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2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)最新文献

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Hybrid Brain Computer Interface via Bayesian integration of EEG and eye gaze 基于脑电和眼球注视贝叶斯融合的混合脑机接口
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146582
Xujiong Dong, Haofei Wang, Zhaokang Chen, Bertram E. Shi
We describe a hybrid brain computer interface that integrates information from a four-class motor imagery based EEG classifier with information about gaze trajectories from an eye tracker. The novel aspect of this system is that no explicit gaze behavior is required of the user. Rather, the natural gaze behavior of the user integrated probabilistically to smooth the noisy classification results from the motor imagery based EEG. The goal is to provide for a more natural interaction with the BCI system than if gaze were used as an explicit command signal, as is commonly done. Our results on a 2D cursor control task show that integration of gaze information significantly improves task completion accuracy and reduces task completion time. In particular, our system achieves over 80% target completion accuracy on a cursor control task requiring guidance to one of 12 targets.
我们描述了一个混合脑机接口,该接口集成了来自基于四类运动图像的EEG分类器的信息和来自眼动仪的凝视轨迹信息。该系统的新颖之处在于不需要用户进行明确的凝视行为。相反,用户的自然凝视行为进行概率整合,以平滑基于运动图像的EEG的噪声分类结果。目标是提供与BCI系统更自然的交互,而不是像通常那样将凝视用作明确的命令信号。我们在一个2D光标控制任务上的研究结果表明,注视信息的整合显著提高了任务完成的准确性,缩短了任务完成的时间。特别是,我们的系统在需要引导到12个目标中的一个的光标控制任务上实现了超过80%的目标完成精度。
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引用次数: 20
Inherently stochastic spiking neurons for probabilistic neural computation 用于概率神经计算的固有随机尖峰神经元
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146633
Maruan Al-Shedivat, R. Naous, E. Neftci, G. Cauwenberghs, K. Salama
Neuromorphic engineering aims to design hardware that efficiently mimics neural circuitry and provides the means for emulating and studying neural systems. In this paper, we propose a new memristor-based neuron circuit that uniquely complements the scope of neuron implementations and follows the stochastic spike response model (SRM), which plays a cornerstone role in spike-based probabilistic algorithms. We demonstrate that the switching of the memristor is akin to the stochastic firing of the SRM. Our analysis and simulations show that the proposed neuron circuit satisfies a neural computability condition that enables probabilistic neural sampling and spike-based Bayesian learning and inference. Our findings constitute an important step towards memristive, scalable and efficient stochastic neuromorphic platforms.
神经形态工程旨在设计能够有效模拟神经回路的硬件,为模拟和研究神经系统提供手段。在本文中,我们提出了一种新的基于记忆电阻的神经元电路,它独特地补充了神经元实现的范围,并遵循随机尖峰响应模型(SRM),该模型在基于尖峰的概率算法中起着基石作用。我们证明了忆阻器的开关类似于SRM的随机发射。我们的分析和模拟表明,所提出的神经元电路满足神经可计算性条件,使概率神经采样和基于峰值的贝叶斯学习和推理成为可能。我们的发现是迈向记忆、可扩展和高效的随机神经形态平台的重要一步。
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引用次数: 22
Web-enabled software for clinical telegaming evaluation of multisensory integration and response to auditory and visual stimuli 用于临床远程游戏评估多感觉整合和对听觉和视觉刺激的反应的网络软件
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146729
Linda Xu, S. Loh, C. Taswell
Clinical telegaming integrates telecare and videogaming to enable a more convenient and enjoyable experience for patients when providers diagnose, monitor, and treat a variety of health problems via web-enabled telecommunications. In recent years, clinical telegaming systems have been applied to physical therapy and rehabilitation, evaluation of mental health, and prevention and management of obesity and diabetes. Parkinson's disease (PD) is suitable for development of new clinical telegaming applications because PD patients are known to experience motor symptoms that can be improved by physical therapy. Recent research suggests that sensory processing deficits may also play an important role in these motor impairments because successful motor function requires multisensory integration. In this paper, we describe a new web-enabled software system that uses clinical telegaming to evaluate and improve multisensory integration ability in users. This software has the potential to be used in diagnostic and therapeutic telegaming for PD patients.
