Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.9
Chizuko Koseki
There is no widely accepted definition for Interstitial cystitis (IC)/bladder pain syndrome (BPS) and very few effective diagnostic biomarkers. Chizuko Koseki is combining her deep knowledge of both urology and nucleic acid/oligonucleotides to develop innovative treatments for Hunner-type IC (HIC). Patients with IC/BPS are classified as either HIC, presenting with a specific Hunner lesion, or BPS presenting without Hunner lesion. There is a distinct lack of treatments, with only one approved drug; 50% dimethyl sulfoxide (DMSO) as intravesical instillation therapy, with the drug put directly into the bladder. An important study enabled scientists to surmise that HIC is a distinct inflammatory disorder that is characterised by pancystitis with an increase in plasma cells and frequent expansion of clonal B-cells, and epithelial denudation. Koseki is the CEO of TAGCyx Biotechnologies, a pre-clinical stage drug development company based in Komaba Open Laboratory, The University of Tokyo, Japan focused on developing novel nucleic acid-based drugs for therapeutic applications. The company focuses on: autoimmune disease; women's disease; apheresis; thrombosis; and chronic kidney disease. Oligonucleotides are key to Koseki's work; she is using the advantages and characteristics of single strand DNA oligonucleotides to develop some focused disease areas, such as autoimmune diseases, topical applications and women's diseases. The team has established a technology platform called Xenoligo® that can screen and stabilise drug candidates utilising oligonucleotide drug discovery. The platform can generate highly potent and efficacious single strand DNA aptamers. Interstitial cystitis, IC, bladder pain syndrome, BPS, urology, nucleic acid, oligonucleotides, Hunner-type IC, HIC, TAGCyx Biotechnologies, autoimmune disease, women's disease, apheresis, thrombosis, chronic kidney disease, oligonucleotide drug discovery, DNA aptamers.
{"title":"Anti-IFNg DNA aptamer for Hunner Type Interstitial Cystitis","authors":"Chizuko Koseki","doi":"10.21820/23987073.2023.3.9","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.9","url":null,"abstract":"There is no widely accepted definition for Interstitial cystitis (IC)/bladder pain syndrome (BPS) and very few effective diagnostic biomarkers. Chizuko Koseki is combining her deep knowledge of both urology and nucleic acid/oligonucleotides to develop innovative treatments for Hunner-type IC (HIC). Patients with IC/BPS are classified as either HIC, presenting with a specific Hunner lesion, or BPS presenting without Hunner lesion. There is a distinct lack of treatments, with only one approved drug; 50% dimethyl sulfoxide (DMSO) as intravesical instillation therapy, with the drug put directly into the bladder. An important study enabled scientists to surmise that HIC is a distinct inflammatory disorder that is characterised by pancystitis with an increase in plasma cells and frequent expansion of clonal B-cells, and epithelial denudation. Koseki is the CEO of TAGCyx Biotechnologies, a pre-clinical stage drug development company based in Komaba Open Laboratory, The University of Tokyo, Japan focused on developing novel nucleic acid-based drugs for therapeutic applications. The company focuses on: autoimmune disease; women's disease; apheresis; thrombosis; and chronic kidney disease. Oligonucleotides are key to Koseki's work; she is using the advantages and characteristics of single strand DNA oligonucleotides to develop some focused disease areas, such as autoimmune diseases, topical applications and women's diseases. The team has established a technology platform called Xenoligo® that can screen and stabilise drug candidates utilising oligonucleotide drug discovery. The platform can generate highly potent and efficacious single strand DNA aptamers. Interstitial cystitis, IC, bladder pain syndrome, BPS, urology, nucleic acid, oligonucleotides, Hunner-type IC, HIC, TAGCyx Biotechnologies, autoimmune disease, women's disease, apheresis, thrombosis, chronic kidney disease, oligonucleotide drug discovery, DNA aptamers.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.32
Tomihiko Daioku
There are also risks associated with X-rays as they are a form of radiation and although precautions are taken to protect patients, exposure of radiology personnel can be neglected. Senior Assistant Professor Tomihiko Daioku, from Chubu University, has been working to educate nurses about radiation in the workplace as many nurses may not have important knowledge about radiation and correct radiation protection methods and experience fear and anxiety about exposure. Given that nursing training courses are intensive, opportunities to learn about radiation are limited. Daioku believes it is vital to provide nurses with more education on radiology and equip them to stay safer in the workplace and has been developing an education programme to raise awareness of radiation and precautionary measures that can be taken by nurses. He has been using projection mapping and VR as useful educational tools for understanding the characteristics of invisible radiation, ensuring the teachings are fun and experience-based. As Daioku found that clinical experience was essential in recalling situations within the VR environment, he has been focusing on practising nurses, building a programme based on Kolb's experiential learning model. He has confirmed the efficacy of his teaching materials and wants to determine how to utilise these for nursing students without any clinical experience, with the additional hurdle that they have heavy workloads and therefore little time for lengthy education programmes.
