首页 > 最新文献

Scientific Inquiry and Review最新文献

英文 中文
Numerical Analysis of an SEIR Epidemic Model SEIR流行病模型的数值分析
Pub Date : 2023-03-15 DOI: 10.32350/sir.71.06
F. Dayan
This paper is concerned for the numerical methods of susceptible exposed infectious recovered (SEIR) epidemic model of Coronavirus disease factor. The model is handled numerically with three extraordinary numerical scheme, forward Euler, Runge-Kutta Plan (RK-4) and the proposed non-standard finite difference (NSFD) techniques. In epidemic model of infectious illnesses, energy is a demon omen property of the consistent framework since negative worth of a subpopulation is useless. The NSFD technique ends up being more important and trustable numerical system than forward Euler and RK-4 strategies. NSFD technique uses terrifically significant properties of tireless SEIR Coronavirus scourge model like energy and presence of equilibria while forward Euler and RK-4 systems can't hold these characteristics. Furthermore, the proposed NSFD is liberated from time step size while forward Euler and RK-4 depend upon the time step size. The numerical diversions with the aid of a numerical test is presented for the endorsements of the huge number of characteristics.
本文研究了冠状病毒病因子易感暴露感染恢复(SEIR)流行模型的数值方法。采用正演欧拉法、龙格-库塔法(RK-4)和提出的非标准有限差分法(NSFD)对模型进行了数值处理。在传染病的流行模型中,能量是一致框架的一个恶魔预兆属性,因为一个亚群的负值是无用的。NSFD技术最终成为比正向欧拉和RK-4策略更重要和可靠的数值系统。NSFD技术利用了不知疲倦的SEIR冠状病毒祸害模型的非常重要的特性,如能量和平衡的存在,而正向欧拉和RK-4系统不能保持这些特性。此外,所提出的NSFD不受时间步长的限制,而前向欧拉和RK-4依赖于时间步长。在数值试验的帮助下,提出了对大量特征的认可的数值偏移。
{"title":"Numerical Analysis of an SEIR Epidemic Model","authors":"F. Dayan","doi":"10.32350/sir.71.06","DOIUrl":"https://doi.org/10.32350/sir.71.06","url":null,"abstract":"This paper is concerned for the numerical methods of susceptible exposed infectious recovered (SEIR) epidemic model of Coronavirus disease factor. The model is handled numerically with three extraordinary numerical scheme, forward Euler, Runge-Kutta Plan (RK-4) and the proposed non-standard finite difference (NSFD) techniques. In epidemic model of infectious illnesses, energy is a demon omen property of the consistent framework since negative worth of a subpopulation is useless. The NSFD technique ends up being more important and trustable numerical system than forward Euler and RK-4 strategies. NSFD technique uses terrifically significant properties of tireless SEIR Coronavirus scourge model like energy and presence of equilibria while forward Euler and RK-4 systems can't hold these characteristics. Furthermore, the proposed NSFD is liberated from time step size while forward Euler and RK-4 depend upon the time step size. The numerical diversions with the aid of a numerical test is presented for the endorsements of the huge number of characteristics.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121784927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transmission Analysis of Hepatitis B Epidemic Model using Standard and Non-standard Schemes 采用标准方案和非标准方案的乙型肝炎流行模型传播分析
Pub Date : 2023-03-15 DOI: 10.32350/sir.71.04
I. Khan, M. Irfan, Azhar Iqbal, Amjid Hussain
Mathematical modeling is a vast field that has interdisciplinary implications for research. These models help to investigate the basic dynamics and quantitative behavior of infectious diseases that affect human beings, such as COVID-19, hepatitis B virus (HBV), and human immunodeficiency virus (HIV). The current study investigates the spread of HBV by using the basic virus model. In order to determine the stability of disease-free and endemic equilibria, the basic reproduction number is determined. The convergence and divergence of disease-free and endemic equilibria are demonstrated by using standard finite difference (SFD) and non-standard finite difference (NSFD) schemes. Arguably, SFD schemes, namely Euler and Runge-Kutta order four (RK-4) schemes, converge for lower step sizes, while the NSFD scheme converges for all step sizes. The latter is a strong, efficient, and reliable method that shows a clear picture of the continuous model. All the results are validated using numerical simulations in order to better comprehend the dynamics of the disease. The theoretical and numerical findings in this work can be applied as a useful tool for tracking the prevalence of HBV infectious disease.
