Pub Date : 2024-05-15DOI: 10.18231/j.ijmr.2024.007
Anuradha Sood, Ankita Sharma, Narender Kumar
: Hepatitis-A virus and Hepatitis-E virus are spread enterically, resulting in acute viral hepatitis (AVH) in developing countries. Fecal-oral transmitted hepatitis cause major health problems in our country. The aim of present study is to determine the seroprevalence of HAV and HEV in AVH patients attending the tertiary care hospital at Dr. Rajendra Prasad Govt. Medical College Kangra at Tanda, Himachal Pradesh (DRPGMC). Insufficient data makes it difficult to determine an accurate prevalence of illness in this region of India.: The Viral Research and Diagnostic Laboratory (VRDL), in the Department of Microbiology at DRPGMC Tanda, Himachal Pradesh, consolidated retrospective data of 2-years duration. The study population included 784 serum samples received from outdoor and indoor patients were considered in the study.: Of the 784 serum samples that were chosen for our study, HAV and HEV reactive patients showed a seroprevalence of 11.20% and 1.80% respectively. During two years of the study, the co-infection rate of HAV and HEV in patients with acute viral hepatitis was 0.5%. Compared to females (31.80% and 42%), males reported higher seroprevalence of HAV (68.10%) and HEV (57.10%). Further data shows that HAV infection was observed in all age groups and the highest prevalence was reported in the age range from 11 to 20 years. The HEV infection was not observed in the pediatric age groups, it was only observed in adults. Maximum prevalence of HEV was reported in the age group of 21-30 years. The highest number of reactive cases was recorded in the month of August and September.: We found that the prevalence of HAV is significantly higher than that of HEV during two years of study period. In this study, we observed that HAV is more predominant in males as compare to females.HEV infections were only observed in adults.
:甲型肝炎病毒和戊型肝炎病毒通过肠道传播，在发展中国家导致急性病毒性肝炎（AVH）。粪口传播肝炎在我国造成了严重的健康问题。本研究旨在确定在喜马偕尔邦坦达的拉金德拉-普拉萨德博士政府医学院康拉分院（DRPGMC）三级护理医院就诊的 AVH 患者中 HAV 和 HEV 的血清流行率。由于数据不足，很难确定印度这一地区的准确发病率。 喜马偕尔邦坦达 DRPGMC 微生物学系的病毒研究与诊断实验室（VRDL）整合了为期两年的回顾性数据。研究对象包括从室外和室内患者处采集的 784 份血清样本：在我们选取的 784 份血清样本中，HAV 和 HEV 反应患者的血清阳性率分别为 11.20% 和 1.80%。在两年的研究中，急性病毒性肝炎患者的 HAV 和 HEV 合并感染率为 0.5%。与女性（31.80% 和 42%）相比，男性的 HAV（68.10%）和 HEV（57.10%）血清阳性率更高。进一步的数据显示，所有年龄组均可观察到 HAV 感染，11 至 20 岁年龄组的感染率最高。在儿科年龄组中未发现 HEV 感染，仅在成人中发现。21-30 岁年龄组的 HEV 感染率最高。8月和9月的反应性病例数最多：我们发现，在两年的研究期间，HAV 的流行率明显高于 HEV。在这项研究中，我们发现与女性相比，男性更容易感染 HAV。
{"title":"Seroprevalence of Hepatitis A virus and Hepatitis E virus in patients presenting with acute viral hepatitis: A retrospective study of 2-years at tertiary care Hospital, Himachal Pradesh in Northern India","authors":"Anuradha Sood, Ankita Sharma, Narender Kumar","doi":"10.18231/j.ijmr.2024.007","DOIUrl":"https://doi.org/10.18231/j.ijmr.2024.007","url":null,"abstract":": Hepatitis-A virus and Hepatitis-E virus are spread enterically, resulting in acute viral hepatitis (AVH) in developing countries. Fecal-oral transmitted hepatitis cause major health problems in our country. The aim of present study is to determine the seroprevalence of HAV and HEV in AVH patients attending the tertiary care hospital at Dr. Rajendra Prasad Govt. Medical College Kangra at Tanda, Himachal Pradesh (DRPGMC). Insufficient data makes it difficult to determine an accurate prevalence of illness in this region of India.: The Viral Research and Diagnostic Laboratory (VRDL), in the Department of Microbiology at DRPGMC Tanda, Himachal Pradesh, consolidated retrospective data of 2-years duration. The study population included 784 serum samples received from outdoor and indoor patients were considered in the study.: Of the 784 serum samples that were chosen for our study, HAV and HEV reactive patients showed a seroprevalence of 11.20% and 1.80% respectively. During two years of the study, the co-infection rate of HAV and HEV in patients with acute viral hepatitis was 0.5%. Compared to females (31.80% and 42%), males reported higher seroprevalence of HAV (68.10%) and HEV (57.10%). Further data shows that HAV infection was observed in all age groups and the highest prevalence was reported in the age range from 11 to 20 years. The HEV infection was not observed in the pediatric age groups, it was only observed in adults. Maximum prevalence of HEV was reported in the age group of 21-30 years. The highest number of reactive cases was recorded in the month of August and September.: We found that the prevalence of HAV is significantly higher than that of HEV during two years of study period. In this study, we observed that HAV is more predominant in males as compare to females.HEV infections were only observed in adults.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-15DOI: 10.18231/j.ijmr.2024.006
