Pub Date : 2019-01-01DOI: 10.17706/ijbbb.2019.9.4.231-236
Lopez-Betancur Daniela, Olvera-Olvera Carlos, I. Hernandez, G. Carlos
{"title":"Effect of the RGB Wavelengths of LED Light on Growth Rates of Nile Tilapia Fry in Biofloc Technology (BFT) Systems","authors":"Lopez-Betancur Daniela, Olvera-Olvera Carlos, I. Hernandez, G. Carlos","doi":"10.17706/ijbbb.2019.9.4.231-236","DOIUrl":"https://doi.org/10.17706/ijbbb.2019.9.4.231-236","url":null,"abstract":"","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72916393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/IJBBB.2019.9.3.173-179
Handan Kulan, T. Dag
Down syndrome (DS) affects approximately one in 700 live births and it is considered as the most prevalent cause of intellectual disability (ID). DS is caused by the presence of an extra copy of the human chromosome21 (Hsa21) and has been investigated on protein levels by using the Ts65Dn mouse model. For the treatment of DS, many efforts have been made for developing drugs to rescue learning performance. In this paper, we apply forward feature selection method to identify the important proteins in which memantine and GABAA alpha5 receptor inverse agonistRO4938581 drugs affect. Identifying these gene products will help researchers to determine the molecular pathways which play key roles for rescuing performance in DS. Analyzing these pathways helps us to not only understand the learning process but also to contribute the new drug design for the treatment of DS.
{"title":"Analysis of Rescued Learning with Different Drugs in down Syndrome","authors":"Handan Kulan, T. Dag","doi":"10.17706/IJBBB.2019.9.3.173-179","DOIUrl":"https://doi.org/10.17706/IJBBB.2019.9.3.173-179","url":null,"abstract":"Down syndrome (DS) affects approximately one in 700 live births and it is considered as the most prevalent cause of intellectual disability (ID). DS is caused by the presence of an extra copy of the human chromosome21 (Hsa21) and has been investigated on protein levels by using the Ts65Dn mouse model. For the treatment of DS, many efforts have been made for developing drugs to rescue learning performance. In this paper, we apply forward feature selection method to identify the important proteins in which memantine and GABAA alpha5 receptor inverse agonistRO4938581 drugs affect. Identifying these gene products will help researchers to determine the molecular pathways which play key roles for rescuing performance in DS. Analyzing these pathways helps us to not only understand the learning process but also to contribute the new drug design for the treatment of DS.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75005734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/ijbbb.2019.9.3.158-165
Liwayway H. Acero
Insects are known as pests at home which can lower the quality of food for human. There are insects that destroy the quality of farm harvest, thereby decreasing its palatability and marketability. One of the very wellknown insects pests is the rice weevils (Sitophilus oryzae) which damages the quality of rice grain and lowers its market value. This study seeks to find out what concentration of Jackfruit Peel Ethanol Extract (JPEE) will give the highest mortality in 1.2 hours of observation. Experimental research method with four treatments, and twenty (rice weevils) samples/treatment, was used to gather pertinent data on this study. Jackfruit Peel was oven dried, grounded, macerated in 70% ethanol for 3 days and subjected to rotary evaporation. Different concentrations of Jackfruit Peel ethanol extract, (JPEE) was done. T(control), 0% JPEE, T1, 25% JPEE, T2, 50% JPEE and T3, 75% JPEE. Data on mortality for 1.2 hours with 20 minutes interval, was analyzed using Analysis of Variance and Fisher Least Significant Difference (LSD) Test as post hoc Test. Result revealed significant difference on the means of four treatments. It is imperative that rice weevils in T3 (750% of Jackfruit Peel Ethanol Extract) gave highest mortality in 1.2 hours, when exposed to JPEE. ANOVA revealed significant difference at 5% level of significance. Fisher LSD showed significant difference on control and treatments with JPEE. No significant differences exist among treatment with JPEE, which implies that any of the three treatment with JPEE can control rice weevils at 1.2 hours of observation. It shows that JPEE is a potential source of insecticide particularly for rice weevils.
