C. Agrawal, K. Das, S. Verma, N. Shirazi, Mansi Kala
The study describes a case of hyper-eosinophilia who was presented with overt manifestation of high eosinophil and detected to have underlying non Hodgkin lymphoma. The male patient was presented with profound weakness and multiple non itchy nodular skin lesion for 2 weeks. Biopsy from skin nodule showed deposits of abnormal lymphocytes. Lymph node biopsy showed effacement with mono nuclear abnormal cells which showed positivity for CD4 and 5, negative for cytokeratin and CD20. He was diagnosed to have T-NHL. [Fig. 3a, Fig. 3b] Bone marrow showed involvement by NHL cells. His diplopia and headache responded to intra-thecal methotrexate and possibly CNS involvement of disease was considered. Family opted out of allopathic treatment plan due to clinical progression. He later died of disease progression. This case illustrates the rare and interesting association of overt clinical hyper-eosinophilia and T NHL. The study suggests that cases with hyper eosinophilia should be evaluated thoroughly for T cell disease. Case Report Agrawal et al.; IBRR, 9(1): 1-5, 2019; Article no.IBRR.45392 2
{"title":"Overt Clinical Hypereosinophilia in T- cell Non Hodgkin Lymphoma: A Case Report","authors":"C. Agrawal, K. Das, S. Verma, N. Shirazi, Mansi Kala","doi":"10.9734/IBRR/2019/45392","DOIUrl":"https://doi.org/10.9734/IBRR/2019/45392","url":null,"abstract":"The study describes a case of hyper-eosinophilia who was presented with overt manifestation of high eosinophil and detected to have underlying non Hodgkin lymphoma. The male patient was presented with profound weakness and multiple non itchy nodular skin lesion for 2 weeks. Biopsy from skin nodule showed deposits of abnormal lymphocytes. Lymph node biopsy showed effacement with mono nuclear abnormal cells which showed positivity for CD4 and 5, negative for cytokeratin and CD20. He was diagnosed to have T-NHL. [Fig. 3a, Fig. 3b] Bone marrow showed involvement by NHL cells. His diplopia and headache responded to intra-thecal methotrexate and possibly CNS involvement of disease was considered. Family opted out of allopathic treatment plan due to clinical progression. He later died of disease progression. This case illustrates the rare and interesting association of overt clinical hyper-eosinophilia and T NHL. The study suggests that cases with hyper eosinophilia should be evaluated thoroughly for T cell disease. Case Report Agrawal et al.; IBRR, 9(1): 1-5, 2019; Article no.IBRR.45392 2","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87457529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple Myeloma Relapse Presenting as Unilateral Blindness","authors":"Amit Badola, T. Khanna, Kunal, S. Verma","doi":"10.9734/IBRR/2018/45424","DOIUrl":"https://doi.org/10.9734/IBRR/2018/45424","url":null,"abstract":"","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77252552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maimuna Khatoon, J. Bindal, D. Sharma, P. Gupta, A. S. Tomar, K. Saify, Rakesh K. Gupta
Background: Umbilical cord blood is whole human blood (60 to 80 ml) that remains in the placenta and umbilical cord after childbirth; generally considered as a medical waste. It is a rich source of stem cells, growth factor, cytokines, etc., and, can be collected, stored and utilized in the treatment of incurable diseases. Aims and Objects: The aim of the present study is to establish the fact that placental umbilical cord whole blood is a safe alternative to adult blood and to assess its utility in degenerative and autoimmune disease along with its hematological parameters. Materials and Methods: It is a prospective two year study (From September 2016 to August 2018) of 250 umbilical cord whole blood transfusions in autoimmune and degenerative disorders at Gajra Raja Medical College, Gwalior, India. Follow up of patients was done up to 3 months and data was collected and analyzed statistically by frequency distribution and percentage proportion. Original Research Article Khatoon et al.; IBRR, 8(4): 1-9, 2018; Article no.IBRR.45260 2 Results: A total of 250 units meeting the inclusion and exclusion criteria were transfused to 99 preregistered patients; Vitiligo 61 (159 transfusions), Thalassemia 15 (30), Retinitis Pigmentosa 9 (23), Geriatric Disorders 9 (24), Aplastic anemia 4 (9) and High Myopia 1 (5). Out of 250 transfusions, in one case (0.4%) adverse event was reported. Outcome of transfusion reveals; In Vitiligo –regimentation in affected area, Thalassemia-reduction in frequency of transfusions, Retinitis Pigmentosaimprovement in vision area, Geriatric patientssense of well being, Aplastic anemiaprolonged survival and High Myopia-improvement in vision area. Conclusion: Umbilical cord blood is safe and genuine alternative of adult blood. It is effective in degenerative and autoimmune diseases. It should not be discarded as medical waste and utilized judiciously in the human well being.
