Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000108
R. Ouji, N. Achour, I. Kasraoui, O. Mnif
Abdominal actinomycosis is an uncommon abdominal disease caused by Actinomyces species. It may appear as an abdominal mass and it has a tendency to infiltrate adjacent tissues this is why it is often mistaken for a malignant tumor. We report a case of a man who consulted our institution for abdominal pain and a palpable right upper quadrant mass. Computerized tomography (CT) scan showed intra-peritoneal tissue mass with irregular contours that invades the left colon and infiltrates the abdominal oblique muscles. The biopsy under colonoscopy could not eliminate a malignant tumor. A scanner-guided biopsy confirmed the diagnosis of actinomycosis. The sample revealed the presence of voluminous clumps of rounded basophilic germs, filamentous in appearance. High dose IV penicillin therapy was given with complete resolution of symptoms and a complete disappearance of the colonic wall thickening as well as the invasion of the abdominal wall in the CT.
{"title":"Peritoneal pseudotumoral actinomycosis: A case report","authors":"R. Ouji, N. Achour, I. Kasraoui, O. Mnif","doi":"10.14303/IMAGING-MEDICINE.1000108","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000108","url":null,"abstract":"Abdominal actinomycosis is an uncommon abdominal disease caused by Actinomyces species. It may appear as an abdominal mass and it has a tendency to infiltrate adjacent tissues this is why it is often mistaken for a malignant tumor. We report a case of a man who consulted our institution for abdominal pain and a palpable right upper quadrant mass. Computerized tomography (CT) scan showed intra-peritoneal tissue mass with irregular contours that invades the left colon and infiltrates the abdominal oblique muscles. The biopsy under colonoscopy could not eliminate a malignant tumor. A scanner-guided biopsy confirmed the diagnosis of actinomycosis. The sample revealed the presence of voluminous clumps of rounded basophilic germs, filamentous in appearance. High dose IV penicillin therapy was given with complete resolution of symptoms and a complete disappearance of the colonic wall thickening as well as the invasion of the abdominal wall in the CT.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"114 1","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77667728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.100015
Tran Thi Khanh Tuong, N. M. Duc
Objective: This study aimed to investigate the value of liver fibrosis assessment by ARFI and APRI on patients with common chronic liver diseases. Materials and methods: There were 119 patients with chronic hepatitis B and/or C, alcoholic liver disease and non-alcoholic steatohepatitis in this prospective study. All of the patients underwent a liver biopsy for histopathological assessment of liver fibrosis, ARFI and APRI calculation. The results of ARFI and APRI were compared to the histological fibrosis degree. Results: Histopathology of liver fibrosis was evaluated by Metavir score: F0: 9 cases, F1: 57 cases, F2: 23 cases, F3: 19 cases and F4: 11 cases. Shear wave velocity (SWV) significantly correlated with the fibrosis stage (Spearman rho: 0.69, p<0.0001). The area under the ROC curves (AUROCs) for diagnosis of ≥ F2 and ≥ F3 were 0.86 (95% CI: 0.79-0.93) and 0.88 (95% CI: 0.80-0.96), respectively. The cut-off values of SWV for ≥ F2 and ≥ F3 were 1.29 m/s (Se 79.25%, Sp 89.36%, PPV 85.7% and NPV 84.3%) and ≥ 1.36 m/s (Se 96.67%, Sp 86.52%, PPV 70.7%, NPV 98.7%), respectively. APRI significantly correlated with the fibrosis stage (Spearman rho: 0.35, p < 0.0001). AUROCs for diagnosis of ≥ F2 and ≥ F3 were 0.7 (95% CI: 0.56-0.79) and 0.7 (95% CI: 0.85-0.81), respectively. The cut-off values of APRI for diagnosis of ≥ F2 and ≥ F3 were ≥ 0.569 (Se 50.94%, Sp 88.33%, PPV 71.1% and NPV 67.9%) and ≥ 1.163 (Se 40%, Sp 96.63%, PPV 80%, NPV 82.7%), respectively. Conclusions: This study manifested the role of ARFI and APRI as efficacious methods for assessing liver fibrosis on patients with common chronic liver diseases. Increasing SWV and APRI correlates with higher degree of liver fibrosis. ARFI was significantly better than APRI in evaluating the degree of liver fibrosis.
