Pub Date : 2024-07-15DOI: 10.18231/j.ijceo.2024.066
Anita Misra, Santosh Kumar Sethi, Partha Singh
The objective of this study was to determine whether visual evoked potential (VEP) may be utilized as a screening tool for Ethambutol-induced toxic optic neuropathy (EITON) and whether discontinuing the use of Ethambutol will reverse the signs and symptoms of EITON in patients who are suffering from tuberculosis.Following receipt of authorization from the Institutional Ethics Committee to proceed with the present study, the study officially got underway. The World Health Organization recommended that forty people who had been diagnosed with tuberculosis get ethambutol medication for a period of six months at a dosage of 15-19 milligrams per kilogram of body weight. These patients were inspected both before and after receiving the treatment. Visual function tests and visual evoked potential (VEP) tests were administered to each patient to assess the visual pathway's condition.An irregular VEP pattern was seen in seven patients out of forty individuals, which accounts for 17.5% of the total. Among these seven patients, delayed P100 latency was observed in all seven patients (17.5%), and an aberrant amplitude difference was documented in one patient (2.5%). There were four patients (10%) who were found to have suboptimal visual acuity, and there were three patients (7.5%) who were found to have problems with their colour vision. An association between low visual acuity and increased P100 delay values was discovered in three out of seven cases. This was the case that was investigated. One patient's visual acuity and colour vision had decreased after two months of Ethambutol therapy, while three patients' visual acuity and colour vision had decreased within four to six months of medication. Due to the absence of abnormalities in the fundus, a diagnosis of retrobulbar optic neuritis was made in these four cases, constituting 10% of the total. There was a full reversal of P100 delay in three patients (43%) out of seven and a partial reversal in four (57%) out of seven.Our study demonstrates that even at the recommended doses of ethambutol, a timely and routinely performed pattern VEP can detect a significant proportion of cases of subclinical optic neuritis. Furthermore, it demonstrates that the signs and symptoms of ocular toxicity can be reversed in a significant number of these patients after the cessation of Ethambutol treatment.
{"title":"Visual evoked potential as an early assessment tool in ethambutol-induced toxic optic neuropathy during treatment of tuberculosis","authors":"Anita Misra, Santosh Kumar Sethi, Partha Singh","doi":"10.18231/j.ijceo.2024.066","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.066","url":null,"abstract":"The objective of this study was to determine whether visual evoked potential (VEP) may be utilized as a screening tool for Ethambutol-induced toxic optic neuropathy (EITON) and whether discontinuing the use of Ethambutol will reverse the signs and symptoms of EITON in patients who are suffering from tuberculosis.Following receipt of authorization from the Institutional Ethics Committee to proceed with the present study, the study officially got underway. The World Health Organization recommended that forty people who had been diagnosed with tuberculosis get ethambutol medication for a period of six months at a dosage of 15-19 milligrams per kilogram of body weight. These patients were inspected both before and after receiving the treatment. Visual function tests and visual evoked potential (VEP) tests were administered to each patient to assess the visual pathway's condition.An irregular VEP pattern was seen in seven patients out of forty individuals, which accounts for 17.5% of the total. Among these seven patients, delayed P100 latency was observed in all seven patients (17.5%), and an aberrant amplitude difference was documented in one patient (2.5%). There were four patients (10%) who were found to have suboptimal visual acuity, and there were three patients (7.5%) who were found to have problems with their colour vision. An association between low visual acuity and increased P100 delay values was discovered in three out of seven cases. This was the case that was investigated. One patient's visual acuity and colour vision had decreased after two months of Ethambutol therapy, while three patients' visual acuity and colour vision had decreased within four to six months of medication. Due to the absence of abnormalities in the fundus, a diagnosis of retrobulbar optic neuritis was made in these four cases, constituting 10% of the total. There was a full reversal of P100 delay in three patients (43%) out of seven and a partial reversal in four (57%) out of seven.Our study demonstrates that even at the recommended doses of ethambutol, a timely and routinely performed pattern VEP can detect a significant proportion of cases of subclinical optic neuritis. Furthermore, it demonstrates that the signs and symptoms of ocular toxicity can be reversed in a significant number of these patients after the cessation of Ethambutol treatment.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":"47 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141648641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To study ocular surface and tear flim abnormalities in patients undergoing [PHACO] and [SICS]. [DED] is a disease of either tears or the ocular surface which leads to visual disturbance. SICS resulting in corneal hyposensitivity and reduction in reflex secretion and wound healing. PHACO is a contemporary cataract surgery in which the eyes internal lens is emulsified and aspirated from the eye using an ultrasonic handpiece.A Hospital based prospective study involved 100 patients aged 40-65 years.100 patients were subdivided into 2 groups, 50 members in each group. The observation of TBUT before surgery and after 1,3,6 months post-surgery were carried out in both group of patients.In this study 100 patients were subdivided into 2 groups, 50 members in each group as follows Group 1-50 patients scheduled for SICS with PCIOL implantation, Group 2-50 patients scheduled for PHACO with PCIOL implantation. Preoperatively the mean Schrimer value was 13.70 and 13.40 in patients underwent SICS and PHACO respectively. At postoperative 1 week, 89.1% of the group had grade 2 dry eye compared to 92.9% in the SICS group [p 0.0001].Individuals with SICS had a higher prevalence and severity of dry eyes than those with PHACO.