{"title":"Construction of radiation protection training program for nurses using virtual reality","authors":"Tomihiko Daioku","doi":"10.21820/23987073.2023.3.32","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.32","url":null,"abstract":"There are also risks associated with X-rays as they are a form of radiation and although precautions are taken to protect patients, exposure of radiology personnel can be neglected. Senior Assistant Professor Tomihiko Daioku, from Chubu University, has been working to educate nurses about radiation in the workplace as many nurses may not have important knowledge about radiation and correct radiation protection methods and experience fear and anxiety about exposure. Given that nursing training courses are intensive, opportunities to learn about radiation are limited. Daioku believes it is vital to provide nurses with more education on radiology and equip them to stay safer in the workplace and has been developing an education programme to raise awareness of radiation and precautionary measures that can be taken by nurses. He has been using projection mapping and VR as useful educational tools for understanding the characteristics of invisible radiation, ensuring the teachings are fun and experience-based. As Daioku found that clinical experience was essential in recalling situations within the VR environment, he has been focusing on practising nurses, building a programme based on Kolb's experiential learning model. He has confirmed the efficacy of his teaching materials and wants to determine how to utilise these for nursing students without any clinical experience, with the additional hurdle that they have heavy workloads and therefore little time for lengthy education programmes.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.46
Tetsuya Takano
The brain is incredibly complex and there is so much we don't know about this organ and its mechanisms. Assistant Professor Tetsuya Takano, School of Medicine, Keio University, Japan, is working to better understand neuroscience. One area of interest is neurons and astrocytes; specifically elucidating the protein component functions in each neural circuit. He and his team are working to shed light on the pathological mechanism of psychiatric and neurological disorders and, in doing so, enabling improved treatments and benefiting patients across the globe. The team has developed spatio-temporal proteome technologies: TurboID-surface and Split-TurboID, that can not only explain the formation and operation principle of neural networks, but also provide essential knowledge for research into psychiatric and neurological diseases. To overcome limitations associated with conventional proteome analysis, Takano and the team recently developed a new in vivo proximal-dependent biotin labelling (BioID) method. Using this, the researchers can label and analyse adjacent proteins with biotin, which enables them to comprehensively analyse local protein components within cells with extremely high spatial resolution. The team has used the BioID method to develop the Split-TurboID method and an innovative spatial proteome technique for searching for molecular groups among heterogeneous cells that makes it possible to comprehensively analyse the protein components in the vicinity of the adhesion site. Using the Split-TurboID method, the team has comprehensively searched for functional molecules between astrocytes and neurons and revealed that astrocytes directly control the formation of inhibitory synapses and neuronal activity in neurons via a novel tripartite synaptic molecule known as NRCAM.
