Pub Date : 2024-08-18DOI: 10.1007/s43465-024-01235-y
R. Strain, P. J. Harwood, N. K. Kanakaris, P. V. Giannoudis
Purpose
Non-union is a significant complication following open diaphyseal tibia fractures. Management can be complex and unpredictable. Several principles must be addressed often in combination to achieve union. The aim of this study is to report on the characteristics, management and eventual outcome of non-united open tibial fractures over a 12-year period from a level I trauma centre.
Methods
This is a retrospective observational study of all adults (age 18 years and older) presenting to a level 1 trauma centre with a diaphyseal tibia fracture. Non-union was diagnosed using the standard FDA definition of incomplete union by 9 months or no progress to union in the preceding 3 months. Injury and patient demographics in addition to all interventions and complications were recorded for each patient.
Results
Forty three cases of diaphyseal non-union were identified from 2008 to 2019. Only the presence of peripheral vascular disease demonstrated a statistically significant association with the development of non-union. In 44% of cases, more than one additional operation was required to achieve union. Successful union was achieved in 90% of cases with 74% of patients returning to full pre-injury function without complication.
Conclusion
Management of non-union is a complex problem which requires a multifaceted and bespoke approach. We have included an algorithm to help guide decision making based on our institutional experience. A satisfactory result is achievable in the majority of patients.
目的 非愈合是开放性胫骨骨骺骨折后的一个重要并发症。处理方法可能复杂且难以预测。要实现骨折的愈合,必须结合多种原则。本研究旨在报告一家一级创伤中心 12 年来开放性胫骨骨折不愈合的特点、处理方法和最终结果。方法这是一项回顾性观察研究,研究对象是所有因胫骨骺骨折到一级创伤中心就诊的成年人(18 岁及以上)。根据 FDA 的标准定义,9 个月内未完全愈合或前 3 个月内未达到愈合,即可诊断为非愈合。除了所有干预措施和并发症外,还记录了每位患者的伤情和患者人口统计学特征。结果从2008年到2019年,共发现了43例胫骨骺不愈合病例。只有存在外周血管疾病的病例与非骨骺形成有显著的统计学关联。在44%的病例中,需要进行一次以上的额外手术才能实现连接。90%的病例成功实现了骨结合,74%的患者在无并发症的情况下恢复了受伤前的全部功能。我们根据本机构的经验制定了一套算法,用于指导决策。大多数患者都能获得满意的结果。
{"title":"Treatment of Diaphyseal Tibial Non-unions After Open Fracture: A Retrospective Observational Study on Characteristics and Outcomes","authors":"R. Strain, P. J. Harwood, N. K. Kanakaris, P. V. Giannoudis","doi":"10.1007/s43465-024-01235-y","DOIUrl":"https://doi.org/10.1007/s43465-024-01235-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Non-union is a significant complication following open diaphyseal tibia fractures. Management can be complex and unpredictable. Several principles must be addressed often in combination to achieve union. The aim of this study is to report on the characteristics, management and eventual outcome of non-united open tibial fractures over a 12-year period from a level I trauma centre.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This is a retrospective observational study of all adults (age 18 years and older) presenting to a level 1 trauma centre with a diaphyseal tibia fracture. Non-union was diagnosed using the standard FDA definition of incomplete union by 9 months or no progress to union in the preceding 3 months. Injury and patient demographics in addition to all interventions and complications were recorded for each patient.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Forty three cases of diaphyseal non-union were identified from 2008 to 2019. Only the presence of peripheral vascular disease demonstrated a statistically significant association with the development of non-union. In 44% of cases, more than one additional operation was required to achieve union. Successful union was achieved in 90% of cases with 74% of patients returning to full pre-injury function without complication.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Management of non-union is a complex problem which requires a multifaceted and bespoke approach. We have included an algorithm to help guide decision making based on our institutional experience. A satisfactory result is achievable in the majority of patients.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"2 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-17eCollection Date: 2024-11-01DOI: 10.1007/s43465-024-01238-9
Amit Meena, Manish Attri, Sachin Tapasvi
{"title":"Is Multiligament Knee Injury (MLKI) Still a Challenge in 2024?","authors":"Amit Meena, Manish Attri, Sachin Tapasvi","doi":"10.1007/s43465-024-01238-9","DOIUrl":"10.1007/s43465-024-01238-9","url":null,"abstract":"","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"58 11","pages":"1509-1511"},"PeriodicalIF":1.1,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11555185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-17DOI: 10.1007/s43465-024-01227-y
Isabel Barber-Vidal, Ignacio Miranda, Francisco J. Miranda
Background
There is a broad consensus among orthopedic surgeons in the treatment of Gartland type I supracondylar humerus fractures (conservative) and Gartland type III (surgical) fractures, but there is controversy regarding the treatment of choice for Gartland type II fractures. The aim was to analyze the existing current evidence on the choice of surgical or conservative treatment of Gartland type II supracondylar humerus fractures.
