Pub Date : 2020-07-25DOI: 10.14419/ijac.v8i1.30889
M. E. Ghanjaoui, I. Adraoui, A. Gammoun, L. Cervera, M. El Rhazi, M. de la Guardia
This study aimed to determine the total arsenic concentration in lipsticks and evaluate the potential health risks due to daily ingestion of this toxic element from this product. The samples were analyzed using atomic fluorescence spectrometry technique after mineralization and hydride generation (HG-AFS). The calibration curve is linear over a concentration range from 0.125 to 2 µg L-1 with a regression coefficient of the order of 0.9899. The limit of detection is reaches 3 ng g-1. The standard deviation is of the order of 4%.The accuracy of this method was evaluated by calculating the recoveries of additions of arsenic to three lipstick samples. These results indicate recovery rates between 91% and 98%. Finely, the results found demonstrate that the method used in this work is suitable for arsenic detection in lipsticks samples.
本研究旨在确定口红中砷的总浓度，并评估每日从该产品中摄入这种有毒元素所带来的潜在健康风险。矿化和氢化物生成后，采用原子荧光光谱法(HG-AFS)对样品进行分析。在0.125 ~ 2µg L-1的浓度范围内，校正曲线呈线性，回归系数为0.9899数量级。检测限为3 ng g-1。标准差约为4%。通过计算三种口红样品中砷的添加回收率，评价了该方法的准确性。结果表明，回收率在91% ~ 98%之间。结果表明，本方法适用于口红样品中砷的检测。
{"title":"Hydride generation atomic fluorescence spectrometry (HG-AFS) determination of total arsenic in lipstick","authors":"M. E. Ghanjaoui, I. Adraoui, A. Gammoun, L. Cervera, M. El Rhazi, M. de la Guardia","doi":"10.14419/ijac.v8i1.30889","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30889","url":null,"abstract":"This study aimed to determine the total arsenic concentration in lipsticks and evaluate the potential health risks due to daily ingestion of this toxic element from this product. The samples were analyzed using atomic fluorescence spectrometry technique after mineralization and hydride generation (HG-AFS). The calibration curve is linear over a concentration range from 0.125 to 2 µg L-1 with a regression coefficient of the order of 0.9899. The limit of detection is reaches 3 ng g-1. The standard deviation is of the order of 4%.The accuracy of this method was evaluated by calculating the recoveries of additions of arsenic to three lipstick samples. These results indicate recovery rates between 91% and 98%. Finely, the results found demonstrate that the method used in this work is suitable for arsenic detection in lipsticks samples. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81420117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-25DOI: 10.14419/ijac.v8i1.26278
A. Adeniyi, Sulaiman Wasiu Kayode, Akinyode Olakunle Abayomi
The physicochemical properties of the seed and fatty acid profile of the seed oil of Caesalpinia bonducella were analyzed in this study, using standard methods of the Association of Official Analytical Chemists (AOAC). The proximate composition was found as follows: Moisture (3.24%), crude fat (41.76%), crude protein (28.63%), crude fibre (4.35%), ash content (2.94%) and carbohydrate (19.08%). The total unsaturated fatty acids (57.36%) was more abundant than the total saturated ones (42.68%). The seed oil had a high level of linoleic acid (28.15%), followed by oleic (18.41%), stearic (13.83%) and palmitic (13.56%). Other fatty acids had less than 10% each. There was a high level of unsaturation (57.36%) with oleic and linoleic acids dominating all other fatty acids with a total of 46.56%. The percentage of essential fatty acids (linoleic & linolenic acids) (32.96%) was also high at about ⅓ of the total oil content. The total poly-unsaturated fatty acids (36.99%) was higher than those of mono-unsaturated (20.37%). The high level of poly-unsaturated fatty acids in the oil sample is an advantage as these are essential components of the diet of man. The good total unsaturated/saturated (or P/S) ratio of the oil, (i.e.1.344), makes it to be very nutritionally useful if adopted for domestic purposes.
