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Sources and Chemistry of Flavonoids; their Biological and Therapeutic Potential 黄酮类化合物的来源及化学性质它们的生物学和治疗潜力
Pub Date : 2022-06-15 DOI: 10.32350/sir.62.03
Dr Shabbir Hussain, Waqar Mirza, Mufliha Murtaza, Ansa Nazir, I. Hanif, Muhammad Ahmad
Flavonoids are natural polyphenolic compounds, which are responsible for the taste and colors of medicinal plants, herbs, fruits, vegetables. Fruits (e.g., Berries, cherries, plums, apples, lemons, oranges, and grapes etc) and vegetables (e.g., broad beans, olives, onions, spinach, shallot etc) are the main sources of flavonoids. They also exist abundantly in cocoa products, black and green tea, red wine, red pepper, chamomile, celery, parsley, ginkgo, and mint. Flavonoids derivatives can also be synthesized through esterification, halogenation, alkoxylation, alkylation, aromatic hydroxylation, acylation and conjugation with various organic compounds. Flavonoids can be supplemented in a staple of food as nutraceutical agents and have an important role in human diet. They possess diverse biological activities including anti-inflammation, anti-oxidation, anti-cancer, anti-diabetes, anti-obesity, antimutagenic, neuroprotective and also have beneficial effects on oxidative stress, inflammation, insulin resistance, lipid metabolism and neurodegenerative diseases (e.g., amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease and Alzheimer’s disease). Flavonoids contain a 15-carbon skeleton; the basic structure consists of a flavan nucleus, a combination of two benzene and one pyran rings. Flavonoids are divided into eight important groups i.e., flavones, flavanols, isoflavones, flavan-3-ols, flavanonols, anthocyanidins, chalcones, and flavanones. A structure-activity relationship exists between flavonoids and their antioxidant activities. Flavonoids are effective in chelating metal ions and scavenging free radicals. The antioxidant properties of flavonoids are governed by their –OH groups, differences in hydrophobicity and molecular planarity.
类黄酮是一种天然的多酚类化合物,它负责药用植物、草药、水果和蔬菜的味道和颜色。水果(如浆果、樱桃、李子、苹果、柠檬、橙子和葡萄等)和蔬菜(如蚕豆、橄榄、洋葱、菠菜、葱等)是类黄酮的主要来源。它们也大量存在于可可制品、红茶和绿茶、红酒、红辣椒、洋甘菊、芹菜、欧芹、银杏和薄荷中。类黄酮衍生物还可以通过酯化、卤化、烷氧基化、烷基化、芳香羟基化、酰化和与各种有机化合物缀合而合成。黄酮类化合物可作为营养保健剂添加到主食中,在人类饮食中具有重要作用。它们具有多种生物活性,包括抗炎、抗氧化、抗癌、抗糖尿病、抗肥胖、抗诱变、神经保护,对氧化应激、炎症、胰岛素抵抗、脂质代谢和神经退行性疾病(如肌萎缩性侧索硬化症、亨廷顿氏病、帕金森病和阿尔茨海默病)也有有益作用。类黄酮含有15碳骨架;它的基本结构是一个黄烷核,由两个苯环和一个吡喃环组成。黄酮类化合物分为8大类,即黄酮类、黄烷醇类、异黄酮类、黄烷-3醇类、黄烷醇类、花青素类、查尔酮类和黄烷酮类。黄酮类化合物与其抗氧化活性之间存在构效关系。黄酮类化合物具有螯合金属离子和清除自由基的作用。黄酮类化合物的抗氧化性能取决于它们的-OH基团、疏水性和分子平面度的差异。
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引用次数: 1
Solution of Volterra integral equations of the 2nd kind with bulge function using Aboodh transform 用Aboodh变换求解第二类带凸函数的Volterra积分方程
Pub Date : 2022-06-10 DOI: 10.32350/sir.62.02
Asif Iqbal Ali, Muhammad Kalim, Adnan Khan
A large class of complexities in mathematical physics, applied mathematics, and engineering are expressed as differential equations with few additions and certain conditions. This research article studies the solution of Volterra integral equations of the second kind where bulge functions take as a known function. To obtain an analytical solution, this study uses the Aboodh transform, the Aboodh inverse transform and the convolution theorem whereas it would be required to discover the precise solution of VIEs. We will also compare it with a numerical solution using a modified Simpson method, and finally, we will represent it graphically.
