Pub Date : 2022-04-30DOI: 10.32734/idjpcr.v5i1.6910
N. Zebua, Yuni Syafitri, Sudewi, Reza Novriansyah
Wuluh starfruit (Averrhoa bilimbi L.) has a sour taste and high water content which makes the fruit easily damaged and has a short shelf life. It is necessary to process wuluh starfruit in order to obtain a product that has a longer shelf life and tastes better without reducing its benefits. The purpose of this study was to determine the wuluh starfruit in the form of ethanol extract can be formulated into a dry suspension dosage form with arenga gum as a suspension which at a certain concentration can be an optimal suspending agent. Based on the results showed that the ethanol extract of wuluh starfruit (Averrhoa bilimbi L.) could be formulated into a dry suspension. The preparation with 0.5% arenga gum as a suspending agent is the best preparation which has a moisture content of 0.46%, stationary angle of 26.48º, flow time of 4.77 seconds, compressibility index of 18%, particle size distribution 152.133μm, viscosity 106.00 cP, pH 4.16 and sedimentation volume 0.55. Data were analyzed using SPSS 26.0 using one-way analysis of variance (ANOVA) test and post hoc Multiple Comprasions Tukey HSD test.
{"title":"Dry Suspension Formulation of Ethanol Extract from Wuluh Starfruit (Averrhoa bilimbi L.) with Arenga Gum as Suspending Agent","authors":"N. Zebua, Yuni Syafitri, Sudewi, Reza Novriansyah","doi":"10.32734/idjpcr.v5i1.6910","DOIUrl":"https://doi.org/10.32734/idjpcr.v5i1.6910","url":null,"abstract":"Wuluh starfruit (Averrhoa bilimbi L.) has a sour taste and high water content which makes the fruit easily damaged and has a short shelf life. It is necessary to process wuluh starfruit in order to obtain a product that has a longer shelf life and tastes better without reducing its benefits. The purpose of this study was to determine the wuluh starfruit in the form of ethanol extract can be formulated into a dry suspension dosage form with arenga gum as a suspension which at a certain concentration can be an optimal suspending agent. Based on the results showed that the ethanol extract of wuluh starfruit (Averrhoa bilimbi L.) could be formulated into a dry suspension. The preparation with 0.5% arenga gum as a suspending agent is the best preparation which has a moisture content of 0.46%, stationary angle of 26.48º, flow time of 4.77 seconds, compressibility index of 18%, particle size distribution 152.133μm, viscosity 106.00 cP, pH 4.16 and sedimentation volume 0.55. Data were analyzed using SPSS 26.0 using one-way analysis of variance (ANOVA) test and post hoc Multiple Comprasions Tukey HSD test.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89637841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.32734/idjpcr.v5i1.7416
Yustika Wirda Ningsih, A. Nasution, U. Harahap
Primary health centers play important roles in preventing, detecting, and helping people to cope with the problems associated with the COVID-19 infection. Therefore, it is necessary to strengthen and optimize the role of primary health center, including pharmaceutical care. This prospective descriptive study aimed to evaluate the level of patient satisfaction on COVID-19 handling in seven primary health centers Medan, Sumatera Utara, Indonesia period January to April 2021. A self-designed questionnaire was distributed to a total of 617 patients admitted to the 7 primary health centers to assess the characteristics of the patients and the required data about patient satisfaction about nine-item pharmaceutical services provided, supporting facilities, and infrastructures. The patient satisfaction was assessed using a 4-point Likert scale categorized into very dissatisfied, dissatisfied, satisfied and very satisfied. The obtained data were analyzed using descriptive and Chi-Square analyses. Most (67%) of the respondents were females. The present study indicated that most respondents satisfied with the services provided.
