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Assessment of Self-Medication Behaviour in Response to Dental Pain in Two Populations, France 评估自我用药行为,以应对牙痛在两个人群,法国。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-04 DOI: 10.1016/j.identj.2026.109418
Louise Le Texier , Chantal Savanovitch , Emmanuel Nicolas , Pierre-Yves Cousson

Introduction and aims

Self-medication appears to be a common practice for dental pain. However, in France, its prevalence and patterns in dentistry have never been studied. The primary objective was to assess the prevalence and self-medication behaviours in two at-risk populations: patients consulting for acute pulpal or periapical pain and patients with dental anxiety requiring treatment under general anaesthesia. The secondary objective was to examine the influence of socio-behavioural factors on these practices.

Method

Between April 2021 and May 2023, the behaviours of two at-risk population regarding self-medication were analysed in a cross-sectional observational study. The first population regrouped patients referred to an endodontic postemergency care unit after visiting the emergency service of a dental hospital. These patients were referred due to acute pulpal or periapical pain (Endodontic Group). The second population regrouped patients referred to a special care unit for dental treatment under general anaesthesia due to dental anxiety (Anxiety Group). Self-medication behaviours of the two at-risk populations were analysed with 5 self-administered questionnaires (self-medication, EPICES, IDAF-4C, Pain Catastrophizing Scale, Socio-demographic data). Comparisons between the two population were done using Pearson’s chi-square and Student’s t tests.

Results

During the study period, 43 patients were included in the endodontic group and 66 in the anxiety group. Socio-demographic and behavioural data differed between the two groups. However, self-medication prevalence was similar (51.2% in the Endodontic Group vs 45.5% in the Anxiety Group), as were self-medication behaviours (types and number of substances used, methods of acquisition, knowledge). No socio-demographic or behavioural factors explained these attitudes.

Conclusion

Self-medication in dentistry is often overlooked or poorly managed. Preventive measures and patient education on the proper use of medication are essential.

Clinical relevance

Standardized cooperation protocols should be developed involving dentists and community pharmacists to optimize the management of patients suffering from dental pain.
自我药物治疗是治疗牙痛的常用方法。然而,在法国,其在牙科的流行程度和模式从未研究过。主要目的是评估两个高危人群的患病率和自我用药行为:急性牙髓或根尖周疼痛患者和需要全身麻醉治疗的牙科焦虑患者。第二个目标是审查社会行为因素对这些做法的影响。方法:采用横断面观察研究方法,对2021年4月至2023年5月期间两名高危人群的自我药疗行为进行分析。第一组患者在访问牙科医院的急诊服务后转介到牙髓急诊后护理单位。这些患者因急性牙髓或根尖周疼痛而转诊(根管组)。第二组患者因牙齿焦虑而在全身麻醉下转到特殊护理单位接受牙科治疗(焦虑组)。采用5份自我调查问卷(自我药疗、EPICES、IDAF-4C、疼痛灾变量表、社会人口统计数据)分析两种高危人群的自我药疗行为。两个群体之间的比较使用Pearson卡方检验和学生t检验。结果:研究期间,牙髓治疗组43例,焦虑组66例。社会人口学和行为数据在两组之间有所不同。然而,自我药疗患病率相似(牙髓治疗组为51.2%,焦虑组为45.5%),自我药疗行为(使用物质的类型和数量,获取方法,知识)也是如此。没有任何社会人口或行为因素可以解释这些态度。结论:牙科自我药疗常被忽视或管理不善。预防措施和对患者进行正确用药教育至关重要。临床相关性:应制定牙医和社区药剂师参与的标准化合作协议,以优化对牙痛患者的管理。
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引用次数: 0
Identification of Micrometastasis in Cervical Lymph Nodes – A Machine Learning-Based Approach 颈部淋巴结微转移的鉴别——一种基于机器学习的方法。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-04 DOI: 10.1016/j.identj.2025.109399
Kuntala Mondal , Sowmya SV , Dominic Augustine , BR Karthikeyan , Venkata Suresh Venkataiah , Shankargouda Patil

Introduction and aim

Oral squamous cell carcinoma (OSCC) rates have been on the rise globally due to a lack of health care facilities, unaffordable treatment expenses and diagnosis at the advanced stages. Cervical lymph node metastasis is a critically important prognostic factor for OSCC patients. Micrometastatic deposits critically shape clinical staging and treatment choices. Microscopic examination for micrometastases is a slow, labour-intensive, and error-prone process. The use of machine learning on lymph node photomicrographs overcomes manual limitations and enables automated detection of metastatic tissue. This current study employed a convolutional neural network (CNN) algorithm to detect micrometastasis in lymph node sections.

Methods

Fifty lymph node archival tissue sections of 30 OSCC cases with modified Papanicolaou (PAP) staining were considered, of which 25 nodes each were metastatic and non-metastatic cases. A comprehensive set of 500 images was acquired using an Olympus Research Microscope (BX53F2), which was equipped with a CCD camera (Jenoptix Gryphax Arktur).

Results

CNN based algorithm was found to be superior compared to the manual method in the detection of micrometastasis. The validation accuracy of the model was 89.36%, classification accuracy of 85%, with a sensitivity of 0.8667 and specificity of 0.8333. Early micrometastasis detection aids tumour upstaging (3 cases), impacting OSCC treatment and prognosis.

