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Research progress in OX40/OX40L in allergic diseases. OX40/OX40L 在过敏性疾病中的研究进展。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-15 DOI: 10.1002/alr.23469
Rongrong Song, Huanlei Zhang, Zhuoping Liang

OX40/OX40L are costimulatory molecules in the tumor necrosis factor superfamily. Numerous studies have shown that OX40/OX40L are involved in immune regulation, especially in the proliferation and differentiation of T cells and the generation of memory T cells, which play important roles in allergic diseases. In recent years, the use of OX40/OX40L as therapeutic targets for treating T-cell-mediated diseases has attracted the interest of scholars. This paper reviews the role of OX40/OX40L in allergic diseases and the progress in clinical treatments targeting this signaling pathway.

OX40/OX40L 是肿瘤坏死因子超家族中的激动分子。大量研究表明,OX40/OX40L 参与免疫调节,特别是参与 T 细胞的增殖和分化以及记忆 T 细胞的生成,在过敏性疾病中发挥重要作用。近年来,将 OX40/OX40L 作为治疗 T 细胞介导疾病的靶点引起了学者们的兴趣。本文回顾了OX40/OX40L在过敏性疾病中的作用以及针对这一信号通路的临床治疗进展。
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引用次数: 0
Efficacy and safety of omalizumab combined with allergen immunotherapy in children with moderate to severe allergic asthma. 奥马珠单抗联合过敏原免疫疗法对中重度过敏性哮喘患儿的疗效和安全性。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-15 DOI: 10.1002/alr.23470
Wenxin Shen, Qianlan Zhou, Qinzhen Zhang, Lina Han, Li Chen, Xiaowen Li, Bing Dai, Si Liu, Lishen Shan

Key points: Omalizumab enables children who are intolerant to AIT to initiate AIT successfully. Combination therapy better improves asthma and rhinitis symptoms, FeNO, and lung function compared to single SCIT or omalizumab treatment. Combination therapy reduces the incidence of adverse reactions during the initial phase of SCIT and enhances its safety.

要点奥马珠单抗能让对 AIT 不耐受的儿童成功启动 AIT。与单一SCIT或奥马珠单抗治疗相比,联合疗法能更好地改善哮喘和鼻炎症状、FeNO和肺功能。联合疗法降低了SCIT初始阶段不良反应的发生率,提高了安全性。
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引用次数: 0
A preliminary review of the utility of artificial intelligence to detect eosinophilic chronic rhinosinusitis. 人工智能在检测嗜酸性粒细胞慢性鼻炎方面的实用性初步评述。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-10 DOI: 10.1002/alr.23463
Jayanth Rajan, Ross Rosen, Daniel Karasik, John Richter, Claudia Cabrera, Brian D'Anza, Kenneth Rodriguez, Sanjeet V Rangarajan

Key points: While typically diagnosed with biopsy, ECRS may be predicted preoperatively with the use of AI. Various AI models have been used, with pooled sensitivity of 0.857 and specificity of 0.850. We found no statistically significant difference between the accuracy of various AI models.

要点:虽然 ECRS 通常是通过活组织检查诊断出来的,但也可以通过 AI 进行术前预测。我们使用了各种人工智能模型,汇总灵敏度为 0.857,特异度为 0.850。我们发现各种人工智能模型的准确性在统计学上没有明显差异。
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引用次数: 0
Orthonasal and retronasal olfactory function in patients with chronic rhinosinusitis without nasal polyps undergoing endoscopic sinonasal surgery. 接受鼻窦内窥镜手术的无鼻息肉慢性鼻窦炎患者的正鼻腔和反鼻腔嗅觉功能。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-10 DOI: 10.1002/alr.23467
Paolo Boscolo-Rizzo, Claire Hopkins, Thomas Hummel, Anna Menini, Francesco Uderzo, Giulia Provenza, Giacomo Spinato, Enzo Emanuelli, Giancarlo Tirelli

Background: Olfactory dysfunction (OD) is a key symptom of chronic rhinosinusitis (CRS). Although extensively studied in CRS with nasal polyps (CRSwNP), OD in CRS without nasal polyps (CRSsNP) remains under-researched. This study aims to assess the prevalence of OD and its evolution in surgically naïve patients with CRSsNP undergoing endoscopic sinus surgery (ESS).

