Nutmeg pulp is one part of the nutmeg plant that contain antioxidant to prevent free radicals in the body. Nutmeg pulp contains secondary metabolites of the flavonoid class which have function as antioxidant. This study was conducted to determine the effect of drying the nutmeg pulp on the level of antioxidant activity using the DPPH method. After measuring the antioxidant activity of wind-dried and oven–dried nutmeg using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, the results showed that the antioxidant activity (IC50) of wind dry is 116,952 µg/mL and oven dry is 219,2 µg/mL. The result of one-way Anova data analysis obtain p-value (p)
{"title":"The Effect of Drying Method on The Antioxidant Activity of The Flesh of Nutmeg","authors":"Fita Selonni","doi":"10.31869/IJPR.V1I1.2437","DOIUrl":"https://doi.org/10.31869/IJPR.V1I1.2437","url":null,"abstract":"Nutmeg pulp is one part of the nutmeg plant that contain antioxidant to prevent free radicals in the body. Nutmeg pulp contains secondary metabolites of the flavonoid class which have function as antioxidant. This study was conducted to determine the effect of drying the nutmeg pulp on the level of antioxidant activity using the DPPH method. After measuring the antioxidant activity of wind-dried and oven–dried nutmeg using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, the results showed that the antioxidant activity (IC50) of wind dry is 116,952 µg/mL and oven dry is 219,2 µg/mL. The result of one-way Anova data analysis obtain p-value (p)","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"84 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80980696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
White pomegranate peel has many kinds uses, one of them as antimalaria. The unpleasant appearance and bitter taste of white pomegranate peel tablet can be covered by film coated using Kollicoat Protect. This research aimed to determine the effect of concentration and type of solvent used as a coating on the physical properties of the coated tablets and determine the optimum formula. Tablets were made using direct compression method and then coated using Kollicoat Protect. The optimization of coating formula was performed using a factorial design with design expert software ver 10.0. Responses used were tablet hardness, friability, disintegration time and increasing tablet mass. The results of this study showed that Kollicoat Protect cause increase of weight gain tablets and decrease the tablet friability, but prolong the disintegration time of tablets and decrease the tablet hardness while type of solvent can increase of weight gain tablets, tablet hardness, and decrease the tablet friability but prolong the disintegration time of tablets. The optimum combination formula was Kollicoat Protect at 13.6% and combination of water:alcohol (1:0.863) (w/v) with a theoretical response to weight gain of 2.340%; hardness 7.950 kp; friability 0.022%; and disintegration time 20.938 minutes.
{"title":"Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect","authors":"Stefani Luke, M. Ervina, Lannie Hadisoewignyo","doi":"10.31869/IJPR.V1I1.1993","DOIUrl":"https://doi.org/10.31869/IJPR.V1I1.1993","url":null,"abstract":"White pomegranate peel has many kinds uses, one of them as antimalaria. The unpleasant appearance and bitter taste of white pomegranate peel tablet can be covered by film coated using Kollicoat Protect. This research aimed to determine the effect of concentration and type of solvent used as a coating on the physical properties of the coated tablets and determine the optimum formula. Tablets were made using direct compression method and then coated using Kollicoat Protect. The optimization of coating formula was performed using a factorial design with design expert software ver 10.0. Responses used were tablet hardness, friability, disintegration time and increasing tablet mass. The results of this study showed that Kollicoat Protect cause increase of weight gain tablets and decrease the tablet friability, but prolong the disintegration time of tablets and decrease the tablet hardness while type of solvent can increase of weight gain tablets, tablet hardness, and decrease the tablet friability but prolong the disintegration time of tablets. The optimum combination formula was Kollicoat Protect at 13.6% and combination of water:alcohol (1:0.863) (w/v) with a theoretical response to weight gain of 2.340%; hardness 7.950 kp; friability 0.022%; and disintegration time 20.938 minutes.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80403330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nurwulan Adi Ismaya, Nining Prihatin, Okpri Melia, N. Hasanah
Drug management is the most important management in pharmaceutical services at the pharmacy. Drug storage is an inseparable part of all pharmaceutical activities. Pharmacies including pharmacy service facilities, therefore they must be responsible for drug inventory, maintaining drug supplies to avoid damage and maintaining drug quality. Medicines distributed at pharmacies are the same as drugs distributed in hospitals, therefore a good drug storage system at the pharmacy is the same as storing good medicine in hospitals. This type of research is descriptive research with the main purpose of making an objective picture. Data collection is retrospective by observing and reviewing documents following the drug storage indicators by Pudjaningsih. The population of the study were all medicines. Samples were taken based on the total sampling technique. The research instrument is a stock card and the document resulting from stock opname. The conclusion of this research is an overview of drug storage at Melawai Kemang Pharmacy with indicators suitability of stock card is 97,16 %, percentage of drugs expired and or damaged.
