Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146559
Chi-Hsu Wu, H. Lakany
Steady-state visual evoked potential (SSVEP) based brain-computer interface (BCI) has attracted great attention in BCI research due to its advantages over the other electroencephalography (EEG) based BCI paradigms, such as high speed, high signal to noise ratio, high accuracy, commands scalability and minimal user training time. Several studies have demonstrated that SSVEP BCI can provide a reliable channel to the users to communicate and control an external device. While most SSVEP based BCI studies focus on encoding the visual stimuli, enhancing the signal detection and improving the classification accuracy, there is a need to bridge the gap between BCI “bench” research and real world application. This study proposes a novel distance adaptable SSVEP based BCI paradigm which allows its users to operate the system in a range of viewing distances between the user and the visual stimulator. Unlike conventional SSVEP BCI where users can only operate the system at a fixed distance in front of the visual stimulator, users can operate the proposed BCI at a range of viewing distances. 10 healthy subjects participated in the experiment to evaluate the feasibility of the proposed SSVEP BCI. The visual stimulator was presented to the subjects at 4 viewing distances, 60cm, 150cm, 250cm and 350cm. The mean classification accuracy across the subjects and the viewing distances is over 75%. The results demonstrate the feasibility of a distance adaptable SSVEP based BCI.
{"title":"Evaluation of the feasibility of a novel distance adaptable steady-state visual evoked potential based brain-computer interface","authors":"Chi-Hsu Wu, H. Lakany","doi":"10.1109/NER.2015.7146559","DOIUrl":"https://doi.org/10.1109/NER.2015.7146559","url":null,"abstract":"Steady-state visual evoked potential (SSVEP) based brain-computer interface (BCI) has attracted great attention in BCI research due to its advantages over the other electroencephalography (EEG) based BCI paradigms, such as high speed, high signal to noise ratio, high accuracy, commands scalability and minimal user training time. Several studies have demonstrated that SSVEP BCI can provide a reliable channel to the users to communicate and control an external device. While most SSVEP based BCI studies focus on encoding the visual stimuli, enhancing the signal detection and improving the classification accuracy, there is a need to bridge the gap between BCI “bench” research and real world application. This study proposes a novel distance adaptable SSVEP based BCI paradigm which allows its users to operate the system in a range of viewing distances between the user and the visual stimulator. Unlike conventional SSVEP BCI where users can only operate the system at a fixed distance in front of the visual stimulator, users can operate the proposed BCI at a range of viewing distances. 10 healthy subjects participated in the experiment to evaluate the feasibility of the proposed SSVEP BCI. The visual stimulator was presented to the subjects at 4 viewing distances, 60cm, 150cm, 250cm and 350cm. The mean classification accuracy across the subjects and the viewing distances is over 75%. The results demonstrate the feasibility of a distance adaptable SSVEP based BCI.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127894160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146619
Jean-Marie C. Bouteiller, Zhuobo Feng, A. Onopa, Mike Huang, Eric Y. Hu, Endre T. Somogyi, M. Baudry, Serge Bischoff, T. Berger
Computational models are mathematical representations meant to replicate the biological system they represent, as well as provide insights and predict the system's dynamics in response to changing conditions. In a bottom-up modeling approach, a multitude of models may be compounded to represent more complex higher level biological systems. However, guaranteeing the validity and predictability of the compounded ensemble may become increasingly challenging as more components are integrated. We herein present a sequential and iterative method to maximize predictability of a complex multiscale model. We have successfully developed a multiscale modeling platform comprised of mechanisms ranging from the biomolecular level to multi-cellular networks. To maintain a high level of predictability of the global platform, we introduce a systematic approach to not only validate all models independently, but also verify the validity of compounded models as additional information becomes available at higher levels of complexity. Iterative and systematic application of these validation steps at increasing levels of complexity is intended to maximize the predictive power of the platform, making it a powerful tool to study the impacts of low-levels modifications (pathologies, drugs, etc.) on higher functional levels. The work presented lays down the rationale of the approach, the open design implementation and results.
