 to May 2023 were analyzed for indications, complication and outcomes. Results: 85 patients underwent thoracoscopic biopsy over a period of 15 months, of which 38 (44.7%) were males and 47 (55.3%) were females. The mean age was 60 years. Cough, dyspnea and chest pain were the most common presenting symptoms. Thoracosopy was most commonly done on the right side (67.1%). Pleura (57.6%) was the most common biopsy site, followed by lungs (22.4%), lymph node (12.9%) and mediastinum (3.7%). One case was converted to open procedure. Post operative complication rate was 3.5%. Adenocarcinoma (31.8%) was the most common histology, followed by squamous cell carcinoma (9.4%). 36.5% patients had benign disease and 11.8% patients had metastatic extra-thoracic malignancy. Conclusion: Thoracoscopy is a safe and simple procedure for diagnosis of pleural and other thoracic disorders with the advantage of tissue sampling from lesion under direct visualization. It is a useful tool in the armamentarium of thoracic surgeons.
{"title":"Thoracoscopic biopsy in the diagnosis of lung and pleural diseases","authors":"Ashish Kharel, Binay Thakur, Ming Yang, Nikesh Bhandari, Zhenqing Sun, Shashank Shrestha, Bhuwan Ghimire, Deewash Neupane","doi":"10.3126/njc.v7i1.60023","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60023","url":null,"abstract":"Background: Thoracoscopy is a useful procedure for evaluation and diagnosis of pleural effusion and other thoracic disorders. Our study aimed to evaluate the scope and use of thoracoscopic biopsy for the evaluation of thoracic disorders and report on the outcomes of this technique. Methods: Patients undergoing thoracoscopic biopsy procedure from March 2022 to May 2023 were analyzed for indications, complication and outcomes. Results: 85 patients underwent thoracoscopic biopsy over a period of 15 months, of which 38 (44.7%) were males and 47 (55.3%) were females. The mean age was 60 years. Cough, dyspnea and chest pain were the most common presenting symptoms. Thoracosopy was most commonly done on the right side (67.1%). Pleura (57.6%) was the most common biopsy site, followed by lungs (22.4%), lymph node (12.9%) and mediastinum (3.7%). One case was converted to open procedure. Post operative complication rate was 3.5%. Adenocarcinoma (31.8%) was the most common histology, followed by squamous cell carcinoma (9.4%). 36.5% patients had benign disease and 11.8% patients had metastatic extra-thoracic malignancy. Conclusion: Thoracoscopy is a safe and simple procedure for diagnosis of pleural and other thoracic disorders with the advantage of tissue sampling from lesion under direct visualization. It is a useful tool in the armamentarium of thoracic surgeons.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139223309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Palliative care (PC) is considered an integral component of comprehensive cancer care. Insufficient knowledge among nurses was one of the main obstacles to providing high-quality palliative care services. This study assessed oncology nurses' knowledge and attitude toward palliative care. Method: A cross-sectional study was conducted among 125 oncology nurses working at B.P. Koirala Memorial Cancer Hospital (BPKMCH). A simple random sampling technique was used. The self-administered questionnaire: Palliative Care Quiz for Nursing (PCQN) and “From melt Attitudes toward Care of the Dying Scale (FATCOD) were used to assess knowledge and attitude. The data were analyzed and interpreted using SPSS version 22. The p-value was set at <0.05. Results: The majority (59.2) of nurses had a poor level of knowledge with a mean PCQN score for was (9.208 ±2.052) out of 20. The lowest score in the psychological/spiritual subcategory. The majority (89.6%) of nurses had good attitudes, with a mean attitude score was (109.816 ± 9.788). There was a significant association found between the level of knowledge with educational status (P = 0.041), current working area (P = 0.017), and working experience (P = 0.008). Likewise, a significant association was also found between the level of attitude and current working area (P = 0.018). Conclusion: The majority of the nurses working at BPKMCH had poor levels of knowledge, whereas, most nurses had good attitudes toward PC. A significant association was found between the level of knowledge with educational status, current working area, and work experience.
