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Synthesis and toxicity test of 2’-hydroxy-5’-chloro-3,4-dymethoxychalcone 2′-羟基-5′-氯-3,4-甲氧基查尔酮的合成及毒性试验
Pub Date : 2021-09-28 DOI: 10.1063/5.0059535
Melia Mulyani, Harra Ismi Farah, Rolan Rusli, Agung Rahmadani
This study was aimed to synthesis the chalcone derivative and tested its toxicity. Synthesis of 2’-hydroxy-5’-chloro-3,4-dimethoxychalcone carried out through Claisen-Schmidt condensation at room temperature. The toxicity test prepared by Brine Shrimp Lethality Test (BSLT) to Artemia Salina L. Analysis retrosynthetic gives the 2-hydroxy-5-chloro acetophenone and 3,4-dimethoxy benzaldehyde as starting materials. The desire chalcone was confirmed by 1H and 13C NMR, also mass spectroscopy. The chalcone obtained in 83.27% and exhibited LC50 value in 974.99 µg/mL.
本研究旨在合成查尔酮衍生物并测试其毒性。采用clisen - schmidt缩合法在室温下合成了2′-羟基-5′-氯-3,4-二甲氧基查尔酮。采用卤虾致死性试验(BSLT)制备了对盐蒿的毒性试验。分析以2-羟基-5-氯苯乙酮和3,4-二甲氧基苯甲醛为起始原料。愿望查尔酮经1H、13C核磁共振和质谱证实。查尔酮的提取率为83.27%,LC50值为974.99µg/mL。
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引用次数: 0
Magnetic field distribution of silver blood cancer with finite difference time domain (FDTD) simulation 银屑病血癌磁场分布时域有限差分模拟
Pub Date : 2021-09-28 DOI: 10.1063/5.0060184
V. Z. Zulfa, U. Farahdina, M. Firdhaus, I. Aziz, Nasori, Darsono, A. Rubiyanto
The protein contained in blood cancer is more than normal blood cells. This can be used as a parameter to determine the refractive index of a cell. The refractive index can affect the value of the magnetic field that can be received or transmitted. A time domain approach using normal blood cells and blood cells was analyzed. In this simulation electrode with difference size is used. The visible light with 200-800 nm wavelength is emitted in electrode surface to study the magnetic field. The results of this study are expected to provide interpretation of blood cancer using the nanostructured Ag sensor.
血癌中所含的蛋白质比正常血细胞要多。这可以作为一个参数来确定一个电池的折射率。折射率可以影响可以接收或传输的磁场值。对正常血细胞和血细胞的时域方法进行了分析。在这个模拟中,使用了不同尺寸的电极。在电极表面发射200 ~ 800nm波长的可见光,对磁场进行研究。这项研究的结果有望为使用纳米结构银传感器的血癌提供解释。
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引用次数: 0
Current control of brushless DC motor using common DC signal for electric vehicle 用普通直流信号控制电动汽车无刷直流电动机电流
Pub Date : 2021-09-28 DOI: 10.1063/5.0066364
U. Neethu, N. Karthick, S. Dasgupta, S. Deepu
This present study proposes a current controlled modulation method for brushless DC motors for electric vehicle. A quasi-square current control technique is used. Conventional controllers such as PI, PID controllers are used first, then the system is evaluated using Fuzzy Logic controller which further improves the system and also fuzzy controller is far better than other controllers due to the use of linguistic terms.
提出了一种电动汽车用无刷直流电机的电流控制调制方法。采用了准平方电流控制技术。首先使用PI、PID等传统控制器,然后使用模糊逻辑控制器对系统进行评估,模糊逻辑控制器进一步改进了系统,并且模糊控制器由于使用了语言术语而远远优于其他控制器。
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引用次数: 0
Antidiabetic activity of Jering skin extract (Pithecellobium jiringa) with dichloromethane (DCM) solvent fraction 二氯甲烷(DCM)溶剂提取物的抗糖尿病活性
Pub Date : 2021-09-28 DOI: 10.1063/5.0059477
A. Surya, D. P. Mahardika, Zaiyar, Harni Sepriani
Jering skin is a solid waste that can cause problems to the environment if it is not treated seriously. Based on previous research, Jering skin contains highly flavonoids and polyphenols source which potentially used as an antiseptic and anticancer agent. The study aims to evaluate Jering skin antidiabetic activities using varieties DCM solvent fraction. The microplate reader analysis at 410 nm wavelength was used to measure an absorbance level of the Inhibitor Concentration 50 (IC50) sample extracts which inhibited by the α-glucosidase enzyme when hydrolyzing the p-nitrophenyl substrate α-D-glucopyranoside (p-NPG) to form a glucose molecules. As a result, the Jering skin extract is shown to be an alternative antidiabetic agent in the future, with the IC50 level at 417.381 µg/mL.