{"title":"Insecticidal Property of Jackfruit (Artocarpus heterophyllus) Peel Ethanol Extract against Rice Weevils (Sitophilus oryzae)","authors":"Liwayway H. Acero","doi":"10.17706/ijbbb.2019.9.3.158-165","DOIUrl":"https://doi.org/10.17706/ijbbb.2019.9.3.158-165","url":null,"abstract":"Insects are known as pests at home which can lower the quality of food for human. There are insects that destroy the quality of farm harvest, thereby decreasing its palatability and marketability. One of the very wellknown insects pests is the rice weevils (Sitophilus oryzae) which damages the quality of rice grain and lowers its market value. This study seeks to find out what concentration of Jackfruit Peel Ethanol Extract (JPEE) will give the highest mortality in 1.2 hours of observation. Experimental research method with four treatments, and twenty (rice weevils) samples/treatment, was used to gather pertinent data on this study. Jackfruit Peel was oven dried, grounded, macerated in 70% ethanol for 3 days and subjected to rotary evaporation. Different concentrations of Jackfruit Peel ethanol extract, (JPEE) was done. T(control), 0% JPEE, T1, 25% JPEE, T2, 50% JPEE and T3, 75% JPEE. Data on mortality for 1.2 hours with 20 minutes interval, was analyzed using Analysis of Variance and Fisher Least Significant Difference (LSD) Test as post hoc Test. Result revealed significant difference on the means of four treatments. It is imperative that rice weevils in T3 (750% of Jackfruit Peel Ethanol Extract) gave highest mortality in 1.2 hours, when exposed to JPEE. ANOVA revealed significant difference at 5% level of significance. Fisher LSD showed significant difference on control and treatments with JPEE. No significant differences exist among treatment with JPEE, which implies that any of the three treatment with JPEE can control rice weevils at 1.2 hours of observation. It shows that JPEE is a potential source of insecticide particularly for rice weevils.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79270973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26646536.2019.v1.i1a.4
R. Alvin, Ambita Dave, Batalon Jamie Louise, Aba Berna Lou, Cortes Angelbert, Macabecha Cherray Gabrielle, M. Andrew
The objective of this study was to determine and compare the cell yield of Escherichia coli grown in minimal medium containing different concentrations of glucose (0.025%, 0.050% and 0.075%) and lactose (0.025%, 0.050% and 0.075%). Determination of the cell yield was done by oven drying the harvested cells to obtain the dry weight and analysis of the residual sugar in the liquid medium by phenol-sulfuric acid method. Highest initial concentration of glucose (596.667 ppm) and lactose (563.333 ppm) was recorded in minimal medium supplemented with 0.075% of the respective sugar. E. coli grown in 0.050% glucose (354.167 ppm) and 0.025% lactose (266.667 ppm) had the highest substrate consumed. Highest cell dry weight (μg/mL) and cell yield (μg/mL) was obtained in 0.075% glucose and 0.075% lactose. Comparing the two sugars, still, glucose had the highest cell yield (glucose 0.050% = 217.368 μg/mL and lactose 0.050% = 195.146 μg/mL; glucose 0.075% = 572.923 μg/ml and lactose 0.075% = 295.146 μg/ml). Highest Y was also recorded in highest sugar concentration (glucose 0.075% = 2.331; lactose 0.075% = 1.638). No statistical significance was observed when Y of different sugar concentrations were compared.
