首页 > 最新文献

International Forum of Allergy & Rhinology最新文献

英文 中文
The impact of cadaveric donor transplant on the development of chronic rhinosinusitis and recalcitrant disease. 尸体供体移植对慢性鼻炎和顽固性疾病发展的影响。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-24 DOI: 10.1002/alr.23429
Estephania Candelo, Anyull D Bohorquez-Caballero, Karol Avila-Castano, Hani Wadei, Angela M Donaldson

Key points: The study found a higher incidence of chronic rhinosinusitis (CRS) and recalcitrant CRS in cadaveric organ transplant recipients compared to those receiving living donor transplants. Recipients of cadaveric transplants were 1.32 times more likely to develop CRS and 1.68 times more likely to develop medically recalcitrant CRS. Living kidney transplants significantly reduced the risk of developing CRS (OR = 0.12) and recalcitrant CRS (OR = 0.11), highlighting a potentially protective effect against these conditions. In contrast, cadaveric liver transplants were associated with an increased risk of CRS and medically recalcitrant CRS. Kaplan-Meier survival analysis indicated a significant difference in time to CRS onset between cadaveric and living donor transplants. Median time to CRS onset was longer for living donor recipients (21.1 months) compared to cadaveric recipients (15.6 months). This study underscores the need for transplant teams and otolaryngologist to consider donor type during transplant follow-up due to differing risks of CRS development.

要点研究发现,与接受活体器官移植的受者相比,尸体器官移植受者的慢性鼻炎(CRS)和顽固性CRS发病率更高。尸体器官移植受者患 CRS 的几率是活体器官移植受者的 1.32 倍,患药物难治性 CRS 的几率是活体器官移植受者的 1.68 倍。活体肾移植大大降低了罹患CRS(OR = 0.12)和顽固性CRS(OR = 0.11)的风险,凸显了对这些疾病的潜在保护作用。相比之下,尸体肝移植与CRS和医学上顽固的CRS风险增加有关。Kaplan-Meier生存分析表明,尸体移植和活体移植的CRS发病时间存在显著差异。活体器官移植受者发生 CRS 的中位时间(21.1 个月)长于尸体器官移植受者(15.6 个月)。这项研究强调,由于 CRS 发生的风险不同,移植团队和耳鼻喉科医生在移植随访过程中需要考虑供体类型。
{"title":"The impact of cadaveric donor transplant on the development of chronic rhinosinusitis and recalcitrant disease.","authors":"Estephania Candelo, Anyull D Bohorquez-Caballero, Karol Avila-Castano, Hani Wadei, Angela M Donaldson","doi":"10.1002/alr.23429","DOIUrl":"https://doi.org/10.1002/alr.23429","url":null,"abstract":"<p><strong>Key points: </strong>The study found a higher incidence of chronic rhinosinusitis (CRS) and recalcitrant CRS in cadaveric organ transplant recipients compared to those receiving living donor transplants. Recipients of cadaveric transplants were 1.32 times more likely to develop CRS and 1.68 times more likely to develop medically recalcitrant CRS. Living kidney transplants significantly reduced the risk of developing CRS (OR = 0.12) and recalcitrant CRS (OR = 0.11), highlighting a potentially protective effect against these conditions. In contrast, cadaveric liver transplants were associated with an increased risk of CRS and medically recalcitrant CRS. Kaplan-Meier survival analysis indicated a significant difference in time to CRS onset between cadaveric and living donor transplants. Median time to CRS onset was longer for living donor recipients (21.1 months) compared to cadaveric recipients (15.6 months). This study underscores the need for transplant teams and otolaryngologist to consider donor type during transplant follow-up due to differing risks of CRS development.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor regarding “Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma”: The utility of topical cidofovir 致编辑的信,内容涉及 "局部注射西多福韦治疗多灶性鼻窦外生乳头状瘤":局部西多福韦的效用。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-23 DOI: 10.1002/alr.23437
Briana R. Halle MD, Edward C. Kuan MD, Melissa Shive MD, MPH
{"title":"Letter to the editor regarding “Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma”: The utility of topical cidofovir","authors":"Briana R. Halle MD,&nbsp;Edward C. Kuan MD,&nbsp;Melissa Shive MD, MPH","doi":"10.1002/alr.23437","DOIUrl":"10.1002/alr.23437","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpretability of operative and pathological reports for radiotherapy planning of sinonasal carcinomas: An ancillary study of the GORTEC 2016-02 SANTAL trial. 鼻窦癌放疗计划中手术和病理报告的可读性:GORTEC 2016-02 SANTAL试验的辅助研究。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-20 DOI: 10.1002/alr.23433
Coline Labarre, Florent Carsuzaa, Maxime Fieux, Benjamin Verillaud, Antoine Moya Plana, Ludovic de Gabory, Vincent Patron, Francois-Régis Ferrand, Juliette Thariat