刺激皮肤是一种固体废物,如果不认真对待,会对环境造成问题。根据以往的研究,金莲皮含有高含量的黄酮类化合物和多酚类物质,具有潜在的防腐和抗癌作用。本研究旨在评价不同品种DCM溶剂提取物的抗糖尿病活性。采用410 nm波长的微孔板分析,测定α-葡萄糖苷酶抑制抑制剂浓度50 (IC50)样品提取物水解对硝基苯底物α- d -葡萄糖苷(p-NPG)生成葡萄糖分子时的吸光度水平。因此,Jering skin提取物在未来被证明是一种替代的降糖药,其IC50水平为417.381µg/mL。
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引用次数: 0
Ants as a climate change bioindicator in Sirimau Forest at Ambon Island 安汶岛Sirimau森林中蚂蚁作为气候变化生物指标的研究
Pub Date : 2021-09-28 DOI: 10.1063/5.0059861
F. latumahina
The destruction of forests on small islands is caused by disturbance of human activities such as forest burning, flooding, erosion, rock-taking, sand and clearing of forest areas for agriculture, plantation, settlement and other public facilities. Ants are organisms that can react when there is a change in their habitat. Because of its abundance, its important functions, and complex interactions with the ecosystems it occupies. Ants can be used as bioindicators in environmental assessment programs, such as forest fires, vegetation disruption, deforestation, climate change, mining, waste disposal, and land use factors. Ants are capable of marking environmental degradation and climate change, as they are very sensitive to climate change in their habitats. The study was conducted on the Sirimau Forest at Ambon. The role of ants in the ecosystem will be disrupted when habitat changes occur, so this study aims to find out the forms of introduction that occur in the forest area on the island of Ambon, how ants react to climate change, ant diversity and examine the role of ants as an indicator of climate change. Approaches are made to biotic components (vegetation and ants) as well as abiotic components (soil temperature, air temperature and air humidity). The results of the field inventory found 28 types of ants, 3152 individuals where Odonthoponera tranversa infuscate, Oecophylla smaragdina SUENITIDA, Hypoponera bugnioni are dominant with a species richness value of 3.35, 3.57 species density and 1.29 species diversity with an NOVI value with a vegetation cover area of > 60% in classes 6-9. The highest vegetation diversity was 1.17. Studies at soil temperatures and organic matter content show that soil temperatures vary between 25-27 °C and this is correlated with the area of vegetation cover shown in the NOVI results. The impact of damage and changes to the protected forest ecosystem on ants varies widely. Ants are colonized animals that will die due to changes or damage to the ecosystem, of course it can be explained as colony extinction in the ecosystem.
