Pub Date : 2023-10-26DOI: 10.32771/inajog.v11i4.2083
A. K. Harzif, M. Natadisastra, Dwi A. Suryandari, Retno A. Werdhani, W. Jatmiko, Arief Budiono, Hartanto Bayuaji, B. Wiweko
Objective: To determine the potential of examining embryo morphology, and morphokinetic parameters in predicting the chromosomal status of embryos. Methods: This study is a cross-sectional that requires patients undergoing IVF followed by chromosome examination with NGS that was conducted at the IVF Center at Pondok Indah Hospital and Morula IVF Center at Bunda Hospital from December 2021 to December 2022. Each embryo that reaches the blastocyst stage on day 5 or 6 will be washed and put into a PCR tube for a week; then, embryologists annotate them to determine morphological assessment and morphokinetic parameters using Time-Lapse Microscopy. The chi-square test was used to analyse bivariate variables. Results: One hundred twenty-four samples were collected on day 5 of patients undergoing the IVF procedure. 50.8% of the samples were aneuploid chromosomes, and 49.2% were euploid. The morphokinetic characteristics median was 3.86 fold. It was found that expansion grade, time to pro-nuclear fading, and time to the synchrony of the third cell cycle were significantly associated with euploid status (p = 0.000; 0.041 and 0.036). Conclusion: The expansion grade has been proven as the most influential component for accurately predicting the ploidy status of embryos. Keyword: blastocyst, embryo, euploid status, expansion grade, morphokinetics Abstrak Tujuan: Untuk mengetahui potensi pemeriksaan morfologi embrio, dan parameter morfokinetik dalam memprediksi status kromosom embrio. Metode: Penelitian ini merupakan penelitian potong lintang yang memerlukan pasien yang sedang menjalani program bayi tabung yang dilanjutkan dengan pemeriksaan kromosom dengan NGS yang dilakukan di Pusat IVF RS Pondok Indah dan Pusat IVF Morula RS Bunda pada bulan Desember 2021 hingga Desember 2022. Setiap embrio yang mencapai tahap blastokista pada hari ke 5 atau 6 akan dicuci dan dimasukkan ke dalam tabung PCR selama seminggu; kemudian, ahli embriologi membuat anotasi untuk menentukan penilaian morfologi dan parameter morfokinetik menggunakan Mikroskop Time-Lapse. Uji chi-square digunakan untuk menganalisis variabel bivariat. Hasil: Seratus dua puluh empat sampel dikumpulkan pada hari ke 5 dari pasien yang menjalani prosedur IVF. 50,8% sampel adalah kromosom aneuploid, dan 49,2% adalah euploid. Median karakteristik morfokinetik sebesar 3,86 kali lipat. Ditemukan bahwa tingkat ekspansi, waktu menuju pemudaran pro-nuklir, dan waktu hingga sinkronisasi siklus sel ketiga berhubungan secara signifikan dengan status euploid (p = 0,000; 0,041 dan 0,036). Kesimpulan: Tingkat ekspansi telah terbukti sebagai komponen yang paling berpengaruh dalam memprediksi status ploidi embrio secara akurat. Kata kunci: blastosist, embrio, status euploid, tingkat ekspansi, morfokinetik
{"title":"Expansion Grade and Morphokinetic Parameters Associated with Aneuploidy Status of Embryo Fifth Day","authors":"A. K. Harzif, M. Natadisastra, Dwi A. Suryandari, Retno A. Werdhani, W. Jatmiko, Arief Budiono, Hartanto Bayuaji, B. Wiweko","doi":"10.32771/inajog.v11i4.2083","DOIUrl":"https://doi.org/10.32771/inajog.v11i4.2083","url":null,"abstract":"Objective: To determine the potential of examining embryo morphology, and morphokinetic parameters in predicting the chromosomal status of embryos. Methods: This study is a cross-sectional that requires patients undergoing IVF followed by chromosome examination with NGS that was conducted at the IVF Center at Pondok Indah Hospital and Morula IVF Center at Bunda Hospital from December 2021 to December 2022. Each embryo that reaches the blastocyst stage on day 5 or 6 will be washed and put into a PCR tube for a week; then, embryologists annotate them to determine morphological assessment and morphokinetic parameters using Time-Lapse Microscopy. The chi-square test was used to analyse bivariate variables. Results: One hundred twenty-four samples were collected on day 5 of patients undergoing the IVF procedure. 50.8% of the samples were aneuploid chromosomes, and 49.2% were euploid. The morphokinetic characteristics median was 3.86 fold. It was found that expansion grade, time to pro-nuclear fading, and time to the synchrony of the third cell cycle were significantly associated with euploid status (p = 0.000; 0.041 and 0.036). Conclusion: The expansion grade has been proven as the most influential component for accurately predicting the ploidy status of embryos. Keyword: blastocyst, embryo, euploid status, expansion grade, morphokinetics Abstrak Tujuan: Untuk mengetahui potensi pemeriksaan morfologi embrio, dan parameter morfokinetik dalam memprediksi status kromosom embrio. Metode: Penelitian ini merupakan penelitian potong lintang yang memerlukan pasien yang sedang menjalani program bayi tabung yang dilanjutkan dengan pemeriksaan kromosom dengan NGS yang dilakukan di Pusat IVF RS Pondok Indah dan Pusat IVF Morula RS Bunda pada bulan Desember 2021 hingga Desember 2022. Setiap embrio yang mencapai tahap blastokista pada hari ke 5 atau 6 akan dicuci dan dimasukkan ke dalam tabung PCR selama seminggu; kemudian, ahli embriologi membuat anotasi untuk menentukan penilaian morfologi dan parameter morfokinetik menggunakan Mikroskop Time-Lapse. Uji chi-square digunakan untuk menganalisis variabel bivariat. Hasil: Seratus dua puluh empat sampel dikumpulkan pada hari ke 5 dari pasien yang menjalani prosedur IVF. 50,8% sampel adalah kromosom aneuploid, dan 49,2% adalah euploid. Median karakteristik morfokinetik sebesar 3,86 kali lipat. Ditemukan bahwa tingkat ekspansi, waktu menuju pemudaran pro-nuklir, dan waktu hingga sinkronisasi siklus sel ketiga berhubungan secara signifikan dengan status euploid (p = 0,000; 0,041 dan 0,036). Kesimpulan: Tingkat ekspansi telah terbukti sebagai komponen yang paling berpengaruh dalam memprediksi status ploidi embrio secara akurat. Kata kunci: blastosist, embrio, status euploid, tingkat ekspansi, morfokinetik","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139313246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-25DOI: 10.32771/inajog.v11i1.1652
Taufik S. Ismail, Putri Irmayani, K. Kulsum
Objectives: To resolve ethical conflicts in medical decision making in unmarried patients with a diagnosis of ovarian cancer. The ethical issue in this case is the main operative management in cases of ovarian cancer, namely removal of the uterus and both ovaries even though the patient is not married and has never been pregnant. The opportunity for patients to get pregnant no longer exists, so there is an ethical conflict between medical indications and patient preferences.Methods: This case report is about an unmarried woman 38- year with a diagnosis of ovarian cancer. This patient initially underwent right salfingooophorectomy surgery. Anatomical pathology results found adenocarcinoma serosum ovarii. The patient underwent chemotherapy for 3 cycles. Then the patient was re-operated with a planned debulking interval laparotomy.Discussion: From the aspect of patient indications, the results of combination treatment between surgery and chemotherapy have shown a marked increase in the survival rate of patients in five years. The choice of performing a debulking interval laparotomy is a difficult choice. The patient's preference to get pregnant will be difficult to accept, but it can be accommodated by improving the quality of