{"title":"Maximizing predictability of a bottom-up complex multi-scale model through systematic validation and multi-objective multi-level optimization","authors":"Jean-Marie C. Bouteiller, Zhuobo Feng, A. Onopa, Mike Huang, Eric Y. Hu, Endre T. Somogyi, M. Baudry, Serge Bischoff, T. Berger","doi":"10.1109/NER.2015.7146619","DOIUrl":"https://doi.org/10.1109/NER.2015.7146619","url":null,"abstract":"Computational models are mathematical representations meant to replicate the biological system they represent, as well as provide insights and predict the system's dynamics in response to changing conditions. In a bottom-up modeling approach, a multitude of models may be compounded to represent more complex higher level biological systems. However, guaranteeing the validity and predictability of the compounded ensemble may become increasingly challenging as more components are integrated. We herein present a sequential and iterative method to maximize predictability of a complex multiscale model. We have successfully developed a multiscale modeling platform comprised of mechanisms ranging from the biomolecular level to multi-cellular networks. To maintain a high level of predictability of the global platform, we introduce a systematic approach to not only validate all models independently, but also verify the validity of compounded models as additional information becomes available at higher levels of complexity. Iterative and systematic application of these validation steps at increasing levels of complexity is intended to maximize the predictive power of the platform, making it a powerful tool to study the impacts of low-levels modifications (pathologies, drugs, etc.) on higher functional levels. The work presented lays down the rationale of the approach, the open design implementation and results.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127750462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146567
Lin Yao, Tao Xie, Xiaokang Shu, X. Sheng, Dingguo Zhang, Xiangyang Zhu
In this work, paired sensory stimulation training via pavlovian conditioning (PSSPC) was proposed to improve motor imagery BCI performance, especially targeted in those poor performing BCI users. Motor imagery task was paired with the sensory stimulus to establish the conditioned responses through the long-term classic conditioning training. Three poor performing subjects were recruited to participate the PSSPC experiment lasting for about one month in eight sessions. R2 contrast image have shown that the discriminative brain pattern was emerged out in the sensorimotor area of the brain after several sessions training. In addition, up to 80% BCI performance was achieve to some subjects, and it has also shown that learning was evolved in the PSSPC training, complementary to the feedback based training (also termed operant conditioning). The PSSPC methodology has the potential in improving those poor performing BCI subjects, and laid the potential to guide the cortical plastic changes for those with motor impairments.
{"title":"Long-term paired sensory stimulation training for improved motor imagery BCI performance via pavlovian conditioning theory","authors":"Lin Yao, Tao Xie, Xiaokang Shu, X. Sheng, Dingguo Zhang, Xiangyang Zhu","doi":"10.1109/NER.2015.7146567","DOIUrl":"https://doi.org/10.1109/NER.2015.7146567","url":null,"abstract":"In this work, paired sensory stimulation training via pavlovian conditioning (PSSPC) was proposed to improve motor imagery BCI performance, especially targeted in those poor performing BCI users. Motor imagery task was paired with the sensory stimulus to establish the conditioned responses through the long-term classic conditioning training. Three poor performing subjects were recruited to participate the PSSPC experiment lasting for about one month in eight sessions. R2 contrast image have shown that the discriminative brain pattern was emerged out in the sensorimotor area of the brain after several sessions training. In addition, up to 80% BCI performance was achieve to some subjects, and it has also shown that learning was evolved in the PSSPC training, complementary to the feedback based training (also termed operant conditioning). The PSSPC methodology has the potential in improving those poor performing BCI subjects, and laid the potential to guide the cortical plastic changes for those with motor impairments.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"64 2-3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126972404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146660
F. Bottausci, F. Baleras, Catherine Pudda, M. Cochet, Claude Chabrol, F. Sauter-Starace, Julie Oziat, Maelys Rovetta, B. Icard, D. Guiraud, J. Divoux, C. Malbert, C. Henry, S. Maubert
This paper describes the fabrication and the packaging of a flexible parylene-based multi-contact electrode embedded in a silicone-based cuff. This type of electrode is well suited for peripheral nerve recording and offers improved spatial selectivity. We conducted mechanical and electrical tests for assessing the reliability by using an accelerated lifetime protocol. Test structures made with platinum sandwiched with parylene C were designed. The accelerated lifetime soaking tests in phosphate buffered saline (PBS) solution at 67°C showed a longer life time (approximatively 4.5 years) with a dehydration bake introduction in the process flow and a parylene thickness increase. A specific test bench was developed for the mechanical cycling and for evaluating the mechanical robustness of the thin film devices.