小岛屿森林的破坏是由于人类活动的干扰造成的,如森林燃烧、洪水、侵蚀、采石、采沙以及为农业、种植园、定居和其他公共设施而清除林区。蚂蚁是一种生物,当它们的栖息地发生变化时,它们会做出反应。因为它的丰富,它的重要功能,以及与它所占据的生态系统的复杂相互作用。蚂蚁可以作为环境评价项目的生物指标,如森林火灾、植被破坏、森林砍伐、气候变化、采矿、废物处理和土地利用等因素。蚂蚁对其栖息地的气候变化非常敏感,因此能够标记环境退化和气候变化。这项研究是在安汶的Sirimau森林进行的。当栖息地发生变化时,蚂蚁在生态系统中的作用会被破坏,因此本研究旨在了解安汶岛森林地区发生的引进形式,蚂蚁对气候变化的反应,蚂蚁的多样性,以及蚂蚁作为气候变化指标的作用。方法是对生物成分(植被和蚂蚁)以及非生物成分(土壤温度,空气温度和空气湿度)。野外清查结果显示,6 ~ 9类蚁群共有28种3152只,其中以灌花齿齿蚁、smaragdina Oecophylla SUENITIDA、bugnionia小齿齿蚁占优势,物种丰富度值为3.35,物种密度值为3.57,物种多样性值为1.29,NOVI值为0.60 %,植被覆盖率为60%。植被多样性最高,为1.17。对土壤温度和有机质含量的研究表明,土壤温度在25-27℃之间变化,这与NOVI结果中显示的植被覆盖面积有关。受保护森林生态系统的破坏和变化对蚂蚁的影响差异很大。蚂蚁是一种会因生态系统的变化或破坏而死亡的群居动物,当然也可以解释为生态系统中的群体灭绝。
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引用次数: 0
Synthesis and anticancer, antidiabetic activity test of β-hydroxypicolinyl serine ethyl heptanoyl ester (PSEHE) β-羟基喹啉丝氨酸乙基庚烷酯的合成及抗癌、降糖活性试验
Pub Date : 2021-09-28 DOI: 10.1063/5.0060149
Edward J. Dompeipen
The novel compounds of β Hydroxypicolinyl serine ethyl heptanoyl ester (PSEHE) were obtained from modification of UK 3A compound that had been known possessing high activity as antifungal, antibacterial and anticancer. From this research it is expected to obtain UK 3A analogues compound that higher yield, more economic and hight activity. The purpose of this study was to synthesize PSEHE compounds which have anticancer and antidiabetic activity. The synthesis of these compounds were carried out in two step reactions. The first step was amidation L-serine ethyl ester hydrochloride with β hydroxypicolinyc acid to produce with β hydroxyl picolinyl serine ethyl ester (PSEE). The second step was esterification of β hydroxyl picolinyl serine ethyl ester with heptanoic acid used DCC and DMAP in chloroform to produce PSEHE. Preliminary analysis was carried out with thin layer chromatography (TLC) and followed by purification using extraction, and the column chromatography on silica gel, eluted with n-hexane and ethyl acetate. Subsequently synthesis product were identified using LCMS Spectrometry, FTIR spectrophotometer, 1H-NMR and 13C-NMR. The pure compound of PSEE from the first step was 85.22% and afterwards pure compound of PSEHE from the second step were 94.48%. The result of toxicity test using Brine Shrimp Lethality Test shown that PSEHE with value LC50 933.25 ppm. The results of cytotoxicity test using Murine Leukemia P-388 cells shown that PSEHE with value IC50 38.0 µg/mL and and the percentage inhibition against to α-glucosidase with value 88.7%.
通过对具有抗真菌、抗菌和抗癌活性的uk3a化合物进行修饰,得到了新的β羟基喹啉丝氨酸乙基庚烷酯(PSEHE)化合物。通过本研究有望获得收率更高、经济性更强、活性更强的英国3A类似物。本研究的目的是合成具有抗癌和抗糖尿病活性的PSEHE化合物。这些化合物的合成是通过两步反应进行的。第一步用β羟基吡啶酸酰胺化l -丝氨酸乙酯盐酸盐制得β羟基吡啶基丝氨酸乙酯(PSEE)。第二步,利用DCC和DMAP在氯仿中与庚酸酯化制备pshe。采用薄层色谱(TLC)进行初步分析,提取纯化,硅胶柱层析,正己烷和乙酸乙酯洗脱。合成产物经LCMS、FTIR、1H-NMR、13C-NMR鉴定。第一步所得PSEE的纯度为85.22%,第二步所得PSEHE的纯度为94.48%。卤虾毒力试验结果表明,pshe的LC50值为933.25 ppm。小鼠白血病P-388细胞的细胞毒实验结果表明,PSEHE的IC50值为38.0µg/mL,对α-葡萄糖苷酶的抑制率为88.7%。
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引用次数: 0
Future of electric vehicles with reference to national electric mobility mission plan at Tamil Nadu 参考泰米尔纳德邦国家电动交通任务计划的电动汽车的未来
Pub Date : 2021-09-28 DOI: 10.1063/5.0066282
S. Shrilatha, K. Aruna, Sunanda Bhagavathy, G. Chellaiah, Anirudh Gupta
In the past few decades the personal vehicle commutation has been increased in India due to their lifestyle changes and standard of living. The carbon emissions from the automobiles are the major cause of air pollution in the present world including India. The government and environmental safety organizations are thinking for alternate sources to reduce the pollution by encouraging the electric vehicles. Hence this study took the Sample Size of 112 at Tamil Nadu to analyze customer adoption towards Electric Vehiclesby adopting Convenient and Random sampling technique. The findings of this study revealed that the customer Prefer Hyundai Cars while shifting to Electric Car Variants. The customers shift to the Electric cars due to the benefit of Subsidy given by the Government for Loan and Tax. The customers hesitate to shift to the Electric Car because of less mileage. Thus, could not achieve Government's Electric Mission Plan 2020.