D. Taraphdar, R. Hawaldar, S. Sodani
Rickettsial infections are under-reported in India. The actual disease burden has been underestimated as non-specific serological tests are mostly used to diagnose these infections. The aim of this study was the detection of Rickettsia infections in clinical specimens by Real-time Polymerase Chain Reaction.A study was established to analyse blood samples taken from pyrexia of unknown origin (PUO) or undifferentiated fever cases. A total of 69 such patients, were referred/walked-in to our diagnostic centre, Indore, India between October 2021 and May 2023. The blood samples were collected in EDTA lavender (purple) top tube.Of the tested samples, 14 patients (20.3%) were positive for Rickettsia infection.Gender wise distribution revealed higher incidence (57%) of Rickettsial infections in male patients. Children were majorly infected (50% of cases); multiple infection was also noted in them, though severity was not high. Severe clinical manifestation including hospitalization was also noted in some patients. Few reports are available from India on molecular diagnosis of Rickettsia infection. Early-stage molecular diagnosis will help to stave off and prevent serious complications.
{"title":"A prospective study on Rickettsia infections in Central India","authors":"D. Taraphdar, R. Hawaldar, S. Sodani","doi":"10.18231/j.ijmr.2024.006","DOIUrl":"https://doi.org/10.18231/j.ijmr.2024.006","url":null,"abstract":"Rickettsial infections are under-reported in India. The actual disease burden has been underestimated as non-specific serological tests are mostly used to diagnose these infections. The aim of this study was the detection of Rickettsia infections in clinical specimens by Real-time Polymerase Chain Reaction.A study was established to analyse blood samples taken from pyrexia of unknown origin (PUO) or undifferentiated fever cases. A total of 69 such patients, were referred/walked-in to our diagnostic centre, Indore, India between October 2021 and May 2023. The blood samples were collected in EDTA lavender (purple) top tube.Of the tested samples, 14 patients (20.3%) were positive for Rickettsia infection.Gender wise distribution revealed higher incidence (57%) of Rickettsial infections in male patients. Children were majorly infected (50% of cases); multiple infection was also noted in them, though severity was not high. Severe clinical manifestation including hospitalization was also noted in some patients. Few reports are available from India on molecular diagnosis of Rickettsia infection. Early-stage molecular diagnosis will help to stave off and prevent serious complications. ","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.18231/j.ijmr.2023.027
Srujana Prabhala, Tanuja Javadekar, Ashutosh Pal
Dermatophytosis is the most common type of cutaneous fungal infection seen in man infecting the superficial keratinized layer of the skin, hair and nails. The aim of the study is to isolate and identify the dermatophytes from clinically suspected cases of dermatophytosis, to determine the frequency of occurrence of various species of dermatophytes, to know the prevalence of age and sex of dermatophytosis in the locality. : The present study was carried out in the Department of Microbiology, Medical College and SSG Hospital, Vadodara. A total of 150 clinically diagnosed cases of dermatophytosis were taken for this study. Skin, hair and nail samples were aseptically collected and were subjected to KOH mount examination and culture. Differentiation of the dermatophyte species was performed based on the macroscopic and microscopic examination of culture and physiological test including urease test. : Tinea corporis (41.3%) was the commonest clinical type with a male to female ratio of 1.05:1. Out of these samples, dermatophytes were isolated in 108 cases with the overall isolation rate of 72%. Seven species of dermatophytes were isolated. 53 (49.1%) was the commonest species followed by 22(20.4%). : Identifying dermatophyte species and knowledge of their host preference and ecology play an important role in treating the patient. Correct and efficient laboratory methods for diagnosis of dermatophytosis is the need of the hour to provide correct and timely treatment and prevent the further spread and chronicity of the disease.