Conclusion

The ROC AUC value of 0.9056 indicates a high level of discriminative capability across thresholds, supporting the robustness of the model in detecting micrometastasis. This CNN model has been justified for improved diagnosis and treatment planning of clinically N0 OSCC patients.

Clinical relevance

The CNN model can function as a supplementary tool to assist pathologic diagnosis, particularly for large-scale populations. CNNs, known for analysing intricate image patterns, can support pathologists by streamlining the identification and evaluation of disease conditions. This support enhances diagnostic efficiency and improves accuracy when managing vast data volumes.
简介和目的:口腔鳞状细胞癌(OSCC)的发病率一直在全球范围内上升,由于缺乏卫生保健设施,负担不起的治疗费用和晚期诊断。宫颈淋巴结转移是OSCC患者预后的重要因素。微转移性沉积对临床分期和治疗选择至关重要。微转移的显微检查是一个缓慢、费力且容易出错的过程。在淋巴结显微照片上使用机器学习克服了人工限制,实现了转移组织的自动检测。本研究采用卷积神经网络(CNN)算法检测淋巴结切片的微转移。方法:对30例OSCC经改良巴氏染色的50例淋巴结档案组织切片进行分析,其中转移性和非转移性各25例。使用配备CCD相机(Jenoptix Gryphax Arktur)的奥林巴斯研究显微镜(BX53F2)采集了500张完整的图像。结果:基于CNN的算法在微转移检测方面优于手工方法。该模型的验证准确率为89.36%,分类准确率为85%,灵敏度为0.8667,特异性为0.8333。早期微转移检测有助于肿瘤的早期分期(3例),影响OSCC的治疗和预后。结论:ROC AUC值为0.9056,表明该模型具有较高的跨阈值判别能力,支持了该模型检测微转移的稳健性。该CNN模型已被证明可以改善临床no0 OSCC患者的诊断和治疗计划。临床相关性:CNN模型可以作为辅助病理诊断的辅助工具,特别是对于大规模人群。cnn以分析复杂的图像模式而闻名,可以通过简化疾病状况的识别和评估来支持病理学家。这种支持提高了诊断效率,并在管理大量数据时提高了准确性。
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引用次数: 0
Combined Effects of Zinc Compounds and Xylitol on the Enzymatic and Anticandidal Activities of Salivary Antimicrobials 锌化合物和木糖醇对唾液抗菌剂酶活性和抗药活性的联合影响。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-04 DOI: 10.1016/j.identj.2026.109415
Yu-Jin Park , Yoon-Young Kim , Ji-Youn Chang , Jae Wook Lee , Hong-Seop Kho

Objectives

To investigate the combined effects of zinc compounds and xylitol on the enzymatic and anticandidal activities of salivary antimicrobials.

Methods

Four zinc compounds and/or xylitol were incubated with hen egg-white lysozyme (HEWL), bovine lactoperoxidase, the glucose oxidase–mediated peroxidase (GO-PO) system, and human whole saliva. Their enzymatic activities were then assessed. The effects of xylitol on the minimum inhibitory concentration (MIC) and fungicidal activities of zinc compounds were tested against Candida albicans strains. The combined effects of zinc compounds and xylitol on the candidacidal activities of HEWL, the peroxidase system, and the GO-PO system were also evaluated.

Results

Zinc compounds increased lysozyme activity but reduced peroxidase activity. Xylitol exerted opposite effects, although it did not reverse the effects of zinc compounds. While xylitol had no effect on the MIC results of zinc compounds against C albicans, it significantly increased their candidacidal activities. Furthermore, the fungicidal activities of HEWL and the peroxidase system were significantly increased when zinc compounds were combined with xylitol.

Conclusions

Zinc compounds combined with xylitol increased lysozyme activity but reduced peroxidase activity. The combination synergistically increased the fungicidal activities of HEWL and the peroxidase system.

Clinical relevance

The combination of zinc compounds and xylitol may represent a potential candidate for topical antifungal strategies for preventing or managing oral candidiasis, especially in geriatric populations.
目的:研究锌化合物和木糖醇对唾液抗菌剂酶活性和抗念珠菌活性的联合作用。方法:用蛋清溶菌酶(HEWL)、牛乳过氧化物酶(GO-PO)、葡萄糖氧化酶介导的过氧化物酶(GO-PO)体系和人全唾液培养4种锌化合物和/或木糖醇。然后评估它们的酶活性。研究了木糖醇对锌化合物对白色念珠菌最小抑菌浓度(MIC)和抑菌活性的影响。研究了锌化合物和木糖醇对hhl、过氧化物酶体系和GO-PO体系的活性的影响。结果:锌化合物提高溶菌酶活性,降低过氧化物酶活性。木糖醇发挥了相反的作用,尽管它没有逆转锌化合物的作用。木糖醇对锌化合物对白色念珠菌的MIC结果没有影响,但显著提高了锌化合物对白色念珠菌的杀灭活性。此外,当锌化合物与木糖醇结合时,hhl和过氧化物酶系统的杀真菌活性显著提高。结论:锌化合物与木糖醇复合可提高溶菌酶活性,降低过氧化物酶活性。该组合协同提高了hhl和过氧化物酶系统的杀真菌活性。临床意义:锌化合物和木糖醇的组合可能代表了预防或管理口腔念珠菌病的局部抗真菌策略的潜在候选人,特别是在老年人群中。
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引用次数: 0
Nitrogen Species Modulate Macrophage ER Stress to Preserve Alveolar Bone: A Translational Adjunct for Periodontal Care 氮调节巨噬细胞内质网应激以保护牙槽骨:牙周护理的翻译辅助。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-03 DOI: 10.1016/j.identj.2025.109400
Zhixin Liu , Laidi Wu , Ming Luo , Ollie Yiru Yu , Xinpei Lu , Yingguang Cao , Ke Song