{"title":"Description of Drug Storage in Melawai Kemang Pharmacy in 2018","authors":"Nurwulan Adi Ismaya, Nining Prihatin, Okpri Melia, N. Hasanah","doi":"10.31869/IJPR.V1I1.2436","DOIUrl":"https://doi.org/10.31869/IJPR.V1I1.2436","url":null,"abstract":"Drug management is the most important management in pharmaceutical services at the pharmacy. Drug storage is an inseparable part of all pharmaceutical activities. Pharmacies including pharmacy service facilities, therefore they must be responsible for drug inventory, maintaining drug supplies to avoid damage and maintaining drug quality. Medicines distributed at pharmacies are the same as drugs distributed in hospitals, therefore a good drug storage system at the pharmacy is the same as storing good medicine in hospitals. This type of research is descriptive research with the main purpose of making an objective picture. Data collection is retrospective by observing and reviewing documents following the drug storage indicators by Pudjaningsih. The population of the study were all medicines. Samples were taken based on the total sampling technique. The research instrument is a stock card and the document resulting from stock opname. The conclusion of this research is an overview of drug storage at Melawai Kemang Pharmacy with indicators suitability of stock card is 97,16 %, percentage of drugs expired and or damaged.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82912715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study is an experimental study of stability of creams containing kojic acid and glycolic at 2% using the same cream base. Cream containing kojic acid and glycolic acid are often used as skin whitening. The cream made is observing changes in organoleptic properties, pH, viscosity and homogeneity in storage for 6 weeks. Observations of organoleptic properties including discoloration and cream odor, pH examination using pH meter, viscosity examination using viscometer Brookfield with a spindle speed of 20 rpm while for homogeneity examination using a metallograph with a magnification of 200x. The results showed that base creams and cream containing kojic acid showed better stability on organoleptic observations compared to cream containing glycolic acid. The pH of the cream containing kojic acid is less stable than the cream containing glycolic acid. Viscosity of cream containing kojic acid is more stable than cream containing glycolic acid. On homogeneity testing each cream looks homogeneous. In this study it can be concluded that cream containing kojic acid has better stability than cream containing glycolic acid.
{"title":"The Stability Comparison of Whitening Containing Kojic Acid and Glycolid Acid with The Same Cream Base","authors":"Siska Ferilda","doi":"10.31869/IJPR.V1I1.2429","DOIUrl":"https://doi.org/10.31869/IJPR.V1I1.2429","url":null,"abstract":"This study is an experimental study of stability of creams containing kojic acid and glycolic at 2% using the same cream base. Cream containing kojic acid and glycolic acid are often used as skin whitening. The cream made is observing changes in organoleptic properties, pH, viscosity and homogeneity in storage for 6 weeks. Observations of organoleptic properties including discoloration and cream odor, pH examination using pH meter, viscosity examination using viscometer Brookfield with a spindle speed of 20 rpm while for homogeneity examination using a metallograph with a magnification of 200x. The results showed that base creams and cream containing kojic acid showed better stability on organoleptic observations compared to cream containing glycolic acid. The pH of the cream containing kojic acid is less stable than the cream containing glycolic acid. Viscosity of cream containing kojic acid is more stable than cream containing glycolic acid. On homogeneity testing each cream looks homogeneous. In this study it can be concluded that cream containing kojic acid has better stability than cream containing glycolic acid.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79424243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-08DOI: 10.32734/idjpcr.v3i2.4430
M. Yunus, Wiryanto, Yuandani
The pharmacy installation is one of the units in the hospital that provides. service products and services in the form of prescription services. Prescription service asthe front line of pharmacy services to patients must be managed properly becausethe quality of pharmaceutical prescription service which is generally associated with the speed ingiving service. This research is a descriptive type of research with prospective data collection from March-June 2019 to evaluate the waiting time for outpatient prescription services at the Hospital Pharmacy Installation of the Universitas Sumatera Utara. The data taken were 357 outpatient prescriptions.The results of this study indicate the total average length of time waiting for outpatients for the provision of non-fake drugs at the Pharmacy Installation of Outpatients at the University of Sumatera Utara Hospital at 09.00 - 11.00 is 29.10 minutes, at 11.00 - 13.00 is 34.44. minutes and at 13.00 - finished 42.60 minutes. The average length of waiting time for outpatients for the provision of compound drugs at the Outpatient Pharmacy Installation of the University of Sumatera Utara Hospital at 09.00 - 11.00 is 51.67 minutes, 11.00 - 13.00 hours is 62.27 minutes and at 13.00 - completion was 65.71 minutes. The waiting time for prescription services is ≤ 60 minutes.Based on the results of research conducted at the Outpatient Pharmacy Installation at the University of Sumatera Utara Hospital, non-concocted prescription drugs meet the requirements if the service time speed is ≤ 30 minutes and the concocted drug prescription fulfills the requirements if the service time speed is ≤ 60 minutes.