Methods
A systematic review was carried out following the PRISMA guidelines. The search was conducted on May 24, 2023, in PubMed and Cochrane Central, introducing the terms (“humerus” AND “supracondylar”) AND (“Gartland II” OR “Gartland 2”). The selected studies were evaluated with the JBI checklist for quasi-experimental studies.
Results
5 retrospective comparative studies were included (evidence level III). Radiological and functional results were good with both treatments. Only one study obtained a better result with surgical treatment (with n = 4 in the conservative group); the other four studies did not find significant differences between the two types of treatment. There are risks of bias in all studies.
Conclusions
Both types of treatment (conservative and surgical) are valid for type II Gartland supracondylar humerus fractures, and provide good results, both functional and radiological. There is not enough scientific evidence to be able to affirm that one of the two treatments (surgical or conservative) is superior to the other for the treatment of these fractures. Findings on the initial radiograph, such as rotational deformity, coronal malalignment, or a severely angulated distal humeral fragment, can assist in the decision-making process.
背景矫形外科医生在治疗 Gartland I 型肱骨髁上骨折(保守治疗)和 Gartland III 型骨折(手术治疗)方面已达成广泛共识,但在 Gartland II 型骨折的治疗选择上仍存在争议。本研究旨在分析目前关于Gartland II型肱骨髁上骨折选择手术治疗还是保守治疗的现有证据。检索于 2023 年 5 月 24 日在 PubMed 和 Cochrane Central 进行,检索词为("肱骨 "和 "肱骨髁上")和("Gartland II" 或 "Gartland 2")。结果纳入了 5 项回顾性比较研究(证据等级 III)。两种治疗方法的放射学和功能效果都很好。只有一项研究发现手术治疗的效果更好(保守治疗组 n = 4);其他四项研究均未发现两种治疗方法之间存在显著差异。结论两种治疗方法(保守治疗和手术治疗)均适用于II型Gartland肱骨髁上骨折,在功能和放射学方面均有良好效果。目前还没有足够的科学证据证明两种治疗方法(手术或保守)中的一种在治疗此类骨折方面优于另一种。初始X光片上的发现,如旋转畸形、冠状位错位或严重成角的肱骨远端碎片,可有助于决策过程。
{"title":"Orthopedic or Surgical Treatment in Gartland Type II Supracondylar Humerus Fractures: A Systematic Review","authors":"Isabel Barber-Vidal, Ignacio Miranda, Francisco J. Miranda","doi":"10.1007/s43465-024-01227-y","DOIUrl":"https://doi.org/10.1007/s43465-024-01227-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>There is a broad consensus among orthopedic surgeons in the treatment of Gartland type I supracondylar humerus fractures (conservative) and Gartland type III (surgical) fractures, but there is controversy regarding the treatment of choice for Gartland type II fractures. The aim was to analyze the existing current evidence on the choice of surgical or conservative treatment of Gartland type II supracondylar humerus fractures.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A systematic review was carried out following the PRISMA guidelines. The search was conducted on May 24, 2023, in PubMed and Cochrane Central, introducing the terms (“humerus” AND “supracondylar”) AND (“Gartland II” OR “Gartland 2”). The selected studies were evaluated with the JBI checklist for quasi-experimental studies.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>5 retrospective comparative studies were included (evidence level III). Radiological and functional results were good with both treatments. Only one study obtained a better result with surgical treatment (with <i>n</i> = 4 in the conservative group); the other four studies did not find significant differences between the two types of treatment. There are risks of bias in all studies.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Both types of treatment (conservative and surgical) are valid for type II Gartland supracondylar humerus fractures, and provide good results, both functional and radiological. There is not enough scientific evidence to be able to affirm that one of the two treatments (surgical or conservative) is superior to the other for the treatment of these fractures. Findings on the initial radiograph, such as rotational deformity, coronal malalignment, or a severely angulated distal humeral fragment, can assist in the decision-making process.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"181 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-17DOI: 10.1007/s43465-024-01232-1
Adarsh Annapareddy, Praharsha Mulpur, Tarun Jayakumar, Chethan Shinde, Vemaganti Badri Narayana Prasad, A. V. Gurava Reddy
Purpose
This study investigates the radiological outcomes of robotic-assisted total hip arthroplasty (RATHA) compared to manual total hip arthroplasty (mTHA), addressing the ongoing debate on the effectiveness of RATHA in achieving superior implant positioning accuracy.