Key points: Interpretation of surgical mapping is essential for postoperative radiotherapy planning. Operative and pathological reports lack comprehensive information on margins quality and tissue block mapping. Standardizing reports is essential to reduce uncertainties, aiming for less morbid poRT.

要点:解读手术图谱对术后放疗计划至关重要。手术和病理报告缺乏关于边缘质量和组织块映射的全面信息。标准化报告对减少不确定性至关重要,其目的是降低放疗的发病率。
{"title":"Interpretability of operative and pathological reports for radiotherapy planning of sinonasal carcinomas: An ancillary study of the GORTEC 2016-02 SANTAL trial.","authors":"Coline Labarre, Florent Carsuzaa, Maxime Fieux, Benjamin Verillaud, Antoine Moya Plana, Ludovic de Gabory, Vincent Patron, Francois-Régis Ferrand, Juliette Thariat","doi":"10.1002/alr.23433","DOIUrl":"https://doi.org/10.1002/alr.23433","url":null,"abstract":"<p><strong>Key points: </strong>Interpretation of surgical mapping is essential for postoperative radiotherapy planning. Operative and pathological reports lack comprehensive information on margins quality and tissue block mapping. Standardizing reports is essential to reduce uncertainties, aiming for less morbid poRT.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: Confounders in the association between olfactory subdomains and frailty 回复:嗅觉亚域与虚弱之间关系的干扰因素。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-20 DOI: 10.1002/alr.23430
Michael Z Cheng MD, Varun Vohra BS, Hang Wang MS, Akhil Katuri BS, Jackie Langdon MS, Qian-Li Xue PhD, Nicholas R Rowan MD
{"title":"Reply to: Confounders in the association between olfactory subdomains and frailty","authors":"Michael Z Cheng MD,&nbsp;Varun Vohra BS,&nbsp;Hang Wang MS,&nbsp;Akhil Katuri BS,&nbsp;Jackie Langdon MS,&nbsp;Qian-Li Xue PhD,&nbsp;Nicholas R Rowan MD","doi":"10.1002/alr.23430","DOIUrl":"10.1002/alr.23430","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: “Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma”: The utility of topical cidofovir 答复"局部注射西多福韦治疗多灶性鼻窦外生乳头状瘤":局部西多福韦的效用。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-20 DOI: 10.1002/alr.23436
Florian Chatelet MD, MPH, Alessandro Vinciguerra, Morgane Marc, Benjamin Verillaud, Philippe Herman
{"title":"Reply to: “Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma”: The utility of topical cidofovir","authors":"Florian Chatelet MD, MPH,&nbsp;Alessandro Vinciguerra,&nbsp;Morgane Marc,&nbsp;Benjamin Verillaud,&nbsp;Philippe Herman","doi":"10.1002/alr.23436","DOIUrl":"10.1002/alr.23436","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of induction chemotherapy in advanced-stage olfactory neuroblastoma. 诱导化疗在晚期嗅神经母细胞瘤中的作用。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-20 DOI: 10.1002/alr.23428
Sung-Woo Cho, Bhumsuk Keam, Keun-Wook Lee, Ji-Won Kim, Doo Hee Han, Hyun Jik Kim, Jeong-Whun Kim, Dong-Young Kim, Chae-Seo Rhee, Yun Jung Bae, Ji-Hoon Kim, Keun-Yong Eom, Hong-Gyun Wu, Yong Hwy Kim, Chae-Yong Kim, Sun Ha Paek, Hyojin Kim, Tae-Bin Won

Objectives: To evaluate the treatment outcomes in patients with advanced-stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC).