life and paying attention to humanism, social and cultural aspects of its contextual features.Conclusion: Clinical ethical considerations related to uterine removal in unmarried patients is a matter of debate. Clinical ethical theory namely quality of life, patient preferences, medical indications, and contextual features are beneficial in medical decision making.Keywords: debulking intervals, ethical conflicts, medical indications, ovarian cancer, patient preferences.Tujuan: Untuk menyelesaikan konflik etik dalam pengambilan keputusan medik pada pasien yang belum menikah dengan diagnosis kanker ovarium. Isu etik pada kasus ini yaitu manajemen operatif utama pada kasuskanker ovarium yaitu pengangkatan uterus dan kedua ovarium padahal pasien belum menikah dan belum pernah hamil. Kesempatan untuk pasien untuk hamil tidak ada lagi sehingga terjadi pertentangan etik antara indikasi medik dengan preferensi pasien.Metode: Laporan kasus ini tentang seorang pasien perempuan yang belum menikah, berusia 38 tahun dengandiagnose kanker ovarium. Pasien ini awalnya dilakukan operasi salfingoooforektomi kanan. Hasil patologi anatomi ditemukan adenokarsinoma serosum ovari. Pasien menjalani kemoterapi sebanyak 3 siklus. Kemudian pasien dilakukan operasi kembali yang direncanakan tindakan laparotomi interval debulking.Diskusi: Dari aspek indikasi pasien, hasil pengobatan kombinasi antara pembedahan dan kemoterapi telahmenunjukkan peningkatan survival rate yang nyata pada pasien dalam lima tahun. Pilihan melakukan tindakanlaparotomi interval debulking merupakan pilihan sulit. Preferensi pasien untuk dapat hamil akan sulit dikabulkan, namun dapat diakomodir dengan peningkatan kualitas hidup dan memperhatikan aspek humanism, sosial dan kultural pa
{"title":"Resolution of ethical conflicts between medical indications and patient preferences in case of unmarried woman with ovarian cancer","authors":"Taufik S. Ismail, Putri Irmayani, K. Kulsum","doi":"10.32771/inajog.v11i1.1652","DOIUrl":"https://doi.org/10.32771/inajog.v11i1.1652","url":null,"abstract":"Objectives: To resolve ethical conflicts in medical decision making in unmarried patients with a diagnosis of ovarian cancer. The ethical issue in this case is the main operative management in cases of ovarian cancer, namely removal of the uterus and both ovaries even though the patient is not married and has never been pregnant. The opportunity for patients to get pregnant no longer exists, so there is an ethical conflict between medical indications and patient preferences.Methods: This case report is about an unmarried woman 38- year with a diagnosis of ovarian cancer. This patient initially underwent right salfingooophorectomy surgery. Anatomical pathology results found adenocarcinoma serosum ovarii. The patient underwent chemotherapy for 3 cycles. Then the patient was re-operated with a planned debulking interval laparotomy.Discussion: From the aspect of patient indications, the results of combination treatment between surgery and chemotherapy have shown a marked increase in the survival rate of patients in five years. The choice of performing a debulking interval laparotomy is a difficult choice. The patient's preference to get pregnant will be difficult to accept, but it can be accommodated by improving the quality of life and paying attention to humanism, social and cultural aspects of its contextual features.Conclusion: Clinical ethical considerations related to uterine removal in unmarried patients is a matter of debate. Clinical ethical theory namely quality of life, patient preferences, medical indications, and contextual features are beneficial in medical decision making.Keywords: debulking intervals, ethical conflicts, medical indications, ovarian cancer, patient preferences.Tujuan: Untuk menyelesaikan konflik etik dalam pengambilan keputusan medik pada pasien yang belum menikah dengan diagnosis kanker ovarium. Isu etik pada kasus ini yaitu manajemen operatif utama pada kasuskanker ovarium yaitu pengangkatan uterus dan kedua ovarium padahal pasien belum menikah dan belum pernah hamil. Kesempatan untuk pasien untuk hamil tidak ada lagi sehingga terjadi pertentangan etik antara indikasi medik dengan preferensi pasien.Metode: Laporan kasus ini tentang seorang pasien perempuan yang belum menikah, berusia 38 tahun dengandiagnose kanker ovarium. Pasien ini awalnya dilakukan operasi salfingoooforektomi kanan. Hasil patologi anatomi ditemukan adenokarsinoma serosum ovari. Pasien menjalani kemoterapi sebanyak 3 siklus. Kemudian pasien dilakukan operasi kembali yang direncanakan tindakan laparotomi interval debulking.Diskusi: Dari aspek indikasi pasien, hasil pengobatan kombinasi antara pembedahan dan kemoterapi telahmenunjukkan peningkatan survival rate yang nyata pada pasien dalam lima tahun. Pilihan melakukan tindakanlaparotomi interval debulking merupakan pilihan sulit. Preferensi pasien untuk dapat hamil akan sulit dikabulkan, namun dapat diakomodir dengan peningkatan kualitas hidup dan memperhatikan aspek humanism, sosial dan kultural pa","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139314078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-28DOI: 10.32771/inajog.v11i3.2116
N. Wibowo
Vitamin D serves not only to control and maintain the regulation of essential minerals like calcium and phosphorous in bones but also plays a crucial role in various functions throughout the human body. It is involved in regulating inflammation, free radicals, the immune system, cell proliferation, differentiation, and the prevention of various diseases such as infections, autoimmune disorders, cancer, and metabolic conditions like diabetes and thyroid issues. Within the field of obstetrics and gynecology, vitamin D is known to play a significant role in conditions like PCO (polycystic ovary), Endometriosis, Ovarian Cancer, Cervical Cancer, Preterm birth, preeclampsia, Gestational Diabetes Mellitus (GDM), and Intrauterine Growth Restriction (IUGR). In essence, vitamin D is a key player in reproductive health. Unfortunately, existing research shows that both pregnant and non-pregnant women in Indonesia generally have insufficient levels of vitamin D, even though comprehensive studies like riskedas have not been conducted yet. In pregnant women with early-onset preeclampsia, fetal growth delays, or preterm births (both early and late onset), their vitamin D levels are lower compared to those of normal pregnant women. The human body can naturally produce vitamin D with the help of sunlight, and Indonesia, being located near the equator, receives abundant sunlight. If low vitamin D levels are detected, the possible reasons could include; Pregnant women having insufficient exposure to sunlight at specific times, inadequate intake of pro-vitamin D nutrients, the presence of genetic variations in enzymes responsible for providing active vitamin D, or Vitamin D requirements surpassing intake and production. Research needs to be conducted on these four conditions. However, given Indonesia’s vast geographical area, sampling from various regions is necessary, requiring significant efforts and funding. The initial step involves collecting and reviewing all existing research on vitamin D during pregnancy in Indonesia. Subsequently, a research framework focusing on vitamin D (and nutrients in general) during pregnancy, including preparations up to BioBank level, should be developed. This research framework can then be proposed to Bapenas (National Development Planning Agency).