Background

Periodontitis remains a leading cause of tooth loss, yet conventional therapeutic procedures show limited impact on host immune dysregulation and alveolar bone preservation.

Objectives

To evaluate the feasibility and efficacy of a chairside-oriented, plasma-based nitrogen species implantation (PBNI) approach for nitric oxide (NO) delivery and to delineate the underlying host-modulatory mechanisms relevant to periodontal care.

Methods

In a ligature-induced mouse periodontitis model, we assessed inflammatory infiltration, leukocyte recruitment, macrophage polarization, and alveolar bone outcomes after PBNI. Transcriptomics of bone-marrow-derived macrophages (BMDMs) and targeted genetic perturbation probed the underlying pathways. Quantitative data were analyzed using appropriate statistical methods.

Results

PBNI reduced gingival inflammatory infiltration, decreased neutrophil/macrophage recruitment, promoted M2 repolarization, and increased alveolar bone volume. RNA sequencing revealed suppression of endoplasmic reticulum (ER) stress signatures with upregulation of Phlda1. Mechanistically, PBNI-derived NO correlates with elevated Phlda1 and downregulated ER-stress hub genes (Chac1, Ddit3/CHOP, Trib3, Herpud1, Sesn2, Hspa5/GRP78, Hyou1, Asns) in M1 macrophages. Genetic silencing of Phlda1 abrogated these benefits, establishing a required NO/Phlda1/ER-stress attenuation axis.

Conclusions

By engaging the NO–Phlda1 axis and being associated with reduced macrophage ER stress, PBNI may serve as a practical adjunct strategy with potential to improve periodontal outcomes.

Clinical relevance

These preclinical data support PBNI as a chairside host-modulatory adjunct to non-surgical periodontal therapy by restoring immune homeostasis and creating a bone-forming microenvironment. The approach is conceptually compatible with short, operator-delivered applications and standard infection-control workflows.
背景:牙周炎仍然是牙齿脱落的主要原因,然而传统的治疗方法对宿主免疫失调和牙槽骨保存的影响有限。目的:评估椅子导向、基于等离子体的氮种植入(PBNI)方法用于一氧化氮(NO)递送的可行性和有效性,并描述与牙周保健相关的潜在宿主调节机制。方法:在结扎诱导的小鼠牙周炎模型中,我们评估了PBNI后的炎症浸润、白细胞募集、巨噬细胞极化和牙槽骨结局。骨髓源性巨噬细胞(bmdm)的转录组学和靶向遗传扰动探索了潜在的途径。采用适当的统计方法对定量资料进行分析。结果:PBNI减少牙龈炎症浸润,减少中性粒细胞/巨噬细胞募集,促进M2复极化,增加牙槽骨体积。RNA测序显示,Phlda1上调可抑制内质网(ER)应激信号。在机制上,pbni衍生的NO与M1巨噬细胞中Phlda1升高和er应激中枢基因(Chac1、Ddit3/CHOP、Trib3、Herpud1、Sesn2、Hspa5/GRP78、Hyou1、Asns)下调相关。Phlda1基因沉默消除了这些好处,建立了一个必需的NO/Phlda1/ er应力衰减轴。结论:通过参与NO-Phlda1轴并与巨噬细胞内质网应激降低相关,PBNI可能作为一种实用的辅助策略,具有改善牙周预后的潜力。临床相关性:这些临床前数据支持PBNI通过恢复免疫稳态和创造骨形成微环境,作为非手术牙周治疗的主持侧宿主调节辅助手段。从概念上讲,该方法与运营商交付的短应用程序和标准感染控制工作流程兼容。
{"title":"Nitrogen Species Modulate Macrophage ER Stress to Preserve Alveolar Bone: A Translational Adjunct for Periodontal Care","authors":"Zhixin Liu ,&nbsp;Laidi Wu ,&nbsp;Ming Luo ,&nbsp;Ollie Yiru Yu ,&nbsp;Xinpei Lu ,&nbsp;Yingguang Cao ,&nbsp;Ke Song","doi":"10.1016/j.identj.2025.109400","DOIUrl":"10.1016/j.identj.2025.109400","url":null,"abstract":"<div><h3>Background</h3><div>Periodontitis remains a leading cause of tooth loss, yet conventional therapeutic procedures show limited impact on host immune dysregulation and alveolar bone preservation.</div></div><div><h3>Objectives</h3><div>To evaluate the feasibility and efficacy of a chairside-oriented, plasma-based nitrogen species implantation (PBNI) approach for nitric oxide (NO) delivery and to delineate the underlying host-modulatory mechanisms relevant to periodontal care.</div></div><div><h3>Methods</h3><div>In a ligature-induced mouse periodontitis model, we assessed inflammatory infiltration, leukocyte recruitment, macrophage polarization, and alveolar bone outcomes after PBNI. Transcriptomics of bone-marrow-derived macrophages (BMDMs) and targeted genetic perturbation probed the underlying pathways. Quantitative data were analyzed using appropriate statistical methods.</div></div><div><h3>Results</h3><div>PBNI reduced gingival inflammatory infiltration, decreased neutrophil/macrophage recruitment, promoted M2 repolarization, and increased alveolar bone volume. RNA sequencing revealed suppression of endoplasmic reticulum (ER) stress signatures with upregulation of Phlda1. Mechanistically, PBNI-derived NO correlates with elevated Phlda1 and downregulated ER-stress hub genes (Chac1, Ddit3/CHOP, Trib3, Herpud1, Sesn2, Hspa5/GRP78, Hyou1, Asns) in M1 macrophages. Genetic silencing of Phlda1 abrogated these benefits, establishing a required NO/Phlda1/ER-stress attenuation axis.</div></div><div><h3>Conclusions</h3><div>By engaging the NO–Phlda1 axis and being associated with reduced macrophage ER stress, PBNI may serve as a practical adjunct strategy with potential to improve periodontal outcomes.</div></div><div><h3>Clinical relevance</h3><div>These preclinical data support PBNI as a chairside host-modulatory adjunct to non-surgical periodontal therapy by restoring immune homeostasis and creating a bone-forming microenvironment. The approach is conceptually compatible with short, operator-delivered applications and standard infection-control workflows.</div></div>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 2","pages":"Article 109400"},"PeriodicalIF":3.7,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Mechanism of Oral Cancer With Shikonin Based on the Network Pharmacology and Molecular Docking Technology 基于网络药理学和分子对接技术探索紫草素治疗口腔癌的作用机制。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-02 DOI: 10.1016/j.identj.2025.103954
Lin Hou , Kun Wang , Yusheng Wang , Jing Li , Lin Guo , Qingliang Zhao