临床远程游戏集成了远程医疗和视频游戏,当提供者通过网络通信诊断、监测和治疗各种健康问题时,可以为患者提供更方便、更愉快的体验。近年来,临床远程游戏系统已应用于物理治疗和康复、心理健康评估以及肥胖和糖尿病的预防和管理。帕金森病(PD)适合开发新的临床远程游戏应用,因为已知PD患者有运动症状,可以通过物理治疗改善。最近的研究表明,感觉加工缺陷也可能在这些运动障碍中发挥重要作用,因为成功的运动功能需要多感觉整合。在本文中,我们描述了一个新的网络支持的软件系统,它使用临床远程游戏来评估和提高用户的多感觉整合能力。该软件有潜力用于PD患者的诊断和治疗远程游戏。
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引用次数: 0
Photovoltaic restoration of high visual acuity in rats with retinal degeneration 视网膜变性大鼠高视力的光电恢复
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146606
H. Lorach, Georges A. Goetz, Y. Mandel, R. Smith, David Boinagrov, X. Lei, R. Dalal, P. Huie, T. Kamins, J. Harris, K. Mathieson, A. Sher, D. Palanker
Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.
视网膜变性患者由于光感受器的逐渐消亡而丧失视力。电刺激残存的视网膜神经元为传递视觉信息提供了另一种途径。我们开发了视网膜下光伏阵列,将脉冲光转换为双相脉冲电流,以刺激附近的视网膜内神经元。明亮的脉冲照明由视频护目镜的图像投影提供,并通过使用近红外(NIR, 880-915nm)光避免恐光效应。体外和体内实验表明,网络介导的视网膜刺激保留了自然视觉的许多特征,如闪烁融合、对静态图像的适应,以及最重要的高空间分辨率。我们的70μm像素植入物使视网膜变性大鼠的视力恢复到正常水平的一半。这些无线阵列易于植入和平铺以覆盖大视野,再加上它们的高分辨率,为高度功能性的视力恢复打开了大门。
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引用次数: 0
Adaptive control of a robotic exoskeleton for neurorehabilitation 神经康复机器人外骨骼的自适应控制
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146745
Tommaso Proietti, N. Jarrassé, A. Roby-Brami, G. Morel
Neurorehabilitation efficiency increases with therapy intensity and subject's involvement during physical exercises. Robotic exoskeletons could bring both features, if they could adapt the level of assistance to patient's motor capacities. To this aim, we developed an exoskeleton controller, based on adaptive techniques, that can actively modulate the stiffness of the robotic device in function of the subject's activity. We tested this control law on one healthy subject with an upper-limb exoskeleton. The experiment consisted in learning a trajectory imposed by the robot. The early results show the different features allowed by our controller with respect to controllers commonly used for neurorehabilitation with exoskeletons.
神经康复效率随治疗强度和受试者参与体育锻炼而增加。如果机器人外骨骼能够根据病人的运动能力调整辅助水平,它们就能实现这两种功能。为此,我们开发了一种基于自适应技术的外骨骼控制器,该控制器可以根据受试者的活动主动调节机器人设备的刚度。我们在一个有上肢外骨骼的健康受试者身上测试了这个控制律。实验包括学习机器人施加的轨迹。早期的结果显示了我们的控制器与通常用于外骨骼神经康复的控制器所允许的不同特征。
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引用次数: 21
LFPs network of hippocampal-prefrontal circuit during working memory task 工作记忆任务中海马-前额叶回路的lfp网络
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146791
Tiaotiao Liu, X. Tian
Working memory (WM) provides temporary information storage for performance of cognitive tasks. Neural signals in hippocampus-prefrontal cortex (HPC-PFC) circuit interact and construct a network. The question raised here is how the neural signals connect and transfer in the HPC-PFC network to perform a WM task? In this study, 32-channel local field potentials (LFPs) were recorded with two electrode arrays respectively implanted in HPC and PFC during a rat Y-maze working memory task. The principle frequency band of LFPs during the task was theta, determined via short-time Fourier transform. Functional connectivity strength was further calculated quantitatively and a causal network was defined by directed transfer function (DTF). The information transfer in the network was described by information flow. The results show that (1)the DTF curve peaked before the choice point. (2) The information flow in working memory was from HPC to PFC. These findings suggest that the functional connectivity strengthens at WM state and HPC is the WM information source in the HPC- PFC network.