数学物理、应用数学和工程中的一大类复杂问题都是用微分方程来表示的,只有很少的加法和一定的条件。本文研究了以凸函数为已知函数的第二类Volterra积分方程的解。为了得到解析解,本研究使用了Aboodh变换、Aboodh反变换和卷积定理,而这需要找到vie的精确解。我们还将使用改进的辛普森方法将其与数值解进行比较,最后,我们将用图形表示它。
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引用次数: 0
Double Moving Average Control Chart for Autocorrelated Data 自相关数据的双移动平均控制图
Pub Date : 2022-06-01 DOI: 10.32350/sir.62.01
Hira Arooj, K. Malik
The assumption of normality and independence is necessary for statistical inference of control charts. Misleading results are obtained if the traditional control chart technique is applied on the auto-correlated data. When data is correlated, a time series model is employed to produce an optimum output. The objective is to create a new control chart methodology that takes the autocorrelation of observations into account. Charts of Moving Average, Exponentially Weighted and Cumulative Sum better perform in the existence of autocorrelation data for small and moderate changes. The proposed methodology is highly skilled and receptive to minor, moderate and major changes in the process. Propsed DMA chart increases  efficiency of  average run length (ARL) chart for  moving average (MA) to detect the  small to medium magnitude shifts in the mean. The simulation also demonstrates that the DMA chart with spans of w=10 and 15 generally performs well in terms of average run length (ARL) as compared to clasical MA. This research may be extended to a multivariate autocorrelated statistical process control, but it can also be used to recognise and categorise seven categories of traditional control chart patterns, such as Downward, Upward Shift, Normal Trend, Cyclic, Systematic patterns, Increasing and Decresing Trend. In order to identify and categorize a set of subclasses of abnormal patterns, this model (multivariate autocorrelated statistical process control chart) should employ a multilayer feed forward Artificial Neural Network (ANN) architecture controlled by a back-propagation learning rule.
控制图的统计推断必须有正态性和独立性的假设。传统的控制图技术对自相关数据的处理容易产生错误的结果。当数据相关时,采用时间序列模型来产生最优输出。目标是创建一种新的控制图方法,将观测值的自相关性考虑在内。移动平均图、指数加权图和累积和图在存在自相关数据的情况下表现较好。拟议的方法是高度熟练的,可以接受过程中的轻微、中度和重大变化。提出的移动平均线图提高了移动平均线(MA)的平均运行长度(ARL)图的效率,以检测平均值的中小幅度移动。模拟还表明,与经典MA相比,跨度为w=10和15的DMA图表在平均运行长度(ARL)方面通常表现良好。本研究可扩展到多元自相关统计过程控制,但也可用于识别和分类7类传统控制图模式,如向下、向上移位、正常趋势、循环、系统模式、增加和减少趋势。为了对异常模式的一组子类进行识别和分类,该模型(多元自相关统计过程控制图)应采用由反向传播学习规则控制的多层前馈人工神经网络(ANN)体系结构。
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引用次数: 1
Statistically Convergent Sequences in Neutrosophic Metric Spaces 中性度量空间中的统计收敛序列
Pub Date : 2022-03-30 DOI: 10.32350/sir.61.03
Usman Ali, Umar Ishtiaq, Khaleel Ahmad, Jahanzaib
In this study, the introduction of statistical convergence and statistical Cauchy sequences with respect to neutrosophic metric spaces is motivated by the notion of statistical convergence in fuzzy metric spaces. We offer useful characterizations for statistically convergent and statistically Cauchy sequences.
在本研究中,中性度量空间的统计收敛和统计柯西序列的引入是由模糊度量空间中的统计收敛的概念所激发的。我们给出了统计收敛和统计柯西序列的有用刻画。
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引用次数: 1
General Construction of Efficient Circular Weakly Balanced Repeated Measurements Designs 有效圆形弱平衡重复测量设计的一般构造
Pub Date : 2022-03-30 DOI: 10.32350/sir.61.05
Q. Mehmood, Kashif Rasheed, Khadija Noreen, Rashid Ahmed, Berihan R. Elemary
Weakly balanced repeated measurements designs (RMDs) are used to balance out residual effects where minimal balanced RMDs cannot be obtained. RMDs are equally important in periods of both equal and unequal sizes. There should be a general procedure to construct these designs. In this article, some generators are developed for the general construction of efficient minimal circular weakly balanced RMDs.
弱平衡重复测量设计(rmd)用于在无法获得最小平衡rmd的情况下平衡残余效应。rmd在大小相等和不相等的时期都同样重要。应该有一个通用的程序来构建这些设计。本文开发了一些发电机,用于构造有效的最小圆弱平衡rmd。
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引用次数: 0
Operational Matrix of Fractional Order Integration and Its Application to Solve Fractional Differential Equations (FDEs) Using Haar Wavelet Collocation Method (HWCM) 分数阶积分的运算矩阵及其在Haar小波配置法求解分数阶微分方程中的应用
Pub Date : 2022-03-30 DOI: 10.32350/sir.61.04
A. Deshi, G. A. Gudodagi
Wavelets play an essential part in numerical analysis. In this study, a novel numerical technique to solve fractional differential equations (FDEs) corresponding to initial conditions is presented using Haar wavelet approximations. Haar wavelet is first presented with an operational matrix of fractional order integration. Then, illustrative examples are presented to signify the validity and applicability of the proposed method.  