Objectives

To explore the underlying mechanisms of shikonin in treating oral cancer using network pharmacology and molecular docking methods.

Materials and methods

Targets of shikonin were obtained from the TCMSP, BATMAN, ChEMBL, PharmMapper and HERB databases. Targets of oral cancer were gathered from the OMIM, STITCH, GeneCards and Drugbank databases. The intersection targets of shikonin and oral cancer were obtained for subsequent analysis. The intersecting targets of shikonin and oral cancer were entered into the DAVID database and used its functions to perform Gene Ontology (GO) and Kyoto encyclopaedia of genes and genomes (KEGG) enrichment analysis on the intersection targets to obtain the relevant pathways and biological functions of shikonin in the treatment of oral cancer. The protein-protein interaction (PPI) network of shikonin and oral cancer targets was constructed in STRING platform. Subsequently, using Cytoscape 3.8.0 to obtain the key targets of shikonin and oral cancer. Finally, molecular docking and molecular dynamics simulations were used to evaluate the strength of binding between shikonin and key targets, as well as the hydrogen bonds involved.

Results

In total, 481 targets were screened for shikonin, and 10,058 targets were identified for oral cancer. By GO and KEGG analysis, the targets of shikonin and oral cancer may be involved in the mediation of apoptosis, inflammation and immune response. And the associated signalling pathways that targets may be involved in the treatment of oral cancer, including the FoxO signalling pathway, HIF-1 signalling pathway, TNF signalling pathway, and Th17 cell differentiation, etc. Cytoscape software screened the key genes including AKT1, MAPK1, CXCR4, CXCL8, CCL3, CCL4, CCL5, CYBB, BCL2, NOX1, HIF-1, TP53. The results of molecular docking and molecular dynamics simulations showed that shikonin exhibits good binding interactions with CCL3, AKT1 and NOX1.