{"title":"The Role Of ARFI And APRI In Diagnosis Of Liver Fibrosis On Patients With Common Chronic Liver Diseases","authors":"Tran Thi Khanh Tuong, N. M. Duc","doi":"10.14303/IMAGING-MEDICINE.100015","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.100015","url":null,"abstract":"Objective: This study aimed to investigate the value of liver fibrosis assessment by ARFI and APRI on patients with common chronic liver diseases. Materials and methods: There were 119 patients with chronic hepatitis B and/or C, alcoholic liver disease and non-alcoholic steatohepatitis in this prospective study. All of the patients underwent a liver biopsy for histopathological assessment of liver fibrosis, ARFI and APRI calculation. The results of ARFI and APRI were compared to the histological fibrosis degree. Results: Histopathology of liver fibrosis was evaluated by Metavir score: F0: 9 cases, F1: 57 cases, F2: 23 cases, F3: 19 cases and F4: 11 cases. Shear wave velocity (SWV) significantly correlated with the fibrosis stage (Spearman rho: 0.69, p<0.0001). The area under the ROC curves (AUROCs) for diagnosis of ≥ F2 and ≥ F3 were 0.86 (95% CI: 0.79-0.93) and 0.88 (95% CI: 0.80-0.96), respectively. The cut-off values of SWV for ≥ F2 and ≥ F3 were 1.29 m/s (Se 79.25%, Sp 89.36%, PPV 85.7% and NPV 84.3%) and ≥ 1.36 m/s (Se 96.67%, Sp 86.52%, PPV 70.7%, NPV 98.7%), respectively. APRI significantly correlated with the fibrosis stage (Spearman rho: 0.35, p < 0.0001). AUROCs for diagnosis of ≥ F2 and ≥ F3 were 0.7 (95% CI: 0.56-0.79) and 0.7 (95% CI: 0.85-0.81), respectively. The cut-off values of APRI for diagnosis of ≥ F2 and ≥ F3 were ≥ 0.569 (Se 50.94%, Sp 88.33%, PPV 71.1% and NPV 67.9%) and ≥ 1.163 (Se 40%, Sp 96.63%, PPV 80%, NPV 82.7%), respectively. Conclusions: This study manifested the role of ARFI and APRI as efficacious methods for assessing liver fibrosis on patients with common chronic liver diseases. Increasing SWV and APRI correlates with higher degree of liver fibrosis. ARFI was significantly better than APRI in evaluating the degree of liver fibrosis.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"14 1","pages":"133-138"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86905231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000112
Sindhu P Kumar
{"title":"Cecal diverticulitis mimicking as appendicitis","authors":"Sindhu P Kumar","doi":"10.14303/IMAGING-MEDICINE.1000112","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000112","url":null,"abstract":"","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"11 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82655309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000092
R. Nishii, T. Hirai, T. Fujii, T. Kumada, T. Higashi, S. Kagawa, Y. Kishibe, Masaaki Takahashi, H. Yamauchi, Chio Okuyama Shigeki Nagamachi
Objectives :- A ketogenic diet (KD) is a strict dietary protocol that incorporates high-fat, low-protein, and low-carbohydrate foods. Increasing the levels of ketones became an eventual and effective treatment strategy for medically refractory epilepsy. Although several theories on the rationale for the anticonvulsant efficacy of KD have been hypothesized, the most important anticonvulsant mechanism of KD is still unknown. This study is the first report that evaluated the mechanism underlying the effect of KD in patients with intractable infantile epilepsy using FMZ-PET imaging studies. Methods :-Six patients with intractable epilepsy (two females/four males; seizure-onset age: 0–30 months) were enrolled in this study. Medication-refractory seizures continued in all patients despite treatment with the anti-epilepsy drugs (AEDs), followed by two types of KD therapy; the classical KD menu or the MAD regimen. All patients underwent FMZ-PET before KD and at 1-5 months after induction of KD. Dynamic FMZ-PET scanning was acquired, followed by assessment of the BP images using the graphic plot method of Logan. Results:- In KD-effective patients, the BPs of FMZ before KD were 1.31, 1.60 and 1.50, and those after induction of KD were 1.89, 2.13 and 2.07, respectively. In KD-partially effective patients, the BPs of FMZ before KD were 1.95 and 2.47, and those after induction of KD were 2.10 and 2.71, respectively. Conversely, in KD-ineffective case, the BP of FMZ was decreased from 3.91 before KD to 3.58. The BP-change ratios were 1.44, 1.33 and 1.38 in the KD-effective patients, 1.08 and 1.10 in the KD-partially effective patients, and 0.92 in the KD-ineffective one. Conclusion;- The results of current study suggested that KD may control seizures by increasing BP of BZR and that FMZ-PET imaging would be useful to assess the efficacy of KD therapy in patients with intractable epilepsy. Using MRI to pre-operatively evaluate breast blood supply is feasible without adding extra MRI time or contrast. 71% had dominant supply to the NAC, so every effort should be made to preserve it. The LOQ appears to be an optimal site for skin incisions. There is an asymmetry between cancer and HRS breasts mainly at the NAC’s level with neovascularization of that area.Patients with a single vessel supplying the NAC are at improved risk for necrosis.