在过去的几十年里,由于生活方式的改变和生活水平的提高,印度的个人车辆通勤增加了。汽车的碳排放是包括印度在内的当今世界空气污染的主要原因。政府和环境安全机构正在考虑通过鼓励电动汽车来减少污染的替代能源。因此,本研究采用泰米尔纳德邦112个样本量,采用方便和随机抽样技术来分析客户对电动汽车的采用情况。调查结果显示,消费者倾向于购买现代汽车,转而购买电动汽车。由于政府给予的贷款和税收补贴的好处,消费者转向电动汽车。由于行驶里程少,顾客们不愿换用电动汽车。因此,无法实现政府的2020年电力使命计划。
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引用次数: 2
Minireview: Membrane forward osmosis as alternative method in water treatment 膜正向渗透是水处理的一种替代方法
Pub Date : 2021-09-28 DOI: 10.1063/5.0059482
Saiful, Rahmi, Marlina
Water scarcity and limited water access for the community have encouraged the development of various technologies to facilitate access to various water sources in nature. Sea and brackish water desalination are the fastest and comfortable to meet growing water needs. The forward osmosis membranes is an alternative method for removing salt and impurity compounds both in brackish water and seawater to replace the reverse osmosis process in desalination of seawater and brackish water which are cheaper and environmentally friendly. A number of successes have been achieved in preparing FO membranes. Membranes can be made from either natural polymers or synthetic polymers. FO membrane performance improvement is still a challenge that researchers must continue to study and the challenges in implementing FO membranes on a large scale still face problems in the field that need to be overcome. In this paper discuss advance in FO membrane for seawater and brackish water desalination.
水的短缺和社区获得水的机会有限,鼓励了各种技术的发展,以便利人们获得自然界的各种水源。海水和微咸水的脱盐是最快和舒适的,以满足日益增长的用水需求。正向渗透膜是一种可替代海水和微咸水脱盐和杂质化合物的方法,可替代海水和微咸水脱盐的反渗透工艺,其成本较低且对环境友好。在制备氧化石墨烯膜方面已经取得了许多成功。膜可以由天然聚合物或合成聚合物制成。提高FO膜的性能仍然是研究人员必须继续研究的难题,大规模实施FO膜所面临的挑战仍然是该领域需要克服的问题。本文介绍了FO膜用于海水和微咸水淡化的研究进展。
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引用次数: 1
Alkyl glycol chitosan derivatives for encapsulation and controlled release of rotenone 鱼藤酮包封与控释的烷基乙二醇壳聚糖衍生物
Pub Date : 2021-09-28 DOI: 10.1063/5.0059890
A. Kamari, S. N. M. Yusoff, S. T. S. Wong, I. W. Sutapa
Rotenone is a hydrophobic organic compound with the excellent insecticidal property. However, its hydrophobicity and the short period of efficacy due to rapid degradation in the presence of UV light and air have limited its application as an insecticide. This study studied the effects of hydrophobic alkyl groups on encapsulation and controlled release of rotenone by amphiphilic chitosan derivatives namely, octyl glycol chitosan (OGC) and lauryl glycol chitosan (LGC) were assessed. The physical and chemical properties of OGC and LGC were characterized using Fourier Transform Infrared (FTIR) Spectrometer, CHNO Elemental Analyzer, UV-Visible Spectrophotometer, Fluorescence Spectrofluorometer, and Differential Scanning Calorimetry (DSC). The efficiency of OGC and LGC to encapsulate for rotenone in its micelles was determined by using a High-Performance Liquid Chromatography (HPLC). FTIR and CHNO elemental analyses confirmed the amphiphilic chitosan derivatives were successfully synthesized using the reverse micelles method. The finding from the solubility study shows that the addition of the glycol group to the chitosan backbone has enhanced chitosan’s solubility properties in neutral and basic media. OGC and LGC exhibited good affinity towards rotenone with an encapsulation efficiency of more than 90%. The in vitro release study showed that the OGC and LGC could control the release of rotenone from its micelles. This study demonstrates that OGC and LGC showed beneficial properties to be further developed as a potential carrier in the pesticide formulation.