{"title":"The Existing Facts Regarding the Level of Vitamin D in Pregnant Women in Indonesia","authors":"N. Wibowo","doi":"10.32771/inajog.v11i3.2116","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.2116","url":null,"abstract":"Vitamin D serves not only to control and maintain the regulation of essential minerals like calcium and phosphorous in bones but also plays a crucial role in various functions throughout the human body. It is involved in regulating inflammation, free radicals, the immune system, cell proliferation, differentiation, and the prevention of various diseases such as infections, autoimmune disorders, cancer, and metabolic conditions like diabetes and thyroid issues. Within the field of obstetrics and gynecology, vitamin D is known to play a significant role in conditions like PCO (polycystic ovary), Endometriosis, Ovarian Cancer, Cervical Cancer, Preterm birth, preeclampsia, Gestational Diabetes Mellitus (GDM), and Intrauterine Growth Restriction (IUGR). In essence, vitamin D is a key player in reproductive health. Unfortunately, existing research shows that both pregnant and non-pregnant women in Indonesia generally have insufficient levels of vitamin D, even though comprehensive studies like riskedas have not been conducted yet. In pregnant women with early-onset preeclampsia, fetal growth delays, or preterm births (both early and late onset), their vitamin D levels are lower compared to those of normal pregnant women. The human body can naturally produce vitamin D with the help of sunlight, and Indonesia, being located near the equator, receives abundant sunlight. If low vitamin D levels are detected, the possible reasons could include; Pregnant women having insufficient exposure to sunlight at specific times, inadequate intake of pro-vitamin D nutrients, the presence of genetic variations in enzymes responsible for providing active vitamin D, or Vitamin D requirements surpassing intake and production. Research needs to be conducted on these four conditions. However, given Indonesia’s vast geographical area, sampling from various regions is necessary, requiring significant efforts and funding. The initial step involves collecting and reviewing all existing research on vitamin D during pregnancy in Indonesia. Subsequently, a research framework focusing on vitamin D (and nutrients in general) during pregnancy, including preparations up to BioBank level, should be developed. This research framework can then be proposed to Bapenas (National Development Planning Agency).","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46823544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.32771/inajog.v11i3.1881
E. Kurniawati, Gatut Hardianto, T. H. S. Hadi, Hari Paraton, A. Widyasari, N. A. Rahmawati
Objective: To review the role of probiotics in urinary tractinfections in womenMethods: Systematic review was conducted by searchingfi ve databases with several keywords, namely “urinary tractinfection”, “cystitis”, “women” and “probiotics”. Articles thathave gone through peer review are included in the studyif they meet the inclusion and exclusion criteria. Reportingfollows the PRISMA rules.Results: The women included in this study varied from earlyadulthood to postmenopausal, most of whom were sexuallyactive, used birth control methods, and had recurrenturinary tract infections. The results showed that the use ofprobiotics in varied outcomes, either positive or not showedsignifi cant results. This is also due to the differences in theoutcomes studied and the additional materials used. Thisalso contributed to the emergence of adverse effects.Conclusion: The use of probiotics in the treatment ofcystitis and urinary tract infections has hope, although notall studies show signifi cant results. The side effects foundare still tolerable although they need to be considered.Keywords: cystitis, probiotic, urinary tract infection, women.AbstrakTujuan: Meninjau peran probiotik dalam infeksi salurankemih pada perempuan.Metode: Tinjauan sistematis dilakukan dengan mencari limadatabase dengan beberapa kata kunci, yaitu “infeksi salurankemih”, “sistitis”, “perempuan” dan “probiotik”. Artikel yangtelah melalui peer review diikutsertakan dalam penelitianjika memenuhi kriteria inklusi dan eksklusi. Pelaporanmengikuti aturan PRISMA.Hasil: Perempuan yang diikutsertakan dalam penelitian inibervariasi mulai dari dewasa awal hingga pascamenopause,sebagian besar aktif secara seksual, menggunakan metodekontrasepsi, dan mengalami infeksi saluran kemih berulang.Hasil penelitian menunjukkan bahwa penggunaan probiotikpada infeksi saluran kemih menunjukkan hasil yang positifmaupun tidak menunjukkan hasil yang signifi kan. Hal inijuga disebabkan perbedaan outcome dan bahan tambahanyang digunakan. Penggunaan bahan juga berkontribusipada munculnya efek samping.Kesimpulan: Penggunaan probiotik dalam pengobatansistitis dan infeksi saluran kemih memiliki harapan, walaupuntidak semua penelitian menunjukkan hasil yang signifi kan.Efek samping yang ditemukan masih dapat ditoleransimeskipun perlu diperhatikan.Kata kunci: infeksi saluran kemih, perempuan, probiotik,sistitis.
{"title":"The Role of Probiotics in Urinary Tract Infections in Women","authors":"E. Kurniawati, Gatut Hardianto, T. H. S. Hadi, Hari Paraton, A. Widyasari, N. A. Rahmawati","doi":"10.32771/inajog.v11i3.1881","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1881","url":null,"abstract":"Objective: To review the role of probiotics in urinary tractinfections in womenMethods: Systematic review was conducted by searchingfi ve databases with several keywords, namely “urinary tractinfection”, “cystitis”, “women” and “probiotics”. Articles thathave gone through peer review are included in the studyif they meet the inclusion and exclusion criteria. Reportingfollows the PRISMA rules.Results: The women included in this study varied from earlyadulthood to postmenopausal, most of whom were sexuallyactive, used birth control methods, and had recurrenturinary tract infections. The results showed that the use ofprobiotics in varied outcomes, either positive or not showedsignifi cant results. This is also due to the differences in theoutcomes studied and the additional materials used. Thisalso contributed to the emergence of adverse effects.Conclusion: The use of probiotics in the treatment ofcystitis and urinary tract infections has hope, although notall studies show signifi cant results. The side effects foundare still tolerable although they need to be considered.Keywords: cystitis, probiotic, urinary tract infection, women.AbstrakTujuan: Meninjau peran probiotik dalam infeksi salurankemih pada perempuan.Metode: Tinjauan sistematis dilakukan dengan mencari limadatabase dengan beberapa kata kunci, yaitu “infeksi salurankemih”, “sistitis”, “perempuan” dan “probiotik”. Artikel yangtelah melalui peer review diikutsertakan dalam penelitianjika memenuhi kriteria inklusi dan eksklusi. Pelaporanmengikuti aturan PRISMA.Hasil: Perempuan yang diikutsertakan dalam penelitian inibervariasi mulai dari dewasa awal hingga pascamenopause,sebagian besar aktif secara seksual, menggunakan metodekontrasepsi, dan mengalami infeksi saluran kemih berulang.Hasil penelitian menunjukkan bahwa penggunaan probiotikpada infeksi saluran kemih menunjukkan hasil yang positifmaupun tidak menunjukkan hasil yang signifi kan. Hal inijuga disebabkan perbedaan outcome dan bahan tambahanyang digunakan. Penggunaan bahan juga berkontribusipada munculnya efek samping.Kesimpulan: Penggunaan probiotik dalam pengobatansistitis dan infeksi saluran kemih memiliki harapan, walaupuntidak semua penelitian menunjukkan hasil yang signifi kan.Efek samping yang ditemukan masih dapat ditoleransimeskipun perlu diperhatikan.Kata kunci: infeksi saluran kemih, perempuan, probiotik,sistitis.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48830621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.32771/inajog.v11i3.1814
Sherin Sausan Wulandari, Krisdiana Wijayanti, Lanny Sunarjo, Efek Mannihot, Esculenta pada Tingkat, Hormon Prolaktin, dan Produksi, Susu Ibu, Ibu Menyusui, Wijayanti Wulandari
Objective: To prove the effect of cassava leaves jerky(Mannihot Esculennta) on prolactin hormone levels andbreast milk production in breastfeeding mothers in theWorking Area of the Rejosari Health Center of PekanbaruCity.Methods: This study used True Experiment Design with apretest and posttest design with the control group, usinga simple random sampling with a total of 28 breastfeedingmothers, 14 intervention group respondents, and 14 controlgroup respondents. The intervention group was givencassava leaves jerky 60 gr/day, and the control group wasgiven jerky without cassava leaves 20 gr/day for 2 weeks.Both groups were observed 3 times by weighing the baby'sweight and checking the level of the hormone prolactin afteradministering the intervention using the ELISA method. Dataanalysis using Mann-Whitney, TIndependent, RepeatedANOVA test.Results: There was a difference in the average differenceof prolactin hormone levels in the intervention group andcontrol group with a p-value of 0.000 (<0.05)Conclusion: Giving jerky cassava leaves breast milk boosteraffects the hormone prolactin and breast milk production inbreastfeeding mothers.Keywords: breast milk production, cassava leaves, mannihotesculenta, prolactin.Abstrak Tujuan: Untuk Membuktikan dendeng daun singkong(Mannihot Esculennta) terhadap kadar hormon prolaktindan produksi ASI pada ibu menyusui di Wilayah KerjaPuskesmas Rejosari Kota Pekanbaru.Metode: Penelitian ini menggunakan rancangan percobaanyang sebenarnya dengan desain pretest and posttest onlywith control group, sampling menggunakan sampel acaksederhana dengan jumlah 28 responden ibu menyusui,14 responden kelompok intervensi, dan 14 respondenkelompok kontrol. Kelompok intervensi diberi dendeng daunsingkong 60 gr/hari, dan kelompok kontrol diberi dendengtanpa daun singkong 20 gr/hari selama 2 minggu. Keduakelompok diamati sebanyak 3 kali dengan menimbangberat badan bayi dan pemeriksaan kadar hormon prolaktinsetelah pemberian intervensi dengan metode ELISA. Analisisdata menggunakan uji Mann-Whitney, TIndependent,Repeated ANOVA.Hasil: Terdapat perbedaan rata-rata selisih kadar hormonprolaktin pada kelompok intervensi 376,5 ng/ml, kelompokkontrol 103,5 ng/ml dengan p-value 0,000 (<0,05)Kesimpulan: Pemberian dendeng penambah ASI daunsingkong berpengaruh terhadap hormon prolaktin danproduksi ASI pada ibu menyusui.Kata kunci: daun singkong, mannihot esculenta, produksiASI, prolaktin.
