Introduction: Multiple primaries have been reported in patients with breast cancer in the range of 4.1% to 16.4%. This report followed the standard Surgical Case Report (SCARE) and discussed two histologically distinct breast cancer malignancies. This paper also explored the risk factor, pathogenesis, treatment, and prognosis of multiple primary malignancies in the same organs, especially in the breasts.Case Presentation: The patient was a 45-year-old woman with a lump in the left and right breasts for five years. The patient claimed that the lump was enlarged and painless. The tumor size of the left breast was 3 x 2 x 3 cm, the right breast was 4 x 2 x 4 cm, and the patient had no enlargement of lymph nodes. The patient underwent a biopsy examination of the left breast showing invasive ductal carcinoma NST (No Special Type) 3rd grade with LV1 (+). The biopsy examination of the right breast showed malignant phyllodes tumor. Thus, the patient must undergo chemotherapy and mastectomy as definitive therapy. The patient has already completed the treatment and is currently under evaluation.Conclusion: This report looked for the rare case of double primary malignancies in the breasts. It highlighted double primary cancers starting to increase these days but in a particular way because it happens in the same organ, the breasts. However, medical literature rarely presented a synchronous malignancy case, prompting the publishing of this case. With improved cancer treatment and more prolonged survival, the number of patients with double cancers is increasing.
{"title":"A Case Report of Double Primer Cancer: Malignant Phyllodes Tumor and Invasive Ductal Carcinoma","authors":"Lauraine Wijayaningtyas Sinuraya, K. Y. Yarso","doi":"10.33371/ijoc.v16i4.934","DOIUrl":"https://doi.org/10.33371/ijoc.v16i4.934","url":null,"abstract":"Introduction: Multiple primaries have been reported in patients with breast cancer in the range of 4.1% to 16.4%. This report followed the standard Surgical Case Report (SCARE) and discussed two histologically distinct breast cancer malignancies. This paper also explored the risk factor, pathogenesis, treatment, and prognosis of multiple primary malignancies in the same organs, especially in the breasts.Case Presentation: The patient was a 45-year-old woman with a lump in the left and right breasts for five years. The patient claimed that the lump was enlarged and painless. The tumor size of the left breast was 3 x 2 x 3 cm, the right breast was 4 x 2 x 4 cm, and the patient had no enlargement of lymph nodes. The patient underwent a biopsy examination of the left breast showing invasive ductal carcinoma NST (No Special Type) 3rd grade with LV1 (+). The biopsy examination of the right breast showed malignant phyllodes tumor. Thus, the patient must undergo chemotherapy and mastectomy as definitive therapy. The patient has already completed the treatment and is currently under evaluation.Conclusion: This report looked for the rare case of double primary malignancies in the breasts. It highlighted double primary cancers starting to increase these days but in a particular way because it happens in the same organ, the breasts. However, medical literature rarely presented a synchronous malignancy case, prompting the publishing of this case. With improved cancer treatment and more prolonged survival, the number of patients with double cancers is increasing.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84635184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ni Putu Wulan Purnama Sari, Agustina Chriswinda Bura Mare
Background: There is a growing trend for those with a terminal illnesses to be cared for by their families at home. Globally, there is a growing governmental policy to engage caregivers, families, and communities in the healthcare delivery system. Family caregivers (FCG) have taken responsibility for the day-to-day care of their ill loved ones at home. A cancer diagnosis is a major event for the person diagnosed and also for his or her family and caregivers. The caregiving activity has a significant impact on FCG’s quality of life (QOL). This study aimed to analyze the best predictor of FCG’s QOL of female cancer patients in a community setting.Methods: This cross-sectional study involved five Public Health Centers (PHCs) among 63 PHCs in Surabaya (7.94%), Indonesia, which were selected by one-stage cluster random sampling. There were 60 FCGs of female cancer patients who participated in this study (n = 60). The Caregiver Quality of Life – Cancer (CQOLC) was a valid and reliable instrument that was used to collect the data. Linear regression and one-way ANOVA tests were used in data analysis (α < .05). Ethical clearance was issued.Results: Most respondents were middle-aged married men with sufficient educational background and still actively working with sufficient income. Their QOL was mostly at a moderate level (Mean ± SD = 62.57 ± 16.23). Burden (p < 0.000), disruptiveness (p = 0.001), and financial concern (p < 0.000) were