{"title":"Comparative study of tear flim abnormalities and dry eye conditions in ocular surface following phacoemulsification and small incision cataract surgery [SICS] A hospital based prospective study","authors":"Shamili Kannappan, Jeyaprakash, Ezhilvendhan, Jashaswini Nanda, Sozhama Devi","doi":"10.18231/j.ijceo.2024.043","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.043","url":null,"abstract":"To study ocular surface and tear flim abnormalities in patients undergoing [PHACO] and [SICS]. [DED] is a disease of either tears or the ocular surface which leads to visual disturbance. SICS resulting in corneal hyposensitivity and reduction in reflex secretion and wound healing. PHACO is a contemporary cataract surgery in which the eyes internal lens is emulsified and aspirated from the eye using an ultrasonic handpiece.A Hospital based prospective study involved 100 patients aged 40-65 years.100 patients were subdivided into 2 groups, 50 members in each group. The observation of TBUT before surgery and after 1,3,6 months post-surgery were carried out in both group of patients.In this study 100 patients were subdivided into 2 groups, 50 members in each group as follows Group 1-50 patients scheduled for SICS with PCIOL implantation, Group 2-50 patients scheduled for PHACO with PCIOL implantation. Preoperatively the mean Schrimer value was 13.70 and 13.40 in patients underwent SICS and PHACO respectively. At postoperative 1 week, 89.1% of the group had grade 2 dry eye compared to 92.9% in the SICS group [p 0.0001].Individuals with SICS had a higher prevalence and severity of dry eyes than those with PHACO.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":"37 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.18231/j.ijceo.2024.058
Faiza Ibrahim, S. Thulaseedharan, Laly Thekkemeppilly Unnikrishnan, Sabna Sasidharan
Myopia is a leading cause of visual impairment. This study aims at determining the changes in corneal asphericity, central corneal radius of curvature, anterior chamber depth, lens thickness, vitreous chamber depth, and axial length with increasing myopia. Spherical equivalent refractive error of each myopic eye was determined and grouped into three, according to increasing powers of myopia. Corneal asphericity (Q value) and central corneal radius of curvature were determined using corneal topography. Anterior chamber depth, lens thickness, vitreous chamber depth, and axial length were determined using Ascan. Changes with increasing myopia was assessed. Among 80 myopic eyes of age group 6 to 40 years, more patients were between 21 to 30 years. 60% of them were males. 60% were low myopes (<-3D), 32% were moderate myopes (-3D to -6D) and 8% were high myopes (>-6D). Mean Q values were -0.49±0.09, -0.39±0.04 and -0.28 ±0.04 for low, moderate and high myopes respectively. Mean values of apical radius of curvature of cornea were 7.66±0.07, 7.53±0.08 and 7.35±0.07 for low, moderate and high myopes respectively. Mean values of anterior chamber depth were 3.19±0.09, 3.32±0.09, 3.88±0.08; vitreous chamber depth were 19.82±0.67, 21.66±0.24, 22.66±0.45 and axial length were 23.01±0.76, 24.98±0.32,26.54±0.51 for low, moderate and high myopes respectively. A statistically significant positive correlation of increasing degrees of myopia was observed with Q value, anterior chamber depth, vitreous chamber depth and axial length; and a statistically significant negative correlation with the apical radius of curvature. In myopic eyes, a statistically significant relation exists between corneal asphericity and spherical equivalent refractive error such that, there is a tendency for the cornea to flatten less rapidly in the periphery with increasing myopia and eyes with higher levels of myopia have steeper central corneal curvature, with deep anterior and vitreous chamber and greater axial length.