{"title":"Comprehensive identification of molecules at synapses and non-synaptic cell-adhesion structure","authors":"Tetsuya Takano","doi":"10.21820/23987073.2023.3.46","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.46","url":null,"abstract":"The brain is incredibly complex and there is so much we don't know about this organ and its mechanisms. Assistant Professor Tetsuya Takano, School of Medicine, Keio University, Japan, is working to better understand neuroscience. One area of interest is neurons and astrocytes; specifically elucidating the protein component functions in each neural circuit. He and his team are working to shed light on the pathological mechanism of psychiatric and neurological disorders and, in doing so, enabling improved treatments and benefiting patients across the globe. The team has developed spatio-temporal proteome technologies: TurboID-surface and Split-TurboID, that can not only explain the formation and operation principle of neural networks, but also provide essential knowledge for research into psychiatric and neurological diseases. To overcome limitations associated with conventional proteome analysis, Takano and the team recently developed a new in vivo proximal-dependent biotin labelling (BioID) method. Using this, the researchers can label and analyse adjacent proteins with biotin, which enables them to comprehensively analyse local protein components within cells with extremely high spatial resolution. The team has used the BioID method to develop the Split-TurboID method and an innovative spatial proteome technique for searching for molecular groups among heterogeneous cells that makes it possible to comprehensively analyse the protein components in the vicinity of the adhesion site. Using the Split-TurboID method, the team has comprehensively searched for functional molecules between astrocytes and neurons and revealed that astrocytes directly control the formation of inhibitory synapses and neuronal activity in neurons via a novel tripartite synaptic molecule known as NRCAM.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.15
Ken-Ichi Kobayashi
Fibrosis is a condition in which tissue thickens or scars in response to injury. It can affect multiple parts of the human body, including organs, but there are few treatments. The condition was previously thought to be irreversible but, since the discovery that fibrosis is not captured in any single particular organ, but is caused by a complex network of cells and organs, researchers believe there is a common pathophysiological mechanism at play, and the condition may be reversible. Professor Ken-Ichi Kobayashi, Notre Dame Seishin University, Japan, is working on a project to discover more about the mechanisms involved in organ fibrosis, with a focus on the role that quinolinic acid, a known neurotoxin, might play. Reports that quinolinic acid is increased in the brain in varied conditions led to the ‘Quinolinic Acid Hypothesis’. In a study focused on obesity-induced NASH diet, the researchers examined the effects on the liver and other organs and found that the kynurenine metabolic pathway was decreased in the liver of NASH. The team also demonstrated for the first time that fibrosis is enhanced in the liver and the kidney in a GAN diet-induced NASH mouse model. The researchers also showed that the liver and kidneys have very different effects on the kynurenine metabolic pathway. The researchers want to clarify the relationship with non-alcoholic fatty pancreas (NAFPD) and other organs, to better understand the pathomechanisms of organ fibrosis. Based on these findings, they are now focusing on renal fibrosis and researching food ingredients that prevent and improve organ fibrosis.
{"title":"Elucidation of the organ fibrosis-inducing action of quinolinic acid and search for food ingredients that protect the body from organ fibrosis","authors":"Ken-Ichi Kobayashi","doi":"10.21820/23987073.2023.3.15","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.15","url":null,"abstract":"Fibrosis is a condition in which tissue thickens or scars in response to injury. It can affect multiple parts of the human body, including organs, but there are few treatments. The condition was previously thought to be irreversible but, since the discovery that fibrosis is not captured in any single particular organ, but is caused by a complex network of cells and organs, researchers believe there is a common pathophysiological mechanism at play, and the condition may be reversible. Professor Ken-Ichi Kobayashi, Notre Dame Seishin University, Japan, is working on a project to discover more about the mechanisms involved in organ fibrosis, with a focus on the role that quinolinic acid, a known neurotoxin, might play. Reports that quinolinic acid is increased in the brain in varied conditions led to the ‘Quinolinic Acid Hypothesis’. In a study focused on obesity-induced NASH diet, the researchers examined the effects on the liver and other organs and found that the kynurenine metabolic pathway was decreased in the liver of NASH. The team also demonstrated for the first time that fibrosis is enhanced in the liver and the kidney in a GAN diet-induced NASH mouse model. The researchers also showed that the liver and kidneys have very different effects on the kynurenine metabolic pathway. The researchers want to clarify the relationship with non-alcoholic fatty pancreas (NAFPD) and other organs, to better understand the pathomechanisms of organ fibrosis. Based on these findings, they are now focusing on renal fibrosis and researching food ingredients that prevent and improve organ fibrosis.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.4
Lucy Annette
Cancer diagnoses are on the rise but survival rates are increasing thanks to advances in scientific and technological innovation, which have presented new prevention and treatment opportunities that are allowing people with cancer to live longer, healthier lives. Sustained research efforts are key to reducing the cancer burden and Europe's Beating Cancer Plan is an important part of the European Commission's (EC) ongoing action against the disease. It was adopted in February 2021 and represents an ongoing commitment to prevent cancer, support equal access to care and improve the lives of the many people affected by cancer. ´This is first and foremost about people. About celebrating and reinforcing resilience and treating cancer as a disease that can and must be overcome. A strong European Health Union is a Union where citizens are protected from avoidable cancers, where they have access to early screening and diagnosis, and where everyone is empowered with access to high quality care, at every step of the way. This is what we want to achieve with our Cancer Plan,´ said Stella Kyriakides, Commissioner for Health and Food Safety, upon the Plan's launch. It is structured around prevention, early detection, diagnosis and treatment and quality of life of cancer patients and survivors and built on 10 flagship initiatives that cover: new technologies, research and innovation; sustainable cancer prevention; improving early detection; ensuring high standards in care; improving quality of life; reducing cancer equalities; and enhancing the focus on childhood cancer.