数学建模是一个广泛的领域,具有跨学科的研究意义。这些模型有助于研究影响人类的传染病的基本动态和定量行为,如COVID-19,乙型肝炎病毒(HBV)和人类免疫缺陷病毒(HIV)。本研究采用基本病毒模型研究HBV的传播。为了确定无病和地方性平衡的稳定性,确定了基本繁殖数。用标准有限差分(SFD)和非标准有限差分(NSFD)格式证明了无病平衡和地方性平衡的收敛性和发散性。可以说,SFD格式,即Euler和Runge-Kutta四阶(RK-4)格式,对较低步长收敛,而NSFD格式对所有步长收敛。后者是一种强大、高效、可靠的方法,可以清晰地显示连续模型的图像。所有的结果都用数值模拟来验证,以便更好地理解疾病的动力学。这项工作的理论和数值结果可以作为跟踪HBV传染病流行的有用工具。
{"title":"Transmission Analysis of Hepatitis B Epidemic Model using Standard and Non-standard Schemes","authors":"I. Khan, M. Irfan, Azhar Iqbal, Amjid Hussain","doi":"10.32350/sir.71.04","DOIUrl":"https://doi.org/10.32350/sir.71.04","url":null,"abstract":"Mathematical modeling is a vast field that has interdisciplinary implications for research. These models help to investigate the basic dynamics and quantitative behavior of infectious diseases that affect human beings, such as COVID-19, hepatitis B virus (HBV), and human immunodeficiency virus (HIV). The current study investigates the spread of HBV by using the basic virus model. In order to determine the stability of disease-free and endemic equilibria, the basic reproduction number is determined. The convergence and divergence of disease-free and endemic equilibria are demonstrated by using standard finite difference (SFD) and non-standard finite difference (NSFD) schemes. Arguably, SFD schemes, namely Euler and Runge-Kutta order four (RK-4) schemes, converge for lower step sizes, while the NSFD scheme converges for all step sizes. The latter is a strong, efficient, and reliable method that shows a clear picture of the continuous model. All the results are validated using numerical simulations in order to better comprehend the dynamics of the disease. The theoretical and numerical findings in this work can be applied as a useful tool for tracking the prevalence of HBV infectious disease.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121722830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring the Awareness of Polycystic Ovarian Syndrome (PCOS) among Women in Punjab, Pakistan 测量巴基斯坦旁遮普省妇女对多囊卵巢综合征(PCOS)的认识
Pub Date : 2023-03-15 DOI: 10.32350/sir.71.01
Alina Rafique, U. Salma, Hafiz Ghulam Murtaza Saleem
Polycystic ovarian syndrome (PCOS) is the most prevailing endocrine disorder among women of reproductive age, worldwide. Its prevalence is 52% in Pakistani women and the rate of infertility is gradually increasing. It can be treated through early diagnosis, management of symptoms, and a healthy lifestyle. This cross-sectional study aimed to determine the level of awareness and knowledge regarding PCOS in the women of Punjab, Pakistan. For this purpose, a total of 350 women between the ages of 16 and 50 years were included in the current study. data was obtained through a questionnaire and analyzed through SPSS (version 25). The results determined that 56% of women were found to have the knowledge of PCOS, while 44% had never heard about it. Furthermore, about 67% of 196 PCOS-aware women were unaware of its signs and symptoms. Moreover, in 14% of the cases, a friend was the source of knowledge regarding PCOS. Whereas, approximately 10% of these women had heard about the syndrome through education, 9% through their family, 7% through various media such as newspapers, television, and social media, and 17% through other sources including general physicians and gynecologists. It was concluded that only 33% of the participants who claimed to have heard of PCOS were aware of its symptoms, whereas 67% were unaware of them. A total of 152 women, out of 350, had never heard about PCOS.