目的:探讨木薯叶牛肉干对北干市瑞萨里保健中心工作区哺乳妇女泌乳激素水平和泌乳量的影响。方法:本研究采用真实实验设计，对照组采用前测和后测设计，采用简单随机抽样，共抽取28名母乳喂养母亲，干预组14名被调查者，对照组14名被调查者。干预组给予木薯叶牛肉干60克/天，对照组给予不含木薯叶牛肉干20克/天，连续2周。两组均采用酶联免疫吸附法(ELISA)对干预后的婴儿体重和泌乳素水平进行3次观察。数据分析采用Mann-Whitney, t - independent, RepeatedANOVA检验。结果:干预组与对照组泌乳素水平的平均差异p值为0.000，差异有统计学意义(p <0.05)。结论:给予木薯干叶母乳助推器对哺乳期母亲泌乳素激素及泌乳量有影响。关键词:母乳分泌，木薯叶，甘露糖，催乳素【摘要】图juan: Untuk Membuktikan dendeng daun singkong(Mannihot esculenta) terhadap kadar hormonprolaktindan produksi ASI pada ibu menyusui di Wilayah KerjaPuskesmas rejsari Kota Pekanbaru。方法:Penelitian ini menggunakan rancangan percobaangan sebenanya dengan设计前测和后测，仅与对照组比较，抽取menggunakan样本，其中28例被试，14例被试干预，14例被试对照。龙柏干预龙柏60 gr/hari，龙柏控制龙柏20 gr/hari，龙柏控制龙柏2 mg /hari。Keduakelompok diamati sebanyak 3 kali dengan menimbangberat badan bari dan permeriksaan kadar激素促生因子pengan干预因子ELISA试剂盒。分析数据:Mann-Whitney，独立、重复方差分析。实验结果:Terdapat perbedaan和rata-rata selisih kadar激素促生长素pada kelompok干预376,5 ng/ml, kelompok对照103,5 ng/ml，邓加p-value 0(< 0.05);实验结果:Pemberian dendeneng penambah - daunsingkong berpengaru - terhadap激素促生长素pada danproduksi ASI pakada ibu menusui。Kata kunci:香港黎明，甘露，产品asi, prolaktin。
{"title":"The Effect of Mannihot Esculenta on Prolactin Hormone Levels and Breast Milk Production in Breastfeeding Mothers","authors":"Sherin Sausan Wulandari, Krisdiana Wijayanti, Lanny Sunarjo, Efek Mannihot, Esculenta pada Tingkat, Hormon Prolaktin, dan Produksi, Susu Ibu, Ibu Menyusui, Wijayanti Wulandari","doi":"10.32771/inajog.v11i3.1814","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1814","url":null,"abstract":"Objective: To prove the effect of cassava leaves jerky(Mannihot Esculennta) on prolactin hormone levels andbreast milk production in breastfeeding mothers in theWorking Area of the Rejosari Health Center of PekanbaruCity.Methods: This study used True Experiment Design with apretest and posttest design with the control group, usinga simple random sampling with a total of 28 breastfeedingmothers, 14 intervention group respondents, and 14 controlgroup respondents. The intervention group was givencassava leaves jerky 60 gr/day, and the control group wasgiven jerky without cassava leaves 20 gr/day for 2 weeks.Both groups were observed 3 times by weighing the baby'sweight and checking the level of the hormone prolactin afteradministering the intervention using the ELISA method. Dataanalysis using Mann-Whitney, TIndependent, RepeatedANOVA test.Results: There was a difference in the average differenceof prolactin hormone levels in the intervention group andcontrol group with a p-value of 0.000 (<0.05)Conclusion: Giving jerky cassava leaves breast milk boosteraffects the hormone prolactin and breast milk production inbreastfeeding mothers.Keywords: breast milk production, cassava leaves, mannihotesculenta, prolactin.Abstrak Tujuan: Untuk Membuktikan dendeng daun singkong(Mannihot Esculennta) terhadap kadar hormon prolaktindan produksi ASI pada ibu menyusui di Wilayah KerjaPuskesmas Rejosari Kota Pekanbaru.Metode: Penelitian ini menggunakan rancangan percobaanyang sebenarnya dengan desain pretest and posttest onlywith control group, sampling menggunakan sampel acaksederhana dengan jumlah 28 responden ibu menyusui,14 responden kelompok intervensi, dan 14 respondenkelompok kontrol. Kelompok intervensi diberi dendeng daunsingkong 60 gr/hari, dan kelompok kontrol diberi dendengtanpa daun singkong 20 gr/hari selama 2 minggu. Keduakelompok diamati sebanyak 3 kali dengan menimbangberat badan bayi dan pemeriksaan kadar hormon prolaktinsetelah pemberian intervensi dengan metode ELISA. Analisisdata menggunakan uji Mann-Whitney, TIndependent,Repeated ANOVA.Hasil: Terdapat perbedaan rata-rata selisih kadar hormonprolaktin pada kelompok intervensi 376,5 ng/ml, kelompokkontrol 103,5 ng/ml dengan p-value 0,000 (<0,05)Kesimpulan: Pemberian dendeng penambah ASI daunsingkong berpengaruh terhadap hormon prolaktin danproduksi ASI pada ibu menyusui.Kata kunci: daun singkong, mannihot esculenta, produksiASI, prolaktin.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46168556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.32771/inajog.v11i3.1968
A. Andrijono, D. Wulandari, I. Widyahening, Dicky Mahardhika, N. Nurainy, Rini Mulia Sari, Indriastuti Soetomo, Revata Utama
Objective: Detection of high-risk human papillomavirus (hr-HPV) in urine specimens has been introduced recently and a new local PCR kit has been developed in Indonesia (CerviScan, Bio Farma). The objective of this study was to obtain the accuracy of hr-HPV DNA testing using the new kit (CerviScan, Bio Farma) on urine specimens against the gold standard on cervical swabs.Method: Adult women (aged 20–50 years) underwent routine general check-up or Pap test were enrolled between July and September 2022. Pairs of urine and cervical swab specimens were obtained from all subjects. HPV-DNA tests were performed using the new local PCR kit (CerviScan, Bio Farma) and the standard procedure (COBAS® 6800 HPV, Roche Molecular System). Direct sequencing was added whenever there were dispute results between the two methods. Agreement between both methods was tested using Kappa statistics. Diagnostic performance test was done on CerviScan. Results: A total of 876 women completed the examination. Agreement between CerviScan and COBAS® 6800 was substantial (K=0.662; p<0.001) and was almost perfect against COBAS® 6800 plus sequencing (K=0.828; p<0.001). The accuracy of CerviScan on urine samples was 95.8% against COBAS® 6800 and increased to 97.8% after additional sequencing. The sensitivity and specificity of CerviScan on urine samples compared to cervical swabs are 73.1% and 97.3%, respectively.Conclusion: Urine-based HPV-DNA testing with CerviScan is a reliable tool to detect high-risk HPV subtypes. It could become an alternative method for HPV-DNA testing to improve the coverage of cervical cancer screening program.