Methods
A prospective cohort of 212 patients (103 robotic, 109 manual) underwent THA and were evaluated for postoperative radiological outcomes, focusing on the inclination and anteversion angles of the acetabular cup. Outlier prevalence was assessed based on angles outside the defined Lewinnek safe zones. All post-operative measurements were made using the BoneNinja application.
Results
High inter-observer and intra-observer reliabilities were observed, validating the measurement accuracy. The mean anteversion and inclination angles in the RATHA cohort were 40.5 ± 1.5 and 24.5 ± 3.1° respectively; and the mTHA cohort were 42.1 ± 4.9 and 24.9 ± 4.5°. There was a statistically significant difference in inclination angles between the two cohorts whereas the anteversion angles showed no difference. Majority of the conventional THRs (N = 72, 55.4%) were placed outside the safe zone for anteversion. The inclination angles revealed a highly significant difference between the cohorts (p < 0.0001), with all the robotic THRs (N = 121, 100%) being placed within the safe zone for inclination, whereas only 70% (N = 91) of the conventional THRs were within the safe zone. 97.5% of RA-THRs were within 3° of the proposed plan, demonstrating high accuracy.
Conclusion
RATHA significantly outperforms MTHA in radiological accuracy, achieving precise acetabular cup positioning with minimal outliers. These results advocate for RATHA's adoption in THA to enhance outcome predictability and affirm its reliability and safety over manual methods.
{"title":"A Radiological Comparison of Robotic-Assisted Versus Manual Techniques in Total Hip Arthroplasty","authors":"Adarsh Annapareddy, Praharsha Mulpur, Tarun Jayakumar, Chethan Shinde, Vemaganti Badri Narayana Prasad, A. V. Gurava Reddy","doi":"10.1007/s43465-024-01232-1","DOIUrl":"https://doi.org/10.1007/s43465-024-01232-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study investigates the radiological outcomes of robotic-assisted total hip arthroplasty (RATHA) compared to manual total hip arthroplasty (mTHA), addressing the ongoing debate on the effectiveness of RATHA in achieving superior implant positioning accuracy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A prospective cohort of 212 patients (103 robotic, 109 manual) underwent THA and were evaluated for postoperative radiological outcomes, focusing on the inclination and anteversion angles of the acetabular cup. Outlier prevalence was assessed based on angles outside the defined Lewinnek safe zones. All post-operative measurements were made using the BoneNinja application.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>High inter-observer and intra-observer reliabilities were observed, validating the measurement accuracy. The mean anteversion and inclination angles in the RATHA cohort were 40.5 ± 1.5 and 24.5 ± 3.1° respectively; and the mTHA cohort were 42.1 ± 4.9 and 24.9 ± 4.5°. There was a statistically significant difference in inclination angles between the two cohorts whereas the anteversion angles showed no difference. Majority of the conventional THRs (<i>N</i> = 72, 55.4%) were placed outside the safe zone for anteversion. The inclination angles revealed a highly significant difference between the cohorts (<i>p</i> < 0.0001), with all the robotic THRs (<i>N</i> = 121, 100%) being placed within the safe zone for inclination, whereas only 70% (<i>N</i> = 91) of the conventional THRs were within the safe zone. 97.5% of RA-THRs were within 3° of the proposed plan, demonstrating high accuracy.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>RATHA significantly outperforms MTHA in radiological accuracy, achieving precise acetabular cup positioning with minimal outliers. These results advocate for RATHA's adoption in THA to enhance outcome predictability and affirm its reliability and safety over manual methods.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"20 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142217161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05DOI: 10.1007/s43465-024-01218-z
Yuvarajan Palanisamy, Arjun R. Prasad, Karthik Seetharaman, K. Ganesan, M. Kavitha, David V. Rajan
Introduction
Rehabilitation after Total Knee Arthroplasty (TKA) often includes proprioceptive exercises to prevent falls, but studies on proprioceptive training have yielded conflicting findings. This study aims to explore impact of proprioceptive training on functional performance after TKA.
Methods
Eighty patients who underwent unilateral TKA were randomly assigned to a proprioceptive exercise (PE) group or a routine exercises (RE) group. The PE group received proprioceptive exercises in addition to routine physiotherapy. Osteoarthritis Research Society Internal (OARSI) recommended tests and Oxford Knee Score (OKS) were used to assess performance and outcome at 3 and 6 months.