{"title":"Utility of Placental Umbilical Cord Blood in Autoimmune and Degenerative Disorders","authors":"Maimuna Khatoon, J. Bindal, D. Sharma, P. Gupta, A. S. Tomar, K. Saify, Rakesh K. Gupta","doi":"10.9734/IBRR/2018/45260","DOIUrl":"https://doi.org/10.9734/IBRR/2018/45260","url":null,"abstract":"Background: Umbilical cord blood is whole human blood (60 to 80 ml) that remains in the placenta and umbilical cord after childbirth; generally considered as a medical waste. It is a rich source of stem cells, growth factor, cytokines, etc., and, can be collected, stored and utilized in the treatment of incurable diseases. Aims and Objects: The aim of the present study is to establish the fact that placental umbilical cord whole blood is a safe alternative to adult blood and to assess its utility in degenerative and autoimmune disease along with its hematological parameters. Materials and Methods: It is a prospective two year study (From September 2016 to August 2018) of 250 umbilical cord whole blood transfusions in autoimmune and degenerative disorders at Gajra Raja Medical College, Gwalior, India. Follow up of patients was done up to 3 months and data was collected and analyzed statistically by frequency distribution and percentage proportion. Original Research Article Khatoon et al.; IBRR, 8(4): 1-9, 2018; Article no.IBRR.45260 2 Results: A total of 250 units meeting the inclusion and exclusion criteria were transfused to 99 preregistered patients; Vitiligo 61 (159 transfusions), Thalassemia 15 (30), Retinitis Pigmentosa 9 (23), Geriatric Disorders 9 (24), Aplastic anemia 4 (9) and High Myopia 1 (5). Out of 250 transfusions, in one case (0.4%) adverse event was reported. Outcome of transfusion reveals; In Vitiligo –regimentation in affected area, Thalassemia-reduction in frequency of transfusions, Retinitis Pigmentosaimprovement in vision area, Geriatric patientssense of well being, Aplastic anemiaprolonged survival and High Myopia-improvement in vision area. Conclusion: Umbilical cord blood is safe and genuine alternative of adult blood. It is effective in degenerative and autoimmune diseases. It should not be discarded as medical waste and utilized judiciously in the human well being.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77186576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Arita, Mitsuhiro Fukata, T. Maruyama, K. Odashiro, T. Fujino, Chizuko Wakana, Aya Sato, Kazue Takahashi, Yoshiko Iida, S. Mawatari, K. Akashi
{"title":"Comparison of Human Erythrocyte Filterability with Trapping Rate Obtained by Nickel Mesh Filtration Technique: Two Independent Parameters of Erythrocyte Deformability","authors":"T. Arita, Mitsuhiro Fukata, T. Maruyama, K. Odashiro, T. Fujino, Chizuko Wakana, Aya Sato, Kazue Takahashi, Yoshiko Iida, S. Mawatari, K. Akashi","doi":"10.9734/IBRR/2018/44667","DOIUrl":"https://doi.org/10.9734/IBRR/2018/44667","url":null,"abstract":"","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88037198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Investigation of the Effects of Different Aqueous Preparations of Hibiscus sabdariffa (Zobo Drinks) on Haematological Parameters in Normal Wistar Albino Rats","authors":"C. N. Chukwu, C. C. Ikewuchi, J. Akaninwor","doi":"10.9734/IBRR/2018/26076","DOIUrl":"https://doi.org/10.9734/IBRR/2018/26076","url":null,"abstract":"","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91110949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Akaba, M. Inyama, T. Ekwere, O. Iheanacho, Ekpeyong Bassey, U. Godwin, Hogan Archibong, E. Efiok
Background: Sickle cell disease (SCD) is an autosomal recessive disorder that is characterised with chronic anaemia and painful crisis. SCD is associated with hypercoagulability or prothrombotic state that can predispose to thromboembolic complications with increasing morbidity and mortality. Aim: This study aimed to show the various documented haemostatic disorders and possible thromboembolic complications among SCD subjects in Nigeria. Methods: A comprehensive literature search was performed using the internet search engines linked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, Scopus, etc. Studies involving hemostatic disorders in Nigeria were thoroughly searched, and the references of such articles were also searched for any probable relevant information. Review Article Akaba et al.; IBRR, 8(4): 1-7, 2018; Article no.IBRR.43929 2 Findings and Conclusion: There is a paucity of information on this subject in Nigeria, and there are inconsistencies in the available studies. Haemostatic disorders in sickle cell disease are conditions that are associated with increased mortality and morbidity. Further research on the level of natural anticoagulant is required to verify the correlation between haemostatic disorders and thromboembolic complications in SCD subjects in Nigeria.