{"title":"The nutritional potentials and the fatty acid profile of the seed and seed oil of Caesalpinia bonducella","authors":"A. Adeniyi, Sulaiman Wasiu Kayode, Akinyode Olakunle Abayomi","doi":"10.14419/ijac.v8i1.26278","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.26278","url":null,"abstract":"The physicochemical properties of the seed and fatty acid profile of the seed oil of Caesalpinia bonducella were analyzed in this study, using standard methods of the Association of Official Analytical Chemists (AOAC). The proximate composition was found as follows: Moisture (3.24%), crude fat (41.76%), crude protein (28.63%), crude fibre (4.35%), ash content (2.94%) and carbohydrate (19.08%). The total unsaturated fatty acids (57.36%) was more abundant than the total saturated ones (42.68%). The seed oil had a high level of linoleic acid (28.15%), followed by oleic (18.41%), stearic (13.83%) and palmitic (13.56%). Other fatty acids had less than 10% each. There was a high level of unsaturation (57.36%) with oleic and linoleic acids dominating all other fatty acids with a total of 46.56%. The percentage of essential fatty acids (linoleic & linolenic acids) (32.96%) was also high at about ⅓ of the total oil content. The total poly-unsaturated fatty acids (36.99%) was higher than those of mono-unsaturated (20.37%). The high level of poly-unsaturated fatty acids in the oil sample is an advantage as these are essential components of the diet of man. The good total unsaturated/saturated (or P/S) ratio of the oil, (i.e.1.344), makes it to be very nutritionally useful if adopted for domestic purposes. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85215391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-25DOI: 10.14419/ijac.v8i1.30753
Shreyas Parbat
In the present work, quantum chemical study of the harmful dye, metanil yellow is conducted. The optimized molecular geometry and harmonic vibrational frequencies of metanil yellow were calculated by DFT-B3LYP method with LANL2DZ basis set. The vibrational assignments were performed on the basis of the potential energy distribution (PED) of the vibrational modes. Infrared spectra and Bulk Raman spectra were also obtained and characteristic peaks for the title compound were studied. The nonlinear optical properties of the title compound were calculated and discussed. Dipole moment, polarizability and first-order hyperpolarizability of the title compound were reported in order to study nonlinear optical properties (NLO). HOMO-LUMO energy levels were also computed in order to get the bandgap energy. Global reactivity descriptors were calculated using the HOMO and LUMO to predict compound reactivity. UV–Vis spectrum of the title compound was calculated using TD–DFT method. The molecular orbital contributions were studied by density of states (DOSs). Mulliken atomic charges and atomic polar tensors (APT) on each atom were tabulated. A discussion of the vibrational energy of each mode is also presented in this article.
{"title":"Quantum chemical analysis of harmful dye 3-[ (4-anilinophenyl) diazenyl] benzenesulfonate, metanil yellow","authors":"Shreyas Parbat","doi":"10.14419/ijac.v8i1.30753","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30753","url":null,"abstract":"In the present work, quantum chemical study of the harmful dye, metanil yellow is conducted. The optimized molecular geometry and harmonic vibrational frequencies of metanil yellow were calculated by DFT-B3LYP method with LANL2DZ basis set. The vibrational assignments were performed on the basis of the potential energy distribution (PED) of the vibrational modes. Infrared spectra and Bulk Raman spectra were also obtained and characteristic peaks for the title compound were studied. The nonlinear optical properties of the title compound were calculated and discussed. Dipole moment, polarizability and first-order hyperpolarizability of the title compound were reported in order to study nonlinear optical properties (NLO). HOMO-LUMO energy levels were also computed in order to get the bandgap energy. Global reactivity descriptors were calculated using the HOMO and LUMO to predict compound reactivity. UV–Vis spectrum of the title compound was calculated using TD–DFT method. The molecular orbital contributions were studied by density of states (DOSs). Mulliken atomic charges and atomic polar tensors (APT) on each atom were tabulated. A discussion of the vibrational energy of each mode is also presented in this article. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89684634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-14DOI: 10.14419/ijac.v8i1.30712
Z. Y. Abba, S. M.Gumel, A. A.Idris, M. A.Ibrahim
The increased application of paint in coating industry for interior and exterior decoration and corrosion inhibition, has inspired research in paint formulations. However, due to the toxic effect of preparatory chemicals used in paints, and the restrictive environmental legislation, research efforts have been directed to a more green process. In this work colouring matter from Lawsonia inermis leaves were extracted using water and analyzed by TLC and FTIR spectroscopy. White emulsion paint was formulated using pigment volume concentration (PVC) of 0.07%, the colouring matter extract was dispersed providing colour for the paint. The paint produced with the natural colourant was found to have similar properties with the paint produced using commercial pigment. Paint produced with aqueous extract faded under exposure to 5000 watts Tungsten Lamp after 48 hours but showed excellent fastness to rubbing. The extract induced excellent brownish colouration in the paint which maintained excellent, opacity, adhesion and good water resistance.