{"title":"Escherichia Coli cell yield in media containing different carbohydrates","authors":"R. Alvin, Ambita Dave, Batalon Jamie Louise, Aba Berna Lou, Cortes Angelbert, Macabecha Cherray Gabrielle, M. Andrew","doi":"10.33545/26646536.2019.v1.i1a.4","DOIUrl":"https://doi.org/10.33545/26646536.2019.v1.i1a.4","url":null,"abstract":"The objective of this study was to determine and compare the cell yield of Escherichia coli grown in minimal medium containing different concentrations of glucose (0.025%, 0.050% and 0.075%) and lactose (0.025%, 0.050% and 0.075%). Determination of the cell yield was done by oven drying the harvested cells to obtain the dry weight and analysis of the residual sugar in the liquid medium by phenol-sulfuric acid method. Highest initial concentration of glucose (596.667 ppm) and lactose (563.333 ppm) was recorded in minimal medium supplemented with 0.075% of the respective sugar. E. coli grown in 0.050% glucose (354.167 ppm) and 0.025% lactose (266.667 ppm) had the highest substrate consumed. Highest cell dry weight (μg/mL) and cell yield (μg/mL) was obtained in 0.075% glucose and 0.075% lactose. Comparing the two sugars, still, glucose had the highest cell yield (glucose 0.050% = 217.368 μg/mL and lactose 0.050% = 195.146 μg/mL; glucose 0.075% = 572.923 μg/ml and lactose 0.075% = 295.146 μg/ml). Highest Y was also recorded in highest sugar concentration (glucose 0.075% = 2.331; lactose 0.075% = 1.638). No statistical significance was observed when Y of different sugar concentrations were compared.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85529148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/ijbbb.2019.9.4.222-230
Gokhan Goy, Burak Kolukisa, Bakir-Gungor Burcu, I. Ugur, V. C. Gungor
Cardiovascular diseases (CVD), including coronary artery disease (CAD), myocardial infarction, and stroke are a group of highly prevalent and deadly diseases. The deaths from cardiovascular diseases were announced as 17.9 million in 2016 and it is expected that this number will reach approximately to 23.6 million by 2030. In order to facilitate the diagnosis and treatment of CVD, several computational approaches and data mining methods have been proposed until now. In this study, Apriori algorithm is utilized to find associations between features and rules based on UCI’s publicly available Cleveland dataset. Additionally, we generate different weighted association rules, which can help medical doctors to stratify patients and thus, propose different treatment approaches for each patient’s sub-category. Performance results show that the Apriori algorithm creates 58 rules when support and confidence parameters are set to 0.1 and 0.9, respectively. Utilizing weighted association rule approach, 6 important rules have been created based on Clinical Important Factors (CIF) and Framingham Heart Study Risk factors (FHS RF) on CVD.
心血管疾病(CVD)，包括冠状动脉疾病(CAD)、心肌梗死和中风是一组高发和致命的疾病。2016年，心血管疾病导致的死亡人数为1790万，预计到2030年，这一数字将达到约2360万。为了方便心血管疾病的诊断和治疗，目前已经提出了几种计算方法和数据挖掘方法。在本研究中，基于UCI公开的Cleveland数据集，利用Apriori算法寻找特征和规则之间的关联。此外，我们生成了不同的加权关联规则，这可以帮助医生对患者进行分层，从而为每个患者的子类别提出不同的治疗方法。性能结果表明，当支持度和置信度参数分别设置为0.1和0.9时，Apriori算法创建了58条规则。利用加权关联规则方法，基于临床重要因素(CIF)和Framingham Heart Study Risk Factors (FHS RF)对CVD的影响，建立了6条重要规则。
{"title":"Weighted Association Rules and Scoring Methodology for Cardiovascular Diseases","authors":"Gokhan Goy, Burak Kolukisa, Bakir-Gungor Burcu, I. Ugur, V. C. Gungor","doi":"10.17706/ijbbb.2019.9.4.222-230","DOIUrl":"https://doi.org/10.17706/ijbbb.2019.9.4.222-230","url":null,"abstract":"Cardiovascular diseases (CVD), including coronary artery disease (CAD), myocardial infarction, and stroke are a group of highly prevalent and deadly diseases. The deaths from cardiovascular diseases were announced as 17.9 million in 2016 and it is expected that this number will reach approximately to 23.6 million by 2030. In order to facilitate the diagnosis and treatment of CVD, several