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Nasal NK/T-cell lymphoma: Clinical features and dermoscopic appearances 鼻NK/ t细胞淋巴瘤:临床特征和皮肤镜表现
Pub Date : 2020-01-01 DOI: 10.37532/1755-5191.2020.12(1).4
J. Ziani, M. Bennani, Z. Douhi, S. Elloudi, Hanane Baybay Fatima Zahra Mernissi
CA 18y old female without family history, who presented 6 months before, a right nasal swelling with the notion of right nasal obstruction evolving towards an ulcerated tumor whose biopsy returned in favor of a nasal NK lymphoma. Physical examination showed a right nasal destructive ulcerated tumor, with an infiltrated base, with a necrotic surface with a purulent background and with clear and irregular boundaries making 6cm of the long axis (FIGURE 1). In dermoscopy appearance we had especially an aspect in gaps with separations by whitish septa (FIGURE 2).
CA 18岁女性,无家族史,6个月前出现右鼻肿胀,伴有右鼻塞的概念,逐渐发展为溃疡性肿瘤,活检结果显示为鼻NK淋巴瘤。体格检查显示右侧鼻腔破坏性溃疡性肿瘤,基底浸润,坏死表面化脓性背景,边界清晰不规则,长轴长6cm(图1)。在皮肤镜检查中,我们特别发现间隙有白色间隔分隔(图2)。
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引用次数: 0
Cardiac Metastasis In A Patient With Poorly-differentiated Neuroendorcrine Tumor: 18F-FDG PET-CT Finding 低分化神经内分泌肿瘤患者的心脏转移:18F-FDG PET-CT发现
Pub Date : 2019-01-01 DOI: 10.14303/imaging-medicine.1000127
Salah Nabih Oueriaglia, A. Doudouh, N. Loudiyi, M. Raissouni
1 ISSN 1755-5191 We describe 18F-FDG positon emission tomography-computed tomography findings of a 67 y old male patient, followed since 2014 for poorly differentiated NETs with unknown primary tumor. PET-CT showed cardiac hypermetabolism in the left ventricular as muscular metastasis in addition to other muscular metastases of the two diaphragmatic pillars and the left iliopsoas muscle (FIGURE 1). Cardiac USN and chest-CT (FIGURES 2 & 3) confirmed our diagnostic by showing a small lesion in the cardiac apex measuring 13.7 × 18 mm. Myocardial metastases are very rare with a reported incidence up to 1 to 4% [1]. 18F-FDG is a positron emission tomography tracer for poorly differentiated NETs with KI67>20% [2]. This modality of exploration is useful for the staging and the restaging patients. The maximum detection was correlated to a low somatostatin receptor (SSRT) expression unlike well-differentiated tumors that show great expression of these receptors [3]. Cardiac metastasis in a patient with poorly-differentiated neuroendorcrine tumor: 18F-FDG PET-CT finding
我们描述了一名67岁男性患者的18F-FDG位置发射断层扫描-计算机断层扫描结果,自2014年以来一直随访低分化NETs伴未知原发肿瘤。PET-CT显示左心室的心脏高代谢为肌肉转移,此外还有两横膈柱和左髂腰肌的其他肌肉转移(图1)。心脏USN和胸部ct(图2和3)显示心脏顶端有一个13.7 × 18 mm的小病变,证实了我们的诊断。心肌转移非常罕见,据报道发生率为1% ~ 4%[1]。18F-FDG是一种正电子发射断层扫描示踪剂,用于KI67>20%的低分化NETs[2]。这种探查方式对患者的分期和再分期是有用的。最大检出与生长抑素受体(SSRT)低表达相关,而分化良好的肿瘤则表现出这些受体的高表达[3]。低分化神经内分泌肿瘤患者的心脏转移:18F-FDG PET-CT发现
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引用次数: 0
Genital Self-mutilation In Schizophreni 精神分裂症患者生殖器自残
Pub Date : 2019-01-01 DOI: 10.14303/IMAGING-MEDICINE.1000131
O. AmraniSouhli, M. Ahsaini, J. Omana, N. Alaoui, S. Mellas, J. Ammari, Tazi Mf Farih Mh
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引用次数: 0
Carcinoma of tongue in xeroderma pigmentosum a medical image 色素性干皮病的舌癌
Pub Date : 2019-01-01 DOI: 10.14303/IMAGING-MEDICINE.1000128
S. Kajal, A. Agrawal
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引用次数: 3
Saffron Extract Prevents Vancomycin-induced Nephrotoxicity 藏红花提取物防止万古霉素引起的肾毒性
Pub Date : 2019-01-01 DOI: 10.14303/Imaging-Medicine.1000129
M. Jenabi, A. Hemmati, K. Hafezi, Esrafil Mansouri
Background: Vancomycin, a glycopeptide antibiotic, is commonly used against methicillin-resistant Gram-positive cocci. However, the nephrotoxic side-effects of Vancomycin results in dose restriction and reduces the duration of administration. Objectives: The present study was designed to evaluate the protective effects of aqueous saffron (Crocus sativus) extract on vancomycin-induced nephrotoxicity in rats. Materials and methods: In this study 32 adult male Wistar rats were randomly divided into 4 groups of 8 rats; (i) control (ii) saffron (80 mg/kg, I.P.), (iii) vancomycin (200 mg/kg/BD, I.P.) and (iv) vancomycin plus saffron. The saffron treatment began 24 hours before the administration of the vancomycin therapy and lasted 8 days, while the duration of the vancomycin therapy was 7 days. Serum creatinine and blood urea nitrogen (BUN), renal malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity and histopathological changes of renal tissue were analyzed. Results: Administration of vancomycin caused a significant increase in serum creatinine, BUN and renal MDA levels, whereas, SOD activity was decreased, when compared to the control group. Aqueous saffron extract, on the other hand, decreased serum creatinine, BUN concentration and renal MDA levels but increased the level of renal SOD activity. Substantial histopathological alterations including destruction of kidney tubules, interstitial edema, epithelia vacuolization and epithelial desquamation, were observed with the vancomycin-only treatment group. However, the administration of saffron extract resulted in a significant reduction of damage to the kidneys. Conclusion: The present study demonstrated that oxidative stress plays an important role in vancomycin induced nephrotoxicity and saffron extract has a potent renoprotective effect against vancomycin induced lipid peroxidation and nephrotoxicity.