Results
In the 30-s chair sits test, the PE group outperformed the RE group at 3 months (13.69 vs. 9.17) and 6 months (21.07 vs. 18.63) (p < 0.001 and p = 0.030). Stair climbing favoured PE group at 3 months (8.86 vs. 16.66, p = 0.037) and 6 months (0.556 vs. 1.133, p = 0.001). At 6 months in the 40-m fast-paced walk test, the PE group had a significantly shorter time (0.308 min vs. 0.557 min, p < 0.001). Timed up and go test at 6 months favoured PE group (0.204 min vs. 0.377 min). In the 6-min walk test, the PE group covered significantly greater distances than the RE group at 3 months (589.59 vs. 346.53 m, p < 0.001) and 6 months (649.60 vs. 448.32 m, p < 0.001). OKS at 3 months was 38 ± 2.0 for PE group and 38 ± 4 for RE group (p = 1). OKS at 6 months was 42 ± 4 for PE group and 40 ± 2 for RE group (p = 0.94).
Conclusion
This study highlights the importance of proprioception-based rehabilitation in improving functional performance for TKA patients, surpassing traditional rehabilitation programmes.
{"title":"Does Proprioception-Based Rehabilitation Enhance Functional Outcome in Total Knee Arthroplasty? A Prospective Randomised Study","authors":"Yuvarajan Palanisamy, Arjun R. Prasad, Karthik Seetharaman, K. Ganesan, M. Kavitha, David V. Rajan","doi":"10.1007/s43465-024-01218-z","DOIUrl":"https://doi.org/10.1007/s43465-024-01218-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Rehabilitation after Total Knee Arthroplasty (TKA) often includes proprioceptive exercises to prevent falls, but studies on proprioceptive training have yielded conflicting findings. This study aims to explore impact of proprioceptive training on functional performance after TKA.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Eighty patients who underwent unilateral TKA were randomly assigned to a proprioceptive exercise (PE) group or a routine exercises (RE) group. The PE group received proprioceptive exercises in addition to routine physiotherapy. Osteoarthritis Research Society Internal (OARSI) recommended tests and Oxford Knee Score (OKS) were used to assess performance and outcome at 3 and 6 months.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>In the 30-s chair sits test, the PE group outperformed the RE group at 3 months (13.69 vs. 9.17) and 6 months (21.07 vs. 18.63) (<i>p</i> < 0.001 and <i>p</i> = 0.030). Stair climbing favoured PE group at 3 months (8.86 vs. 16.66, <i>p</i> = 0.037) and 6 months (0.556 vs. 1.133, p = 0.001). At 6 months in the 40-m fast-paced walk test, the PE group had a significantly shorter time (0.308 min vs. 0.557 min, <i>p</i> < 0.001). Timed up and go test at 6 months favoured PE group (0.204 min vs. 0.377 min). In the 6-min walk test, the PE group covered significantly greater distances than the RE group at 3 months (589.59 vs. 346.53 m, <i>p</i> < 0.001) and 6 months (649.60 vs. 448.32 m, <i>p</i> < 0.001). OKS at 3 months was 38 ± 2.0 for PE group and 38 ± 4 for RE group (<i>p</i> = 1). OKS at 6 months was 42 ± 4 for PE group and 40 ± 2 for RE group (<i>p</i> = 0.94).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This study highlights the importance of proprioception-based rehabilitation in improving functional performance for TKA patients, surpassing traditional rehabilitation programmes.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"53 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141934720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.1007/s43465-024-01222-3
İdris Çoban, Mustafa Karakaplan, Emre Ergen, Okan Aslantürk, Muhammed Köroğlu, Kadir Ertem
Background
Humeral lateral condyle fracture is the most common elbow fracture in children after supracondylar fractures. Non-union of these fractures may cause ulnar nerve deficit, deformity and loss of joint motion, which are difficult to manage. Treatment of lateral condyle non-union can be done in two stages or one stage. However, despite all types of treatment, the chance of success is very variable. Many complications such as avascular necrosis, loss of motion, non-union, chronic pain, and heterotopic ossification have been reported as a result of surgeries performed for lateral condyle pseudoarthrosis.
Objective
In this article, we applied two-stage surgical treatment to a pediatric patient who developed ulnar neuropathy and elbow valgus deformity as a result of lateral condyle non-union.
Case report
A 8-year-old boy with lateral condyle nonunion presented to our clinic with pain and deformity. After initial examination, two-stage surgical treatment was planned to achieve union and deformity correction. In the first stage, we performed pseudoarthrosis surgery and ulnar nerve anterior transposition, and in the second stage, we performed elbow valgus deformity correction surgery. In three year follow-up, the range of elbow was 130/5/0 flexion/extension, with full supnation and pronation. Carrying angle was same with the opposite side.
Conclusion
Pediatric humeral lateral condyle nonunions cause deformity, pain, loss of motion, instability and neuropathy. Surgical treatment of nonunions with a careful planning provide excellent clinical and functional results.