{"title":"Fighting the good fight: Europeâ–™s Beating Cancer Plan","authors":"Lucy Annette","doi":"10.21820/23987073.2023.3.4","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.4","url":null,"abstract":"Cancer diagnoses are on the rise but survival rates are increasing thanks to advances in scientific and technological innovation, which have presented new prevention and treatment opportunities that are allowing people with cancer to live longer, healthier lives. Sustained research efforts are key to reducing the cancer burden and Europe's Beating Cancer Plan is an important part of the European Commission's (EC) ongoing action against the disease. It was adopted in February 2021 and represents an ongoing commitment to prevent cancer, support equal access to care and improve the lives of the many people affected by cancer. ´This is first and foremost about people. About celebrating and reinforcing resilience and treating cancer as a disease that can and must be overcome. A strong European Health Union is a Union where citizens are protected from avoidable cancers, where they have access to early screening and diagnosis, and where everyone is empowered with access to high quality care, at every step of the way. This is what we want to achieve with our Cancer Plan,´ said Stella Kyriakides, Commissioner for Health and Food Safety, upon the Plan's launch. It is structured around prevention, early detection, diagnosis and treatment and quality of life of cancer patients and survivors and built on 10 flagship initiatives that cover: new technologies, research and innovation; sustainable cancer prevention; improving early detection; ensuring high standards in care; improving quality of life; reducing cancer equalities; and enhancing the focus on childhood cancer.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.62
Hidetoshi Nagai
Myoelectric refers to the use of electricity generated by muscles and is harnessed in the development of electrically powered prostheses, which are controlled by electromyographic (EMG) signals created in the residual musculature. Assistant professor Hidetoshi Nagai, Department of Artificial Intelligence, Kyushu Institute of Technology, Japan, is interested in surface myoelectric signals and is working on a project to develop technology that can advance their use. Nagai will capture motor unit activities using surface electromyography, which is easy to measure during exercise, and use this as the basis for more detailed muscle activity analysis. The methods Nagai has developed require no special equipment, other than the ability to sample at frequencies of several tens of kHz, and only require a single channel, which indicates the potential for more sophisticated analysis when multiple channels of information are present. It is also a simple and lightweight process that can be executed in real time. Conventional analysis and evaluation of muscle activity cannot be performed from the perspective of motor unit activity but Nagai has built on the basic premise that given that muscle activity is the sum of motor unit activities, the analysis of muscle activity should be based on the analysis of motor unit activity. He will analyse the surface EMG signal from the viewpoint of its component waveform the motor unit waveform so that muscle activity analysis can be performed as it should be.
{"title":"Detailed muscle state analysis method based on real-time wavelet analysis of surface myoelectric potential","authors":"Hidetoshi Nagai","doi":"10.21820/23987073.2023.3.62","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.62","url":null,"abstract":"Myoelectric refers to the use of electricity generated by muscles and is harnessed in the development of electrically powered prostheses, which are controlled by electromyographic (EMG) signals created in the residual musculature. Assistant professor Hidetoshi Nagai, Department of Artificial Intelligence, Kyushu Institute of Technology, Japan, is interested in surface myoelectric signals and is working on a project to develop technology that can advance their use. Nagai will capture motor unit activities using surface electromyography, which is easy to measure during exercise, and use this as the basis for more detailed muscle activity analysis. The methods Nagai has developed require no special equipment, other than the ability to sample at frequencies of several tens of kHz, and only require a single channel, which indicates the potential for more sophisticated analysis when multiple channels of information are present. It is also a simple and lightweight process that can be executed in real time. Conventional analysis and evaluation of muscle activity cannot be performed from the perspective of motor unit activity but Nagai has built on the basic premise that given that muscle activity is the sum of motor unit activities, the analysis of muscle activity should be based on the analysis of motor unit activity. He will analyse the surface EMG signal from the viewpoint of its component waveform the motor unit waveform so that muscle activity analysis can be performed as it should be.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.55
Tetsuji Uemura