{"title":"Formulation of Paint using Natural Pigment from Lawsonia Inermis Leaves","authors":"Z. Y. Abba, S. M.Gumel, A. A.Idris, M. A.Ibrahim","doi":"10.14419/ijac.v8i1.30712","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30712","url":null,"abstract":"The increased application of paint in coating industry for interior and exterior decoration and corrosion inhibition, has inspired research in paint formulations. However, due to the toxic effect of preparatory chemicals used in paints, and the restrictive environmental legislation, research efforts have been directed to a more green process. In this work colouring matter from Lawsonia inermis leaves were extracted using water and analyzed by TLC and FTIR spectroscopy. White emulsion paint was formulated using pigment volume concentration (PVC) of 0.07%, the colouring matter extract was dispersed providing colour for the paint. The paint produced with the natural colourant was found to have similar properties with the paint produced using commercial pigment. Paint produced with aqueous extract faded under exposure to 5000 watts Tungsten Lamp after 48 hours but showed excellent fastness to rubbing. The extract induced excellent brownish colouration in the paint which maintained excellent, opacity, adhesion and good water resistance. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87972377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-14DOI: 10.14419/ijac.v8i1.30676
Safiyya Ibrahim Abubakar, Muhammad Adamu Ibrahim, Muhammad Bashir Ibrahim
This study was aimed to evaluate the adsorption of Methyl orange (MO) onto raw maize cob (RMC) and maize cob activated carbon (MCAC) from aqueous solution using batch adsorption studies. The produced adsorbents were characterized by Scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR). The influence of contact time, dosage, concentration, temperature, and pH were investigated as well as Isotherm and Thermodynamic studies. Effect of contact time showed that Methyl orange adsorption were found to reach equilibrium within 125 and 110 minutes with optimum percentage removal of about 86.98% and 94.57% for raw maize cob and maize cob activated carbon respectively. The dye removal efficiency was found to increase with increasing initial dye concentration from 10 mg/L to 100 mg/L, and adsorption efficiency was found to be high at lower pH. However, increase in the dosage of the adsorbents lead to the increase in the adsorption process. The equilibrium adsorption data were analyzed using four adsorption models: Langmuir, Freundlich, Temkin, and D-R. The results revealed that MO with raw maize cob and maize cob activated carbon fit well to Freundlich with R2 value 0.977 and Temkin with R2 value 0.990 respectively and mean adsorption energy calculated from D-R shows it is physical adsorption and also values of enthalpy and Gibbs free energy proves that. Values of activation parameters such as free energy changes (∆G), enthalpy change (∆H) and entropy change (∆S) were calculated using Van't Hoff equation. All ∆G values were negative indicating that the adsorption was feasible and spontaneous. The result indicated that RMC and MCAC can be used for removal of MO from aqueous solution. The maize cob waste which is discarded as waste material was found to be effective adsorbent for the removal of Methyl orange dye from aqueous solution.