{"title":"A cross-sectional study of corneal topography and ocular parameters in patients with myopia","authors":"Faiza Ibrahim, S. Thulaseedharan, Laly Thekkemeppilly Unnikrishnan, Sabna Sasidharan","doi":"10.18231/j.ijceo.2024.058","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.058","url":null,"abstract":"Myopia is a leading cause of visual impairment. This study aims at determining the changes in corneal asphericity, central corneal radius of curvature, anterior chamber depth, lens thickness, vitreous chamber depth, and axial length with increasing myopia. Spherical equivalent refractive error of each myopic eye was determined and grouped into three, according to increasing powers of myopia. Corneal asphericity (Q value) and central corneal radius of curvature were determined using corneal topography. Anterior chamber depth, lens thickness, vitreous chamber depth, and axial length were determined using Ascan. Changes with increasing myopia was assessed. Among 80 myopic eyes of age group 6 to 40 years, more patients were between 21 to 30 years. 60% of them were males. 60% were low myopes (<-3D), 32% were moderate myopes (-3D to -6D) and 8% were high myopes (>-6D). Mean Q values were -0.49±0.09, -0.39±0.04 and -0.28 ±0.04 for low, moderate and high myopes respectively. Mean values of apical radius of curvature of cornea were 7.66±0.07, 7.53±0.08 and 7.35±0.07 for low, moderate and high myopes respectively. Mean values of anterior chamber depth were 3.19±0.09, 3.32±0.09, 3.88±0.08; vitreous chamber depth were 19.82±0.67, 21.66±0.24, 22.66±0.45 and axial length were 23.01±0.76, 24.98±0.32,26.54±0.51 for low, moderate and high myopes respectively. A statistically significant positive correlation of increasing degrees of myopia was observed with Q value, anterior chamber depth, vitreous chamber depth and axial length; and a statistically significant negative correlation with the apical radius of curvature. In myopic eyes, a statistically significant relation exists between corneal asphericity and spherical equivalent refractive error such that, there is a tendency for the cornea to flatten less rapidly in the periphery with increasing myopia and eyes with higher levels of myopia have steeper central corneal curvature, with deep anterior and vitreous chamber and greater axial length.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.003
Arvind Kumar Patel, P. Chandra, N. Sachan, Neha Singh
Allergic disorder is a serious issue affecting 40% of the population. The most well-known visual illness in clinical practise is undoubtedly visual sensitivity. The impact of numerous variables, including genetics and pollution, is taken into account by experts. Therefore, this review is intends to provide the detailed description related to pathophysiology and managements of allergic conjunctivitis.The study was performed by literature survey of original research articles published in Pubmed, Science direct, Web of Science, Scopus and Google etc.The two primary types of allergic conjunctivitis are perennial allergic conjunctivitis (PAC) and seasonal allergic conjunctivitis (SAC). The common effects of SAC and PAC are shivers, weeping, mucus production, and redness; nonetheless, these structures do not impair vision. However, vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are the most alarming types of visual allergic conjunctivitis, which impact the cornea and can impair vision if not properly recognised and treated. Allergic conjunctivitis symptoms include itchy, stinging red eyes and yellow pus during sleep. The major objectives of treatment for allergic conjunctivitis are to lessen and manage symptoms and raise quality of life. This involves minimising itchiness, as well as redness, tears, edoema of the conjunctiva or the eyelids, and other related disorders. Breaking the pattern of inflammation and reducing it are additional therapy objectives for patients with chronic allergen exposure and persistent illness. Mast cell stabilisers, corticosteroids, antihistamines, NSAIDs, dual-acting antiallergics, anti-leukotrienes, anti-IgE, and some other drugs are used to treat allergic conjunctivitis.There are the different types of allergic conjunctivitis among which the more prevalence types of allergic conjunctivitis are SAC and PAC while the more severe types are VKC and AKC. There are different types of medicines available for treatment of allergic conjunctivitis.