Materials and methods: The clinical data of 38 patients with advanced-stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.1. Patients with complete remission or partial remission were defined as responders.

Results: Seventeen (44.7%) patients responded to IC. The response rate was higher in patients with high Hyams grade tumor (III/IV) compared to those with low-grade tumors (I/II) (60% vs. 22.2%, p = 0.038). Overall, the 5-year cancer-specific survival (CSS) rate was 76.0%. Among nonresponders to IC, a significant difference in 5-year CSS rates was observed between surgery with adjuvant radiotherapy (RT) (100%) versus definitive RT or chemoradiotherapy (CRT) (68.6%) (log-rank p = 0.006). However, for responders, there was no significant difference in 5-year CSS rates between surgery with adjuvant therapy (75%) and definitive RT or CRT (51.1%) (log-rank p = 0.536). When only high-grade tumors were considered among responders, the 5-year CSS rate was significantly higher in patients who received RT or CRT (51.4%) compared to those who underwent surgery with adjuvant therapy (0%) (log-rank p = 0.008).

Conclusion: In advanced-stage ONB, RT or CRT may be preferable for high-grade tumor responding to IC. Higher response rate and a potential role for induction IC in determining the optimal definitive treatment modality suggest a positive role for advanced-stage high-grade ONB.

摘要评估接受诱导化疗(IC)的晚期嗅神经母细胞瘤(ONB)患者的治疗效果:回顾性分析38例接受初始诱导化疗的晚期嗅神经母细胞瘤患者的临床数据。反应采用实体瘤反应评估标准 1.1 版进行定义。完全缓解或部分缓解的患者被定义为应答者:结果:17 名患者(44.7%)对 IC 有反应。与低分级肿瘤(I/II)患者相比,高Hyams分级肿瘤(III/IV)患者的应答率更高(60% vs. 22.2%,p = 0.038)。总体而言,5年癌症特异性生存率(CSS)为76.0%。在对 IC 无应答者中,手术加辅助放疗(RT)(100%)与最终 RT 或化学放疗(CRT)(68.6%)的 5 年 CSS 率存在显著差异(log-rank p = 0.006)。然而,就有反应者而言,手术加辅助治疗(75%)与明确RT或CRT(51.1%)的5年CSS率没有显著差异(log-rank p = 0.536)。如果只考虑有反应者中的高级别肿瘤,接受RT或CRT治疗的患者的5年CSS率(51.4%)明显高于接受手术辅助治疗的患者(0%)(log-rank p = 0.008):结论:对于晚期ONB,RT或CRT可能是对IC有反应的高级别肿瘤的首选。较高的反应率和诱导 IC 在确定最佳最终治疗方式方面的潜在作用表明,它对晚期高级别 ONB 有积极作用。
{"title":"Role of induction chemotherapy in advanced-stage olfactory neuroblastoma.","authors":"Sung-Woo Cho, Bhumsuk Keam, Keun-Wook Lee, Ji-Won Kim, Doo Hee Han, Hyun Jik Kim, Jeong-Whun Kim, Dong-Young Kim, Chae-Seo Rhee, Yun Jung Bae, Ji-Hoon Kim, Keun-Yong Eom, Hong-Gyun Wu, Yong Hwy Kim, Chae-Yong Kim, Sun Ha Paek, Hyojin Kim, Tae-Bin Won","doi":"10.1002/alr.23428","DOIUrl":"https://doi.org/10.1002/alr.23428","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the treatment outcomes in patients with advanced-stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC).</p><p><strong>Materials and methods: </strong>The clinical data of 38 patients with advanced-stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.1. Patients with complete remission or partial remission were defined as responders.</p><p><strong>Results: </strong>Seventeen (44.7%) patients responded to IC. The response rate was higher in patients with high Hyams grade tumor (III/IV) compared to those with low-grade tumors (I/II) (60% vs. 22.2%, p = 0.038). Overall, the 5-year cancer-specific survival (CSS) rate was 76.0%. Among nonresponders to IC, a significant difference in 5-year CSS rates was observed between surgery with adjuvant radiotherapy (RT) (100%) versus definitive RT or chemoradiotherapy (CRT) (68.6%) (log-rank p = 0.006). However, for responders, there was no significant difference in 5-year CSS rates between surgery with adjuvant therapy (75%) and definitive RT or CRT (51.1%) (log-rank p = 0.536). When only high-grade tumors were considered among responders, the 5-year CSS rate was significantly higher in patients who received RT or CRT (51.4%) compared to those who underwent surgery with adjuvant therapy (0%) (log-rank p = 0.008).</p><p><strong>Conclusion: </strong>In advanced-stage ONB, RT or CRT may be preferable for high-grade tumor responding to IC. Higher response rate and a potential role for induction IC in determining the optimal definitive treatment modality suggest a positive role for advanced-stage high-grade ONB.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxymetazoline as a predictor of turbinate reduction surgery outcomes: Objective support from a prospective, single-blinded, computational fluid dynamics study. 羟甲唑啉是鼻甲缩小手术效果的预测因子:前瞻性、单盲、计算流体动力学研究的客观支持。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-12 DOI: 10.1002/alr.23422
Zachary T Root, Zhenxing Wu, Thomas J Lepley, Aspen R Schneller, Robbie J Chapman, Veronica L Formanek, Kathleen M Kelly, Bradley A Otto, Kai Zhao