目的:印度尼西亚最近引进了尿液标本中高危人乳头瘤病毒(hr-HPV)的检测方法，并开发了一种新的本地PCR试剂盒(CerviScan, Bio Farma)。本研究的目的是获得使用新试剂盒(CerviScan, Bio Farma)对尿液标本进行hr-HPV DNA检测的准确性，以对照宫颈拭子的金标准。方法:于2022年7月至9月接受常规全身检查或巴氏试验的成年女性(20-50岁)。收集所有受试者的成对尿液和宫颈拭子标本。使用新的本地PCR试剂盒(CerviScan, Bio Farma)和标准程序(COBAS®6800 HPV，罗氏分子系统)进行HPV- dna检测。当两种方法结果有争议时，增加直接测序。采用Kappa统计检验两种方法的一致性。在CerviScan上进行诊断性能测试。结果:共有876名女性完成了检查。CerviScan和COBAS®6800之间的一致性是显著的(K=0.662;p<0.001)，对COBAS®6800 +测序几乎完美(K=0.828;p < 0.001)。针对COBAS®6800,CerviScan在尿液样本上的准确性为95.8%，在额外测序后提高到97.8%。与宫颈拭子相比，CerviScan对尿样的敏感性和特异性分别为73.1%和97.3%。结论:CerviScan尿液HPV- dna检测是检测高危HPV亚型的可靠工具。它可能成为HPV-DNA检测的一种替代方法，以提高宫颈癌筛查计划的覆盖率。
{"title":"Diagnostic Performance of Urine-based HPV-DNA Test (CerviScan, Bio Farma) as Cervical Cancer Screening Tool in Adult Women","authors":"A. Andrijono, D. Wulandari, I. Widyahening, Dicky Mahardhika, N. Nurainy, Rini Mulia Sari, Indriastuti Soetomo, Revata Utama","doi":"10.32771/inajog.v11i3.1968","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1968","url":null,"abstract":"Objective: Detection of high-risk human papillomavirus (hr-HPV) in urine specimens has been introduced recently and a new local PCR kit has been developed in Indonesia (CerviScan, Bio Farma). The objective of this study was to obtain the accuracy of hr-HPV DNA testing using the new kit (CerviScan, Bio Farma) on urine specimens against the gold standard on cervical swabs.Method: Adult women (aged 20–50 years) underwent routine general check-up or Pap test were enrolled between July and September 2022. Pairs of urine and cervical swab specimens were obtained from all subjects. HPV-DNA tests were performed using the new local PCR kit (CerviScan, Bio Farma) and the standard procedure (COBAS® 6800 HPV, Roche Molecular System). Direct sequencing was added whenever there were dispute results between the two methods. Agreement between both methods was tested using Kappa statistics. Diagnostic performance test was done on CerviScan. Results: A total of 876 women completed the examination. Agreement between CerviScan and COBAS® 6800 was substantial (K=0.662; p<0.001) and was almost perfect against COBAS® 6800 plus sequencing (K=0.828; p<0.001). The accuracy of CerviScan on urine samples was 95.8% against COBAS® 6800 and increased to 97.8% after additional sequencing. The sensitivity and specificity of CerviScan on urine samples compared to cervical swabs are 73.1% and 97.3%, respectively.Conclusion: Urine-based HPV-DNA testing with CerviScan is a reliable tool to detect high-risk HPV subtypes. It could become an alternative method for HPV-DNA testing to improve the coverage of cervical cancer screening program.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43558084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Objective : To perform transvaginal ultrasound-guided radiofrequency ablation (RFA) to four women with symptomatic subserous and intramural leiomyomas using standard protocols. Methods : A report of four cases. Case : This article reports three of four women with leiomyomas had heavy menstruation bleeding. The first case was a premenopausal woman with pelvic discomfort. In the second case, the patient underwent curettage after being diagnosed with a blighted ovum, the third case with non-cyclic pain and irregular cycles, and the fourth case with 14-year-old infertility and repeated IVF failure. No significant side effects or complications occurred after treatment and during observation. Monitoring uterine leiomyoma size for one week and three months showed an average reduction of 56.9%, indicating a significant reduction in myoma volume. The reported symptoms also improved. Conclusion : Transvaginal ultrasound-guided radiofrequency ablation is an effective, non-invasive therapy with minimal side effects, so it may be the primary choice for leiomyoma therapy. Keywords : Leiomyoma, RFA, transvaginal ultrasonography Abstrak Objektif : Untuk melakukan radiofrekuensi ablasi (RFA) terpandu ultrasonografi transvaginal pada empat wanita dengan mioma intramural dan suberosa bergejala dengan menggunakan protokol yang standar. Metode : Laporan empat kasus. Kasus : Melaporkan tigas dari empat wanita dengan mioma uteri mengalami perdarahan menstruasi yang banyak. Kasus pertama adalah seorang wanita premenopause dengan keluhan rasa tidak nyaman pada panggul. Pada kasus kedua, pasien menjalani kuretase setelah didiagnosis dengan blighted ovum, kasus ketiga dengan nyeri non-siklus dan siklus tidak teratur, dan kasus keempat adalah infertilitas 14 tahun dan kegagalan IVF berulang. Tidak ada efek samping yang berarti atau komplikasi yang terjadi setelah tindakan dan selama pemantauan. Pemantauan ukuran mioma uteri selama satu minggu dan tiga bulan menunjukkan penurunan rata-rata sebesar 56,9%, menunjukkan penurunan volume mioma yang signifikan. Gejala-gejala yang dilaporkan juga mengalami perbaikan. Kesimpulan : Radiofrekuensi ablasi terpandu ultrasonografi transvaginal merupakan terapi non-invasif yang efektif dengan efek samping minimal, sehingga dapat menjadi pilihan utama untuk terapi mioma uteri. Kata kunci : Mioma, RFA, ultrasonografi transvaginal
摘要目的:对4例有症状的浆膜下和壁内平滑肌瘤进行经阴道超声引导射频消融(RFA)治疗。方法:报告4例病例。病例:这篇文章报道了四分之三的女性平滑肌瘤有大量的月经出血。第一个病例是绝经前妇女盆腔不适。第2例患者在诊断为卵萎后进行了刮除，第3例患者出现非周期性疼痛和不规则周期，第4例患者14岁不孕并多次IVF失败。治疗后及观察期间无明显副作用及并发症发生。监测子宫平滑肌瘤大小1周和3个月平均缩小56.9%，表明肌瘤体积明显缩小。报告的症状也有所改善。结论:经阴道超声引导下射频消融术是一种有效、无创、副作用小的治疗方法，可作为平滑肌瘤治疗的首选方法。【摘要】目的:经阴道超声检查、经阴道阴道乳头瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤、子宫内膜瘤。方法:Laporan empat kasus。Kasus: Melaporkan tigas dari empat wanita dengan mioma uteri mengalami perdarahan menstrasi yang banyak。Kasus pertama adalah seorang wanita绝经前登根克鲁汉rasa tidak nyaman pada panggul。Pada kasus kedua, pasen menjalani kuretase setelah诊断dengan枯萎卵，kasus ketiga dengan nyeri non-siklus and siklus tidak terur, dankasus keempat adalah intilitas 14 tahun dan kegagalan IVF berulang。我想我是说，我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是说我是。Pemantauan ukuran mioma uteri selama satu minggu dan tiga bulan menunjukkan penurunan rata-rata sebesar 56,9%， menunjukkan penurunan体积mioma yang显著。Gejala-gejala yang破旧不堪。超声检查:经阴道超声检查无创子宫内膜炎、子宫内膜炎、子宫内膜炎、子宫内膜炎、子宫内膜炎。Kata kunci: Mioma, RFA，经阴道超声检查