{"title":"Patient Satisfaction on Covid-19 Handling in Primary Centers Medan","authors":"Yustika Wirda Ningsih, A. Nasution, U. Harahap","doi":"10.32734/idjpcr.v5i1.7416","DOIUrl":"https://doi.org/10.32734/idjpcr.v5i1.7416","url":null,"abstract":"Primary health centers play important roles in preventing, detecting, and helping people to cope with the problems associated with the COVID-19 infection. Therefore, it is necessary to strengthen and optimize the role of primary health center, including pharmaceutical care. This prospective descriptive study aimed to evaluate the level of patient satisfaction on COVID-19 handling in seven primary health centers Medan, Sumatera Utara, Indonesia period January to April 2021. A self-designed questionnaire was distributed to a total of 617 patients admitted to the 7 primary health centers to assess the characteristics of the patients and the required data about patient satisfaction about nine-item pharmaceutical services provided, supporting facilities, and infrastructures. The patient satisfaction was assessed using a 4-point Likert scale categorized into very dissatisfied, dissatisfied, satisfied and very satisfied. The obtained data were analyzed using descriptive and Chi-Square analyses. Most (67%) of the respondents were females. The present study indicated that most respondents satisfied with the services provided.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75255904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-20DOI: 10.32734/idjpcr.v5i1.6479
Kaban Vera Estefania, J. Silalahi, S. Sumaiyah, D. Satria
The use of plants as a method of herbal treatment is a step that is currently being developed by many researchers to produce effective and minimal side effects. Turmeric is one of the most widely used cooking spices by the people of Indonesia. The main ingredients possessed by turmeric include curcumin (77%), demethoxy (17%) and bisdemethoxy (3%). One of the pharmaceutical preparations with a topical delivery system is a cream preparation which is a semi-solid dosage form, containing one or more drug ingredients dissolved or dispersed in an appropriate base material. Turmeric can be formulated in various preparations, one of which is a cream dosage form. The advantage of using cream preparations is that they are practical, easy to wash and clean. The purpose of this study was to formulate turmeric extract in a cream preparation. The results of the evaluation test showed that the formula produced a cream with a yellow-orange color, a characteristic odor of turmeric, and a preparation with a semisolid cream texture, had good homogeneity, good dispersing ability, the pH of the preparation was 5.84; 6.32; 6.24; 5,94;5,94 and the type of emulsion is O/W (Oil in Water).
利用植物作为草药治疗的一种方法是目前许多研究人员正在开发的一种方法，以产生有效和最小的副作用。姜黄是印度尼西亚人最广泛使用的烹饪香料之一。姜黄的主要成分有姜黄素(77%)、去甲氧基(17%)和双去甲氧基(3%)。具有局部递送系统的药物制剂之一是乳膏制剂，其为半固体剂型，含有溶解或分散在适当基础材料中的一种或多种药物成分。姜黄可以配制成各种制剂，其中一种是乳膏剂型。使用面霜制剂的优点是它们实用，易于清洗和清洁。本研究的目的是在乳膏制剂中配制姜黄提取物。评价试验结果表明，该配方制得的乳膏颜色为黄橙色，具有姜黄特有的气味，且制剂具有半固态乳膏的质地，均匀性好，分散能力好，制剂的pH值为5.84;6.32;6.24;5,94;5,94，乳化液类型为O/W (Oil in Water)。
{"title":"Formulation and Evaluation of Cream Turmeric Extract Preparations from Turmeric Rhizomes (Curcuma domestica Val.)","authors":"Kaban Vera Estefania, J. Silalahi, S. Sumaiyah, D. Satria","doi":"10.32734/idjpcr.v5i1.6479","DOIUrl":"https://doi.org/10.32734/idjpcr.v5i1.6479","url":null,"abstract":"The use of plants as a method of herbal treatment is a step that is currently being developed by many researchers to produce effective and minimal side effects. Turmeric is one of the most widely used cooking spices by the people of Indonesia. The main ingredients possessed by turmeric include curcumin (77%), demethoxy (17%) and bisdemethoxy (3%). One of the pharmaceutical preparations with a topical delivery system is a cream preparation which is a semi-solid dosage form, containing one or more drug ingredients dissolved or dispersed in an appropriate base material. Turmeric can be formulated in various preparations, one of which is a cream dosage form. The advantage of using cream preparations is that they are practical, easy to wash and clean. The purpose of this study was to formulate turmeric extract in a cream preparation. The results of the evaluation test showed that the formula produced a cream with a yellow-orange color, a characteristic odor of turmeric, and a preparation with a semisolid cream texture, had good homogeneity, good dispersing ability, the pH of the preparation was 5.84; 6.32; 6.24; 5,94;5,94 and the type of emulsion is O/W (Oil in Water).","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78542228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.32734/idjpcr.v4i2.6235