多囊卵巢综合征(PCOS)是世界范围内最常见的育龄妇女内分泌疾病。其在巴基斯坦妇女中的患病率为52%,不孕率正在逐渐增加。它可以通过早期诊断、控制症状和健康的生活方式来治疗。本横断面研究旨在确定巴基斯坦旁遮普省妇女对多囊卵巢综合征的认识和知识水平。为此目的,目前的研究共纳入了350名年龄在16至50岁之间的妇女。数据通过问卷调查获得,并通过SPSS (version 25)进行分析。结果表明,56%的女性对多囊卵巢综合征有所了解,44%的女性从未听说过多囊卵巢综合征。此外,196名知道多囊卵巢综合征的妇女中约有67%不知道其体征和症状。此外,在14%的病例中,朋友是多囊卵巢综合征的知识来源。然而,这些女性中大约有10%是通过教育听说这种综合征的,9%是通过家人,7%是通过各种媒体,如报纸,电视和社交媒体,17%是通过其他来源,包括普通医生和妇科医生。结论是,在声称听说过多囊卵巢综合征的参与者中,只有33%的人知道其症状,而67%的人不知道。350名女性中有152名从未听说过多囊卵巢综合征。
{"title":"Measuring the Awareness of Polycystic Ovarian Syndrome (PCOS) among Women in Punjab, Pakistan","authors":"Alina Rafique, U. Salma, Hafiz Ghulam Murtaza Saleem","doi":"10.32350/sir.71.01","DOIUrl":"https://doi.org/10.32350/sir.71.01","url":null,"abstract":"Polycystic ovarian syndrome (PCOS) is the most prevailing endocrine disorder among women of reproductive age, worldwide. Its prevalence is 52% in Pakistani women and the rate of infertility is gradually increasing. It can be treated through early diagnosis, management of symptoms, and a healthy lifestyle. This cross-sectional study aimed to determine the level of awareness and knowledge regarding PCOS in the women of Punjab, Pakistan. For this purpose, a total of 350 women between the ages of 16 and 50 years were included in the current study. data was obtained through a questionnaire and analyzed through SPSS (version 25). The results determined that 56% of women were found to have the knowledge of PCOS, while 44% had never heard about it. Furthermore, about 67% of 196 PCOS-aware women were unaware of its signs and symptoms. Moreover, in 14% of the cases, a friend was the source of knowledge regarding PCOS. Whereas, approximately 10% of these women had heard about the syndrome through education, 9% through their family, 7% through various media such as newspapers, television, and social media, and 17% through other sources including general physicians and gynecologists. It was concluded that only 33% of the participants who claimed to have heard of PCOS were aware of its symptoms, whereas 67% were unaware of them. A total of 152 women, out of 350, had never heard about PCOS.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133818283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monotone Data Modelling Using Rational Cubic Fractal Interpolation Function 基于有理三次分形插值函数的单调数据建模
Pub Date : 2023-03-15 DOI: 10.32350/sir.71.02
Tayba Arooj, Farheen Ibraheem, M. Hussain
Geometric modelling of several intricate and complex structures such as trees, mountains, clouds, ferns, geographic topography, and coastlines is challenging in computer graphics. Traditional splines such astrigonometric, polynomial, exponential, and rational fail to simulate this significant class of complex structures, which are highly irregular in nature. For this purpose, this research develops a novel cutting-edgemethod for synthesizing and modelling structures. The proposed technique; C 1 fractal interpolation function (FIF) builds an iterated function system (IFS) by integrating fractal calculus and rational cubic polynomial functions. Appropriate conditions on scaling and shape parameters are derived to help maintain the inherited shape qualities of the data. Experiments in numerous scientific domains, such as the pharmaceutical and chemical industries have been presented as an example, to confirm the usefulness of the suggested model. Moreover, the graphic results demonstrated that the developed monotone hybrid model (MHM) offers a heterogeneous method for gathering data with a monotone structure.
