Pub Date : 2023-10-01DOI: 10.22271/27069567.2023.v5.i4a.518
Mahrous Mohammed Elmetwaly, S. M. Aboelnasr, Ghada Abd Almomen Soliman, Ingy Abd Elwahab Ibrahim
{"title":"The relation between serum irisin levels with the anthropometric and metabolic parameters in obese and non-obese patients with type 2 diabetes mellitus","authors":"Mahrous Mohammed Elmetwaly, S. M. Aboelnasr, Ghada Abd Almomen Soliman, Ingy Abd Elwahab Ibrahim","doi":"10.22271/27069567.2023.v5.i4a.518","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i4a.518","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22271/27069567.2023.v5.i4a.520
Sathyapriyadharisini R, Gopalakrishnan Vr, Swadhin Ranjan Behera
{"title":"Haemovigilance in pregnancy: A prospective observational study in a secondary care hospital","authors":"Sathyapriyadharisini R, Gopalakrishnan Vr, Swadhin Ranjan Behera","doi":"10.22271/27069567.2023.v5.i4a.520","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i4a.520","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139329867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22271/27069567.2023.v5.i4a.516
Dr. Srinidhi Kondepudi
Cerebrotendinous Xanthomatosis is an uncommon autosomal recessive condition caused by a deficient enzyme in the bile acid synthesis pathway. This deficiency leads to the accumulation of cholestanol and cholesterol in various tissues, resulting in neurological, ocular, vascular, and musculoskeletal symptoms. I will be discussing the clinical, imaging, and genetic sequence characteristics of a 33-year-old female who exhibited symptoms such as gait instability, swelling on the posterior aspect of both ankles and medial malleolus, swaying while walking, speech disturbances, and coordination issues in both upper and lower limbs for the past six months. Imaging examinations were conducted, unveiling a range of observations consistent with Cerebrotendinous Xanthomatosis in both the brain and tendons. The diagnosis was subsequently verified through laboratory analyses and genetic sequencing.
{"title":"A brief report on a case of Cerebrotendinous Xanthomatosis","authors":"Dr. Srinidhi Kondepudi","doi":"10.22271/27069567.2023.v5.i4a.516","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i4a.516","url":null,"abstract":"Cerebrotendinous Xanthomatosis is an uncommon autosomal recessive condition caused by a deficient enzyme in the bile acid synthesis pathway. This deficiency leads to the accumulation of cholestanol and cholesterol in various tissues, resulting in neurological, ocular, vascular, and musculoskeletal symptoms. I will be discussing the clinical, imaging, and genetic sequence characteristics of a 33-year-old female who exhibited symptoms such as gait instability, swelling on the posterior aspect of both ankles and medial malleolus, swaying while walking, speech disturbances, and coordination issues in both upper and lower limbs for the past six months. Imaging examinations were conducted, unveiling a range of observations consistent with Cerebrotendinous Xanthomatosis in both the brain and tendons. The diagnosis was subsequently verified through laboratory analyses and genetic sequencing.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-01DOI: 10.22271/27069567.2023.v5.i4a.515
Dr. Ehab AbouAlazayem Abdelsalam Mohamed Shalaby
{"title":"Sedation treatment in critical care unit evolved over time","authors":"Dr. Ehab AbouAlazayem Abdelsalam Mohamed Shalaby","doi":"10.22271/27069567.2023.v5.i4a.515","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i4a.515","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139330741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-29DOI: 10.24321/2349.7181.202302
Mudit Chauhan
Introduction: Diabetes mellitus is a chronic metabolic disorder characterised by elevated blood glucose levels (hyperglycaemia) resulting from either insufficient insulin production or ineffective insulin utilisation by the body. Cardiac dysfunction refers to abnormalities in the structure or function of the heart, leading to impaired pumping ability and compromised circulation. The relationship between diabetes mellitus and cardiac dysfunction is complex and involves multiple factors, including metabolic, molecular, and cellular mechanisms. Aim: The aim of this study was to identify the predictors of cardiac dysfunction in patients with type 2 diabetes mellitus (T2DM). Material and Methods: The study employed an observational design and included a sample size of 284 participants with type 2 diabetes. It included T2DM patients (> 10 years of duration of the disease) who were more than 40 years of age. Result: The results showed a significant positive association between the age group of 61-80 years and abnormal/ elevated levels of B-type natriuretic peptide (BNP) [odds ratio (OR): 2.32; confidence interval (CI): 1.013 ± 3.301; p value: 0.039]. Furthermore, an