Integrative medicine最新文献

Background: A The author's comprehensive evaluation of the biochemical metabolomic literature over more than 40 years discusses multiple studies documenting abnormal elevations of the neurotransmitter dopamine and its metabolites as well as inhibitors of dopamine beta hydroxylase (DBH) from Clostridia bacteria in urine samples and cerebrospinal fluid samples of children with autism.

Aims of review: The evaluation intends to elucidate the reasons for the elevation of dopamine and its metabolites in urine and their relationship to increased Clostridia colonization of the gastrointestinal tract in children with autism. In addition, to the evaluation of Clostridia metabolism and its effects on abnormal dopamine metabolism in autism, a secondary aim intends to demonstrate as a hypothesis that one particular metabolite of Clostridia bacteria-3-hydroxy-(3-hydroxyphenyl)- 3-hydroxypropionic acid (HPHPA)-may cause even more severe effects on in autism than other metabolites by leading to depletion of free coenzyme A (CoASH). This depletion of free Coenzyme A leads to a deficiency of cholesterol and activated palmitic acid needed for activation of the key brain developmental protein sonic hedgehog, which has recently been research has shown to be severely abnormal in severe autism.

Key scientific concepts of review: Laboratories throughout the world have consistently found high quantities of HPHPA and 4-cresol in high percentages of urine samples of children with autism. Those inhibitors, which intestinal Clostridia bacteria produce, cause an elevation in dopamine and its metabolites, which affect the brain's and the sympathetic nervous system's key enzyme dopamine-beta-hydroxylase (DBH). Excessive dopamine and its toxic metabolites due to these DBH inhibitors may cause brain damage due to excessive unstable dopamine quinones, toxic adducts of dopamine disrupting brain mitochondrial energy production, and oxygen superoxide. HPHPA, a short chain phenyl compound, may have additional biochemical effects on the brain in autism, causing a reduction in free CoASH needed to produce the CoA palmitic acid derivative necessary to activate the key brain developmental protein sonic hedgehog. The depletion of CoASH appears to be a new therapeutic target to reverse the adverse effects of the HPHPA metabolite on the beta oxidation of fatty acids and cholesterol synthesis that are prevalent in autism.

Conclusions: Variations in the severity of autism could be based on the types and concentrations of the Clostridia markers produced and the extent to which these markers, such as HPHPA, have depleted critical lipids, such as cholesterol and CoA palmitic acid derivative. Patients need those lipids for the activation of the developmental protein sonic hedgehog. In addition, the sequestration of coenzyme A by short chain adducts of Clostridia leads to the depletion of critical free CoASH, n

The relentlessly increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) represents yet another chronic disease epidemic. Why have so many chronic diseases become so common? This editorial discusses NAFLD in the context of a few of the factors that underlie so much of chronic disease: excessive fructose consumption; sedentary lifestyle; poor diet; body load of bisphenols, phthalates, per-/polyfluorinated substances, and polychlorobiphenyls; and several commonly prescribed drugs.

Introduction: This case report reviewed a female client with numerous pre-existing conditions linked to gastrointestinal (GI) dysbiosis and systemic inflammation. Gastrointestinal ailments such as acid reflux/gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS), inflammatory bowel disorder (IBD), and increased intestinal permeability ("leaky gut") are on the rise and growing according to current research. Adjunctive therapies appear safe and are increasing in their use with the management of these conditions.

Case presentation: A 39-year-old female, currently using H2-Receptor antagonists (H2R), presented with long-standing signs and symptoms of gastrointestinal (GI) ailments. A nutritional approach (ReNew Food Plan) focusing on client education, increased consumption of foods associated with reduced inflammation, and decreased consumption of processed foods was recommended. These recommendations were made to improve intestinal permeability, balance gut microbiota, and reduce reflux symptoms while decreasing dependency on H2-R medications, restoring regular bowel movements, and increasing immune function, including IgA levels. As a result of the adjustments, the client reported outcomes (CRO) indicated a reduction in signs and symptoms of her gastrointestinal (GI) and immune system ailments from severe and frequent to mild and occasional.

Conclusion: The ReNew Food Plan, a "food-first approach" integrated with other interventions, appeared to improve this client's gastrointestinal (GI) and immune system function safely and effectively. Further studies are needed, especially about the ReNew Food Plan to compare results and show how this specific food plan could work for others.

In the late 1800s, treatment with thyroid extract caused dramatic improvement in patients with myxedema. Shortly thereafter, multiple other glandular extracts became available, both individually and in combinations. Their use gradually fell into disfavor, partly due to overpromotion by the manufacturers. The history of the use of thyroid, pancreatic, adrenal, thymus and liver extracts suggests that glandular extracts can be beneficial, especially when potential mechanisms of action and methods of preparation are considered.