{"title":"Clinicomycological profile of dermatophytosis in a tertiary care teaching hospital, Vadodara","authors":"Srujana Prabhala, Tanuja Javadekar, Ashutosh Pal","doi":"10.18231/j.ijmr.2023.027","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.027","url":null,"abstract":"Dermatophytosis is the most common type of cutaneous fungal infection seen in man infecting the superficial keratinized layer of the skin, hair and nails. The aim of the study is to isolate and identify the dermatophytes from clinically suspected cases of dermatophytosis, to determine the frequency of occurrence of various species of dermatophytes, to know the prevalence of age and sex of dermatophytosis in the locality. : The present study was carried out in the Department of Microbiology, Medical College and SSG Hospital, Vadodara. A total of 150 clinically diagnosed cases of dermatophytosis were taken for this study. Skin, hair and nail samples were aseptically collected and were subjected to KOH mount examination and culture. Differentiation of the dermatophyte species was performed based on the macroscopic and microscopic examination of culture and physiological test including urease test. : Tinea corporis (41.3%) was the commonest clinical type with a male to female ratio of 1.05:1. Out of these samples, dermatophytes were isolated in 108 cases with the overall isolation rate of 72%. Seven species of dermatophytes were isolated. 53 (49.1%) was the commonest species followed by 22(20.4%). : Identifying dermatophyte species and knowledge of their host preference and ecology play an important role in treating the patient. Correct and efficient laboratory methods for diagnosis of dermatophytosis is the need of the hour to provide correct and timely treatment and prevent the further spread and chronicity of the disease.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.18231/j.ijmr.2023.022
Maneesh Kumar, Roshan Kamal Topno, Ratnesh Kumar
Noncoding RNAs, known as miRNAs, regulate gene expression. Most miRNAs are converted from DNA sequences into primary miRNAs, processed into precursors, and matured. Survival or virulence of species is targeted by RNAi antifungal treatment. Silencing these genes can reduce fungal proliferation and pathogenicity, thereby improving therapy. RNAi can be used to treat ; however, most research has been conducted in controlled laboratory or animal studies. The immune system neutralizes spores, so not everyone gets sick. Aspergillosis can range from moderate allergic reactions to invasive, life-threatening disease. MiRNAs have been studied in numerous diseases, but their role in immune responses to pulmonary and systemic fungal infections is still being discovered. During disease progression, fungal pathogens can alter signaling and expression of miRNAs in the genetic network. Future investigations on the biological purpose of miRNAs, previously assumed to be a consequence of miRNA synthesis, will illuminate the regulatory function of the miRNA network in plant innate immunity. MiRNAs and their intended targets present opportunities for novel pathogen-fighting strategies and technologies.
{"title":"RNAi: antifungal therapy against Invasive pulmonary aspergillosis (IPA) in humans","authors":"Maneesh Kumar, Roshan Kamal Topno, Ratnesh Kumar","doi":"10.18231/j.ijmr.2023.022","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.022","url":null,"abstract":"Noncoding RNAs, known as miRNAs, regulate gene expression. Most miRNAs are converted from DNA sequences into primary miRNAs, processed into precursors, and matured. Survival or virulence of species is targeted by RNAi antifungal treatment. Silencing these genes can reduce fungal proliferation and pathogenicity, thereby improving therapy. RNAi can be used to treat ; however, most research has been conducted in controlled laboratory or animal studies. The immune system neutralizes spores, so not everyone gets sick. Aspergillosis can range from moderate allergic reactions to invasive, life-threatening disease. MiRNAs have been studied in numerous diseases, but their role in immune responses to pulmonary and systemic fungal infections is still being discovered. During disease progression, fungal pathogens can alter signaling and expression of miRNAs in the genetic network. Future investigations on the biological purpose of miRNAs, previously assumed to be a consequence of miRNA synthesis, will illuminate the regulatory function of the miRNA network in plant innate immunity. MiRNAs and their intended targets present opportunities for novel pathogen-fighting strategies and technologies.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sewage treatment aims to remove the contaminants from different municipal sources in order to prevent pollution of aquatic bodies. There are numerous sewage treatment systems available in the market, including ASP (Activated Sludge Process), MBBR (Moving Bed Bioreactor), MBR (Membrane Bioreactor), etc. One of them, the SBR (Sequential Batch Reactor), is a remarkable technology that may be used in large-scale treatment plants due to its simple maintenance. Sequential batch reactors (SBR) are reactors or basins in which the biological treatment of waste water is carried out in a series of four steps, namely filling, aeration, settling (clarification) and decanting. One of the newest solutions for treating municipal sewage is the sequential batch reactor (SBR). In this research designing study, a thorough design computation for a sewage treatment system with a 100 KLD capacity was elucidated. In this study, two important aspects of design calculation such as units available in the SBR scheme and Equipment’s available in the SBR scheme. Thus, the simple calculation makes it easier for any design engineers to construct their sewage treatment plant or system.