过敏性疾病是一个严重的问题，影响着 40% 的人口。在临床实践中，最著名的视觉疾病无疑是视觉敏感症。专家们考虑到了遗传和污染等众多变量的影响。因此，本综述旨在提供有关过敏性结膜炎的病理生理学和治疗方法的详细描述。本研究通过对发表在 Pubmed、Science direct、Web of Science、Scopus 和 Google 等网站上的原始研究文章进行文献调查来完成。常年性过敏性结膜炎（PAC）和季节性过敏性结膜炎（SAC）的常见症状是哆嗦、流泪、分泌粘液和发红，但这些症状不会影响视力。然而，春季角膜结膜炎（VKC）和特应性角膜结膜炎（AKC）是最令人担忧的视觉过敏性结膜炎类型，它们会影响角膜，如果没有得到正确的认识和治疗，会损害视力。过敏性结膜炎的症状包括眼睛发痒、刺痛、发红以及睡觉时流黄色脓液。治疗过敏性结膜炎的主要目的是减轻和控制症状，提高生活质量。这包括尽量减轻瘙痒、发红、流泪、结膜或眼睑水肿以及其他相关病症。对于长期接触过敏原和久治不愈的患者来说，打破炎症模式和减轻炎症是额外的治疗目标。治疗过敏性结膜炎的药物包括肥大细胞稳定剂、皮质类固醇、抗组胺药、非甾体抗炎药、双效抗过敏药、抗白三烯类药物、抗 IgE 以及其他一些药物。治疗过敏性结膜炎的药物有很多种。
{"title":"A review on pathophysiology and managements of allergic conjunctivitis","authors":"Arvind Kumar Patel, P. Chandra, N. Sachan, Neha Singh","doi":"10.18231/j.ijceo.2024.003","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.003","url":null,"abstract":"Allergic disorder is a serious issue affecting 40% of the population. The most well-known visual illness in clinical practise is undoubtedly visual sensitivity. The impact of numerous variables, including genetics and pollution, is taken into account by experts. Therefore, this review is intends to provide the detailed description related to pathophysiology and managements of allergic conjunctivitis.The study was performed by literature survey of original research articles published in Pubmed, Science direct, Web of Science, Scopus and Google etc.The two primary types of allergic conjunctivitis are perennial allergic conjunctivitis (PAC) and seasonal allergic conjunctivitis (SAC). The common effects of SAC and PAC are shivers, weeping, mucus production, and redness; nonetheless, these structures do not impair vision. However, vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are the most alarming types of visual allergic conjunctivitis, which impact the cornea and can impair vision if not properly recognised and treated. Allergic conjunctivitis symptoms include itchy, stinging red eyes and yellow pus during sleep. The major objectives of treatment for allergic conjunctivitis are to lessen and manage symptoms and raise quality of life. This involves minimising itchiness, as well as redness, tears, edoema of the conjunctiva or the eyelids, and other related disorders. Breaking the pattern of inflammation and reducing it are additional therapy objectives for patients with chronic allergen exposure and persistent illness. Mast cell stabilisers, corticosteroids, antihistamines, NSAIDs, dual-acting antiallergics, anti-leukotrienes, anti-IgE, and some other drugs are used to treat allergic conjunctivitis.There are the different types of allergic conjunctivitis among which the more prevalence types of allergic conjunctivitis are SAC and PAC while the more severe types are VKC and AKC. There are different types of medicines available for treatment of allergic conjunctivitis.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.007
Tran-Anh Le, Thang T Tran, C. D. Hoang, Loid B. Cao
: To describe the pattern of eye disease in a provincial ophthalmic hospital in Viet Nam.: We retrospectively analyzed records of 1735 patients with disorders of the eye and adnexa admitted to the Nghe an Eye Hospital, Nghe an province, Vietnam between January 2022 and May 2023. : The mean age of patients was 60.4± 16.6 years old and 54.7% were females. The most common cause of hospitalizations were disorders of sclera, cornea, iris, and ciliary body (55.0% of cases) followed by glaucoma (29.2%) and disorders of the eyelid, lacrimal system, and orbit (15.8%). Keratitis was the most common ocular morbidity (40.1%), followed by glaucoma (29.20%), and iridocyclitis (13.5%). The average highest age was in patients with disorders of the eyelid, lacrimal system, and orbit (67.3 ± 13.4 years) followed by those with glaucoma (62.2 ± 13.8 years) and lesions on the sclera, cornea, iris, and ciliary body (57.5 ± 17.9 years). The female/male rate among those with disorders of eyelid, lacrimal system and orbit was higher than among cases with the other disorders (1.6/1 vs 1.1/1, p = 0.008). The mean length of hospital stay was 8.6 days and patients with disorders of sclera and cornea had the most extended average length of hospital stay (more than 10 days). Keratitis, glaucoma, and iridocyclitis were the major ocular conditions seen in this study. Prevention of keratitis should decrease both morbidity and health expenditure for eye disease.
