Narcotics, psychotropics, and addictive substances abuse can cause addiction, which is a chronic disorder characterized by compulsive drug seeking and use despite adverse consequences. This is a concurrent descriptive study carried out by evaluating medical records and MMAS-8 questionnaire for assessing patients’ adherence. In addition, therapeutic success and quality of life were also evaluated using WHOQOL-BREF questionnaire. The study took place in the period of September-November 2018 at Medika Antapani Clinic. Data collected from patients under drug maintenance was used to identify the types of drug mostly used by the patients and their treatment, assess the impact of the management, and identify factor influencing therapeutic success. The results showed that there were 40 drug abusers at Medika Antapani Clinic. The abused drugs were amphetamine (80%), cannabis (72%), heroin (35%), benzodiazepine (25%), and nitrazepam (20%). Therapeutic measures used to treat drug abuse were alprazolam in 38 patients (95%), clonazepam in 33 patients (82.5%), nitrazepam in 29 patients (72.5%), lorazepam in 22 patients (55%), and diazepam in 14 patients (35%). Drug rehabilitation patients had low adherence of only 50%. Measurement of quality of life revealed social relation as the dimension with the highest score of 69 + 20.44, with most patients categorized as having moderate quality of life. Therapy with benzodiazepine has potential to cause dependence so it must be practiced with caution.
{"title":"Treatment Pattern of Patients with Narcotics and Psychotropic Abuse (Case Study at the Bandung Rehabilitation Clinic)","authors":"Lively Sergeonery","doi":"10.31869/ijpr.v1i2.2898","DOIUrl":"https://doi.org/10.31869/ijpr.v1i2.2898","url":null,"abstract":"Narcotics, psychotropics, and addictive substances abuse can cause addiction, which is a chronic disorder characterized by compulsive drug seeking and use despite adverse consequences. This is a concurrent descriptive study carried out by evaluating medical records and MMAS-8 questionnaire for assessing patients’ adherence. In addition, therapeutic success and quality of life were also evaluated using WHOQOL-BREF questionnaire. The study took place in the period of September-November 2018 at Medika Antapani Clinic. Data collected from patients under drug maintenance was used to identify the types of drug mostly used by the patients and their treatment, assess the impact of the management, and identify factor influencing therapeutic success. The results showed that there were 40 drug abusers at Medika Antapani Clinic. The abused drugs were amphetamine (80%), cannabis (72%), heroin (35%), benzodiazepine (25%), and nitrazepam (20%). Therapeutic measures used to treat drug abuse were alprazolam in 38 patients (95%), clonazepam in 33 patients (82.5%), nitrazepam in 29 patients (72.5%), lorazepam in 22 patients (55%), and diazepam in 14 patients (35%). Drug rehabilitation patients had low adherence of only 50%. Measurement of quality of life revealed social relation as the dimension with the highest score of 69 + 20.44, with most patients categorized as having moderate quality of life. Therapy with benzodiazepine has potential to cause dependence so it must be practiced with caution.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86388930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Research has been carried out on the activity test of fruit and leave juice of starfruit (Averrhoa bilimbi L. ) against dandruff-causing fungi. It is found that the average diameter of inhibition for the fruite juice of starfruit (Averrhoa bilimbi L. ) are 38.26 mm, 35.53 mm, and 32.17 mm, while the leave juice of starfruit (Averrhoa bilimbi L. ) are 29.01 mm, 27.66 mm, and 25.57 mm for 100%, 75%, and 50% of concentrations respectively. Based on statistical calculations there is no significant difference between the concentrations of 100%, 75%, and 50% where Fcount < Ftable.
