Experiencing stress during pregnancy can increase about two times the probability of stillbirth in a pregnant woman. Given that the cause of stillbirth is not known but quitting smoking, having a balanced weight or maintaining a healthy weight, avoiding drugs, controlling blood pressure and diabetes can decrease its occurrence. Trauma, infection, genetics, lupus, coagulopathy, preeclampsia and alcohol consumption increase the chance of stillbirth. For most women, pregnancy is very stressful and it can even be said that it is the biggest stress in every woman's life and is associated with stillbirth. It is reported that approximately 1.18 times higher risk of stillbirth in mothers who had lost any first-degree relative the year before or during pregnancy. Due to the important role of stress in pregnancy, it is essential to have psychological interventions targeting women with previous miscarriages or stillbirths to improve maternal and neonatal outcomes.
{"title":"Stillbirth likelihood in pregnant women suffering from stress: A short review","authors":"Souzan Soufizadeh Balaneji, Mozhgan Vahabi Dastjerdi, Parmida Soleimani","doi":"10.22271/27069567.2023.v5.i2a.478","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2a.478","url":null,"abstract":"Experiencing stress during pregnancy can increase about two times the probability of stillbirth in a pregnant woman. Given that the cause of stillbirth is not known but quitting smoking, having a balanced weight or maintaining a healthy weight, avoiding drugs, controlling blood pressure and diabetes can decrease its occurrence. Trauma, infection, genetics, lupus, coagulopathy, preeclampsia and alcohol consumption increase the chance of stillbirth. For most women, pregnancy is very stressful and it can even be said that it is the biggest stress in every woman's life and is associated with stillbirth. It is reported that approximately 1.18 times higher risk of stillbirth in mothers who had lost any first-degree relative the year before or during pregnancy. Due to the important role of stress in pregnancy, it is essential to have psychological interventions targeting women with previous miscarriages or stillbirths to improve maternal and neonatal outcomes.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84700813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2a.473
Marwa Abd El-Rahman Zidan, Mohamed H Nasef, Moataz Sabry, M. Shaheen
Background: Herpetic stromal keratitis (HSK) is an immune-mediated disease due to primary infection with herpes simplex virus (HSV). It is now known about Cyclosporine A (CSA) that it selectively inhibits T-helper cell production of growth factors essential for B cell and cytotoxic T-cell differentiation and proliferation, so that the immune response which is considered the main cause of stromal lesion and opacity will be formed masking the transparent cornea affecting vision of the patients. The aim of our study was to compare between topical CSA ED versus Prednisolone ED in the treatment of HSK. Methods: The study is prospective, randomized, non-invasive and comparative on 30 eyes with HSK. Participants were divided randomly in numeric manner into 2 groups, each group included 15 eyes: Group (A): treated by topical CSA ED 0.4% and Group (B): treated by topical prednisolone acetate 1%. Comparison between both groups regarding effect on visual acuity, stromal haze, corneal edema, duration of healing, complications, HSV recurrence, vascularization and opacity was done. Results: There was no statistically significant difference between both groups in VA before treatment however, it was statistically significant lower in group B after treatment. There was no statistically significant difference between both groups in grade of stromal infiltration before treatment but there was a statistically significant difference after treatment. Duration of healing was statistically significant lower in group B compared to group A Conclusions: According to our study, CSA ED (0.4%) is effective and comparable to corticosteroid in management of HSK. It may be less tolerable and take longer duration of action but it is superior to steroids as regard the effect on corneal opacity. It has the advantage to decrease corneal vascularization as well. Using corticosteroids is associated with complications especially in more complicated cases like thin cornea and epithelial defects. It causes disease recurrence and IOP elevation so CSA ED is recommended to be used in these cases.