{"title":"The pattern of eye disease in a provincial ophthalmic hospital of Viet Nam","authors":"Tran-Anh Le, Thang T Tran, C. D. Hoang, Loid B. Cao","doi":"10.18231/j.ijceo.2024.007","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.007","url":null,"abstract":": To describe the pattern of eye disease in a provincial ophthalmic hospital in Viet Nam.: We retrospectively analyzed records of 1735 patients with disorders of the eye and adnexa admitted to the Nghe an Eye Hospital, Nghe an province, Vietnam between January 2022 and May 2023. : The mean age of patients was 60.4± 16.6 years old and 54.7% were females. The most common cause of hospitalizations were disorders of sclera, cornea, iris, and ciliary body (55.0% of cases) followed by glaucoma (29.2%) and disorders of the eyelid, lacrimal system, and orbit (15.8%). Keratitis was the most common ocular morbidity (40.1%), followed by glaucoma (29.20%), and iridocyclitis (13.5%). The average highest age was in patients with disorders of the eyelid, lacrimal system, and orbit (67.3 ± 13.4 years) followed by those with glaucoma (62.2 ± 13.8 years) and lesions on the sclera, cornea, iris, and ciliary body (57.5 ± 17.9 years). The female/male rate among those with disorders of eyelid, lacrimal system and orbit was higher than among cases with the other disorders (1.6/1 vs 1.1/1, p = 0.008). The mean length of hospital stay was 8.6 days and patients with disorders of sclera and cornea had the most extended average length of hospital stay (more than 10 days). Keratitis, glaucoma, and iridocyclitis were the major ocular conditions seen in this study. Prevention of keratitis should decrease both morbidity and health expenditure for eye disease.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.031
Yamini Rawate, Keshav Kumar Hota, Somya Dulani
The aim of this study is to evaluate the various factors affecting the visual outcome of paediatric cataract surgery. Paediatric cataract is a huge problem of the world specially for developing and poor countries. Without treatment cataract can damage connection between brain and eye. So importance of early diagnosis and treatment can prevent permanent vision loss in children.Cataract in children can appear in variety of forms, each presenting in differencing in different way depending on the time. Sometime cataract associated with other ocular disease like coloboma, nystagmus, microphthalmos. These conditions are associated with poor prognosis. So proper visual rehabilitation of neuro- ophthalmic axis is crucial for good visual prognosis. All patients from 2 - 14 years of age who underwent cataract surgery in Department of Ophthalmology at BRLSABVMM College Rajnandgaon during 1- year period were included in the study. Detail history of patient, preoperative examination, ocular and systemic co-morbidity, intraoperative complications and post-operative outcome were documented and analysed. 25 patients underwent cataract surgery during this period.16 were male (64%) and 9 females (36%). Most common presenting symptom is diminution of vision in some cases nystagmus and strabismus also present. In some patient there is history of trauma also present. There was significant improvement in best corrected visual acuity following surgery in approx. 70% of patients. Visual axis opacification is most common complication after that fibrin reaction is other complication.: Improvement in vision in post operative paediatric cataract surgery due to early detection by parents and raise awareness by health workers of rural and urban area. Good visual outcome is depended on good infrastructure for operation theatre, advance microscope with instrument, advance cataract surgery with posterior capsulotomy and anterior vitrectomy, post-operative management and visual rehabilitation.
{"title":"Factors affecting the visual outcome of paediatric cataract surgery: A hospital based prospective study in tertiary eye care","authors":"Yamini Rawate, Keshav Kumar Hota, Somya Dulani","doi":"10.18231/j.ijceo.2024.031","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.031","url":null,"abstract":"The aim of this study is to evaluate the various factors affecting the visual outcome of paediatric cataract surgery. Paediatric cataract is a huge problem of the world specially for developing and poor countries. Without treatment cataract can damage connection between brain and eye. So importance of early diagnosis and treatment can prevent permanent vision loss in children.Cataract in children can appear in variety of forms, each presenting in differencing in different way depending on the time. Sometime cataract associated with other ocular disease like coloboma, nystagmus, microphthalmos. These conditions are associated with poor prognosis. So proper visual rehabilitation of neuro- ophthalmic axis is crucial for good visual prognosis. All patients from 2 - 14 years of age who underwent cataract surgery in Department of Ophthalmology at BRLSABVMM College Rajnandgaon during 1- year period were included in the study. Detail history of patient, preoperative examination, ocular and systemic co-morbidity, intraoperative complications and post-operative outcome were documented and analysed. 25 patients underwent cataract surgery during this period.16 were male (64%) and 9 females (36%). Most common presenting symptom is diminution of vision in some cases nystagmus and strabismus also present. In some patient there is history of trauma also present. There was significant improvement in best corrected visual acuity following surgery in approx. 70% of patients. Visual axis opacification is most common complication after that fibrin reaction is other complication.: Improvement in vision in post operative paediatric cataract surgery due to early detection by parents and raise awareness by health workers of rural and urban area. Good visual outcome is depended on good infrastructure for operation theatre, advance microscope with instrument, advance cataract surgery with posterior capsulotomy and anterior vitrectomy, post-operative management and visual rehabilitation.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.008
Sameera Iqbal, Manoj Soman, Indu J. Nair, Ravi R V, Unnikrishnan Nair
To evaluate the effectiveness and safety profile of Ranibizumab Biosimilar in Macular Neovascularisation and compare outcomes with patent Ranibizumab.A retrospective analysis during the period 2017-2020 was conducted at a tertiary eye care centre in South Kerala on patients with wet AMD who had received Razumab, a biosimilar of Ranibizumab as a loading dose followed by PRN schedule. This was compared to a similar data obtained from patented Ranibizumab (Lucentis) during the same period. Endpoints analyzed included improvement in BCVA, proportion of patients with persistent IRF/SRF and complications at 1 year. Of 164 eyes analyzed 76 eyes received Razumab and 88 eyes received Lucentis with 32% and 50% males in each group. After the loading dose both drugs showed similar efficacy and the final vision (median logmar; 0.24 vs 0.17; p 0.189), presence of residual CME (31.6% vs 18.2%; p 0.469) and SRF (57.9% vs 61.9%; p 0.796) were similar in both groups at 12 months. The mean number of injections was 8 in the Razumab group comparable to Lucentis (6.4). Acceptability and less drop outs were seen in Razumab patients compared to Lucentis. Though some eyes developed mild uveitis (4.3%) with one of the initial batches of Razumab, it was not evidenced later. No other safety concerns or side effects were reported with the biosimilar.The Biosimilar Razumab is as effective as the patent molecule in reducing macular fluid and improving visual acuity in patients with macular neovascularization over 1 year on a PRN schedule. Being cheaper it is a safe alternative for patients who often need long term management.