{"title":"New sectorized implantable microelectrode fabrication, packaging and ageing for neural sensing and stimulation","authors":"F. Bottausci, F. Baleras, Catherine Pudda, M. Cochet, Claude Chabrol, F. Sauter-Starace, Julie Oziat, Maelys Rovetta, B. Icard, D. Guiraud, J. Divoux, C. Malbert, C. Henry, S. Maubert","doi":"10.1109/NER.2015.7146660","DOIUrl":"https://doi.org/10.1109/NER.2015.7146660","url":null,"abstract":"This paper describes the fabrication and the packaging of a flexible parylene-based multi-contact electrode embedded in a silicone-based cuff. This type of electrode is well suited for peripheral nerve recording and offers improved spatial selectivity. We conducted mechanical and electrical tests for assessing the reliability by using an accelerated lifetime protocol. Test structures made with platinum sandwiched with parylene C were designed. The accelerated lifetime soaking tests in phosphate buffered saline (PBS) solution at 67°C showed a longer life time (approximatively 4.5 years) with a dehydration bake introduction in the process flow and a parylene thickness increase. A specific test bench was developed for the mechanical cycling and for evaluating the mechanical robustness of the thin film devices.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"20 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130982502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146747
Meredith J. Cler, Graham E. Voysey, C. Stepp
Poor control over the velopharyngeal (VP) port (connection between the oral and nasal cavities) leads to unintelligible speech; this VP dysfunction (VPD) can be due to structural abnormalities, poor motor control, or lack of appropriate feedback (hearing impairment). VP control is not aided by visual feedback since the relevant anatomy is not visible to the speaker or the listener. Here we present initial data from a novel, game-based speech rehabilitation platform designed for children with VPD, in which online feedback of speech nasalization is provided based on measurements of nasal skin vibration and speech acoustics. Twelve pediatric participants (three with VPD) completed one session with the video game and were all able to easily use the game. Over 90% of the participants reported that the game was at least “kind of fun” and that the equipment at least “kind of comfortable”. Over 90% of participants and 100% of their parents said they could use the game at home. Results are promising for further development and long-term testing in individuals with VPD.
{"title":"Video game speech rehabilitation for velopharyngeal dysfunction: Feasibility and pilot testing","authors":"Meredith J. Cler, Graham E. Voysey, C. Stepp","doi":"10.1109/NER.2015.7146747","DOIUrl":"https://doi.org/10.1109/NER.2015.7146747","url":null,"abstract":"Poor control over the velopharyngeal (VP) port (connection between the oral and nasal cavities) leads to unintelligible speech; this VP dysfunction (VPD) can be due to structural abnormalities, poor motor control, or lack of appropriate feedback (hearing impairment). VP control is not aided by visual feedback since the relevant anatomy is not visible to the speaker or the listener. Here we present initial data from a novel, game-based speech rehabilitation platform designed for children with VPD, in which online feedback of speech nasalization is provided based on measurements of nasal skin vibration and speech acoustics. Twelve pediatric participants (three with VPD) completed one session with the video game and were all able to easily use the game. Over 90% of the participants reported that the game was at least “kind of fun” and that the equipment at least “kind of comfortable”. Over 90% of participants and 100% of their parents said they could use the game at home. Results are promising for further development and long-term testing in individuals with VPD.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131622993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146706
R. Jegadeesan, N. Thakor, S. Yen
Plethora of implant devices reported in the last decade are enabled using wireless power delivery and telemetry systems. In this work, we present the design of wireless a platform that enables a completely implantable peripheral nerve prosthesis. Large power (over 100mW) delivery and large bandwidth telemetry (1.3 Mbps) demanded by this prosthesis application are addressed by the proposed platform whilst still adhering to the regulatory specific absorption rate safety limits (2W/Kg). The wireless platform is built and verified using acute rodent experiments.
