Integrative medicine最新文献

It is difficult to overstate the importance of glutathione because it performs many critical biological functions. The purpose of this article is to briefly review glutathione's functions, explain why most people have low levels of glutathione and make the case that increasing glutathione levels is one of the most important pro-active steps people can take to improve their health and slow down the onset of age-related diseases. This article will also introduce practitioners to Lactobacillus fermentum ME-3, which is a unique strain of probiotic bacteria that synthesizes glutathione.

It was more than 70 years ago that Linus Pauling identified sickle cell anemia as a molecular disease associated with alteration in oxygen metabolism in the red blood cell due to the monogenetic substitution of a single amino acid in hemoglobin. It's been 50 years since he first wrote about the concept of Orthomolecular Medicine, which focuses on adjusting the physiological levels of molecules with nutrient-derived precursors (now termed nutraceuticals) to promote optimal health. We now see these concepts being applied in the nutraceutical management of sickle cell anemia using glutamate as a precursor of glutathione and other conditions associated with oxidative stress.

Vitamin D is critical for many physiological functions in humans. Numerous population-wide assessments have shown that vitamin D deficiency is very common. Unfortunately, far too many studies intending to assess the clinical efficacy of supplementation are poorly designed. They look at vitamin D as an isolated agent, independent of the complex matrix required for it to be physiologically effective and at dosages inadequate for much of the population. These errors cause inappropriate and invalid results that are then misused to not only recommend against supplementation but to also recommend against even measuring vitamin D levels. This editorial addresses the weaknesses of typical vitamin D research, such as VITAL, and the key factors that must be addressed for accurate vitamin D research.

Exposure to environmental toxins contributes to both acute and chronic illnesses, and is of growing concern. The importance of the microbiome to gastrointestinal (GI), as well as systemic health, has been the topic of much research recently. The microbiome influences health, and can either be a source of beneficial metabolites, or contribute to poor health. Dysbiosis, particularly in the GI tract, or oral cavity is a source of endogenously produced toxicity in the form of proinflammatory mediators-most notably lipopolysaccharide (LPS). LPS is cleared by the liver from enterohepatic circulation, and contributes to its workload. Bacterial overgrowth has been shown to be a contributing factor to liver disease. Further influences of the microbiome on detoxification include the Gut-Liver axis and biofilm production. Botanicals can have beneficial effects on microbial balance, favoring probiotic abundance, while addressing pathogen load. Additionally, plants offer antioxidant, biofilm disruption, antiinflammatory and immunomodulatory activities. Inclusion of botanical medicine to modulate the microbiome is a novel therapeutic target to reduce endogenously produced toxins and total toxic load.

Context: Age-related declines in immune system function, including vaccine responsiveness, are well established. Dietary and lifestyle factors have been investigated in human clinical trials and observational studies for their effects on vaccine response.

Objective: The review intended to assess dietary and lifestyle factors that can modulate vaccine response in a population aged 55 years or older or in a population with an average age of 55 years or older.

Design: The research team performed a narrative review of studies occurring up until May 2021 by searching electronic PubMed databases.

Results: The review findings suggest that two factors may have clinically relevant effects on vaccine response: regular aerobic exercise and psychological environmental stressors, in particular caregiving stress, which studies have consistently found can have a positive and negative effect or association, respectively. In addition, micronutrients used in combination as well as microbiome-targeted interventions show mostly promising results. Other factors may yet be relevant but very few studies have been done.

Conclusions: Heterogeneity of study design, small sample sizes, and other challenges mean that strong conclusions remain elusive. Further study is needed as well as improvements in study design. However, there are indications that certain dietary and lifestyle factors influence vaccine effectiveness.

While Cushing syndrome is rare, but well-recognized, subclinical hypercortisolism (defined as excessive cortisol secretion without the classic manifestations of Cushing syndrome) is significantly more common. Subclinical hypercortisolism contributes to several chronic diseases, such as diabetes, osteoporosis, sarcopenia and hypertension. The incidence increases with age and correlates with body load of environmental toxins such as bisphenol A (BPA). This editorial discusses prevalence, contribution to disease, causes, diagnosis, and intervention.