{"title":"Haemostatic Disorders in Sickle Cell Disease Subjects in Nigeria: A Review of Literature","authors":"K. Akaba, M. Inyama, T. Ekwere, O. Iheanacho, Ekpeyong Bassey, U. Godwin, Hogan Archibong, E. Efiok","doi":"10.9734/IBRR/2018/43929","DOIUrl":"https://doi.org/10.9734/IBRR/2018/43929","url":null,"abstract":"Background: Sickle cell disease (SCD) is an autosomal recessive disorder that is characterised with chronic anaemia and painful crisis. SCD is associated with hypercoagulability or prothrombotic state that can predispose to thromboembolic complications with increasing morbidity and mortality. Aim: This study aimed to show the various documented haemostatic disorders and possible thromboembolic complications among SCD subjects in Nigeria. Methods: A comprehensive literature search was performed using the internet search engines linked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, Scopus, etc. Studies involving hemostatic disorders in Nigeria were thoroughly searched, and the references of such articles were also searched for any probable relevant information. Review Article Akaba et al.; IBRR, 8(4): 1-7, 2018; Article no.IBRR.43929 2 Findings and Conclusion: There is a paucity of information on this subject in Nigeria, and there are inconsistencies in the available studies. Haemostatic disorders in sickle cell disease are conditions that are associated with increased mortality and morbidity. Further research on the level of natural anticoagulant is required to verify the correlation between haemostatic disorders and thromboembolic complications in SCD subjects in Nigeria.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73156016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Mohamed, Maha A. Swani, Majdeddin. I. Alaghib, Abdeljawad I. Abdeljawad, Murad Alkezza, Mohamed Alobaidy
{"title":"Hematological Assessment of Benzene Exposure among Employees in Brega Oil Marketing Company (BOMC), Benghazi","authors":"H. Mohamed, Maha A. Swani, Majdeddin. I. Alaghib, Abdeljawad I. Abdeljawad, Murad Alkezza, Mohamed Alobaidy","doi":"10.9734/ibrr/2018/43266","DOIUrl":"https://doi.org/10.9734/ibrr/2018/43266","url":null,"abstract":"","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82538262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of DNMT3A Gene Mutation on Response of Acute Myeloid Leukemia Patients to Induction Therapy","authors":"Dina G. Segai, N. Ramsis, H. Fahmy, Noha Kamel","doi":"10.9734/IBRR/2018/44030","DOIUrl":"https://doi.org/10.9734/IBRR/2018/44030","url":null,"abstract":"","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76944478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Tula, O. Iyoha, R. Okojie, J. Filgona, G. Onyeje
Aim: To determine the level of Salmonella agglutinin and its titre among apparently healthy students of Tertiary Institution in North-eastern Nigeria. Study Design: A cross-sectional study on Seroprevalence of Salmonella agglutinin; Place and Duration of the Study: Department of Biological Science Technology, Federal Polytechnic Mubi, Adamawa State, between September to December, 2016. Methodology: This study was a cross-sectional study in which 200 apparently healthy students of Federal Polytechnic Mubi were tested for Salmonella agglutinin using both slide and tube agglutination methods. Original Research Article Tula et al.; IBRR, 8(3): 1-7, 2018; Article no.IBRR.43362 2 Statistical Analysis: Non-parametric Mann-Whitney statistics and least significance difference (LSD) were used to test for significant difference in all the data obtained. Significance difference was taken when P˂0.05. Results: The result showed that the number of male with positive Widal agglutinin was significantly higher than that of female (P=0.028). The number of positive titre was significantly higher in age group 21-25 years (P=0.002) when compared to other age brackets. However, there