{"title":"Successful Management of a Pediatric Patient with Humeral Lateral Condyle Non-union, Elbow Valgus Deformity and Ulnar Neuropathy","authors":"İdris Çoban, Mustafa Karakaplan, Emre Ergen, Okan Aslantürk, Muhammed Köroğlu, Kadir Ertem","doi":"10.1007/s43465-024-01222-3","DOIUrl":"https://doi.org/10.1007/s43465-024-01222-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Humeral lateral condyle fracture is the most common elbow fracture in children after supracondylar fractures. Non-union of these fractures may cause ulnar nerve deficit, deformity and loss of joint motion, which are difficult to manage. Treatment of lateral condyle non-union can be done in two stages or one stage. However, despite all types of treatment, the chance of success is very variable. Many complications such as avascular necrosis, loss of motion, non-union, chronic pain, and heterotopic ossification have been reported as a result of surgeries performed for lateral condyle pseudoarthrosis.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>In this article, we applied two-stage surgical treatment to a pediatric patient who developed ulnar neuropathy and elbow valgus deformity as a result of lateral condyle non-union.</p><h3 data-test=\"abstract-sub-heading\">Case report</h3><p>A 8-year-old boy with lateral condyle nonunion presented to our clinic with pain and deformity. After initial examination, two-stage surgical treatment was planned to achieve union and deformity correction. In the first stage, we performed pseudoarthrosis surgery and ulnar nerve anterior transposition, and in the second stage, we performed elbow valgus deformity correction surgery. In three year follow-up, the range of elbow was 130/5/0 flexion/extension, with full supnation and pronation. Carrying angle was same with the opposite side.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Pediatric humeral lateral condyle nonunions cause deformity, pain, loss of motion, instability and neuropathy. Surgical treatment of nonunions with a careful planning provide excellent clinical and functional results.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"34 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141739172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-19DOI: 10.1007/s43465-024-01224-1
Raju Vaishya, Mohit Kumar Patralekh, Abhishek Vaish, Luke V. Tollefson, Robert F. LaPrade
Background and Aims
Multi-ligament knee injuries (MLKI) are serious and challenging to manage. This study aimed to elucidate the impact of surgical timing on both early and long-term outcomes following an MLKI.
Methods
A comprehensive search strategy was employed across PubMed, Scopus, Web of Science, and the Cochrane Library. Studies were identified using a combination of relevant keywords encompassing “multi-ligament knee injury,” “knee dislocation,” “reconstruction,” “repair,” “surgery,” and “timing,” and their synonyms, along with appropriate Boolean operators. Selection of articles (systematic reviews and meta-analyses) adhered to predefined inclusion and exclusion criteria. Furthermore, a meta-analysis was conducted utilizing data extracted from primary studies.
Results
Early surgery for MLKI demonstrated a significant advantage over delayed surgery, reflected by significantly higher Lysholm scores (Mean Difference [MD] 3.51; 95% Confidence Interval [CI] 1.79, 5.22), IKDC objective scores (Mantel–Haenszel Odds Ratio [MH-OR] 2.95; 95% CI 1.30, 6.69), Tegner activity scores (MD 0.38; 95% CI 0.08, 0.69), and Mayer’s ratings (MH-OR 5.47; 95% CI 1.27, 23.56). In addition, we found a significantly reduced risk of secondary chondral lesions (MH-OR 0.33; 95% CI 0.23, 0.48), lower instrumented anterior tibial translation in the early surgery group (MD −0.92; 95% CI −1.83, −0.01), but no significant difference was observed in the secondary meniscal tears, between the two groups. However, the early surgery group also exhibited a significantly increased risk of knee stiffness (MH-OR 2.47; 95% CI 1.22, 5.01) and a greater likelihood of requiring manipulation under anaesthesia (MH-OR 3.91; 95% CI 1.10, 13.87).
Conclusion
Early surgery for MLKI improves function, and stability, and reduces further articular cartilage damage, but increases the risk of stiffness.
Level of Evidence
IV.