{"title":"FMZ-PET to assess the efficacy and the mechanism of ketogenic diet in patients withintractable epilepsy","authors":"R. Nishii, T. Hirai, T. Fujii, T. Kumada, T. Higashi, S. Kagawa, Y. Kishibe, Masaaki Takahashi, H. Yamauchi, Chio Okuyama Shigeki Nagamachi","doi":"10.14303/IMAGING-MEDICINE.1000092","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000092","url":null,"abstract":"Objectives :- A ketogenic diet (KD) is a strict dietary protocol that incorporates high-fat, low-protein, and low-carbohydrate foods. Increasing the levels of ketones became an eventual and effective treatment strategy for medically refractory epilepsy. Although several theories on the rationale for the anticonvulsant efficacy of KD have been hypothesized, the most important anticonvulsant mechanism of KD is still unknown. This study is the first report that evaluated the mechanism underlying the effect of KD in patients with intractable infantile epilepsy using FMZ-PET imaging studies. Methods :-Six patients with intractable epilepsy (two females/four males; seizure-onset age: 0–30 months) were enrolled in this study. Medication-refractory seizures continued in all patients despite treatment with the anti-epilepsy drugs (AEDs), followed by two types of KD therapy; the classical KD menu or the MAD regimen. All patients underwent FMZ-PET before KD and at 1-5 months after induction of KD. Dynamic FMZ-PET scanning was acquired, followed by assessment of the BP images using the graphic plot method of Logan. Results:- In KD-effective patients, the BPs of FMZ before KD were 1.31, 1.60 and 1.50, and those after induction of KD were 1.89, 2.13 and 2.07, respectively. In KD-partially effective patients, the BPs of FMZ before KD were 1.95 and 2.47, and those after induction of KD were 2.10 and 2.71, respectively. Conversely, in KD-ineffective case, the BP of FMZ was decreased from 3.91 before KD to 3.58. The BP-change ratios were 1.44, 1.33 and 1.38 in the KD-effective patients, 1.08 and 1.10 in the KD-partially effective patients, and 0.92 in the KD-ineffective one. Conclusion;- The results of current study suggested that KD may control seizures by increasing BP of BZR and that FMZ-PET imaging would be useful to assess the efficacy of KD therapy in patients with intractable epilepsy. Using MRI to pre-operatively evaluate breast blood supply is feasible without adding extra MRI time or contrast. 71% had dominant supply to the NAC, so every effort should be made to preserve it. The LOQ appears to be an optimal site for skin incisions. There is an asymmetry between cancer and HRS breasts mainly at the NAC’s level with neovascularization of that area.Patients with a single vessel supplying the NAC are at improved risk for necrosis.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"55 1 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82837590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000098
M. SumantaKumar, Alpana Singh
Nodular thyroid is a common clinical entity. All patients were evaluated by grey scale USG and colour Doppler and then subjected to FNAC. Histopathology was done whenever required. The results were then compared. most of the benign nodules as well as the malignant nodules were predominantly solid or solid-cystic with predominant solid components.
