Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000105
N. M. Duc, H. Q. Huy, Mai Tan Lien Bang, L. Truong, Vo Hoang Tri, Bui Nguyen Canh, Pham Ngoc Hoa, P. M. Thong
Based on Brownian motion, diffusion statement of proton hydro inside body is one of the most important variables affected on the diagnosis, treatment planning, and disease response to treatment. There are some different kinds of diffusion-weighted magnetic resonance imaging types such as diffusion-weighted imaging, diffusion tensor imaging, diffusion kurtosis imaging, intravoxel incoherent motion imaging, zoom diffusion imaging, and diffusion spectrum imaging. In this short communication, we aimed to introduce clinical applications of these diffusion-weighted magnetic resonance imaging types.
{"title":"Clinical applications of diffusion-weighted magnetic resonance imaging","authors":"N. M. Duc, H. Q. Huy, Mai Tan Lien Bang, L. Truong, Vo Hoang Tri, Bui Nguyen Canh, Pham Ngoc Hoa, P. M. Thong","doi":"10.14303/IMAGING-MEDICINE.1000105","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000105","url":null,"abstract":"Based on Brownian motion, diffusion statement of proton hydro inside body is one of the most important variables affected on the diagnosis, treatment planning, and disease response to treatment. There are some different kinds of diffusion-weighted magnetic resonance imaging types such as diffusion-weighted imaging, diffusion tensor imaging, diffusion kurtosis imaging, intravoxel incoherent motion imaging, zoom diffusion imaging, and diffusion spectrum imaging. In this short communication, we aimed to introduce clinical applications of these diffusion-weighted magnetic resonance imaging types.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"38 1","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78063226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000104
N. M. Duc, H. Q. Huy, Mai Tan Lien Bang, L. Truong, Pham Ngoc Hoa, P. M. Thong
Perfusion is one of the most important parameters affected on the diagnosis, treatment planning, and disease response to therapy. There are some discriminative kinds of Perfusion-Weighted Imaging (PWI) such as dynamic susceptibility contrast PWI, semiquantitative dynamic contrast-enhanced PWI, quantitative dynamic contrast-enhanced PWI, dynamic glucose-enhanced PWI, arterial spin labelling and amide proton transfer. In this short communication, we aimed to introduce clinical approach of these PWI types.
{"title":"Clinical approach of perfusion-weighted imaging","authors":"N. M. Duc, H. Q. Huy, Mai Tan Lien Bang, L. Truong, Pham Ngoc Hoa, P. M. Thong","doi":"10.14303/IMAGING-MEDICINE.1000104","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000104","url":null,"abstract":"Perfusion is one of the most important parameters affected on the diagnosis, treatment planning, and disease response to therapy. There are some discriminative kinds of Perfusion-Weighted Imaging (PWI) such as dynamic susceptibility contrast PWI, semiquantitative dynamic contrast-enhanced PWI, quantitative dynamic contrast-enhanced PWI, dynamic glucose-enhanced PWI, arterial spin labelling and amide proton transfer. In this short communication, we aimed to introduce clinical approach of these PWI types.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"51 1","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75956760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/imaging-medicine.1000124
N. M. Duc, H. Q. Huy, Pham Ngoc Hoa, P. Duc, Nguyễn Phước Bảo Quân, P. M. Thong, Nguyen Dinh Tuan, Vu Long, Hoang Duc Kiet, Hoang Minh Loi Bilgin Keserci
High-intensity focused ultrasound surgery is a potential non-invasive surgery for eliminating leiomyoma. In this short communication, we introduced an alternative role of this method for cases of multiple leiomyomas and huge leiomyomas with effective outcomes along with the pros and cons of these findings.