背景:万古霉素是一种糖肽类抗生素,常用来治疗耐甲氧西林的革兰氏阳性球菌。然而,万古霉素的肾毒性副作用导致剂量限制和缩短给药时间。目的:本研究旨在评估水藏红花的保护作用(番红花)提取vancomycin-induced在大鼠肾毒性。材料与方法:将32只成年雄性Wistar大鼠随机分为4组,每组8只;(我)控制(2)藏红花(80毫克/公斤,ip),(3)万古霉素(200毫克/公斤/ BD, ip)及(iv)万古霉素+藏红花。藏红花治疗于万古霉素给药前24小时开始,持续8天,万古霉素给药时间为7天。分析血清肌酐、尿素氮(BUN)、肾脏丙二醛(MDA)水平、超氧化物歧化酶(SOD)活性及肾组织病理变化。结果:与对照组相比,万古霉素组血清肌酐、尿素氮和肾丙二醛水平显著升高,SOD活性降低。另一方面,藏红花水提物降低了血清肌酐、BUN浓度和肾脏MDA水平,但提高了肾脏SOD活性水平。万古霉素组观察到肾小管破坏、间质水肿、上皮空泡化和上皮脱屑等组织病理学改变。然而,服用藏红花提取物可显著减少对肾脏的损害。结论:氧化应激在万古霉素引起的肾毒性中起重要作用,藏红花提取物对万古霉素引起的脂质过氧化和肾毒性具有明显的肾保护作用。
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引用次数: 1
Intra-rater and Inter-rater Reliability of Quantitative Thigh Muscle Magnetic Resonance Imaging 定量大腿肌肉磁共振成像的内部和内部可靠性
Pub Date : 2019-01-01 DOI: 10.14303/IMAGING-MEDICINE.1000130
J. Schroeder, Patrick Tobler, AnnaLea Stalder, S. Schaedelin, X. Deligianni, J. Reinhardt, M. Gloor, Dirk Fischer Arne Fischmann
Introduction: Quantitative magnetic resonance imaging (MRI) methods to quantify muscle tissue fat content are increasingly used in the evaluation of patients with inherited neuromuscular disorders. Recently, these techniques gained importance to detect disease progression and possible treatment responses. In this study, two widely used fat quantification MRI sequences (two- and three- point Dixon) were applied to assess the reproducibility and reliability of the techniques. Methods: For this clinical trial six healthy volunteers were scanned at a 3T clinical MRI scanner a total of six times on two different days (three times each) using two different fat quantification techniques: a 2-point Dixon (2-PD) and a 3-point Dixon (3-PD) technique. Each time axial sequences of both thighs were acquired. For all repeated scans and subjects a total of 660 muscles of the thighs were segmented with regions of interest (ROI) by two different raters. An interclass correlation coefficient (ICC) was used to compare inter-rater and intra-rater agreement of the different acquisition methods, regarding other potential biases such as repetition and day of the scans. Furthermore, the general accuracy of the different methods was obtained by calculating the fat fraction. Results: For quantitative MRI accessing the fat fraction in the thigh muscles, Dixon sequences have been shown to be very stable in reproducibility with ICCs of >0.9 of both inter-rater and intra-rater agreement, as well as low variability. There was no significant difference between the two sequences regarding reproducibility, although 2-PD Dixon showed a little advantage when measuring small muscles. Conclusion: In conclusion both sequences are useful for assessing fatty muscle degeneration showing a high reproducibility and reliability, with low inter- and intra-rater differences. 2-PD showed a small advantage when measuring small muscles.