was no statistical difference between the age bracket 16-20 years and 31-35 years (P=0.747). The result of the agglutination titre showed that more male had Salmonella titre for Salmonella Typhi O (81.8%) and Salmonella Typhi H (72.7%) while more female had Salmonella agglutinin titre for Salmonella Typhi H (44.4%) and Salmonella Paratyphi B-H (33.3%). It was also observed that only agglutinin for Salmonella Paratyphi A-O, B-O, C-O, B-H and C-H were present in the sera of male subjects up to the titre of 160 and at frequencies ranging from 1.6-58.8%. Furthermore, among females, it was observed that only agglutinins for Salmonella Paratyphi A-O, Salmonella Typhi C-H and Salmonella Typhi O and H were present in the sera of the subjects up to the titre of 160 and at frequencies ranging from 2.5-25.0%. Conclusion: Detecting Salmonella agglutinin titre up to 160 among apparently healthy individuals is of public health significance. Thus, there is need to monitor this trend and create awareness on environmental and behavioural risk factors for Salmonella infections.
{"title":"Seroprevalence of Salmonella Agglutinins among Apparently Healthy Students of a Tertiary Institution in North-Eastern Nigeria","authors":"M. Tula, O. Iyoha, R. Okojie, J. Filgona, G. Onyeje","doi":"10.9734/IBRR/2018/43362","DOIUrl":"https://doi.org/10.9734/IBRR/2018/43362","url":null,"abstract":"Aim: To determine the level of Salmonella agglutinin and its titre among apparently healthy students of Tertiary Institution in North-eastern Nigeria. Study Design: A cross-sectional study on Seroprevalence of Salmonella agglutinin; Place and Duration of the Study: Department of Biological Science Technology, Federal Polytechnic Mubi, Adamawa State, between September to December, 2016. Methodology: This study was a cross-sectional study in which 200 apparently healthy students of Federal Polytechnic Mubi were tested for Salmonella agglutinin using both slide and tube agglutination methods. Original Research Article Tula et al.; IBRR, 8(3): 1-7, 2018; Article no.IBRR.43362 2 Statistical Analysis: Non-parametric Mann-Whitney statistics and least significance difference (LSD) were used to test for significant difference in all the data obtained. Significance difference was taken when P˂0.05. Results: The result showed that the number of male with positive Widal agglutinin was significantly higher than that of female (P=0.028). The number of positive titre was significantly higher in age group 21-25 years (P=0.002) when compared to other age brackets. However, there was no statistical difference between the age bracket 16-20 years and 31-35 years (P=0.747). The result of the agglutination titre showed that more male had Salmonella titre for Salmonella Typhi O (81.8%) and Salmonella Typhi H (72.7%) while more female had Salmonella agglutinin titre for Salmonella Typhi H (44.4%) and Salmonella Paratyphi B-H (33.3%). It was also observed that only agglutinin for Salmonella Paratyphi A-O, B-O, C-O, B-H and C-H were present in the sera of male subjects up to the titre of 160 and at frequencies ranging from 1.6-58.8%. Furthermore, among females, it was observed that only agglutinins for Salmonella Paratyphi A-O, Salmonella Typhi C-H and Salmonella Typhi O and H were present in the sera of the subjects up to the titre of 160 and at frequencies ranging from 2.5-25.0%. Conclusion: Detecting Salmonella agglutinin titre up to 160 among apparently healthy individuals is of public health significance. Thus, there is need to monitor this trend and create awareness on environmental and behavioural risk factors for Salmonella infections.","PeriodicalId":13659,"journal":{"name":"International Blood Research & Reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84902331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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