{"title":"STP design calculation for 100 KLD SBR (Sequential batch reactor)","authors":"Ranadive Ananth Govindaraju, Gayathri Parivallal, Sumitha Devarajan","doi":"10.18231/j.ijmr.2023.024","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.024","url":null,"abstract":"Sewage treatment aims to remove the contaminants from different municipal sources in order to prevent pollution of aquatic bodies. There are numerous sewage treatment systems available in the market, including ASP (Activated Sludge Process), MBBR (Moving Bed Bioreactor), MBR (Membrane Bioreactor), etc. One of them, the SBR (Sequential Batch Reactor), is a remarkable technology that may be used in large-scale treatment plants due to its simple maintenance. Sequential batch reactors (SBR) are reactors or basins in which the biological treatment of waste water is carried out in a series of four steps, namely filling, aeration, settling (clarification) and decanting. One of the newest solutions for treating municipal sewage is the sequential batch reactor (SBR). In this research designing study, a thorough design computation for a sewage treatment system with a 100 KLD capacity was elucidated. In this study, two important aspects of design calculation such as units available in the SBR scheme and Equipment’s available in the SBR scheme. Thus, the simple calculation makes it easier for any design engineers to construct their sewage treatment plant or system.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.18231/j.ijmr.2023.030
Yusuf Kagzi, Mustafa Siraj Bohra, Alifiya Kagzi, Umer Rizwan
Citrobacter generally colonizes the gastrointestinal and urogenital tracts of humans, but musculoskeletal infection by Citrobacter in the elderly is extremely rare. To our knowledge, less than 15 cases of causing musculoskeletal infection have been reported in the literature. In the last few years, there has been a considerable increase in the incidence of prosthetic knee joint infection in the United States, with a higher risk of infection in the first two years following surgery. Although gram-positive bacteria like Staphylococcus and Streptococci are more common cause of PJI, gram-negative bacteria can also be found in infected joints. We report the first case of PJI in the left knee due to in an 82-year-old adult two years after bilateral knee arthroplasty. This case report intends to educate and raise awareness for causing PJI as a long term post-op complication even in healthy individuals. We searched articles on Pubmed and Medline for PJI and citrobacter infection. We report clinically and microbiologically confirmed in a synovial fluid sample of the left knee joint. should be considered as a possible pathogen for PJI in long term setting even in an otherwise healthy individual.