Methods: This prospective study included 97 participants with CRSsNP (mean age, 46.5 years; 70.1% men) and 97 healthy controls (mean age, 46.5 years; 70.1% men). Participants underwent psychophysical evaluations of orthonasal (using the Sniffin' Sticks test) and retronasal olfaction (using powdered aromas) at enrolment and 6 months post-ESS.

Results: Out of 97 patients, 81 (83.5%) completed all assessments. At enrolment, 23 (28.4%) CRSsNP patients had OD based on composite threshold, discrimination, identification scores, compared with 7 (8.6%) controls (absolute % difference, 19.8% [95% CI, 8.2-31.4]). Retronasal olfactory function was also significantly worse in CRSsNP patients. Six months post-ESS, 30 patients (37.0%) experienced a clinically significant improvement in olfactory, whereas nonsignificant changes were observed in retronasal olfactory score, and 3.7% of patients experienced a deterioration of the olfactory function.

Conclusions: In conclusion, although 37% of patients experienced a clinically significant improvement in their sense of smell following ESS, the overall prevalence of OD in this surgically naive population appears relatively low, especially when compared to that observed in patients with CRSwNP. Therefore, ESS may offer some benefits for enhancing orthonasal olfactory function, but the extent of these improvements appears to be limited.

背景:嗅觉功能障碍(OD)是慢性鼻炎(CRS)的一个主要症状。虽然对有鼻息肉的慢性鼻炎(CRSwNP)进行了广泛研究,但对无鼻息肉的慢性鼻炎(CRSsNP)的嗅觉障碍研究仍然不足。本研究旨在评估接受内窥镜鼻窦手术(ESS)的无鼻息肉 CRS 患者的 OD 患病率及其演变情况:这项前瞻性研究包括 97 名 CRSsNP 患者(平均年龄 46.5 岁;70.1% 为男性)和 97 名健康对照者(平均年龄 46.5 岁;70.1% 为男性)。参与者在入学时和接受心理治疗后 6 个月接受了正鼻嗅觉(使用嗅棒测试)和反鼻嗅觉(使用香粉)的心理物理评估:97 名患者中,81 人(83.5%)完成了所有评估。入学时,根据阈值、辨别力和识别力的综合评分,23 名(28.4%)CRSsNP 患者有 OD,而对照组为 7 名(8.6%)(绝对百分比差异为 19.8% [95% CI, 8.2-31.4])。CRSsNP 患者的视网膜嗅觉功能也明显较差。ESS后6个月,30名患者(37.0%)的嗅觉有了临床意义上的显著改善,而视网膜嗅觉评分则无明显变化,3.7%的患者嗅觉功能恶化:总之,尽管 37% 的患者在接受 ESS 治疗后嗅觉有了明显改善,但在这一未接受手术的人群中,OD 的总体发病率似乎相对较低,尤其是与在 CRSwNP 患者中观察到的情况相比。因此,ESS 可为增强正鼻嗅觉功能带来一些益处,但其改善程度似乎有限。
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引用次数: 0
Effects of functional endoscopic sinus surgery on asthma control in patients with comorbid chronic rhinosinusitis and asthma: A national database study. 功能性内窥镜鼻窦手术对合并慢性鼻炎和哮喘患者哮喘控制的影响:一项国家数据库研究。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-08 DOI: 10.1002/alr.23462
Mbuyi Madeleine Kabongo, Joshua M Levy, Lauren T Roland

Key points: In patients with chronic rhinosinusitis and comorbid asthma, patients with surgical intervention required less asthma rescue medication, as compared to those who did not undergo surgery. Following sinus surgery, patients with chronic rhinosinusitis and asthma required more asthma medication, as compared to the time period prior to surgery.