significantly different between the low, moderate, and high FCG’s QOL. The best predictor of FCG’s QOL of female cancer patients in a community setting was disruptiveness (R2 = 0.622; p < 0.000) compared to burden (R2 = 0.531; p < 0.000) and financial concern (R2 = 0.184; p = 0.001), especially when other family members have not shown interest in caregiving (R2 = 0.539; p < 0.000). Conclusions: FCG’s QOL of female cancer patients in a community setting is at a moderate level. Disruptiveness, burden, and financial concern could predict FCG’s QOL significantly. The other family members’ disinterest in caregiving which belongs to the disruptiveness domain is the best predictor of FCG’s QOL of female cancer patients in a community setting, which accounted for 53.9% variance of QOL in this population
{"title":"Predictors of Quality of Life of Family Caregiver in A Community Setting: Breast and Cervical Cancer Impacts","authors":"Ni Putu Wulan Purnama Sari, Agustina Chriswinda Bura Mare","doi":"10.33371/ijoc.v16i4.820","DOIUrl":"https://doi.org/10.33371/ijoc.v16i4.820","url":null,"abstract":"Background: There is a growing trend for those with a terminal illnesses to be cared for by their families at home. Globally, there is a growing governmental policy to engage caregivers, families, and communities in the healthcare delivery system. Family caregivers (FCG) have taken responsibility for the day-to-day care of their ill loved ones at home. A cancer diagnosis is a major event for the person diagnosed and also for his or her family and caregivers. The caregiving activity has a significant impact on FCG’s quality of life (QOL). This study aimed to analyze the best predictor of FCG’s QOL of female cancer patients in a community setting.Methods: This cross-sectional study involved five Public Health Centers (PHCs) among 63 PHCs in Surabaya (7.94%), Indonesia, which were selected by one-stage cluster random sampling. There were 60 FCGs of female cancer patients who participated in this study (n = 60). The Caregiver Quality of Life – Cancer (CQOLC) was a valid and reliable instrument that was used to collect the data. Linear regression and one-way ANOVA tests were used in data analysis (α < .05). Ethical clearance was issued.Results: Most respondents were middle-aged married men with sufficient educational background and still actively working with sufficient income. Their QOL was mostly at a moderate level (Mean ± SD = 62.57 ± 16.23). Burden (p < 0.000), disruptiveness (p = 0.001), and financial concern (p < 0.000) were significantly different between the low, moderate, and high FCG’s QOL. The best predictor of FCG’s QOL of female cancer patients in a community setting was disruptiveness (R2 = 0.622; p < 0.000) compared to burden (R2 = 0.531; p < 0.000) and financial concern (R2 = 0.184; p = 0.001), especially when other family members have not shown interest in caregiving (R2 = 0.539; p < 0.000). Conclusions: FCG’s QOL of female cancer patients in a community setting is at a moderate level. Disruptiveness, burden, and financial concern could predict FCG’s QOL significantly. The other family members’ disinterest in caregiving which belongs to the disruptiveness domain is the best predictor of FCG’s QOL of female cancer patients in a community setting, which accounted for 53.9% variance of QOL in this population","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83352997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siska Dwiyantie Wahyuni, S. Suryanti, H. Agustina, B. Hernowo
Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary tract cancer. Most of the patients were diagnosed with advanced stages, and many have metastasized. Metastasis is responsible for 90% of cancer deaths compared to the primary tumor itself. In previous research, the expression of CXCR4 and MMP-9 has been suggested to correlate with metastasis and prognosis in several cancers. This study aimed to analyze the association of CXCR4 and MMP-9 expression with metastasis in infiltrating urothelial carcinoma of the bladder. Methods: This cross-sectional study included 40 selected paraffin-embedded tissue blocks from histopathologically diagnosed IUCB patients, consisting of 20 cases of non-metastasizing and 20 cases of metastasizing IUCB. Immunohistochemical staining for CXCR4 and MMP-9 was performed in all cases. All data were analyzed using the Chi-Square test with p < 0.05 of a significant level and then processed using SPSS 24.0 for Windows.Results: High CXCR4 immunoexpression was found in 18 (45%) of all cases, and high MMP-9 immunoexpression was found in 19 (47.5%) cases. High immunoexpression of CXCR4 and MMP9 in infiltrating urothelial carcinoma of the bladder showed significant association with metastasis (p < 0.05). The stepwise logistic regression analysis revealed that both CXCR-4 and MMP-9 immunoexpressions were independent prognostic factors for metastasis.Conclusions: CXCR4 and MMP-9 play a role in the metastatic process in infiltrating urothelial carcinoma of the bladder.