背景:疱疹性间质角膜炎(HSK)是一种由单纯疱疹病毒(HSV)原发感染引起的免疫介导性疾病。目前已知环孢素A (Cyclosporine A, CSA)选择性地抑制t辅助细胞产生B细胞和细胞毒性t细胞分化和增殖所必需的生长因子，从而形成被认为是间质病变和混浊的主要原因的免疫反应，掩盖透明角膜，影响患者视力。本研究的目的是比较局部CSA ED与强的松龙ED治疗HSK的疗效。方法:采用前瞻性、随机、非侵入性、对照的方法对30只HSK患者进行研究。将受试者按数值随机分为2组，每组15只眼:A组:外用CSA ED 0.4%， B组:外用醋酸泼尼松龙1%。比较两组患者的视力、间质混浊、角膜水肿、愈合时间、并发症、HSV复发、血管化和混浊的影响。结果:两组治疗前VA差异无统计学意义，治疗后B组VA明显降低，差异有统计学意义。治疗前两组间质浸润程度差异无统计学意义，治疗后两组间质浸润程度差异有统计学意义。结论:根据我们的研究，CSA ED(0.4%)在HSK治疗中是有效的，与皮质类固醇相当。它的耐受性可能较差，作用时间也较长，但在对角膜混浊的影响方面，它优于类固醇。它还具有减少角膜血管化的优点。使用皮质类固醇与并发症有关，特别是在更复杂的情况下，如角膜薄和上皮缺陷。它会导致疾病复发和IOP升高，因此建议在这些病例中使用CSA ED。
{"title":"Topical cyclosporine: A versus prednisolone in the treatment of herpetic stromal keratitis","authors":"Marwa Abd El-Rahman Zidan, Mohamed H Nasef, Moataz Sabry, M. Shaheen","doi":"10.22271/27069567.2023.v5.i2a.473","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2a.473","url":null,"abstract":"Background: Herpetic stromal keratitis (HSK) is an immune-mediated disease due to primary infection with herpes simplex virus (HSV). It is now known about Cyclosporine A (CSA) that it selectively inhibits T-helper cell production of growth factors essential for B cell and cytotoxic T-cell differentiation and proliferation, so that the immune response which is considered the main cause of stromal lesion and opacity will be formed masking the transparent cornea affecting vision of the patients. The aim of our study was to compare between topical CSA ED versus Prednisolone ED in the treatment of HSK. Methods: The study is prospective, randomized, non-invasive and comparative on 30 eyes with HSK. Participants were divided randomly in numeric manner into 2 groups, each group included 15 eyes: Group (A): treated by topical CSA ED 0.4% and Group (B): treated by topical prednisolone acetate 1%. Comparison between both groups regarding effect on visual acuity, stromal haze, corneal edema, duration of healing, complications, HSV recurrence, vascularization and opacity was done. Results: There was no statistically significant difference between both groups in VA before treatment however, it was statistically significant lower in group B after treatment. There was no statistically significant difference between both groups in grade of stromal infiltration before treatment but there was a statistically significant difference after treatment. Duration of healing was statistically significant lower in group B compared to group A Conclusions: According to our study, CSA ED (0.4%) is effective and comparable to corticosteroid in management of HSK. It may be less tolerable and take longer duration of action but it is superior to steroids as regard the effect on corneal opacity. It has the advantage to decrease corneal vascularization as well. Using corticosteroids is associated with complications especially in more complicated cases like thin cornea and epithelial defects. It causes disease recurrence and IOP elevation so CSA ED is recommended to be used in these cases.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75714159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2a.472
Mai Elsayed Ibrahim, A. Shahba, W. Mohamed, S. Hazzaa
{"title":"Interleukin -21 gene RS 2221903 polymorphisms in rheumatoid arthritis patients","authors":"Mai Elsayed Ibrahim, A. Shahba, W. Mohamed, S. Hazzaa","doi":"10.22271/27069567.2023.v5.i2a.472","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2a.472","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75958049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2b.489
Eman R El Fiky, A. Shahba, Hesham Ahmed El Serogy, M. Sweilam
Background: A severe form of heterogeneous autoimmune illness called systemic lupus erythematosus (SLE) is characterised by the generation of autoantibodies against specific self-antigens. The aim of the present study is to evaluate LRRK2 and beclin-1 as autophagic markers in patients of SLE and their role in the pathogenesis. Methods: This case-control study was performed on 60 subjects, aged between 15-45 years old. Study participants were divided into two categories: Group I: comprised 30 patients with newly diagnosed SLE. Group II: included 30 apparently healthy age and sex matched subjects. Results: SLEDIA was positively associated with beclin1, LRRK2, ANA, Anti ds DNA. Beclin1 was positively associated with LRRK2, ANA, Anti ds DNA. LRRK2 was positively associated with ANA, Anti ds DNA. Detection of beclin1 relative gene expression with 84% positive predictive value (PPV), 90% sensitivity, 83% specificity. Detection of LRRK2 its relative gene expression with 81% negative predictive value (NPV), 76% PPV, 83% sensitivity, 73% specificity. Conclusions: These autophagic markers (LRRK2 and beclin1) correlate positively with the disease activity and severity and may have a role in disease pathogenesis and progression.