{"title":"Wireless for peripheral nerve prosthesis and safety","authors":"R. Jegadeesan, N. Thakor, S. Yen","doi":"10.1109/NER.2015.7146706","DOIUrl":"https://doi.org/10.1109/NER.2015.7146706","url":null,"abstract":"Plethora of implant devices reported in the last decade are enabled using wireless power delivery and telemetry systems. In this work, we present the design of wireless a platform that enables a completely implantable peripheral nerve prosthesis. Large power (over 100mW) delivery and large bandwidth telemetry (1.3 Mbps) demanded by this prosthesis application are addressed by the proposed platform whilst still adhering to the regulatory specific absorption rate safety limits (2W/Kg). The wireless platform is built and verified using acute rodent experiments.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"599 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131641987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146707
Tamas Kapelner, N. Jiang, I. Vujaklija, O. Aszmann, A. Holobar, D. Farina
For the past six decades, signal processing methods for myoelectric control of prostheses consisted mainly of calculating time- and frequency domain features of the EMG signal. This type of feature extraction considers the surface EMG as colored noise, neglecting its generation as a sum of motor unit activities. In this study we propose the use of motor unit behavior for classifying motor tasks with the aim of myoelectric control. We recorded high-density surface EMG of three patients who underwent targeted muscle reinnervation, and decomposed these signals into motor unit spike trains using an automatic offline EMG decomposition method. From the motor unit spike trains we used the number of discharges in each analysis interval as a feature for a support vector machine classifier. The same classifier was used for discriminating classic time-domain EMG features, for comparison. Classification accuracy was greater for motor unit information than for the classic features (97.06%±1.74 vs 85.01%±13.66), especially when the number of classes was high (95.11% ± 1.74 vs 69.25% ± 4.04 for 11 classes). These results suggest that the identification of motor unit activity from surface EMG can be a powerful way for pattern recognition in targeted muscle reinnervation patients.
过去六十年来，假肢肌电控制的信号处理方法主要包括计算肌电信号的时域和频域特征。这种特征提取方法将表面肌电信号视为彩色噪声，忽略了其作为运动单元活动总和的产生。在本研究中，我们提出利用运动单元行为对运动任务进行分类，以达到肌电控制的目的。我们记录了三名接受靶向肌肉神经支配的患者的高密度表面肌电图，并使用自动离线肌电图分解方法将这些信号分解为运动单元尖峰列车。从运动单元尖峰列车中，我们使用每个分析区间的放电次数作为支持向量机分类器的特征。为了进行比较，我们使用了相同的分类器来区分经典的时域肌电图特征。与经典特征相比，运动单位信息的分类准确率更高（97.06%±1.74 vs 85.01%±13.66），尤其是当类别数量较多时（11 个类别的分类准确率为 95.11%±1.74 vs 69.25%±4.04 ）。这些结果表明，从表面肌电图中识别运动单位活动是对目标肌肉神经再支配患者进行模式识别的有效方法。
{"title":"Classification of motor unit activity following targeted muscle reinnervation","authors":"Tamas Kapelner, N. Jiang, I. Vujaklija, O. Aszmann, A. Holobar, D. Farina","doi":"10.1109/NER.2015.7146707","DOIUrl":"https://doi.org/10.1109/NER.2015.7146707","url":null,"abstract":"For the past six decades, signal processing methods for myoelectric control of prostheses consisted mainly of calculating time- and frequency domain features of the EMG signal. This type of feature extraction considers the surface EMG as colored noise, neglecting its generation as a sum of motor unit activities. In this study we propose the use of motor unit behavior for classifying motor tasks with the aim of myoelectric control. We recorded high-density surface EMG of three patients who underwent targeted muscle reinnervation, and decomposed these signals into motor unit spike trains using an automatic offline EMG decomposition method. From the motor unit spike trains we used the number of discharges in each analysis interval as a feature for a support vector machine classifier. The same classifier was used for discriminating classic time-domain EMG features, for comparison. Classification accuracy was greater for motor unit information than for the classic features (97.06%±1.74 vs 85.01%±13.66), especially when the number of classes was high (95.11% ± 1.74 vs 69.25% ± 4.04 for 11 classes). These results suggest that the identification of motor unit activity from surface EMG can be a powerful way for pattern recognition in targeted muscle reinnervation patients.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134211622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146754
Allison T. Connolly, W. Kaemmerer, Siddharth Dani, S. Stanslaski, E. Panken, Matthew D. Johnson, T. Denison
We have found that a set of support vector machines operating upon local field potentials sensed from an implanted DBS lead can identify the contact chosen by the physician for the patient's STN DBS therapy with 91% accuracy. The finding is based on a small data set and thus subject to change with further data collection and cross-validation. Nevertheless, the results suggest that an algorithm for selecting an effective contact for STN DBS based on the signals sensed from the DBS lead may be feasible.