{"title":"Activity of Fruit and Leave Juice of Belimbing Wuluh (Averrhoa bilimbi L.) against Dandruff-Causing Fungi","authors":"B. Setiawan","doi":"10.31869/ijpr.v1i2.2514","DOIUrl":"https://doi.org/10.31869/ijpr.v1i2.2514","url":null,"abstract":"Research has been carried out on the activity test of fruit and leave juice of starfruit (Averrhoa bilimbi L. ) against dandruff-causing fungi. It is found that the average diameter of inhibition for the fruite juice of starfruit (Averrhoa bilimbi L. ) are 38.26 mm, 35.53 mm, and 32.17 mm, while the leave juice of starfruit (Averrhoa bilimbi L. ) are 29.01 mm, 27.66 mm, and 25.57 mm for 100%, 75%, and 50% of concentrations respectively. Based on statistical calculations there is no significant difference between the concentrations of 100%, 75%, and 50% where Fcount < Ftable.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74907895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-09DOI: 10.32734/idjpcr.v4i2.6467
S. Kundu, M. A. H. N. A. Khan, S. Das
Mushrooms are considered as a valuable source of important nutrients having hepatoprotective and anti-hyperlipidemic actions. Present experimental research was done to explore the beneficial role of mushroom on health in hypercholesterolemia. Total thirty Swiss albino mice were taken and randomly divided into three groups: control A, group B and group C. Each group consisted of ten mice. The control A group was fed with normal mice pellet and fresh water. Group B was fed with hypercholesterolemic diet and group C was supplied hypercholesterolemic diet with mushroom powder (500g/kg/mice body weight) for 60 days. After the experimental tenure, mice of each group were sacrificed ethically and the samples (liver and blood) were collected for gross, histological study and lipid profile analysis. Increased liver weight, pale and hemorrhagic liver in gross observation along with some histological changes including dilation and congestion of central and portal vein, fat accumulation in hepatocyte and marked lymphocytic infiltration were found in group B, while mushroom supplementation recovered this gross and histological changes and reduced liver weight in group C. Just mild congestion and dilation was in the portal vein of group C. In lipid profile analysis, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) level significantly reduced respectively by 10%, 38% and 17% in group C than group B. High density lipoprotein (HDL) level also significantly increased by 20% in group C compared to group B. Therefore, it can be concluded that mushrooms might have potentially beneficial actions in recovering of some complications in hypercholesterolemia.
{"title":"Beneficial Role of Mushroom in Recovering Complications of Hypercholesterolemia","authors":"S. Kundu, M. A. H. N. A. Khan, S. Das","doi":"10.32734/idjpcr.v4i2.6467","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i2.6467","url":null,"abstract":"Mushrooms are considered as a valuable source of important nutrients having hepatoprotective and anti-hyperlipidemic actions. Present experimental research was done to explore the beneficial role of mushroom on health in hypercholesterolemia. Total thirty Swiss albino mice were taken and randomly divided into three groups: control A, group B and group C. Each group consisted of ten mice. The control A group was fed with normal mice pellet and fresh water. Group B was fed with hypercholesterolemic diet and group C was supplied hypercholesterolemic diet with mushroom powder (500g/kg/mice body weight) for 60 days. After the experimental tenure, mice of each group were sacrificed ethically and the samples (liver and blood) were collected for gross, histological study and lipid profile analysis. Increased liver weight, pale and hemorrhagic liver in gross observation along with some histological changes including dilation and congestion of central and portal vein, fat accumulation in hepatocyte and marked lymphocytic infiltration were found in group B, while mushroom supplementation recovered this gross and histological changes and reduced liver weight in group C. Just mild congestion and dilation was in the portal vein of group C. In lipid profile analysis, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) level significantly reduced respectively by 10%, 38% and 17% in group C than group B. High density lipoprotein (HDL) level also significantly increased by 20% in group C compared to group B. Therefore, it can be concluded that mushrooms might have potentially beneficial actions in recovering of some complications in hypercholesterolemia.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90970228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-28DOI: 10.32734/idjpcr.v4i1.5821
S. Sumaiyah, Meyliana
Canola (Brassica napus L.) oil high in vitamin E is good for skin care. Vitamin E is an effective antioxidant that protects our skin from free radical damage and keeps the skin elasticity, evenness, reduces blemishes, acne scars, and slows down the skin’s aging. This study aimed to formulate canola oil nano cream and find out canola oil nano cream gives a higher anti-aging effect than canola oil cream. Nanocream as anti-aging formulated in four variations of canola oil concentration 2,5%, 5%, 7,5% and 10%. Nanocream was tested IC50, and observed the characteristics and stability. Then, continue to irritation test and anti-aging activity of nanocream compared with cream on the skin of volunteers. The result showed that nanocream of variation canola oil was in a different color and distinctive smell. The preparation was stable in 12 weeks room temperature storage, homogenous, and no phase separation. Particle size was 5882.17 nm, 348.47 nm, 321.16 nm, 318.16 nm initially and increased after 12 weeks. There was no irritation, and anti-aging activity was higher than cream. Canola oil can be formulated as nanocream, stable in 12 weeks storage, and nano cream has higher anti-aging activity than cream.