背景和目的膝关节多韧带损伤(MLKI)是一种严重的、具有挑战性的损伤。本研究旨在阐明手术时机对多韧带膝关节损伤早期和长期预后的影响。方法在 PubMed、Scopus、Web of Science 和 Cochrane Library 中采用了综合搜索策略。采用包含 "多韧带膝关节损伤"、"膝关节脱位"、"重建"、"修复"、"手术 "和 "时机 "及其同义词的相关关键词组合,并使用适当的布尔运算符来确定研究。文章(系统综述和荟萃分析)的选择遵循预定义的纳入和排除标准。此外,还利用从主要研究中提取的数据进行了一项荟萃分析。结果MLKI的早期手术比延迟手术具有显著优势,这体现在Lysholm评分明显更高(平均差 [MD] 3.51; 95% Confidence Interval [CI] 1.79, 5.22)、IKDC 客观评分(Mantel-Haenszel Odds Ratio [MH-OR] 2.95; 95% CI 1.30, 6.69)、Tegner 活动评分(MD 0.38; 95% CI 0.08, 0.69)和 Mayer 评分(MH-OR 5.47; 95% CI 1.27, 23.56)。此外,我们还发现,早期手术组发生继发性软骨损伤的风险明显降低(MH-OR 0.33;95% CI 0.23,0.48),胫骨前方器械移位较低(MD -0.92;95% CI -1.83,-0.01),但两组在继发性半月板撕裂方面无明显差异。然而,早期手术组膝关节僵硬的风险也明显增加(MH-OR 2.47; 95% CI 1.22, 5.01),需要在麻醉下进行操作的可能性也更大(MH-OR 3.91; 95% CI 1.10, 13.87)。
{"title":"Effect of Timing of Surgery on the Outcomes and Complications in Multi-ligament Knee Injuries: An Overview of Systematic Reviews and A Meta-analysis","authors":"Raju Vaishya, Mohit Kumar Patralekh, Abhishek Vaish, Luke V. Tollefson, Robert F. LaPrade","doi":"10.1007/s43465-024-01224-1","DOIUrl":"https://doi.org/10.1007/s43465-024-01224-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background and Aims</h3><p>Multi-ligament knee injuries (MLKI) are serious and challenging to manage. This study aimed to elucidate the impact of surgical timing on both early and long-term outcomes following an MLKI.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A comprehensive search strategy was employed across PubMed, Scopus, Web of Science, and the Cochrane Library. Studies were identified using a combination of relevant keywords encompassing “multi-ligament knee injury,” “knee dislocation,” “reconstruction,” “repair,” “surgery,” and “timing,” and their synonyms, along with appropriate Boolean operators. Selection of articles (systematic reviews and meta-analyses) adhered to predefined inclusion and exclusion criteria. Furthermore, a meta-analysis was conducted utilizing data extracted from primary studies.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Early surgery for MLKI demonstrated a significant advantage over delayed surgery, reflected by significantly higher Lysholm scores (Mean Difference [MD] 3.51; 95% Confidence Interval [CI] 1.79, 5.22), IKDC objective scores (Mantel–Haenszel Odds Ratio [MH-OR] 2.95; 95% CI 1.30, 6.69), Tegner activity scores (MD 0.38; 95% CI 0.08, 0.69), and Mayer’s ratings (MH-OR 5.47; 95% CI 1.27, 23.56). In addition, we found a significantly reduced risk of secondary chondral lesions (MH-OR 0.33; 95% CI 0.23, 0.48), lower instrumented anterior tibial translation in the early surgery group (MD −0.92; 95% CI −1.83, −0.01), but no significant difference was observed in the secondary meniscal tears, between the two groups. However, the early surgery group also exhibited a significantly increased risk of knee stiffness (MH-OR 2.47; 95% CI 1.22, 5.01) and a greater likelihood of requiring manipulation under anaesthesia (MH-OR 3.91; 95% CI 1.10, 13.87).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Early surgery for MLKI improves function, and stability, and reduces further articular cartilage damage, but increases the risk of stiffness.</p><h3 data-test=\"abstract-sub-heading\">Level of Evidence</h3><p>IV.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"45 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141739171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study aimed to assess Sirt6 levels in serum of knee osteoarthritis (OA) patients compared to healthy individuals to evaluate its correlation with OA and to understand how Sirt6 is linked with the change in IL-6 levels.
Methods
The cross-sectional study involved 50 knee OA patients clinically diagnosed as per the American College of Rheumatology guidelines and 50 healthy controls. Radiological examination as per Kellgren–Lawrence (KL) criteria was done to determine the disease severity. Peripheral blood samples were collected from each participant, and serum Sirt6 and IL-6 levels were measured using ELISA.
Results
The serum Sirt6 levels in knee OA patients were significantly lower as compared to healthy controls (p = 0.023). Patients with knee OA of KL grade 4 had significantly lower Sirt6 levels as compared to those with KL grade 2 OA (p = 0.031). Individuals of younger age group had higher Sirt6 levels compared to older age group. IL-6 levels in knee OA patients were significantly higher as compared to controls (p = 0.007). A negative correlation was observed between serum Sirt6 and IL-6 levels (r = − 0.407; p = 0.035).
Conclusion
The study concludes that serum Sirt6 levels are inversely associated with knee OA and may serve as a potential biomarker for the disease. Moreover, a negative correlation between Sirt6 and IL-6 levels was observed in this study. Further investigations are necessary to confirm these findings and to explore the mechanisms by which Sirt6 and IL-6 are involved in OA.