{"title":"A rare first case of prosthetic knee joint infection by Citrobacter koseri","authors":"Yusuf Kagzi, Mustafa Siraj Bohra, Alifiya Kagzi, Umer Rizwan","doi":"10.18231/j.ijmr.2023.030","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.030","url":null,"abstract":"Citrobacter generally colonizes the gastrointestinal and urogenital tracts of humans, but musculoskeletal infection by Citrobacter in the elderly is extremely rare. To our knowledge, less than 15 cases of causing musculoskeletal infection have been reported in the literature. In the last few years, there has been a considerable increase in the incidence of prosthetic knee joint infection in the United States, with a higher risk of infection in the first two years following surgery. Although gram-positive bacteria like Staphylococcus and Streptococci are more common cause of PJI, gram-negative bacteria can also be found in infected joints. We report the first case of PJI in the left knee due to in an 82-year-old adult two years after bilateral knee arthroplasty. This case report intends to educate and raise awareness for causing PJI as a long term post-op complication even in healthy individuals. We searched articles on Pubmed and Medline for PJI and citrobacter infection. We report clinically and microbiologically confirmed in a synovial fluid sample of the left knee joint. should be considered as a possible pathogen for PJI in long term setting even in an otherwise healthy individual.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.18231/j.ijmr.2023.029
Aakash Kapoor Pal
Urinary tract infections (UTIs) are prevalent bacterial infections. Gram-negative bacilli are frequently isolated as the causative pathogens in UTIs, and antibiotics are commonly used to treat them. However, the overuse of antibiotics has led to the development of resistance in some uropathogens. : To find the prevalence and antimicrobial susceptibility patterns in clinically significant isolates among urine sample in a tertiary care centre. : Fresh mid-stream urine samples were collected aseptically in sterile containers. The samples were inoculated on 5% sheep blood agar and MacConkey agar. The isolates were identified to the species level using biochemical tests/Vitek 2 compact. : A total of 5847 specimens were examined for significant bacteriuria, out of which 1160 showed bacterial growth in urine cultures. The most commonly isolated pathogens were (57.67%) and (18.63%). The antibiotics aminoglycosides (84%), carbapenems (79%), and nitrofurantoin (63%) displayed a high rate of sensitivity against these pathogens. : Due to the variability of drug sensitivity among bacterial pathogens over time, regular surveillance and monitoring are essential to provide physicians with updated information for the most effective empirical treatment of UTIs.
{"title":"Study of the prevalence and antibiotics susceptibility patterns in clinically significant isolates among urine sample in a tertiary care centre","authors":"Aakash Kapoor Pal","doi":"10.18231/j.ijmr.2023.029","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.029","url":null,"abstract":"Urinary tract infections (UTIs) are prevalent bacterial infections. Gram-negative bacilli are frequently isolated as the causative pathogens in UTIs, and antibiotics are commonly used to treat them. However, the overuse of antibiotics has led to the development of resistance in some uropathogens. : To find the prevalence and antimicrobial susceptibility patterns in clinically significant isolates among urine sample in a tertiary care centre. : Fresh mid-stream urine samples were collected aseptically in sterile containers. The samples were inoculated on 5% sheep blood agar and MacConkey agar. The isolates were identified to the species level using biochemical tests/Vitek 2 compact. : A total of 5847 specimens were examined for significant bacteriuria, out of which 1160 showed bacterial growth in urine cultures. The most commonly isolated pathogens were (57.67%) and (18.63%). The antibiotics aminoglycosides (84%), carbapenems (79%), and nitrofurantoin (63%) displayed a high rate of sensitivity against these pathogens. : Due to the variability of drug sensitivity among bacterial pathogens over time, regular surveillance and monitoring are essential to provide physicians with updated information for the most effective empirical treatment of UTIs.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cardiovascular implantable electronic devices (CIED) improve quality of life of patients with cardiac arrhythmias and also improves chances of survival. CIEDs, however it may cause complications. To avoid these complications surgical prophylaxis in CIED insertion is required to avoid infection. Due to the rise in antimicrobial resistance the use of antimicrobial agents should be rational and under control. To prevent resistance of antibiotics their use and duration of therapy should be monitored. The high-end and restricted antibiotics should be used only if organisms grow in cultures or if suggested by infectious disease specialists. This review focuses on empirical antibiotics used as prophylaxis. The purpose of this document is to outline the antimicrobial options which can be used as an empirical prophylactic agent in CIED infections.