{"title":"Evaluation of Waiting Time for Outpatient Prescription Services at the Pharmacy Installation at the Universitas Sumatera Utara Hospital","authors":"M. Yunus, Wiryanto, Yuandani","doi":"10.32734/idjpcr.v3i2.4430","DOIUrl":"https://doi.org/10.32734/idjpcr.v3i2.4430","url":null,"abstract":"The pharmacy installation is one of the units in the hospital that provides. service products and services in the form of prescription services. Prescription service asthe front line of pharmacy services to patients must be managed properly becausethe quality of pharmaceutical prescription service which is generally associated with the speed ingiving service. This research is a descriptive type of research with prospective data collection from March-June 2019 to evaluate the waiting time for outpatient prescription services at the Hospital Pharmacy Installation of the Universitas Sumatera Utara. The data taken were 357 outpatient prescriptions.The results of this study indicate the total average length of time waiting for outpatients for the provision of non-fake drugs at the Pharmacy Installation of Outpatients at the University of Sumatera Utara Hospital at 09.00 - 11.00 is 29.10 minutes, at 11.00 - 13.00 is 34.44. minutes and at 13.00 - finished 42.60 minutes. The average length of waiting time for outpatients for the provision of compound drugs at the Outpatient Pharmacy Installation of the University of Sumatera Utara Hospital at 09.00 - 11.00 is 51.67 minutes, 11.00 - 13.00 hours is 62.27 minutes and at 13.00 - completion was 65.71 minutes. The waiting time for prescription services is ≤ 60 minutes.Based on the results of research conducted at the Outpatient Pharmacy Installation at the University of Sumatera Utara Hospital, non-concocted prescription drugs meet the requirements if the service time speed is ≤ 30 minutes and the concocted drug prescription fulfills the requirements if the service time speed is ≤ 60 minutes.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86057030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.32734/IDJPCR.V3I2.4311
Reza Destri Anggi, Yuandani, A. Dalimunthe
The purpose of the research was to evaluate the teratogenic effect caused by theprovision of Arabica coffee solution with variations of 0.36 ml, 0.72 ml and 1.08 ml withpositive control of caffeine at a dose of 300 mg / kg bw to rats during organogenesis. Themeasurement parameters in this study are the appearance of reproduction, externalmalformations and scalal malformations. The results in this study found that theadministration of Arabica coffee solution with a volume of 1.08 ml and caffeine 300 mg /kg bb caused an abnormality in the reproductive appearance of weight loss and body length,whereas for extrenal malformation and scalal malforation no abnormalities were found ineach administration of the solution Arabica coffee and caffeine.
{"title":"Teratogenic Effects of Arabica Coffee (Coffea arabica L) on Rats During the Organogenesis Period","authors":"Reza Destri Anggi, Yuandani, A. Dalimunthe","doi":"10.32734/IDJPCR.V3I2.4311","DOIUrl":"https://doi.org/10.32734/IDJPCR.V3I2.4311","url":null,"abstract":"The purpose of the research was to evaluate the teratogenic effect caused by theprovision of Arabica coffee solution with variations of 0.36 ml, 0.72 ml and 1.08 ml withpositive control of caffeine at a dose of 300 mg / kg bw to rats during organogenesis. Themeasurement parameters in this study are the appearance of reproduction, externalmalformations and scalal malformations. The results in this study found that theadministration of Arabica coffee solution with a volume of 1.08 ml and caffeine 300 mg /kg bb caused an abnormality in the reproductive appearance of weight loss and body length,whereas for extrenal malformation and scalal malforation no abnormalities were found ineach administration of the solution Arabica coffee and caffeine.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"26 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89686818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.32734/idjpcr.v4i1.5360
Suharyanisa, P. Hasibuan, P. Nasution
Menopause was a condition of the body when ovaries stopped producing ovum; ovum is the main producer of estrogen hormone. Menopause can increasing lipid profile in blood; it causes any problems in the cardiovascular system. People of North Sumatra have long used Bangun-Bangun leaves as a breastfeeding agent; it contains flavonoid bioactive compounds, which are be expected to replace lost estrogen hormone. This study determined the estrogenic activity of Bangun-Bangun leaves ethanol extract (BBLEE) on lipid levels of ovariectomized female rats as a menopausal model. BBLEE has obtained by maceration techniques with 96% ethanol and extract used on 24 ovariectomized rats which were divided into 6 groups. Group 1 (normal), group 2 (positive) was treated by estradiol at dose of 0.18 mg/kg BW, group 3 (negative) was treated by 0.5% Na-CMC and group 4, 5, 6 were treated by BBLEE at dose of 30, 60, 90 mg/kg BW given orally for 14 days. The data were analyzed by ANOVA and Post Hoc Tukey HSD test. The result showed that effective dose of BBLEE was 90 mg/kg BW which improved lipid profile (TC = 55.75±0.47; TG = 63.00±0.40; HDL = 37.00±0.81; LDL = 30.50±0.86) in blood of ovariectomized female rats as a menopausal model. BBLEE at the dose of 90 mg/kg BW can ameliorate the lipid profile in the blood of ovariectomized female rats as a menopausal model.