increase in the duration of T2DM (21-30 years) was significantly associated with abnormal/ elevated BNP levels (> 100) [OR: 3.283; CI: 1.704 ± 3.827; p value: 0.003]. Conclusion: This study links BNP to ejection fraction (EF) in T2DM patients without heart failure symptoms. It also shows that elevated BNP is associated with reduced EF, and normal BNP is linked to preserved EF. It was seen that age, T2DM duration, and HbA1c impact BNP levels. Longer T2DM duration was found to be associated with lower EF. How to cite this article: Chaudhary AK, Singh RK, Singh A, Chauhan M. An Observational Study to Assess the Predictors of Cardiac Dysfunction in Type 2 Diabetes Patients. J Adv Res Med. 2023;10(1):1-8. DOI: https://doi.org/10.24321/2349.7181.202302
{"title":"An Observational Study to Assess the Predictors of Cardiac Dysfunction in Type 2 Diabetes Patients","authors":"Mudit Chauhan","doi":"10.24321/2349.7181.202302","DOIUrl":"https://doi.org/10.24321/2349.7181.202302","url":null,"abstract":"Introduction: Diabetes mellitus is a chronic metabolic disorder characterised by elevated blood glucose levels (hyperglycaemia) resulting from either insufficient insulin production or ineffective insulin utilisation by the body. Cardiac dysfunction refers to abnormalities in the structure or function of the heart, leading to impaired pumping ability and compromised circulation. The relationship between diabetes mellitus and cardiac dysfunction is complex and involves multiple factors, including metabolic, molecular, and cellular mechanisms. Aim: The aim of this study was to identify the predictors of cardiac dysfunction in patients with type 2 diabetes mellitus (T2DM). Material and Methods: The study employed an observational design and included a sample size of 284 participants with type 2 diabetes. It included T2DM patients (> 10 years of duration of the disease) who were more than 40 years of age. Result: The results showed a significant positive association between the age group of 61-80 years and abnormal/ elevated levels of B-type natriuretic peptide (BNP) [odds ratio (OR): 2.32; confidence interval (CI): 1.013 ± 3.301; p value: 0.039]. Furthermore, an increase in the duration of T2DM (21-30 years) was significantly associated with abnormal/ elevated BNP levels (> 100) [OR: 3.283; CI: 1.704 ± 3.827; p value: 0.003]. Conclusion: This study links BNP to ejection fraction (EF) in T2DM patients without heart failure symptoms. It also shows that elevated BNP is associated with reduced EF, and normal BNP is linked to preserved EF. It was seen that age, T2DM duration, and HbA1c impact BNP levels. Longer T2DM duration was found to be associated with lower EF. How to cite this article: Chaudhary AK, Singh RK, Singh A, Chauhan M. An Observational Study to Assess the Predictors of Cardiac Dysfunction in Type 2 Diabetes Patients. J Adv Res Med. 2023;10(1):1-8. DOI: https://doi.org/10.24321/2349.7181.202302","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136349496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.24321/2349.7181.202301
Mudit Chauhan
Introduction: Cardiovascular dysfunction, including heart failure (HF), is a significant contributor to maternal mortality and is a leading non- obstetric cause of death during pregnancy. The rates of cardiovascular disease (CVD) mortality have been increasing over the years, surpassing other pregnancy-related causes of death.Objectives: The study was conducted to assess the cardiac function in pregnant females during their third trimester and determine the prevalence of cardiac disease among pregnant women.Methods: The study was conducted among 260 pregnant women in their third trimester who were selected as per the predefined inclusion and exclusion criteria. A thorough physical examination was done and presenting complaints such as chest pain, breathlessness, palpitations, syncope, easy fatiguability, swelling of legs, orthopnoea, and paroxysmal nocturnal dyspnoea along with few biochemical markers were documented. Data collected during the study period, which spanned from July 1, 2021, to June 30, 2022, were subjected to appropriate statistical analysis.Results: The study had predominantly lower socioeconomic housewives (63.1% multigravida and 36.9% primigravida). Cardiac symptoms were present in 4.6% of the subjects. About 5.8% had chronic cardiac conditions, among whom, congenital heart issues were seen in 26.7%, while 73.3% had acquired heart disease. Atrial septal defect was the most common congenital condition, and rheumatic heart disease, particularly mitral stenosis and regurgitation, prevailed in acquired cases.Conclusion: The study demonstrated a 5.8% prevalence of cardiac disease in pregnant women during their third trimester, with acquired heart disease, particularly rheumatic heart disease, being more common than congenital heart disease.