Conclusions

Mulitple molecular mechanisms involved in oral cancer management with shikonin have been elucidated providing a glimpse og the underlying therapeutic targets for the disease..
目的:利用网络药理学和分子对接方法,探讨紫草素治疗口腔癌的作用机制。材料和方法:从TCMSP、BATMAN、ChEMBL、PharmMapper和HERB数据库中获得紫草素的靶点。口腔癌靶点收集自OMIM、STITCH、GeneCards和Drugbank数据库。得到紫草素与口腔癌的交叉靶点,进行后续分析。将紫草素与口腔癌的相交靶点录入DAVID数据库,利用其功能对相交靶点进行基因本体(GO)和京都基因基因组百科全书(KEGG)富集分析,获得紫草素治疗口腔癌的相关通路和生物学功能。在STRING平台上构建了紫草素与口腔癌靶点蛋白-蛋白相互作用(PPI)网络。随后,利用Cytoscape 3.8.0获得紫草素与口腔癌的关键靶点。最后,通过分子对接和分子动力学模拟来评估紫草素与关键靶点之间的结合强度,以及所涉及的氢键。结果:共筛选到紫草素481个靶点,鉴定到口腔癌靶点10058个。通过GO和KEGG分析,紫草素与口腔癌的作用靶点可能参与介导细胞凋亡、炎症和免疫应答。而相关的靶点信号通路可能参与口腔癌的治疗,包括FoxO信号通路、HIF-1信号通路、TNF信号通路、Th17细胞分化等。Cytoscape软件筛选的关键基因包括AKT1、MAPK1、CXCR4、CXCL8、CCL3、CCL4、CCL5、CYBB、BCL2、NOX1、HIF-1、TP53。分子对接和分子动力学模拟结果表明,紫草素与CCL3、AKT1和NOX1具有良好的结合作用。结论:紫草素在口腔癌治疗中的多种分子机制已经被阐明,为该疾病的潜在治疗靶点提供了一瞥。
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引用次数: 0
Evaluating Retrieval-Augmented Generation-Large Language Models for Infective Endocarditis Prophylaxis: Clinical Accuracy and Efficiency. 评估检索增强代大语言模型对感染性心内膜炎的预防:临床准确性和效率。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-12-25 DOI: 10.1016/j.identj.2025.109344
Paak Rewthamrongsris, Vivat Thongchotchat, Jirayu Burapacheep, Vorapat Trachoo, Zohaib Khurshid, Thantrira Porntaveetus

Introduction and aims: The use of large language models (LLMs) in healthcare is expanding. Retrieval-augmented generation (RAG) addresses key LLM limitations by grounding responses in domain-specific, up-to-date information. This study evaluated RAG-augmented LLMs for infective endocarditis (IE) prophylaxis in dental procedures, comparing their performance with non-RAG models assessed in our previous publication using the same question set. A pilot study also explored the utility of an LLM as a clinical decision support tool.

Methods: An established IE prophylaxis question set from previous research was used to ensure comparability. Ten LLMs integrated with RAG were tested using MiniLM L6 v2 embeddings and FAISS to retrieve relevant content from the 2021 American Heart Association IE guideline. Models were evaluated across five independent runs, with and without a preprompt ('You are an experienced dentist'), a prompt-engineering technique used in previous research to improve LLMs accuracy. Three RAG-LLMs were compared to their native (non-RAG) counterparts benchmarked in the previous study. In the pilot study, 10 dental students (5 undergraduate, 5 postgraduate in oral and maxillofacial surgery) completed the questionnaire unaided, then again with assistance from the best performing LLM. Accuracy and task time were measured.

Results: DeepSeek Reasoner achieved the highest mean accuracy (83.6%) without preprompting, while Grok 3 beta reached 90.0% with preprompting. The lowest accuracy was observed for Claude 3.7 Sonnet, at 42.1% without preprompts and 47.1% with preprompts. Preprompting improved performance across all LLMs. RAG's impact on accuracy varied by model. Claude 3.7 Sonnet showed the highest response consistency without preprompting; with preprompting, Claude 3.5 Sonnet and DeepSeek Reasoner matched its performance. DeepSeek Reasoner also had the slowest response time. In the pilot study, LLM support slightly improved postgraduate accuracy, slightly reduced undergraduate accuracy, and significantly increased task time for both.

Conclusion: While RAG and prompting enhance LLM performance, real-world utility in education remains limited.

Clinical relevance: LLMs with RAG provide rapid and accessible support for clinical decision-making. Nonetheless, their outputs are not always accurate and may not fully reflect evolving medical and dental knowledge. It is crucial that clinicians and students approach these tools with digital literacy and caution, ensuring that professional judgment remains central.

简介和目标:大型语言模型(llm)在医疗保健领域的使用正在扩大。检索增强生成(RAG)通过在特定于领域的最新信息中建立响应来解决LLM的关键限制。本研究评估了rag增强llm在牙科手术中预防感染性心内膜炎(IE)的作用,并将其与我们之前发表的使用相同问题集评估的非rag模型的性能进行了比较。一项试点研究还探讨了法学硕士作为临床决策支持工具的效用。方法:采用先前研究中建立的IE预防问题集以确保可比性。使用MiniLM L6 v2嵌入和FAISS对10个集成RAG的llm进行测试,以检索2021年美国心脏协会IE指南的相关内容。模型在五个独立的运行中进行评估,有或没有预提示(“你是一位经验丰富的牙医”),这是一种提示工程技术,在之前的研究中用于提高llm的准确性。将三个rag - llm与先前研究中基准的本地(非rag)对应物进行比较。在初步研究中,10名口腔颌面外科专业的学生(5名本科生,5名研究生)在没有帮助的情况下完成问卷,然后在表现最好的LLM的帮助下再次完成问卷。测量准确率和任务时间。结果:在没有预提示的情况下,DeepSeek Reasoner的平均准确率最高(83.6%),而在有预提示的情况下,Grok 3 beta达到90.0%。克劳德3.7十四行诗的准确率最低,无预提示为42.1%,有预提示为47.1%。预提示提高了所有llm的性能。RAG对精度的影响因模型而异。未提示的Claude 3.7 Sonnet反应一致性最高;在预先提示下,克劳德3.5十四行诗和DeepSeek推理机的表现与之相当。DeepSeek Reasoner的响应时间也最慢。在试点研究中,LLM略微提高了研究生的准确率,略微降低了本科生的准确率,并显著增加了两者的任务时间。结论:虽然RAG和prompt提高了LLM的绩效,但在教育中的实际效用仍然有限。临床相关性:具有RAG的llm为临床决策提供快速和可访问的支持。然而,它们的产出并不总是准确的,可能不能完全反映不断发展的医学和牙科知识。至关重要的是,临床医生和学生应以数字素养和谨慎态度对待这些工具,确保专业判断仍然是核心。
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引用次数: 0
Prompt-Driven ChatGPT Carbon Calculator for Dental Practices: Estimation and Tailored Improvement Strategies. 牙科实践的即时驱动ChatGPT碳计算器:估计和量身定制的改进策略。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-01 Epub Date: 2026-01-03 DOI: 10.1016/j.identj.2025.103979
Brett Duane, Paul Ashley, James Larkin