南喀拉拉邦的一家三级眼科医疗中心在 2017-2020 年期间对湿性 AMD 患者进行了一项回顾性分析，这些患者接受了雷珠单抗生物仿制药 Razumab（一种雷珠单抗的生物仿制药）的负荷剂量治疗，然后按 PRN 计划进行治疗。这与同期获得专利的雷珠单抗（Lucentis）的类似数据进行了比较。分析的终点包括BCVA的改善、持续IRF/SRF患者的比例以及1年后的并发症。在分析的164只眼睛中，76只眼睛接受了雷珠单抗治疗，88只眼睛接受了Lucentis治疗，两组中男性比例分别为32%和50%。负荷剂量后，两种药物显示出相似的疗效，12 个月时，两组的最终视力（中位数 logmar；0.24 vs 0.17；p 0.189）、残留 CME（31.6% vs 18.2%；p 0.469）和 SRF（57.9% vs 61.9%；p 0.796）相似。雷珠单抗组的平均注射次数为 8 次，与卢森替斯组（6.4 次）相当。与卢森替斯相比，雷珠单抗患者的接受度更高，辍药率更低。虽然在使用雷珠单抗的最初批次中，有些眼睛出现了轻度葡萄膜炎（4.3%），但后来没有再出现这种情况。生物仿制药 Razumab 在减少黄斑积液和改善黄斑新生血管患者视力方面的疗效与专利分子相同，可按 PRN 计划使用一年。生物仿制药雷珠单抗的价格更低，对于需要长期治疗的患者来说是一种安全的选择。
{"title":"Does ranibizumab biosimilars fare as well in macular neovascularisation?","authors":"Sameera Iqbal, Manoj Soman, Indu J. Nair, Ravi R V, Unnikrishnan Nair","doi":"10.18231/j.ijceo.2024.008","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.008","url":null,"abstract":"To evaluate the effectiveness and safety profile of Ranibizumab Biosimilar in Macular Neovascularisation and compare outcomes with patent Ranibizumab.A retrospective analysis during the period 2017-2020 was conducted at a tertiary eye care centre in South Kerala on patients with wet AMD who had received Razumab, a biosimilar of Ranibizumab as a loading dose followed by PRN schedule. This was compared to a similar data obtained from patented Ranibizumab (Lucentis) during the same period. Endpoints analyzed included improvement in BCVA, proportion of patients with persistent IRF/SRF and complications at 1 year. Of 164 eyes analyzed 76 eyes received Razumab and 88 eyes received Lucentis with 32% and 50% males in each group. After the loading dose both drugs showed similar efficacy and the final vision (median logmar; 0.24 vs 0.17; p 0.189), presence of residual CME (31.6% vs 18.2%; p 0.469) and SRF (57.9% vs 61.9%; p 0.796) were similar in both groups at 12 months. The mean number of injections was 8 in the Razumab group comparable to Lucentis (6.4). Acceptability and less drop outs were seen in Razumab patients compared to Lucentis. Though some eyes developed mild uveitis (4.3%) with one of the initial batches of Razumab, it was not evidenced later. No other safety concerns or side effects were reported with the biosimilar.The Biosimilar Razumab is as effective as the patent molecule in reducing macular fluid and improving visual acuity in patients with macular neovascularization over 1 year on a PRN schedule. Being cheaper it is a safe alternative for patients who often need long term management.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.019
Khizer Hussain Afroze M, Shreyas Bhaskar, A. R. Vishal, Tulsi Raju V, Shakthi Vel P
To determine the attachment of optic strut relative to anterior clinoid process. To categorize optic strut into the sulcal, pre-sulcal, post-sulcal. To determine the association between laterality and optic strut attachment pattern. The study was conducted on 100 normal CT scans of Head and Para nasal sinus. Optic strut was classified as pre-sulcal, sulcal, post-sulcal, and asymmetric in relation to the prechiasmatic sulcus. Optic strut location was determined as anterior, middle and posterior with respect to anterior clinoid process. The optic strut was found to be anterior in 28% specimen, middle in 57% specimen and posterior in 15% specimen. The optic strut was pre-sulcal in 31% specimens, sulcal in 50%, post-sulcal in 16%. The above were observed bilaterally, and 3% were unilateral. Anatomical variations in the optic strut are significant in planning for anterior clinoidectomy and optic-canal decompression.