{"title":"Formulation and Evaluation of Skin Anti-aging Nanocream Containing Canola (Brassica napus L.) Oil","authors":"S. Sumaiyah, Meyliana","doi":"10.32734/idjpcr.v4i1.5821","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5821","url":null,"abstract":"Canola (Brassica napus L.) oil high in vitamin E is good for skin care. Vitamin E is an effective antioxidant that protects our skin from free radical damage and keeps the skin elasticity, evenness, reduces blemishes, acne scars, and slows down the skin’s aging. This study aimed to formulate canola oil nano cream and find out canola oil nano cream gives a higher anti-aging effect than canola oil cream. Nanocream as anti-aging formulated in four variations of canola oil concentration 2,5%, 5%, 7,5% and 10%. Nanocream was tested IC50, and observed the characteristics and stability. Then, continue to irritation test and anti-aging activity of nanocream compared with cream on the skin of volunteers. The result showed that nanocream of variation canola oil was in a different color and distinctive smell. The preparation was stable in 12 weeks room temperature storage, homogenous, and no phase separation. Particle size was 5882.17 nm, 348.47 nm, 321.16 nm, 318.16 nm initially and increased after 12 weeks. There was no irritation, and anti-aging activity was higher than cream. Canola oil can be formulated as nanocream, stable in 12 weeks storage, and nano cream has higher anti-aging activity than cream.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73202488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-28DOI: 10.32734/idjpcr.v4i1.5378
Anggitha Ningtias, Rosidah, Yuandani
Poguntano (Picriafel-terraeLour.) is a medicinal plant in North Sumatra that has been used in traditional medicine to treat degenerative diseases.Poguntano extract contains flavonoid compounds that have the potential to be developed into immunomodulators. This study showed the immunostimulant activity of poguntano herb n-hexane extract (PHNHE), poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) in immunosuppressed rats infected with Staphylococcus aureus. The evidence of poguntano herb as an immunomodulator was carried out by testing total leukocytes and differential leukocytes. Poguntano herb n-hexane extract (PHNHE) can not increase the total and differential leukocytes; Poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) can increase the total and differential leukocytes in immunosuppressed rats induced by Staphylococcus aureus.
{"title":"Poguntano Herba Extract Immunostimulant Activities (Picriafel-terraeLour). in Immunosupression Rats Infected by Staphylococcus aureus Against Total Leukocytes and Differential Leukocytes","authors":"Anggitha Ningtias, Rosidah, Yuandani","doi":"10.32734/idjpcr.v4i1.5378","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5378","url":null,"abstract":"Poguntano (Picriafel-terraeLour.) is a medicinal plant in North Sumatra that has been used in traditional medicine to treat degenerative diseases.Poguntano extract contains flavonoid compounds that have the potential to be developed into immunomodulators. This study showed the immunostimulant activity of poguntano herb n-hexane extract (PHNHE), poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) in immunosuppressed rats infected with Staphylococcus aureus. The evidence of poguntano herb as an immunomodulator was carried out by testing total leukocytes and differential leukocytes. Poguntano herb n-hexane extract (PHNHE) can not increase the total and differential leukocytes; Poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) can increase the total and differential leukocytes in immunosuppressed rats induced by Staphylococcus aureus.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78980443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-28DOI: 10.32734/idjpcr.v4i1.5375
Reqgi First Trasia
Indonesia still has health problem, especially soil transmitted helminth. These helminths can cause deteriorate health, nutrition, intelligence and productivity of patients so causes a lot of losses economically. The aim of this article is to review the rational treatment of helminth infection. Albendazole, mebendazole, and pyrantel pamoate are the drugs recommended by the WHO. However, the uses of the three are different, especially for mass treatment or selective medicine. This review conclude that the three drugs are used according to the target patient's age with dosages and preparations that must be adjusted.