{"title":"Adsorption of Methyl Orange Dye onto Raw Maize Cob and Maize Cob Activated Carbon: Isotherms and Thermodynamic Studies","authors":"Safiyya Ibrahim Abubakar, Muhammad Adamu Ibrahim, Muhammad Bashir Ibrahim","doi":"10.14419/ijac.v8i1.30676","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30676","url":null,"abstract":"This study was aimed to evaluate the adsorption of Methyl orange (MO) onto raw maize cob (RMC) and maize cob activated carbon (MCAC) from aqueous solution using batch adsorption studies. The produced adsorbents were characterized by Scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR). The influence of contact time, dosage, concentration, temperature, and pH were investigated as well as Isotherm and Thermodynamic studies. Effect of contact time showed that Methyl orange adsorption were found to reach equilibrium within 125 and 110 minutes with optimum percentage removal of about 86.98% and 94.57% for raw maize cob and maize cob activated carbon respectively. The dye removal efficiency was found to increase with increasing initial dye concentration from 10 mg/L to 100 mg/L, and adsorption efficiency was found to be high at lower pH. However, increase in the dosage of the adsorbents lead to the increase in the adsorption process. The equilibrium adsorption data were analyzed using four adsorption models: Langmuir, Freundlich, Temkin, and D-R. The results revealed that MO with raw maize cob and maize cob activated carbon fit well to Freundlich with R2 value 0.977 and Temkin with R2 value 0.990 respectively and mean adsorption energy calculated from D-R shows it is physical adsorption and also values of enthalpy and Gibbs free energy proves that. Values of activation parameters such as free energy changes (∆G), enthalpy change (∆H) and entropy change (∆S) were calculated using Van't Hoff equation. All ∆G values were negative indicating that the adsorption was feasible and spontaneous. The result indicated that RMC and MCAC can be used for removal of MO from aqueous solution. The maize cob waste which is discarded as waste material was found to be effective adsorbent for the removal of Methyl orange dye from aqueous solution. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75053060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-14DOI: 10.14419/ijac.v8i1.30723
M. Mohammed El Amine, A. E. Ghanjaoui, A. Mandil, A. Ait Sidi Mou, R. Slimani
This review gives a general overview of High Performance Liquid Chromatography (HPLC) Method for the detection, the separation and the quantification of the active compounds from the organics matrices. A brief description of the instrumentation and the method devel-opment is provided. The principles of HPLC including different separation modes and detection methods for the quantitative analysis are summarized. Finely, the validation procedures in real samples are also described.
{"title":"High performance liquid chromatography quality control","authors":"M. Mohammed El Amine, A. E. Ghanjaoui, A. Mandil, A. Ait Sidi Mou, R. Slimani","doi":"10.14419/ijac.v8i1.30723","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30723","url":null,"abstract":"This review gives a general overview of High Performance Liquid Chromatography (HPLC) Method for the detection, the separation and the quantification of the active compounds from the organics matrices. A brief description of the instrumentation and the method devel-opment is provided. The principles of HPLC including different separation modes and detection methods for the quantitative analysis are summarized. Finely, the validation procedures in real samples are also described. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82800486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-04DOI: 10.14419/ijac.v8i1.30526
Alhassan S.I, Sule S.Y, M. R., R. H.I, Baso A.A, Sheshe F.A, Jafar S.C
Acetylation of gum Arabic was achieved using acetic anhydride as solvent. The ester group formed was confirmed by FTIR spectra having absorption band of 750 cm-1 – 700 cm-1. Viscometric study of the pure and acetylated samples was carried out. Relative viscosity of acetylated gum was found to be higher than that of the pure gum. Intrinsic viscosity was determined for the two samples using different plot methods taking Huggin’s plot as standard. The intrinsic viscosity was found to be 86.43 cm3/g and 64.59 cm3/g for acetylated and pure gum arabic respectively. Relative errors of other methods for the two samples was compared to that of Huggins and the plots that are most comparable to Huggins with relative errors less than 5% are; Martin, Lyon-Tobolsky, Staudinger-Heuer, Maron-Reznik and our proposed method. The proposed method which was a modification of the Kreiser method gave relative error less than 2 %, for both pure and modified gum. Whereas the Kreiser method gave relative error greater than 15 % for both methods. The critical concentration for the samples was found to be 0.0116 g/cm3 and 0.0155 g/cm3 for acetylated and pure gum respectively. This shows that there was no molecule-molecule entanglements during viscosity measurements.