要点与未接受手术治疗的患者相比,接受手术治疗的慢性鼻炎合并哮喘患者所需的哮喘抢救药物更少。鼻窦手术后,与手术前相比,慢性鼻炎和哮喘患者需要更多的哮喘药物。
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引用次数: 0
Stepwise Empty Nose Syndrome Evaluation (SENSE) test-A modified cotton test for reduced bias in office diagnosis of empty nose syndrome. 渐进式空鼻综合征评估(SENSE)测试--改良棉花测试,以减少办公室诊断空鼻综合征的偏差。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-07 DOI: 10.1002/alr.23442
Lirit Levi, Angela Yang, Esmond F Tsai, Yifei Ma, Nour Ibrahim, Sachi S Dholakia, Vidya K Rao, Axel Renteria, Xueying Cao, Michael T Chang, Jayakar V Nayak

Introduction: Diagnosis of empty nose syndrome (ENS) relies on the ENS six-item questionnaire (ENS6Q) with a score of ≥11, followed by a "positive" cotton test yielding seven-point reduction from baseline ENS6Q score via cotton placement to the inferior meatus (IM). Given the intricacies of diagnosing ENS and the propensity for false positives with the standard cotton test, we modified the classic single-step cotton test into a four-part Stepwise Empty Nose Syndrome Evaluation (SENSE) cotton test to reduce bias and evaluate the placebo effect.

Methods: Individuals diagnosed with ENS underwent the SENSE test, a single-blinded, four-step, office-based cotton test, without topical anesthesia or decongestants. Conditions included: (1) placebo/no cotton placed; (2) complete cotton-blockade of nasal vestibule; (3) cotton placed medially against the nasal septum; and (4) cotton placed laterally in the IM (site of inferior turbinate tissue loss). With each condition, patients completed an ENS6Q.

Results: Forty-eight ENS patients were included. Twenty-nine percent demonstrated a placebo effect (p < 0.001), 40.4% had a positive response to complete cotton-blockade (p < 0.001), 64.4% to septum-placed cotton, and 79.1% to IM-placed cotton (p < 0.001), corresponding to a mean ENS6Q reduction of 11.9 points (p < 0.001). Notably, the mean difference in ENS6Q scores between septum and IM placement was 1.7 (p < 0.001).

Conclusions: The SENSE test offers further insight into subtleties of nasal breathing experienced by ENS patients. The placebo effect can be prominent and important to consider with individual patients. While most ENS patients prefer any intranasal cotton placement over baseline, blinded testing reveals these patients can accurately discriminate minimal changes in nasal aerodynamics.

简介空鼻综合征(ENS)的诊断依赖于ENS六项问卷(ENS6Q),得分≥11分,然后通过将棉花置于下肉眼(IM)进行 "阳性 "棉花测试,使ENS6Q得分从基线降低7分。考虑到 ENS 诊断的复杂性和标准棉花试验的假阳性倾向,我们将经典的单步棉花试验修改为由四个部分组成的逐步空鼻综合征评估(SENSE)棉花试验,以减少偏差并评估安慰剂效应:方法: 诊断出患有空鼻症的患者接受 SENSE 测试,这是一种单盲、四步、办公室棉花测试,无需局部麻醉或减充血剂。测试条件包括(1) 安慰剂/不放棉花;(2) 完全用棉花堵塞鼻前庭;(3) 在鼻中隔内侧放棉花;(4) 在 IM(下鼻甲组织缺失部位)外侧放棉花。每种情况下,患者都要填写 ENS6Q:结果:共纳入 48 名 ENS 患者。结果:纳入了 48 名 ENS 患者,其中 29% 的患者表现出安慰剂效应(P 结论):SENSE 测试可进一步了解 ENS 患者鼻呼吸的微妙之处。安慰剂效应可能非常明显,对个别患者来说需要加以考虑。与基线相比,大多数耳鼻咽喉科病人更喜欢鼻内放置棉花,但盲测显示这些病人能准确分辨鼻腔空气动力学的微小变化。
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引用次数: 0
Roles of noncoding RNA in allergic rhinitis 非编码 RNA 在过敏性鼻炎中的作用。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-05 DOI: 10.1002/alr.23461
Xiangkun Zhao BS, Yuteng Yang BS, Yaqi Wang BS, Xi Chen BS, Yisong Yao BS, Ting Yuan BS, Jiaxuan Li BS, Yumei Li PhD, Xicheng Song PhD

Background

Allergic rhinitis (AR) is one of the most common respiratory noninfectious diseases and chronic inflammatory diseases, the incidence of which has been increasing in recent years. The main pathological characteristics of AR are repeated inflammation, airway hyperreactivity, mucus hypersecretion, and reversible airway obstruction due to inflammatory cell response. AR occurrence is associated with various factors, including those of genetic and environmental origins. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.