{"title":"Rational Use of Medicine in the Treatment of Helminth Infection : A Mini Review","authors":"Reqgi First Trasia","doi":"10.32734/idjpcr.v4i1.5375","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5375","url":null,"abstract":"Indonesia still has health problem, especially soil transmitted helminth. These helminths can cause deteriorate health, nutrition, intelligence and productivity of patients so causes a lot of losses economically. The aim of this article is to review the rational treatment of helminth infection. Albendazole, mebendazole, and pyrantel pamoate are the drugs recommended by the WHO. However, the uses of the three are different, especially for mass treatment or selective medicine. This review conclude that the three drugs are used according to the target patient's age with dosages and preparations that must be adjusted.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79491149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-30DOI: 10.32734/idjpcr.v4i1.5352
Muhammad Sobri Maulana
Heart failure is one of the major cause of patient’s admittance to the hospital. Primary hypertension is one of the most universal comorbidities that precedes heart failure and is one of the more common risk factors held by the majority of the population. Right now, antihypertension that are generally used is from Angiotensin-Converting Enzyme Inhibitor (ACE-I) and Angiotensin Receptor Blocker (ARB). A new group of an antihypertensive agent called “Angiotensin Receptor Neprilysin Inhibitor (ARNI)” to further improve the patient condition. This study aims to evaluate the effectivity of ARNI against ACE-I regarding its cardiac reverse remodeling effect. Search strategy was done using electronic databases, which are Pubmed, Scopus, and Cochrane. Articles included are therapeutic study that is in line with the clinical question and fulfills the inclusion and exclusion criteria. Critical appraisal was done by assessing the article’s validity, importance, and applicability according to Oxford Center of Evidence-Based Medicine 2011 to two chosen articles. 2 articles are chosen and appraised. Both of the study are shown to be valid and shows that ARNI has a significantly better result on improving cardiac reverse remodeling via the left ventricle ejection fraction compared to ACE-I. However, the applicability of ARNI is still debatable in Indonesia as it was not covered by national insurance and there is no generic form. ARNI shows to be significantly better to reverse cardiac remodeling compared to ACE-I, but its applicability has to be improved to be implemented in Indonesia.
{"title":"The Effctiveness Of Angiotensin Receptor Neprilysin Inhibitor On Improving The Cardiac Remodelling Compared To Ace-Inhibitor On Patients With Chronic Heart Failure","authors":"Muhammad Sobri Maulana","doi":"10.32734/idjpcr.v4i1.5352","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5352","url":null,"abstract":"Heart failure is one of the major cause of patient’s admittance to the hospital. Primary hypertension is one of the most universal comorbidities that precedes heart failure and is one of the more common risk factors held by the majority of the population. Right now, antihypertension that are generally used is from Angiotensin-Converting Enzyme Inhibitor (ACE-I) and Angiotensin Receptor Blocker (ARB). A new group of an antihypertensive agent called “Angiotensin Receptor Neprilysin Inhibitor (ARNI)” to further improve the patient condition. This study aims to evaluate the effectivity of ARNI against ACE-I regarding its cardiac reverse remodeling effect. Search strategy was done using electronic databases, which are Pubmed, Scopus, and Cochrane. Articles included are therapeutic study that is in line with the clinical question and fulfills the inclusion and exclusion criteria. Critical appraisal was done by assessing the article’s validity, importance, and applicability according to Oxford Center of Evidence-Based Medicine 2011 to two chosen articles. 2 articles are chosen and appraised. Both of the study are shown to be valid and shows that ARNI has a significantly better result on improving cardiac reverse remodeling via the left ventricle ejection fraction compared to ACE-I. However, the applicability of ARNI is still debatable in Indonesia as it was not covered by national insurance and there is no generic form. ARNI shows to be significantly better to reverse cardiac remodeling compared to ACE-I, but its applicability has to be improved to be implemented in Indonesia.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78319094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-30DOI: 10.32734/idjpcr.v4i1.5381