{"title":"Comparative viscometric study of pure and acetylated gum Arabic using different plot methods","authors":"Alhassan S.I, Sule S.Y, M. R., R. H.I, Baso A.A, Sheshe F.A, Jafar S.C","doi":"10.14419/ijac.v8i1.30526","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30526","url":null,"abstract":"Acetylation of gum Arabic was achieved using acetic anhydride as solvent. The ester group formed was confirmed by FTIR spectra having absorption band of 750 cm-1 – 700 cm-1. Viscometric study of the pure and acetylated samples was carried out. Relative viscosity of acetylated gum was found to be higher than that of the pure gum. Intrinsic viscosity was determined for the two samples using different plot methods taking Huggin’s plot as standard. The intrinsic viscosity was found to be 86.43 cm3/g and 64.59 cm3/g for acetylated and pure gum arabic respectively. Relative errors of other methods for the two samples was compared to that of Huggins and the plots that are most comparable to Huggins with relative errors less than 5% are; Martin, Lyon-Tobolsky, Staudinger-Heuer, Maron-Reznik and our proposed method. The proposed method which was a modification of the Kreiser method gave relative error less than 2 %, for both pure and modified gum. Whereas the Kreiser method gave relative error greater than 15 % for both methods. The critical concentration for the samples was found to be 0.0116 g/cm3 and 0.0155 g/cm3 for acetylated and pure gum respectively. This shows that there was no molecule-molecule entanglements during viscosity measurements. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75825974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-04DOI: 10.14419/ijac.v8i1.30541
Ashok Kumar Sahoo, Sunil Kumar Pradhan, Ajaya Kumar Patnaik, S. Das
Molecular interaction studies using ultrasonic technique and spectroscopic investigation in ternary liquid mixture of drug 1,10-Phenanthroline, an α- amino acid Glycine and a transition metal salt like CuCl2 in aqueous medium has been carried out at 300.15K and 2 MHz frequency. Using experimental values of density (ρ),ultrasonic velocity (U) and UV analysis, different acoustical parameters such as adiabatic compressibility (β),intermolecular free length (Lf), acoustic impedance (z),relative association (RA),apparent molar volume (V∅), apparent molar adiabatic compressibility (K∅) are evaluated for the mixture of drug, glycine and inorganic salt CuCl2 at various concentrations. The ultrasonic and spectroscopic investigation clearly shows coordinative association of drug as a ligand with transition metal salt. Further interaction of glycine as an α- amino acid indicates a competitive association in the ternary system. The outcomes were expressed in terms of molecular interactions and the variation in parameters under varying solute concentrations providing conclusive remarks regarding the strength of intermolecular interactions in the ternary system with a bio-physical novelty.