{"title":"Study of LRRK2 and Beclin-1: Gene expression as autophagic markers in systemic lupus Erythromatosus in Egyptian populations","authors":"Eman R El Fiky, A. Shahba, Hesham Ahmed El Serogy, M. Sweilam","doi":"10.22271/27069567.2023.v5.i2b.489","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2b.489","url":null,"abstract":"Background: A severe form of heterogeneous autoimmune illness called systemic lupus erythematosus (SLE) is characterised by the generation of autoantibodies against specific self-antigens. The aim of the present study is to evaluate LRRK2 and beclin-1 as autophagic markers in patients of SLE and their role in the pathogenesis. Methods: This case-control study was performed on 60 subjects, aged between 15-45 years old. Study participants were divided into two categories: Group I: comprised 30 patients with newly diagnosed SLE. Group II: included 30 apparently healthy age and sex matched subjects. Results: SLEDIA was positively associated with beclin1, LRRK2, ANA, Anti ds DNA. Beclin1 was positively associated with LRRK2, ANA, Anti ds DNA. LRRK2 was positively associated with ANA, Anti ds DNA. Detection of beclin1 relative gene expression with 84% positive predictive value (PPV), 90% sensitivity, 83% specificity. Detection of LRRK2 its relative gene expression with 81% negative predictive value (NPV), 76% PPV, 83% sensitivity, 73% specificity. Conclusions: These autophagic markers (LRRK2 and beclin1) correlate positively with the disease activity and severity and may have a role in disease pathogenesis and progression.","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80698041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2b.483
Ammar Abd El Majeed Abd Ali, Baseem Ali Hussein, Hawraa Kamel Shaalan
{"title":"Lymphocyte count as a predictor of severity of COVID-19 infection","authors":"Ammar Abd El Majeed Abd Ali, Baseem Ali Hussein, Hawraa Kamel Shaalan","doi":"10.22271/27069567.2023.v5.i2b.483","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2b.483","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84889353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2a.470
Dr. Vivek D Patil, Dr. Baba S Yelke, Dr. Rohit Salame, Dr. Tejas Madavi
{"title":"A study of complications encountered in chronic kidney disease patient undergoing hemodialysis at tertiary health center: A cross sectional study","authors":"Dr. Vivek D Patil, Dr. Baba S Yelke, Dr. Rohit Salame, Dr. Tejas Madavi","doi":"10.22271/27069567.2023.v5.i2a.470","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2a.470","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86338132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.22271/27069567.2023.v5.i2b.487
Mayada Gamal Baraka, E. H. EL‐SHIEKH, M. Khalfallah, M. Safa
{"title":"Monocyte to lymphocyte ratio as a predictor of left ventricular hypertrophy in end stage renal disease patients underlying hemodialysis","authors":"Mayada Gamal Baraka, E. H. EL‐SHIEKH, M. Khalfallah, M. Safa","doi":"10.22271/27069567.2023.v5.i2b.487","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i2b.487","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90889844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/27069567.2023.v5.i1b.452
Mai Mohamed Hegazy, F. Ghaith, A. Taha, Sara Mohamed Hmam
{"title":"Serum level of interleukin: 8 in correlation with aplastic anemia severity","authors":"Mai Mohamed Hegazy, F. Ghaith, A. Taha, Sara Mohamed Hmam","doi":"10.22271/27069567.2023.v5.i1b.452","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i1b.452","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74845301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/27069567.2023.v5.i1a.437
Sanapala Praveen, C. V. Saradhi, Darbha Prabhath Suraj
{"title":"A study of atypical presentations and rare complications of malaria","authors":"Sanapala Praveen, C. V. Saradhi, Darbha Prabhath Suraj","doi":"10.22271/27069567.2023.v5.i1a.437","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i1a.437","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73352825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.22271/27069567.2023.v5.i1a.425
M. Elkady, Hamed Abdelwahab Shahen, Mahmoud Fouad Abdelaziz, Ahmed S. Elguindy, M. Ammar
{"title":"Efficiency of virtual surgical planning in management of maxillofacial trauma","authors":"M. Elkady, Hamed Abdelwahab Shahen, Mahmoud Fouad Abdelaziz, Ahmed S. Elguindy, M. Ammar","doi":"10.22271/27069567.2023.v5.i1a.425","DOIUrl":"https://doi.org/10.22271/27069567.2023.v5.i1a.425","url":null,"abstract":"","PeriodicalId":13835,"journal":{"name":"International Journal of Advanced Research in Medicine","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81593421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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