{"title":"Effect Of Bangun-Bangun Leaves Ethanol Extract On Lipid Profile Ovariectomized Female Rats","authors":"Suharyanisa, P. Hasibuan, P. Nasution","doi":"10.32734/idjpcr.v4i1.5360","DOIUrl":"https://doi.org/10.32734/idjpcr.v4i1.5360","url":null,"abstract":"Menopause was a condition of the body when ovaries stopped producing ovum; ovum is the main producer of estrogen hormone. Menopause can increasing lipid profile in blood; it causes any problems in the cardiovascular system. People of North Sumatra have long used Bangun-Bangun leaves as a breastfeeding agent; it contains flavonoid bioactive compounds, which are be expected to replace lost estrogen hormone. This study determined the estrogenic activity of Bangun-Bangun leaves ethanol extract (BBLEE) on lipid levels of ovariectomized female rats as a menopausal model. BBLEE has obtained by maceration techniques with 96% ethanol and extract used on 24 ovariectomized rats which were divided into 6 groups. Group 1 (normal), group 2 (positive) was treated by estradiol at dose of 0.18 mg/kg BW, group 3 (negative) was treated by 0.5% Na-CMC and group 4, 5, 6 were treated by BBLEE at dose of 30, 60, 90 mg/kg BW given orally for 14 days. The data were analyzed by ANOVA and Post Hoc Tukey HSD test. The result showed that effective dose of BBLEE was 90 mg/kg BW which improved lipid profile (TC = 55.75±0.47; TG = 63.00±0.40; HDL = 37.00±0.81; LDL = 30.50±0.86) in blood of ovariectomized female rats as a menopausal model. BBLEE at the dose of 90 mg/kg BW can ameliorate the lipid profile in the blood of ovariectomized female rats as a menopausal model.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76778685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.32734/idjpcr.v3i2.5129
Dumartina Hutauruk, Khairunnisa, Wiryanto
This study aimed to examine the effect of adherence to clinical outcomes and the quality of life of primary hypertension patients in pharmacy. The studywas conducted cross sectionally involved 60 patients at one of the pharmacies in Medan, Indonesia. Adherence was obtained in the form of adherence levels measured using the MMAS-8 questionnaire, clinical outcomes assessed by measuring a patient's blood pressure, and quality of life assessed using the EQ-5D-3L questionnaire. Then the data were analyzed using the Spearmen rho test. Patients who participated in the study consisted of 24 men and 36 women. Almost patient has low adherence with blood pressure mean of 156/ 90 mmHg. The patient's quality of life was 77.7%. Adherence has a significant relationship to clinical outcomes (p<0.05) with a strong correlation of r= -0.745. Adherence has a relationship to quality of life (p<0.05) with moderate correlation r= 0.554. This study concluded that adherence has a correlation with clinical outcomes and the quality of life of primary hypertension patients.