{"title":"Tomographical study of optic strut location and its significance","authors":"Khizer Hussain Afroze M, Shreyas Bhaskar, A. R. Vishal, Tulsi Raju V, Shakthi Vel P","doi":"10.18231/j.ijceo.2024.019","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.019","url":null,"abstract":"To determine the attachment of optic strut relative to anterior clinoid process. To categorize optic strut into the sulcal, pre-sulcal, post-sulcal. To determine the association between laterality and optic strut attachment pattern. The study was conducted on 100 normal CT scans of Head and Para nasal sinus. Optic strut was classified as pre-sulcal, sulcal, post-sulcal, and asymmetric in relation to the prechiasmatic sulcus. Optic strut location was determined as anterior, middle and posterior with respect to anterior clinoid process. The optic strut was found to be anterior in 28% specimen, middle in 57% specimen and posterior in 15% specimen. The optic strut was pre-sulcal in 31% specimens, sulcal in 50%, post-sulcal in 16%. The above were observed bilaterally, and 3% were unilateral. Anatomical variations in the optic strut are significant in planning for anterior clinoidectomy and optic-canal decompression.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 95","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140392350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.027
Manmohan Gupta, J. M. Manoher, Anil Chauhan, Vijay Singh Mangawa, Gaurav Joshi, Devanshi Halwai
: The aim of the study was to evaluate whether serum lipids levels are associated with incidence and type of age related cataract (ARC).: This was a analytical observational study conducted at Department of Ophthalmology of S.P. Medical College and Associated Group of Hospitals, Bikaner, Rajasthan, India. A random sample size of 200 subjects who met the inclusion criteria was recruited.: Data were analyzed and statistically evaluated using SPSS-PC-25 version.In the present study we found that mean age for control group was 50.84 years and 60.91 years for case group. In control group 69% male patients were seen while in case group 53% male patients were present. The mean Serum CHO level was found to be 204.66 ± 50.76 mg/dl in control subjects and it was found to be 226.63 ± 59.63 mg/dl in the subjects with age-related cataract (ARC). The mean Serum TG level was found to be 113.70 ± 59.92 mg/dl in control subjects and it was found to be 149.35 ± 68.12mg/dl in the subjects with age-related cataract (ARC). The mean Serum HDL level was found to be 58.65 ± 15.25 mg/dl in control subjects and it was found to be 53.12 ± 11.28 mg/dl in the subjects with age-related cataract (ARC). Our study found association between serum lipid profiles with age related cataract in the population. Our findings indicate a need for health promotional activities and health care access for controlling this modifiable factor among the ageing population of the country.
{"title":"Association of serum lipid level with age related cataract in north western Rajasthan","authors":"Manmohan Gupta, J. M. Manoher, Anil Chauhan, Vijay Singh Mangawa, Gaurav Joshi, Devanshi Halwai","doi":"10.18231/j.ijceo.2024.027","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.027","url":null,"abstract":": The aim of the study was to evaluate whether serum lipids levels are associated with incidence and type of age related cataract (ARC).: This was a analytical observational study conducted at Department of Ophthalmology of S.P. Medical College and Associated Group of Hospitals, Bikaner, Rajasthan, India. A random sample size of 200 subjects who met the inclusion criteria was recruited.: Data were analyzed and statistically evaluated using SPSS-PC-25 version.In the present study we found that mean age for control group was 50.84 years and 60.91 years for case group. In control group 69% male patients were seen while in case group 53% male patients were present. The mean Serum CHO level was found to be 204.66 ± 50.76 mg/dl in control subjects and it was found to be 226.63 ± 59.63 mg/dl in the subjects with age-related cataract (ARC). The mean Serum TG level was found to be 113.70 ± 59.92 mg/dl in control subjects and it was found to be 149.35 ± 68.12mg/dl in the subjects with age-related cataract (ARC). The mean Serum HDL level was found to be 58.65 ± 15.25 mg/dl in control subjects and it was found to be 53.12 ± 11.28 mg/dl in the subjects with age-related cataract (ARC). Our study found association between serum lipid profiles with age related cataract in the population. Our findings indicate a need for health promotional activities and health care access for controlling this modifiable factor among the ageing population of the country.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15DOI: 10.18231/j.ijceo.2024.010
Sultan Alrashidi