Introduction and aims: This study investigates the feasibility of applying ChatGPT, a generative artificial intelligence (AI) language model, to develop a user-friendly carbon footprint calculator tailored for dental practices. Building on a previously developed Excel-based tool, the research aimed to evaluate ChatGPT's capacity to generate accurate emissions estimates and sustainability recommendations using different prompting strategies.

Methods: Three prompting variants were tested. Variant 1 employed an unstructured request to assess general responses. Variant 2 used structured data entry with predefined emission factors. Variant 3 combined structured input with instructions to rely exclusively on outputs from a previously validated sustainability tool. ChatGPT-generated results were compared with the Excel benchmark, focusing on accuracy, contextual relevance and alignment with peer-reviewed guidance.

Results: Unstructured prompts (Variant 1) produced general recommendations of limited contextual relevance. Structured prompts improved both accuracy and specificity. Variant 2 generated tailored outputs using emission factors, while Variant 3 provided detailed, evidence-based recommendations consistent with established literature. Across variants, ChatGPT's carbon footprint estimates were largely comparable to the Excel benchmark, with only minor discrepancies in waste-related emissions.

Conclusion: Structured prompting significantly enhances ChatGPT's performance in generating reliable carbon footprint data and recommendations for dental practices. When supported by transparent emission factors and credible literature, generative AI tools can increase access to environmental data, support sustainability decision-making and facilitate climate action in clinical contexts. However, limitations remain, including risks of inaccurate outputs ('hallucinations') and regional generalisations. Effective use requires prompt literacy and open access to validated emission factor databases to maximise impact and reliability.

Clinical relevance: AI-driven calculators such as ChatGPT can help dental teams without carbon accounting expertise to understand and reduce their environmental impacts, supporting the integration of sustainability into routine clinical practice.

简介与目的:本研究探讨了应用ChatGPT(一种生成式人工智能(AI)语言模型)开发适合牙科实践的用户友好型碳足迹计算器的可行性。基于先前开发的基于excel的工具,该研究旨在评估ChatGPT使用不同提示策略生成准确排放估算和可持续性建议的能力。方法:对三种提示变量进行检测。变体1采用非结构化请求来评估一般响应。变体2使用具有预定义发射因子的结构化数据输入。变体3将结构化输入与指令相结合,完全依赖先前经过验证的可持续性工具的输出。chatgpt生成的结果与Excel基准进行了比较,重点关注准确性、上下文相关性和与同行评议指导的一致性。结果:非结构化提示(变体1)产生有限上下文相关性的一般建议。结构化提示提高了准确性和特异性。变体2使用排放因子生成量身定制的产出,而变体3提供与已有文献一致的详细的、基于证据的建议。在各种变体中,ChatGPT的碳足迹估计值与Excel基准基本相当,只有与废物相关的排放量略有差异。结论:结构化提示显著提高了ChatGPT在生成可靠的碳足迹数据和牙科实践建议方面的性能。在透明排放因子和可信文献的支持下,生成式人工智能工具可以增加对环境数据的获取,支持可持续性决策,并促进临床环境中的气候行动。然而,局限性仍然存在,包括不准确输出(“幻觉”)和区域概括的风险。有效使用需要快速扫盲和开放获取经过验证的排放因子数据库,以最大限度地提高影响和可靠性。临床相关性:ChatGPT等人工智能驱动的计算器可以帮助没有碳会计专业知识的牙科团队了解和减少他们对环境的影响,支持将可持续性融入日常临床实践。
{"title":"Prompt-Driven ChatGPT Carbon Calculator for Dental Practices: Estimation and Tailored Improvement Strategies.","authors":"Brett Duane, Paul Ashley, James Larkin","doi":"10.1016/j.identj.2025.103979","DOIUrl":"10.1016/j.identj.2025.103979","url":null,"abstract":"<p><strong>Introduction and aims: </strong>This study investigates the feasibility of applying ChatGPT, a generative artificial intelligence (AI) language model, to develop a user-friendly carbon footprint calculator tailored for dental practices. Building on a previously developed Excel-based tool, the research aimed to evaluate ChatGPT's capacity to generate accurate emissions estimates and sustainability recommendations using different prompting strategies.</p><p><strong>Methods: </strong>Three prompting variants were tested. Variant 1 employed an unstructured request to assess general responses. Variant 2 used structured data entry with predefined emission factors. Variant 3 combined structured input with instructions to rely exclusively on outputs from a previously validated sustainability tool. ChatGPT-generated results were compared with the Excel benchmark, focusing on accuracy, contextual relevance and alignment with peer-reviewed guidance.</p><p><strong>Results: </strong>Unstructured prompts (Variant 1) produced general recommendations of limited contextual relevance. Structured prompts improved both accuracy and specificity. Variant 2 generated tailored outputs using emission factors, while Variant 3 provided detailed, evidence-based recommendations consistent with established literature. Across variants, ChatGPT's carbon footprint estimates were largely comparable to the Excel benchmark, with only minor discrepancies in waste-related emissions.</p><p><strong>Conclusion: </strong>Structured prompting significantly enhances ChatGPT's performance in generating reliable carbon footprint data and recommendations for dental practices. When supported by transparent emission factors and credible literature, generative AI tools can increase access to environmental data, support sustainability decision-making and facilitate climate action in clinical contexts. However, limitations remain, including risks of inaccurate outputs ('hallucinations') and regional generalisations. Effective use requires prompt literacy and open access to validated emission factor databases to maximise impact and reliability.</p><p><strong>Clinical relevance: </strong>AI-driven calculators such as ChatGPT can help dental teams without carbon accounting expertise to understand and reduce their environmental impacts, supporting the integration of sustainability into routine clinical practice.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 1","pages":"103979"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12809404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological Profile of Oral Health Conditions in Ecuador: A Retrospective Study From 2016 to 2022. 厄瓜多尔口腔健康状况流行病学概况:2016 - 2022年回顾性研究
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-12-31 DOI: 10.1016/j.identj.2025.109313
C M Cecilia Belén Molina Jaramillo, W B Willy Bustillos Torrez, C H Christian Patricio Hernández Carrera, A G Ana Patricia Gutiérrez, D L Darwin Vicente Luna-Chonata