Andika Dwi Mahendra
Antibiotic resistance is global issue and the incident is increasing with the use of unwise antibiotic. This study is to describe and evaluate appropriateness of antibiotic prophylaxis selection on Cesarean Section and Hysterectomy procedure. Purpose of study is to evaluate appropiateness of antibiotic selection on cesarean section and hysterectomy. A retrospective study was performed during September 2016 - January 2017 in Private Hospital, Semarang. Data were analized quantitatively using ATC-DDD methodology. Evaluation of antibiotic prophylaxis will be assessed based on The guideline of The American College of Obstetricians and Gynecologists (ACOG) : Antibiotic Prophylaxis for Gynecologic Procedures and The American Society of Health-System Pharmacists (ASHP) : Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Overall, 90 of 95 patients were given antibiotic prophylaxis. The most frequently used antibiotics were ceftriaxone (69.51 DDD/Patient-days) and ceftazidime (14.95 DDD/Patient-days). Appropriate antibiotic selection based on the guidelines for cesarean section procedure was 1.75% and 6.1% for hysterectomy procedure. The use of antibiotic prophylaxis on cesarean section and hysterectomy procedure was very high and less appropriate in the selection. Almost patient received third-generation cephalosporin instead of first-generation cephalosporin such as cefazolin. cefazolin is more effective and narrow spectrum for infection-causing bacteria of these procedures.
{"title":"Antibiotic Use in Cesarean Section and Hysterectomy Procedure: Qualitative and Quantitative Assessment","authors":"Andika Dwi Mahendra","doi":"10.32734/idjpcr.v4i2.6235","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6235","url":null,"abstract":"Antibiotic resistance is global issue and the incident is increasing with the use of unwise antibiotic. This study is to describe and evaluate appropriateness of antibiotic prophylaxis selection on Cesarean Section and Hysterectomy procedure. Purpose of study is to evaluate appropiateness of antibiotic selection on cesarean section and hysterectomy. A retrospective study was performed during September 2016 - January 2017 in Private Hospital, Semarang. Data were analized quantitatively using ATC-DDD methodology. Evaluation of antibiotic prophylaxis will be assessed based on The guideline of The American College of Obstetricians and Gynecologists (ACOG) : Antibiotic Prophylaxis for Gynecologic Procedures and The American Society of Health-System Pharmacists (ASHP) : Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. Overall, 90 of 95 patients were given antibiotic prophylaxis. The most frequently used antibiotics were ceftriaxone (69.51 DDD/Patient-days) and ceftazidime (14.95 DDD/Patient-days). Appropriate antibiotic selection based on the guidelines for cesarean section procedure was 1.75% and 6.1% for hysterectomy procedure. The use of antibiotic prophylaxis on cesarean section and hysterectomy procedure was very high and less appropriate in the selection. Almost patient received third-generation cephalosporin instead of first-generation cephalosporin such as cefazolin. cefazolin is more effective and narrow spectrum for infection-causing bacteria of these procedures. \u0000 ","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86650526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.32734/idjpcr.v4i2.6169
Andre Prayoga, Poppy Anjelisa, Z. Hasibuan
One of the medical needs whose demand continues to increase is wound dressings. The wound cover must also be non-toxic, non-allergenic, made of widely available biomaterials, and have antibacterial properties that can prevent infection of the wound. Chitosan is known to have wound healing activity by acting as a blood-clotting agent and stimulating the formation of new tissue, and silver nanoparticles have good antibacterial activity. Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles is 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0. Then the antibacterial activity was tested against Staphylococcus aureus and Escherichia coli to find the best formula for antibacterial activity. The analysis showed that the SNCCN patch with a ratio of 9:1 had the best antibacterial activity against Staphylococcus aureus (13.8±0.05 mm) and Escherichia coli (12.5±0.05 mm). It can be concluded that patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) have good antibacterial activity at a concentration of 9:1 in the category of strong inhibition (10-20 mm).