{"title":"MRI-guided High-intensity Focused Ultrasound As An Alternative Treatment Option For Multiple Leiomyomas And Huge Leiomyomas","authors":"N. M. Duc, H. Q. Huy, Pham Ngoc Hoa, P. Duc, Nguyễn Phước Bảo Quân, P. M. Thong, Nguyen Dinh Tuan, Vu Long, Hoang Duc Kiet, Hoang Minh Loi Bilgin Keserci","doi":"10.14303/imaging-medicine.1000124","DOIUrl":"https://doi.org/10.14303/imaging-medicine.1000124","url":null,"abstract":"High-intensity focused ultrasound surgery is a potential non-invasive surgery for eliminating leiomyoma. In this short communication, we introduced an alternative role of this method for cases of multiple leiomyomas and huge leiomyomas with effective outcomes along with the pros and cons of these findings.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"2001 1","pages":"165-171"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88299949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/Imaging-Medicine.1000093
S. Elsirgany, S. Salama, M. Aboulghar
Iniencephaly is characterized by severe retro flexion of the head with the absence of neck due to spinal vertebrae deformities, it is considered as uncommon anomaly. Prevalence: 0.1-10:10,000, M:F. Etiology: Unknown, but genetic, environmental factors are implicated. Pathogenesis: Unknown. Recurrence risk: 1-4%. Associated anomalies: Anencephaly, encephalocele, cyclopedia, lack of lower jaw bone, cleft palate, arthrogryposis, clubfeet, holoprosencephaly, spina bifida, lung hypoplasia, omphalocele, gastroschisis, cardiovascular disorders, Congenital diaphragmatic hernias, gastrointestinal atresia, single umbilical artery and renal abnormalities. Conclusion: Iniencephaly is a lethal congenital neural tube malformation. It is characterized by occipital bone defect, fixed retroflexion of the fetal head and severe lordosis of the cervicothoracic spine. Differential diagnosis: Include anencephaly with cervical spinal retro flexion and Klippel-Fiel syndrome
{"title":"A rare case of a fetal neural tube defect: Iniencephaly","authors":"S. Elsirgany, S. Salama, M. Aboulghar","doi":"10.14303/Imaging-Medicine.1000093","DOIUrl":"https://doi.org/10.14303/Imaging-Medicine.1000093","url":null,"abstract":"Iniencephaly is characterized by severe retro flexion of the head with the absence of neck due to spinal vertebrae deformities, it is considered as uncommon anomaly. Prevalence: 0.1-10:10,000, M:F. Etiology: Unknown, but genetic, environmental factors are implicated. Pathogenesis: Unknown. Recurrence risk: 1-4%. Associated anomalies: Anencephaly, encephalocele, cyclopedia, lack of lower jaw bone, cleft palate, arthrogryposis, clubfeet, holoprosencephaly, spina bifida, lung hypoplasia, omphalocele, gastroschisis, cardiovascular disorders, Congenital diaphragmatic hernias, gastrointestinal atresia, single umbilical artery and renal abnormalities. Conclusion: Iniencephaly is a lethal congenital neural tube malformation. It is characterized by occipital bone defect, fixed retroflexion of the fetal head and severe lordosis of the cervicothoracic spine. Differential diagnosis: Include anencephaly with cervical spinal retro flexion and Klippel-Fiel syndrome","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"57 4 1","pages":"17-19"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86792493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/imaging-medicine.1000090
Toma S Omofoye, Jay R Parikh Megan Kalambo
Regional breast cancer staging with axillary lymph node biopsy has been in the spotlight in recent years following results of the American College of Surgeons Oncology Group (ACOSOG) Z1011 trial. Subsequent studies have demonstrated that clip marker placement in biopsy proven metastatic axillary lymph nodes aids in targeted axillary lymph node dissection, ensuring excision of known metastatic disease and reducing the false negative rate of sentinel lymph node biopsy. We believe the use of DBT for documentation of axillary lymph node clip marker placement presents an opportunity to expand on the established benefits of this new technology. DBT can provide three-dimensional assessment of axillary clip marker placement, assists future follow-up and localization, improves workflow efficiency, helps potentially reduce patient dose and enhances the patient experience.