Nurahmi Lumban Gaol, Yuandani, P. Sitorus
Fermented onion is a type of onion that produced by heating onion bulbs at high temperature for 15 days by fermenter machine. This research is expected to produce new alternatives therapy for reducing cholesterol from onions especially Allium cepa L. var cepa. In this experimental laboratory used 25 male white rats that divided into five groups, group I: negatif control, group II: positif control (Atorvastatin), group III: 100 mg/Kg body weight (bw) of fermented onion extact, group IV: 200 mg/Kg bw of fermented onion extract and group V: 300 mg/Kg bw of fermented onion extract. The Rats was feeding by an atherogenic diet to makes them hypercholesterolemia before treatment for 7th days, 14th days and 21st days. All of data were analyzed by ANOVA method (significant 0,05). The result concludes that of all the doses tested, fermented onion extract of Allium cepa L. var cepa with a dose of 200 mg/Kg bw has the highest effect in decreasing total cholesterol levels of hypercholesterolemia rats (Rattus novergicus).
{"title":"Evaluation of Antyhipercholesterolemic Effect of Allium cepa L. var cepa in Atherogenic Induced Rats","authors":"Nurahmi Lumban Gaol, Yuandani, P. Sitorus","doi":"10.32734/idjpcr.v4i1.5381","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5381","url":null,"abstract":"Fermented onion is a type of onion that produced by heating onion bulbs at high temperature for 15 days by fermenter machine. This research is expected to produce new alternatives therapy for reducing cholesterol from onions especially Allium cepa L. var cepa. In this experimental laboratory used 25 male white rats that divided into five groups, group I: negatif control, group II: positif control (Atorvastatin), group III: 100 mg/Kg body weight (bw) of fermented onion extact, group IV: 200 mg/Kg bw of fermented onion extract and group V: 300 mg/Kg bw of fermented onion extract. The Rats was feeding by an atherogenic diet to makes them hypercholesterolemia before treatment for 7th days, 14th days and 21st days. All of data were analyzed by ANOVA method (significant 0,05). The result concludes that of all the doses tested, fermented onion extract of Allium cepa L. var cepa with a dose of 200 mg/Kg bw has the highest effect in decreasing total cholesterol levels of hypercholesterolemia rats (Rattus novergicus).","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83904130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-29DOI: 10.32734/idjpcr.v4i1.5382
Raissa Fitri, Julia Reveny, U. Harahap, Hariyadi Dharmawan, Syahputra, N. Nasri
Abstract. Biocellulose mask sheet is a new found pharmaceutical cosmetic design that widely commercial. Mostly due to it’s biodegradable properties, provide an eco-friendly waste. Combination of Aloe vera essence (AE) and Vit E to provide and determine it’s respective anti-acne properties in biocellulose mask form. Formulation of biocellulose mask with the help of Acetobacter xylinum bacteria varied with different formulae: F1 (Vitamin E 1%), F2 (E 2.5 %), F3 (AE 5%), F4 (AE 2.5%+Vit E 1%) and F5 (AE 5%+Vit E 1%) followed antimicrobials test with common acne bacteria by diffusion disk against Propionibacterium acne (PAC) ATCC 6919 and Pseudomonas aeruginosa (PAA) ATCC 27853. Study revealed that each formulae design F1; F2; F3; F4; F5 tested against PAC diffusion disk resulted 7.86; 11.67; 10.13; 112.10; 10.33 mm respectively. As for PAA diffusion disk resulted 7.76; 11.63; 10.33; 11.67; 11.00 mm respectively. Biocellulose mask containing combination of AE 2.5% and Vit E (F4) would provide the best anti-acne activity amongst other formulae.