computational approaches and data mining methods have been proposed until now. In this study, Apriori algorithm is utilized to find associations between features and rules based on UCI’s publicly available Cleveland dataset. Additionally, we generate different weighted association rules, which can help medical doctors to stratify patients and thus, propose different treatment approaches for each patient’s sub-category. Performance results show that the Apriori algorithm creates 58 rules when support and confidence parameters are set to 0.1 and 0.9, respectively. Utilizing weighted association rule approach, 6 important rules have been created based on Clinical Important Factors (CIF) and Framingham Heart Study Risk factors (FHS RF) on CVD.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80686208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/ijbbb.2019.9.2.126-133
Y. Chuang, Ming-Chen Wang, Pei-Ru Chen
Cold atmosphere plasma has been developed and applied as a novel technology for cancer treatment. In most researches cap was directly applied to irradiate cancer cells or tissues. In this study, we report that CAP plasma discharge in cell culture medium and studied its effects on melanoma cancer cells. CAP plasma treated cell culture medium was applied to melanoma and fibroblast cells. Cell viability test by using MTT assay showed that treatment of with CAP plasma had the strongest effect on inducing apoptosis to inhibit melanoma cell proliferation and further cell metastasis. The most important is that CAP plasma treatment do not have any harmful effect on normal fibroblast cell, but do have exhibited strong cell killing effect on B16/F10 melanoma cell.
{"title":"Effects of a Nonthermal Atmospheric Pressure Plasma Discharged in Cell Culture Medium on Melanoma Cell","authors":"Y. Chuang, Ming-Chen Wang, Pei-Ru Chen","doi":"10.17706/ijbbb.2019.9.2.126-133","DOIUrl":"https://doi.org/10.17706/ijbbb.2019.9.2.126-133","url":null,"abstract":"Cold atmosphere plasma has been developed and applied as a novel technology for cancer treatment. In most researches cap was directly applied to irradiate cancer cells or tissues. In this study, we report that CAP plasma discharge in cell culture medium and studied its effects on melanoma cancer cells. CAP plasma treated cell culture medium was applied to melanoma and fibroblast cells. Cell viability test by using MTT assay showed that treatment of with CAP plasma had the strongest effect on inducing apoptosis to inhibit melanoma cell proliferation and further cell metastasis. The most important is that CAP plasma treatment do not have any harmful effect on normal fibroblast cell, but do have exhibited strong cell killing effect on B16/F10 melanoma cell.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90062891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/IJBBB.2019.9.1.27-34
M. R. S. Manseguiao, C. Demayo
Plants have differential expression of genes despite being propagated through cloning as in the case of mango. This study aimed to determine the effect of intraspecific variation in the host mangoes to the wing shape of the mango leafhopper, Idioscopus clypealis. Leafhopper populations were collected from four different orchards from individual trees. Wings were dissected, imaged and analyzed using multivariate analysis of variance, thin plate spline analysis and relative warp analysis. Results showed significant variation across all sampled trees in each geographic location regardless of farm management methods in the wing shape of the leafhopper. This variation is observed between genders and between trees in an orchard. Results also show that there is intraspecific variation in each host tree even in unsprayed populations and organic pesticide use. High adaptability to host defense and pesticides evidenced by wing variation may be key to persistence in this high value crop despite natural and synthetic control measures.