{"title":"Cardiac implantable electronic device infection: Microbiology and antibiotic prophylaxis","authors":"Shraddha Shivling Paralkar, Deepa Godbole, Swapnil Mundhe","doi":"10.18231/j.ijmr.2023.023","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.023","url":null,"abstract":"Cardiovascular implantable electronic devices (CIED) improve quality of life of patients with cardiac arrhythmias and also improves chances of survival. CIEDs, however it may cause complications. To avoid these complications surgical prophylaxis in CIED insertion is required to avoid infection. Due to the rise in antimicrobial resistance the use of antimicrobial agents should be rational and under control. To prevent resistance of antibiotics their use and duration of therapy should be monitored. The high-end and restricted antibiotics should be used only if organisms grow in cultures or if suggested by infectious disease specialists. This review focuses on empirical antibiotics used as prophylaxis. The purpose of this document is to outline the antimicrobial options which can be used as an empirical prophylactic agent in CIED infections.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.18231/j.ijmr.2023.025
Zohmangaiha Chawngthu, Lalnun Tluanga, John Zothanzama, V L Thachunglura, Benjamin Lalbiakmawia, Laltanpuia Renthlei
Identification of fungi to species level is paramount in both basic and applied applications in scientific research. A diverse group of fungi play a crucial role in ecosystem functioning and significantly contribute to the biodiversity of various ecosystems. In the northeastern state of Mizoram, India, the study of wood-inhabiting fungi holds immense potential for uncovering the region's fungal diversity and ecological interactions. The present study investigated the phylogenetic relationships and taxonomic identities of different fungal species of polypores isolated from diverse parts of Mizoram, India. Fungal species were collected and identified using a macro and micro-morphological characteristics and molecular approaches. Nuclear ribosomal DNA sequences, along with the internal transcribed spacers (ITS-1 and ITS-2), and the 5.8S gene area, were used to identified the collected samples. 23 fungal isolates of polypores were selected for molecular phylogenetic analysis. The 23 species were identified to the species level based on the fungal sequences with known identities in GenBank. The combined approach both morphological and molecular techniques proposed in the study holds the potential to address these challenges and provide a more efficient and accurate way of understanding fungal distribution.
{"title":"Wood rotting polyporales from the biodiversity reserves within the Indian subtropical habitat","authors":"Zohmangaiha Chawngthu, Lalnun Tluanga, John Zothanzama, V L Thachunglura, Benjamin Lalbiakmawia, Laltanpuia Renthlei","doi":"10.18231/j.ijmr.2023.025","DOIUrl":"https://doi.org/10.18231/j.ijmr.2023.025","url":null,"abstract":"Identification of fungi to species level is paramount in both basic and applied applications in scientific research. A diverse group of fungi play a crucial role in ecosystem functioning and significantly contribute to the biodiversity of various ecosystems. In the northeastern state of Mizoram, India, the study of wood-inhabiting fungi holds immense potential for uncovering the region's fungal diversity and ecological interactions. The present study investigated the phylogenetic relationships and taxonomic identities of different fungal species of polypores isolated from diverse parts of Mizoram, India. Fungal species were collected and identified using a macro and micro-morphological characteristics and molecular approaches. Nuclear ribosomal DNA sequences, along with the internal transcribed spacers (ITS-1 and ITS-2), and the 5.8S gene area, were used to identified the collected samples. 23 fungal isolates of polypores were selected for molecular phylogenetic analysis. The 23 species were identified to the species level based on the fungal sequences with known identities in GenBank. The combined approach both morphological and molecular techniques proposed in the study holds the potential to address these challenges and provide a more efficient and accurate way of understanding fungal distribution.","PeriodicalId":13428,"journal":{"name":"Indian Journal of Microbiology Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136183867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-15DOI: 10.18231/j.ijmr.2023.028
Varun Bajaj, Mithu Banerjee, Sudhir Dubey, K S Rajmohan, Syed Asif Hashmi, Surabhi Bajaj
Irritable bowel syndrome (IBS) is functional bowel disorder characterized by abdominal pain or discomfort and altered bowel habits in the absence of detectable structural abnormalities. Protozoan cysts are commonly found in the stool samples of patients with IBS and a rising body of evidence suggests a direct causal relationship. Cryptosporidium infection can be a potential candidate for IBS. We studied prevalence, association, and genotype of cryptosporidium at a tertiary care centre. Using a case-control design, a total of 100 cases and 100 controls were selected between 2016 and 2017. Fresh stool samples were collected and processed for microscopic examination. Positive samples were subjected to PCR RFLP for speciation and results analysed for Odd’s ratio, relative risk and relationship between variables. There was a high male preponderance (m: f=9:1). Most patients belonged to the middle age group (34.8-42.4 years). Amongst the clinical subtype IBS with diarrhoea (IBS-D) was the most common subtype (63%). Odd’s ratio for having IBS was 57.5 with cryptosporidium with a relative risk of 2.09. Adjusted Odd’s ratio for age was 1.014 suggesting a linear correlation (r value=0.07) with age. Our study shows a significant risk of developing IBS with cryptosporidium infection. The authors recommend studies with larger population samples both within the northern regions of India and across the country to determine prevalence, speciation of cryptosporidium and its relationship to IBS.
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