{"title":"Assessment of Cardiac Function in Pregnant Females of a Tertiary Care Hospital of East Uttar Pradesh: A Cross-sectional Study","authors":"Mudit Chauhan","doi":"10.24321/2349.7181.202301","DOIUrl":"https://doi.org/10.24321/2349.7181.202301","url":null,"abstract":"Introduction: Cardiovascular dysfunction, including heart failure (HF), is a significant contributor to maternal mortality and is a leading non- obstetric cause of death during pregnancy. The rates of cardiovascular disease (CVD) mortality have been increasing over the years, surpassing other pregnancy-related causes of death.Objectives: The study was conducted to assess the cardiac function in pregnant females during their third trimester and determine the prevalence of cardiac disease among pregnant women.Methods: The study was conducted among 260 pregnant women in their third trimester who were selected as per the predefined inclusion and exclusion criteria. A thorough physical examination was done and presenting complaints such as chest pain, breathlessness, palpitations, syncope, easy fatiguability, swelling of legs, orthopnoea, and paroxysmal nocturnal dyspnoea along with few biochemical markers were documented. Data collected during the study period, which spanned from July 1, 2021, to June 30, 2022, were subjected to appropriate statistical analysis.Results: The study had predominantly lower socioeconomic housewives (63.1% multigravida and 36.9% primigravida). Cardiac symptoms were present in 4.6% of the subjects. About 5.8% had chronic cardiac conditions, among whom, congenital heart issues were seen in 26.7%, while 73.3% had acquired heart disease. Atrial septal defect was the most common congenital condition, and rheumatic heart disease, particularly mitral stenosis and regurgitation, prevailed in acquired cases.Conclusion: The study demonstrated a 5.8% prevalence of cardiac disease in pregnant women during their third trimester, with acquired heart disease, particularly rheumatic heart disease, being more common than congenital heart disease.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.22271/27069567.2023.v5.i3a.496
S. Khallaf, S. E. A. E. Ghany, A. Y. Ahmed, Ali Eid El Deeb, Mervat Abd El Satar El Sergany
{"title":"Role of saphenous nerve block in knee osteoarthritis","authors":"S. Khallaf, S. E. A. E. Ghany, A. Y. Ahmed, Ali Eid El Deeb, Mervat Abd El Satar El Sergany","doi":"10.22271/27069567.2023.v5.i3a.496","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3a.496","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85401251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.22271/27069567.2023.v5.i3a.500
Sumeet Juneja
{"title":"Kyasanur Forest Disease in India: Robust prevention and control strategy is the need of the hour","authors":"Sumeet Juneja","doi":"10.22271/27069567.2023.v5.i3a.500","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3a.500","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88554891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.22271/27069567.2023.v5.i3a.493
Rajeev Garg, Sunil Sathe
It is estimated that in India, one in four individuals have hypertension. However, only about 12% of these individuals achieve adequate blood pressure (BP) control. Uncontrolled BP is a major risk factor for cardiovascular diseases, including myocardial infarction and stroke. Along with an appropriate management plan, regular BP monitoring is the key. Traditional methods of monitoring BP in the clinical setting may not adequately reflect an individual’s BP outside of that setting, and higher BP in a non-clinical setting is linked to an increased risk of cardiovascular disease. Ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM) are both recognized methods for measuring BP outside of the clinic. ABPM and HBPM have been recognized by several guidelines and are an effective adjunct to office-based monitoring to measure white-coat and masked hypertension. This review includes the perspectives of Indian specialists and discusses the merits and limits of the ABPM and HBPM in an Indian context.