{"title":"Intraspecific Variation in the Wing Shape of the Mango Leafhopper, Idioscopus Clypealis, among Orchards in the Philippines","authors":"M. R. S. Manseguiao, C. Demayo","doi":"10.17706/IJBBB.2019.9.1.27-34","DOIUrl":"https://doi.org/10.17706/IJBBB.2019.9.1.27-34","url":null,"abstract":"Plants have differential expression of genes despite being propagated through cloning as in the case of mango. This study aimed to determine the effect of intraspecific variation in the host mangoes to the wing shape of the mango leafhopper, Idioscopus clypealis. Leafhopper populations were collected from four different orchards from individual trees. Wings were dissected, imaged and analyzed using multivariate analysis of variance, thin plate spline analysis and relative warp analysis. Results showed significant variation across all sampled trees in each geographic location regardless of farm management methods in the wing shape of the leafhopper. This variation is observed between genders and between trees in an orchard. Results also show that there is intraspecific variation in each host tree even in unsprayed populations and organic pesticide use. High adaptability to host defense and pesticides evidenced by wing variation may be key to persistence in this high value crop despite natural and synthetic control measures.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86049374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/ijbbb.2019.9.4.258-264
Anushka Ghosh, U. Hazra, D. Dutta
The potential nutraceutical benefits of carotenoids, which are versatile bioactive compounds, have been of great interest recently for its applications as dietary supplements. Carotenoids are red-orange coloured pigments which absorb light in the wavelength region of 400-550 nm. They are produced by plants, bacteria, algae and fungi and are abundantly distributed in the nature. In this study, our focus is on beta-cryptoxanthin (β-CRX), a yellow colored pro-vitamin A xanthophyll which is extracted from a previously isolated bacterium Kocuria marina DAGII grown in Brain Heart Infusion and sub-cultured in low cost dairy waste like whey and incubated at 25°C and 150 rpm for 5 days. The extracted beta-cryptoxanthin showed good radical scavenging activity and played a role in inhibition of lipid oxidation. Transferrin is a glycoprotein which plays a significant role in the mobilisation of iron in the body. It has two receptors TfR1 and TfR2 amongst which TfR1 binds to the iron-loaded transferrin. In cases of secondary hemochromatosis, HFE protein competes with transferrin to bind to TfR1 which leads to iron built up which is detrimental to the human body. Beta-cryptoxanthin was found to bind to Transferrin with a binding energy of -8.2 kcal/mol.
{"title":"Role of β-Cryptoxanthin as an Antioxidant and Its Ability to Bind with Transferrin","authors":"Anushka Ghosh, U. Hazra, D. Dutta","doi":"10.17706/ijbbb.2019.9.4.258-264","DOIUrl":"https://doi.org/10.17706/ijbbb.2019.9.4.258-264","url":null,"abstract":"The potential nutraceutical benefits of carotenoids, which are versatile bioactive compounds, have been of great interest recently for its applications as dietary supplements. Carotenoids are red-orange coloured pigments which absorb light in the wavelength region of 400-550 nm. They are produced by plants, bacteria, algae and fungi and are abundantly distributed in the nature. In this study, our focus is on beta-cryptoxanthin (β-CRX), a yellow colored pro-vitamin A xanthophyll which is extracted from a previously isolated bacterium Kocuria marina DAGII grown in Brain Heart Infusion and sub-cultured in low cost dairy waste like whey and incubated at 25°C and 150 rpm for 5 days. The extracted beta-cryptoxanthin showed good radical scavenging activity and played a role in inhibition of lipid oxidation. Transferrin is a glycoprotein which plays a significant role in the mobilisation of iron in the body. It has two receptors TfR1 and TfR2 amongst which TfR1 binds to the iron-loaded transferrin. In cases of secondary hemochromatosis, HFE protein competes with transferrin to bind to TfR1 which leads to iron built up which is detrimental to the human body. Beta-cryptoxanthin was found to bind to Transferrin with a binding energy of -8.2 kcal/mol.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81659072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/IJBBB.2019.9.1.35-41
Devanshi D. Dave, B. Jha
Alzheimer’s disease is the most common neurodegenerative disorder that is prevailing worldwide. Out of many reasons that may have their roles in prevailing this dementia, higher level of calcium concentration is one of them. There are various parameters that have their hands in maintaining the calcium level of the cytosol. Here we have taken into consideration the buffers and voltage gated calcium channel (VGCC) and used a two dimensional mathematical model to get the desired results. Finite element method (FEM) is employed to carry out the computations. Exogenous buffers like EGTA and BAPTA, which lower down the calcium concentration, have been used in addition to VGCC, which increases the calcium flux at the cytosolic level, to study the impact of calcium in Alzheimer’s disease. The obtained results show that there is increase in calcium concentration level of Alzheimer’s affected cell which render toxicity to the cell followed by cell death in AD.