Introduction: The Global Action Plan on Oral Health 2023-2030 is reaffirmed, promoting prevention, equitable access, and affordability of essential oral healthcare, aligned with universal health coverage and addressing social and commercial determinants of oral health. The plan aims for resilient health systems based on primary healthcare (PHC).

Objective: The objective of this study is to determine the frequency and distribution of the main oral pathologies treated in the establishments of the Ministry of Public Health of Ecuador between 2016 and 2022.

Methodology: This study employs a retrospective methodology, utilizing a database provided by the Ministry of Public Health of Ecuador of the RDACAA and PRAS applications, treated in the Qview program, and presented in Microsoft Excel 2019. The Ministry of Public Health of Ecuador uses the ICD-10 code for the coding of diagnoses, considering age, sex, ethnic self-identification, and priority groups.

Results: The results show that dentin caries (K02.1) is the most frequent pathology, followed by acute gingivitis (K05.0) and deposits on teeth (K03.6).

Conclusions: This study provides crucial information at a national level and proposes to be a pioneer in the planning and execution of oral health policies in Ecuador, suggesting a reformulation of the National Oral Health Plan.

引言:重申《2023-2030年全球口腔卫生行动计划》,促进基本口腔卫生保健的预防、公平获取和可负担性,与全民健康覆盖保持一致,并解决口腔健康的社会和商业决定因素。该计划旨在建立以初级卫生保健(PHC)为基础的弹性卫生系统。目的:本研究的目的是确定2016年至2022年厄瓜多尔公共卫生部机构治疗的主要口腔疾病的频率和分布。方法:本研究采用回顾性方法,利用厄瓜多尔公共卫生部提供的rdaaca和PRAS应用程序数据库,在Qview程序中进行处理,并在Microsoft Excel 2019中进行展示。厄瓜多尔公共卫生部使用ICD-10编码进行诊断编码,同时考虑到年龄、性别、种族自我认同和优先群体。结果:牙本质龋病(K02.1)是最常见的病理,其次是急性牙龈炎(K05.0)和牙体沉积(K03.6)。结论:本研究提供了国家层面的重要信息,并建议成为厄瓜多尔口腔健康政策规划和执行的先驱,建议重新制定国家口腔健康计划。
{"title":"Epidemiological Profile of Oral Health Conditions in Ecuador: A Retrospective Study From 2016 to 2022.","authors":"C M Cecilia Belén Molina Jaramillo, W B Willy Bustillos Torrez, C H Christian Patricio Hernández Carrera, A G Ana Patricia Gutiérrez, D L Darwin Vicente Luna-Chonata","doi":"10.1016/j.identj.2025.109313","DOIUrl":"10.1016/j.identj.2025.109313","url":null,"abstract":"<p><strong>Introduction: </strong>The Global Action Plan on Oral Health 2023-2030 is reaffirmed, promoting prevention, equitable access, and affordability of essential oral healthcare, aligned with universal health coverage and addressing social and commercial determinants of oral health. The plan aims for resilient health systems based on primary healthcare (PHC).</p><p><strong>Objective: </strong>The objective of this study is to determine the frequency and distribution of the main oral pathologies treated in the establishments of the Ministry of Public Health of Ecuador between 2016 and 2022.</p><p><strong>Methodology: </strong>This study employs a retrospective methodology, utilizing a database provided by the Ministry of Public Health of Ecuador of the RDACAA and PRAS applications, treated in the Qview program, and presented in Microsoft Excel 2019. The Ministry of Public Health of Ecuador uses the ICD-10 code for the coding of diagnoses, considering age, sex, ethnic self-identification, and priority groups.</p><p><strong>Results: </strong>The results show that dentin caries (K02.1) is the most frequent pathology, followed by acute gingivitis (K05.0) and deposits on teeth (K03.6).</p><p><strong>Conclusions: </strong>This study provides crucial information at a national level and proposes to be a pioneer in the planning and execution of oral health policies in Ecuador, suggesting a reformulation of the National Oral Health Plan.</p>","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 1","pages":"109313"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to 'Fibroblast Ferroptosis Aggravates Inflammation Response in Dental Pulpitis' [International Dental Journal Volume 75, Issue 6, December 2025, 103927]. “成纤维细胞上铁症加重牙髓炎的炎症反应”的更正[国际牙科杂志,第75卷,第6期,2025年12月,103927]。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-12-25 DOI: 10.1016/j.identj.2025.109325