{"title":"Role of Ultrasonography in recognition of malignant potential of thyroid nodules on the basis of their internal composition","authors":"M. SumantaKumar, Alpana Singh","doi":"10.14303/IMAGING-MEDICINE.1000098","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000098","url":null,"abstract":"Nodular thyroid is a common clinical entity. All patients were evaluated by grey scale USG and colour Doppler and then subjected to FNAC. Histopathology was done whenever required. The results were then compared. most of the benign nodules as well as the malignant nodules were predominantly solid or solid-cystic with predominant solid components.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"8 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75353933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000102
Mai Elzahry, H. Sinzinger, B. Palumbo
Abstract : Purpose: Data comparing osteoblastic vs osteolytic recurrences of therapeutic response are still very limited. We aimed to answer this question in 164 female breast cancer patients (including 61 females on statin therapy) suffering from recurrent breast cancer who received a single dose of Sm-153 EDTMP for painful metastatic bone lesions. Methods: 164 female patients suffered from painful metastatic breast cancer with >1 up to 5 bone lesions, we evaluated the response of recurrences judged by CT as osteoblastic (BL), osteolytic (LY) or mixed (MI) showing up in bone scintigraphy to a single dose of 30mci (1.1GBq) 153Sm-EDTMP. 116 females (70.03%) suffered from ductal, 37(22.56%) from lobular, 10 (6.09%) from mixed and 1(0.61%) from medullary cancer. Statin used by the 61 female patients were Simvastatin (20 or 40 mg/day orally), Atorvastatin (20 or 40 mg/day orally) and Rosuvastatin (20 mg/day orally). Results: Bone uptake and pain response did not show any difference between BL-, LY- and MI-recurrences. No correlation of pain response and its duration vs. uptake, type, number and extent of lesions, adhesion molecules (AM) and histology was seen. Out of 164 female cancer breast, females on statins exhibited a significantly (P-value <0.01) more pronounced decrease in adhesion molecules vs. non users. Conclusion: These findings indicate no significant difference in pain response between the different types of bone recurrences. Whether, the effect of statins on adhesion molecules is a direct drug effect or reflect on antitumoral action as well as, the influence on the extent of recurrences should be examined in prospective studies.
{"title":"Therapeutic bone response of breast cancer recurrences on single sm-153 EDTMP treatment (+/- influence of statin intake)","authors":"Mai Elzahry, H. Sinzinger, B. Palumbo","doi":"10.14303/IMAGING-MEDICINE.1000102","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000102","url":null,"abstract":"Abstract : Purpose: Data comparing osteoblastic vs osteolytic recurrences of therapeutic response are still very limited. We aimed to answer this question in 164 female breast cancer patients (including 61 females on statin therapy) suffering from recurrent breast cancer who received a single dose of Sm-153 EDTMP for painful metastatic bone lesions. Methods: 164 female patients suffered from painful metastatic breast cancer with >1 up to 5 bone lesions, we evaluated the response of recurrences judged by CT as osteoblastic (BL), osteolytic (LY) or mixed (MI) showing up in bone scintigraphy to a single dose of 30mci (1.1GBq) 153Sm-EDTMP. 116 females (70.03%) suffered from ductal, 37(22.56%) from lobular, 10 (6.09%) from mixed and 1(0.61%) from medullary cancer. Statin used by the 61 female patients were Simvastatin (20 or 40 mg/day orally), Atorvastatin (20 or 40 mg/day orally) and Rosuvastatin (20 mg/day orally). Results: Bone uptake and pain response did not show any difference between BL-, LY- and MI-recurrences. No correlation of pain response and its duration vs. uptake, type, number and extent of lesions, adhesion molecules (AM) and histology was seen. Out of 164 female cancer breast, females on statins exhibited a significantly (P-value <0.01) more pronounced decrease in adhesion molecules vs. non users. Conclusion: These findings indicate no significant difference in pain response between the different types of bone recurrences. Whether, the effect of statins on adhesion molecules is a direct drug effect or reflect on antitumoral action as well as, the influence on the extent of recurrences should be examined in prospective studies.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"10 1","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77366952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/imaging-medicine.1000111
Maziar Sigary, SeanDeSilva Abin Sajan
Spontaneous abortions are associated with 20 percent of all pregnancies and they are the most common cause of first trimester bleeding. Diagnosis is based on ultrasound findings. Patients typically present with vaginal bleeding and severe lower abdominal pain. We report a 25 year old female with vaginal bleeding, bilateral abdominal pain, and normal transvaginal US findings on admission. Follow-up magnetic resonance imaging in the emergency department demonstrated heterogeneous, T2 isointense/hyperintense signal material extending from the uterine cavity and protruding into the vaginal canal, consistent with active passage of products of conception. Findings were confirmed by pathology and speculum exam.