背景:膀胱浸润性尿路上皮癌(IUCB)是一种侵袭性尿路癌。大多数患者被诊断为晚期，许多患者已经转移。与原发肿瘤本身相比，90%的癌症死亡由转移引起。在先前的研究中，CXCR4和MMP-9的表达被认为与几种癌症的转移和预后有关。本研究旨在分析CXCR4和MMP-9表达与浸润性膀胱尿路上皮癌转移的关系。方法:本横断面研究选取组织病理学诊断的IUCB患者石蜡包埋组织块40例，其中非转移性IUCB和转移性IUCB各20例。所有病例均行CXCR4和MMP-9免疫组化染色。所有数据采用χ 2检验，p < 0.05为显著水平，然后使用SPSS 24.0 for Windows进行处理。结果:CXCR4高表达18例(45%)，MMP-9高表达19例(47.5%)。CXCR4和MMP9在膀胱浸润性尿路上皮癌中的高表达与转移有显著相关性(p < 0.05)。逐步logistic回归分析显示，CXCR-4和MMP-9免疫表达均为转移的独立预后因素。结论:CXCR4和MMP-9参与膀胱浸润性尿路上皮癌的转移过程。
{"title":"CXCR4 and MMP-9 Immunoexpression are Associated with Metastasis in Infiltrating Urothelial Carcinoma of The Bladder","authors":"Siska Dwiyantie Wahyuni, S. Suryanti, H. Agustina, B. Hernowo","doi":"10.33371/ijoc.v16i3.892","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.892","url":null,"abstract":"Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary tract cancer. Most of the patients were diagnosed with advanced stages, and many have metastasized. Metastasis is responsible for 90% of cancer deaths compared to the primary tumor itself. In previous research, the expression of CXCR4 and MMP-9 has been suggested to correlate with metastasis and prognosis in several cancers. This study aimed to analyze the association of CXCR4 and MMP-9 expression with metastasis in infiltrating urothelial carcinoma of the bladder. Methods: This cross-sectional study included 40 selected paraffin-embedded tissue blocks from histopathologically diagnosed IUCB patients, consisting of 20 cases of non-metastasizing and 20 cases of metastasizing IUCB. Immunohistochemical staining for CXCR4 and MMP-9 was performed in all cases. All data were analyzed using the Chi-Square test with p < 0.05 of a significant level and then processed using SPSS 24.0 for Windows.Results: High CXCR4 immunoexpression was found in 18 (45%) of all cases, and high MMP-9 immunoexpression was found in 19 (47.5%) cases. High immunoexpression of CXCR4 and MMP9 in infiltrating urothelial carcinoma of the bladder showed significant association with metastasis (p < 0.05). The stepwise logistic regression analysis revealed that both CXCR-4 and MMP-9 immunoexpressions were independent prognostic factors for metastasis.Conclusions: CXCR4 and MMP-9 play a role in the metastatic process in infiltrating urothelial carcinoma of the bladder.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74282748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Nuryanto, K. Sumapraja, Marcel Elian Suwito, E. R. Gunardi, S. Adjie, T. Utami
Background: Hysterectomy is the most common non-obstetric surgery in adult, reproductive-age women. Hysterectomy with or without ovarian conservation is known to increase the risk of cardiovascular disease. However, only a few studies regarding its immediate and short-term effects on hypertension are available. This study aimed to determine changes in blood pressure after a hysterectomy procedure.Methods: This study is a prospective cohort study of patients who underwent a total hysterectomy procedure with or without ovarian conservation at Cipto Mangunkusumo Hospital, Indonesia, from July 2018 to July 2020. Samples were grouped into patients with total hysterectomy only or hysterectomy with ovarian conservation (HT/HTSOU) and bilateral salpingo-oophorectomy hysterectomy (HTSOB). Statistical analysis was done using paired t-test and Wilcoxon test. Results: There were 80 patients included in this study (40 for each group). A significant increase in all blood pressure components occurred at 12 months after the HT/HTSOU and HTSOB procedures (p < 0.05). After six months of the HTSOB procedure, the increase in blood pressure components only occurred in systolic blood pressure and mean arterial pressure (MAP) (p < 0.05).Conclusions: There was a significant increase in all blood pressure components in the HT/HTSOU and HTSOB group at 12 months following hysterectomy while there was a significant increase in systolic blood pressure and MAP in the HTSOB group at 6 months following hysterectomy.
{"title":"Blood Pressure Elevation Timing Following Hysterectomy","authors":"K. Nuryanto, K. Sumapraja, Marcel Elian Suwito, E. R. Gunardi, S. Adjie, T. Utami","doi":"10.33371/ijoc.v16i3.901","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.901","url":null,"abstract":"Background: Hysterectomy is the most common non-obstetric surgery in adult, reproductive-age women. Hysterectomy with or without ovarian conservation is known to increase the risk of cardiovascular disease. However, only a few studies regarding its immediate and short-term effects on hypertension are available. This study aimed to determine changes in blood pressure after a hysterectomy procedure.Methods: This study is a prospective cohort study of patients who underwent a total hysterectomy procedure with or without ovarian conservation at Cipto Mangunkusumo Hospital, Indonesia, from July 2018 to July 2020. Samples were grouped into patients with total hysterectomy only or hysterectomy with ovarian conservation (HT/HTSOU) and bilateral salpingo-oophorectomy hysterectomy (HTSOB). Statistical analysis was done using paired t-test and Wilcoxon test. Results: There were 80 patients included in this study (40 for each group). A significant increase in all blood pressure components occurred at 12 months after the HT/HTSOU and HTSOB procedures (p < 0.05). After six months of the HTSOB procedure, the increase in blood pressure components only occurred in systolic blood pressure and mean arterial pressure (MAP) (p < 0.05).Conclusions: There was a significant increase in all blood pressure components in the HT/HTSOU and HTSOB group at 12 months following hysterectomy while there was a significant increase in systolic blood pressure and MAP in the HTSOB group at 6 months following hysterectomy.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85155521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Aryana, P. A. Adiputra, Yulan Permatasari, P. Prayudi, Hendra P. Setiawan