{"title":"Antibacterial Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Staphylococcus aureus and Escherichia coli","authors":"Andre Prayoga, Poppy Anjelisa, Z. Hasibuan","doi":"10.32734/idjpcr.v4i2.6169","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6169","url":null,"abstract":"One of the medical needs whose demand continues to increase is wound dressings. The wound cover must also be non-toxic, non-allergenic, made of widely available biomaterials, and have antibacterial properties that can prevent infection of the wound. Chitosan is known to have wound healing activity by acting as a blood-clotting agent and stimulating the formation of new tissue, and silver nanoparticles have good antibacterial activity. Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles is 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0. Then the antibacterial activity was tested against Staphylococcus aureus and Escherichia coli to find the best formula for antibacterial activity. The analysis showed that the SNCCN patch with a ratio of 9:1 had the best antibacterial activity against Staphylococcus aureus (13.8±0.05 mm) and Escherichia coli (12.5±0.05 mm). It can be concluded that patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers carriers (SNCCN) have good antibacterial activity at a concentration of 9:1 in the category of strong inhibition (10-20 mm).","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87079559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.32734/idjpcr.v4i2.6332
Reqgi First Trasi
Artemisinin class of antimalarial drugs play an important role in controlling falciparum malaria after the emergence of resistance of Plasmodium falciparum to other antimalarial drugs such as chloroquine, sulfadoxine-pyrimethamine and mefloquine. Therefore, the presence of Plasmodium falciparum resistance to this class of drugs is threat to global efforts to eliminate this disease. Resistance of Plasmodium falciparum to artemisinin recently known to be associated with mutations in the propeller domain of the kelch-13 (K13) Plasmodium falciparum gene. The incidence of Plasmodium falciparum resistance due to mutations in the K13 gene, among others, can be found in Cambodia, Laos, Vietnam, China, Myanmar, Thailand and Africa. The presence of mutations in this gene will change the response of Plasmodium falciparum against oxidative stress induced by artemisinin by involving the proteasome-ubiquitin pathway. In addition, mutation K13 will also change the levels of PI3K and PI3P in the body of Plasmodium falciparum. PI3K and PI3P are lipids that essential for the development of Plasmodium falciparum from ring stage to schizont. Resistance to artemisinin will also provide phenotypic changes in the life cycle of Plasmodium falciparum in the form of elongation at the stage ring and transient shortening in trophozoite development. This resistance incident can be overcome, among others by prolonging the duration of treatment (from a 3-day regimen to a 4-day regimen) and combining artemisinin with proteasome inhibitors.