Background: A patient's subjective response to topical nasal decongestant is often used to screen for turbinate reduction surgery suitability. However, this anecdotal strategy has not been objectively and quantitatively evaluated.

Methods: Prospective, longitudinal, and single-blinded cohort study employing computational fluid dynamic modeling based on computed tomography scans at baseline, 30 min postoxymetazoline, and 2 months postsurgery on 11 patients with chronic turbinate hypertrophy.

Results: Nasal obstruction symptom evaluation (NOSE) and visual analogue scale (VAS) obstruction scores significantly improved from baseline to postoxymetazoline and again to postsurgery (NOSE: 71.82 ± 14.19 to 42.27 ± 25.26 to 22.27 ± 21.04; VAS: 6.09 ± 2.41 to 4.14 ± 2.20 to 2.08 ± 1.56; each interaction p < 0.05), with significant correlation between the latter two states (r∼0.37-0.69, p < 0.05). Oxymetazoline had a broader anatomical impact throughout inferior and middle turbinates than surgery (many p < 0.05); however, the improvement in regional airflow is similar (most p > 0.05) and predominantly surrounding the inferior turbinate. Strong postoxymetazoline to postsurgery correlations were observed in decreased nasal resistance (r = 0.79, p < 0.05), increased regional airflow rates (r = -0.47 to -0.55, p < 0.05) and regional air/mucosa shear force and heat flux (r = 0.43 to 0.58, p < 0.05); however, only increasing peak heat flux significantly correlated to symptom score improvement (NOSE: r = 0.48, p < 0.05).

Conclusion: We present the first objective evidence that the "topical decongestant test" can help predict turbinate reduction surgery outcomes. The predictive effect is driven by similar improvementin regional airflow that leading to improved air/mucosa stimulations (peak heat flux) rather than through reduced nasal resistance.