Professor Tetsuji Uemura is a Visiting Professor in the Division of Plastic and Reconstructive Surgery at Showa University and Clinical Professor in the Division of Plastic and Reconstructive Surgery at Saga University Hospital. He is an expert in plastic surgery working to develop techniques and treatments for patients with diabetic food diseases, such as foot ulcers and gangrene. Although there is broad agreement regarding the existence of tarsal tunnel syndrome (TTS), there are still differences of opinion regarding its epidemiology as an etiology for foot pain and paresthesia, particularly in patients with diabetes. There is also still confusion regarding the best conservative treatment, timing of surgical intervention, best surgical approach, and management of recurrences. In Japan and ASEAN countries, more and more patients with diabetic foot disease need to have lower limb amputations due, in part, to a lack of medical specialists for diabetic foot diseases. Uemura wants to help overcome this by harnessing his interest in chronic nerve compression of the tibial nerve inside the tarsal tunnel, caused by diabetes and how this can be treated and prevented. Five key themes for Uemura and his fellow researchers in the Department, known as SEEDs for the Project, are: Shaping the relationship between the progression of diabetic, neuropathy and changes in foot and gait; Establishing a simple and early diagnostic method for acute infections that lead to amputation; Establishing the effectiveness of prophylactic foot surgery for diabetic foot lesions, especially verifying the possibility of treatment to improve the neuropathy that causes diabetic foot lesions; and Developing shoes that effectively prevent the occurrence of diabetic foot lesions.
{"title":"Minimally invasive tibial nerve decompression procedure could improve QOL in DFU patients with TTS","authors":"Tetsuji Uemura","doi":"10.21820/23987073.2023.3.55","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.55","url":null,"abstract":"Professor Tetsuji Uemura is a Visiting Professor in the Division of Plastic and Reconstructive Surgery at Showa University and Clinical Professor in the Division of Plastic and Reconstructive Surgery at Saga University Hospital. He is an expert in plastic surgery working to develop techniques and treatments for patients with diabetic food diseases, such as foot ulcers and gangrene. Although there is broad agreement regarding the existence of tarsal tunnel syndrome (TTS), there are still differences of opinion regarding its epidemiology as an etiology for foot pain and paresthesia, particularly in patients with diabetes. There is also still confusion regarding the best conservative treatment, timing of surgical intervention, best surgical approach, and management of recurrences. In Japan and ASEAN countries, more and more patients with diabetic foot disease need to have lower limb amputations due, in part, to a lack of medical specialists for diabetic foot diseases. Uemura wants to help overcome this by harnessing his interest in chronic nerve compression of the tibial nerve inside the tarsal tunnel, caused by diabetes and how this can be treated and prevented. Five key themes for Uemura and his fellow researchers in the Department, known as SEEDs for the Project, are: Shaping the relationship between the progression of diabetic, neuropathy and changes in foot and gait; Establishing a simple and early diagnostic method for acute infections that lead to amputation; Establishing the effectiveness of prophylactic foot surgery for diabetic foot lesions, especially verifying the possibility of treatment to improve the neuropathy that causes diabetic foot lesions; and Developing shoes that effectively prevent the occurrence of diabetic foot lesions.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.43
Maki Tsujita
Too much cholesterol can lead to health problems but cholesterol on high-density lipoprotein (HDL-C) is sometimes referred to as `good´ cholesterol because it is inversely related to cardiovascular disease risk. Junior Associate Professor Maki Tsujita, Department of Biochemistry, Nagoya City University, Japan, is leading a team of researchers conducting studies on the novel high-density lipoprotein (HDL) cholesterol excretion mechanism with a view to obtaining new insights on the link between lipid metabolism and diet. Cholesterol biosynthesis involves more than 30 biosynthetic steps and the body has an efficient absorption mechanism to acquire it from the diet via NPC1L1 in the small intestine. The cholesteryl ester transfer protein (CETP) acts as a key recycling mechanism for cholesterol that mediates the equilibrium of cholesteryl esters (CE), limiting cholesterol excretion. The focus of Tsujita's research is on the movement of free-cholesterol molecules and examining its excretion from the body. Tsujita' wants to clarify whether it is CE or free cholesterol that the SR-B1 receptor takes into the cell when it binds HDL, in order to better understand the details of the metabolism of cholesterol. In her current study, she is using a new approach to investigating the origin of free cholesterol in plasma and has found that radiolabelled FCs are increased in SR-BI deficient mice compared to wild-type mice, suggesting that the conversion of CE to FCs is occurring in the blood.