简介 姑息关怀（PC）被认为是癌症综合治疗不可或缺的组成部分。护士知识不足是提供高质量姑息关怀服务的主要障碍之一。本研究评估了肿瘤科护士对姑息治疗的认识和态度。方法：横断面研究 对 125 名在柯伊拉腊纪念癌症医院（B.P. Koirala Memorial Cancer Hospital，BPKMCH）工作的肿瘤科护士进行了横断面研究。研究采用了简单随机抽样技术。自制问卷自编问卷：护理姑息关怀测验（PCQN）和 "临终关怀态度量表（FATCOD）"用于评估知识和态度。数据使用 SPSS 22 版本进行分析和解释。P值设定为<0.05。 结果大多数护士（59.2%）的知识水平较差，PCQN 平均分为（9.208 ± 2.052）（满分 20 分）。 心理/精神子类别得分最低。大多数护士（89.6%）的态度良好，平均态度得分为（109.816 ± 9.788）。知识水平与受教育程度（P = 0.041）、当前工作地区（P = 0.017）和工作经验（P = 0.008）之间存在明显关联。同样，态度水平与当前工作地区（P = 0.018）之间也存在明显关联。 结论大多数在北京朝阳医院工作的护士对 PC 的认知水平较低，而大多数护士对 PC 的态度良好。研究发现，知识水平与教育程度、目前工作地区和工作经验之间存在明显关联。
{"title":"Oncology Nurses’ Knowledge and Attitude towards Palliative Care","authors":"Usha Thapa, Sabita Panthi, Laxmi Neupane","doi":"10.3126/njc.v7i1.60025","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60025","url":null,"abstract":"Introduction: Palliative care (PC) is considered an integral component of comprehensive cancer care. Insufficient knowledge among nurses was one of the main obstacles to providing high-quality palliative care services. This study assessed oncology nurses' knowledge and attitude toward palliative care. Method: A cross-sectional study was conducted among 125 oncology nurses working at B.P. Koirala Memorial Cancer Hospital (BPKMCH). A simple random sampling technique was used. The self-administered questionnaire: Palliative Care Quiz for Nursing (PCQN) and “From melt Attitudes toward Care of the Dying Scale (FATCOD) were used to assess knowledge and attitude. The data were analyzed and interpreted using SPSS version 22. The p-value was set at <0.05. Results: The majority (59.2) of nurses had a poor level of knowledge with a mean PCQN score for was (9.208 ±2.052) out of 20. The lowest score in the psychological/spiritual subcategory. The majority (89.6%) of nurses had good attitudes, with a mean attitude score was (109.816 ± 9.788). There was a significant association found between the level of knowledge with educational status (P = 0.041), current working area (P = 0.017), and working experience (P = 0.008). Likewise, a significant association was also found between the level of attitude and current working area (P = 0.018). Conclusion: The majority of the nurses working at BPKMCH had poor levels of knowledge, whereas, most nurses had good attitudes toward PC. A significant association was found between the level of knowledge with educational status, current working area, and work experience.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139223410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manisha K C, K. Amatya, Alissa K C, Pratik Bhattarai, Sreya Shah, Nabin Rana
Leiomyosarcoma is an uncommon form of breast cancer, accounting for 5-10% of all breast sarcomas with only 704 instances recorded to date. Waterwarth described the first instance of primary leiomyosarcoma breast (PLB) in 1968. This is the first case of PLB documented in Nepal, that we’re aware of. Leiomyosarcoma is a malignant non-epithelial smooth muscle tumor that can occur anywhere in the body. We discuss the case of a 41-year-old female who presented with a breast lump that was subsequently confirmed as Primary leiomyosarcoma and was treated with wide local excision with margins. We've been watching her progress for a year.