在计算机图形学中,对树木、山、云、蕨类植物、地理地形和海岸线等几种复杂结构的几何建模是具有挑战性的。传统的样条曲线,如星形曲线、多项式曲线、指数曲线和理性曲线,无法模拟这类复杂结构,因为它们在本质上是高度不规则的。为此,本研究开发了一种新的前沿结构合成和建模方法。提出的技术;分形插值函数(fiif)通过对分形微积分和有理三次多项式函数的积分,构建了一个迭代函数系统。导出了适当的缩放条件和形状参数,以保持数据的继承形状质量。在许多科学领域,例如制药和化学工业中进行的实验已作为一个例子,以证实所建议模型的有效性。此外,图形结果表明,所建立的单调混合模型(MHM)为具有单调结构的数据采集提供了一种异构方法。
{"title":"Monotone Data Modelling Using Rational Cubic Fractal Interpolation Function","authors":"Tayba Arooj, Farheen Ibraheem, M. Hussain","doi":"10.32350/sir.71.02","DOIUrl":"https://doi.org/10.32350/sir.71.02","url":null,"abstract":"Geometric modelling of several intricate and complex structures such as trees, mountains, clouds, ferns, geographic topography, and coastlines is challenging in computer graphics. Traditional splines such astrigonometric, polynomial, exponential, and rational fail to simulate this significant class of complex structures, which are highly irregular in nature. For this purpose, this research develops a novel cutting-edgemethod for synthesizing and modelling structures. The proposed technique; C 1 fractal interpolation function (FIF) builds an iterated function system (IFS) by integrating fractal calculus and rational cubic polynomial functions. Appropriate conditions on scaling and shape parameters are derived to help maintain the inherited shape qualities of the data. Experiments in numerous scientific domains, such as the pharmaceutical and chemical industries have been presented as an example, to confirm the usefulness of the suggested model. Moreover, the graphic results demonstrated that the developed monotone hybrid model (MHM) offers a heterogeneous method for gathering data with a monotone structure.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128891827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOPSIS Technique of MCDM under Cubic Intuitionistic Fuzzy Soft Set Environment 三次直觉模糊软集环境下MCDM的TOPSIS技术
Pub Date : 2023-03-15 DOI: 10.32350/sir.71.03
M. Saqlain, Raiha Imran, Sabahat Hassan
A powerful tool for dealing with ambiguity, attributive values, fuzziness, and inconsistency is the cubic intuitionistic fuzzy soft set. In this paper, multi-criteria group decision-making (MCGDM) technique called extended TOPSIS based on distance and similarity measures is presented. Furthermore, a real-world problem is resolved by applying CIFS-set to support the theoretical visualization. Arguably, the proposed technique works well and has practical uses.
三次直觉模糊软集是处理歧义、属性值、模糊性和不一致性的有力工具。本文提出了一种基于距离和相似度量的多准则群体决策(MCGDM)技术——扩展TOPSIS。此外,通过应用CIFS-set来支持理论可视化,解决了实际问题。可以说,所提出的技术工作良好,具有实际用途。
{"title":"TOPSIS Technique of MCDM under Cubic Intuitionistic Fuzzy Soft Set Environment","authors":"M. Saqlain, Raiha Imran, Sabahat Hassan","doi":"10.32350/sir.71.03","DOIUrl":"https://doi.org/10.32350/sir.71.03","url":null,"abstract":"A powerful tool for dealing with ambiguity, attributive values, fuzziness, and inconsistency is the cubic intuitionistic fuzzy soft set. In this paper, multi-criteria group decision-making (MCGDM) technique called extended TOPSIS based on distance and similarity measures is presented. Furthermore, a real-world problem is resolved by applying CIFS-set to support the theoretical visualization. Arguably, the proposed technique works well and has practical uses.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131998815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Existence of Fault-tolerant numbers of Two-Bridge Knots 关于双桥结容错数的存在性
Pub Date : 2022-12-07 DOI: 10.32350/sir.64.05
Usman Ali, I. F. Hussain, A. Rani
In this write-up, we explore the family of two-bridge knots for fault-tolerance. We findout fault-tolerant unknotting numbers for certain subfamilies of two-bridge knots. Besidesthis, we work out on special subfamilies C(a, a1, a2, a3, . . . ,±2,−ak,−ak−1, . . . ,−a2,−a1)and C(2n, 3) of two-bridge knots with unknotting number 1 and n respectively and found avarient of fault-tolerant unknotting number called restricetd fault-tolerant unknotting number.Lastly, this paper is concluded by explicating biological disposition of fault-tolerantunknotting number in terms of enzyme action on DNA.