Methods

Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Several recent studies have indicated the relationship of ncRNAs with the development of respiratory allergic diseases. NcRNAs, including miRNAs, lncRNAs, and circRNAs, are important gene expression regulatory factors. We review the expression and function of ncRNAs in AR, their role as disease biomarkers, and their prospective applicability in future research and clinically. We also discuss interactions between ncRNAs and their influence on AR comprehensively, these interactions are essential for determining the underlying pathological mechanisms further and discovering new drug therapeutic targets.

Results

NcRNAs can be used as biomarkers for early AR diagnosis, disease surveillance and prognosis assessment. Various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. They are also therapeutic targets and biomarkers in other allergic diseases.

Conclusion

This article demonstrates ncRNAs have a wide range of applications in AR treatment. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore. With further research and technological development, ncRNAs may provide additional innovative, effective solutions for AR treatment.

背景:过敏性鼻炎(AR)是最常见的呼吸道非感染性疾病和慢性炎症性疾病之一,近年来发病率呈上升趋势。过敏性鼻炎的主要病理特征是反复发炎、气道高反应性、粘液分泌过多以及炎症细胞反应导致的可逆性气道阻塞。AR 的发生与多种因素有关,包括遗传和环境因素。非编码 RNA(ncRNA)是一组不能转化为多肽的 RNA 分子。ncRNA 主要分为三类,包括微小 RNA(miRNA)、长 ncRNA(lncRNA)和环状 RNA(circRNA)。NcRNAs 在控制基因表达方面起着至关重要的作用,并导致多种人类疾病的发生:根据 Pubmed 的文献综述和作者的个人知识选择文章。其中包括规模最大、质量最高的研究。搜索选择没有标准化。最近的几项研究表明,ncRNA 与呼吸道过敏性疾病的发生有关。NcRNA(包括 miRNA、lncRNA 和 circRNA)是重要的基因表达调控因子。我们综述了 ncRNA 在 AR 中的表达和功能、它们作为疾病生物标志物的作用以及在未来研究和临床中的应用前景。我们还全面讨论了 ncRNA 之间的相互作用及其对 AR 的影响,这些相互作用对于进一步确定潜在的病理机制和发现新的药物治疗靶点至关重要:NcRNA可作为生物标志物用于早期AR诊断、疾病监测和预后评估。各类 ncRNA 发挥着不同但相互关联的作用,并在错综复杂的基因调控网络中发挥着积极作用。它们也是其他过敏性疾病的治疗靶点和生物标志物:本文展示了 ncRNA 在 AR 治疗中的广泛应用。该数据库涵盖三个关键领域:miRNAs、lncRNAs 和 circRNAs。此外,还将探讨未来研究的潜在途径,以促进 ncRNAs 作为治疗靶点和生物标志物的实际应用。随着进一步的研究和技术发展,ncRNA 可能会为 AR 治疗提供更多创新、有效的解决方案。
{"title":"Roles of noncoding RNA in allergic rhinitis","authors":"Xiangkun Zhao BS,&nbsp;Yuteng Yang BS,&nbsp;Yaqi Wang BS,&nbsp;Xi Chen BS,&nbsp;Yisong Yao BS,&nbsp;Ting Yuan BS,&nbsp;Jiaxuan Li BS,&nbsp;Yumei Li PhD,&nbsp;Xicheng Song PhD","doi":"10.1002/alr.23461","DOIUrl":"10.1002/alr.23461","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic rhinitis (AR) is one of the most common respiratory noninfectious diseases and chronic inflammatory diseases, the incidence of which has been increasing in recent years. The main pathological characteristics of AR are repeated inflammation, airway hyperreactivity, mucus hypersecretion, and reversible airway obstruction due to inflammatory cell response. AR occurrence is associated with various factors, including those of genetic and environmental origins. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Articles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Several recent studies have indicated the relationship of ncRNAs with the development of respiratory allergic diseases. NcRNAs, including miRNAs, lncRNAs, and circRNAs, are important gene expression regulatory factors. We review the expression and function of ncRNAs in AR, their role as disease biomarkers, and their prospective applicability in future research and clinically. We also discuss interactions between ncRNAs and their influence on AR comprehensively, these interactions are essential for determining the underlying pathological mechanisms further and discovering new drug therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NcRNAs can be used as biomarkers for early AR diagnosis, disease surveillance and prognosis assessment. Various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. They are also therapeutic targets and biomarkers in other allergic diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This article demonstrates ncRNAs have a wide range of applications in AR treatment. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore. With further research and technological development, ncRNAs may provide additional innovative, effective solutions for AR treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 11","pages":"1757-1775"},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S100A9 induces tissue remodeling of human nasal epithelium in chronic rhinosinusitis with nasal polyp. S100A9 可诱导慢性鼻炎伴鼻息肉患者鼻腔上皮组织重塑。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-05 DOI: 10.1002/alr.23460
Sang Hyeon Ahn, Jun Taek Oh, Dae Hyun Kim, Eun Jung Lee, Min-Seok Rha, Hyung-Ju Cho, Chang-Hoon Kim