该研究旨在评估膝关节骨性关节炎(OA)患者血清中的 Sirt6 水平,并与健康人进行比较,以评估其与 OA 的相关性,同时了解 Sirt6 与 IL-6 水平变化之间的关系。方法该横断面研究涉及 50 名根据美国风湿病学会指南临床诊断的膝关节 OA 患者和 50 名健康对照组。根据凯尔格伦-劳伦斯(Kellgren-Lawrence,KL)标准进行放射学检查,以确定疾病的严重程度。结果与健康对照组相比,膝关节 OA 患者的血清 Sirt6 水平明显较低(p = 0.023)。与 KL 2 级膝关节 OA 患者相比,KL 4 级膝关节 OA 患者的 Sirt6 水平明显较低(p = 0.031)。与年龄较大的人相比,年龄较小的人 Sirt6 水平较高。与对照组相比,膝关节 OA 患者的 IL-6 水平明显更高(p = 0.007)。结论该研究得出结论,血清 Sirt6 水平与膝关节 OA 成反比,可作为该疾病的潜在生物标志物。此外,本研究还观察到 Sirt6 与 IL-6 水平呈负相关。要证实这些发现并探索 Sirt6 和 IL-6 参与 OA 的机制,还需要进一步的研究。
{"title":"Serum Sirt6 as a Potential Biomarker for Osteoarthritis and its Correlation with IL-6 Alterations","authors":"Nikhil Gupta, Anchal Arora, Navjot Kanwar, Kavin Khatri, Abhinav Kanwal","doi":"10.1007/s43465-024-01223-2","DOIUrl":"https://doi.org/10.1007/s43465-024-01223-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>The study aimed to assess Sirt6 levels in serum of knee osteoarthritis (OA) patients compared to healthy individuals to evaluate its correlation with OA and to understand how Sirt6 is linked with the change in IL-6 levels.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The cross-sectional study involved 50 knee OA patients clinically diagnosed as per the American College of Rheumatology guidelines and 50 healthy controls. Radiological examination as per Kellgren–Lawrence (KL) criteria was done to determine the disease severity. Peripheral blood samples were collected from each participant, and serum Sirt6 and IL-6 levels were measured using ELISA.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The serum Sirt6 levels in knee OA patients were significantly lower as compared to healthy controls (p = 0.023). Patients with knee OA of KL grade 4 had significantly lower Sirt6 levels as compared to those with KL grade 2 OA (p = 0.031). Individuals of younger age group had higher Sirt6 levels compared to older age group. IL-6 levels in knee OA patients were significantly higher as compared to controls (p = 0.007). A negative correlation was observed between serum Sirt6 and IL-6 levels (r = − 0.407; p = 0.035).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The study concludes that serum Sirt6 levels are inversely associated with knee OA and may serve as a potential biomarker for the disease. Moreover, a negative correlation between Sirt6 and IL-6 levels was observed in this study. Further investigations are necessary to confirm these findings and to explore the mechanisms by which Sirt6 and IL-6 are involved in OA.</p>","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"253 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141739284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.1007/s43465-024-01221-4
Madhan Jeyaraman, Sathish Muthu, S. S. Amarnath
{"title":"Barriers and Solutions Towards Integrating Orthobiologics into Clinical Orthopaedic Practice","authors":"Madhan Jeyaraman, Sathish Muthu, S. S. Amarnath","doi":"10.1007/s43465-024-01221-4","DOIUrl":"https://doi.org/10.1007/s43465-024-01221-4","url":null,"abstract":"","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"28 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141611811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11DOI: 10.1007/s43465-024-01217-0
David Figueroa, María Loreto Figueroa, Martin Cañas, Alexandra Feuereisen, Francisco Figueroa
<h3 data-test="abstract-sub-heading">Introduction</h3><p>Multi-ligament knee injuries (MLKIs) are rare and complex knee lesions and are potentially associated with intra-articular injuries, especially meniscal tears. Understanding the meniscal tear patterns involved in MLKI can help the orthopedic surgeon treat these complex injuries.</p><h3 data-test="abstract-sub-heading">Objective</h3><p>The purpose of this study was to describe the incidence, classification, and treatment of meniscal injuries in a cohort of patients with MLKIs and carry out an updated review of the evidence available.</p><h3 data-test="abstract-sub-heading">Materials and methods</h3><p>Descriptive retrospective study. Patients with a history of reconstructive surgery for MLKI performed between 2013 and 2023 were included. Informed consent was obtained from all patients included in the study. Patient demographics, magnetic resonance imaging (MRI) study, and operative reports were reviewed. Groups were then formed based on ligament injury patterns. Meniscal tears were identified by MRI and through diagnostic arthroscopy for each patient. The association between meniscal lesions and injury patterns was calculated through Fisher’s exact test. Agreement between the presence of meniscal tear on MRI and in diagnostic arthroscopy was measured using the kappa test. The sensitivity and specificity of MRI were calculated. We inferred the presence of a meniscal tear by injury pattern using the Agresti-Coull confidence interval. For the statistical analysis, a significance of 5% and a confidence interval of 95% were considered.