小波在数值分析中起着重要的作用。本文提出了一种利用Haar小波近似求解初值条件下分数阶微分方程的新方法。首先用分数阶积分的运算矩阵来描述哈尔小波。最后通过算例验证了所提方法的有效性和适用性。
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引用次数: 0
Implementation of Lengyel-Epstein Reaction Model for Zinc Oxide (ZnO) Nanostructures by Comparing Euler and Fourth-Order Runge–Kutta (RK) Methods 用欧拉和四阶龙格-库塔(RK)方法比较氧化锌纳米结构的lengye - epstein反应模型
Pub Date : 2022-03-30 DOI: 10.32350/sir.61.02
Kaniz Fatima, Basit Ali, Mahnoor
The current study presents Lengyel-Epstein reaction model for the analysis of the reaction kinematics of the growth of Zinc oxide (ZnO) nanostructures using the fourth-order Runge-Kutta (RK) method. The aim is to propose an improved approximation technique for the computation of the concentrations of Zinc ion and Hydroxyl ion. For this purpose, a comparison of Euler's method with the fourth-order RK method was made to gauge their effectiveness in determining the concentrations of both ions. It was determined that the fourth-order RK method gives more stable results than Euler’s method. In this regard, the comparison with Euler's method showed that the rate of convergence of the RK method is more appropriate than Euler's method. Furthermore, it was also determined that the RK method validates the experimental results for the formation of ZnO nanostructures using the aqueous chemical growth (ACG) method.
本研究采用四阶龙格-库塔(RK)方法建立了用于氧化锌纳米结构生长反应运动学分析的lengyell - epstein反应模型。目的是提出一种改进的计算锌离子和羟基离子浓度的近似技术。为此,欧拉法与四阶RK法进行了比较,以衡量它们在确定两种离子浓度方面的有效性。结果表明,四阶RK法比欧拉法得到的结果更稳定。在这方面,与欧拉方法的比较表明,RK方法的收敛速度比欧拉方法更合适。此外,RK方法验证了水化学生长(ACG)方法形成ZnO纳米结构的实验结果。
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引用次数: 0
Application of Univariate Probability Distributions Fitting With Monte Carlo Simulation 蒙特卡罗模拟在单变量概率分布拟合中的应用
Pub Date : 2022-01-13 DOI: 10.32350/sir.54.02
Muhammad Ilyas, Shaheen Abbas, Afzal Ali
In this study, we present a univariate probability distribution through application of the three Sub and Super Exponential heavier-longer and lighter-shorter tails fitting. This univariate family includes the Lognormal, Gamma and Weibull distribution, the adequacy of the distribution tails is obtained by adequate Fitting Tests and descriptive Criterion. It emphasizes on tail values and is independent of the number of intervals. In this regards the time series analysis for the last three centuries of the logarithm population data sets over to Karachi region (from1729 to1946 and from 1951 to 2018) is used, which contains irregular and regular length and peaks, That peaks /tails fitting is attained by methods for validation and normality tests and defined by stochastic depiction. In other hand, Weibull and Lognormal distribution tails are found as heavier distribution by two validation tests (Maximum Likelihood Estimation and probability of correct selection), In the final section, the univariate probability distributions are used to Monte Carlo simulation for generating the actual population data, it indicates that the heavy-tailed Lognormal and Weibull distributions are also fitted contract than the more commonly seen lighter tailed Gamma distribution. So, the Monte Carlo Simulation performs the appropriate Lognormal and Weibull distributions for irregular and regular data and generate data values (298 and 69) from duration of 1729 to 2020 and 1951 to 2020. Copyright(c) The Author