{"title":"Leiomyoma Ablation with Transvaginal Ultrasonography-Guided Radiofrequency: A Report of Four Cases","authors":"Doddy Sutanto, Ery Surya Sevriana, Rukmono Siswishanto, Lydia Olivia, Rahmalina","doi":"10.32771/inajog.v11i3.1834","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1834","url":null,"abstract":"Abstract \u0000Objective : To perform transvaginal ultrasound-guided radiofrequency ablation (RFA) to four women with symptomatic subserous and intramural leiomyomas using standard protocols. \u0000Methods : A report of four cases. \u0000Case : This article reports three of four women with leiomyomas had heavy menstruation bleeding. The first case was a premenopausal woman with pelvic discomfort. In the second case, the patient underwent curettage after being diagnosed with a blighted ovum, the third case with non-cyclic pain and irregular cycles, and the fourth case with 14-year-old infertility and repeated IVF failure. No significant side effects or complications occurred after treatment and during observation. Monitoring uterine leiomyoma size for one week and three months showed an average reduction of 56.9%, indicating a significant reduction in myoma volume. The reported symptoms also improved. \u0000Conclusion : Transvaginal ultrasound-guided radiofrequency ablation is an effective, non-invasive therapy with minimal side effects, so it may be the primary choice for leiomyoma therapy. \u0000Keywords : Leiomyoma, RFA, transvaginal ultrasonography \u0000Abstrak \u0000Objektif : Untuk melakukan radiofrekuensi ablasi (RFA) terpandu ultrasonografi transvaginal pada empat wanita dengan mioma intramural dan suberosa bergejala dengan menggunakan protokol yang standar. \u0000Metode : Laporan empat kasus. \u0000Kasus : Melaporkan tigas dari empat wanita dengan mioma uteri mengalami perdarahan menstruasi yang banyak. Kasus pertama adalah seorang wanita premenopause dengan keluhan rasa tidak nyaman pada panggul. Pada kasus kedua, pasien menjalani kuretase setelah didiagnosis dengan blighted ovum, kasus ketiga dengan nyeri non-siklus dan siklus tidak teratur, dan kasus keempat adalah infertilitas 14 tahun dan kegagalan IVF berulang. Tidak ada efek samping yang berarti atau komplikasi yang terjadi setelah tindakan dan selama pemantauan. Pemantauan ukuran mioma uteri selama satu minggu dan tiga bulan menunjukkan penurunan rata-rata sebesar 56,9%, menunjukkan penurunan volume mioma yang signifikan. Gejala-gejala yang dilaporkan juga mengalami perbaikan. \u0000Kesimpulan : Radiofrekuensi ablasi terpandu ultrasonografi transvaginal merupakan terapi non-invasif yang efektif dengan efek samping minimal, sehingga dapat menjadi pilihan utama untuk terapi mioma uteri. \u0000Kata kunci : Mioma, RFA, ultrasonografi transvaginal","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48911609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.32771/inajog.v11i3.1877
Hanif Reza, Shinta Prawitasari, Ardhanu Kusumanto
Objective: To determine the effectiveness of intravenousinjection of granisetron compared to ondansetron inpreventing nausea and vomiting, we used the MASCCAntiemesis Tool (MAT) in ovarian cancer patients undergoingpaclitaxel-carboplatin chemotherapyMethods: This study was conducted as a double-blind,randomized controlled trial. The treatment group received1 mg of granisetron, whereas the control group received8 mg of ondansetron intravenously. Nausea and vomitingwere assessed using the MAT scale at 12 hours, 24 hours,and 48 hours after chemotherapy. The differences in MATscores between the groups were analyzed using the Mann-Whitney test.Results: A total of 60 participants were enrolled in thisstudy. The results indicated that the MAT score at the 12-hour mark significantly differed from the 24-hour and 48-hour MAT scores (p = 0.00, p = 0.00). The MAT scores in thegranisetron group at 12 hours, 24 hours, and 48 hours werestatistically lower compared to the ondansetron group (p =0.00, p = 0.00, p = 0.00).Conclusions: In conclusion, intravenous granisetron provedto be more effective than intravenous ondansetron inpreventing nausea and vomiting among patients with ovariancancer undergoing paclitaxel-carboplatin chemotherapy.Keywords: chemotherapy, granisetron, MAT score,ondansetron, ovarian cancer.AbstrakTujuan: Mengetahui efektivitas perbandingan pemberianinjeksi intravena antara granisetron dan ondansetrondalam mencegah mual dan muntah dengan menggunakanMAT pada pasien dengan kanker ovarium yang mendapatkemoterapi dengan regimen paclitaxel-carboplatin.Metode: Penelitian ini merupakan double blind randomizedcontrolled trial dengan kelompok perlakuan diberikangranisetron 1 mg dan kelompok kontrol yang diberikaninjeksi ondansetron 8mg. Kemudian dilakukan penilaianterhadap mual dan muntah dengan menggunakan skorMAT pada 12 jam, 24 jam, dan 48 jam setelah diberikankemoterapi dengan menggunakan Mann-Whitney testkarena distribusi data tidak normal.Hasil: Total sampel pada penelitian ini adalah 60 subjek.Hasil skor MAT pada 12 jam berbeda bermakna dengan skorMAT 24 jam dan skor MAT 48 jam (p= 0,00, p= 0,00. Terdapatperbedaan bermakna secara statistik pada pengaruh terapigranisetron dan ondansetron terhadap skor MAT 12 jam, 24jam, dan 48 jam (p= 0,00, p= 0,00, p= 0,00).Kesimpulan: Pemberian injeksi granisetron intravena lebihefektif mencegah mual dan muntah dengan menggunakanMAT dibandingkan dengan injeksi ondansetron intravenapada pasien dengan kanker ovarium yang mendapatkemoterapi paclitaxel-carboplatin.Kata kunci: kemoterapi, granisetron, kanker ovarium,ondansetron, skor MAT.