Background: The elderly population in Indonesia will continue to increase over the next few decades. Breast cancer is 22.9% of all female cancers, and aging is one of the biggest risk factors. The challenge in managing older cancer patients is the ability to accurately assess whether the expected benefits of treatment outweigh the risks. Epidemiological data is very important for research and the advancement of medical science in the future. Currently, the incidence of breast cancer in Indonesia is 26 per 100,000 population, but the incidence of breast cancer in the elderly is unknown.Methods: This is a descriptive study of all breast cancer cases recorded in the cancer registry of Sanglah General Hospital, the largest cancer registry in Bali. Statistical analyses were conducted using descriptive statistics with the Statistical Package for the Social Sciences version 16.0 (SPSS).Results: From 1997 until 2013, 1,020 cases of breast cancer among Balinese women of various ages were recorded, of which only 78 cases (7.6%) were attributed to the elderly (age ≥ 65 years). At the time of diagnosis, distant metastasis was recorded for 28.9% of the elderly, compared with 24.4% for the younger group of patients (age < 65 years). Locally advanced breast cancer (LABC) was also recorded higher in the elderly (49.4% vs. 47.5%). A lower proportion of primary surgical treatment was recorded for the elderly than for the younger group of patients (69.7% vs. 76.2%). A lower proportion of adjuvant therapy, either by chemotherapy or radiotherapy, was also recorded for the elderly (45.5% vs. 53.4% and 2.6% vs. 4.9%, respectively), but the proportion of adjuvant hormonal therapy was recorded higher in the elderly (1.3% vs. 0.7%). In contrast, palliative care was recorded higher in the elderly (7.7% vs. 5.7%). Unfortunately, no data about survival were available.Conclusions: There is a tendency for older women in Bali to have more advanced disease at the time of diagnosis and receive less surgical treatment as the primary therapy, but they are more likely to receive adjuvant hormonal therapy and palliative care than their younger counterparts. This information should be of major interest to clinicians.
{"title":"Breast Cancer in the Balinese Elderly Population: Analysis of the Hospital-Based Cancer Registry","authors":"I. Aryana, P. A. Adiputra, Yulan Permatasari, P. Prayudi, Hendra P. Setiawan","doi":"10.33371/ijoc.v16i3.895","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.895","url":null,"abstract":"Background: The elderly population in Indonesia will continue to increase over the next few decades. Breast cancer is 22.9% of all female cancers, and aging is one of the biggest risk factors. The challenge in managing older cancer patients is the ability to accurately assess whether the expected benefits of treatment outweigh the risks. Epidemiological data is very important for research and the advancement of medical science in the future. Currently, the incidence of breast cancer in Indonesia is 26 per 100,000 population, but the incidence of breast cancer in the elderly is unknown.Methods: This is a descriptive study of all breast cancer cases recorded in the cancer registry of Sanglah General Hospital, the largest cancer registry in Bali. Statistical analyses were conducted using descriptive statistics with the Statistical Package for the Social Sciences version 16.0 (SPSS).Results: From 1997 until 2013, 1,020 cases of breast cancer among Balinese women of various ages were recorded, of which only 78 cases (7.6%) were attributed to the elderly (age ≥ 65 years). At the time of diagnosis, distant metastasis was recorded for 28.9% of the elderly, compared with 24.4% for the younger group of patients (age < 65 years). Locally advanced breast cancer (LABC) was also recorded higher in the elderly (49.4% vs. 47.5%). A lower proportion of primary surgical treatment was recorded for the elderly than for the younger group of patients (69.7% vs. 76.2%). A lower proportion of adjuvant therapy, either by chemotherapy or radiotherapy, was also recorded for the elderly (45.5% vs. 53.4% and 2.6% vs. 4.9%, respectively), but the proportion of adjuvant hormonal therapy was recorded higher in the elderly (1.3% vs. 0.7%). In contrast, palliative care was recorded higher in the elderly (7.7% vs. 5.7%). Unfortunately, no data about survival were available.Conclusions: There is a tendency for older women in Bali to have more advanced disease at the time of diagnosis and receive less surgical treatment as the primary therapy, but they are more likely to receive adjuvant hormonal therapy and palliative care than their younger counterparts. This information should be of major interest to clinicians.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75652408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andi Kurniadi, Rose Dita Prasetyawati, Heti Prasekti
Introduction: Bladder flap hematoma (BFH) is a rare complication of cesarean section (CS). BFH appears between the bladder and the lower uterine segment (LUS) when the visceral peritoneal is closed during traditional CS techniques and decreased uterine contractions. Surgery is the treatment of choice for the management of peritoneal closure in CS and the decrease in uterine contractions that cause BFH.Case Presentation: A 35-year-old G3P2A0 underwent a cesarean delivery due to fetal distress. CS was performed with the visceral peritoneal sutured as in the traditional technique. Six hours after CS, there was an increase in abdominal circumference, muscle defenses, hypotension, tachycardia, anemia, and leukocytosis. She had to undergo repeated laparotomy with acute abdomen after CS and hysterectomy because uterine atony was found.Conclusions: BFH can be caused by peritoneal closure during CS and decreased uterine contractions or uterine atony. Although there is no standard protocol for management, surgical approaches for cases with infection or bleeding and hysterectomy are performed to save the patient’s life from uterine atony.