在这篇文章中,我们探讨了用于容错的双桥结族。我们得到了双桥结的某些亚族的容错解结数。除此之外,我们还计算了特殊的子族C(a, a1, a2, a3,…)。,±2,−ak,−ak−1,…,−a2,−a1)和C(2n, 3),分别为解结数为1和n的双桥结,并找到了容错解结数的一种变体,称为限制容错解结数。最后,从酶对DNA的作用角度阐述了容错解结数的生物学特性。
{"title":"On the Existence of Fault-tolerant numbers of Two-Bridge Knots","authors":"Usman Ali, I. F. Hussain, A. Rani","doi":"10.32350/sir.64.05","DOIUrl":"https://doi.org/10.32350/sir.64.05","url":null,"abstract":"In this write-up, we explore the family of two-bridge knots for fault-tolerance. We findout fault-tolerant unknotting numbers for certain subfamilies of two-bridge knots. Besidesthis, we work out on special subfamilies C(a, a1, a2, a3, . . . ,±2,−ak,−ak−1, . . . ,−a2,−a1)and C(2n, 3) of two-bridge knots with unknotting number 1 and n respectively and found avarient of fault-tolerant unknotting number called restricetd fault-tolerant unknotting number.Lastly, this paper is concluded by explicating biological disposition of fault-tolerantunknotting number in terms of enzyme action on DNA.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127810527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-silico evaluation of the genes and proteins involved in bacterial bio-plastic production pathways 参与细菌生物塑料生产途径的基因和蛋白质的计算机评价
Pub Date : 2022-12-07 DOI: 10.32350/sir.64.03
Hamza Abbas Jaffari, Q. Abbas, H. Z. Wadood
Plastic pollution is a worldwide concern endangering both fossil fuel resources and the environment through rise in their production and usage. Bioplastics emerged as a suitable replacement and proved more environment friendly than traditional plastics. Among bioplastics, polyhydroxyalkanoates (PHA) proved to be in demand due to their promising properties such as high rate of biodegradability. Three key genes (phaA, phaB, and phaC) are involved in the biosynthesis of PHA. An analysis based on bioinformatics approaches was performed in this study to analyze these key genes and their translated proteins in potential PHA producing microorganisms found on the Gen-solution database. The sequences (DNA and Protein) obtained from PHA producing microorganisms were analyzed in MEGA X to check their evolutionary history. The arrangement of genes was highly diverse. The PHA biosynthetic genes belonging to Proteobacteria showed promising phylogenetic relationship and the occurrence and their distribution in these organisms suggested that a single gene cluster related to PHA might have been segmented in the form of small groups of genes and got transferred among various organisms. The results indicated that the gene and protein sequences were not fully conserved suggesting that the genes had undergone addition, deletion or replacement of nucleotides resulting in gene rearrangement. However, the function of the proteins remained fully conserved suggesting that the protein function had the highest level of conservation and the gene sequences had the least level of conservation according to this study. Overall, the results were a strong indicative that horizontal gene transfer had a strong influence on the distribution and molecular evolution of these PHA biosynthetic genes.