{"title":"Guiding deep brain stimulation contact selection using local field potentials sensed by a chronically implanted device in Parkinson's disease patients","authors":"Allison T. Connolly, W. Kaemmerer, Siddharth Dani, S. Stanslaski, E. Panken, Matthew D. Johnson, T. Denison","doi":"10.1109/NER.2015.7146754","DOIUrl":"https://doi.org/10.1109/NER.2015.7146754","url":null,"abstract":"We have found that a set of support vector machines operating upon local field potentials sensed from an implanted DBS lead can identify the contact chosen by the physician for the patient's STN DBS therapy with 91% accuracy. The finding is based on a small data set and thus subject to change with further data collection and cross-validation. Nevertheless, the results suggest that an algorithm for selecting an effective contact for STN DBS based on the signals sensed from the DBS lead may be feasible.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133243735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146610
F. Lane, Kristian B. Nitsch, P. Troyk
A total of thirteen individuals were interviewed and asked to describe their experiences of participating in a cortical vision implant study conducted by William Dobelle between 2000 and 2005. The transcripts from the interviews were analyzed using MAXQDA software and themes that resulted from the interviews such as motivation to participate, sensory substitution expectations, decision-making process, experience of artificial vision and functional use of artificial vision is described in depth. Emotional experiences of participating in the study result in ethical and psychological implications for future research.
{"title":"Participant perspectives from a cortical vision implant study: Ethical and psychological implications","authors":"F. Lane, Kristian B. Nitsch, P. Troyk","doi":"10.1109/NER.2015.7146610","DOIUrl":"https://doi.org/10.1109/NER.2015.7146610","url":null,"abstract":"A total of thirteen individuals were interviewed and asked to describe their experiences of participating in a cortical vision implant study conducted by William Dobelle between 2000 and 2005. The transcripts from the interviews were analyzed using MAXQDA software and themes that resulted from the interviews such as motivation to participate, sensory substitution expectations, decision-making process, experience of artificial vision and functional use of artificial vision is described in depth. Emotional experiences of participating in the study result in ethical and psychological implications for future research.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131933064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-22DOI: 10.1109/NER.2015.7146677
M. Bisio, Valentina Pasquale, A. Bosca, L. Berdondini, M. Chiappalone
The development of in vitro neuronal models constituted by patterned networks is of significant interest in the neuroscientific community and requires the convergence of electrophysiological studies with micro/nano-fabrication techniques. In this paper we make use of a methodology to induce self-organization of networks into two connected sub-populations grown onto commercially available Micro Electrode Arrays (MEAs) in order to understand the role of `burst leaders' in generating the collective synchronous events (i.e. network bursts) spontaneously arising in dissociated cultures. Considering the multitude of connections shown by uniform neuronal cultures, the restraint of neurite outgrowth along specific pathways ensures a considerable control over network complexity. Here we exploit this topological configuration to investigate whether and how network burst generation is affected by the development of the network. Our results constitute important evidence that engineered neuronal networks are a powerful platform to systematically approach questions related to the dynamics of neuronal assemblies.
{"title":"Role of major burst leaders in modular hippocampal networks","authors":"M. Bisio, Valentina Pasquale, A. Bosca, L. Berdondini, M. Chiappalone","doi":"10.1109/NER.2015.7146677","DOIUrl":"https://doi.org/10.1109/NER.2015.7146677","url":null,"abstract":"The development of in vitro neuronal models constituted by patterned networks is of significant interest in the neuroscientific community and requires the convergence of electrophysiological studies with micro/nano-fabrication techniques. In this paper we make use of a methodology to induce self-organization of networks into two connected sub-populations grown onto commercially available Micro Electrode Arrays (MEAs) in order to understand the role of `burst leaders' in generating the collective synchronous events (i.e. network bursts) spontaneously arising in dissociated cultures. Considering the multitude of connections shown by uniform neuronal cultures, the restraint of neurite outgrowth along specific pathways ensures a considerable control over network complexity. Here we exploit this topological configuration to investigate whether and how network burst generation is affected by the development of the network. Our results constitute important evidence that engineered neuronal networks are a powerful platform to systematically approach questions related to the dynamics of neuronal assemblies.","PeriodicalId":137451,"journal":{"name":"2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124045918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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