{"title":"Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E","authors":"Raissa Fitri, Julia Reveny, U. Harahap, Hariyadi Dharmawan, Syahputra, N. Nasri","doi":"10.32734/idjpcr.v4i1.5382","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5382","url":null,"abstract":"Abstract. Biocellulose mask sheet is a new found pharmaceutical cosmetic design that widely commercial. Mostly due to it’s biodegradable properties, provide an eco-friendly waste. Combination of Aloe vera essence (AE) and Vit E to provide and determine it’s respective anti-acne properties in biocellulose mask form. Formulation of biocellulose mask with the help of Acetobacter xylinum bacteria varied with different formulae: F1 (Vitamin E 1%), F2 (E 2.5 %), F3 (AE 5%), F4 (AE 2.5%+Vit E 1%) and F5 (AE 5%+Vit E 1%) followed antimicrobials test with common acne bacteria by diffusion disk against Propionibacterium acne (PAC) ATCC 6919 and Pseudomonas aeruginosa (PAA) ATCC 27853. Study revealed that each formulae design F1; F2; F3; F4; F5 tested against PAC diffusion disk resulted 7.86; 11.67; 10.13; 112.10; 10.33 mm respectively. As for PAA diffusion disk resulted 7.76; 11.63; 10.33; 11.67; 11.00 mm respectively. Biocellulose mask containing combination of AE 2.5% and Vit E (F4) would provide the best anti-acne activity amongst other formulae. \u0000 ","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87094885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The dirty and itchy scalp is very annoying in appearance, which is the onset of dandruff. Dandruff is due to the accumulation of dead skin cells, dry and oily scalp as well as the presence of skin infections and fungi in the head. To avoid the onset of dirt or dandruff to hair, it is necessary to do cleaning regularly using cosmetics one of them is active charcoal-based shampoo palm kernel shells. The capability of palm kernel shells can absorb dirt twice from commercial active charcoal to cleanse the skin to the fullest. This research aims to effectively absorption of the dirt in Invitro on the active charcoal shampoo of palm shells with a concentration of 12%. Invitro tests the effectiveness of the impurities absorbent by using a turbidimetry tool with a Nephelometric Turbidity Unit value or frequency number. While the irritation test is done on 10 people panelists. Comparative control used commercial shampoo as a positive control and base shampoo as a negative control. The results showed that a 12% palm shell activated charcoal shampoo provided an NTU value of 11,400 while a commercial shampoo gave an NTU value of 786. No panelists have irritation on the scalp. From the obtained results can be concluded that the active oil palm Shell Shampoo has the absorbent power to the dirt from a commercial shampoo and safe to use.
{"title":"Irritation Test and Effectiveness of The Clean Power Activated Charcoal Palm Shells (Elaeis guineensis Jacg) as Adsorbent Dirt on The Hair","authors":"Uce Lastari, S. Syamsurizal, Faizar Farid","doi":"10.31869/IJPR.V1I1.2452","DOIUrl":"https://doi.org/10.31869/IJPR.V1I1.2452","url":null,"abstract":"The dirty and itchy scalp is very annoying in appearance, which is the onset of dandruff. Dandruff is due to the accumulation of dead skin cells, dry and oily scalp as well as the presence of skin infections and fungi in the head. To avoid the onset of dirt or dandruff to hair, it is necessary to do cleaning regularly using cosmetics one of them is active charcoal-based shampoo palm kernel shells. The capability of palm kernel shells can absorb dirt twice from commercial active charcoal to cleanse the skin to the fullest. This research aims to effectively absorption of the dirt in Invitro on the active charcoal shampoo of palm shells with a concentration of 12%. Invitro tests the effectiveness of the impurities absorbent by using a turbidimetry tool with a Nephelometric Turbidity Unit value or frequency number. While the irritation test is done on 10 people panelists. Comparative control used commercial shampoo as a positive control and base shampoo as a negative control. The results showed that a 12% palm shell activated charcoal shampoo provided an NTU value of 11,400 while a commercial shampoo gave an NTU value of 786. No panelists have irritation on the scalp. From the obtained results can be concluded that the active oil palm Shell Shampoo has the absorbent power to the dirt from a commercial shampoo and safe to use.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90571601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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