Bronchial asthma is a chronic airway inflammatory condition associated with wheezing, tightness of the chest, breathlessness, and cough, leading to a reduction in quality of life. Conceptional vessel 17 (danzong) is the influential acupuncture point for the respiratory system, widely used in Traditional Chinese Medicine in combination with moxibustion (thermal stimulation) to manage respiratory problems. A 39-year-old male with bronchial asthma underwent the thermal stimulation of CV 17 acupuncture point 20 minutes daily for a period of 14 days. His pulmonary function was assessed at baseline and after 14 days using a spirometer. Pulmonary function test results showed significant improvement in FEV1/FVC ratio, PEF 25-75%, and PEFR. Further studies are indicated to establish the efficacy of dangzong with thermal stimulation for bronchial asthma.

This paper discusses concerns with specific approaches in identifying and eliminating gastrointestinal (GI) pathogens, as well as detoxifying toxic metals, that may be misleading and harmful to a patient's health. These are non-scientific methods that claim to improve GI microbial balance and mineral nutritional status that persist in the nutritional and natural medicine market, and unfortunately many are actively promoted through specific products and protocols marketed by nutritional supplement companies that should know better. The potential toxicity and mucosal damage of the long-term use of aggressive laxative herbs such as Cascara sagrada, rhubarb and/or Senna, as well as potential adverse events from ingredients containing fulvic acids and/or humic acids are discussed.

Background: Alcohol use is prevalent and may be a risk factor for diverticulitis. Therapeutic interventions that support the elimination of addictive behaviors and reduce disease progression include diet, supplement, and psychosocial interventions.

Case presentation: This case report highlights a client with successful treatment of abscess, bowel blockage, and inflammation in a 54-yr-old Caucasian male using medical nutrition therapy while continuing conventional treatment as prescribed by his medical provider. Over the course of 85 days, his treatment was augmented with a high-phytonutrient, high-fiber, Mediterranean style diet. Alcohol was eliminated, caloric intake was increased, while emotional support, physical activity, and a multivitamin were added. Upon final follow-up, the client had a remarkable reduction in symptoms and addictive behaviors.

Conclusion: Diet, supplement, and psychosocial interventions may be useful in the management of inebriate patients with diverticulitis. Population-based clinical studies should be done to understand the role of these therapies.

Context: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some patients experience persistent symptoms for months to years. Patients who attribute chronic symptoms to Lyme disease commonly use herbal supplements. The complexity, variability in dose and formulation, and lack of data for these herbal compounds make it difficult to assess their efficacy and safety.

Objective: This review examines the evidence for the antimicrobial activity, safety, and drug-drug interactions of 18 herbal supplements that patients commonly use for treatment of persistent symptoms attributed to Lyme disease.

Design: The research team performed a narrative review by searching the PubMed, Embase, Scopus, Natural Medicines databases, and NCCIH website. The search used the keywords for 18 herbal compounds: (1) andrographis (Andrographis paniculate), (2) astragalus (Astragalus propinquus), (3) berberine, (4) cat's claw bark (Uncaria tomentosa), (5) cordyceps (Cordyceps sinensis), (6) cryptolepis (Cryptolepis sanguinolenta), (7) Chinese skullcap (Scutellaria baicalensis), (8) garlic (Allium sativum), (9) Japanese knotwood (Polygonum cuspidatum), (10) reishi mushrooms (Ganoderma lucidum), (11) sarsaparilla (Smilax medica), (12) Siberian ginseng (Eleutherococcus senticosus), (13) sweet wormwood (Artemisia annua), (14) teasle root (Dipsacus fullonum), (15) lemon balm (Melissa officinalis), (16) oil of oregano (Origanum vulgare), (17) peppermint (Mentha x piperita), and (18) thyme (Thymus vulgaris). The team also searched for terms related to protocols, including Dr. Rawls' protocol and the Buhner protocol.

Setting: University of Maryland Medical Center, Baltimore MD.

Results: Seven of the 18 herbs reviewed had evidence for in-vitro activity against B. burgdorferi. These compounds included: (1) cat's claw (2) cryptolepis, (3) Chinese skullcap, (4) Japanese knotweed, (5) sweet wormwood, (6) thyme, and (7) oil of oregano. With the exception of oil of oregano these compounds also have anti-inflammatory activity. In vivo data and clinical trials are lacking. Clinicians should be cautious as many of the identified compounds have drug interactions and additive effects that could lead to increased risks for bleeding, hypotension, and hypoglycemia.

Conclusions: Many of the herbs that alternative and integrative practitioners use to treat Lyme disease have anti-inflammatory effects that may contribute to patients' perceptions of symptomatic improvement. Some herbs have limited demonstrated anti-borrelial activity in vitro, but in-vivo data and clinical trial data is lacking. Further research is required to determine the efficacy, safety and appropriate use of these herbs for this patient population.