背景:患者对外用鼻腔减充血剂的主观反应通常被用来筛选鼻甲缩小手术的适宜性。然而,这一传闻策略尚未得到客观、定量的评估:方法:对 11 名慢性鼻甲肥大患者进行前瞻性、纵向和单盲队列研究,根据基线、术后 30 分钟和术后 2 个月的计算机断层扫描结果建立计算流体动力学模型:鼻阻塞症状评估(NOSE)和视觉模拟量表(VAS)阻塞评分从基线到奥美拉唑啉术后,再到手术后均明显改善(NOSE:71.82 ± 14.19 至 42.27 ± 25.26 至 22.27 ± 21.04;VAS:6.09 ± 2.41 至 4.14 ± 2.20 至 2.08 ± 1.56;各交互作用 p 0.05),且主要围绕下鼻甲。在鼻阻力下降方面,观察到了术后与术后的强相关性(r = 0.79,p 结论:术后鼻阻力下降与术后使用氧甲唑啉有关:我们首次提出了 "局部减充血剂试验 "有助于预测鼻甲缩小手术效果的客观证据。这种预测效果是由于区域气流的类似改善导致空气/粘膜刺激(热通量峰值)的改善,而不是通过鼻阻力的降低。
{"title":"Oxymetazoline as a predictor of turbinate reduction surgery outcomes: Objective support from a prospective, single-blinded, computational fluid dynamics study.","authors":"Zachary T Root, Zhenxing Wu, Thomas J Lepley, Aspen R Schneller, Robbie J Chapman, Veronica L Formanek, Kathleen M Kelly, Bradley A Otto, Kai Zhao","doi":"10.1002/alr.23422","DOIUrl":"https://doi.org/10.1002/alr.23422","url":null,"abstract":"<p><strong>Background: </strong>A patient's subjective response to topical nasal decongestant is often used to screen for turbinate reduction surgery suitability. However, this anecdotal strategy has not been objectively and quantitatively evaluated.</p><p><strong>Methods: </strong>Prospective, longitudinal, and single-blinded cohort study employing computational fluid dynamic modeling based on computed tomography scans at baseline, 30 min postoxymetazoline, and 2 months postsurgery on 11 patients with chronic turbinate hypertrophy.</p><p><strong>Results: </strong>Nasal obstruction symptom evaluation (NOSE) and visual analogue scale (VAS) obstruction scores significantly improved from baseline to postoxymetazoline and again to postsurgery (NOSE: 71.82 ± 14.19 to 42.27 ± 25.26 to 22.27 ± 21.04; VAS: 6.09 ± 2.41 to 4.14 ± 2.20 to 2.08 ± 1.56; each interaction p < 0.05), with significant correlation between the latter two states (r∼0.37-0.69, p < 0.05). Oxymetazoline had a broader anatomical impact throughout inferior and middle turbinates than surgery (many p < 0.05); however, the improvement in regional airflow is similar (most p > 0.05) and predominantly surrounding the inferior turbinate. Strong postoxymetazoline to postsurgery correlations were observed in decreased nasal resistance (r = 0.79, p < 0.05), increased regional airflow rates (r = -0.47 to -0.55, p < 0.05) and regional air/mucosa shear force and heat flux (r = 0.43 to 0.58, p < 0.05); however, only increasing peak heat flux significantly correlated to symptom score improvement (NOSE: r = 0.48, p < 0.05).</p><p><strong>Conclusion: </strong>We present the first objective evidence that the \"topical decongestant test\" can help predict turbinate reduction surgery outcomes. The predictive effect is driven by similar improvementin regional airflow that leading to improved air/mucosa stimulations (peak heat flux) rather than through reduced nasal resistance.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and characterization of microplastics in human nasal samples. 人类鼻腔样本中微塑料的鉴定和特征描述。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-07 DOI: 10.1002/alr.23427
Hyun Jin Min, Kyung Soo Kim, Hyunjung Kim, Jiyoung Gong, Jinyoung Jeong

Key points: Human nasal cavity samples were collected, and presence of microplastics were evaluated. Microplastics were present, and major types were polyethylene, polyester, acrylic polymer, and polypropylene. Further research is needed regarding microplastics and its clinical impact on human nasal cavity.