</p><h3 data-test="abstract-sub-heading">Results</h3><p>Seventy patients with MLKIs were included, with a mean age of 30.69 years (SD 10.65). Forty-seven patients had meniscal lesions (67.1%). Of them, 6 had only medial meniscus tears, 31 had only lateral meniscus tears, and 10 had lesions of both menisci, comprising 57 meniscal lesions in total. An anterior cruciate ligament (ACL) + medial collateral ligament/posteromedial corner (MCL/PMC) was the most common injury pattern (52.86% of all patients). Of these 37 patients, 78.38% had meniscal injuries, and most of them (68.97%) were only lateral meniscus injuries. The odds ratio (OR) of having a meniscal tear when having an ACL + medial-side injury was 4.83 (95% CI; 0.89–26.17). Patients with ACL + lateral-side injury pattern had meniscal tears in 42.86%. The lateral meniscus was involved in 100% of these patients. 62.5% of medial meniscus injuries were treated by meniscal repair, and 37.5% by partial meniscectomy. 58.54% of lateral meniscus injuries were treated by meniscal repair, and 39.02% by partial meniscectomy. Agreement calculated using the kappa test between MRI and diagnostic arthroscopy for medial meniscal lesions was 78.57%, and for lateral meniscal lesions was 84.29%.</p><h3 data-test="abstract-sub-heading">Conclusion</h3><p>The ligament injury pattern and the side of the injured collateral ligament infl
{"title":"Meniscal Lesions in Multi-Ligament Knee Injuries","authors":"David Figueroa, María Loreto Figueroa, Martin Cañas, Alexandra Feuereisen, Francisco Figueroa","doi":"10.1007/s43465-024-01217-0","DOIUrl":"https://doi.org/10.1007/s43465-024-01217-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Multi-ligament knee injuries (MLKIs) are rare and complex knee lesions and are potentially associated with intra-articular injuries, especially meniscal tears. Understanding the meniscal tear patterns involved in MLKI can help the orthopedic surgeon treat these complex injuries.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>The purpose of this study was to describe the incidence, classification, and treatment of meniscal injuries in a cohort of patients with MLKIs and carry out an updated review of the evidence available.</p><h3 data-test=\"abstract-sub-heading\">Materials and methods</h3><p>Descriptive retrospective study. Patients with a history of reconstructive surgery for MLKI performed between 2013 and 2023 were included. Informed consent was obtained from all patients included in the study. Patient demographics, magnetic resonance imaging (MRI) study, and operative reports were reviewed. Groups were then formed based on ligament injury patterns. Meniscal tears were identified by MRI and through diagnostic arthroscopy for each patient. The association between meniscal lesions and injury patterns was calculated through Fisher’s exact test. Agreement between the presence of meniscal tear on MRI and in diagnostic arthroscopy was measured using the kappa test. The sensitivity and specificity of MRI were calculated. We inferred the presence of a meniscal tear by injury pattern using the Agresti-Coull confidence interval. For the statistical analysis, a significance of 5% and a confidence interval of 95% were considered.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Seventy patients with MLKIs were included, with a mean age of 30.69 years (SD 10.65). Forty-seven patients had meniscal lesions (67.1%). Of them, 6 had only medial meniscus tears, 31 had only lateral meniscus tears, and 10 had lesions of both menisci, comprising 57 meniscal lesions in total. An anterior cruciate ligament (ACL) + medial collateral ligament/posteromedial corner (MCL/PMC) was the most common injury pattern (52.86% of all patients). Of these 37 patients, 78.38% had meniscal injuries, and most of them (68.97%) were only lateral meniscus injuries. The odds ratio (OR) of having a meniscal tear when having an ACL + medial-side injury was 4.83 (95% CI; 0.89–26.17). Patients with ACL + lateral-side injury pattern had meniscal tears in 42.86%. The lateral meniscus was involved in 100% of these patients. 62.5% of medial meniscus injuries were treated by meniscal repair, and 37.5% by partial meniscectomy. 58.54% of lateral meniscus injuries were treated by meniscal repair, and 39.02% by partial meniscectomy. Agreement calculated using the kappa test between MRI and diagnostic arthroscopy for medial meniscal lesions was 78.57%, and for lateral meniscal lesions was 84.29%.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The ligament injury pattern and the side of the injured collateral ligament infl","PeriodicalId":13338,"journal":{"name":"Indian Journal of Orthopaedics","volume":"13 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141611808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}