{"title":"Post-Supravaginal Hysterectomy for Bladder Flap Hematoma in P3A0 Preterm Delivery by Cesarean Section due to Fetal Distress","authors":"Andi Kurniadi, Rose Dita Prasetyawati, Heti Prasekti","doi":"10.33371/ijoc.v16i3.877","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.877","url":null,"abstract":"Introduction: Bladder flap hematoma (BFH) is a rare complication of cesarean section (CS). BFH appears between the bladder and the lower uterine segment (LUS) when the visceral peritoneal is closed during traditional CS techniques and decreased uterine contractions. Surgery is the treatment of choice for the management of peritoneal closure in CS and the decrease in uterine contractions that cause BFH.Case Presentation: A 35-year-old G3P2A0 underwent a cesarean delivery due to fetal distress. CS was performed with the visceral peritoneal sutured as in the traditional technique. Six hours after CS, there was an increase in abdominal circumference, muscle defenses, hypotension, tachycardia, anemia, and leukocytosis. She had to undergo repeated laparotomy with acute abdomen after CS and hysterectomy because uterine atony was found.Conclusions: BFH can be caused by peritoneal closure during CS and decreased uterine contractions or uterine atony. Although there is no standard protocol for management, surgical approaches for cases with infection or bleeding and hysterectomy are performed to save the patient’s life from uterine atony.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90030585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Paskarani, N. Winarti, Santi Maya Lestari Siahaan, Made Dalika Nareswari
Introduction: Histopathological features of the lung parenchyma due to the Alveolar-Pleural Fistula (APF) in a patient with post-COVID-19 infection have not been reported. APF usually occurs after a spontaneous pneumothorax. Spontaneous pneumothorax is an abnormal traumatic accumulation of air within the pleural space. It is classified as primary or secondary pneumothorax based on multiple risk factors.Case Presentation: A sixty-four-year-old patient was referred from one of the remote hospitals in the west of Bali due to spontaneous simple pneumothorax dextra. A week after being diagnosed with COVID-19 infection, the patient underwent a bullectomy procedure and was clinically diagnosed with recurrent spontaneous pneumothorax dextra due to APF. Then, the bullectomy specimen was sent to the anatomical pathology laboratory. Histopathology test revealed extensive areas of necrosis and fibrosis with scattered lymphocytes and emphysematous alveoli found in APF lesions. Conclusions: In conclusion, the evidence of extended fibrosis, which destroys the pulmonary parenchymal septum and dilated alveoli with diffuse fibrosis in the subpleural and intraparenchymal areas, may cause impairment of both perfusion and ventilation. Unfortunately, viral cytopathic like-changes related to COVID-19, such as multinucleated cells with large nuclei, amphophilic cytoplasm, and prominent nucleoli in alveolar spaces with intranuclear inclusions, were not found in this case. In this case, surgery is needed in case of fistula, either related or unrelated to infection of the pleural cavity indicating the patient’s functional recovery.