要点采集人体鼻腔样本,评估其中是否含有微塑料。结果显示存在微塑料,主要类型有聚乙烯、聚酯、丙烯酸聚合物和聚丙烯。需要进一步研究微塑料及其对人体鼻腔的临床影响。
{"title":"Identification and characterization of microplastics in human nasal samples.","authors":"Hyun Jin Min, Kyung Soo Kim, Hyunjung Kim, Jiyoung Gong, Jinyoung Jeong","doi":"10.1002/alr.23427","DOIUrl":"https://doi.org/10.1002/alr.23427","url":null,"abstract":"<p><strong>Key points: </strong>Human nasal cavity samples were collected, and presence of microplastics were evaluated. Microplastics were present, and major types were polyethylene, polyester, acrylic polymer, and polypropylene. Further research is needed regarding microplastics and its clinical impact on human nasal cavity.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-operative outcomes of primary benign orbital tumor resection are independent of tumor size and morphology. 原发性良性眼眶肿瘤切除术的术后效果与肿瘤大小和形态无关。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-07 DOI: 10.1002/alr.23423
Angela S Zhu, Ryan A Bartholomew, Yan Zhao, Margaret B Mitchell, Benjamin S Bleier, Barak Ringel

Key points: Using 3D modeling, we studied the influence of orbital tumor morphology on post-operative outcomes. Orbital tumor volume did not influence postoperative complication rates. Less spherical tumors may be correlated with a more extensive surgical approach.

要点:通过三维建模,我们研究了眼眶肿瘤形态对术后效果的影响。眼眶肿瘤体积对术后并发症发生率没有影响。较小的球形肿瘤可能与更大范围的手术方法有关。
{"title":"Post-operative outcomes of primary benign orbital tumor resection are independent of tumor size and morphology.","authors":"Angela S Zhu, Ryan A Bartholomew, Yan Zhao, Margaret B Mitchell, Benjamin S Bleier, Barak Ringel","doi":"10.1002/alr.23423","DOIUrl":"https://doi.org/10.1002/alr.23423","url":null,"abstract":"<p><strong>Key points: </strong>Using 3D modeling, we studied the influence of orbital tumor morphology on post-operative outcomes. Orbital tumor volume did not influence postoperative complication rates. Less spherical tumors may be correlated with a more extensive surgical approach.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal virus infection induces asthma exacerbation through B-cell-dependent recruitment of inflammatory monocytes. 鼻腔病毒感染通过 B 细胞依赖性炎症单核细胞招募诱发哮喘恶化。
IF 7.2 2区 医学 Q1 OTORHINOLARYNGOLOGY Pub Date : 2024-08-07 DOI: 10.1002/alr.23426
Kody A Waldstein, Arman Issimov, Maria Ganama, Valerie Jinge, Stephen Tilley, Xiaoyang Hua

Background: Upper respiratory viral infections (URVIs) are responsible for 80% of asthma exacerbation episodes. However, the underlying mechanisms remain poorly understood.

Methods: In this study, we used a mouse model of URVI and examined the impact of URVI on asthma phenotypes and the underlying mechanisms.

Results: Previously, we have reported that nasal-restricted infection with respiratory syncytial virus (RSV) only produces mild sino-nasal inflammation and mucus production, without causing direct lung infection. However, such nasal-restricted infection dramatically enhanced TH2 and TH17 inflammatory responses in the lungs and increased airway hyperresponsiveness (AHR) in mice with house dust mite (HDM)-induced asthma. Additionally, nasal-restricted infection with RSV recruited Ly6C+ inflammatory monocytes (IMs) into the lungs of mice with and without HDM-induced asthma. The expression of monocyte chemokines, including CCL2 and CCL7, also increased. Interestingly, nasal virus infection-induced AHR was abolished in mice depleted of IMs and in CCR2-/- mice, indicating that the recruited IMs play a key role in nasal virus infection-induced asthma exacerbations in mice. Lastly, we observed that recruitment of Ly6C+ IMs following URVI was abolished in mice lacking B cells and that nasal-restricted infection with RSV increased numbers of CCL2+CCL7+ B cells in the lungs of mice as compared to controls.