{"title":"Plasmodium Resistance to Artemisinin Derivates due to Kelch-3 Gene Mutation","authors":"Reqgi First Trasi","doi":"10.32734/idjpcr.v4i2.6332","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6332","url":null,"abstract":"Artemisinin class of antimalarial drugs play an important role in controlling falciparum malaria after the emergence of resistance of Plasmodium falciparum to other antimalarial drugs such as chloroquine, sulfadoxine-pyrimethamine and mefloquine. Therefore, the presence of Plasmodium falciparum resistance to this class of drugs is threat to global efforts to eliminate this disease. Resistance of Plasmodium falciparum to artemisinin recently known to be associated with mutations in the propeller domain of the kelch-13 (K13) Plasmodium falciparum gene. The incidence of Plasmodium falciparum resistance due to mutations in the K13 gene, among others, can be found in Cambodia, Laos, Vietnam, China, Myanmar, Thailand and Africa. The presence of mutations in this gene will change the response of Plasmodium falciparum against oxidative stress induced by artemisinin by involving the proteasome-ubiquitin pathway. In addition, mutation K13 will also change the levels of PI3K and PI3P in the body of Plasmodium falciparum. PI3K and PI3P are lipids that essential for the development of Plasmodium falciparum from ring stage to schizont. Resistance to artemisinin will also provide phenotypic changes in the life cycle of Plasmodium falciparum in the form of elongation at the stage ring and transient shortening in trophozoite development. This resistance incident can be overcome, among others by prolonging the duration of treatment (from a 3-day regimen to a 4-day regimen) and combining artemisinin with proteasome inhibitors.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83010156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.32734/idjpcr.v4i2.6295
Junius Gian Ginting, Poppy Anjelisa, Z. Hasibuan
Abstract. Wounds that are not treated and are kept open will provide an entrance for microorganisms from outside that can cause infection. One of the medical needs whose demand continues to increase is wound dressings. Chitosan is known to have wound healing activity by stimulating the formation of new tissue, and silver nanoparticles have good antimicrobial activity. Silver nanoparticles and chitosan with cellulose nanofibers carrier are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles are 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0 then tested the antifungal activity against Trichophyton rubrum and Pitysporum ovale for finding the best formula for antifungal activity. The analysis showed that the patch with a ratio of 6:4 had the best antifungal activity against Trichophyton rubrum (14.7±0.1 mm) and a 9:1 patch on the Pitysporum ovale (6.9±0.05 mm) gave a significant difference to negative control (p<0.05). It can be concluded that the Patches Silver Nanoparticle and Chitosan with Cellulose Nanofibers (SNCCN) carriers have good antifungal activity in the inhibitory category.
{"title":"Antifungal Activity of Patch Silver Nanoparticles and Chitosan with Cellulose Nanofibers Carriers against Trichophyton rubrum and Pitysporum ovale","authors":"Junius Gian Ginting, Poppy Anjelisa, Z. Hasibuan","doi":"10.32734/idjpcr.v4i2.6295","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6295","url":null,"abstract":"Abstract. Wounds that are not treated and are kept open will provide an entrance for microorganisms from outside that can cause infection. One of the medical needs whose demand continues to increase is wound dressings. Chitosan is known to have wound healing activity by stimulating the formation of new tissue, and silver nanoparticles have good antimicrobial activity. Silver nanoparticles and chitosan with cellulose nanofibers carrier are made in the form of patches with the ratio formula between cellulose nanofibers and chitosan/silver nanoparticles are 1:9, 2:8, 3:8, 4:7, 5:5, 6:4, 7:3, 8:2, 9:1, and 10:0 then tested the antifungal activity against Trichophyton rubrum and Pitysporum ovale for finding the best formula for antifungal activity. The analysis showed that the patch with a ratio of 6:4 had the best antifungal activity against Trichophyton rubrum (14.7±0.1 mm) and a 9:1 patch on the Pitysporum ovale (6.9±0.05 mm) gave a significant difference to negative control (p<0.05). It can be concluded that the Patches Silver Nanoparticle and Chitosan with Cellulose Nanofibers (SNCCN) carriers have good antifungal activity in the inhibitory category.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"368 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91460900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-30DOI: 10.32734/idjpcr.v4i2.6387
Linnon Bastian Lumbanraja, A. Nasution, A. Dalimunthe
Good drug management including planning, procurement, storage, distribution, destruction, recording and reporting is one of the tasks of the North Sumatra Provincial Health Office and HIV Services in the Regency/City. The purpose of this study was to analyze the drug management of the Antiretroviral program drugs in 2019 and 2020 at the Pharmacy Warehouse of the Health Office of North Sumatra Province, the Pharmacy Installation of Pirngadi Hospital Medan, and Pharmacy Installation at HKBP Balige Hospital. The research was conducted in January-April 2021. This research is descriptive with quantitative data obtained retrospectively and concurrently, qualitative data obtained through observation and interviews with informants. The data obtained were analyzed using indicators and compared to standard research results. The results showed in the North Sumatra Provincial Health Office 5 indicators have not met the standards and 9 indicators have met the standards, in Pirngadi Hospital Medan 4 indicators have not met the standards and 8 indicators have met the standards, but have not done the process of planning drug needs, and in HKBP Balige Hospital there are no indicators that meet the standards and do not do the planning of drug needs. The conclusion of this study is drug planning at the North Sumatra Provincial Health Office using the consumption method of the previous period. Pirngadi Hospital Medan and HKBP Balige Hospital did not plan for drug needs. Drug distribution at the North Sumatra Provincial Health Office uses a decentralized system starting in 2020 from the previous centralized system. In Pirngadi Hospital Medan the system is decentralized, while at HKBP Balige Hospital the distribution system is centralized.