{"title":"Histopathological Features of the Lung Parenchyma in a 64-Year-Old Male Patient with Post-COVID-19 Infection with Spontaneous Pneumothorax Dextra Due to AlveolarPleural Fistula (APF): A Case Report","authors":"P. Paskarani, N. Winarti, Santi Maya Lestari Siahaan, Made Dalika Nareswari","doi":"10.33371/ijoc.v16i3.888","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.888","url":null,"abstract":"Introduction: Histopathological features of the lung parenchyma due to the Alveolar-Pleural Fistula (APF) in a patient with post-COVID-19 infection have not been reported. APF usually occurs after a spontaneous pneumothorax. Spontaneous pneumothorax is an abnormal traumatic accumulation of air within the pleural space. It is classified as primary or secondary pneumothorax based on multiple risk factors.Case Presentation: A sixty-four-year-old patient was referred from one of the remote hospitals in the west of Bali due to spontaneous simple pneumothorax dextra. A week after being diagnosed with COVID-19 infection, the patient underwent a bullectomy procedure and was clinically diagnosed with recurrent spontaneous pneumothorax dextra due to APF. Then, the bullectomy specimen was sent to the anatomical pathology laboratory. Histopathology test revealed extensive areas of necrosis and fibrosis with scattered lymphocytes and emphysematous alveoli found in APF lesions. Conclusions: In conclusion, the evidence of extended fibrosis, which destroys the pulmonary parenchymal septum and dilated alveoli with diffuse fibrosis in the subpleural and intraparenchymal areas, may cause impairment of both perfusion and ventilation. Unfortunately, viral cytopathic like-changes related to COVID-19, such as multinucleated cells with large nuclei, amphophilic cytoplasm, and prominent nucleoli in alveolar spaces with intranuclear inclusions, were not found in this case. In this case, surgery is needed in case of fistula, either related or unrelated to infection of the pleural cavity indicating the patient’s functional recovery.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89885348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kelvin Candiago, E. Manuputty, Syamsu Hudaya, Yulius Fajar Martanu, Budiawan Atmadja, A. Harahap, Yosephine G Susufi, Yustinus Hartanto, Ajeng Indah Pramesti
Introduction: Adrenal ganglioneuroma is an extremely rare and benign tumor comprising Schwann cells and ganglion cells. Adrenal ganglioneuroma is usually hormonally silent and tends to be discovered incidentally on imaging tests. Here, we present a case of a 39-year-old man with adrenal ganglioneuroma who underwent laparoscopic left adrenalectomy.Case Presentation: a 39-year-old man was admitted to our department with left flank pain after he recovered from Covid-19. He had no symptoms of nausea, vomiting, headache, diarrhea, palpitation, or chest distress, and there was no lack of appetite or weight loss. He denied any medical conditions, such as hyperaldosteronism, hypercortisolism, and hypertension. On further examination with contrast-enhanced CT identified a hypo-isodense mass in the left adrenal gland, measuring 4.8 x 4.4 x 5.0 cm, and spotty dense calcification in the middle of the mass. All functional laboratory evolution showed negative including urinalysis and serum electrolyte. Because the non-functioning suprarenal tumor was presumed to be benign, a laparoscopic approach was planned for definitive extirpation of the left adrenal gland. CT triple-phase whole abdomen was done before the procedure which showed contrast-enhanced identified an isodense mass with 43 HU in the left adrenal gland, measuring 4.8 x 4.4 x 5.0 cm with absolute washout of 49.3% and relative washout of 30.7%. Laparoscopic left adrenalectomy was performed. The patient underwent successful laparoscopic extirpation of the left adrenal gland. The postoperative pathology revealed a 7.0 x 6.0 x 3.0 cm encapsulated tumor with a firm texture. Microscopically, the tumor showed a mixture of mature ganglion cells and fascicles of Schwann cells. Adrenocortical cells were found near the capsule.Conclusions: Even though there have been some guidelines for the diagnosis of Adrenal ganglioneuroma, pre-operative misdiagnoses are still frequent. We recommend that complete operative resection should be considered once malignancy cannot be excluded by pre-operative evaluation. Laparoscopic adrenalectomy is a reasonable option at least for tumors < or = 4.5 cm. Adrenal ganglioneuroma can be successfully excised laparoscopically with an appropriate and experienced surgeon.