塑料污染是一个全球性问题,由于其生产和使用的增加,危及化石燃料资源和环境。生物塑料作为一种合适的替代品出现,并被证明比传统塑料更环保。在生物塑料中,聚羟基烷酸酯(PHA)因其具有较高的生物降解率等特性而受到广泛的需求。三个关键基因(phaA, phaB和phaC)参与PHA的生物合成。本研究基于生物信息学方法对Gen-solution数据库中发现的潜在PHA产生微生物中的这些关键基因及其翻译蛋白进行了分析。从PHA产生微生物中获得的序列(DNA和蛋白质)在MEGA X中进行分析,以检查其进化史。基因排列是高度多样化的。变形杆菌属的PHA生物合成基因显示出良好的系统发育关系,它们在这些生物中的出现和分布表明,与PHA相关的单个基因簇可能以小群基因的形式被分割并在不同生物之间转移。结果表明,基因和蛋白序列不完全保守,表明基因发生了核苷酸的添加、删除或替换,导致基因重排。然而,蛋白质的功能仍然完全保守,这表明本研究中蛋白质功能的保守程度最高,而基因序列的保守程度最低。结果表明,水平基因转移对这些PHA生物合成基因的分布和分子进化具有重要影响。
{"title":"In-silico evaluation of the genes and proteins involved in bacterial bio-plastic production pathways","authors":"Hamza Abbas Jaffari, Q. Abbas, H. Z. Wadood","doi":"10.32350/sir.64.03","DOIUrl":"https://doi.org/10.32350/sir.64.03","url":null,"abstract":"Plastic pollution is a worldwide concern endangering both fossil fuel resources and the environment through rise in their production and usage. Bioplastics emerged as a suitable replacement and proved more environment friendly than traditional plastics. Among bioplastics, polyhydroxyalkanoates (PHA) proved to be in demand due to their promising properties such as high rate of biodegradability. Three key genes (phaA, phaB, and phaC) are involved in the biosynthesis of PHA. An analysis based on bioinformatics approaches was performed in this study to analyze these key genes and their translated proteins in potential PHA producing microorganisms found on the Gen-solution database. The sequences (DNA and Protein) obtained from PHA producing microorganisms were analyzed in MEGA X to check their evolutionary history. The arrangement of genes was highly diverse. The PHA biosynthetic genes belonging to Proteobacteria showed promising phylogenetic relationship and the occurrence and their distribution in these organisms suggested that a single gene cluster related to PHA might have been segmented in the form of small groups of genes and got transferred among various organisms. The results indicated that the gene and protein sequences were not fully conserved suggesting that the genes had undergone addition, deletion or replacement of nucleotides resulting in gene rearrangement. However, the function of the proteins remained fully conserved suggesting that the protein function had the highest level of conservation and the gene sequences had the least level of conservation according to this study. Overall, the results were a strong indicative that horizontal gene transfer had a strong influence on the distribution and molecular evolution of these PHA biosynthetic genes.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121267055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Bridge Graph by Means of K-Banhatti Sombor Invariants 用K-Banhatti Sombor不变量分析桥图
Pub Date : 2022-12-07 DOI: 10.32350/sir.64.01
Abaid ur Rehman Virk, Saba Iram
Any number that can be uniquely determined by a graph is called a graph invariant. During the last twenty years’ countless mathematical graph invariants have been characterized and utilized for correlation analysis. However, no reliable examination has been embraced to decide, how much these invariants are related with a network graph or molecular graph. In this paper, it will discuss three different variants of bridge networks with good potential of prediction in the field of computer science, mathematics, chemistry, pharmacy, informatics and biology in context with physical and chemical structures and networks, because K-Banhatti Sombor invariants are freshly presented and have numerous prediction qualities for different variants of bridge graphs or networks. These deduced results can be used for the modelling of computer networks like LAN, MAN, WAN, backbone of internet and other networks/structures of computers, power generation, bio-informatics and chemical compound.