{"title":"Analysis of Antiretroviral Drugs (ARV) Logistic Management in the Province of Sumatera Utara (Case Study: Regional Public Hospital Dr. Pirngadi Medan And Public Hospital HKBP Balige)","authors":"Linnon Bastian Lumbanraja, A. Nasution, A. Dalimunthe","doi":"10.32734/idjpcr.v4i2.6387","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6387","url":null,"abstract":"Good drug management including planning, procurement, storage, distribution, destruction, recording and reporting is one of the tasks of the North Sumatra Provincial Health Office and HIV Services in the Regency/City. The purpose of this study was to analyze the drug management of the Antiretroviral program drugs in 2019 and 2020 at the Pharmacy Warehouse of the Health Office of North Sumatra Province, the Pharmacy Installation of Pirngadi Hospital Medan, and Pharmacy Installation at HKBP Balige Hospital. The research was conducted in January-April 2021. This research is descriptive with quantitative data obtained retrospectively and concurrently, qualitative data obtained through observation and interviews with informants. The data obtained were analyzed using indicators and compared to standard research results. The results showed in the North Sumatra Provincial Health Office 5 indicators have not met the standards and 9 indicators have met the standards, in Pirngadi Hospital Medan 4 indicators have not met the standards and 8 indicators have met the standards, but have not done the process of planning drug needs, and in HKBP Balige Hospital there are no indicators that meet the standards and do not do the planning of drug needs. The conclusion of this study is drug planning at the North Sumatra Provincial Health Office using the consumption method of the previous period. Pirngadi Hospital Medan and HKBP Balige Hospital did not plan for drug needs. Drug distribution at the North Sumatra Provincial Health Office uses a decentralized system starting in 2020 from the previous centralized system. In Pirngadi Hospital Medan the system is decentralized, while at HKBP Balige Hospital the distribution system is centralized.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88442677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harni Sepriyani, Wahyu Margi Sidoretno, Mega Elfia
White and bright skin is everyone's dream. Many women who do facial skin care in order to obtain healthy facial skin and attractive appearance. Facial skin care that is mostly done is the use of facial whitening creams. Face whitening cream is believed to be able to remove or lighten black spots on facial skin. Whitening cream that is often used is a night cream. Some of the night creams sold have not received permission from National Agency of Drug and Food Control of Indonesia. Usually these creams contain heavy metals, such as mercury. Mercury is toxic which when exposed and absorbed by the body can cause loss of enzyme ability in the body to cancer. The purpose of this study was to determine the presence or absence of mercury in the night cream and urine of night cream users at Abdurrab University Midwifery Study Program students. The method of this research is a qualitative examination on samples of night cream and urine used KI reagent. The results showed that the night cream sampled gave a positive test result and the urine of night cream users gave a negative test result. The conclusion of this study is that the night cream sampled contained mercury and the urine of night cream users did not contain mercury.