简介:肾上腺神经节神经瘤是一种由雪旺细胞和神经节细胞组成的极为罕见的良性肿瘤。肾上腺神经节神经瘤通常无激素表现，往往在影像学检查中偶然发现。在此，我们报告一个39岁男性肾上腺神经节神经瘤的病例，他接受了腹腔镜左肾上腺切除术。病例介绍:一名39岁男性，新冠肺炎康复后因左侧疼痛入院。他没有恶心、呕吐、头痛、腹泻、心悸或胸闷的症状，也没有食欲不振或体重减轻。他否认有任何疾病，如醛固酮增多症、高皮质醇血症和高血压。进一步CT增强检查发现左侧肾上腺低等密度肿块，尺寸为4.8 x 4.4 x 5.0 cm，肿块中部有点状致密钙化。所有功能实验室检测结果均为阴性，包括尿液和血清电解质。由于无功能的肾上肿瘤被认为是良性的，因此计划采用腹腔镜方法切除左侧肾上腺。术前行全腹CT三期增强扫描，左侧肾上腺见43 HU等致密肿块，尺寸4.8 x 4.4 x 5.0 cm，绝对洗脱率49.3%，相对洗脱率30.7%。行腹腔镜左肾上腺切除术。病人接受了成功的腹腔镜左肾上腺摘除手术。术后病理显示一个7.0 x 6.0 x 3.0 cm的包膜肿瘤，质地坚硬。显微镜下，肿瘤显示成熟神经节细胞和雪旺细胞束的混合物。被膜附近可见肾上腺皮质细胞。结论:尽管有一些肾上腺神经节神经瘤的诊断指南，但术前误诊仍然很常见。我们建议，一旦术前评估不能排除恶性肿瘤，应考虑完全手术切除。至少对于小于或= 4.5 cm的肿瘤，腹腔镜肾上腺切除术是一个合理的选择。肾上腺神经节神经瘤可以成功切除腹腔镜与适当的和有经验的外科医生。
{"title":"Laparoscopic Approach in Large Rare Adrenal Ganglioneuroma","authors":"Kelvin Candiago, E. Manuputty, Syamsu Hudaya, Yulius Fajar Martanu, Budiawan Atmadja, A. Harahap, Yosephine G Susufi, Yustinus Hartanto, Ajeng Indah Pramesti","doi":"10.33371/ijoc.v16i3.889","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.889","url":null,"abstract":"Introduction: Adrenal ganglioneuroma is an extremely rare and benign tumor comprising Schwann cells and ganglion cells. Adrenal ganglioneuroma is usually hormonally silent and tends to be discovered incidentally on imaging tests. Here, we present a case of a 39-year-old man with adrenal ganglioneuroma who underwent laparoscopic left adrenalectomy.Case Presentation: a 39-year-old man was admitted to our department with left flank pain after he recovered from Covid-19. He had no symptoms of nausea, vomiting, headache, diarrhea, palpitation, or chest distress, and there was no lack of appetite or weight loss. He denied any medical conditions, such as hyperaldosteronism, hypercortisolism, and hypertension. On further examination with contrast-enhanced CT identified a hypo-isodense mass in the left adrenal gland, measuring 4.8 x 4.4 x 5.0 cm, and spotty dense calcification in the middle of the mass. All functional laboratory evolution showed negative including urinalysis and serum electrolyte. Because the non-functioning suprarenal tumor was presumed to be benign, a laparoscopic approach was planned for definitive extirpation of the left adrenal gland. CT triple-phase whole abdomen was done before the procedure which showed contrast-enhanced identified an isodense mass with 43 HU in the left adrenal gland, measuring 4.8 x 4.4 x 5.0 cm with absolute washout of 49.3% and relative washout of 30.7%. Laparoscopic left adrenalectomy was performed. The patient underwent successful laparoscopic extirpation of the left adrenal gland. The postoperative pathology revealed a 7.0 x 6.0 x 3.0 cm encapsulated tumor with a firm texture. Microscopically, the tumor showed a mixture of mature ganglion cells and fascicles of Schwann cells. Adrenocortical cells were found near the capsule.Conclusions: Even though there have been some guidelines for the diagnosis of Adrenal ganglioneuroma, pre-operative misdiagnoses are still frequent. We recommend that complete operative resection should be considered once malignancy cannot be excluded by pre-operative evaluation. Laparoscopic adrenalectomy is a reasonable option at least for tumors < or = 4.5 cm. Adrenal ganglioneuroma can be successfully excised laparoscopically with an appropriate and experienced surgeon.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73716014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suci Iriani, Agus Alim Abdullah, D. Muhadi, M. Arif
Introduction: Acute Leukemia with Mixed Lineage phenotype (MLL) is leukemia that consists of cells characterized by mixed lineage markers, both from myeloid and lymphoid cells. The incidence of this leukemia is only 2-5% of all acute leukemias and is considered to have a poor prognosis.Case Presentation: A seven-year-old girl was diagnosed with MLL. The results of immunophenotyping showed two blast populations with the expressions of CD33, CD34, HLA-DR, CD117, CD13, CD19, CD10, CD20, CyMPO, Cy CD79a, and morphological features of Acute Lymphoblastic Leukemia (ALL) and Acute nonLymphocytic Leukemia (AnLL) on bone marrow aspiration. The BCR-ABL examination showed the detected BCR-ABL p210 (Major breakpoint), the majority of which was found in chronic myeloid leukemia (CML) patients. There is no definite pathogenesis of BCR-ABL p210 (MBCR-ABL) in this patient. BCR-ABL can also present in 11–29% of ALL patients but is relatively rare in childhood ALL (1%–3%) and mostly expresses p190 (minor breakpoint (mBCR-ABL)). The p210 BCR-ABL transcript is detected in 30% of adults and 20% of childhood ALL patients with Philadelphia ALL. Conclusions: MLL with BCR-ABL p210 transcript is very rare in acute leukemia. Immunophenotyping tests can detect typical MLL profiles, and WHO has standardized the diagnosis for MLL.