{"title":"Research on novel HDL cholesterol excretion mechanism","authors":"Maki Tsujita","doi":"10.21820/23987073.2023.3.43","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.43","url":null,"abstract":"Too much cholesterol can lead to health problems but cholesterol on high-density lipoprotein (HDL-C) is sometimes referred to as `good´ cholesterol because it is inversely related to cardiovascular disease risk. Junior Associate Professor Maki Tsujita, Department of Biochemistry, Nagoya City University, Japan, is leading a team of researchers conducting studies on the novel high-density lipoprotein (HDL) cholesterol excretion mechanism with a view to obtaining new insights on the link between lipid metabolism and diet. Cholesterol biosynthesis involves more than 30 biosynthetic steps and the body has an efficient absorption mechanism to acquire it from the diet via NPC1L1 in the small intestine. The cholesteryl ester transfer protein (CETP) acts as a key recycling mechanism for cholesterol that mediates the equilibrium of cholesteryl esters (CE), limiting cholesterol excretion. The focus of Tsujita's research is on the movement of free-cholesterol molecules and examining its excretion from the body. Tsujita' wants to clarify whether it is CE or free cholesterol that the SR-B1 receptor takes into the cell when it binds HDL, in order to better understand the details of the metabolism of cholesterol. In her current study, she is using a new approach to investigating the origin of free cholesterol in plasma and has found that radiolabelled FCs are increased in SR-BI deficient mice compared to wild-type mice, suggesting that the conversion of CE to FCs is occurring in the blood.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21820/23987073.2023.3.29
Takafumi Miyamoto
At the Department of Endocrinology, Metabolism and Diabetes, Institute of Medicine, University of Tsukuba, a team led by Assistant Professor Takafumi Miyamoto are performing investigations to promote personalised nutrition solutions by developing technology to correctly regulate processes that occur at the cellular level. The researchers want to fill knowledge gaps and better understand how different factors impact health and well-being. Their diverse investigations cover cancer metabolism, synthetic biology, digital biology integrating life science and Artificial Intelligence (AI) technology; personalised nutrition; and organelle code, all with the goal of creating a ´well-being` society. Lifestyle-induced diseases are on the rise and, by better understanding the complexities of diet and how it is related to well-being, Miyamoto and the team want to bring about a ´paradigm shift` in society. As such, studies including the visualisation of biological information encoded in blood, AI nutrition and epidemiological studies on food and health, are underway. Miyamoto believes that personalised nutrition will be the catalyst for establishing a society where food, education and medical care serve as social common capital locally. The researchers are developing novel biomolecular technologies and devices which foster physical wellness, including technology to correctly regulate the process of information processing at the cellular level. This involves research in synthetic biology. The team is currently fabricating wearable apparatus that can provide detailed information to deliver personalised nutrition.
{"title":"Integrated analysis of the diverse information modalities spun by mitochondrial morphology","authors":"Takafumi Miyamoto","doi":"10.21820/23987073.2023.3.29","DOIUrl":"https://doi.org/10.21820/23987073.2023.3.29","url":null,"abstract":"At the Department of Endocrinology, Metabolism and Diabetes, Institute of Medicine, University of Tsukuba, a team led by Assistant Professor Takafumi Miyamoto are performing investigations to promote personalised nutrition solutions by developing technology to correctly regulate processes that occur at the cellular level. The researchers want to fill knowledge gaps and better understand how different factors impact health and well-being. Their diverse investigations cover cancer metabolism, synthetic biology, digital biology integrating life science and Artificial Intelligence (AI) technology; personalised nutrition; and organelle code, all with the goal of creating a ´well-being` society. Lifestyle-induced diseases are on the rise and, by better understanding the complexities of diet and how it is related to well-being, Miyamoto and the team want to bring about a ´paradigm shift` in society. As such, studies including the visualisation of biological information encoded in blood, AI nutrition and epidemiological studies on food and health, are underway. Miyamoto believes that personalised nutrition will be the catalyst for establishing a society where food, education and medical care serve as social common capital locally. The researchers are developing novel biomolecular technologies and devices which foster physical wellness, including technology to correctly regulate the process of information processing at the cellular level. This involves research in synthetic biology. The team is currently fabricating wearable apparatus that can provide detailed information to deliver personalised nutrition.","PeriodicalId":13517,"journal":{"name":"Impact","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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