鱼藤酮是一种疏水有机化合物,具有优良的杀虫性能。然而,它的疏水性和在紫外线和空气存在下迅速降解的短效期限制了它作为杀虫剂的应用。研究疏水烷基对两亲性壳聚糖衍生物辛乙二醇壳聚糖(OGC)和十二烷基壳聚糖(LGC)对鱼烯酮包封和控释的影响。采用傅里叶变换红外光谱仪(FTIR)、CHNO元素分析仪、紫外可见分光光度计、荧光分光光度计和差示扫描量热仪(DSC)对OGC和LGC的理化性质进行了表征。采用高效液相色谱法测定了OGC和LGC对鱼藤酮胶束的包封效率。FTIR和CHNO元素分析证实,采用反胶束法成功合成了两亲性壳聚糖衍生物。溶解度研究结果表明,在壳聚糖骨架上加入乙二醇基团增强了壳聚糖在中性和碱性介质中的溶解度。OGC和LGC对鱼藤酮具有良好的亲和性,包封率均在90%以上。体外释放研究表明,OGC和LGC可以控制鱼藤酮从胶束中的释放。本研究表明,OGC和LGC作为农药制剂的潜在载体具有良好的性能,值得进一步开发。
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引用次数: 1
Life cycle analysis of hydrogen 氢的生命周期分析
Pub Date : 2021-09-28 DOI: 10.1063/5.0066772
J. Ashwath, S. Kanishka, B. Jannan, A. Janardhan, A. Shailesh, S. Rathore, S. Vijayalakshmi, J. Ranjitha
The paper mainly focusses on the Life cycle assessment of Hydrogen produced by electrolysis process, the paper includes the properties of Hydrogen and its major production methods and electrolysis was considered to be best in terms of carbon dioxide equivalents. GHG's and other emissions are also accounted for each process later Hydrogen produced by Water splitting method and high temperature electrolysis was found to be better than other conventional methods. Also, the life cycle assessment focuses the environmental aspects of the production processes. The feasibility of Hydrogen fuel is also analyzed. The transportation of the produced fuel and the storage of Hydrogen is also discussed in this paper. We will be also discussing the drawbacks of using pure hydrogen in regular I.C engines. As a solution we compared the properties of Hydrogen in conventional I.C and S.I engines and it was found to have no better properties except lower emissions. Finally, we discussed about the safety norms of Hydrogen and its usage
本文主要对电解制氢的生命周期进行了评价,包括氢的性质及其主要生产方法,并认为电解在二氧化碳当量方面是最好的。对每道工序的温室气体和其他排放物也进行了计算,发现水裂解法和高温电解制氢优于其他传统方法。此外,生命周期评估侧重于生产过程的环境方面。并对氢燃料的可行性进行了分析。本文还讨论了生产燃料的运输和氢气的储存。我们还将讨论在常规内燃机中使用纯氢的缺点。作为一种解决方案,我们比较了氢在传统I.C和S.I发动机中的性能,发现除了更低的排放外,它没有更好的性能。最后,讨论了氢的安全规范及其使用
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引用次数: 0
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INTERNATIONAL CONFERENCE ON ENERGY AND ENVIRONMENT (ICEE 2021)
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