{"title":"The utility of digital breast tomosynthesis in axillary lymph node post clip mammography","authors":"Toma S Omofoye, Jay R Parikh Megan Kalambo","doi":"10.14303/imaging-medicine.1000090","DOIUrl":"https://doi.org/10.14303/imaging-medicine.1000090","url":null,"abstract":"Regional breast cancer staging with axillary lymph node biopsy has been in the spotlight in recent years following results of the American College of Surgeons Oncology Group (ACOSOG) Z1011 trial. Subsequent studies have demonstrated that clip marker placement in biopsy proven metastatic axillary lymph nodes aids in targeted axillary lymph node dissection, ensuring excision of known metastatic disease and reducing the false negative rate of sentinel lymph node biopsy. We believe the use of DBT for documentation of axillary lymph node clip marker placement presents an opportunity to expand on the established benefits of this new technology. DBT can provide three-dimensional assessment of axillary clip marker placement, assists future follow-up and localization, improves workflow efficiency, helps potentially reduce patient dose and enhances the patient experience.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"55 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87114180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000095
M. S. Aguilar
{"title":"Intrathoracic kidney: a rare finding in an infrequent syndrome","authors":"M. S. Aguilar","doi":"10.14303/IMAGING-MEDICINE.1000095","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000095","url":null,"abstract":"","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91140443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000122
Tran Thi Khanh Tuong, Nguyen Thi Ngoc Anh
Objectives: Cirrhosis accounts for 85% of the causes of ascites besides other causes such as malignancy, heart failure, tuberculosis, etc. Ascitic fluid analysis is one of the most important tests to diagnose causes of ascites. However, this is an invasive procedure. Acoustic Radiation Force Impulse (ARFI) is a new measurement of elastography which can diagnose cirrhosis in patients with ascites. This study evaluates the value of ARFI for initial diagnosis of ascites due to cirrhosis or not due to cirrhosis. Materials and methods: Institutional review board approved this cross-sectional study. The study was carried out on 90 patients with ascites. All patients diagnosed with ascites at Nguyen Trai hospital and Clinic of Pham Ngoc Thach University of Medicine were enrolled from January 2013 to October 2018. All patients underwent ARFI and ascitic fluid analysis. Results: The rate of cirrhotic and non-cirrhotic etiology of ascites were 84.4% and 15.6%, respectively The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites: 3.84 m/s ± 1.43 v/s 1.48 m/s ± 0.55 (p<0.001). In our study, AUROC had a validity of 92.1% with 95% CI= 0.963–0.982 to diagnose of cirrhotic ascites. For an optimal cut-off value of 2.2 m/s for predicting cirrhosis and ascites in the context of cirrhosis, ARFI had sensitivity of 98%, specificity of 66.7%, positive predictive value of 94.3%, negative predictive value of 85.7% for predicting cirrhotic ascites. Conclusion: ARFI elastography was feasible in all patients with ascites. It had a high performance for diagnosis of cirrhosis (AUROC >0.9) andan effective differentiation between the cirrhotic and non-cirrhotic cause of ascites.