Background: Chronic inflammation triggers tissue remodeling in human nasal epithelial (HNE) cells. S100A9, a protein secreted by inflammatory cells, exhibits potent proinflammatory activity. However, its effect on HNE cell remodeling, such as squamous metaplasia, remains unclear. Therefore, this study aimed to determine the effects and underlying pathways of S100A9 on HNE cell remodeling and investigate its clinical implications in chronic rhinosinusitis (CRS).

Methods: Cultured HNE cells were treated with S100A9. Bulk RNA sequencing was performed to analyze gene ontology (GO). Ingenuity pathway analysis (IPA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were also analyzed. Additionally, immunohistochemistry and multiplex immunofluorescence were performed on tissue samples obtained from 60 patients, whose clinical informations were also reviewed.

Results: GO enrichment analysis indicated that S100A9 induced tissue remodeling in HNE cells toward squamous metaplasia. IPA and KEGG commonly showed that S100A9 affected HNE cells associated with the IL-17 signaling pathway, including target molecules such as matrix metalloproteinase 1 (MMP1) and small proline-rich protein 2A (SPRR2A). Squamous metaplasia with a marked expression of S100A9 was observed in 50% of CRS with nasal polyps (CRSwNPs). In addition, in multiplex immunofluorescence, the S100A9 in sub-epithelium was co-expressed with myeloperoxidase, a neutrophil marker, and MMP1 and SPRR2A were strongly expressed in epithelial remodeling. Clinically, the expression of S100A9 correlated with sino-nasal outcome test-22 (r = 0.294, p = 0.022) and Lund-Mackay scores (r = 0.348, p = 0.006).

Conclusion: S100A9 induces tissue remodeling in HNE cells. Its increased expression in CRSwNP, particularly squamous epithelium, correlates with disease severity. This suggests the clinical potential of S100A9 as a biomarker for CRS severity.