工作记忆(WM)为认知任务的执行提供临时的信息存储。海马-前额叶皮层(HPC-PFC)回路中的神经信号相互作用并形成网络。这里提出的问题是神经信号如何在HPC-PFC网络中连接和传输以执行WM任务?本研究在大鼠y迷宫工作记忆任务中,分别在HPC和PFC植入两个电极阵列,记录32通道局部场电位(LFPs)。通过短时傅里叶变换确定LFPs在任务期间的主频带为θ。进一步定量计算功能连通性强度,并通过有向传递函数(DTF)定义因果网络。用信息流来描述网络中的信息传递。结果表明:(1)DTF曲线在选择点前达到峰值。(2)工作记忆中的信息流由HPC向PFC流动,说明在WM状态下功能连通性增强,HPC是HPC- PFC网络中WM信息源。
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引用次数: 0
Neural representations of movement intentions during brain-controlled self-motion 脑控自我运动中运动意图的神经表征
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146601
R. So, Zhiming Xu, C. Libedinsky, Kyaw Kyar Toe, K. Ang, S. Yen, Cuntai Guan
Using a brain-machine interface (BMI), a non-human primate (NHP) was trained to control a mobile robotic platform in real time using spike activity from the motor cortex, enabling self-motion through brain-control. The decoding model was initially trained using neural signals recorded when the NHP controlled the platform using a joystick. Using this decoding model, we compared the performance of the BMI during brain control with and without the use of a dummy joystick, and found that the success ratio dropped by 40% and time taken increased by 45% when the dummy joystick was removed. Performance during full brain control was only restored after a recalibration of the decoding model. We aimed to understand the differences in the underlying neural representations of movement intentions with and without the use of a dummy joystick, and showed that there were significant changes in both directional tuning, as well as global firing rates. These results indicate that the strategies used by the NHP for self-motion were different depending on whether a dummy joystick was present. We propose that a recalibration of the decoding model is an important step during the implementation of a BMI system for self-motion.
使用脑机接口(BMI),训练非人类灵长类动物(NHP)利用运动皮层的脉冲活动实时控制移动机器人平台,从而通过大脑控制实现自我运动。解码模型最初是使用NHP使用操纵杆控制平台时记录的神经信号进行训练的。利用这个解码模型,我们比较了使用和不使用假操纵杆时大脑控制期间BMI的表现,发现当假操纵杆被移除时,成功率下降了40%,所需时间增加了45%。在完全大脑控制期间的表现只有在解码模型重新校准后才能恢复。我们的目的是了解在使用和不使用虚拟操纵杆的情况下,运动意图的潜在神经表征的差异,并表明方向调整和整体射击速率都有显著变化。这些结果表明,NHP用于自我运动的策略取决于是否存在虚拟操纵杆。我们提出,解码模型的重新校准是实现自我运动的BMI系统的重要步骤。
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引用次数: 5
Controlling cell functions by light 通过光控制细胞功能
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146695
G. Lanzani, M. Antognazza, N. Martino, D. Ghezzi, F. Benfenati
The capability to selectively affect vital functions in cell networks and sub-cell compartments in vitro or in vivo is a mission critical tool in neuroscience and medicine. Optical excitation is one of the main strategies used to achieve high spatial and temporal resolution. In the following we describe recent results and future approaches of cell photostimulation mediated by organic semiconducting polymers.
在体外或体内选择性影响细胞网络和亚细胞区室的重要功能的能力是神经科学和医学的关键任务工具。光激发是实现高时空分辨率的主要方法之一。在下面,我们描述了由有机半导体聚合物介导的细胞光刺激的最新结果和未来的方法。
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引用次数: 2
A collaborative Brain-Computer Interface for improving group detection of visual targets in complex natural environments 一种用于改善复杂自然环境中视觉目标群体检测的协同脑机接口
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146551
D. Valeriani, R. Poli, C. Cinel
Detecting a target in a complex environment can be a difficult task, both for a single individual and a group, especially if the scene is very rich of structure and there are strict time constraints. In recent research, we have demonstrated that collaborative Brain-Computer Interfaces (cBCIs) can use neural signals and response times to estimate the decision confidence of participants and use this to improve group decisions in visual-matching and visual-search tasks with artificial stimuli. This paper extends that work in two ways. Firstly, we use a much harder target detection task where observers are presented with complex natural scenes where targets are very difficult to identify. Secondly, we complement the neural and behavioural information used in our previous cBCIs with physiological features representing eye movements and eye blinks of participants in the period preceding their decisions. Results obtained with 10 participants indicate that the proposed cBCI improves decision errors by up to 3.4% (depending on group size) over group decisions made by a majority vote. Furthermore, results show that providing the system with information about eye movements and blinks further significantly improves performance over our best previously reported method.