{"title":"The Value Of Acoustic Radiation Force Impulse Elastography In Differentiating Cirrhotic And Non-cirrhotic Ascites","authors":"Tran Thi Khanh Tuong, Nguyen Thi Ngoc Anh","doi":"10.14303/IMAGING-MEDICINE.1000122","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000122","url":null,"abstract":"Objectives: Cirrhosis accounts for 85% of the causes of ascites besides other causes such as malignancy, heart failure, tuberculosis, etc. Ascitic fluid analysis is one of the most important tests to diagnose causes of ascites. However, this is an invasive procedure. Acoustic Radiation Force Impulse (ARFI) is a new measurement of elastography which can diagnose cirrhosis in patients with ascites. This study evaluates the value of ARFI for initial diagnosis of ascites due to cirrhosis or not due to cirrhosis. Materials and methods: Institutional review board approved this cross-sectional study. The study was carried out on 90 patients with ascites. All patients diagnosed with ascites at Nguyen Trai hospital and Clinic of Pham Ngoc Thach University of Medicine were enrolled from January 2013 to October 2018. All patients underwent ARFI and ascitic fluid analysis. Results: The rate of cirrhotic and non-cirrhotic etiology of ascites were 84.4% and 15.6%, respectively The mean liver stiffness measurements by means of ARFI were statistically significantly higher in patients with cirrhotic ascites than in those with non-cirrhotic ascites: 3.84 m/s ± 1.43 v/s 1.48 m/s ± 0.55 (p<0.001). In our study, AUROC had a validity of 92.1% with 95% CI= 0.963–0.982 to diagnose of cirrhotic ascites. For an optimal cut-off value of 2.2 m/s for predicting cirrhosis and ascites in the context of cirrhosis, ARFI had sensitivity of 98%, specificity of 66.7%, positive predictive value of 94.3%, negative predictive value of 85.7% for predicting cirrhotic ascites. Conclusion: ARFI elastography was feasible in all patients with ascites. It had a high performance for diagnosis of cirrhosis (AUROC >0.9) andan effective differentiation between the cirrhotic and non-cirrhotic cause of ascites.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"1 1","pages":"155-158"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73114851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/Imaging-Medicine.1000094
R. Fusco, A. Petrillo, S. Setola, V. Granata, N. Raiano, P. Delprete, G. Quarto, Aless, ro Izzo Sisto Perdona
Purpose: To assess the diagnostic performance of multiparametric MRI (mpMRI), in the detection of prostate cancer in two different coil setting: endorectal coil (ERC) versus phased array coil alone (PAC). Materials and Methods: The study included 302 out of 395 consecutive patients with PSA values between 2.5-4 ng/ml and an abnormal Digital Rectal Examination (DRE), or patients with PSA values between 4-10ng/ml, independently from DRE. Each patient provided informed consent to undergo at serum free/total PSA ratio (f/t PSA) assay, morphological MRI (mMRI), DWI, MRS, and Trans Rectal Ultrasonography (TRUS) biopsy. The MRI data sets were scored singularly and then mMRI, DWI and MRS data were combined in a single score (cMRI score). cMRI score was correlated to negative biopsies and Gleason score biopsies. ROC curve and McNemar tests were performed. Results: cMRI score showed high value of sensitivity and NPV for both coil setting (84% and 93% respectively using ERC, 87% and 87% respectively using PAC). cMRI score using ERC did not show statistical superiority compared with cMRI score using PAC alone (p value at McNemar test > 0.05). A significant correlation was obtained comparing the cMRI score to the Gleason score for both coil conditions. Conclusions: Pelvic phased array coil imaging of the prostate produces high quality images and the overall performance in prostate cancer detection is equal than those obtained with endorectal coil imaging.