{"title":"Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial","authors":"Hanif Reza, Shinta Prawitasari, Ardhanu Kusumanto","doi":"10.32771/inajog.v11i3.1877","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1877","url":null,"abstract":"Objective: To determine the effectiveness of intravenousinjection of granisetron compared to ondansetron inpreventing nausea and vomiting, we used the MASCCAntiemesis Tool (MAT) in ovarian cancer patients undergoingpaclitaxel-carboplatin chemotherapyMethods: This study was conducted as a double-blind,randomized controlled trial. The treatment group received1 mg of granisetron, whereas the control group received8 mg of ondansetron intravenously. Nausea and vomitingwere assessed using the MAT scale at 12 hours, 24 hours,and 48 hours after chemotherapy. The differences in MATscores between the groups were analyzed using the Mann-Whitney test.Results: A total of 60 participants were enrolled in thisstudy. The results indicated that the MAT score at the 12-hour mark significantly differed from the 24-hour and 48-hour MAT scores (p = 0.00, p = 0.00). The MAT scores in thegranisetron group at 12 hours, 24 hours, and 48 hours werestatistically lower compared to the ondansetron group (p =0.00, p = 0.00, p = 0.00).Conclusions: In conclusion, intravenous granisetron provedto be more effective than intravenous ondansetron inpreventing nausea and vomiting among patients with ovariancancer undergoing paclitaxel-carboplatin chemotherapy.Keywords: chemotherapy, granisetron, MAT score,ondansetron, ovarian cancer.AbstrakTujuan: Mengetahui efektivitas perbandingan pemberianinjeksi intravena antara granisetron dan ondansetrondalam mencegah mual dan muntah dengan menggunakanMAT pada pasien dengan kanker ovarium yang mendapatkemoterapi dengan regimen paclitaxel-carboplatin.Metode: Penelitian ini merupakan double blind randomizedcontrolled trial dengan kelompok perlakuan diberikangranisetron 1 mg dan kelompok kontrol yang diberikaninjeksi ondansetron 8mg. Kemudian dilakukan penilaianterhadap mual dan muntah dengan menggunakan skorMAT pada 12 jam, 24 jam, dan 48 jam setelah diberikankemoterapi dengan menggunakan Mann-Whitney testkarena distribusi data tidak normal.Hasil: Total sampel pada penelitian ini adalah 60 subjek.Hasil skor MAT pada 12 jam berbeda bermakna dengan skorMAT 24 jam dan skor MAT 48 jam (p= 0,00, p= 0,00. Terdapatperbedaan bermakna secara statistik pada pengaruh terapigranisetron dan ondansetron terhadap skor MAT 12 jam, 24jam, dan 48 jam (p= 0,00, p= 0,00, p= 0,00).Kesimpulan: Pemberian injeksi granisetron intravena lebihefektif mencegah mual dan muntah dengan menggunakanMAT dibandingkan dengan injeksi ondansetron intravenapada pasien dengan kanker ovarium yang mendapatkemoterapi paclitaxel-carboplatin.Kata kunci: kemoterapi, granisetron, kanker ovarium,ondansetron, skor MAT.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":"32 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.32771/inajog.v11i3.1819
Feibyg Lumandung, S. Mongan, B. J. Laihad
Objective: To compare the accuracy of ROMA index andADNEX model in predicting the risk of malignancy in ovariantumour.Methods: This was a prospective analytic study. A total of 37samples were acquired from women of all ages diagnosedwith an ovarian cystic tumour in the Central General HospitalProf. Dr. R. D. Kandou. A CA-125 marker, HE4 marker,menopausal status and ultrasonography (USG) examinationwere obtained, and subsequently compared with the fi nalhistopathological results. The data were analysed by usingthe SPSS statistics software.Results: Thirty-seven women participated in this study. Themean age of participants was 43 years old. The Area UnderCurve (AUC) of the ADNEX was 0.979 with a sensitivity of90.0%, specifi city of 88.2%, negative predictive value of89.8%, and positive predictive value of 80.5%. The AUC ofthe ROMA model was 0.734 with the sensitivity, specifi city,negative predictive value, and positive predictive value of65.0%, 64.7%, 64.8%, and 64.8%, respectively. Both modelsshowed AUC values > 0.50 (p-value < 0.05).Conclusions: The IOTA ADNEX had better accuracy than theROMA model in predicting ovarian epithelial malignancy.The ADNEX model had higher sensitivity and specifi city thanthe ROMA model.Keywords: ADNEX, CA-125, HE4, Ovarian tumour, ROMAAbstrakTujuan: Untuk membandingkan akurasi indeks ROMAdan ADNEX model dalam memprediksi keganasan tumorovariumMetode: Penelitian ini merupakan studi analitik prospektif.Total 37 sampel penelitian didapatkan dari wanita yangdidiagnosa tumor ovarium kistik di RSUP Prof. Dr. R. D.Kandou. CA-125, HE4, status menopause dan pemeriksaanUSG dilakukan, dan dibandingkan dengan hasil histopatologi.Data kemudian dianalisa menggunakan program statistikSPSS.Hasil: Tiga puluh tujuh perempuan yang berpartisipasidalam penelitian ini. Dengan rerata usia 43 tahun. TotalArea Under Curve (AUC) dari IOTA ADNEX adalah 0,979dengan sensitivitas 90,0%, spesifi sitas 88,2%, nilai prediksinegatif 89,8%, dan nilai prediksi positif 80,5%. AUC darimodel ROMA adalah 0,734 dengan sensitivitas, spesifi sitas,nilai prediktif negatif dan nilai predikitif positif 65.0%, 64.7%,64.8%, dan 64.8% berturut-turut. Kedua model menunjukkannilai AUC > 0,50 (nilai p <0,05).Kesimpulan: IOTA ADNEX memiliki akurasi yang lebih baikdibandingkan model ROMA dalam memprediksi keganasanovarium epithelial. ADNEX model memiliki sensitivitas danspesifi sitas lebih tinggi dibandingkan model ROMAKata kunci: ADNEX, CA-125, HE4, ROMA, Tumor Ovarium.
{"title":"Roma Index and Adnex Model: which is more Superior in Predicting Epithelial Ovarian Malignancy?","authors":"Feibyg Lumandung, S. Mongan, B. J. Laihad","doi":"10.32771/inajog.v11i3.1819","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1819","url":null,"abstract":"Objective: To compare the accuracy of ROMA index andADNEX model in predicting the risk of malignancy in ovariantumour.Methods: This was a prospective analytic study. A total of 37samples were acquired from women of all ages diagnosedwith an ovarian cystic tumour in the Central General HospitalProf. Dr. R. D. Kandou. A CA-125 marker, HE4 marker,menopausal status and ultrasonography (USG) examinationwere obtained, and subsequently compared with the fi nalhistopathological results. The data were analysed by usingthe SPSS statistics software.Results: Thirty-seven women participated in this study. Themean age of participants was 43 years old. The Area UnderCurve (AUC) of the ADNEX was 0.979 with a sensitivity of90.0%, specifi city of 88.2%, negative predictive value of89.8%, and positive predictive value of 80.5%. The AUC ofthe ROMA model was 0.734 with the sensitivity, specifi city,negative predictive value, and positive predictive value of65.0%, 64.7%, 64.8%, and 64.8%, respectively. Both modelsshowed AUC values > 0.50 (p-value < 0.05).Conclusions: The IOTA ADNEX had better accuracy than theROMA model in predicting ovarian epithelial malignancy.The ADNEX model had higher sensitivity and specifi city thanthe ROMA model.Keywords: ADNEX, CA-125, HE4, Ovarian tumour, ROMAAbstrakTujuan: Untuk membandingkan akurasi indeks ROMAdan ADNEX model dalam memprediksi keganasan tumorovariumMetode: Penelitian ini merupakan studi analitik prospektif.Total 37 sampel penelitian didapatkan dari wanita yangdidiagnosa tumor ovarium kistik di RSUP Prof. Dr. R. D.Kandou. CA-125, HE4, status menopause dan pemeriksaanUSG dilakukan, dan dibandingkan dengan hasil histopatologi.Data kemudian dianalisa menggunakan program statistikSPSS.Hasil: Tiga puluh tujuh perempuan yang berpartisipasidalam penelitian ini. Dengan rerata usia 43 tahun. TotalArea Under Curve (AUC) dari IOTA ADNEX adalah 0,979dengan sensitivitas 90,0%, spesifi sitas 88,2%, nilai prediksinegatif 89,8%, dan nilai prediksi positif 80,5%. AUC darimodel ROMA adalah 0,734 dengan sensitivitas, spesifi sitas,nilai prediktif negatif dan nilai predikitif positif 65.0%, 64.7%,64.8%, dan 64.8% berturut-turut. Kedua model menunjukkannilai AUC > 0,50 (nilai p <0,05).Kesimpulan: IOTA ADNEX memiliki akurasi yang lebih baikdibandingkan model ROMA dalam memprediksi keganasanovarium epithelial. ADNEX model memiliki sensitivitas danspesifi sitas lebih tinggi dibandingkan model ROMAKata kunci: ADNEX, CA-125, HE4, ROMA, Tumor Ovarium.","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43832243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-21DOI: 10.32771/inajog.v11i3.1867