{"title":"Primary Leiomyosarcoma of Breast: A case report from Nepal","authors":"Manisha K C, K. Amatya, Alissa K C, Pratik Bhattarai, Sreya Shah, Nabin Rana","doi":"10.3126/njc.v7i1.60024","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60024","url":null,"abstract":"Leiomyosarcoma is an uncommon form of breast cancer, accounting for 5-10% of all breast sarcomas with only 704 instances recorded to date. Waterwarth described the first instance of primary leiomyosarcoma breast (PLB) in 1968. This is the first case of PLB documented in Nepal, that we’re aware of. Leiomyosarcoma is a malignant non-epithelial smooth muscle tumor that can occur anywhere in the body. We discuss the case of a 41-year-old female who presented with a breast lump that was subsequently confirmed as Primary leiomyosarcoma and was treated with wide local excision with margins. We've been watching her progress for a year.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139218073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Pediatric tumor is often an incidental discovery. Improvements in diagnosis modality and treatment have decreased the mortality rates. Materials and Method: We performed a retrospective review of pediatric patients operated in the Department of Urology at B.P. Koirala Memorial Cancer Hospital from January 2018 to December 2022. Results: A total of 28 pediatric patients were operated for cancers in that time duration. Among them there were 6 cases of Neuroblastoma, 19 cases of Nephroblastoma and 3 cases of Testicular germ cell tumors. Conclusion: Despite limited resources, a fair number of pediatric tumors are being managed in BPKMCH with good results.
{"title":"Pediatric urological malignancies operated at a tertiary cancer center in Nepal: a 5 year experience","authors":"Sulav Pradhan, U. Nepal, Bharat Mani Pokharel, Binod Babu Gharti, Gyan Prasad Pokharel, Nirmal Lamichhane","doi":"10.3126/njc.v7i1.60026","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60026","url":null,"abstract":"Introduction: Pediatric tumor is often an incidental discovery. Improvements in diagnosis modality and treatment have decreased the mortality rates. Materials and Method: We performed a retrospective review of pediatric patients operated in the Department of Urology at B.P. Koirala Memorial Cancer Hospital from January 2018 to December 2022. Results: A total of 28 pediatric patients were operated for cancers in that time duration. Among them there were 6 cases of Neuroblastoma, 19 cases of Nephroblastoma and 3 cases of Testicular germ cell tumors. Conclusion: Despite limited resources, a fair number of pediatric tumors are being managed in BPKMCH with good results.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139227384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Baniya, Binuma Shrestha, Bijay Chandra Acharya, S. Gurung, H. Subedi, Manju Pandey, Shristi Tiwari, Pramila Thapa
Background: Ovarian cancer; 5th commonest cancer among Nepalese women is the leading cause of gynecologic cancer related death. Proper diagnostic studies therefore assist Gyne-oncologist for appropriate surgery and chemotherapeutic planning, there by optimizing the patient prognosis. Objective of current study was to compare ultrasonography imaging, CT imaging, CA 125 value, RMI 4 score and surgical staging in diagnosis of ovarian cancer correlated with histo-pathological findings. Materials and Methods: The study was retrospective observational study, carried out between 14th April 2019 to 16th October 2021, in the department of surgical oncology (Gynecology oncology unit), B.P Koirala Memorial Cancer Hospital, Bharatpur. Results: 53 patient data were included in the observation. The efficacy of Ultrasound (sensitivity-90.90%, Specificity-60%) and CT (sensitivity-100%, specificity-65%) gave the best result in non-invasive investigations; whereas surgical staging (sensitivity- 96.96%, specificity- 90%) gave the better result when invasive modalities were considered. RMI 4 score had sensitivity 96.96% and specificity 60%. Conclusion: All modalities had good diagnostic performances and complemented each other in further defining the characterization of the ovarian mass, local spread and distant tumor dissemination.