定量磁共振成像(MRI)方法定量肌肉组织脂肪含量越来越多地用于评估遗传性神经肌肉疾病患者。最近,这些技术在检测疾病进展和可能的治疗反应方面变得重要起来。在这项研究中,两种广泛使用的脂肪量化MRI序列(两点和三点Dixon)被用于评估该技术的可重复性和可靠性。方法:在这项临床试验中,6名健康志愿者在两个不同的日子(每天3次)使用两种不同的脂肪量化技术(2点Dixon (2-PD)和3点Dixon (3-PD))在3T临床MRI扫描仪上扫描了6次。每次均获得双大腿轴向序列。在所有的重复扫描和受试者中,共有660块大腿肌肉被两个不同的评分者用感兴趣区域(ROI)分割。使用类间相关系数(ICC)比较不同获取方法的类间和类内一致性,考虑到其他潜在偏差,如重复和扫描时间。此外,通过计算脂肪分数,得到了不同方法的一般精度。结果:对于进入大腿肌肉脂肪部分的定量MRI, Dixon序列已被证明具有非常稳定的可重复性,评分间和评分内一致性的ICCs >0.9,以及低变异性。虽然2-PD Dixon在测量小肌肉时表现出一点优势,但两种序列在重复性方面没有显着差异。结论:总之,这两种序列对评估脂肪肌退变具有高重复性和可靠性,具有较低的组间和组内差异。在测量小肌肉时,2-PD显示出很小的优势。
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引用次数: 5
Ossifying lipoma: literature review and analysis of radiological imaging 骨化性脂肪瘤:文献回顾及影像学分析
Pub Date : 2018-01-01 DOI: 10.14303/imaging-medicine.1000103
Bianca R. Rombado, J. Madewell, R. Aslam, B. Mujtaba
Lipomas are benign tumors consisting primarily of mature adipocytes. Imaging is important in distinguishing benign ossifying lipoma from more aggressive tumors such as well-differentiated liposarcomas. Early diagnosis of ossifying lipoma and understanding of its benign etiology prevent unwarranted medical intervention such as biopsies and surgical resection, as well as decrease patient anxiety.
脂肪瘤是主要由成熟脂肪细胞组成的良性肿瘤。影像学对于区分良性骨化性脂肪瘤和其他侵袭性肿瘤(如高分化脂肪肉瘤)非常重要。骨化性脂肪瘤的早期诊断和对其良性病因的了解可以防止不必要的医疗干预,如活检和手术切除,以及减少患者的焦虑。
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引用次数: 3
Mounier kuhn syndrome is another rare cause for a long standing dyspnea 穆尼尔·库恩综合征是另一种罕见的导致长期呼吸困难的原因
Pub Date : 2018-01-01 DOI: 10.14303/IMAGING-MEDICINE.1000120
H. M. Attia
A 63 y old male with long standing history of dyspnea, and recurrent cough and expectoration was initially thought to be suffering from recurrent lower respiratory tract infection (LRTI) and fibrosing alveolitis. The latest plain chest radiograph showed dilated trachea and bronchi in addition to bilateral diffuse interstitial lung disease. The chest CT scan confirmed the abnormally tracheobronchomegaly which was consistent with the diagnosis of the rare Mounier-Kuhn syndrome of an apparently a sporadic form. Such diagnosis should be considered in the differential diagnosis of settings with radiological findings suggestive of LRTI. The case also emphasizes the importance of the size of air passages on the plain chest radiograph.
63岁男性,长期呼吸困难,反复咳嗽和咳痰,最初被认为患有复发性下呼吸道感染(LRTI)和纤维化肺泡炎。最新胸片显示气管和支气管扩张,双侧弥漫性间质性肺病。胸部CT扫描证实异常气管支气管肿大,这与罕见的弥散形式的穆尼尔-库恩综合征的诊断一致。这样的诊断应考虑在鉴别诊断设置与影像学表现提示下呼吸道感染。该病例还强调了胸片平片上空气通道大小的重要性。
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引用次数: 0
Beaver tail liver in evans syndrome due to systemic lupus erythematosus 由系统性红斑狼疮引起的埃文斯综合征的海狸尾肝
Pub Date : 2018-01-01 DOI: 10.14303/IMAGING-MEDICINE.1000107
A. Hm, Imran Khan Khateeb Kal
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引用次数: 0
A Unique Presentation Of Fahr Syndrome Secondary To Chronic Hypoparathyroidism: A Case Report 慢性甲状旁腺功能减退继发Fahr综合征的独特表现:1例报告
Pub Date : 2018-01-01 DOI: 10.14303/IMAGING-MEDICINE.1000114
Alex, E. Chen
Idiopathic basal ganglia calcification, or Fahr Syndrome, often presents in middle-aged patients presenting with parkinsonian symptoms. Unique presentation of young patient presenting with a seizure, and without the presence of parkinsonian symptoms. Imaging revealed near complete calcification of bilateral basal ganglia. Most common etiology of basal ganglia calcification is idiopathic or familial, but may also be secondary to metabolic derangements.
特发性基底神经节钙化,或Fahr综合征,常出现在有帕金森症状的中年患者。年轻患者癫痫发作的独特表现,没有帕金森症状的存在。影像学显示双侧基底节区几乎完全钙化。基底神经节钙化最常见的病因是特发性或家族性,但也可能继发于代谢紊乱。
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引用次数: 1
期刊
Imaging in Medicine
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