Xiaohui Lv, Xuan Chen, Li Lin, Yang Li, Liecong Lin, Bingtao Wang, Xiaoshi Chen, Qianzhou Jiang
{"title":"Corrigendum to 'Fibroblast Ferroptosis Aggravates Inflammation Response in Dental Pulpitis' [International Dental Journal Volume 75, Issue 6, December 2025, 103927].","authors":"Xiaohui Lv, Xuan Chen, Li Lin, Yang Li, Liecong Lin, Bingtao Wang, Xiaoshi Chen, Qianzhou Jiang","doi":"10.1016/j.identj.2025.109325","DOIUrl":"10.1016/j.identj.2025.109325","url":null,"abstract":"","PeriodicalId":13785,"journal":{"name":"International dental journal","volume":"76 1","pages":"109325"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12828210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large Language Models and Machine Learning Framework for Predicting Dental Ceramics Performance. 预测牙科陶瓷性能的大型语言模型和机器学习框架。
IF 3.7 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-12-31 DOI: 10.1016/j.identj.2025.109358
Houqi Zhou, Yaxin Bai, Yuan Chen, Dongqi Fan, Peng Wang, Ping Ji, Tao Chen

Introduction and aims: Clinical fractures remain the primary cause of failure in dental all-ceramic restorations, highlighting the need to improve the mechanical performance and durability of ceramic material. This study aimed to develop a large language model (LLM)-based framework to automatically construct a structured database of dental ceramics and integrate it with machine learning (ML) to predict material properties and accelerate material design.

Methods: LLMs (Llama, Qwen, and DeepSeek) were employed to perform literature mining tasks, including text classification, information extraction from abstracts, and tabular data extraction. These processes were integrated into an automated pipeline to systematically extract and structure compositional and performance data from dental research articles. Ten ML algorithms were then trained using the curated database to establish predictive models of ceramic performance.

Results: In the classification task, a few-shot learning model with simple label prompts achieved an F1 score of 0.89. Fine-tuned LLMs achieved F1 scores exceeding 0.89 across various entity categories.ML models were developed to predict the classification of flexural strength, with the Extra Trees model performing best (F1 = 0.928), and external validation yielding F1 = 0.88. SHAP analysis identified ZrO₂ and SiO₂ as key contributor, and exhaustive search identified optimal compositional ranges.

Conclusions: This study demonstrates an AI-based pipeline combining LLM-driven data extraction and ML modelling, offering a scalable and accurate approach for accelerating the discovery and optimization of dental ceramics and other dental materials.

Clinical relevance: The findings underscore the potential of advanced LLMs and ML models in restorative dentistry and materials research.

简介和目的:临床骨折仍然是牙科全陶瓷修复失败的主要原因,强调了提高陶瓷材料的机械性能和耐久性的必要性。本研究旨在开发一个基于大型语言模型(LLM)的框架,自动构建牙科陶瓷的结构化数据库,并将其与机器学习(ML)相结合,预测材料性能,加速材料设计。方法:采用Llama、Qwen和DeepSeek等llm进行文献挖掘任务,包括文本分类、摘要信息提取和表格数据提取。这些过程被集成到一个自动化的管道中,系统地从牙科研究文章中提取和结构成分和性能数据。然后使用整理的数据库训练10个ML算法,以建立陶瓷性能的预测模型。结果:在分类任务中,带有简单标签提示的少镜头学习模型的F1得分为0.89。经过微调的llm在各个实体类别中获得了超过0.89的F1分数。利用ML模型预测抗弯强度分类,其中Extra Trees模型表现最佳(F1 = 0.928),外部验证结果F1 = 0.88。SHAP分析确定了ZrO₂和SiO₂是关键因素,穷举搜索确定了最佳成分范围。结论:本研究展示了一种基于人工智能的管道,将llm驱动的数据提取与ML建模相结合,为加速牙科陶瓷和其他牙科材料的发现和优化提供了一种可扩展和准确的方法。临床意义:研究结果强调了先进llm和ML模型在牙科修复和材料研究中的潜力。
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引用次数: 0
期刊
International dental journal
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