在一个复杂的环境中检测目标是一项艰巨的任务,无论是对一个人还是一个群体,特别是如果场景非常丰富的结构和有严格的时间限制。在最近的研究中,我们已经证明了协作脑机接口(cbci)可以使用神经信号和响应时间来估计参与者的决策信心,并利用它来改善具有人工刺激的视觉匹配和视觉搜索任务中的群体决策。本文从两个方面扩展了这一工作。首先,我们使用了一个更困难的目标检测任务,在这个任务中,观察者面对的是非常复杂的自然场景,目标很难识别。其次,我们补充了之前cbci中使用的神经和行为信息,其中包括参与者在做出决定之前的一段时间内的眼动和眨眼的生理特征。10名参与者获得的结果表明,与多数投票做出的群体决策相比,拟议的cBCI可将决策错误提高3.4%(取决于群体规模)。此外,结果表明,为系统提供有关眼球运动和眨眼的信息,比我们之前报道的最佳方法进一步显著提高了性能。
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引用次数: 18
Intuitive motion classification from EMG for the 3-D arm motions coordinated by multiple DoFs 基于肌电图对多自由度协调的三维手臂运动进行直观分类
Pub Date : 2015-04-22 DOI: 10.1109/NER.2015.7146753
Qin Zhang, C. Xiong, Chengfei Zheng
Surface Electromyography (EMG) has been considered as a viable human-machine interface in the context of human-centered robotics. In order to interpret human muscle activities into motion intentions, various pattern classification methods was proposed for human motion/gesture classification, which provided binary command for myoelectric control. To obtain complex motions coordinated by multiple DoFs, single DoF was usually sequentially classified and activated, which is not intuitive and efficient comparing with the natural motor strategy of the human. In this work, we investigated the motion classification methods from EMG for intuitive and simultaneous activation of multiple DoFs during 3-D arm motions. In the experiments, all motions were performed naturally rather than under the condition of maximum muscle contractions or other kinematic constraints. The combination of two EMG time-domain features after principal component analysis (PCA) processing is considered as the suitable choice considering both the classification accuracy and feasibility for robot control. For the motion classification method, least-square support vector machine (LS-SVM) represents higher classification accuracy for five arm motion classification across eight subjects with respect to other four methods which were popularly used in the previous works. The proposed method is hopefully applied in a EMG-driven simultaneous and proportional kinematics estimation systems for decoding model selection according to the motion intention.
表面肌电图(EMG)已被认为是在以人为中心的机器人环境下可行的人机界面。为了将人体肌肉活动解释为运动意图,提出了多种模式分类方法进行人体运动/手势分类,为肌电控制提供了二进制指令。为了获得由多个自由度协调的复杂运动,通常对单个自由度进行顺序分类和激活,与人类的自然运动策略相比,这种方法并不直观和高效。在这项工作中,我们研究了基于肌电图的运动分类方法,以直观地同时激活三维手臂运动中的多个DoFs。在实验中,所有的运动都是自然进行的,而不是在最大肌肉收缩或其他运动学约束的条件下进行的。考虑到分类精度和机器人控制的可行性,结合主成分分析(PCA)处理后的两种肌电信号时域特征是比较合适的选择。对于运动分类方法,最小二乘支持向量机(least-square support vector machine, LS-SVM)相对于以往常用的4种方法,在8个受试者的5个手臂运动分类中具有更高的分类精度。该方法有望应用于肌电驱动的同步和比例运动估计系统中,用于根据运动意图选择解码模型。
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引用次数: 3
期刊
2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)
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