任何可以由图唯一确定的数称为图不变量。在过去的二十年中,无数的数学图不变量被描述并用于相关分析。然而,目前还没有可靠的检验方法来确定这些不变量与网络图或分子图的关系。在本文中,它将讨论在物理和化学结构和网络的背景下,在计算机科学、数学、化学、药学、信息学和生物学领域具有良好预测潜力的桥网络的三种不同变体,因为K-Banhatti Sombor不变量是新提出的,并且对桥图或网络的不同变体具有许多预测质量。这些推导结果可用于计算机网络的建模,如局域网,城域网,广域网,互联网骨干和其他计算机网络/结构,发电,生物信息学和化学化合物。
{"title":"Analysis of Bridge Graph by Means of K-Banhatti Sombor Invariants","authors":"Abaid ur Rehman Virk, Saba Iram","doi":"10.32350/sir.64.01","DOIUrl":"https://doi.org/10.32350/sir.64.01","url":null,"abstract":"Any number that can be uniquely determined by a graph is called a graph invariant. During the last twenty years’ countless mathematical graph invariants have been characterized and utilized for correlation analysis. However, no reliable examination has been embraced to decide, how much these invariants are related with a network graph or molecular graph. In this paper, it will discuss three different variants of bridge networks with good potential of prediction in the field of computer science, mathematics, chemistry, pharmacy, informatics and biology in context with physical and chemical structures and networks, because K-Banhatti Sombor invariants are freshly presented and have numerous prediction qualities for different variants of bridge graphs or networks. These deduced results can be used for the modelling of computer networks like LAN, MAN, WAN, backbone of internet and other networks/structures of computers, power generation, bio-informatics and chemical compound.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126805328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial properties of binuclear Zn(II)-azomethine complexes derived from diaminodiphenylsulphide bridged spacer 二氨基二苯基硫化物桥接的双核Zn(II)-亚甲基配合物的抗菌性能
Pub Date : 2022-12-07 DOI: 10.32350/sir.64.04
Aziza Sarwar, Bibi Sherino, M. Ellahi, Nusrat Nabi, Bushra Naureen, Hamida Panezai
Antimicrobial resistance of microbes against treatment that once could  cure, has inspired an urgent need for new drugs development. Accordingly, three binuclear Zn(II)-Schiff bases complexes ZnLa - ZnLc were  prepared by direct reaction of the ligands La-Lc with Zn(II) ions in equimolar ratios bearing salicyldehydes with OH, NO2 and Cl functional groups. The synthesized compounds ZnLa - ZnLc were evaulated against Gram positive  (Enterococcus faecalis NCIMB 13280, Streptococcus mutant ATCC 25175™ and Staphylococcus aureus ATCC 6538™) and gram negative (Escheria coli NCTC 12900,  Salmonella typhi and Pseudomonas aeruginosa ATCC 15442) bacterial strains, respectively, by agar well diffusion and broth microdilution techniques. The minimum inhibitory concentration (MIC90) values were calculated by microplate reader at 550 nm to optimum result. It was found that  all the synthesized compounds showed promising antibacterial activity against the genus Streptococcus mutant followed Staphylococcus aureus and Escheria coli. Binuclear Zn(II) complexes had a superior antibacterial activity compared to their parent Schiff base ligands. In general, 3,4-dihydroxy derived Schiff bases  alongwith their relevant complexes exhibited magnificent antibacterial activity and hence merits to be established as promising keystone for subsequent antimicrobial drug advancement.