{"title":"Spontaneous abortion with MRI correlates in the emergency department","authors":"Maziar Sigary, SeanDeSilva Abin Sajan","doi":"10.14303/imaging-medicine.1000111","DOIUrl":"https://doi.org/10.14303/imaging-medicine.1000111","url":null,"abstract":"Spontaneous abortions are associated with 20 percent of all pregnancies and they are the most common cause of first trimester bleeding. Diagnosis is based on ultrasound findings. Patients typically present with vaginal bleeding and severe lower abdominal pain. We report a 25 year old female with vaginal bleeding, bilateral abdominal pain, and normal transvaginal US findings on admission. Follow-up magnetic resonance imaging in the emergency department demonstrated heterogeneous, T2 isointense/hyperintense signal material extending from the uterine cavity and protruding into the vaginal canal, consistent with active passage of products of conception. Findings were confirmed by pathology and speculum exam.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"16 1","pages":"111-115"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74449587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000099
A. Azriel, I. Melamed, Y. Sufaro, A. Cohen, M. Benifla, Nitsan Mendelson Ilan Shelef
Background: Intracranial pathologies often cause elevated intracranial pressure (ICP), which presence may be of great significance regarding the chosen treatment option as well as its timing. Radiography is routinely used to support the clinical diagnosis and to establish the etiology for the elevated ICP. The relation between increased ICP and cerebral venous sinuses dimensions has been previously demonstrated, mainly among patients diagnosed with idiopathic increased ICP. The relation between brain tumors and venous sinuses dimensions has not been established so far. The aim of this study was to investigate the relation between the presence of brain tumors and the characteristics of the large cerebral venous sinuses. Methods: A single center retrospective study was conducted. Patients diagnosed with brain tumors who were surgically treated at our medical center were enrolled. MRI based cerebral venous sinuses measurements were performed, prior to the surgical resection and following it. Results: The research group included 17 patients, primarily women (64%), aged 16-81 years. Brain pathologies included both benign and malignant tumors. The main cerebral venous sinuses were measured at 6 different locations before and after the resection procedure. Among all 6 measuring points there was a significant size increase following the operation. There was no significant difference in the results when addressing different types of tumors or anatomical location. Conclusion: This study presents an additional indirect method of establishing the existence of increased ICP, and emphasizes the role of cerebral venous sinuses in ICP control. Using this method may assist in clinical and radiological evaluation of patients diagnosed with brain tumors.
{"title":"Intracranial Venous Sinuses Characteristics Prior To And Following Resection Of Brain Tumors","authors":"A. Azriel, I. Melamed, Y. Sufaro, A. Cohen, M. Benifla, Nitsan Mendelson Ilan Shelef","doi":"10.14303/IMAGING-MEDICINE.1000099","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000099","url":null,"abstract":"Background: Intracranial pathologies often cause elevated intracranial pressure (ICP), which presence may be of great significance regarding the chosen treatment option as well as its timing. Radiography is routinely used to support the clinical diagnosis and to establish the etiology for the elevated ICP. The relation between increased ICP and cerebral venous sinuses dimensions has been previously demonstrated, mainly among patients diagnosed with idiopathic increased ICP. The relation between brain tumors and venous sinuses dimensions has not been established so far. The aim of this study was to investigate the relation between the presence of brain tumors and the characteristics of the large cerebral venous sinuses. Methods: A single center retrospective study was conducted. Patients diagnosed with brain tumors who were surgically treated at our medical center were enrolled. MRI based cerebral venous sinuses measurements were performed, prior to the surgical resection and following it. Results: The research group included 17 patients, primarily women (64%), aged 16-81 years. Brain pathologies included both benign and malignant tumors. The main cerebral venous sinuses were measured at 6 different locations before and after the resection procedure. Among all 6 measuring points there was a significant size increase following the operation. There was no significant difference in the results when addressing different types of tumors or anatomical location. Conclusion: This study presents an additional indirect method of establishing the existence of increased ICP, and emphasizes the role of cerebral venous sinuses in ICP control. Using this method may assist in clinical and radiological evaluation of patients diagnosed with brain tumors.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"81 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80224269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000113