Measuring age-matched normative corneal thickness (CT) values in the center and peripheral regions can be useful in clinical practice. To determine the influence of age and gender on the central, paracentral and mid-peripheral corneal pachymetry profile in normal eyes using spectral domain optical coherence tomography (SD-OCT); and to estimate the average regional CT profiles across all the age groups. Five ninety-six healthy eyes of 298 subjects aged between 10 and 98 years were evaluated using REVO FC anterior segment SD-OCT with predefined concentric corneal ring-shaped zones. CT was calculated in 17 sectors within a central 7-mm circle. Central zone CT (CCT: 2mm), paracentral (PCT: 2 to 5-mm), and midperipheral (MPCT: 5 to 7-mm) in the superior, superior temporal, temporal, inferior temporal, inferior, inferior nasal, nasal and superior nasal cornea; minimum, maximum, median thickness within the 7-mm diameter area were recorded. The mean CT in corresponding zone was compared between genders and correlations with age were evaluated. The distribution of CCT was 537.9±38µm with no significant difference between right and left eyes, or between males and females CCT. No significant difference noted between male and female participants with respect to age, and no interocular asymmetry in CT was identified either in paracentral or midperipheral zones (17 sectors). The PCT was 1.6% to 5.2% thicker whereas the MPCT sector was 2.3% to 11.4% thicker than the CCT, with the paracentral and midperipheral sectors’ superior and superior nasal zones were the thickest zones in the normal population. The mean paracentral inferior temporal (537.9±38.0) and temporal (538.7±37.2) zones’ CT were similar to mean CCT-2mm (537.7±36.3). CT varied with age in the seven groups of both genders, specifically in the paracentral and mid-peripheral zones. CT decreases, but its dependence on age is weaker. The CT increased gradually from the center to midperipheral ring with the superior and superior nasal regions had the thickest CTs, while the thinnest points are located primarily in the temporal and inferior temporal cornea. With the help of SD-OCT, this is the first study establishes the normative central, paracentral, mid-peripheral, and minimum CT data, which differ significantly from Saudi Arabians in location and magnitude. Based on the results, decisions regarding refractive surgery and corneal diagnosis can be made.
{"title":"A cross-sectional study to compare the regional corneal thickness profiles in various age groups of Saudi population using 7 mm wide optical coherence tomography scans","authors":"Sultan Alrashidi","doi":"10.18231/j.ijceo.2024.010","DOIUrl":"https://doi.org/10.18231/j.ijceo.2024.010","url":null,"abstract":"Measuring age-matched normative corneal thickness (CT) values in the center and peripheral regions can be useful in clinical practice. To determine the influence of age and gender on the central, paracentral and mid-peripheral corneal pachymetry profile in normal eyes using spectral domain optical coherence tomography (SD-OCT); and to estimate the average regional CT profiles across all the age groups. Five ninety-six healthy eyes of 298 subjects aged between 10 and 98 years were evaluated using REVO FC anterior segment SD-OCT with predefined concentric corneal ring-shaped zones. CT was calculated in 17 sectors within a central 7-mm circle. Central zone CT (CCT: 2mm), paracentral (PCT: 2 to 5-mm), and midperipheral (MPCT: 5 to 7-mm) in the superior, superior temporal, temporal, inferior temporal, inferior, inferior nasal, nasal and superior nasal cornea; minimum, maximum, median thickness within the 7-mm diameter area were recorded. The mean CT in corresponding zone was compared between genders and correlations with age were evaluated. The distribution of CCT was 537.9±38µm with no significant difference between right and left eyes, or between males and females CCT. No significant difference noted between male and female participants with respect to age, and no interocular asymmetry in CT was identified either in paracentral or midperipheral zones (17 sectors). The PCT was 1.6% to 5.2% thicker whereas the MPCT sector was 2.3% to 11.4% thicker than the CCT, with the paracentral and midperipheral sectors’ superior and superior nasal zones were the thickest zones in the normal population. The mean paracentral inferior temporal (537.9±38.0) and temporal (538.7±37.2) zones’ CT were similar to mean CCT-2mm (537.7±36.3). CT varied with age in the seven groups of both genders, specifically in the paracentral and mid-peripheral zones. CT decreases, but its dependence on age is weaker. The CT increased gradually from the center to midperipheral ring with the superior and superior nasal regions had the thickest CTs, while the thinnest points are located primarily in the temporal and inferior temporal cornea. With the help of SD-OCT, this is the first study establishes the normative central, paracentral, mid-peripheral, and minimum CT data, which differ significantly from Saudi Arabians in location and magnitude. Based on the results, decisions regarding refractive surgery and corneal diagnosis can be made.","PeriodicalId":13485,"journal":{"name":"Indian Journal of Clinical and Experimental Ophthalmology","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140391638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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