背景:慢性炎症会引发人类鼻上皮细胞(HNE)的组织重塑。S100A9是炎症细胞分泌的一种蛋白质,具有强大的促炎活性。然而,它对 HNE 细胞重塑(如鳞状化)的影响仍不清楚。因此,本研究旨在确定 S100A9 对 HNE 细胞重塑的影响及其潜在途径,并探讨其对慢性鼻炎(CRS)的临床意义:方法:用S100A9处理培养的HNE细胞。方法:用 S100A9 处理培养的 HNE 细胞,进行大量 RNA 测序,分析基因本体(GO)。还分析了基因通路分析(IPA)和京都基因与基因组百科全书(KEGG)。此外,还对 60 例患者的组织样本进行了免疫组化和多重免疫荧光分析,并对其临床信息进行了审查:结果:GO富集分析表明,S100A9诱导HNE细胞向鳞状化生方向进行组织重塑。IPA和KEGG共同表明,S100A9对HNE细胞的影响与IL-17信号通路有关,包括基质金属蛋白酶1(MMP1)和富含脯氨酸的小蛋白2A(SPRR2A)等靶分子。在 50%的鼻息肉 CRS(CRSwNPs)中观察到鳞状化生,S100A9 明显表达。此外,在多重免疫荧光中,上皮下的 S100A9 与中性粒细胞标记物髓过氧化物酶共表达,MMP1 和 SPRR2A 在上皮重塑中强表达。在临床上,S100A9的表达与中鼻结局测试-22(r = 0.294,p = 0.022)和Lund-Mackay评分(r = 0.348,p = 0.006)相关:结论:S100A9 可诱导 HNE 细胞的组织重塑。结论:S100A9 可诱导 HNE 细胞组织重塑,其在 CRSwNP(尤其是鳞状上皮)中的表达增加与疾病严重程度相关。这表明 S100A9 具有作为 CRS 严重程度生物标志物的临床潜力。
{"title":"S100A9 induces tissue remodeling of human nasal epithelium in chronic rhinosinusitis with nasal polyp.","authors":"Sang Hyeon Ahn, Jun Taek Oh, Dae Hyun Kim, Eun Jung Lee, Min-Seok Rha, Hyung-Ju Cho, Chang-Hoon Kim","doi":"10.1002/alr.23460","DOIUrl":"https://doi.org/10.1002/alr.23460","url":null,"abstract":"<p><strong>Background: </strong>Chronic inflammation triggers tissue remodeling in human nasal epithelial (HNE) cells. S100A9, a protein secreted by inflammatory cells, exhibits potent proinflammatory activity. However, its effect on HNE cell remodeling, such as squamous metaplasia, remains unclear. Therefore, this study aimed to determine the effects and underlying pathways of S100A9 on HNE cell remodeling and investigate its clinical implications in chronic rhinosinusitis (CRS).</p><p><strong>Methods: </strong>Cultured HNE cells were treated with S100A9. Bulk RNA sequencing was performed to analyze gene ontology (GO). Ingenuity pathway analysis (IPA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were also analyzed. Additionally, immunohistochemistry and multiplex immunofluorescence were performed on tissue samples obtained from 60 patients, whose clinical informations were also reviewed.</p><p><strong>Results: </strong>GO enrichment analysis indicated that S100A9 induced tissue remodeling in HNE cells toward squamous metaplasia. IPA and KEGG commonly showed that S100A9 affected HNE cells associated with the IL-17 signaling pathway, including target molecules such as matrix metalloproteinase 1 (MMP1) and small proline-rich protein 2A (SPRR2A). Squamous metaplasia with a marked expression of S100A9 was observed in 50% of CRS with nasal polyps (CRSwNPs). In addition, in multiplex immunofluorescence, the S100A9 in sub-epithelium was co-expressed with myeloperoxidase, a neutrophil marker, and MMP1 and SPRR2A were strongly expressed in epithelial remodeling. Clinically, the expression of S100A9 correlated with sino-nasal outcome test-22 (r = 0.294, p = 0.022) and Lund-Mackay scores (r = 0.348, p = 0.006).</p><p><strong>Conclusion: </strong>S100A9 induces tissue remodeling in HNE cells. Its increased expression in CRSwNP, particularly squamous epithelium, correlates with disease severity. This suggests the clinical potential of S100A9 as a biomarker for CRS severity.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites” 对 "滤泡调节性 T 细胞数量的增加与屋尘螨舌下免疫疗法的临床疗效相关 "的更正。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-10-05 DOI: 10.1002/alr.23465