{"title":"A multiparametric MRI score for prostate cancer detection: Performance in patients with and without endorectal coil","authors":"R. Fusco, A. Petrillo, S. Setola, V. Granata, N. Raiano, P. Delprete, G. Quarto, Aless, ro Izzo Sisto Perdona","doi":"10.14303/Imaging-Medicine.1000094","DOIUrl":"https://doi.org/10.14303/Imaging-Medicine.1000094","url":null,"abstract":"Purpose: To assess the diagnostic performance of multiparametric MRI (mpMRI), in the detection of prostate cancer in two different coil setting: endorectal coil (ERC) versus phased array coil alone (PAC). Materials and Methods: The study included 302 out of 395 consecutive patients with PSA values between 2.5-4 ng/ml and an abnormal Digital Rectal Examination (DRE), or patients with PSA values between 4-10ng/ml, independently from DRE. Each patient provided informed consent to undergo at serum free/total PSA ratio (f/t PSA) assay, morphological MRI (mMRI), DWI, MRS, and Trans Rectal Ultrasonography (TRUS) biopsy. The MRI data sets were scored singularly and then mMRI, DWI and MRS data were combined in a single score (cMRI score). cMRI score was correlated to negative biopsies and Gleason score biopsies. ROC curve and McNemar tests were performed. Results: cMRI score showed high value of sensitivity and NPV for both coil setting (84% and 93% respectively using ERC, 87% and 87% respectively using PAC). cMRI score using ERC did not show statistical superiority compared with cMRI score using PAC alone (p value at McNemar test > 0.05). A significant correlation was obtained comparing the cMRI score to the Gleason score for both coil conditions. Conclusions: Pelvic phased array coil imaging of the prostate produces high quality images and the overall performance in prostate cancer detection is equal than those obtained with endorectal coil imaging.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"86 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81602812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000123
Tran Thi Khanh Tuong Nguyen Minh Duc
Objectives: Liver biopsy is the gold standard for diagnosing the extent of fibrosis in NAFLD/NASH; however, it is invasive with the risk of serious complications. This study aimed to validate the diagnostic usefulness of FIB4, NAFLD Fibrosis Score (NFS), FibroScan and ARFI in assessing liver ?brosis in patients with NAFLD/NASH. Patients and Methods: The study was carried out on 101 patients with NASH. All patients underwent a liver biopsy for histological assessment of liver fibrosis and non-invasive methods for assessment of liver fibrosis including FIB4, NFS, FibroScan, and ARFI. Cut-off values along with the diagnostic accuracy of these methods were determined by receiver-operating characteristic (ROC) curves. Results: Histological liver fibrosis was evaluated by Metavir scoring (F0: 10 cases; F1: 47 cases; F2: 24 cases; F3: 17 cases; and F4: 3 cases). Liver stiffness determined by FIB4, NFS, FibroScan, and ARFI were significantly correlated with the fibrosis stages (Spearman rho: 0.32; 0.51; 0.56 and 0.54; p<0.05, respectively). AUROC of FIB4, NFS, FibroScan and ARFI for diagnosing ≥ F3 were 0.6, 0.8, 0.8, and 0.9, respectively. FibroScan, ARFI v/s NFS were more accurate than FIB4 for diagnosing ≥ F3 (p<0.05). Among those, NFS had the highest sensitivity for diagnoses of ≥ F3. The specificity values of NFS, ARFI and TE were greater than 80% for diagnosing ≥ F3. Conclusions: Liver stiffness determined by these methods had significantly correlated with the fibrosis stages. FibroScan and ARFI had more accurate than NFS and FIB4 in diagnosis of advanced fibrosis. NFS was the best method for screening advanced fibrosis (≥ F3) in patients with NASH.
{"title":"The Role Of Non-Invasive Methods In Evaluating Liver Fibrosis Of Patients With Non-Alcoholic Steatohepatitis","authors":"Tran Thi Khanh Tuong Nguyen Minh Duc","doi":"10.14303/IMAGING-MEDICINE.1000123","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000123","url":null,"abstract":"Objectives: Liver biopsy is the gold standard for diagnosing the extent of fibrosis in NAFLD/NASH; however, it is invasive with the risk of serious complications. This study aimed to validate the diagnostic usefulness of FIB4, NAFLD Fibrosis Score (NFS), FibroScan and ARFI in assessing liver ?brosis in patients with NAFLD/NASH. Patients and Methods: The study was carried out on 101 patients with NASH. All patients underwent a liver biopsy for histological assessment of liver fibrosis and non-invasive methods for assessment of liver fibrosis including FIB4, NFS, FibroScan, and ARFI. Cut-off values along with the diagnostic accuracy of these methods were determined by receiver-operating characteristic (ROC) curves. Results: Histological liver fibrosis was evaluated by Metavir scoring (F0: 10 cases; F1: 47 cases; F2: 24 cases; F3: 17 cases; and F4: 3 cases). Liver stiffness determined by FIB4, NFS, FibroScan, and ARFI were significantly correlated with the fibrosis stages (Spearman rho: 0.32; 0.51; 0.56 and 0.54; p<0.05, respectively). AUROC of FIB4, NFS, FibroScan and ARFI for diagnosing ≥ F3 were 0.6, 0.8, 0.8, and 0.9, respectively. FibroScan, ARFI v/s NFS were more accurate than FIB4 for diagnosing ≥ F3 (p<0.05). Among those, NFS had the highest sensitivity for diagnoses of ≥ F3. The specificity values of NFS, ARFI and TE were greater than 80% for diagnosing ≥ F3. Conclusions: Liver stiffness determined by these methods had significantly correlated with the fibrosis stages. FibroScan and ARFI had more accurate than NFS and FIB4 in diagnosis of advanced fibrosis. NFS was the best method for screening advanced fibrosis (≥ F3) in patients with NASH.