{"title":"Study of ternary association of anti-microbial drug 1, 10-phenanthroline and α - amino acid with copper salt, an ultrasonic investigation of competitive interaction","authors":"Ashok Kumar Sahoo, Sunil Kumar Pradhan, Ajaya Kumar Patnaik, S. Das","doi":"10.14419/ijac.v8i1.30541","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30541","url":null,"abstract":"Molecular interaction studies using ultrasonic technique and spectroscopic investigation in ternary liquid mixture of drug 1,10-Phenanthroline, an α- amino acid Glycine and a transition metal salt like CuCl2 in aqueous medium has been carried out at 300.15K and 2 MHz frequency. Using experimental values of density (ρ),ultrasonic velocity (U) and UV analysis, different acoustical parameters such as adiabatic compressibility (β),intermolecular free length (Lf), acoustic impedance (z),relative association (RA),apparent molar volume (V∅), apparent molar adiabatic compressibility (K∅) are evaluated for the mixture of drug, glycine and inorganic salt CuCl2 at various concentrations. The ultrasonic and spectroscopic investigation clearly shows coordinative association of drug as a ligand with transition metal salt. Further interaction of glycine as an α- amino acid indicates a competitive association in the ternary system. The outcomes were expressed in terms of molecular interactions and the variation in parameters under varying solute concentrations providing conclusive remarks regarding the strength of intermolecular interactions in the ternary system with a bio-physical novelty. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81729108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.14419/ijac.v8i1.30549
K. Bello
The present study is aimed at designing a pullulan based hydrogel through grafting technique for slow release of fluorouracil drug. To achieve this, pullulan grafted acrylic acid was synthesized and characterized by FTIR, and FESEM analyses. Swelling was done in different pH solutions with better swelling in pH 2. As such, the drug loading was done in the specified pH environment. The release profile revealed that more than 90 % of the drug could be released within 5 days. The prepared hydrogel may be considered as stimuli responsive materials for oral drug delivery of anti-cancer drugs.
{"title":"Synthesis and characterization of pullulan derived hydrogel matrix as carrier for slow release of anti-cancer drug","authors":"K. Bello","doi":"10.14419/ijac.v8i1.30549","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30549","url":null,"abstract":"The present study is aimed at designing a pullulan based hydrogel through grafting technique for slow release of fluorouracil drug. To achieve this, pullulan grafted acrylic acid was synthesized and characterized by FTIR, and FESEM analyses. Swelling was done in different pH solutions with better swelling in pH 2. As such, the drug loading was done in the specified pH environment. The release profile revealed that more than 90 % of the drug could be released within 5 days. The prepared hydrogel may be considered as stimuli responsive materials for oral drug delivery of anti-cancer drugs. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78969643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-15DOI: 10.14419/ijac.v8i1.30542
Likitha T G, J. Gnana Babu C., S. H G
A rapid, simple, precise and accurate high performance thin layer chromatographic method has been developed and validated for the estima-tion of Levetiracetam in bulk and tablet dosage form. The Levetiracetam was chromatographed on silica gel 60 F254 HPTLC plate as a sta-tionary phase. The mobile phase was Ethyl acetate: Methanol: Ammonia in the ratio of 7:1:2 respectively. It gave a dense and compact spot of Levetiracetam with an Rf value of 0.56. The quantitation was carried out at 210 nm. The method was validated in terms of linearity, accu-racy, precision and specificity. The statistical analysis proved that the developed method is accurate and reproducible with linearity in the range of 100 to 500 ng/spot. The limit of detection and limit of quantitation for Levetiracetam were 3.55 and 10.66 ng/spot respectively. The developed method can be employed for the routine analysis of Levetiracetam in the tablet dosage form.
{"title":"Validated HPTLC method for the quantitation of levetiracetam in pure and tablet dosage form","authors":"Likitha T G, J. Gnana Babu C., S. H G","doi":"10.14419/ijac.v8i1.30542","DOIUrl":"https://doi.org/10.14419/ijac.v8i1.30542","url":null,"abstract":"A rapid, simple, precise and accurate high performance thin layer chromatographic method has been developed and validated for the estima-tion of Levetiracetam in bulk and tablet dosage form. The Levetiracetam was chromatographed on silica gel 60 F254 HPTLC plate as a sta-tionary phase. The mobile phase was Ethyl acetate: Methanol: Ammonia in the ratio of 7:1:2 respectively. It gave a dense and compact spot of Levetiracetam with an Rf value of 0.56. The quantitation was carried out at 210 nm. The method was validated in terms of linearity, accu-racy, precision and specificity. The statistical analysis proved that the developed method is accurate and reproducible with linearity in the range of 100 to 500 ng/spot. The limit of detection and limit of quantitation for Levetiracetam were 3.55 and 10.66 ng/spot respectively. The developed method can be employed for the routine analysis of Levetiracetam in the tablet dosage form.","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90704034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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