{"title":"Study of Comparison of conventional ultrasound, RMI 4 score and CT imaging in diagnosis of Ovarian Cancer confirmed by surgical-pathological findings","authors":"S. Baniya, Binuma Shrestha, Bijay Chandra Acharya, S. Gurung, H. Subedi, Manju Pandey, Shristi Tiwari, Pramila Thapa","doi":"10.3126/njc.v7i1.60157","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60157","url":null,"abstract":"Background: Ovarian cancer; 5th commonest cancer among Nepalese women is the leading cause of gynecologic cancer related death. Proper diagnostic studies therefore assist Gyne-oncologist for appropriate surgery and chemotherapeutic planning, there by optimizing the patient prognosis. Objective of current study was to compare ultrasonography imaging, CT imaging, CA 125 value, RMI 4 score and surgical staging in diagnosis of ovarian cancer correlated with histo-pathological findings. Materials and Methods: The study was retrospective observational study, carried out between 14th April 2019 to 16th October 2021, in the department of surgical oncology (Gynecology oncology unit), B.P Koirala Memorial Cancer Hospital, Bharatpur. Results: 53 patient data were included in the observation. The efficacy of Ultrasound (sensitivity-90.90%, Specificity-60%) and CT (sensitivity-100%, specificity-65%) gave the best result in non-invasive investigations; whereas surgical staging (sensitivity- 96.96%, specificity- 90%) gave the better result when invasive modalities were considered. RMI 4 score had sensitivity 96.96% and specificity 60%. Conclusion: All modalities had good diagnostic performances and complemented each other in further defining the characterization of the ovarian mass, local spread and distant tumor dissemination.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Epithelial ovarian cancer (EOC) represents about two-thirds of ovarian malignancies and usually presents with advanced disease. Primary cytoreductive (PCR) surgery is known to be the cornerstone of treatment of advanced EOC, but it might not always be feasible to obtain optimal cytoreduction. Neoadjuvant chemotherapy (NACT) has been proposed as an alternative approach. This study aims to compare the survival of patients, post-operative morbidity and the extent of cytoreduction that was achieved among the two treatment groups. Methods: A retrospective cohort study was done in Bhaktapur Cancer Hospital of Nepal. All women who underwent surgical management for advanced epithelial ovarian cancer from 2016 to 2019 were included in the study and analyzed using SPSS version 23. Results: Among 29 cases of advanced EOC, seven cases underwent PCR and 22 cases had NACT followed by interval cytoreduction (ICR). Optimal debulking was achieved in 85.7% of the cases in the PCR group and in 95.5% in the NACT+ICR group. Overall survival of >3 years in the PCR group was 42.9% while in the NACT group was 59.1%. Progression free survival (PFS) of >3 years was seen in 28.6% in the PCR group and in 45.5% in the NACT group. Conclusions: The current study shows that NACT followed by ICR has better survival outcomes than PCR. Despite the limitations of the study, NACT + ICR can be considered a reasonable alternative to PCR in advanced EOC.
{"title":"Primary Cytoreductive Surgery versus Neoadjuvant Chemotherapy followed by Interval Cytoreductive Surgery for Advanced Epithelial Ovarian Cancer: A Retrospective Cohort Study","authors":"Shristee Shrestha Prajapati, Anisha Shrestha, Usha Shrestha, Roshan Prajapati, Sagar Tiwari, Siddinath Gyawali, G. Sah","doi":"10.3126/njc.v7i1.60019","DOIUrl":"https://doi.org/10.3126/njc.v7i1.60019","url":null,"abstract":"Introduction: Epithelial ovarian cancer (EOC) represents about two-thirds of ovarian malignancies and usually presents with advanced disease. Primary cytoreductive (PCR) surgery is known to be the cornerstone of treatment of advanced EOC, but it might not always be feasible to obtain optimal cytoreduction. Neoadjuvant chemotherapy (NACT) has been proposed as an alternative approach. This study aims to compare the survival of patients, post-operative morbidity and the extent of cytoreduction that was achieved among the two treatment groups. Methods: A retrospective cohort study was done in Bhaktapur Cancer Hospital of Nepal. All women who underwent surgical management for advanced epithelial ovarian cancer from 2016 to 2019 were included in the study and analyzed using SPSS version 23. Results: Among 29 cases of advanced EOC, seven cases underwent PCR and 22 cases had NACT followed by interval cytoreduction (ICR). Optimal debulking was achieved in 85.7% of the cases in the PCR group and in 95.5% in the NACT+ICR group. Overall survival of >3 years in the PCR group was 42.9% while in the NACT group was 59.1%. Progression free survival (PFS) of >3 years was seen in 28.6% in the PCR group and in 45.5% in the NACT group. Conclusions: The current study shows that NACT followed by ICR has better survival outcomes than PCR. Despite the limitations of the study, NACT + ICR can be considered a reasonable alternative to PCR in advanced EOC.","PeriodicalId":133249,"journal":{"name":"Nepalese Journal of Cancer","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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