微生物对曾经可以治愈的治疗产生耐药性,激发了对新药开发的迫切需求。通过配体La-Lc与含有OH、NO2和Cl官能团的水杨醛的Zn(II)离子以等摩尔比直接反应,制备了三个双核Zn(II)- schiff碱配合物ZnLa - ZnLc。通过琼脂孔扩散和肉汤微量稀释技术,对合成的化合物ZnLa - ZnLc分别对革兰氏阳性(粪肠球菌NCIMB 13280、突变链球菌ATCC 25175™和金黄色葡萄球菌ATCC 6538™)和革兰氏阴性(大肠杆菌NCTC 12900、伤寒沙门氏菌和铜绿假单胞菌ATCC 15442)进行抑菌试验。在550 nm处用酶标仪计算最小抑菌浓度(MIC90)值,得到最佳结果。结果表明,所合成的化合物对突变链球菌、金黄色葡萄球菌和大肠杆菌均表现出良好的抑菌活性。双核Zn(II)配合物与其亲本席夫碱配体相比具有更强的抗菌活性。总的来说,3,4-二羟基希夫碱及其相关配合物具有良好的抗菌活性,因此有可能成为后续抗菌药物开发的重要基础。
{"title":"Antibacterial properties of binuclear Zn(II)-azomethine complexes derived from diaminodiphenylsulphide bridged spacer","authors":"Aziza Sarwar, Bibi Sherino, M. Ellahi, Nusrat Nabi, Bushra Naureen, Hamida Panezai","doi":"10.32350/sir.64.04","DOIUrl":"https://doi.org/10.32350/sir.64.04","url":null,"abstract":"Antimicrobial resistance of microbes against treatment that once could  cure, has inspired an urgent need for new drugs development. Accordingly, three binuclear Zn(II)-Schiff bases complexes ZnLa - ZnLc were  prepared by direct reaction of the ligands La-Lc with Zn(II) ions in equimolar ratios bearing salicyldehydes with OH, NO2 and Cl functional groups. The synthesized compounds ZnLa - ZnLc were evaulated against Gram positive  (Enterococcus faecalis NCIMB 13280, Streptococcus mutant ATCC 25175™ and Staphylococcus aureus ATCC 6538™) and gram negative (Escheria coli NCTC 12900,  Salmonella typhi and Pseudomonas aeruginosa ATCC 15442) bacterial strains, respectively, by agar well diffusion and broth microdilution techniques. The minimum inhibitory concentration (MIC90) values were calculated by microplate reader at 550 nm to optimum result. It was found that  all the synthesized compounds showed promising antibacterial activity against the genus Streptococcus mutant followed Staphylococcus aureus and Escheria coli. Binuclear Zn(II) complexes had a superior antibacterial activity compared to their parent Schiff base ligands. In general, 3,4-dihydroxy derived Schiff bases  alongwith their relevant complexes exhibited magnificent antibacterial activity and hence merits to be established as promising keystone for subsequent antimicrobial drug advancement.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126428620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Synthesis and applications of 1,2-diketones 1,2-二酮类化合物的合成及应用
Pub Date : 2022-12-07 DOI: 10.32350/sir.64.02
S. S. Gillani, I. Attique, Tanzeela Mehboob
This review outline different organic synthesis facilitated by 1,2-diketone and its various compounds. This review analyzes the published data on the synthesis of 1,2-diketone and its applications. 1,2-diketone intermediates play a vital role in the pharmaceutical field and are mostly used in the generation of medicine-related components. 1,2-diketone derivatives are also used as photosensitive agents and in material sciences as photoinitiators. In review, various synthesis and applications of 1,2-diketone focused.
本文综述了1,2-二酮及其化合物促进的各种有机合成。本文对1,2-二酮的合成及其应用进行了综述。1,2-二酮中间体在医药领域发挥着至关重要的作用,主要用于生成与药物相关的成分。1,2-二酮衍生物也用作光敏剂,在材料科学中用作光引发剂。综述了1,2-二酮的各种合成方法及其应用。
{"title":"Synthesis and applications of 1,2-diketones","authors":"S. S. Gillani, I. Attique, Tanzeela Mehboob","doi":"10.32350/sir.64.02","DOIUrl":"https://doi.org/10.32350/sir.64.02","url":null,"abstract":"This review outline different organic synthesis facilitated by 1,2-diketone and its various compounds. This review analyzes the published data on the synthesis of 1,2-diketone and its applications. 1,2-diketone intermediates play a vital role in the pharmaceutical field and are mostly used in the generation of medicine-related components. 1,2-diketone derivatives are also used as photosensitive agents and in material sciences as photoinitiators. In review, various synthesis and applications of 1,2-diketone focused.","PeriodicalId":137307,"journal":{"name":"Scientific Inquiry and Review","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114580971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Scientific Inquiry and Review
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1