{"title":"Effect of Adherence with Clinical Outcomes and Quality of Life Primary Hypertension Patients in Pharmacy","authors":"Dumartina Hutauruk, Khairunnisa, Wiryanto","doi":"10.32734/idjpcr.v3i2.5129","DOIUrl":"https://doi.org/10.32734/idjpcr.v3i2.5129","url":null,"abstract":"This study aimed to examine the effect of adherence to clinical outcomes and the quality of life of primary hypertension patients in pharmacy. The studywas conducted cross sectionally involved 60 patients at one of the pharmacies in Medan, Indonesia. Adherence was obtained in the form of adherence levels measured using the MMAS-8 questionnaire, clinical outcomes assessed by measuring a patient's blood pressure, and quality of life assessed using the EQ-5D-3L questionnaire. Then the data were analyzed using the Spearmen rho test. Patients who participated in the study consisted of 24 men and 36 women. Almost patient has low adherence with blood pressure mean of 156/ 90 mmHg. The patient's quality of life was 77.7%. Adherence has a significant relationship to clinical outcomes (p<0.05) with a strong correlation of r= -0.745. Adherence has a relationship to quality of life (p<0.05) with moderate correlation r= 0.554. This study concluded that adherence has a correlation with clinical outcomes and the quality of life of primary hypertension patients.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79371163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.32734/IDJPCR.V3I2.4306
Rezza Fikrih Utama, Rosidah, Yuandani
Poguntano Herb Plants (Picria fel-terrae Lour.) contains flavonoids compounds that have been potentially to developed into immunomodulators. The purpose of this study was to determine the immunomodulatory activity of Poguntano herb extract (Picria fel-terrae Lour.), with the method of carbon clearance. n-hexane extract puguntano herb(ENHHP), extract of ethyl acetate of Poguntano herb (EEAHP), and ethanol extract of puguntano herb(EEHP) Poguntano multistage results in the test of immunomodulatory activity with a method of carbon clearance. Results showed that the EEHP 200 mg/kg BB showed a strong immunostimulation effect, EEAHP 200 mg/kg BB showed strong immunostimulation effect, ENHP 200 mg/kg BB demonstrated strong immunostimulation effect. It is thought that extract N-hexane herb Poguntano (ENHHP), extracts of ethyl herb acetate Poguntano (EEAHP), and herb ethanol extract Poguntano (EEHP) Poguntano herb may increase phagocytosis activity. Extract of ethyl acetate Poguntano herb 200 mg/kg bw (EEAHP) has the best phagocytosis activity with a value of 2.376 which indicates there is a significant difference (P < 0.05) with another treatment group.
{"title":"Immunomodulator Activity of Puguntano (Picria fel-terrae Lour.) Extract in White Male Mice By Carbon Clearance Method","authors":"Rezza Fikrih Utama, Rosidah, Yuandani","doi":"10.32734/IDJPCR.V3I2.4306","DOIUrl":"https://doi.org/10.32734/IDJPCR.V3I2.4306","url":null,"abstract":"Poguntano Herb Plants (Picria fel-terrae Lour.) contains flavonoids compounds that have been potentially to developed into immunomodulators. The purpose of this study was to determine the immunomodulatory activity of Poguntano herb extract (Picria fel-terrae Lour.), with the method of carbon clearance. n-hexane extract puguntano herb(ENHHP), extract of ethyl acetate of Poguntano herb (EEAHP), and ethanol extract of puguntano herb(EEHP) Poguntano multistage results in the test of immunomodulatory activity with a method of carbon clearance. Results showed that the EEHP 200 mg/kg BB showed a strong immunostimulation effect, EEAHP 200 mg/kg BB showed strong immunostimulation effect, ENHP 200 mg/kg BB demonstrated strong immunostimulation effect. It is thought that extract N-hexane herb Poguntano (ENHHP), extracts of ethyl herb acetate Poguntano (EEAHP), and herb ethanol extract Poguntano (EEHP) Poguntano herb may increase phagocytosis activity. Extract of ethyl acetate Poguntano herb 200 mg/kg bw (EEAHP) has the best phagocytosis activity with a value of 2.376 which indicates there is a significant difference (P < 0.05) with another treatment group.","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74164864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.32734/idjpcr.v3i2.4556
Syilvi Rinda Sari, Khairunnisa, A. Dalimunthe
Evaluation of Drug Management of Pharmacy Installation at Universitas Sumatera Utara Hospital
苏门答腊北方大学医院药房设备药品管理评价
{"title":"Evaluation of Drug Management of Pharmacy Installation at Universitas Sumatera Utara Hospital","authors":"Syilvi Rinda Sari, Khairunnisa, A. Dalimunthe","doi":"10.32734/idjpcr.v3i2.4556","DOIUrl":"https://doi.org/10.32734/idjpcr.v3i2.4556","url":null,"abstract":"Evaluation of Drug Management of Pharmacy Installation at Universitas Sumatera Utara Hospital","PeriodicalId":13466,"journal":{"name":"Indonesian Journal of Pharmaceutical and Clinical Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88505024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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