{"title":"The Identification of Mercury in The Urine of Night Cream Users in Midwifery Program Abdurrab University","authors":"Harni Sepriyani, Wahyu Margi Sidoretno, Mega Elfia","doi":"10.31869/ijpr.v1i2.2831","DOIUrl":"https://doi.org/10.31869/ijpr.v1i2.2831","url":null,"abstract":"White and bright skin is everyone's dream. Many women who do facial skin care in order to obtain healthy facial skin and attractive appearance. Facial skin care that is mostly done is the use of facial whitening creams. Face whitening cream is believed to be able to remove or lighten black spots on facial skin. Whitening cream that is often used is a night cream. Some of the night creams sold have not received permission from National Agency of Drug and Food Control of Indonesia. Usually these creams contain heavy metals, such as mercury. Mercury is toxic which when exposed and absorbed by the body can cause loss of enzyme ability in the body to cancer. The purpose of this study was to determine the presence or absence of mercury in the night cream and urine of night cream users at Abdurrab University Midwifery Study Program students. The method of this research is a qualitative examination on samples of night cream and urine used KI reagent. The results showed that the night cream sampled gave a positive test result and the urine of night cream users gave a negative test result. The conclusion of this study is that the night cream sampled contained mercury and the urine of night cream users did not contain mercury.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73182279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the treatment of inflammation, there are several chemical drugs, namely steroidal and non-steroidal anti-inflammatory drugs, but because they have many side effects, anti-inflammatory drugs are developed from natural ingredients, especially plants. Plants are scientifically proven to have anti-inflammatory properties, one of which is ambarella fruit leaves because it leaves contain flavonoid secondary metabolites as anti-inflammatory compounds. The objective of this study to determine the effect of giving ambarella fruit leaves on anti-inflammatory activity in male rats induced by carrageenan. The method used in this study was paw edema, namely by induction of carrageenan 0.1 ml as an irritant on the soles of the rat's feet for 360 minutes with the parameter observed was the inhibition of edema in the feet of rats using a plethysmometer. This study was an experimental study that was divided into 5 groups, namely the control group positive (diclofenac sodium 9 mg/kgBW), negative control (Na-Cmc 0.55), and three doses tested, namely 100 mg/kgBW, 300 mg/kgBW and 500 mg/kgBW. The results of this study showed a significant difference (p<0.05) where flavonoid compounds from ambarella fruit leaves affect anti-inflammatory activity. The conclusion that the three doses is tested, namely 100 mg/kgBW, 300 mg/kgBW and 500 mg/kgBW has an anti-inflammatory effect where the more effective dose was 300 mg/kg kgBW.
{"title":"Anti-Inflammatory Activity Test of Ethanol Extract of Ambarella Fruit Leaves (Spondias dulcis Frost) Against Male Rats Induced Carrageenan","authors":"Ahmad Syukur Hasibuan","doi":"10.31869/ijpr.v1i2.2830","DOIUrl":"https://doi.org/10.31869/ijpr.v1i2.2830","url":null,"abstract":"In the treatment of inflammation, there are several chemical drugs, namely steroidal and non-steroidal anti-inflammatory drugs, but because they have many side effects, anti-inflammatory drugs are developed from natural ingredients, especially plants. Plants are scientifically proven to have anti-inflammatory properties, one of which is ambarella fruit leaves because it leaves contain flavonoid secondary metabolites as anti-inflammatory compounds. The objective of this study to determine the effect of giving ambarella fruit leaves on anti-inflammatory activity in male rats induced by carrageenan. The method used in this study was paw edema, namely by induction of carrageenan 0.1 ml as an irritant on the soles of the rat's feet for 360 minutes with the parameter observed was the inhibition of edema in the feet of rats using a plethysmometer. This study was an experimental study that was divided into 5 groups, namely the control group positive (diclofenac sodium 9 mg/kgBW), negative control (Na-Cmc 0.55), and three doses tested, namely 100 mg/kgBW, 300 mg/kgBW and 500 mg/kgBW. The results of this study showed a significant difference (p<0.05) where flavonoid compounds from ambarella fruit leaves affect anti-inflammatory activity. The conclusion that the three doses is tested, namely 100 mg/kgBW, 300 mg/kgBW and 500 mg/kgBW has an anti-inflammatory effect where the more effective dose was 300 mg/kg kgBW.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85780981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：