Conclusions: Taken together, our data have shown that URVI enhances the allergic inflammatory response and AHR through a B cell‒monocyte regulatory axis.

背景:上呼吸道病毒感染(URVI)是80%哮喘加重发作的原因。然而,人们对其潜在机制仍然知之甚少:在这项研究中,我们使用了一种URVI小鼠模型,并研究了URVI对哮喘表型的影响及其内在机制:以前,我们曾报道过鼻腔感染呼吸道合胞病毒(RSV)仅会产生轻微的鼻腔炎症和粘液分泌,而不会引起直接的肺部感染。然而,在屋尘螨(HDM)诱导的哮喘小鼠中,这种鼻腔限制性感染会显著增强肺部的 TH2 和 TH17 炎症反应,并增加气道高反应性(AHR)。此外,RSV 的鼻腔限制性感染会将 Ly6C+ 炎性单核细胞(IMs)招募到有或没有 HDM 诱导哮喘的小鼠肺部。单核细胞趋化因子(包括 CCL2 和 CCL7)的表达也有所增加。有趣的是,鼻病毒感染诱导的哮喘逆流在去除了 IMs 的小鼠和 CCR2/-小鼠中被取消,这表明招募的 IMs 在鼻病毒感染诱导的小鼠哮喘恶化中发挥了关键作用。最后,我们观察到,在缺乏 B 细胞的小鼠中,URVI 后 Ly6C+ IMs 的招募被取消,与对照组相比,鼻腔限制性感染 RSV 会增加小鼠肺部 CCL2+CCL7+ B 细胞的数量:总之,我们的数据表明,URVI 通过 B 细胞-单核细胞调节轴增强了过敏性炎症反应和 AHR。
{"title":"Nasal virus infection induces asthma exacerbation through B-cell-dependent recruitment of inflammatory monocytes.","authors":"Kody A Waldstein, Arman Issimov, Maria Ganama, Valerie Jinge, Stephen Tilley, Xiaoyang Hua","doi":"10.1002/alr.23426","DOIUrl":"https://doi.org/10.1002/alr.23426","url":null,"abstract":"<p><strong>Background: </strong>Upper respiratory viral infections (URVIs) are responsible for 80% of asthma exacerbation episodes. However, the underlying mechanisms remain poorly understood.</p><p><strong>Methods: </strong>In this study, we used a mouse model of URVI and examined the impact of URVI on asthma phenotypes and the underlying mechanisms.</p><p><strong>Results: </strong>Previously, we have reported that nasal-restricted infection with respiratory syncytial virus (RSV) only produces mild sino-nasal inflammation and mucus production, without causing direct lung infection. However, such nasal-restricted infection dramatically enhanced T<sub>H</sub>2 and T<sub>H</sub>17 inflammatory responses in the lungs and increased airway hyperresponsiveness (AHR) in mice with house dust mite (HDM)-induced asthma. Additionally, nasal-restricted infection with RSV recruited Ly6C+ inflammatory monocytes (IMs) into the lungs of mice with and without HDM-induced asthma. The expression of monocyte chemokines, including CCL2 and CCL7, also increased. Interestingly, nasal virus infection-induced AHR was abolished in mice depleted of IMs and in CCR2<sup>-/-</sup> mice, indicating that the recruited IMs play a key role in nasal virus infection-induced asthma exacerbations in mice. Lastly, we observed that recruitment of Ly6C+ IMs following URVI was abolished in mice lacking B cells and that nasal-restricted infection with RSV increased numbers of CCL2+CCL7+ B cells in the lungs of mice as compared to controls.</p><p><strong>Conclusions: </strong>Taken together, our data have shown that URVI enhances the allergic inflammatory response and AHR through a B cell‒monocyte regulatory axis.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":null,"pages":null},"PeriodicalIF":7.2,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Forum of Allergy & Rhinology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1