{"title":"Mixed-Lineage Leukemia","authors":"Suci Iriani, Agus Alim Abdullah, D. Muhadi, M. Arif","doi":"10.33371/ijoc.v16i3.875","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.875","url":null,"abstract":"Introduction: Acute Leukemia with Mixed Lineage phenotype (MLL) is leukemia that consists of cells characterized by mixed lineage markers, both from myeloid and lymphoid cells. The incidence of this leukemia is only 2-5% of all acute leukemias and is considered to have a poor prognosis.Case Presentation: A seven-year-old girl was diagnosed with MLL. The results of immunophenotyping showed two blast populations with the expressions of CD33, CD34, HLA-DR, CD117, CD13, CD19, CD10, CD20, CyMPO, Cy CD79a, and morphological features of Acute Lymphoblastic Leukemia (ALL) and Acute nonLymphocytic Leukemia (AnLL) on bone marrow aspiration. The BCR-ABL examination showed the detected BCR-ABL p210 (Major breakpoint), the majority of which was found in chronic myeloid leukemia (CML) patients. There is no definite pathogenesis of BCR-ABL p210 (MBCR-ABL) in this patient. BCR-ABL can also present in 11–29% of ALL patients but is relatively rare in childhood ALL (1%–3%) and mostly expresses p190 (minor breakpoint (mBCR-ABL)). The p210 BCR-ABL transcript is detected in 30% of adults and 20% of childhood ALL patients with Philadelphia ALL. Conclusions: MLL with BCR-ABL p210 transcript is very rare in acute leukemia. Immunophenotyping tests can detect typical MLL profiles, and WHO has standardized the diagnosis for MLL.","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74010267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Breast cancer is the most common cancer in women worldwide and in Indonesia. Most patients arrived at the hospital too late to receive the optimal benefit from breast cancer therapies, in which radiotherapy is one of the essential modalities. Radiotherapy is conducted as a local control by using the principle of ionizing radiation to eradicate the growth of cancer cells, hence reducing the chances of recurrence and enhancing survival rates. Some of the side effects include skin conditions that can manifest as redness and dry skin, fatigue, lymphedema, and chest wall fibrosis. Data and research on the profile of breast cancer patients with radiotherapy were still limited in Indonesia, particularly in West Java. This study aimed to assess the profile of breast cancer patients in Hasan Sadikin Hospital Bandung.Methods: This study was conducted with the retrospective descriptive quantitative method. The sampling technique was total sampling using 280 medical records of breast cancer patients with radiotherapy from January 1, 2018, until December 31, 2019, which were registered in the Hospital-Based Cancer Registry at the Radiotherapy Department, Hasan Sadikin General Hospital.Results: Breast cancer patients undergoing radiotherapy were mostly in the 45–54 years age group (36.4%). The most common chief complaint was a lump in the breast (66.4%), particularly in the left breast (45.0%). About 22.5% of all patients arrived at a locally advanced stage and 30.7% at an advanced stage with bone metastasis (10.6%), histopathological subtype Invasive Carcinoma No Special Type (IC-NST) (81.1%), and molecular subtype luminal B (9.6%). The most widely performed therapies were total mastectomy surgery (16.1%), neoadjuvant chemotherapy (62.9%), and complete adjuvant radiotherapy (47.1%) with External Beam Radiotherapy (EBRT) method using LINAC (71.1%).Conclusions: Breast cancer is a health burden in Hasan Sadikin General Hospital and remains one of the national health priorities. Further evaluation of management and follow-up studies need to be done to improve the implementation of therapies for patients and reduce the incidence rate
{"title":"Profile of Breast Cancer Patients with Radiotherapy in Hasan Sadikin Hospital Bandung","authors":"Atikah Larasati, Marhendra Satria Utama, Adji Kusumadjati","doi":"10.33371/ijoc.v16i3.873","DOIUrl":"https://doi.org/10.33371/ijoc.v16i3.873","url":null,"abstract":"Background: Breast cancer is the most common cancer in women worldwide and in Indonesia. Most patients arrived at the hospital too late to receive the optimal benefit from breast cancer therapies, in which radiotherapy is one of the essential modalities. Radiotherapy is conducted as a local control by using the principle of ionizing radiation to eradicate the growth of cancer cells, hence reducing the chances of recurrence and enhancing survival rates. Some of the side effects include skin conditions that can manifest as redness and dry skin, fatigue, lymphedema, and chest wall fibrosis. Data and research on the profile of breast cancer patients with radiotherapy were still limited in Indonesia, particularly in West Java. This study aimed to assess the profile of breast cancer patients in Hasan Sadikin Hospital Bandung.Methods: This study was conducted with the retrospective descriptive quantitative method. The sampling technique was total sampling using 280 medical records of breast cancer patients with radiotherapy from January 1, 2018, until December 31, 2019, which were registered in the Hospital-Based Cancer Registry at the Radiotherapy Department, Hasan Sadikin General Hospital.Results: Breast cancer patients undergoing radiotherapy were mostly in the 45–54 years age group (36.4%). The most common chief complaint was a lump in the breast (66.4%), particularly in the left breast (45.0%). About 22.5% of all patients arrived at a locally advanced stage and 30.7% at an advanced stage with bone metastasis (10.6%), histopathological subtype Invasive Carcinoma No Special Type (IC-NST) (81.1%), and molecular subtype luminal B (9.6%). The most widely performed therapies were total mastectomy surgery (16.1%), neoadjuvant chemotherapy (62.9%), and complete adjuvant radiotherapy (47.1%) with External Beam Radiotherapy (EBRT) method using LINAC (71.1%).Conclusions: Breast cancer is a health burden in Hasan Sadikin General Hospital and remains one of the national health priorities. Further evaluation of management and follow-up studies need to be done to improve the implementation of therapies for patients and reduce the incidence rate","PeriodicalId":13489,"journal":{"name":"Indonesian Journal of Cancer","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74725226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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