<p>Murao T, Kouzaki H, Arai H, et al. Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites. <i>Int Forum Allergy Rhinol</i>. 2024;14:57−67. doi:10.1002/alr.23221</p><p>In the article cited above, the authors have determined that the legends for Figures 3 and 5 had incorrect parts, some methods were omitted in the online supplementary materials, and one reference was cited incorrectly.</p><p>The corrected figure legends appear below; the online supplementary materials have been revised and published online.</p><p>DISCUSSION</p><p>Page 64, right column, second paragraph, line 6: Yao et al.<sup>18</sup> reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.<sup>21</sup></p><p>Should be changed to: Yao et al.<sup>21</sup> reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.<sup>21</sup></p><p>Page 64, right column, second paragraph, line 14: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.<sup>18</sup></p><p>Should be changed to: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.<sup>21</sup></p><p><b>Figure legend 3</b></p><p>Serum concentrations of house dust mite (HDM)–specific IgA, IgE, and IgG4 antibodies. (A) Prior to treatment, the serum concentrations of HDM-specific IgE were significantly higher in patients with allergic rhinitis (AR) than in healthy controls (HCs; HC: 0.08 ± 0.01 optimal density [OD] value, AR: 0.99 ± 0.08 OD value), while no significant difference was detected in serum concentrations of HDM-specific IgA (HC: 0.68 ± 0.05 OD value, AR: 0.69 ± 0.04 OD value) and HDM-specific IgG4 (HC: 1.17 ± 0.14 OD value, AR: 1.31 ± 0.15 OD value). (B) Changes in serum concentrations of HDM-specific IgA, IgE, and IgG4 in patients with AR before and after sublingual immunotherapy (SLIT). Serum concentrations of HDM-specific IgA and IgG4 were significantly increased after 1 year of SLIT; those of HDM-specific IgE did not change significantly after SLIT. Comparisons of data from two independent groups were performed using a two-tailed Mann–Whitney <i>U-</i>test. Paired data were analyzed by the Wilcoxon signed rank test. **<i>p </i>< 0.01, *<i>p </i>< 0.05; ns, not significant. Where indicated, values are provided as mean ± standard error of the mean.</p><p><b>Figure legend 5</b></p><p>(A) Total nasal ocular symptom score (TNOSS) and visual analog scale (VAS) scores in patients with allergic rhinitis (AR) before and after sublingual immunotherapy (SLIT). Both symptom scores were significantly improved after 1 year of SLIT. (B) Correlation between the improvements in TNOSS and VAS scores, and the prevalence of cluster of differentiation 4 (CD4)+ T-cell subse
Murao T, Kouzaki H, Arai H, et al. 滤泡调节性 T 细胞的增加与屋尘螨舌下免疫疗法的临床疗效相关。Int Forum Allergy Rhinol.doi:10.1002/alr.23221在上述文章中,作者发现图3和图5的图例部分有误,在线补充材料中遗漏了一些方法,并且错误引用了一篇参考文献:Yao等人18报道Tfr细胞调节抗原特异性IgE的产生,并且Tfr细胞的流行和功能下降在SCIT后恢复:21第 64 页,右栏,第二段,第 14 行:这些结果与先前的一项研究一致,表明 Tfr 细胞在 SCIT 中起关键作用:这些结果与之前的一项研究结果一致,表明 Tfr 细胞在 SCIT 中起着关键作用。(A)在治疗前,过敏性鼻炎(AR)患者血清中 HDM 特异性 IgE 的浓度明显高于健康对照组(HCs;HC:0.08 ± 0.01 最适密度 [OD] 值,AR:0.99 ± 0.08 OD 值)。08 OD 值),而血清中 HDM 特异性 IgA(HC:0.68 ± 0.05 OD 值,AR:0.69 ± 0.04 OD 值)和 HDM 特异性 IgG4(HC:1.17 ± 0.14 OD 值,AR:1.31 ± 0.15 OD 值)的浓度则无明显差异。(B)舌下免疫疗法(SLIT)前后 AR 患者血清中 HDM 特异性 IgA、IgE 和 IgG4 浓度的变化。接受舌下免疫疗法 1 年后,血清中 HDM 特异性 IgA 和 IgG4 的浓度明显升高;接受舌下免疫疗法后,血清中 HDM 特异性 IgE 的浓度无明显变化。两组独立数据的比较采用双尾曼-惠特尼 U 检验。配对数据采用 Wilcoxon 符号秩检验进行分析。**p < 0.01,*p < 0.05;ns,无显著性意义。图例 5(A) 舌下免疫疗法(SLIT)前后过敏性鼻炎(AR)患者的鼻眼症状总分(TNOSS)和视觉模拟量表(VAS)评分。使用舌下免疫疗法一年后,这两项症状评分均有明显改善。(B) 在舌下含服免疫疗法(SLIT)前后评估的过敏性鼻炎(AR)患者 TNOSS 和 VAS 评分的改善与分化群 4 (CD4)+ T 细胞亚群(滤泡调节性 T [Tfr]、2 型辅助性 T [Th2] 和 1 型调节性 T [Tr1] 细胞)的发病率;以及 HDM 诱导的外周血单核细胞(PBMCs)白细胞介素(IL)-5 和 IL-10 的产生之间的相关性。两种症状评分的改善与 Tfr 细胞和 Tfh 细胞比例(后 Tfr 细胞/前 Tfr 细胞)的增加呈正相关。在症状评分、Tr1 和 Th2 细胞流行率的变化以及 HDM 诱导的 IL-5 和 IL-10 的产生之间均未发现相关性。相关性通过斯皮尔曼秩相关分析进行评估。*p < 0.05.作者对这些错误表示遗憾。