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"60 2 1","pages":"159-163"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89209999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-01DOI: 10.14303/IMAGING-MEDICINE.1000110
Yu Yao, Akiko Nagasawa, A. Kakegawa, Masahiro Kato, S. Sakatani
Objectives: Evaluation of Intraductal Components (ICs) of breast cancer, such as ductal extension or segmental distribution, is essential before surgery. Evaluation is mainly performed using contrast-enhanced MRI as its sensitivity and detectability are superior to those of contrast-enhanced CT. Dual Energy CT (DECT) has been shown to have a high contrast enhancement effect with high resolution in soft tissues such as breast tissue. Thus, we assessed the utility of DECT for evaluating an IC of breast cancer. Methods: Fifty-five patients with a biopsy-proven breast cancer have undergone contrast-enhanced DECT and MRI for preoperative investigation. We compared the imaging findings of both modalities and correlated them with the pathological outcome. Results: Pathologically, an IC of breast cancer was identified in 26 patients. Existence of an IC was identified in 32 patients on DECT and 35 patients on MRI. The sensitivity, specificity and accuracy for detecting an IC were 76.9%, 58.6% and 67.3% with DECT and were 73.1%, 44.8%, and 58.2% with MRI, respectively. Conclusions: The appearance of ICs on DECT was highly correlated with the pathological outcome. The advantages of DECT include high detectability of an IC, clinically acceptable image quality, imaging in the face-up position (consistent with the surgical position) and simultaneous assessment of distant metastasis without radiation dose penalty. Thus, DECT is a useful supporting modality for the detection of an IC of breast cancer.
{"title":"An attempt to evaluate intraductal components of breast cancer by dual energy computed tomography","authors":"Yu Yao, Akiko Nagasawa, A. Kakegawa, Masahiro Kato, S. Sakatani","doi":"10.14303/IMAGING-MEDICINE.1000110","DOIUrl":"https://doi.org/10.14303/IMAGING-MEDICINE.1000110","url":null,"abstract":"Objectives: Evaluation of Intraductal Components (ICs) of breast cancer, such as ductal extension or segmental distribution, is essential before surgery. Evaluation is mainly performed using contrast-enhanced MRI as its sensitivity and detectability are superior to those of contrast-enhanced CT. Dual Energy CT (DECT) has been shown to have a high contrast enhancement effect with high resolution in soft tissues such as breast tissue. Thus, we assessed the utility of DECT for evaluating an IC of breast cancer. Methods: Fifty-five patients with a biopsy-proven breast cancer have undergone contrast-enhanced DECT and MRI for preoperative investigation. We compared the imaging findings of both modalities and correlated them with the pathological outcome. Results: Pathologically, an IC of breast cancer was identified in 26 patients. Existence of an IC was identified in 32 patients on DECT and 35 patients on MRI. The sensitivity, specificity and accuracy for detecting an IC were 76.9%, 58.6% and 67.3% with DECT and were 73.1%, 44.8%, and 58.2% with MRI, respectively. Conclusions: The appearance of ICs on DECT was highly correlated with the pathological outcome. The advantages of DECT include high detectability of an IC, clinically acceptable image quality, imaging in the face-up position (consistent with the surgical position) and simultaneous assessment of distant metastasis without radiation dose penalty. Thus, DECT is a useful supporting modality for the detection of an IC of breast cancer.","PeriodicalId":13333,"journal":{"name":"Imaging in Medicine","volume":"23 1","pages":"103-110"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78965606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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