Anak A. N. Anantasika, Wayan A. Putra, Ida B. P. Adnyana, Wayan Megadhana, Ryan S. Mulyana, Agustinus Darmawan Hariyanto
Objective: To investigate the correlation between cesareansection and oxytocin augmentation in childbirth monitoredwith the Friedman curve compared to the World HealthOrganization (WHO) partographs.Methods: An analytic cross-sectional study was conductedfrom March to May 2021, involving mothers giving birthwhose delivery process was monitored using either theFriedman curve or the WHO partograph (n=28 for eachgroup) at Wangaya Hospital in Denpasar City. The durationof the active phase until delivery, occurrence of cesareansection, and administration of oxytocin augmentationwere assessed using the Friedman curve and the WHOpartograph. The normality of the data was tested using theKolmogorov-Smirnov test, and the Spearman correlationtest was employed to measure the direction and strengthof the correlation.Results: There was no signifi cant difference between thegroups in terms of monitoring the active phase until deliveryusing the Friedman curve compared to the WHO partograph(p=1.000 > 0.05). Maternal monitoring with the Friedmancurve showed a positive correlation with the occurrenceof cesarean section compared to the WHO partograph(r=0.296, p=0.027). Additionally, monitoring childbirth withthe Friedman curve exhibited a positive correlation with theadministration of oxytocin augmentation compared to theWHO partograph (r=0.298, p=0.026).Conclusion: The fi ndings suggest a stronger positivecorrelation between the incidence of cesarean section andthe administration of oxytocin augmentation in childbirthmonitored with the Friedman curve compared to the WHOpartograph.Keywords: cesarean section, Friedman curve, oxytocinaugmentation, WHO partograph.AbstrakTujuan: Untuk menentukan korelasi antara operasi sesardan augmentasi oksitosin pada persalinan yang dipantaudengan kurva Friedman dibandingkan dengan partografOrganisasi Kesehatan Dunia (WHO).Metode: Desain penelitian analitik potong lintangdilakukan pada Maret-Mei 2021, dengan melibatkan ibubersalin yang proses persalinannya dipantau menggunakankurva Friedman atau Partograf WHO (n=28 untuk setiapkelompok) di ruang bersalin di Rumah Sakit Wangaya,Kota Denpasar. Waktu fase aktif hingga kelahiran bayi,persalinan seksio sesarea, dan augmentasi oksitosin dinilaidengan menggunakan kurva Friedman dan Partograf WHO.Uji normalitas dilakukan dengan uji Kolmogorov-Smirnov,dilanjutkan dengan uji korelasi Spearman untuk mengukurarah dan kekuatan korelasi.Hasil: Pemantauan ibu bersalin dengan kurva Friedmandibandingkan dengan Partograf WHO dalam hal faseaktif-persalinan bayi menunjukkan tidak ada perbedaanyang signifi kan di antara kedua kelompok (p = 0,000 >0,05). Pemantauan ibu dengan kurva Friedman berkorelasipositif dengan kejadian bedah sesar dibandingkandengan Partograf WHO (r = 0,296, p = 0,027). Selain itu,pemantauan persalinan dengan kurva Friedman berkorelasipositif dengan pemberian oksitosin dibandingkan denganpartograf WHO (r = 0,298, p = 0,026).Kesimpulan: Terdapat korelasi positif yang lebih tinggiantar
{"title":"Friedman Curve Positively Correlates with Cesarean Section and Oxytocin Augmentation in Active Phase Delivery as Compared to Partograph","authors":"Anak A. N. Anantasika, Wayan A. Putra, Ida B. P. Adnyana, Wayan Megadhana, Ryan S. Mulyana, Agustinus Darmawan Hariyanto","doi":"10.32771/inajog.v11i3.1867","DOIUrl":"https://doi.org/10.32771/inajog.v11i3.1867","url":null,"abstract":"Objective: To investigate the correlation between cesareansection and oxytocin augmentation in childbirth monitoredwith the Friedman curve compared to the World HealthOrganization (WHO) partographs.Methods: An analytic cross-sectional study was conductedfrom March to May 2021, involving mothers giving birthwhose delivery process was monitored using either theFriedman curve or the WHO partograph (n=28 for eachgroup) at Wangaya Hospital in Denpasar City. The durationof the active phase until delivery, occurrence of cesareansection, and administration of oxytocin augmentationwere assessed using the Friedman curve and the WHOpartograph. The normality of the data was tested using theKolmogorov-Smirnov test, and the Spearman correlationtest was employed to measure the direction and strengthof the correlation.Results: There was no signifi cant difference between thegroups in terms of monitoring the active phase until deliveryusing the Friedman curve compared to the WHO partograph(p=1.000 > 0.05). Maternal monitoring with the Friedmancurve showed a positive correlation with the occurrenceof cesarean section compared to the WHO partograph(r=0.296, p=0.027). Additionally, monitoring childbirth withthe Friedman curve exhibited a positive correlation with theadministration of oxytocin augmentation compared to theWHO partograph (r=0.298, p=0.026).Conclusion: The fi ndings suggest a stronger positivecorrelation between the incidence of cesarean section andthe administration of oxytocin augmentation in childbirthmonitored with the Friedman curve compared to the WHOpartograph.Keywords: cesarean section, Friedman curve, oxytocinaugmentation, WHO partograph.AbstrakTujuan: Untuk menentukan korelasi antara operasi sesardan augmentasi oksitosin pada persalinan yang dipantaudengan kurva Friedman dibandingkan dengan partografOrganisasi Kesehatan Dunia (WHO).Metode: Desain penelitian analitik potong lintangdilakukan pada Maret-Mei 2021, dengan melibatkan ibubersalin yang proses persalinannya dipantau menggunakankurva Friedman atau Partograf WHO (n=28 untuk setiapkelompok) di ruang bersalin di Rumah Sakit Wangaya,Kota Denpasar. Waktu fase aktif hingga kelahiran bayi,persalinan seksio sesarea, dan augmentasi oksitosin dinilaidengan menggunakan kurva Friedman dan Partograf WHO.Uji normalitas dilakukan dengan uji Kolmogorov-Smirnov,dilanjutkan dengan uji korelasi Spearman untuk mengukurarah dan kekuatan korelasi.Hasil: Pemantauan ibu bersalin dengan kurva Friedmandibandingkan dengan Partograf WHO dalam hal faseaktif-persalinan bayi menunjukkan tidak ada perbedaanyang signifi kan di antara kedua kelompok (p = 0,000 >0,05). Pemantauan ibu dengan kurva Friedman berkorelasipositif dengan kejadian bedah sesar dibandingkandengan Partograf WHO (r = 0,296, p = 0,027). Selain itu,pemantauan persalinan dengan kurva Friedman berkorelasipositif dengan pemberian oksitosin dibandingkan denganpartograf WHO (r = 0,298, p = 0,026).Kesimpulan: Terdapat korelasi positif yang lebih tinggiantar","PeriodicalId":13477,"journal":{"name":"Indonesian Journal of Obstetrics and Gynecology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49488666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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