在本研究中,我们通过应用三个亚指数和超指数的重-长和轻-短尾拟合,给出了一个单变量概率分布。这个单变量族包括对数正态分布、伽玛分布和威布尔分布,分布尾部的充分性是通过适当的拟合检验和描述性标准获得的。它强调尾部值,与区间的数量无关。在这方面,使用了卡拉奇地区(从1729年到1946年和从1951年到2018年)对数人口数据集的过去三个世纪的时间序列分析,其中包含不规则和规则的长度和峰,峰/尾拟合是通过验证和正态性检验方法获得的,并由随机描述定义。另一方面,威布尔分布和对数正态分布的尾部通过两个验证测试(极大似然估计和正确选择概率)被发现是较重的分布,在最后一节中,单变量概率分布被用于蒙特卡罗模拟来生成实际的总体数据,这表明重尾对数正态分布和威布尔分布也比更常见的轻尾伽马分布拟合得更紧密。因此,蒙特卡罗模拟对不规则和规则数据执行适当的对数正态分布和威布尔分布,并生成1729至2020年和1951至2020年期间的数据值(298和69)。版权(c)作者
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引用次数: 0
Green Synthesis of Trimetallic Oxides of Mn, Cu, Zn Using Rose Petals and their Antimicrobial Activity 玫瑰花瓣绿色合成锰、铜、锌三金属氧化物及其抑菌活性
Pub Date : 2021-12-30 DOI: 10.32350/sir.54.05
S. S. Gillani, S. Khan, R. Nazir, A. Qurashi
Mixed metal oxides (CuO, ZnO, and MnO) nanoparticles (NPs) were synthesized by the green process which is simple, cost-effective, eco-friendly, and non-toxic. In the green synthesis method, rose petals extracts were used as a reducing and capping agent while salt solutions (CuCl2, MnCl2, and ZnSO4) were used as a precursor that lead to the formation of mixed metal oxides (CuO, ZnO, MnO) NPs. UV-Visible and FTIR spectroscopy were used for the analysis of mixed metal oxides (CuO, ZnO, MnO) NPs, which showed maximum absorbance in the range of 280 to 370 nm. The presence of particular peaks in FTIR verified the synthesis of mixed metal oxide nanoparticles. The antimicrobial and antifungal activities of mixed metal oxides (CuO, ZnO, MnO) NPs were carried out by the disc diffusion method and well diffusion method. Mixed metal oxides (CuO, ZnO, MnO) NPs showed antimicrobial activity against Escherichia coli and antifungal activity against Candida albicans, Curvularia lunata, Aspergillus niger, and Trichophyton simii. So, these mixed metal oxides (CuO, ZnO, MnO) NPs can be effective in the pharmaceutical sector. Keywords: antifungal, antimicrobial, green synthesis, mixed metal oxides nanoparticles (MONPs), rose petals extracts Copyright (c) The Authors
采用简单、经济、环保、无毒的绿色工艺合成了CuO、ZnO和MnO混合金属氧化物纳米颗粒。在绿色合成方法中,以玫瑰花瓣提取物作为还原和封盖剂,以盐溶液(CuCl2, MnCl2和ZnSO4)作为前驱体,形成混合金属氧化物(CuO, ZnO, MnO) NPs。利用紫外可见光谱和红外光谱对混合金属氧化物(CuO, ZnO, MnO) NPs进行了分析,其最大吸光度在280 ~ 370 nm范围内。红外光谱中出现的特殊峰证实了混合金属氧化物纳米颗粒的合成。采用圆盘扩散法和孔扩散法研究了混合金属氧化物(CuO、ZnO、MnO) NPs的抑菌活性。混合金属氧化物(CuO、ZnO、MnO) NPs对大肠杆菌、白色念珠菌、月曲菌、黑曲霉和相似毛癣菌均有抑菌活性。因此,这些混合金属氧化物(CuO, ZnO, MnO) NPs可以有效地用于制药领域。关键词:抗真菌,抗菌,绿色合成,混合金属氧化物纳米颗粒(MONPs),玫瑰花瓣提取物
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引用次数: 0
Numerical Solution with Non-Polynomial Cubic Spline Technique of Order Four Homogeneous Parabolic Partial Differential Equations 四阶齐次抛物型偏微分方程的非多项式三次样条法数值解
Pub Date : 2021-12-27 DOI: 10.32350/sir.54.03
Bilal Ahmad, Anjum Perviz, M. O. Ahmad, F. Dayan
An innovative technique of NPCS are being used in engineering, computer sciences and natural sciences field to solve PDEs and ODEs Problems. There are many problems not having exact solution or not much stable and convergent exact solution, to solve such problem one apply different approximation, iterative and many other methods. The developed technique is one of them and implemented on some homogeneous parabolic PDEs of different dimensions and getting results will compare with exact solution and one other existing method, by tabular and graphically as well. Graphs and Mathematical result are found by using MATHEMATICA. Copyright(c) The Authors
在工程、计算机科学和自然科学领域,一种用于解决偏微分方程和偏微分方程问题的创新技术被广泛应用。有许多问题没有精确解或稳定收敛的精确解不多,为了解决这类问题,可以采用不同的近似、迭代等方法。本文所提出的方法就是其中的一种,并将其应用于不同维数的齐次抛物型偏微分方程,所得结果将与精确解和另一种现有方法进行表格和图形的比较。利用MATHEMATICA软件进行了图形和数学计算。版权(c)作者
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引用次数: 2
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