{"title":"Correction to “Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites”","authors":"","doi":"10.1002/alr.23465","DOIUrl":"10.1002/alr.23465","url":null,"abstract":"&lt;p&gt;Murao T, Kouzaki H, Arai H, et al. Increase in the prevalence of follicular regulatory T cells correlates with clinical efficacy of sublingual immunotherapy with house dust mites. &lt;i&gt;Int Forum Allergy Rhinol&lt;/i&gt;. 2024;14:57−67. doi:10.1002/alr.23221&lt;/p&gt;&lt;p&gt;In the article cited above, the authors have determined that the legends for Figures 3 and 5 had incorrect parts, some methods were omitted in the online supplementary materials, and one reference was cited incorrectly.&lt;/p&gt;&lt;p&gt;The corrected figure legends appear below; the online supplementary materials have been revised and published online.&lt;/p&gt;&lt;p&gt;DISCUSSION&lt;/p&gt;&lt;p&gt;Page 64, right column, second paragraph, line 6: Yao et al.&lt;sup&gt;18&lt;/sup&gt; reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.&lt;sup&gt;21&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;Should be changed to: Yao et al.&lt;sup&gt;21&lt;/sup&gt; reported that Tfr cells regulate antigen-specific IgE production and that the prevalence and decreased function of Tfr cells recovered following SCIT.&lt;sup&gt;21&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;Page 64, right column, second paragraph, line 14: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.&lt;sup&gt;18&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;Should be changed to: These results are consistent with those of a previous study showing a key role for Tfr cells in SCIT.&lt;sup&gt;21&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Figure legend 3&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Serum concentrations of house dust mite (HDM)–specific IgA, IgE, and IgG4 antibodies. (A) Prior to treatment, the serum concentrations of HDM-specific IgE were significantly higher in patients with allergic rhinitis (AR) than in healthy controls (HCs; HC: 0.08 ± 0.01 optimal density [OD] value, AR: 0.99 ± 0.08 OD value), while no significant difference was detected in serum concentrations of HDM-specific IgA (HC: 0.68 ± 0.05 OD value, AR: 0.69 ± 0.04 OD value) and HDM-specific IgG4 (HC: 1.17 ± 0.14 OD value, AR: 1.31 ± 0.15 OD value). (B) Changes in serum concentrations of HDM-specific IgA, IgE, and IgG4 in patients with AR before and after sublingual immunotherapy (SLIT). Serum concentrations of HDM-specific IgA and IgG4 were significantly increased after 1 year of SLIT; those of HDM-specific IgE did not change significantly after SLIT. Comparisons of data from two independent groups were performed using a two-tailed Mann–Whitney &lt;i&gt;U-&lt;/i&gt;test. Paired data were analyzed by the Wilcoxon signed rank test. **&lt;i&gt;p &lt;/i&gt;&lt; 0.01, *&lt;i&gt;p &lt;/i&gt;&lt; 0.05; ns, not significant. Where indicated, values are provided as mean ± standard error of the mean.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Figure legend 5&lt;/b&gt;&lt;/p&gt;&lt;p&gt;(A) Total nasal ocular symptom score (TNOSS) and visual analog scale (VAS) scores in patients with allergic rhinitis (AR) before and after sublingual immunotherapy (SLIT). Both symptom scores were significantly improved after 1 year of SLIT. (B) Correlation between the improvements in TNOSS and VAS scores, and the prevalence of cluster of differentiation 4 (CD4)+ T-cell subse","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"14 11","pages":"1838-1839"},"PeriodicalIF":7.2,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.23465","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-derived organoid model of olfactory ensheathing cell tumor. 源于患者的嗅鞘细胞瘤类器官模型。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-09-27 DOI: 10.1002/alr.23464
John B Finlay, Ralph Abi Hachem, Patrick Codd, Bradley J Goldstein

Key points: We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.

要点:我们建立了人类嗅觉鞘细胞肿瘤的培养模型。培养的器官组织类似于正常的鞘状细胞。实验表明,该模型为研究这些神经胶质细胞在维持外周嗅觉系统中的作用提供了一种工具。
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引用次数: 0
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International Forum of Allergy & Rhinology
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