Bimbadhar Valluru, W. Ran, D. Wei, Y. Jun, Wu Chun Hua Kalyan Sharma
Objective: To investigate the effects of NF-κB and the role of inflammatory response factors on the normal liver tissue around the tumors in rabbit VX2 hepatocellular carcinoma models after TAE. Methods: Seventy VX2 hepatoma rabbit models were prepared and success rate was 85.7%. Computed tomography (CT) and Magnetic resonance imaging (MRI) was performed after 21 days of modelling. Sixty rabbits were randomly chosen and divided into three groups, 20 in each group: TAE group, Contrast/Angiography group, and Control group respectively. TAE group was treated with Transarterial embolization (TAE) and the Contrast group was subjected to hepatic arteriography and DSA, while the Control group served as a control group. The immune-histochemistry analysis was used to detect the expression of NF-κB in normal liver tissue around the tumors of each group. The levels of inflammatory factors like TNF-α, IL-10 of each group were detected by Enzyme-linked immunosorbent assay (ELISA) in the normal liver tissue around the tumor. Using SPSS 22.0 statistical analysis software, measurement data was analyzed using t-test, count data were compared using the χ2-test; P <0.05 was considered as statistically significant. Results: The positive expression rates of NF-κB in the TAE group, contrast group, and control group were 75% (15/20), 35% (7/20) and 20% (4/20) respectively. The concentrations of TNF-α were 11.72 ± 0.65 (ng/L), 9.60 ± 0.31 (ng/L) and 8.82 ± 0.81 (ng/L); the concentrations of IL-10 were 2.18±0.13 (ng/L), 1.67 ± 0.12 (ng/L), 1.66 ± 0.10 (ng/L) respectively. Compared with the control group and contrast groups, TAE group showed a significant increase in the expression of NF-κB, and the levels of TNF-α and IL-10 were also increased. Conclusion: The hepatocytic injury, degrading function after TAE could be due to the interaction of NF-κB and inflammatory factors- TNF-α and IL-10.
{"title":"Effects of NF-kB and the role of inflammatory response factors on the hepatocytic injury after TAE- An experimental study","authors":"Bimbadhar Valluru, W. Ran, D. Wei, Y. Jun, Wu Chun Hua Kalyan Sharma","doi":"10.14303/IMAGING-MEDICINE.1000113","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000113","url":null,"abstract":"Objective: To investigate the effects of NF-κB and the role of inflammatory response factors on the normal liver tissue around the tumors in rabbit VX2 hepatocellular carcinoma models after TAE. Methods: Seventy VX2 hepatoma rabbit models were prepared and success rate was 85.7%. Computed tomography (CT) and Magnetic resonance imaging (MRI) was performed after 21 days of modelling. Sixty rabbits were randomly chosen and divided into three groups, 20 in each group: TAE group, Contrast/Angiography group, and Control group respectively. TAE group was treated with Transarterial embolization (TAE) and the Contrast group was subjected to hepatic arteriography and DSA, while the Control group served as a control group. The immune-histochemistry analysis was used to detect the expression of NF-κB in normal liver tissue around the tumors of each group. The levels of inflammatory factors like TNF-α, IL-10 of each group were detected by Enzyme-linked immunosorbent assay (ELISA) in the normal liver tissue around the tumor. Using SPSS 22.0 statistical analysis software, measurement data was analyzed using t-test, count data were compared using the χ2-test; P <0.05 was considered as statistically significant. Results: The positive expression rates of NF-κB in the TAE group, contrast group, and control group were 75% (15/20), 35% (7/20) and 20% (4/20) respectively. The concentrations of TNF-α were 11.72 ± 0.65 (ng/L), 9.60 ± 0.31 (ng/L) and 8.82 ± 0.81 (ng/L); the concentrations of IL-10 were 2.18±0.13 (ng/L), 1.67 ± 0.12 (ng/L), 1.66 ± 0.10 (ng/L) respectively. Compared with the control group and contrast groups, TAE group showed a significant increase in the expression of NF-κB, and the levels of TNF-α and IL-10 were also increased. Conclusion: The hepatocytic injury, degrading function after TAE could be due to the interaction of NF-κB and inflammatory factors- TNF-α and IL-10.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"69 1","pages":"117-127"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78135066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：