{"title":"Significance of ambulatory and home blood pressure monitoring in hypertension management: An Indian perspective","authors":"Rajeev Garg, Sunil Sathe","doi":"10.22271/27069567.2023.v5.i3a.493","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3a.493","url":null,"abstract":"It is estimated that in India, one in four individuals have hypertension. However, only about 12% of these individuals achieve adequate blood pressure (BP) control. Uncontrolled BP is a major risk factor for cardiovascular diseases, including myocardial infarction and stroke. Along with an appropriate management plan, regular BP monitoring is the key. Traditional methods of monitoring BP in the clinical setting may not adequately reflect an individual’s BP outside of that setting, and higher BP in a non-clinical setting is linked to an increased risk of cardiovascular disease. Ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM) are both recognized methods for measuring BP outside of the clinic. ABPM and HBPM have been recognized by several guidelines and are an effective adjunct to office-based monitoring to measure white-coat and masked hypertension. This review includes the perspectives of Indian specialists and discusses the merits and limits of the ABPM and HBPM in an Indian context.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135507406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.22271/27069567.2023.v5.i3a.491
Rana Mohamed ElSetiha, Ghada Mahmoud Ismaeal, M. Emam, Wael Mohamed El Mashad
Background: Chronic kidney disease is a significant global health issue with a sharply rising incidence, although modern medicine has made enormous strides, there are still several limitations to kidney disease prevention and therapy. The objective of this research was to investigate resveratrol's potential protective results against d-galactose-induced kidney injury in male albino rats. Methods: Forty adult male albino rats were used in this study (weighing 150 – 200 g). All rats were split into four equal groups, as follows: group I (Control group): injected with 0.9% saline subcutaneously every day for eight weeks, group II (D-gal group): received 120 mg/kg D‐gal in 0.9% saline subcutaneously every day for eight weeks, group III (Res group): received resveratrol at a dose of (50 mg/kg/day) dissolved in saline 0.9 % via oral gavage for eight weeks, group IV (D-gal + Res group): received D-gal subcutaneously and oral resveratrol daily for eight weeks in the same doses as in groups II and III. Results: group II (D-gal group) demonstrated significant rise in serum creatinine level, BUN, TNF-α level and renal MDA level with significant drop in renal GPx level while group IV (D-gal + Res) revealed significant decline in serum creatinine, BUN, TNF-α and renal MDA levels with significant increase in the renal GPx level. Conclusions: Resveratrol effectively protects the kidney tissues against d-galactose-induced injury in aging rats.
{"title":"Studying the protective role of resveratrol against D-galactose-induced renal damage in male albino rats","authors":"Rana Mohamed ElSetiha, Ghada Mahmoud Ismaeal, M. Emam, Wael Mohamed El Mashad","doi":"10.22271/27069567.2023.v5.i3a.491","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i3a.491","url":null,"abstract":"Background: Chronic kidney disease is a significant global health issue with a sharply rising incidence, although modern medicine has made enormous strides, there are still several limitations to kidney disease prevention and therapy. The objective of this research was to investigate resveratrol's potential protective results against d-galactose-induced kidney injury in male albino rats. Methods: Forty adult male albino rats were used in this study (weighing 150 – 200 g). All rats were split into four equal groups, as follows: group I (Control group): injected with 0.9% saline subcutaneously every day for eight weeks, group II (D-gal group): received 120 mg/kg D‐gal in 0.9% saline subcutaneously every day for eight weeks, group III (Res group): received resveratrol at a dose of (50 mg/kg/day) dissolved in saline 0.9 % via oral gavage for eight weeks, group IV (D-gal + Res group): received D-gal subcutaneously and oral resveratrol daily for eight weeks in the same doses as in groups II and III. Results: group II (D-gal group) demonstrated significant rise in serum creatinine level, BUN, TNF-α level and renal MDA level with significant drop in renal GPx level while group IV (D-gal + Res) revealed significant decline in serum creatinine, BUN, TNF-α and renal MDA levels with significant increase in the renal GPx level. Conclusions: Resveratrol effectively protects the kidney tissues against d-galactose-induced injury in aging rats.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82929640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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