{"title":"Study of Calcium Distribution in Alzheimer’s Disease Using Finite Element Technique","authors":"Devanshi D. Dave, B. Jha","doi":"10.17706/IJBBB.2019.9.1.35-41","DOIUrl":"https://doi.org/10.17706/IJBBB.2019.9.1.35-41","url":null,"abstract":"Alzheimer’s disease is the most common neurodegenerative disorder that is prevailing worldwide. Out of many reasons that may have their roles in prevailing this dementia, higher level of calcium concentration is one of them. There are various parameters that have their hands in maintaining the calcium level of the cytosol. Here we have taken into consideration the buffers and voltage gated calcium channel (VGCC) and used a two dimensional mathematical model to get the desired results. Finite element method (FEM) is employed to carry out the computations. Exogenous buffers like EGTA and BAPTA, which lower down the calcium concentration, have been used in addition to VGCC, which increases the calcium flux at the cytosolic level, to study the impact of calcium in Alzheimer’s disease. The obtained results show that there is increase in calcium concentration level of Alzheimer’s affected cell which render toxicity to the cell followed by cell death in AD.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82277387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.17706/IJBBB.2019.9.3.150-157
Yi-Chao Lee, Hwey-Lin Sheu, Shuiping Chang
The extracellular polymeric sustances (EPS) of algae have been studied as high-value natural resources for a number of application. Cladophora glomerata is the most abundant algae in freshwater throughout the world. This study discovered that under algal favoured pH environment, changing culture salinity can induce C. glomerata to secrete massive amount of EPS. Under pH 7.0 and pH 8.0, the total EPS increased from 3.10 mg g-1 fresh algae to 6.47 mg g-1 fresh algae, the protein to polysaccharide ratio (P/S) decreased from 0.31 to 0.21 with the increase in the salinity from 0 ‰ to 30.0‰. For pH 5.0, 6.0 and pH 9.0, 10.0 culture conditions, the total EPS between1.17 mg g-1 fresh algae to 4.32 mg g-1 fresh algae, the P/S ratio between 0.24 to 0.29 with the increase in the salinity from 0 ‰ to 30.0‰. Therefore, the total EPS and P/S ratio are influenced by culture salinity and pH obviously.
{"title":"The Effects for Extracellular Polymeric Sustances of Cladophora glomerata under Different Culture pH and Salinities","authors":"Yi-Chao Lee, Hwey-Lin Sheu, Shuiping Chang","doi":"10.17706/IJBBB.2019.9.3.150-157","DOIUrl":"https://doi.org/10.17706/IJBBB.2019.9.3.150-157","url":null,"abstract":"The extracellular polymeric sustances (EPS) of algae have been studied as high-value natural resources for a number of application. Cladophora glomerata is the most abundant algae in freshwater throughout the world. This study discovered that under algal favoured pH environment, changing culture salinity can induce C. glomerata to secrete massive amount of EPS. Under pH 7.0 and pH 8.0, the total EPS increased from 3.10 mg g-1 fresh algae to 6.47 mg g-1 fresh algae, the protein to polysaccharide ratio (P/S) decreased from 0.31 to 0.21 with the increase in the salinity from 0 ‰ to 30.0‰. For pH 5.0, 6.0 and pH 9.0, 10.0 culture conditions, the total EPS between1.17 mg g-1 fresh algae to 4.32 mg g-1 fresh algae, the P/S ratio between 0.24 to 0.29 with the increase in the salinity from 0 ‰ to 30.0‰. Therefore, the total EPS and P/S ratio are influenced by culture salinity and pH obviously.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83875005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：